860results about "Anion exchanger materials" patented technology

Described herein are methods of recovering lithium from dilute lithium sources. The methods include extracting lithium from an extraction feed using direct lithium extraction in an extraction stage to yield a lithium intermediate, performing one or more concentration operations, each concentration operation concentrating an input stream to yield an output feed, wherein the input stream is obtained from the lithium intermediate and / or the extraction feed is obtained from the output feed. At least one of the concentration operations includes a membrane separation operation having a plurality of reactors in series each having a semi-permeable membrane, such as a counter-flow reverse osmosis operation. Methods may also include generating a low TDS stream as a permeate from any of the one or more concentration operations, wherein the low TDS stream is recycled or used as fresh water.

The invention relates to a strong cation exchange chromatographic filler as well as a preparation method and application thereof. The strong cation exchange chromatographic filler comprises sulfonated poly (glycidyl methacrylate)-divinyl benzene microspheres. The strong cation exchange chromatographic filler provided by the invention can simultaneously show excellent separation selectivity on rare earth elements, and also has long-term stability and excellent cycle performance, so that the economic cost is reduced, and the strong cation exchange chromatographic filler has relatively high economic benefits and is green and environment-friendly.

A method is provided, comprising: obtaining, for a chromatography machine including a first dispersed plug flow reactor (DPFR) and a continuous stirred tank reactor (CSTR) prior to a column, and a second DPFR after the column, geometric measurements associated with the second DPFR; generating, by a processor, transport model parameters for a transport model associated with the second DPFR based on the geometric measurements; feeding a tracer molecule into the chromatography machine; capturing one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine; and estimating, by the processor, based on the transport model associated with the second DPFR and the one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine, one or more transport model parameters for a transport model associated with the first DPFR and the CSTR.

The present invention relates to the process to prepare recombinant lectin having amino acid sequence of SEQ ID NO:1, wherein the process comprises fed-batch fermentation of a clone in a host cell at specific feeding rate with carbon to Nitrogen ratio of 3:1 to 6:1. The invention also relates to the process of purification of recombinant lectin having amino acid sequence of SEQ ID NO: 1.

The invention relates to the technical field of pharmaceutical separation, and discloses a device, method and application of ursodeoxycholic acid preparation and purification. The device comprises a separation tank, wherein a batching center cylinder is rotatably installed inside the separation tank, and a plurality of elution tubes are arranged around the batching center cylinder. The batching center cylinder rotates forward, and centrifugal force is used to load adsorption resin into each elution tube. Then, the batching center cylinder rotates reversely, and the volume of each elution tube is poured out by anti-centrifugal force, so as to achieve a more convenient effect of replacing the adsorption resin. The replaced adsorption resin is cleaned outside the device and reused. The purification method and application thereof realize column loading, sample loading and elution in the separation tank in sequence without stopping the machine for operation, and simplify the column loading and column replacement operations, so as to solve the problem that the separation and purification process in the prior art is complicated and not suitable for batch production, so as to meet the industrial production requirements of solvent recycling.

The present invention relates to a system for capturing carbon dioxide from an air stream. The system includes a carbon dioxide capturing unit that includes a humidity / temperature adjusting unit with an evaporative cooling unit and a CO2 adsorbing unit. The CO2 adsorbing unit includes a sorbent column made of polyamine-Cu (II) complex resin. The humidity / temperature adjusting unit receives air stream from ambient atmosphere and process the air stream to obtain a humidity-adjusted air stream. The CO2 adsorbing unit receives the humidity-adjusted air stream to pass through the sorbent column. The sorbent column selectively adsorbs the CO2 from the humidity-adjusted air stream. The sorbent column is regenerated using an alkaline stream to separate the adsorbed CO2 from the sorbent column.

The invention belongs to the technical field of radioactive isotope separation and purification, and particularly relates to a device for separating and purifying carrier-free lutetium 177. Comprising a mounting rack, a salt transfer assembly arranged in the middle of the front side of the mounting rack, a valve assembly arranged in the middle of the rear side of the mounting rack, a separation and purification column arranged on one side of the salt transfer assembly, a sample injection system arranged on one side of the valve assembly, a fraction assembly arranged above the mounting rack and a waste liquid assembly arranged on one side of the mounting rack, the control terminal is used for controlling the sampling system and the on-off of valves in the valve assembly so as to control the flowing of liquid in the separation and purification device, so that the functions of ytterbium and lutetium separation, lutetium-to-salt concentration and ytterbium-to-salt recovery in the separation and purification device are realized. The problems that in the prior art, an overall device for separating and purifying carrier-free lutetium-177 is large in size and occupied area, the requirement for the automation control degree is high, and the service life of parts is short are solved.

