Method for preparing hydroxyapatite and bone collagen composite coating on surface of magnesium alloy

A technology of bone collagen and hydroxyapatite, applied in metal material coating process, coating, liquid chemical plating and other directions, can solve the problems of low corrosion resistance, fast degradation speed, good corrosion resistance of magnesium alloys, etc. , to achieve the effect of good corrosion resistance, low degradation rate and improved corrosion resistance

Active Publication Date: 2015-03-11
WUXI GUANGXU STEEL SHEET
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the shortcomings of low corrosion resistance and fast degradation speed of biomedical magnesium alloys in the prior art when they are u

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing hydroxyapatite and bone collagen composite coating on surface of magnesium alloy
  • Method for preparing hydroxyapatite and bone collagen composite coating on surface of magnesium alloy
  • Method for preparing hydroxyapatite and bone collagen composite coating on surface of magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1:

[0023] First, add 0.95g of calcium nitrate tetrahydrate into 180mL of distilled water, stir to dissolve it completely, then add 0.16g of sodium phosphate to obtain a turbid solution, then add 65-68% nitric acid and stir to make the turbid solution clear, add 0.1g of collagen, add distilled water, and dropwise add nitric acid solution with a concentration of 65-68% and sodium hydroxide solution with a concentration of 1 mol / L to adjust the pH value to 4.0, and adjust the total volume of the solution to 200 mL to obtain a solution containing 0.02 mol / L. L calcium nitrate, 0.002mol / L sodium phosphate and 0.5g / L collagen deposition solution;

[0024] The biomedical magnesium alloy sheet was first polished with sandpaper, then ultrasonically cleaned with alcohol and acetone for 8 min each, and the magnesium alloy sheet was immersed in a water bath heated to 40 °C for 24 h of deposition. Ultrasonic vibration of 40KHz for 5min;

[0025] After the depositio...

Example Embodiment

[0027] Embodiment 2:

[0028] First, add 2.36g of calcium nitrate tetrahydrate into 180mL of distilled water, stir to dissolve it completely, then add 0.39g of sodium phosphate to obtain a turbid solution, then add 65-68% nitric acid and stir to make the turbid solution clear, add 0.2 g of collagen, add distilled water, adjust the pH to 3.0 with 65-68% nitric acid and 1 mol / L sodium hydroxide, and adjust the total volume of the solution to 200 mL to obtain a solution containing 0.05 mol / L calcium nitrate, 0.005 mol / L sodium phosphate and 1.0g / L collagen deposition solution;

[0029] The biomedical magnesium alloy sheet was first polished with sandpaper, then ultrasonically cleaned with alcohol and acetone for 10 min each, and then the magnesium alloy sheet was immersed in a water bath and heated to 40 °C for 8 h of deposition. In the initial stage of deposition, the power was 150W, Ultrasonic vibration with a frequency of 40KHz for 15min;

[0030] After the deposition was ...

Example Embodiment

[0032] Embodiment three:

[0033] First, add 1.43g of calcium nitrate tetrahydrate into 180mL of distilled water, stir to dissolve it completely, then add 0.19g of sodium phosphate to obtain a turbid solution, and then add 65-68% nitric acid and stir to make the turbid solution clear, add 0.2 g of collagen, add distilled water, adjust the pH to 4.0 with 65-68% nitric acid and 1 mol / L sodium hydroxide, and adjust the total volume of the solution to 200 mL to obtain a solution containing 0.03 mol / L calcium nitrate, 0.0025mol / L sodium phosphate and 1.0g / L collagen deposition solution;

[0034] The biomedical magnesium alloy sheet was first polished with sandpaper and cleaned with alcohol and acetone ultrasonically for 10 min, and then the magnesium alloy sheet was immersed in a water bath and heated to 40 °C for 24 hours of deposition. Ultrasonic vibration of 40KHz for 10min;

[0035] After the deposition was completed, the biomedical magnesium alloy sheet was taken out and w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a method for preparing a hydroxyapatite and bone collagen composite coating on the surface of a magnesium alloy. The method comprises the following steps: preparing a deposition solution, wherein in the deposition solution, the concentration of calcium nitrate is 0.02-0.05 mol/L, the concentration of sodium phosphate is 0.002-0.005 mol/L, the concentration of bone collagen is 0.5-2.0 g/L, and the pH value of the deposition solution is 3.0-4.0; carrying out ultrasonic cleaning on the magnesium alloy for 8-10 min in alcohol and acetone after polishing treatment, and then putting the magnesium alloy in the deposition solution for deposition for 6-24 h, wherein ultrasonic oscillation with the power of 100-150 W and the frequency of 30-45 KHz is adopted in the initial stage of deposition for 5-15 min. The preparation method is simple, the prepared and obtained hydroxyapatite and bone collagen composite coating is low in degradation velocity, the biomedical magnesium alloy with the coating is higher in corrosion resistance, and the bone collagen is added into the deposition solution, so that the nucleation and growth of the hydroxyapatite can be quickened, and the corrosion resistance of materials is improved.

Description

technical field [0001] The invention relates to a method for preparing a composite coating of hydroxyapatite and bone collagen on the surface of a magnesium alloy, and belongs to the technical field of preparation of biomedical materials. Background technique [0002] As a metal material that can be degraded and absorbed, biomedical magnesium alloy can be completely absorbed by the human body when it is used for the repair of human hard tissues, avoiding the pain caused by the second removal operation. However, a key problem limiting the application of magnesium alloys is that the corrosion resistance of magnesium alloys is low, and their degradation speed is too fast, especially in solutions containing chloride ions. Therefore, calcium phosphate coating should be prepared on the surface of biomedical magnesium alloy. At present, the surface coating of magnesium alloy is mostly a single coating, and the most widely used is apatite coating, but the corrosion resistance of th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C23C18/16A61L27/42
CPCA61L27/42C23C18/1601
Inventor 包全合张洁清付平朱云
Owner WUXI GUANGXU STEEL SHEET
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap