975 results about "Magnetite Nanoparticles" patented technology

The invention provides a modified basalt fiber, a basalt fiber shielding material and a preparation method, and relates to the technical field of fiber composites.The modified basalt fiber comprises an activated basalt fiber, an adhesion layer and an electromagnetic shielding layer, and the surface of the activated basalt fiber is sequentially coated with the adhesion layer and the electromagnetic shielding layer; the adhesion layer comprises polydopamine; the electromagnetic shielding layer comprises magnetic Fe3O4 nano particles and a graphene nano sheet; the mass ratio of the activated basalt fibers to the polydopamine to the magnetic Fe3O4 nanoparticles to the graphene nanosheets is 1 to (0.4 to 0.5) to (0.6 to 1) to (0.1 to 0.25). According to the basalt fiber shielding material provided by the invention, the conductive particles and the magnetic particles are combined, and by optimizing the material components and proportion, a very good electromagnetic wave absorption and shielding effect can be achieved, a wider frequency band shielding effect can be provided, and electromagnetic radiation in various frequency ranges can be effectively covered.

The invention relates to the technical field of soil conditioners, and particularly discloses an intelligent controlled-release core-shell alginate soil conditioner and a preparation method thereof.The conditioner is of a core-shell-layer three-layer structure and comprises a core layer, a middle shell layer and an outer layer, the three layers account for 30%, 40% and 30% of the total weight respectively, and the core layer mainly comprises improved alginate and nutrients; the middle shell layer mainly comprises chitosan and a microbial preparation; and the outer layer mainly comprises modified charcoal and magnetic nano # imgabs0 #. The preparation method comprises the four steps of core layer preparation, middle shell layer coating, outer layer coating and forming post-treatment, and multiple functions of accurate nutrient supply, efficient heavy metal fixation and soil microenvironment regulation and control are achieved through a core-shell-layer three-layer structure design and a pH / temperature / microorganism triple response mechanism by adopting a coaxial electronic injection and layer-by-layer self-assembly technology; the fertilizer has a remarkable improvement effect on sandy soil and saline-alkali soil, and the organic matter increasing rate reaches 40%.

A carbon dioxide (CO2) stream reacts with an amine-modified magnetic nanoparticle in solution to form an amine-CO2 adduct. The solution that includes the amine-modified magnetic nanoparticle is heated by an external alternating magnetic field. The heat provided by the external alternating magnetic field is localized such that only the amine-CO2 adduct is heated to release the CO2, without heating the entire solution. This process helps with the capture and release of CO2 with a significantly reduced energy during the CO2 release step.

The invention discloses a nano system for tumor radioimmunotherapy and a preparation method and application thereof, and belongs to the technical field of biological medicines.The system modifies bacteria outer membrane vesicles (OMVs) through engineering to enable the bacteria outer membrane vesicles to carry magnetite nanoparticles (Fe3O4NPs) and an ATR inhibitor VE822, the Fenton reaction activity of the Fe3O4NPs and the synergistic effect of the ATR inhibitor for inhibiting DNA damage repair are utilized, and the tumor radioimmunotherapy effect is improved. DNA damage is amplified, DNA damage reaction (DDR) is inhibited, generation of hydroxyl radicals (. OH) under radiation is enhanced, radiation resistance of tumor cells is reduced, immune reaction is reactivated, infiltration of effector T cells to tumors is improved, growth of mice tumors is remarkably inhibited, and an effective strategy is provided for tumor radioimmunotherapy.

The invention relates to a double-color magnetic nanoparticle imaging method based on a single-harmonic system matrix, which comprises the following steps: respectively moving two different types of magnetic nanoparticle samples to a central zero magnetic field point, applying a scanning magnetic field to enable the zero magnetic field point to scan the whole imaging field of view, applying an excitation magnetic field to magnetize magnetic nanoparticles, and applying an excitation magnetic field to magnetize the magnetic nanoparticles; acquiring magnetization frequency spectrum signals of the two magnetic nanoparticle samples; the method comprises the following steps: constructing single harmonic system matrixes A1 and A2 based on single harmonic of magnetization spectrum signals of two kinds of magnetic nanoparticle samples; measuring a to-be-measured object formed by the two kinds of magnetic nanoparticles to obtain a measurement magnetization signal U; transversely splicing the single harmonic system matrixes A1 and A2 of the two different types of magnetic nanoparticles to obtain a new single harmonic system matrix A; the concentration distributions c1 and c2 of two different types of magnetic nanoparticles are obtained by combining a new single-harmonic system matrix A with a measurement magnetization signal U, and the concentration distributions of the two different types of magnetic nanoparticles are respectively sent into different color channels to be displayed in different colors. The method has important significance in promoting the application of the magnetic nanoparticle imaging technology in clinical medicine.