Disclosed herein are methods and systems for the use of extraction chromatography resins to concentrate Ac from dilute solutions that may contain Th isotopes and / or other isotopes, such as Ra. As disclosed herein, at least some extraction chromatography resins strongly retain trivalent actinides between 4 and 6 M HNO3 that can be recovered in good yields with small volumes of dilute acids. These small volumes of acid eluents result in significant concentration of the solution of the trivalent / certain tetravalent ions, such that they can be further processed without requiring lengthy evaporation steps that are utilized in standard Ac concentration methods.

The invention discloses a method for extracting a target product from a milk raw material, and relates to the technical field of food processing. According to the method, before strong anion exchange chromatography is carried out, a synergistic pretreatment step of ultrafiltration and conductivity adjustment is introduced, so that acceleration, synergism, quality improvement and cost reduction of the chromatography process are realized, and the technical bottlenecks of low speed, easiness in pollution, instability and the like of the traditional ion exchange chromatography during treatment of milk raw materials are overcome; and a solution is provided for high-efficiency, high-purity and large-scale production of the beta-lactoglobulin and the alpha-lactalbumin. According to the method, strong anion exchange chromatography and weak anion exchange chromatography can be combined, so that the extraction purity of beta-lactoglobulin and alpha-lactalbumin can be further improved; in addition, the method can synchronously realize high-efficiency extraction of various target substances such as casein micelles, lactose and milk mineral salts, so that the additional value and resource utilization efficiency of milk source byproducts are greatly improved.

The invention discloses a parameter differential separation process, and relates to the technical field of separation. The defects in the prior art are overcome. The method specifically comprises the following steps: carrying out a generalized separation process by using a parameter differential moving bed, and operating the generalized separation process to eliminate a displacement zone in chromatographic sequential operation; the method comprises the following steps: contacting a mobile-phase liquid feeding solution with solid-phase resin / adsorbent filler through a novel mass transfer equilibrium contact method, and starting to obtain a characteristic separation curve; the multiple components contained in the mobile phase liquid feed solution are separated by a new mass transfer equilibrium contact process such that at least one component contained in the mobile phase liquid feed solution can be adsorbed onto the resin / adsorbent. The method realizes final separation of a large-scale production separation system, improves the maximum mass transfer efficiency, can also be used for a binary separation system in the separation process of glucose and fructose, reduces the consumption of washing liquid, and reduces the final power consumption.

The present invention provides a kit and a detection method for synchronously detecting catecholamines and their metabolites, which relates to the technical field of analytical detection. The kit contains a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device, and a solid-phase extraction packing material. Among them, the solid-phase extraction packing material creatively adopts zwitterionic exchange microspheres containing both carboxyl and quaternary ammonium groups. The kit can not only synchronously and efficiently separate and detect 8 kinds of catecholamines and their metabolites in urine samples, but also separate and detect 6 kinds of amino-containing catecholamines and their metabolites in blood samples. When the above kit is used to separate and detect catecholamines and their metabolites, the extraction recovery rate is relatively high, and the linear range covers the reference value range of normal detection, which can significantly shorten the detection time of urine samples, improve the detection efficiency of mass spectrometry, and is conducive to popularization and application in clinical detection.

The present disclosure provides various characteristics for treating tail brine extracted from a bromine plant, when said brine contains residual bromine and chlorine with low pH and high ORP values that will be used in a lithium extraction production facility. The method conditions the extracted tail brine by adding either sodium hydroxide or ammonium hydroxide to bring its pH levels to between 5.5 and 6.5. The conditioned tail brine then gets pre-treated with hydrazine in either less than 70 ppm if used in combination with sodium hydroxide; or 195 ppm if used with ammonium hydroxide until the ORP levels have reached to below 100 mV. The extracted tail brine is then processed through DLE processing device having four groups of adsorption columns filled with lithium adsorption resins that, after treating the extracted tail brine, discharges the raw eluate solution to an effluent tail brine tank using an effluent tail brine pump connected to the DLE processing device.

A full solid-waste micro-expansive concrete and its preparation method are provided, and relate to the field of concrete material technologies. The full solid-waste micro-expansive concrete includes the following components in parts by weight: 920-1060 parts of a coarse aggregate, 460-582 parts of a fine aggregate, 11-19 parts of an expansive agent, 389-512 parts of a modified solid-waste-based cementitious material, and 231-268 parts of water. The coarse aggregate is coal gangue. The fine aggregate is waste ceramic. The modified solid-waste-based cementitious material includes a solid-waste-based clinker, modified polyvinyl alcohol, and a modified anion exchange resin. The solid-waste-based clinker is prepared from the coal gangue, carbide slag, and desulfurization gypsum. The expansive agent is obtained by calcining the carbide slag. The concrete prepared can ensure the initial strength of the concrete, and guarantee continuous micro-expansion in the later stage, compensating for shrinkage and thereby increasing the overall strength of the concrete.

