649results about "Anion exchanger materials" patented technology

A method is provided, comprising: obtaining, for a chromatography machine including a first dispersed plug flow reactor (DPFR) and a continuous stirred tank reactor (CSTR) prior to a column, and a second DPFR after the column, geometric measurements associated with the second DPFR; generating, by a processor, transport model parameters for a transport model associated with the second DPFR based on the geometric measurements; feeding a tracer molecule into the chromatography machine; capturing one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine; and estimating, by the processor, based on the transport model associated with the second DPFR and the one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine, one or more transport model parameters for a transport model associated with the first DPFR and the CSTR.

The invention discloses a method for extracting a target product from a milk raw material, and relates to the technical field of food processing. According to the method, before strong anion exchange chromatography is carried out, a synergistic pretreatment step of ultrafiltration and conductivity adjustment is introduced, so that acceleration, synergism, quality improvement and cost reduction of the chromatography process are realized, and the technical bottlenecks of low speed, easiness in pollution, instability and the like of the traditional ion exchange chromatography during treatment of milk raw materials are overcome; and a solution is provided for high-efficiency, high-purity and large-scale production of the beta-lactoglobulin and the alpha-lactalbumin. According to the method, strong anion exchange chromatography and weak anion exchange chromatography can be combined, so that the extraction purity of beta-lactoglobulin and alpha-lactalbumin can be further improved; in addition, the method can synchronously realize high-efficiency extraction of various target substances such as casein micelles, lactose and milk mineral salts, so that the additional value and resource utilization efficiency of milk source byproducts are greatly improved.

The present invention provides a kit and a detection method for synchronously detecting catecholamines and their metabolites, which relates to the technical field of analytical detection. The kit contains a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device, and a solid-phase extraction packing material. Among them, the solid-phase extraction packing material creatively adopts zwitterionic exchange microspheres containing both carboxyl and quaternary ammonium groups. The kit can not only synchronously and efficiently separate and detect 8 kinds of catecholamines and their metabolites in urine samples, but also separate and detect 6 kinds of amino-containing catecholamines and their metabolites in blood samples. When the above kit is used to separate and detect catecholamines and their metabolites, the extraction recovery rate is relatively high, and the linear range covers the reference value range of normal detection, which can significantly shorten the detection time of urine samples, improve the detection efficiency of mass spectrometry, and is conducive to popularization and application in clinical detection.

The present disclosure provides various characteristics for treating tail brine extracted from a bromine plant, when said brine contains residual bromine and chlorine with low pH and high ORP values that will be used in a lithium extraction production facility. The method conditions the extracted tail brine by adding either sodium hydroxide or ammonium hydroxide to bring its pH levels to between 5.5 and 6.5. The conditioned tail brine then gets pre-treated with hydrazine in either less than 70 ppm if used in combination with sodium hydroxide; or 195 ppm if used with ammonium hydroxide until the ORP levels have reached to below 100 mV. The extracted tail brine is then processed through DLE processing device having four groups of adsorption columns filled with lithium adsorption resins that, after treating the extracted tail brine, discharges the raw eluate solution to an effluent tail brine tank using an effluent tail brine pump connected to the DLE processing device.

A full solid-waste micro-expansive concrete and its preparation method are provided, and relate to the field of concrete material technologies. The full solid-waste micro-expansive concrete includes the following components in parts by weight: 920-1060 parts of a coarse aggregate, 460-582 parts of a fine aggregate, 11-19 parts of an expansive agent, 389-512 parts of a modified solid-waste-based cementitious material, and 231-268 parts of water. The coarse aggregate is coal gangue. The fine aggregate is waste ceramic. The modified solid-waste-based cementitious material includes a solid-waste-based clinker, modified polyvinyl alcohol, and a modified anion exchange resin. The solid-waste-based clinker is prepared from the coal gangue, carbide slag, and desulfurization gypsum. The expansive agent is obtained by calcining the carbide slag. The concrete prepared can ensure the initial strength of the concrete, and guarantee continuous micro-expansion in the later stage, compensating for shrinkage and thereby increasing the overall strength of the concrete.