The invention relates to a kitchen waste oil recovery treatment method, which comprises: S1, carrying out multi-field synergistic pretreatment: sequentially carrying out ultrasonic wave and high-frequency pulse electric field treatment on waste oil to break an emulsion layer, adding magnetic nanoparticles to adsorb polar impurities, and carrying out magnetic field separation to obtain high-purity oil; s2, supercritical catalytic reaction: under the CO2 supercritical condition, using a core-shell structure composite catalyst to synchronously perform transesterification reaction and glycerol dehydration reaction; s3, dynamic membrane separation: separating biodiesel and glycerol in real time through an intelligent membrane assembly; s4, gradient utilization of energy: recovering reaction waste heat to drive membrane distillation to concentrate wastewater, and using tail gas CO2 for carbonation reaction to generate calcium carbonate. Through four core technologies of multi-field collaborative pretreatment, low-temperature supercritical catalysis, dynamic membrane separation and energy gradient utilization, triple limitations on efficiency, cost and environmental protection in the prior art are remarkably broken through.

The invention belongs to the technical field of magnetic particle imaging, particularly relates to a magnetic particle imaging system and method based on a flexible receiving coil array, and aims to solve the problems that an existing rigid receiving coil is poor in biological surface adaptability and low in signal-to-noise ratio for micro geometric texture imaging. According to the structure, a receiving coil array adheres to the surface of an object to be measured, the receiving coil array and a compensation coil array are distributed on the two sides of a flexible substrate, the receiving coil array is used for receiving magnetic nanoparticle signals, and the partitioned small compensation coil array is used for conducting feed-through interference and electromagnetic interference compensation on a receiving coil; the reconstruction method comprises the following steps: sequentially carrying out Fourier transform on the collected receiving signals, extracting in-phase third harmonics and superposing to obtain processed signals, interpolating to construct a sinogram for Cartesian coordinate distribution, and reconstructing the three-dimensional particle concentration distribution of a measured object by a filtering back projection method. A flexible receiving coil array strategy is adopted, an adaptive reconstruction method is provided, and the imaging signal-to-noise ratio is improved.

The invention belongs to the technical field of environmental protection, and provides a preparation method of an imine-modified functionalized mesoporous magnetic silicon dioxide nano material. The method comprises the following steps: synthesizing Fe3O4 magnetic nanoparticles in a Fe < 2 + > / Fe < 3 + > alkaline hydrolysis system through a coprecipitation method; then coating the magnetic nanoparticles with an amorphous silicon dioxide layer by taking TEOS (tetraethoxysilane) as a silicon source by adopting a sol-gel method, so as to prepare magnetic silicon coated nanoparticles; the prepared nano-particles are subjected to secondary silicon coating guided by a cetyl trimethyl ammonium bromide (CTAB) mesoporous template agent, and mesoporous magnetic silicon nano-particles are formed after calcination; and finally, carrying out surface amination modification on the mesoporous magnetic silicon nano-particles by utilizing an amino silane coupling agent, and then carrying out condensation reaction on the mesoporous magnetic silicon nano-particles and various aldehyde derivatives to construct imine bonds, so as to obtain the imine-modified functionalized mesoporous magnetic silicon dioxide nano-material. The imine-modified functionalized mesoporous magnetic silicon dioxide nano-material formed by the invention has the characteristics of efficient adsorption, rapid magnetic recovery and excellent environmental stability, and can effectively remove polystyrene micro-plastics and organic pollutants in a water body.

