1896 results about "Hydroxyapatites" patented technology

An improved bone graft is provided for human implantation, bone graft includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the bone graft provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The bone graft may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.

This invention relates to novel room-temperature process for obtaining calcium phosphate, in particular hydroxyapatite, coatings and microspheres that encapsulate drugs, proteins, genes, DNA for therapeutical use. The coatings and microspheres are designed to perform a defined biological function related to drug delivery, such as gene therapy through gene delivery. A novel method for encapsulation, and subsequent controlled release of therapeutically active agents from such biofunctional coatings and microspheres is disclosed. Such coatings and microspheres are useful for side-effects free, long-term, targeted, controlled release and delivery of drugs, proteins, DNA, and other therapeutic agents.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

The spinal cage comprises a structural component having sufficient strength to withstand the compressive loading between vertebral bodies. The structural component is integrated with an osteoconductive component to facilitate bone growth between the vertebral bodies. The structural component may comprise any of PEEK, PEKK, or other structural material. The osteoconductive component may comprise any of allograft, natural bone, tricalcium phosphate, hydroxyapatite or a blend of calcium carbonate, calcium lactate and other calcium salts. A method for making the spinal cage involves molding polymers around an osteoconductive component, heat staking, and may further include ultrasonically welding, snap fit or mechanically assembling and/or adhesively bonding components.

Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, poldioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches.

Component 2, a dispersing vehicle, may be esters of C₈-C₁₈ monohydric alcohols with C₂-C₆ aliphatic monocarboxylic acids; C₂-C₁₈ monohydric alcohols with polycarboxylic acids; C₈-C₃₀ monohydric alcohols; tocopherol and esters thereof with C₂-C₁₀ aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; alkyl aryl ethers and ketones, polyhydroxy compounds and esters and ethers thereof; (ethylene oxide/propylene oxide copolymers), oils e.g. olive oil, castor oil and triglycerides.

Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.

Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

Ceramic materials operable to repair a defect in bone of a human or animal subject comprising a porous ceramic scaffold having a bioresorbable coating, and a carrier comprising denatured demineralized bone. The ceramic may contain a material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium phosphates, calcium carbonates, calcium sulfates, and combinations thereof. The compositions may also contain a bone material selected from the group consisting of: bone powder, bone chips, bone shavings, and combinations thereof. The bioresorbable coating may be, for example, demineralized bone matrix, gelatin, collagen, hyaluronic acid, chitosan, polyglycolic acid, polylactic acid, polypropylenefumarate, polyethylene glycol, or mixtures thereof.

Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.

The present invention is a bioactive endodontic material and its use for filling the tooth and bone cavities. The present invention, by using calcium salt, calcium oxide, calcium silicate, and calcium phosphate compounds as essential constituents, and mixing them with a water base solution, prepares a bioactive calcium and phosphate enriched material. The enriched material (cement) comprises high concentration of water-soluble calcium and phosphate, and immediately forms hydroxyapatite during and after setting. The cement is biocompatible, antibacterial, capable to form an effective seal against reentrance of microorganisms into the filled cavity, compatible to handle and set in an aqueous environment, and able to stimulate hard tissue healing.

The invention discloses a composite heavy metal polluted soil conditioner as well as application and an application method thereof. The soil conditioner comprises the following components: plant ash, calcium magnesium phosphate, quicklime, zeolite and organic fertilizers at a weight ratio of (0.3-1.1):(0.1-1.2):(0.4-2.1):(0.1-0.6):(0.008-0.06):(0.4-1.2). Through inorganic components such as quicklime, calcium magnesium phosphate and phosphate in hydroxyapatite as well as potassium carbonate in the plant ash, the soil conditioner can be used for fixing heavy metals in polluted soil and improving the fertility of the polluted soil in combination with organic manures such as the plant ash and the organic fertilizers so as to continuously intensify the restoration of the polluted soil, has the advantages of relatively-high stability, good environmental friendliness and low cost, can be used for inactivating and restoring various heavy metal polluted soil, especially has a good restoration effect on soil pollution caused by waste slag discharged by industrial and mining enterprises, can be used for realizing the treatment goal without generating secondary pollution, and is liable to realize large-area popularization.