This invention discloses a method for preparing a high-temperature resistant, strongly basic anion exchange resin, belonging to the field of ion exchange resins. The method includes three steps: First, white spheres with a crosslinking degree of 6-10 undergo a chloromethylation reaction by sequentially adding zinc dichloride and tin tetrachloride to improve the uniformity of the chloromethyl group distribution in the chlorospheres; second, the chlorospheres undergo an etherification reaction using tetrabutylammonium bromide as a phase transfer catalyst, and the dropping rate of sodium methoxide solution is controlled to improve the etherification conversion rate; finally, the etherification product undergoes a quaternization reaction with a trimethylamine aqueous solution to obtain the strongly basic anion exchange resin. This invention, by selecting the degree of crosslinking and optimizing the catalyst addition method for chloromethylation and the sodium methoxide dropping rate for the etherification reaction, results in a more uniform distribution of quaternary ammonium groups in the resin, significantly improving the ion exchange capacity and high-temperature resistance of the resin.

Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

The invention provides a production process of SEMI-G5-grade high-purity NMP (N-Methyl Pyrrolidone), which is characterized in that metal ions, magnetic foreign / non-magnetic foreign particulate matters and the like of conventional industrial-grade NMP are completely removed by adopting a multi-section rectification, resin adsorption and precise filtration process, so that the SEMI-G5-grade NMP reaches the SEMI-G5 grade in an ultra-clean high-purity reagent; and the use requirements on the ultra-clean high-purity NMP in the fields of semiconductors, integrated circuits and novel display are met.

The invention discloses a strongly acidic cation exchange chromatography material and a preparation method thereof. The chromatography material takes microspheres as a matrix material, and takes halogenated alkyl sodium benzenesulfonate and hydroxyl-containing halogenated alkyl sodium sulfonate as functional groups. The preparation method comprises the following steps: epoxy activation: dispersing microspheres in a continuous phase, adding a reducing agent, an alkaline solution and a grafting reagent, and reacting to obtain epoxy activated microspheres; preliminary sulfonation: enabling the epoxy activated microspheres to react with hydroxyl-containing halogenated alkyl sodium sulfonate serving as a first sulfonating agent under an alkaline condition to obtain preliminarily sulfonated microspheres; deep sulfonation: enabling the preliminarily sulfonated microspheres to react with halogenated sodium alkyl benzene sulfonate serving as a second sulfonating agent to obtain a target product. The strongly acidic cation exchange chromatography material provided by the invention can achieve the effects of high protein adsorption capacity and high ion exchange site density.

The invention relates to benzenesulfonic functionalized silica gel as well as a preparation method and application thereof, and the preparation method comprises the step of reacting silica gel with 2-(4-chlorosulfonylphenyl) ethyl trichlorosilane in a solvent to obtain the benzenesulfonic functionalized silica gel. The benzenesulfonic acid group functionalized silica gel provided by the invention has high surface coverage rate and sulfonic acid group modification degree, shows excellent separation selectivity for at least 15 rare earth elements, and can be used in macro preparation of high-purity rare earth.

A versatile and efficient method is described for recovering a high-purity material (target) or multiple materials (targets) from a complex mixture in batch or continuous chromatography systems. If perfectly selective sorbents are available for the targets, constant-pattern batch capture methods in tandem or tandem carousel capture methods are preferred. If perfectly selective sorbents for the targets are unavailable, the batch capture, carousel capture, isocratic SMB, non-isocratic SMB, and isotachic displacement methods can be deployed in tandem or in parallel to produce high purity products with high yields and high productivity.

Methods, devices, and systems are disclosed that capture carbon dioxide from ambient air and / or point source emissions and produce carbon dioxide from the captured atmospheric and / or point source carbon dioxide using one or more products of the carbon capture processes. Implementations filter atmospheric and / or point source impurities during the carbon capture process and in steps for producing a CO2 stream via chemical synthesis and optionally thermal generation. The integration of CO2 removal processes and chemical synthesis of CO2 synergistically combine to reduce and / or eliminate waste streams, resulting in efficient processes with low carbon emissions and reduced waste.

A waste extraction system that includes a column set positioned between and fluidly coupled to an upstream segment of a main waste pathway and a column effluent tank, the column set having a uranium adsorption column fluidly coupled to a supporting adsorption column along the main waste pathway. The uranium adsorption column is upstream the supporting adsorption column. The waste extraction system also includes a strip waste pathway extending from the uranium adsorption column to the column effluent tank bypassing the supporting adsorption column, an anion exchange resin housed in the uranium adsorption column, and a cation exchange resin housed in the supporting adsorption column.