The invention belongs to the technical field of magnetic particle imaging, and relates to a magnetic particle imaging method based on mixed-frequency magnetic field excitation, which comprises the following steps: acquiring a dotted magnetic nanoparticle sample and a to-be-imaged object, respectively applying a mixed-frequency excitation magnetic field in an imaging mode to the dotted magnetic nanoparticle sample and the to-be-imaged object, acquiring a mixed frequency magnetic field excitation-based system matrix and a mixed frequency domain magnetization response frequency spectrum signal; and inputting the system matrix and the mixed frequency domain magnetization response frequency spectrum signal into a concentration spatial distribution inversion model to perform concentration spatial distribution inversion of the magnetic nanoparticles, obtaining the concentration spatial distribution of the magnetic nanoparticles in the object to be imaged, and performing magnetic particle concentration distribution imaging. According to the invention, real-time high-resolution magnetic particle imaging can be realized.

The invention relates to the technical field of material preparation, and discloses a magnetic basalt fiber reinforced wear-resistant self-lubricating coating and a preparation method thereof, and a coating and a preparation method thereof, and the preparation method comprises the following steps: step 1, treating short-cut basalt fibers with an acid and / or alkali solution, mixing with an iron salt solution to obtain a reaction solution, carrying out hydrothermal reaction to obtain the magnetic basalt fiber loaded by the magnetic nanoparticles; step 2, adding a filler into the resin matrix solution, dispersing, and grinding to obtain resin slurry; and 3, adding the magnetic basalt fiber in the step 1 into the resin slurry in the step 2, adding a curing agent, and uniformly mixing to obtain the required coating. According to the method, the contact behavior and the abrasion mechanism of a friction pair are optimized, the friction coefficient and the abrasion rate are reduced, the tribological performance of the obtained coating is improved, the service life of a mechanical kinematic pair is prolonged, and the reliability and the stability of equipment operation are improved.

The invention discloses an optical microscopy method, system and device for positioning magnetic nanoparticles, and the method comprises the steps: obtaining an interference pattern generated when laser passes through a to-be-detected sample, and distributing the magnetic nanoparticles in the to-be-detected sample; the interference pattern is formed by interference of incident laser and scattered light of the magnetic nanoparticles; determining a distribution function of the interference pattern, and determining the central position of the magnetic nanoparticle according to the interference pattern and the distribution function; the device comprises a laser, an amplification objective lens, a focusing lens, an imaging unit and a processor, light emitted by the laser passes through a to-be-detected sample to generate an interference pattern, the interference pattern is amplified by the amplification objective lens and focused by the focusing lens to be imaged in the imaging unit, and magnetic nanoparticles are distributed in the to-be-detected sample. According to the embodiment of the invention, micron-sized space positioning of the magnetic nanoparticles can be realized, and the method can be widely applied to the technical field of optical positioning.

Described herein are compositions, systems, and methods for targeted and controlled drug release. In some embodiments, the compositions, systems, and methods may comprise magnetoelectric silica nanoparticles for targeted and controlled release of chemotherapeutic drugs for cancer treatment. In some embodiments, an external magnetic field may be used to release one or more drugs from the magnetoelectric silica nanoparticles. The disclosed compositions, systems, and methods may improve drug targeting and reduce systemic drug toxicity.

The invention discloses pancreatic lipase immobilized composite nano magnetic beads, a preparation method and application, ferroferric oxide is adopted as a magnetic core, dopamine-mediated growth is performed to form a core-shell structure, then the periphery of the core-shell structure is wrapped with a metal organic framework to form the composite nano magnetic beads, and pancreatic lipase is immobilized by using the composite nano magnetic beads as an adsorption carrier. The enzyme loading amount, the repeated utilization rate and the storage stability of the ferroferric oxide nano-particles are remarkably improved, the enzyme immobilization efficiency and the enzyme activity are improved, and meanwhile, the prepared pancreatic lipase immobilized composite nano-magnetic beads have excellent stability and biocompatibility, are green and pollution-free and can be repeatedly used; the composite nano magnetic beads are synthesized by adopting a solvothermal method, the product is easy to separate, the synthesis process is simple, the enzyme immobilization efficiency can be regulated and controlled by regulating and controlling the synthesis process, the structure of an active ligand can be screened and analyzed from natural products with numerous and jumbled components, and the active ligand has a certain lipid-lowering potential and can be used for preparing the nano magnetic beads. The compound can be used as a potential lead compound of lipid-lowering drugs.

The invention provides an easy-to-scale efficient biological magnetic separation system and method and application. The magnetic separation method comprises the following steps: marking a target object in a to-be-detected suspension by adopting magnetic nanoparticles, and putting the marked to-be-detected suspension into a separation container; a modularized magnet array is arranged in the separation container, the modularized magnet array is composed of permanent magnets, and the permanent magnets are assembled into the cuboid modularized magnet array; the surface of the permanent magnet is coated with a polytetrafluoroethylene coating; the modularized magnet array moves in the suspension under the control of a driving magnet arranged outside the separation container to generate a dynamic gradient magnetic field, and a target object is captured by the modularized magnet array under the action of the gradient force of the magnetic field; removing the liquid in the separation container; adding the resuspension into a separation container, and recovering a target object by physical ultrasonic washing; or adding a chemical dissociation solution into the separation container to recover the target object.

The invention belongs to the technical field of microbiological detection, and discloses a composite probe for detecting salmonella enteritidis and a preparation method. The composite probe for detecting the salmonella enteritidis comprises magnetic nanoparticles FeO, wherein the surface of the magnetic nanoparticles FeO is modified with an aptamer apt which is specifically combined with the salmonella enteritidis; the surface of the long afterglow nano particle PLNPs is modified with a DNA (Deoxyribose Nucleic Acid) sequence cDNA (Complementary Deoxyribonucleic Acid) complementary with the aptamer; the aptamer apt and the complementary DNA sequence cDNA are subjected to hybridization to form a composite probe structure FeO-SEapt (at) PLNPs-cDNA (complementary deoxyribonucleic acid). The long afterglow luminescence characteristic of PLNPs (ZnGaO: Cr) is utilized, and an excitation light source is stopped before detection, so that signal acquisition completely avoids autofluorescence of a sample matrix, background fluorescence interference is thoroughly eliminated, and the signal-to-noise ratio is remarkably improved.

The invention discloses a coating, a preparation method and application, and relates to the technical field of anticorrosive coatings. A dry film of the coating comprises 0.1 wt%-6wt% of a lamellar filler; the lamellar filler is prepared by loading magnetic nanoparticles on the surfaces of two-dimensional nanoparticles and coating a layer of high-molecular polymer. After the coating forms a film, a specific magnetic control orientation curing method is matched, so that high dispersion stability and planar orientation arrangement of the two-dimensional nano filler in a resin matrix are realized, and corrosion of water and oxygen to a base material can be effectively blocked. When the thickness of the coating dry film is only 1-2 microns, the coating dry film still has no obvious corrosion phenomenon after being subjected to a neutral salt spray test for 2000 hours. The metal base material with the thin coating thickness has heat conductivity, corrosion resistance and weather resistance, the preparation process is simple, the cost is low, and the metal base material has extremely high market application value.

The invention discloses a preparation method of a demulsifier for oil-water separation of full fermentation broth, and relates to the technical field of demulsifier preparation.The preparation method comprises the steps of magnetic nanoparticle preparation, nanoparticle coating and demulsifier preparation.The preparation method has the advantages that salt is dissolved in a three-neck flask, nitrogen is introduced to discharge oxygen in the solution, and the demulsifier is obtained; according to the preparation method, the magnetic nanoparticles are added into the mixture A, so that the generated nanoparticles can be prevented from being oxidized, the mixture A is added in the process of adding the potassium nitrate and the 2-methylimidazole, and the polydopamine in the mixture A has good adhesion and biocompatibility, so that a'bridge '-like connection effect can be achieved between the magnetic nanoparticles and a subsequently generated nanoparticle coated sample; and polyvinylpyrrolidone can be used as a dispersant to prevent agglomeration of generated nano particle coated sample particles, and polar groups on molecular chains of polyvinylpyrrolidone can generate certain interaction with raw materials in a reaction system to optimize the growth process of the nano particle coated sample.