This invention discloses a method for preparing a high-temperature resistant, strongly basic anion exchange resin, belonging to the field of ion exchange resins. The method includes three steps: First, white spheres with a crosslinking degree of 6-10 undergo a chloromethylation reaction by sequentially adding zinc dichloride and tin tetrachloride to improve the uniformity of the chloromethyl group distribution in the chlorospheres; second, the chlorospheres undergo an etherification reaction using tetrabutylammonium bromide as a phase transfer catalyst, and the dropping rate of sodium methoxide solution is controlled to improve the etherification conversion rate; finally, the etherification product undergoes a quaternization reaction with a trimethylamine aqueous solution to obtain the strongly basic anion exchange resin. This invention, by selecting the degree of crosslinking and optimizing the catalyst addition method for chloromethylation and the sodium methoxide dropping rate for the etherification reaction, results in a more uniform distribution of quaternary ammonium groups in the resin, significantly improving the ion exchange capacity and high-temperature resistance of the resin.

The preparation method comprises the following steps: by taking a seed ball matrix as a base ball, preparing monodisperse porous polymer microspheres through one-step swelling polymerization, then converting residual double bonds on the surfaces of the polymer microspheres into epoxy groups by adopting an oxidation reaction, then grafting a dextran hydrophilic layer to completely cover hydrophobic sites on the surfaces, and then carrying out chemical modification and ligand bonding by utilizing hydroxyl on dextran, so as to obtain the polymer microspheres. The prepared ion exchange polymer filler is porous, high in hydrophilicity and high in exchange capacity and is successfully applied to protein separation and purification. Therefore, the ion exchange purification filler prepared by the method has a good application prospect.

The present invention discloses an acid-sugar separation resin and a preparation method thereof, belonging to separation resin technology. The resin is formed by modifying sodium styrene sulfonate and a chloride ion type strong alkaline anion exchange resin, and then heating and polymerizing with an azo compound water-soluble free radical initiator. The acid-sugar separation resin provided by the present invention is an amphoteric ion exchange resin, and the functional groups contained in the resin structure: quaternary ammonium salt groups, so that the resin obtains excellent acid-sugar separation effect and improves the acid-sugar separation rate; the sulfonate groups contained can avoid the sulfuric acid tailing phenomenon, avoid the sulfuric acid tailing phenomenon to reduce the concentration of recovered sulfuric acid, thereby increasing the cost of subsequent sulfuric acid concentration.

Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

The invention provides a production process of SEMI-G5-grade high-purity NMP (N-Methyl Pyrrolidone), which is characterized in that metal ions, magnetic foreign / non-magnetic foreign particulate matters and the like of conventional industrial-grade NMP are completely removed by adopting a multi-section rectification, resin adsorption and precise filtration process, so that the SEMI-G5-grade NMP reaches the SEMI-G5 grade in an ultra-clean high-purity reagent; and the use requirements on the ultra-clean high-purity NMP in the fields of semiconductors, integrated circuits and novel display are met.

The invention discloses a strongly acidic cation exchange chromatography material and a preparation method thereof. The chromatography material takes microspheres as a matrix material, and takes halogenated alkyl sodium benzenesulfonate and hydroxyl-containing halogenated alkyl sodium sulfonate as functional groups. The preparation method comprises the following steps: epoxy activation: dispersing microspheres in a continuous phase, adding a reducing agent, an alkaline solution and a grafting reagent, and reacting to obtain epoxy activated microspheres; preliminary sulfonation: enabling the epoxy activated microspheres to react with hydroxyl-containing halogenated alkyl sodium sulfonate serving as a first sulfonating agent under an alkaline condition to obtain preliminarily sulfonated microspheres; deep sulfonation: enabling the preliminarily sulfonated microspheres to react with halogenated sodium alkyl benzene sulfonate serving as a second sulfonating agent to obtain a target product. The strongly acidic cation exchange chromatography material provided by the invention can achieve the effects of high protein adsorption capacity and high ion exchange site density.

The invention provides a kit for synchronously detecting catecholamine and metabolites thereof and a detection method, and relates to the technical field of analysis and detection. The kit comprises a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device and a solid-phase extraction filler. Wherein the solid-phase extraction filler creatively adopts an amphiphilic ion exchange microsphere containing two functional groups, namely carboxyl and quaternary ammonium at the same time. The kit can be used for synchronously and efficiently separating and detecting eight catecholamines and metabolites thereof in a urine sample; and 6 kinds of catecholamines containing amino groups and metabolites thereof in a blood sample can be separated and detected. When the kit is used for separating and detecting catecholamine and metabolites thereof, the extraction and recovery rate is high, the linear range covers the reference value range of normal detection, the detection time of a urine sample can be remarkably shortened, the detection efficiency of mass spectrum is improved, and popularization and application in clinical detection are facilitated.

The invention provides a continuous fluid separation system for recovering lithium from mirabilite, and relates to the technical field of continuous fluid separation. A continuous fluid separation system for recovering lithium from mirabilite comprises a plurality of treatment subsystems, each treatment subsystem comprises an exchange area, a material washing area and an acid regeneration analysis area which are arranged in sequence, and each separation unit of the treatment subsystems is filled with a titanium adsorbent filler; the exchange area adopts a three-parallel two-serial feeding mode; gradient washing is carried out in a three-string mode in the material washing area; and the acid regeneration analysis area adopts a three-parallel analysis mode. According to the continuous fluid separation system for recovering lithium from mirabilite, the recovery rate of lithium can exceed 90%, continuous operation is achieved, product components and concentration are kept stable, and the use amount of washing water and an acid regenerant is greatly reduced.

This method comprising the steps of reacting waste polyester with a chromophore decomposing agent after depolymerization and separating and removing bis(2-hydroxyethyl)terephthalate can provide regenerated bis(2-hydroxyethyl)terephthalate having a low yellow index from highly contaminated waste polyester.

The present invention relates to the technical field of resin cleaning, and specifically provides a method for cleaning a cationic resin and an application thereof. The present invention provides a method for cleaning a cationic resin, wherein a cleaning solution A and a cleaning solution B are used to clean the cationic resin; the cleaning solution A is an aqueous solution of a chelating agent; the chelating agent includes EDTA or its sodium salt and GLDA; the molar ratio of EDTA or its sodium salt to GLDA is (0.1-2):1; the cleaning solution B is a bacterial solution, and the bacteria in the bacterial solution include Leuconostoc and Pediococcus; the ratio of the number of live bacteria of Leuconostoc and Pediococcus is 1:(0.4-3.6). The method for cleaning a cationic resin provided by the present invention can effectively remove the heavy metals adsorbed by the resin without affecting its adsorption capacity.

The invention relates to benzenesulfonic functionalized silica gel as well as a preparation method and application thereof, and the preparation method comprises the step of reacting silica gel with 2-(4-chlorosulfonylphenyl) ethyl trichlorosilane in a solvent to obtain the benzenesulfonic functionalized silica gel. The benzenesulfonic acid group functionalized silica gel provided by the invention has high surface coverage rate and sulfonic acid group modification degree, shows excellent separation selectivity for at least 15 rare earth elements, and can be used in macro preparation of high-purity rare earth.

A versatile and efficient method is described for recovering a high-purity material (target) or multiple materials (targets) from a complex mixture in batch or continuous chromatography systems. If perfectly selective sorbents are available for the targets, constant-pattern batch capture methods in tandem or tandem carousel capture methods are preferred. If perfectly selective sorbents for the targets are unavailable, the batch capture, carousel capture, isocratic SMB, non-isocratic SMB, and isotachic displacement methods can be deployed in tandem or in parallel to produce high purity products with high yields and high productivity.

The disclosure provides methods for analyzing two or more different proteins co-formulated in a sample mixture. The methods involve cation exchange-high performance liquid chromatography (CEX-HPLC), size exclusion ultra high performance liquid chromatography (SE-UHPLC), and / or capillary electrophoresis (CE) optimized to accurately determine the concentration, and assess certain critical quality attributes of, each protein in the sample.

Methods, devices, and systems are disclosed that capture carbon dioxide from ambient air and / or point source emissions and produce carbon dioxide from the captured atmospheric and / or point source carbon dioxide using one or more products of the carbon capture processes. Implementations filter atmospheric and / or point source impurities during the carbon capture process and in steps for producing a CO2 stream via chemical synthesis and optionally thermal generation. The integration of CO2 removal processes and chemical synthesis of CO2 synergistically combine to reduce and / or eliminate waste streams, resulting in efficient processes with low carbon emissions and reduced waste.

A waste extraction system that includes a column set positioned between and fluidly coupled to an upstream segment of a main waste pathway and a column effluent tank, the column set having a uranium adsorption column fluidly coupled to a supporting adsorption column along the main waste pathway. The uranium adsorption column is upstream the supporting adsorption column. The waste extraction system also includes a strip waste pathway extending from the uranium adsorption column to the column effluent tank bypassing the supporting adsorption column, an anion exchange resin housed in the uranium adsorption column, and a cation exchange resin housed in the supporting adsorption column.

To provide methods of reducing bioburden of a chromatography resin.SOLUTION: Provided herein are methods that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least one alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol is present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after / upon exposure to the dose of gamma-irradiation. Also provided are: reduced bioburden chromatography columns including the reduced bioburden chromatography resin; compositions including a chromatography resin and a liquid including at least one alcohol; and methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns.SELECTED DRAWING: Figure 1