To provide methods of reducing bioburden of a chromatography resin.SOLUTION: Provided herein are methods that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least one alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol is present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after / upon exposure to the dose of gamma-irradiation. Also provided are: reduced bioburden chromatography columns including the reduced bioburden chromatography resin; compositions including a chromatography resin and a liquid including at least one alcohol; and methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns.SELECTED DRAWING: Figure 1

A method is provided of continuous manufacturing of Actinium-225 from a radium generator by repeating chemical purification is provided.

The invention provides a tungsten adsorption-desorption system, comprising: a feeding pipeline, which is respectively communicated with a sulfuric acid feeding pipe, a pure water feeding pipe, a sodium hydroxide feeding pipe and a lepidolite leachate feeding pipe; the bottom of the first HP1053 resin column is communicated with the feeding pipe through a first pipeline, a first electromagnetic valve is arranged on the first pipeline, and the bottom of the first HP1053 resin column further comprises a first waste discharge pipeline; the bottom of the first HP1053 resin column is communicated with the feeding pipe through a first pipeline, the bottom of the second HP1053 resin column is communicated with the feeding pipe through a second pipeline, a second electromagnetic valve is arranged on the second pipeline, the bottom of the second HP1053 resin column further comprises a second waste discharging pipeline, and the top of the first HP1053 resin column is communicated with the top of the second HP1053 resin column through a third pipeline. A third electromagnetic valve and a fourth electromagnetic valve are arranged on the third pipeline; and the discharging pipeline is communicated with the third pipeline between the third electromagnetic valve and the fourth electromagnetic valve, and a fifth electromagnetic valve is arranged on the discharging pipeline.

Anion exchange polymers comprise a plurality of repeating units of formula (I). The polymer may be synthesized from a super acid catalyzed polyhydroxyalkylation reaction of monomers Ar1′, Ar2′, and X1′ to form a neutral precursor polymer followed by a Menshutkin reaction to convert the neutral precursor polymer to the anion exchange polymer.Anion exchange membranes and membrane electrode assemblies incorporating the anion exchange polymers are also described.

The present invention relates to a method for isolating Glu-Plasminogen from a solution containing Glu-Plasminogen and one or more other polypeptides, wherein the method comprises the step of eluting the Glu-Plasminogen from the cation exchange solid phase with an elution buffer of a pH in the range of 6.2 to 6.5. Furthermore, the present invention relates to a composition comprising Glu-Plasminogen obtainable from the method of the invention.

The present invention relates to methods and devices for isolating one or more biomolecules of interest from a biological composition. Specifically, the invention relates to the separation of one or more target biomolecules from a biological composition by dynamic packed bed adsorption using a separation medium comprising porous rod-like particles attached to the target molecules and filtration using a filter having a pore size of at least 1.5 [mu] m.

A substantially animal-protein free (APF) composition comprises a botulinum toxin serotype A neurotoxin having a molecular weight of 150 kDa, comprising one nanogram or less of residual nucleic acid for each milligram of the botulinum neurotoxin component, wherein the botulinum toxin serotype A neurotoxin is obtainable by a process comprising the steps of (a) providing a substantially APF fermentation medium; (b) fermenting Clostridium botulinum bacteria in the fermentation medium, and; (c) recovering the biologically active botulinum neurotoxin from the fermentation medium by contacting the fermentation medium with an anion exchange chromatography media followed by contacting an eluent from the anion exchange chromatography medium with a cation exchange chromatography media.

The present application provides a chromatographic baseline suppression device and a manufacturing method thereof, the chromatographic baseline suppression device comprises a container and two ion exchange membranes, the two ion exchange membranes divide the inside of the container into a first part, a second part and a third part, the second part has an inlet and an outlet; the chromatographic baseline suppression device further comprises two electrodes respectively in the first part and the second part, the electrodes comprise a matrix porous material layer and a polymer layer, the matrix porous material layer is conductive and is connected with the ion exchange membrane. The present application has the advantages of small noise and the like.

The present invention discloses two component cross-linked copolymers in bead form wherein the cross-linked copolymer of the first component formed in the first step has lower cross-linker content than the cross-linker content in the cross-linked copolymer of the second component formed in the second step. These beads are further functionalized to yield strong acid cation exchange resins, strong base anion exchange resins and weak acid cation exchange resins. Ion exchange resins so synthesized exhibit operating exchange capacity (OEC) to total exchange capacity (TEC) ratio in the range of 49 to 61% and also retain more than 85% of whole bead count when subject to osmotic shock resistance test to simulate performance in usage. These ion exchange resins offer advantages in applications such as water treatment, condensate polishing, and unit operations in non-water application like drug purification, sugar processing, catalysis etc.

Embodiments described herein relate to recycling of spent lithium battery material. In some aspects, a method can include suspending a lithium source in a solvent containing an oxidation reagent to extract lithium, forming an extracted lithium solution, separating the extracted lithium solution from residual solids of a lithium source, purifying the extracted lithium solution by precipitating and filtering impurities, and precipitating the lithium in the purified lithium solution to generate lithium carbonate (Li2CO3). In some embodiments, the method can further include preprocessing the lithium source to improve kinetics of the lithium extraction. In some embodiments, the preprocessing can include a cutting or shredding step to downsize the lithium source. In some embodiments, the lithium source can include lithium-ion battery waste. In some embodiments, the oxidation reagent can include sodium persulfate (Na2S2O8), potassium persulfate (K2S2O8), ammonium persulfate (NH4)2S2O8, hydrogen peroxide (H2O2), ozone (O3), and / or nitrous oxide (N2O).

The present application relates to the technical field of ion detection, in particular to a high-efficiency anti-interference ion chromatography detection device and method, through sample pretreatment module, the original sample is filtered, enriched and interference shielding processing, effectively removes impurities and shields interfering ions, at the same time, the chromatographic separation module realizes the simultaneous separation of anions and cations under constant temperature conditions, avoids the problems of chromatographic peak overlap and tailing under the traditional single separation mechanism, significantly improves the detection stability and accuracy of complex matrix samples; the eluent supply module generates high-purity eluent online to avoid impurity pollution caused by manual preparation, the detection module reduces the background conductance in the ion flow and converts the ion concentration change into an electrical signal, effectively reduces the baseline noise, meets the high-sensitivity detection requirement of trace ions; the central control unit controls the cooperative work of each module, greatly shortens the analysis time, and is suitable for rapid detection of large quantities of samples.

The application discloses a process for separating and purifying a mixed solution of HCl and NaCl by using a chromatographic technique. Liquid containing HCl and NaCl is loaded into a chromatographic column containing an anion exchange resin, adsorbed, washed, desorbed, and the effluent is collected. The application uses acid retardation and ion exchange mechanism, adopts fixed bed technology, and realizes the purpose of removing NaCl and separating and purifying high-concentration HCl in one step. The whole process does not use acid and alkali, the Na content in the product liquid is lower than the ion chromatography detection limit, the yield of HCl reaches more than 95%, and the average concentration reaches more than 50%. + The application also uses ultrapure water as a desorbent, so that the product elution and resin regeneration are completed at the same time, and the process is simplified.

Systems, methods, and kits for separating CRISPR / Cas components are provided. The systems, methods, and kits utilize ion exchange chromatography to separate CRISPR / Cas components based on the differing charges of CRISPR-Cas components.

One embodiment of the present invention provides a method for purifying a psicose-containing solution, the method comprising the step of passing a psicose-containing solution through an ion exchange resin column filled with a mixed bed ion exchange resin to obtain an ion-purified psicose-containing solution. In one embodiment of the method for purifying the psicose-containing solution, the mixed bed ion exchange resin is a mixture of strongly acidic cation exchange resin and weakly alkaline anion exchange resin, and the weakly alkaline anion exchange resin constituting the mixed bed ion exchange resin has a quaternary ammonium exchange capacity fraction of 0-10%. When the method for purifying the psicose-containing solution according to the present invention is used, not only the conductivity of the psicose-containing solution can be reduced to an acceptable level, but also psicose loss can be minimized by inhibiting conversion of psicose into psicose or other substances due to functional groups of an ion exchange resin. Therefore, the method for purifying the psicose-containing solution according to the present invention is suitable for mass production of high-quality psicose.

The present invention relates to an ion exchange system for use in ion exchange processes, in particular for changing the chemical composition of a solution. The ion exchange system comprises a plurality of fluid-flowable columns, each column having a first inlet / outlet and a second inlet / outlet; and a plurality of media paths, each inlet / outlet being connectable to at least two media paths; each media path having an inlet and the media paths having at least two outlets, with a junction provided between adjacent columns by means of which any number of adjacent columns can be operated in series.