According to the high-temperature-resistant nitrogen-fixing bacteria microcapsule fertilizer and the preparation method thereof, aiming at the problems of thallus inactivation and nutrient loss in a high-temperature environment, a sodium alginate-chitosan double-layer embedding technology is combined with magnetic nanoparticle modification, and a stable double-layer structure is formed by optimizing the ratio of an embedding material, so that the high-temperature-resistant nitrogen-fixing bacteria microcapsule fertilizer is prepared. The survival rate and activity of the nitrogen-fixing bacteria at high temperature are remarkably improved, and meanwhile, the functions of intelligent nutrient release and magnetic recovery are achieved. The fertilizer is prepared from composite microcapsules, amino acid, humic acid and other raw materials according to a specific ratio through magnetic field orientation treatment, multi-stage mixing, atomization granulation and magnetic field screening processes, the particle size is controlled to be 0.5-3.35 mm, and the shelf life is prolonged to 12 months. The method has the technical effects that trehalose-glycerol / sorbitol synergistically forms a glassy protective film to maintain the stability of thalli, gamma-aminobutyric acid activates nitrogenase gene expression, magnetic nanoparticles construct a photosynthetic symbiotic system to optimize rhizosphere oxygen supply, and silanized FeO nanoparticles fix heavy metal ions through electrostatic adsorption, so that the heavy metal ions in the thalli are effectively adsorbed, and the heavy metal ions in the thalli are effectively adsorbed. And the humic acid buffers the pH fluctuation of the soil, so that the nitrogen fixation efficiency is finally improved by 30-50%, and the crop yield is increased by 15-25%.

The invention provides a preparation method and application of a magnetic biochar adsorption material, and relates to the technical field of biochar adsorption materials. The adsorption material is prepared by taking three kinds of biomass including municipal sludge, straw and antimony ore waste residues as biochar sources and further loading magnetic nano gamma-Fe2O3 particles. In the process, by controlling the mass of the municipal sludge, the straw and the antimony ore waste residues, the composition and performance of the biochar base material in the adsorption material can be regulated and controlled, rich active sites in the sludge and the straw are fully utilized, loading of the magnetic nano gamma-Fe2O3 particles is achieved, and the adsorption efficiency is improved. A microfibril structure in the straw and a high-activity mesoporous carrier in the antimony ore waste residue not only can improve the load rate of the magnetic nano gamma-Fe2O3 particles to a certain extent, but also can be beneficial to diffusion and capture of heavy metal ions in the application process, so that the adsorption rate of the material to the heavy metal ions is improved on the whole.

The invention belongs to the field of adsorption materials, and discloses a porous lignin fiber adsorption material and a production process thereof, the porous lignin fiber adsorption material comprises the following raw materials by weight: 40-60 parts of lignin fiber, 20-30 parts of bamboo fiber, 5-15 parts of chitosan, 5-10 parts of sodium bicarbonate, 5-10 parts of attapulgite, 5-10 parts of zeolite, and 2-5 parts of magnetic nanoparticles; the invention aims to provide the production process of the porous lignin fiber adsorption material, the problems that the existing lignin fiber adsorption material is poor in pore structure, limited in adsorption performance, difficult to separate and the like are solved through an innovative raw material formula and an optimized production process, efficient adsorption of light components in asphalt is realized, the stability of an asphalt mixture is enhanced, and the service life of the asphalt mixture is prolonged. Meanwhile, heavy metal ions, organic pollutants and the like are efficiently adsorbed and rapidly separated, the production energy consumption is reduced, and the environmental protection property and economical efficiency of the process are improved.

The invention discloses a preparation method of Fe3O4 magnetic nanoparticles rich in carboxyl groups on the surface, which comprises the following steps: modifying Fe3O4 nanoparticles by using polyethylene glycol and silicon dioxide to enhance the dispersity and biocompatibility of the magnetic nanoparticles, modifying the surfaces of PEG-Fe3O4 coated SiO2 nanoparticles by using a silane coupling agent containing silane groups and unsaturated double bonds to obtain the magnetic nanoparticles rich in carboxyl groups on the surface, and modifying the magnetic nanoparticles rich in carboxyl groups on the surface by using a silane coupling agent containing silane groups and unsaturated double bonds to obtain the magnetic nanoparticles rich in carboxyl groups on the surface. Then octavinyl-POSS and double bonds on the surfaces of the nano particles are subjected to click modification to form an octahedral cage, 4-mercaptobenzoic acid and double bonds are further subjected to click modification, the surfaces of the nano particles are rich in carboxyl, and a polymer brush rich in carboxyl is constructed. Compared with a conventional streptavidin coupling method, a high-density polymer chain provides a large number of carboxyl active binding sites, so that the streptavidin coupling amount is increased, the antibody coupling rate is increased, and a solution is provided for applications such as high-sensitivity biological detection, efficient targeted drug delivery and stable immunoassay.

The invention belongs to the technical field related to nanometer material testing, and discloses a magnetic nanoparticle relaxation time detection method and an environmental parameter detection method, and the method comprises the following steps: applying an excitation magnetic field around a to-be-detected target mixed with magnetic nanoparticles; obtaining magnetization response generated by the magnetic nanoparticles in any direction of the magnetic field plane, and obtaining phase lag corresponding to any order harmonic term of the magnetization response; according to the function relationship between the phase lag corresponding to any harmonic term and the Brown relaxation time of the magnetic nanoparticles, solving and obtaining the Brown relaxation time of the magnetic nanoparticles; wherein the function relationship comprises a correction term introduced by magnetic dipole interaction of the magnetic nanoparticles. The magnetic dipole interaction among the magnetic nanoparticles is introduced, relaxation time detection of particle space distribution under an external magnetic field is corrected, the interference of the magnetic dipole interaction on the magnetic nanoparticle Brown relaxation time detection process can be effectively reduced, and accurate estimation of the magnetic nanoparticle Brown relaxation time is realized.

A magnetic nanoparticle composite microcapsule, and a preparation method therefor and the use thereof. The preparation method comprises: diluting concentrated ammonia water with absolute ethanol in which nano-Fe3O4 is dispersed, stirring same and adding ethyl orthosilicate, centrifuging same, and then performing washing to obtain Fe3O4 / SiO2 particles; dispersing same in anhydrous ethanol, then adding isopropanol containing tetrabutyl titanate, and performing a treatment to obtain Fe3O4 / SiO2 / TiO2 nanoparticles; adding polyurethane TDI prepolymer to the Fe3O4 / SiO2 / TiO2 nanoparticles, adding same to a core material, then dripping an emulsifier, and stirring same to obtain a core material emulsion; and heating same in a water bath, dropwise adding butanediol, and performing heating, stirring and vacuum filtration to obtain a magnetic nanoparticle composite microcapsule. By means of the loading with a core material having a repair function, the prepared magnetic microcapsule can actively repair damage to an insulating material caused by electrical and mechanical stress, thereby improving the reliability of a device.

The invention discloses a magnetic nanoparticle concentration distribution inversion method and a related device, and relates to the technical field of biomedical engineering.The method comprises the steps that firstly, magnetic nanoparticles in biological tissue are excited through an external magnetic field to generate infinitesimal displacement; and then ultrasonic equipment is adopted to collect ultrasonic ultrafast plane wave imaging data and carry out axial vibration displacement detection, axial vibration displacement actual measurement data and corresponding discrete space and time coordinates are input into the inversion model for iterative inversion, and a magnetic nanoparticle concentration distribution inversion result is obtained. A loss function of the inversion model includes a data-driven loss item and a physical information-driven loss item (based on a Navie equation). Compared with the prior art, the method has the advantages that the physical information neural network is introduced, control equations such as a nano-dimension equation and the like are encoded to the full-connection neural network, physical equations do not need to be excessively simplified, complex and time-consuming modeling for an experimental environment is not needed to obtain simulation data, and higher accuracy and stability are achieved.

The invention relates to the field of demulsifiers, in particular to an oil sludge demulsifier as well as a preparation method and application thereof. The oil sludge demulsifier comprises the following components in parts by mass: 20-35 parts of a surface active compound, 7-12 parts of a sodium alkyl sulfate cosolvent, 0.6-1.8 parts of a stabilizer and 48-55 parts of water, wherein the surface active compound comprises hyperbranched polyamidoamine and polyether amine modified magnetic nanoparticles. According to the oil sludge demulsifier, the problems that most of existing demulsifiers are small in dehydration amount, low in dehydration speed, poor in demulsification effect and low in treated oil content are solved, the demulsification performance of the oil sludge demulsifier is improved, the demulsification and dehydration efficiency is improved, and effective separation of oil sludge is achieved.

The invention provides eye protection liquid for improving eye microcirculation and a preparation method thereof, and belongs to the technical field of medical configuration products. The composition comprises the following components: surface-modified magnetic nanoparticles, a calendula extract, a fermented dogwood extract, xanthophyll, taurine, sodium hyaluronate, hydrolyzed sodium hyaluronate, soya bean lecithin, borneol and fermented vegetable oil. The efficiency of active ingredients is improved through a double-fermentation technology, magnetic targeting and multi-channel compounding are combined, and the preparation method has remarkable advantages in the field of improving periorbital microcirculation. The traditional Chinese medicine composition has an obvious relieving effect on asthenopia and dry skin around eyes; the components of the eye microcirculation eye protection liquid are mild, and adverse reactions such as allergy cannot be caused.

The invention relates to the field of DNA nanotechnology, and discloses a DNA origami structure based on functionalized magnetic nanoparticles, a preparation method and application, and the preparation method comprises the following steps: step 1, constructing a DNA origami structure with a cavity through a self-assembly method; the short chains in the DNA origami structure comprise a first short chain, a second short chain and a third short chain; 2, connecting a sulfydryl-functionalized first sequence to the first short chain, and chelating ferrous ions on the first sequence to obtain a sulfydryl-modified DNA origami structure; 3, ferrous ions chelated on the sulfydryl modified DNA origami structure are reduced, and a magnetic functionalized DNA origami structure internally loaded with Fe2O3 particles is obtained; and 4, connecting an antibody to a second short chain in the DNA origami structure through base complementary pairing to obtain the required DNA origami structure. According to the invention, DNA origami is combined with magnetic nanoparticles, efficient and controllable biological magnetic beads are obtained through dual immobilization and antibody modification, and a traditional application scene of DNA origami is broken through.

This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.

The invention discloses potato starch nano-carrier immobilized lipase and a preparation method thereof, and relates to the technical field of biological catalysis. The immobilized lipase comprises a lipase and a carrier, and the lipase is immobilized on the carrier; the carrier is potato starch modified magnetic nanoparticles. The immobilized lipase provided by the invention takes the magnetic potato starch nanoparticles as a carrier and has the advantages of being green and environment-friendly and easily available in materials, and the lipase is successfully immobilized on the magnetic nanoparticles by using the potato starch and the traditional glutaraldehyde as cross-linking agents. The method not only improves the activity and stability of the immobilized enzyme, but also has good biocompatibility and safety. By optimizing parameters such as potato starch dosage, enzyme concentration and immobilization time, the obtained immobilized enzyme shows excellent storage stability and repeated utilization rate. In addition, the method provides reference for preparation of other high-performance immobilized enzymes.

The invention provides a peptide fragment for modifying a Fe3O4 (at) Au magnetic nanoparticle and a preparation method of the Fe3O4 (at) Au magnetic nanoparticle, the peptide fragment is an alpha-peptide fragment 1 or / and a beta-peptide fragment 1, and the fragment of the peptide fragment is as shown in SEQ ID NO: 1. The method comprises the following steps: firstly, growing a layer of gold shell on the surface of Fe3O4 in situ to provide more modification sites, and then modifying PS binding peptide (PSBP) by using an Au-S bond to construct the PS NPs selective probe. The ultralow-concentration PS can be quantitatively detected only by monitoring the ultraviolet-visible absorption change of the probe. The peptide modified Fe3O4 (at) Au probe (Fe3O4 (at) Au-PSBP) has good linearity in a range of 0 to 80 pg mL <-1 >. The probe has been successfully applied to actual samples, such as bottled water, edible salt and milk. The adding standard recovery rate is 98.85%-112.10%, and the relative standard deviation (RSD) is 2.53%-13.80%. The provided Fe3O4 (at) Au-PSBP can be easily expanded to other types of NPs by simply replacing peptides, shows huge potential as a universal specific probe, and can sensitively and quickly detect low-concentration NPs in an actual sample.