228results about How to "Slow degradation" patented technology

Implantable medical articles having a coating formed of hydrophobic derivatives of natural biodegradable polysaccharides are described. The coatings can include a bioactive agent, and demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The coated implantable medical articles can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.

A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance.

Protection of proteins against fibrillation may be afforded by introduction of certain histidine substitutions into the protein, such that a pair of histidines are present with sufficient spacing as to allow the histidines to coordinate with zinc. In the case of insulin, introduction of histidine residue substitutions at residues A4 and A8 together or a histidine residue substitution at residue B1, provides increased resistance to fibrillation while maintaining at least a majority of the activity of the insulin analogue. Introduction of a histidine residue substitution at residue A8 restores at least a portion of fibrillation resistance that may have been harmed by substitutions present on the B-chain such as those present in fast-acting insulins. Proteins protected by such histidine substitutions may be used to provide a pharmaceutical composition. A method of treating a patient includes administering a physiologically effective amount of the pharmaceutical composition to the patient.

A novel usage of poly-L-lactic acid as medical shape memory material is provided. Forming the poly-L-lactic acid to initial shape under the temperature of 190í½210íµ and pressure of 2í½10Mpa to obtain the poly-L-lactic acid with shape memory property. The present invention uses poly-L-lactic acid as medical degradable shape memory material for the first time. It can be widely applied in minor trauma invasive stent, vessel jointing, operation suture line, bone fracture fixation and other medical field.

The present invention relates to a corrosion-resistant high-toughness zinc-magnesium alloy implanting material capable of being absorbed by human body. The alloy material comprises 96-99.998 wt% of Zn and 0.002-4 wt% of Mg. According to the present invention, the alloy material of the present invention is applied for the absorbable medical implant, particularly the vascular stent and the orthopedic implant (bone nail or bone plate and the like); the prepared zinc-magnesium alloy material of the present invention can be absorbed in the human body environment, such that the pain of the secondary surgery on the patient can be avoided; the corrosion resistance of the prepared zinc-magnesium alloy material is much higher than the corrosion resistance of the magnesium alloy, the degradation speed is substantially reduced, and the long-term mechanical support can be provided, such that the failure of the vascular stent, the bone nail and other implants in advance can be avoided; and the mechanical strength of the prepared zinc-magnesium alloy material is much higher than the mechanical strength of the polymer, and the prepared zinc-magnesium alloy material has characteristics of high toughness, easy manufacturing, good elastic modulus matching with human body, and simultaneous high corrosion resistance and high toughness achieving.

The present invention relates to technical field of biological material, and is especially suitable for surface modification field of biological medical material. Particularly the invention provides a medicine-taking degradable magnesium alloy cardiovascular bracket and a preparing method thereof. The aim of the invention is to reduce the initial degrading speed of magnesium alloy in biosome and carry therapeutic medicine on the surface of magnesium bracket thereby guaranteeing the mechanical performance of magnesium alloy bracket in vivo and better restraining the hyperplasia of newborn tunica interna. A fluoro-containing transition film is prepared on the surface of magnesium alloy bracket, and a medicine-carrying layer is prepared on the outer layer of magnesium alloy bracket. A protecting layer is the fluoro-containing transition film. The fluoro-containing transition film has self-concrescence capability in the degradation process of magnesium alloy and can effectively reduce the in-vivo degradation velocity of magnesium alloy bracket. The surface of degradable magnesium alloy cardiovascular bracket is smooth and is not easily generated with surface cracking and breaking-off. The medicine-taking layer is composed of medicine carrier polymer or protein and therapeutic medicine. The medicine-taking layer can release therapeutic medicine, reduce the generation rate of stenosis after the implantation of bracket and has a control function to the degradation velocity of magnesium alloy bracket.

The invention relates to a method for planting saffron crocus in a Tibet region and belongs to the technical field of natural medicine plantation. The method comprises the steps of field seed ball breeding and indoor cultivation flower picking. The field seed ball breeding comprises the sub-steps of selection of seed corms, plantation preparation, plantation, field management, harvesting of the seed corms and storage of the seed corms. The indoor cultivation flower picking comprises the sub-steps of loading into flat baskets, shelving, cultivation management, and harvesting and processing of the saffron crocus. The saffron crocus is planted in a large field in the Tibet region by using the plantation method, sunlight is sufficient, the plantation time of the seed corms in the land is long, flowers are picked in the land, and the cost is reduced; by virtue of the selection and the cooperation of various plantation parameters according to the technical scheme, filaments of the produced saffron crocus are long, the appearance is good, and the yield is high; the content of saffron crocus essence and saffron crocus bitter principle is greatly higher than that of the saffron crocus produced in the prior art, the medicinal value is high, and pesticide residues are eliminated; moreover, seed balls are large, low in lesion and low in degeneration.

Intercalates, exfoliates thereof, and nanocomposite compositions are formed by intercalating a layered silicate material, e.g., a phyllosilicate, with an oligomer or polymer intercalant that is a reaction product of at least one diamine with at least one dicarboxylic acid, to form a polyamide oligomer containing a xylylenediamine component. The oligomer or polymer may be formed in-situ by contacting the layered phyllosilicate with polymerizable monomer reactants using conditions to cause reaction and polymerization in the intercalating composition and intercalation of the resulting oligomer and/or polymer, between platelet layers of the phyllosilicate. An amine functionality of the oligomer or polymer is protonated for ion-exchange with interlayer cations of the phyllosilicate to bond the intercalant to the phyllosilicate platelet, at the protonated amine, at a negative charge site previously occupied by the interlayer cations.

The invention discloses a method for preparing an anti-oxidation permeated layer on the surface of molybdenum or a molybdenum alloy. The method comprises the following steps: I, polishing the surface of molybdenum or the molybdenum alloy so as to remove oxidized skin on the surface, performing ultrasonic washing, and drying; II, preparing a coating permeation agent; and III, coating molybdenum or the molybdenum alloy into a crucible with the permeation agent, sealing the crucible and putting the crucible into a high-temperature furnace, performing heat-preservation treatment for 1-20 hours at 1000-1500 DEG C in the presence of argon, and performing furnace cooling till the room temperature, thereby obtaining the anti-oxidation permeated layer on the surface of molybdenum or the molybdenum alloy. As the high-temperature furnace is adopted to perform heat-preservation treatment on molybdenum or the molybdenum alloy coated in the permeation agent, the anti-oxidation permeated layer of a multi-layer structure can be formed on the surface of molybdenum or the molybdenum alloy, and the anti-oxidation permeated layer is high in adaptability to the shape of a molybdenum or molybdenum alloy substrate, uniform in thickness of permeated layer, slow in degradation speed of the permeated layer, and has the advantages of simplicity in operation and rapid permeated layer deposition speed.

An apparatus for applying and fusing a powder coating to substrates of various composition uses two lasers to accurately heat the coating to the optimum temperature. A second laser has less power and heats a smaller area than the first laser. Temperature control is enhanced by the ability to superheterodyne two lasers at separate frequencies. This allows for better absorption of certain materials being fused by the laser. Another common problem associated with laser processing occurs as the polymer heats up. During the heating process the spectral lines are Doppler broadened and slightly shifted. This can affect the absorption of a laser of a fixed wavelength. With the present invention, the optimum laser frequency can be turned to a more optimum frequency for absorption still with sufficient power for fast efficient thermal processing.

The invention discloses a preparation method for a sodium alginate-nano silicon dioxide compound film. Through a series of technical means of performing in-situ compounding on sodium alginate and nano silicon dioxide, performing ultrasonic defoaming treatment before film casting, increasing the concentration of sodium alginate by step control in a preparation process, controlling addition time and speed of hydrochloric acid and the like, so that nano silicon dioxide is ideally dispersed in a reaction system, an agglomeration phenomenon is avoided, and the sodium alginate/nano silicon dioxide film which is compact in structure, colorless, transparent, airtight, high in quality, degradable, good in waterproof performance and strong in ultraviolet-proof capability, has comprehensive performance indexes and is suitable for food packaging is prepared. Compared with the prior art, the preparation method has the characteristics of simple and easily controlled process, low preparation cost and the like.

The invention relates to a stable potassium sodium dehydroandroan drographolide succinate compound and a pharmaceutical composition thereof. The compound is prepared by the following steps: adding potassium dehydroandrograpolide succinate in an ethanol solution, and stirring to obtain a white suspending liquid; at room temperature under normal pressure adding sodium bicarbonate solution dropwisely with introducing nitrogen and stirring for reacting until clear to obtain a yellow solution; cooling the yellow solution, then precipitating crystals; carrying out recrystallization 1-3 times on thecrystals with a mixed solution, and simultaneously decoloring with active carbon to obtain white crystals, wherein, the mixed solution comprises ethyl acetate and ethanol, and the ratio of ethyl acetate to ethanol is 2 to 1.

Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the FGFR2 gene and its expression products. The present invention is directed to nucleotide sequences, amino acid sequences, probes, and primers related to FGFR2 activation mutants and kits comprising these mutants to diagnosis and classify endometrial cancer in a subject.

The invention relates to a biological paster for skin regeneration and maintenance. The biological paster has different release gradients and has the better skin regeneration and cosmetic effect. The biological paster is composed of two parts which are cooperated to be used. One part comprises a base and a plurality of micro needles located on the base. The other part comprises a back coating, namely a gel cold compress layer. A first soluble micro needle array and a second soluble micro needle array are arranged on the upper surface of the base and have different dissolution speeds. The first micro needle array comprises a plurality of first micro needles, and the second micro needle array comprises a plurality of second micro needles.

The present invention relates to novel plants, in particular to Capsicum annuum plants capable of producing fruits with extended storability after full coloring of the fruit, and to seeds and fruits of said plants. The present invention also relates to methods of making and using such plants and their fruits. In particular, fruits of plants of the present invention retain marketability over extended periods of time compared to presently available peppers.

The invention relates to a method for preparing a hydroxyapatite and bone collagen composite coating on the surface of a magnesium alloy. The method comprises the following steps: preparing a deposition solution, wherein in the deposition solution, the concentration of calcium nitrate is 0.02-0.05 mol/L, the concentration of sodium phosphate is 0.002-0.005 mol/L, the concentration of bone collagen is 0.5-2.0 g/L, and the pH value of the deposition solution is 3.0-4.0; carrying out ultrasonic cleaning on the magnesium alloy for 8-10 min in alcohol and acetone after polishing treatment, and then putting the magnesium alloy in the deposition solution for deposition for 6-24 h, wherein ultrasonic oscillation with the power of 100-150 W and the frequency of 30-45 KHz is adopted in the initial stage of deposition for 5-15 min. The preparation method is simple, the prepared and obtained hydroxyapatite and bone collagen composite coating is low in degradation velocity, the biomedical magnesium alloy with the coating is higher in corrosion resistance, and the bone collagen is added into the deposition solution, so that the nucleation and growth of the hydroxyapatite can be quickened, and the corrosion resistance of materials is improved.

The invention relates to a chlorine dioxide solution and in particular relates to a high-efficiency chlorine dioxide solution without activation as well as a preparation method and application thereof. The chlorine dioxide solution is mainly prepared from the following components in parts by weight: 30-40 parts of chlorite, 20-40 parts of an activating agent, and 10-20 parts of a halogen oxidant, wherein the content of chlorine dioxide gas in the solution is 600ppm or higher. According to the high-efficiency chlorine dioxide solution provided by the invention, a principle component of the solution is the chlorine dioxide gas, activation is not needed during use, and the solution can be directly used or used after dilution, and is safe and convenient; the solution can be preserved for 6 months or longer at a normal temperature, can be preserved for 18 months or longer at a temperature of 4 DEG C and is long in preservation period; the halogen oxidant in the solution can achieve a synergistic effect with the chlorine dioxide gas, so that the disinfection and sterilization effects of the chlorine dioxide can be improved, and the disinfection and sterilization effects are lasting and obvious. Therefore, the high-efficiency chlorine dioxide solution disclosed by the invention is safe, convenient, long in preservation period, and lasting and obvious in disinfection and sterilization effects.

The invention discloses a soil heavy metal curing agent for controlling accumulation of heavy metals of crops and a preparation method thereof, and belongs to the technical field of a fertilizer. The production method comprises the following materials in parts by weight: 60-140 parts of polyisoprene, polyisoprene analogue or polyisoprene derived polymer, 50-400 parts of sulfocompound, 50-500 parts of organic material in terms of water content of 10%, 0-400 parts of water, 0-100 parts of initiator, 0-200 parts of reducing agent, and 0-200 parts of alkali. The soil heavy metal curing agent disclosed by the invention can reduce the content of cadmium, lead and mercury in a soil solution; and absorption of roots on these heavy metals is greatly reduced.