The present invention provides machinable calcium phosphate bone substitute material implants having mechanical properties comparable to those of natural bone. The implants include intimately mixed solid precursor materials that react under physiological conditions to form poorly-crystalline hydroxyapatite and eventually are remodeled into bone in vivo. The implants can include a biocompatible polymer to increase density and strength and control resorbability.

A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.

A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

The integral engineering rack of interface osteochondro tissue with bionic interface includes from the top to the bottom one cartilage layer, one calcified layer and one bone layer below cartilage connected organically. The cartilage layer consists of type II collagen and chitosan connected in covalent bond; the calcified layer consists of type II collagen and hydroxyapatite connected in covalent bond; the bone layer below cartilage consists of type I collagen and hydroxyapatite connected in covalent bond; and each of the cartilage layer and the bone layer below cartilage has at least one pore of 100-500 micron size. The integral engineering rack of the present invention has excellent biocompatibility, excellent degradability, sufficient mechanical first and bionic interface function.

An osteoinductive bone graft substitute composition that does not return to its original shape upon hydration or manipulation is disclosed, comprising, in combination, about 86-89% by weight of a calcium phosphate particulate mineral component and about 11-14% by weight of a purified fibrillar collagen, the mineral component including about 20% to about 60% by weight of hydroxyapatite and about 60% to about 20% by weight of tricalcium phosphate. A package configured to store a bone graft composition is disclosed, comprising an inner sterile polymeric V-shaped pouch located in an outer sterile polymeric V-shaped pouch. Methods for repairing a bone defect in a patient are disclosed using the osteoinductive bone graft substitute composition.

The invention discloses an adsorption method for preparing hydroxyapatite pesticide and slow-release fertilizer compound, which comprises the following steps: soaking a nano hydroxyapatite carrier in phosphate buffer solution, then adding a starting material into the buffer solution and continuously stirring the mixture to form compound solution, finally centrifuging the compound solution to obtain sediment, and drying the sediment to obtain the compound. By using a porous structure of the nano hydroxyapatite self to embed medicaments into an internal grid of the carrier, the burst effect of the medicaments is avoided, the medicinal effect is long, the medicament residue is greatly reduced, and the medicaments are safer. A product obtained by using the nano hydroxyapatite as a pesticide and fertilizer carrier has the advantages of reliable quality, strong stability, safe use and low cost, greatly improves the medicament loading amount and adsorption amount, is easy for continuous production, and has good application prospect.

An edible and/or chewable article of manufacture containing at least one food grade substance having adsorption affinity towards at least one dental plaque (biofilm) constituent and capable of reducing and/or removing the oral biofilm while present in the mouth. Particular articles of manufacture are chewing gums, sweets, candies, candy, and other nutritional bars, ice creams, chocolates, confectionery and bakery/pastry products, honey, dairy products and beverages, and oral hygiene products such as tooth pastes, oral gels and mouthwashes. A chewing gum having a conventional gum base and at least one food grade active substance having adsorption affinity towards at least one dental plaque (biofilm) constituent (bacteria and proteins and bacterial cell-free enzymes) and capable of reducing and/or removing the oral biofilm while present in the mouth. Active substances include polysaccharides and non-toxic salts thereof, such as alginates, chitosan, carboxymethylcellulose, agar and carrageenan, inorganic substances such as silica, hydroxyapatite and calcium carbonate and proteins, particularly gelatin and lectin. The article of manufacture removes and/or for prevents or reduces dental plaque (biofilm), and controlling oral, dental and periodontal diseases.

A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

Disclosed is a make-up composition comprising by weight: from about 1% to about 20% of a sebum solidifying powder comprising a base substance having a hydroxyapatite coated on the base substance, and a zinc oxide fixed to the coating layer of the hydroxyapatite, wherein the zinc oxide is from about 15% to about 25% by weight of the sebum solidifying powder; from about 1% to about 10% of an inorganic oil absorbing powder having an oil absorbency of at least about 200 ml/100 g wherein the weight ratio of the sebum solidifying powder to the inorganic oil absorbing powder is from about 1:1.5 to about 20:1; and a suitable carrier.

The invention relates to a bracket material used for an osseous tissue project, and a preparation method thereof. Firstly, the bracket of a type I collagen is extracted from a small fresh pigskin by a mature extracting technique. Then, the bracket is further expanded in a Tris cushion liquid, the pH of which is equal to 8.8 to obtain a natural porous collagen bracket by the treatments of freezing and drying. The bracket is respectively and repeatedly mineralized in a CaCl2 liquid and in (NH4)2HPO4 liquid or mineralized in simulated body fluid for a long period to lead the weakly crystallized HA to be uniformly settled into the collagen bracket; and then a pigskin collagen-hydroxyapatite ossein is obtained by the treatments of freezing and drying to replace the natural bracket material. The invention not only maintains the natural bracket structure of the collagen in an organism, but also has the advantages of low material cost, simple devices, short period and easy operation. The obtained compound bracket material used for the pigskin collagen-hydroxyapatite osseous tissue project has the characteristics of high intensity, large toughness, non-antigenicity, higher biological activity as well as degradation and releasing control.

The invention discloses a method for preparing a high-strength double-network hydrogel stent by virtue of 3D printing. The method comprises the following steps of adding a polymer monomer N, N-dimethyl acrylamide, an initiator, a crosslinking agent and sodium alginate (SA) into deionized water to form a solution and adding inorganic powder hydroxyapatite to obtain a sol; controlling and extruding the sol by a robot dispenser, and carrying out 3D printing molding to obtain a sol stent; placing the sol stent under ultraviolet light so that the monomer in the stent is subjected to photopolymerization and chemical cross-linking reaction to form a layer of chemically cross-linked network pre-molded hydrogel stent; immersing the pre-molded hydrogel stent into a CaCl2 aqueous solution so that SA in the stent is subjected to physical crosslinking to form a second layer of physically cross-linked network so as to obtain the hydrogel stent having physically and chemically cross-linked double-network. The hydrogel stent prepared by the method has higher mechanical strength and fine internal structure, and the three-dimensional morphology of the stent can be conveniently regulated and controlled to adapt to the complex application requirements of tissue engineering materials.

The invention discloses a method for preparing a hydroxyapatite/nano silver antibacterial composite coating through pulse electrochemical deposition, which comprises: using a calcium salt, phosphate, silver nitrate and a proper amount of coordination agent to prepare electrolyte with certain concentration and pH value, and performing electrodeposition in a electrolytic cell provided with a three-electrode system; taking a saturated calomel electrode as a reference electrode, a platinum sheet as a counter electrode and biological medical metal to be coated as a working electrode, wherein the pulse high electric potential is 0 volt, the pulse low electric potential is -2.0 volts, the pulse width is 100 seconds, and the deposition time is 2 hours; and depositing compositions in the coating on a base material in a mode of ions, uniformly dispersing nano silver generated during deposition in the composite coating, and finally preparing the hydroxyapatite/nano silver antibacterial compositecoating.

This invention relates to the purification of monoclonal antibodies from mammalian cell culture fluid utilizing sequential, orthogonal chromatography and filtration techniques resulting in material of high purity and quality that is suitable for human administration. The method involves capturing an IgG product using immobilized protein A affinity chromatography, followed by at least one ion exchange technique prior to adsorbing the IgG to hydroxyapatite and selectively eluting the product in a single isocratic step to achieve purification from impurities and simultaneously reducing multiple types of impurities including but not limited to IgG aggregates, residual protein A, non-IgG proteins, host cell proteins, viral particles, and DNA

The invention discloses a preparation method of materials which are used for bone plates, bone nails and bone blocks, including the following steps: biomedical fiber, hydroxyapatite, polylactic acid and compatibilizer are arranged at a twin-screw extruder or a torque rheometer for melt blending; or the polylactic acid and the hydroxyapatite which is grafted by using the polylactic acid macromonomer are dissolved in chloroform, the biomedical fiber is added for even dispersion, and the thin film can be obtained by vacuum drying after the volatilization of the chloroform; or the polylactic acid and the biomedical fiber are woven into mesh structure, then the mixed solution of hydroxyapatite powder which is grafted by using the polylactic acid macromonomer and the polylactic acid is added, and the vacuum drying is carried out after the volatilization of the solvent; finally, the materials which are obtained by the method are done with the pressing forming on a flat sulphuration machine or done with the injection forming by using a precise injection machine. The preparation method of the materials which are used for the bone plates, bone nails and bone blocks of the invention has strong practicality, easy industrial production and can significantly improve the mechanical properties of the bone repair materials.

A method for purifying recombinant Factor VII (rFVII) or recombinant activated Factor VII (rFVIIa), comprising subjecting the rFVII or rFVIIa to liquid chromatography on a hydroxyapatite (HAP) column.

The invention belongs to the technical field of membrane and relates to a photocatalytic composite ceramic separation membrane using porous ceramic membrane as a carrier, a method for preparing the same and application of the separation membrane. The method is characterized in that a porous ceramic membrane substrate is used as the carrier to prepare hydroxyapatite sol and argent-titania composite sol through sol-gel technology; and a carrier membrane is subjected to secondary sol-gel dipping, drying and roasting sequentially to obtain the argent-carried titania/hydroxyapatite photocatalytic composite ceramic separation membrane with aperture of between 100 and 1,900 nm and porosity of between 20 and 55 percent. The photocatalytic composite ceramic separation membrane has biological adsorption and high photocatalytic activity and membrane permeability, improves separation of the composite membrane, photocatalytic degradation and sterilization, has remarkable effects of decontamination and sterilization, reduces the loss of porosity in the process of membrane preparation, has a simple preparation and application process, is easy for large-scale industrial production, integrates three units of membrane separation, photocatalytic degradation and sterilization and reduces investment and occupied area.

The invention discloses an artificial articular cartilage material, which relates to the field of chemical modification of hydrogel soft materials. Polyacrylamide-sodium alginate hydrogel is modified with graphene oxide and hydroxyapatite, and PAM-ALG-GO-HA composite hydrogel is prepared by a free radical polymerization reaction. The preparation method comprises the following steps: gradually adding needle-like nano HA particles into a GO solution which is uniformly dispersed in advance to form a mixed aqueous solution, adding an acrylamide monomer, an ALG monomer and related reactants for synthesizing PAM-ALG hydrogel, and performing the free radical polymerization reaction to prepare the PAM-ALG-GO-HA composite hydrogel. According to the artificial articular cartilage material disclosed by the invention, chemical modification is performed on the PAM-ALG hydrogel by fully using the two-dimensional structure of a GO nano chip and the functional groups on the surface and the excellent biological activity of HA, the mechanical property and biological activity of the PAM-ALG hydrogel are effectively improved, the application range of the PAM-ALG hydrogel is expanded, and the artificial articular cartilage material has clear scientific significance and a huge application value.

The present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as Na₂O—Ag₂O—SrO—CaO—MgO—ZnO—P₂O₅—SiO₂—Bi₂O₃—B₂O₃—CaF₂, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity. The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800° C. without devitrification, resulting in bioglass compacts with high flexural strength (˜85 MPa). The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity.