189 results about "Biocompatible material" patented technology

The present disclosure includes fixation devices, such as an orthopedic screw or implant, that comprises one or more porous elements or fenestrations to aid in osteo-integration of the fixation device. The fixation device may be additively manufactured using biocompatible materials such that the solid and porous aspects of the screw are fused together into a single construct. In yet another aspect, the fixation device comprises at least a portion or section incorporating a porous structure, which enables bony ingrowth through the porous section / portion of the screw, and thereby facilitates biocompatibility and improve mechanical characteristics. Methods for using the fixation device are also described herein.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

The present disclosure is directed to ablative devices comprising biocompatible materials in the form of a mesh to provide porosity to allow for the conveyance of conductive fluid to target tissue to be ablated. The mesh also increases the durability of the biocompatible material, reducing the amount of biocompatible material needed for both reusable devices and disposable ablative devices, such as ablative forceps and ablative probes.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

The invention relates to the technical field of periosteal repair, and particularly discloses a suture anchor for periosteal cartilage defect repair and a using method thereof.The suture anchor comprises at least two anchor bodies, the head of each anchor body is a pointed cone part, and a suture blind hole is formed in the tail of each anchor body; at least one group of threading rods which are arranged at intervals with the bottoms of the threading blind holes are arranged in the threading blind holes; the at least one tail line penetrates through the threading blind hole of the anchor main body; and the anchor main body and the tail line are made of biocompatible materials. After the tail line is tightened, irreversible fixation is achieved through an automatic locking structure, postoperative tail line loosening or periosteum displacement is avoided, and the cartilage regeneration effect is improved.

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: -a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, -one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

An apparatus includes an electrically conductive housing configured to be implanted beneath a skin portion of a recipient's body. The apparatus further includes a transducer on or within the housing. The transducer is configured to receive and / or to generate vibrations. The apparatus further includes an electrically insulative and biocompatible material overlaying the housing. The material is configured to electrically insulate the housing and the transducer from the recipient's body. The apparatus further includes at least one vibration conduit configured to be in contact with the recipient's body and to transfer the vibrations between the recipient's body and the transducer. The at least one vibration conduit includes a first portion covered by the material and a second portion not covered by the material.

An implantable marker for marking an intracorporeal tissue region of an animal or human, including at least one strand produced from biocompatible material and which has a three-dimensional shape impressed during a shaping process. The strand adopts the three-dimensional shape after cessation of an external mechanical constraint that forced the strand to adopt a compacted three-dimensional shape. The three-dimensional shape impressed upon the strand comprises at least two fixed strand eyelets with each eyelet being formed by at least one helical winding of the strand and having at least one of shape and relative spatial position being different in the compacted three-dimensional shape forced upon them by the external mechanical constraint and the three-dimensional shape adopted after cessation of the mechanical constraint.

To provide a composition containing at least one or more polymers capable of forming hydrogel, as well as methods of manufacturing and using the hydrogel.SOLUTION: For example, a composition can include one or more hydrogel-forming polymers having an intrinsic viscosity [η] (e.g., as measured by an Ubbelohde viscometer) of at least 3 dL / g in the composition. A concentration CT of the hydrogel-forming polymer in the composition can be at most about 5 mg / ml. More specifically, the present disclosure provides compositions that include polymers (e.g., biocompatible polymers) capable of forming soft hydrogels, and methods of making and using the same.SELECTED DRAWING: None

A nanoparticle vaccine composition includes a shell including one or more amphiphilic molecules and one or more hapten molecules, where at least one amphiphilic molecule is conjugated to the hapten molecule, and a substantially hydrophobic core including an immunogenic protein, a vaccine adjuvant, one or more inert biocompatible materials, or a combination of two or more thereof, where the core is encapsulated in the shell to form a nanoparticle.

The invention relates to an antibacterial contact lens silicon hydrogel composite material and a preparation method thereof, and belongs to the technical field of silicon hydrogel materials, and the preparation method comprises the following steps: combining a natural compound with a biocompatible material to obtain a composite material; combining the composite material with a zwitterionic polymer to obtain an antibacterial reinforced material; the preparation method comprises the following steps: mixing a siloxane oligomer, an antibacterial reinforcing material, a hydrophilic monomer, a small molecular silicon monomer, a thermal initiator and a cross-linking agent, and carrying out polymerization reaction to obtain the antibacterial contact lens silicon hydrogel composite material, according to the technical scheme, the natural compound is combined with the biocompatible material, so that the antibacterial property and the stability of the silicon hydrogel composite material can be effectively improved; the composite material is combined with the zwitterionic polymer, so that the hydrophilicity and moisture retention of the silicon hydrogel composite material can be improved, the antibacterial performance of the silicon hydrogel composite material is further improved, and the comprehensive performance of the antibacterial contact lens silicon hydrogel composite material is generally improved.

Wound dressings and methods for treating a wound are provided. The wound dressing can have an environment-facing side that includes a biocompatible material having a polymer crosslinked with an antimicrobial effective amount of a NO-donor and a wound-facing side including a biocompatible resinous matrix and an antifibrinolytic agent. The wound dressing can promote fibrin formation and rapid platelet aggregation, and has antimicrobial properties. The dressing can be applied directly to the wound.

The invention discloses a kirschner wire sleeve device for muscle layer expansion, which relates to the technical field of orthopedic surgery and comprises a kirschner wire, an expansion sleeve, a protective layer and a traction rod. The expansion sleeve is composed of a support and an expansion layer, a guide ring is arranged in the middle of the support, symmetrical connecting frames are arranged on the outer side of the guide ring, the expansion layer is sleeved outside the guide ring, and one end close to a skeleton is of an involute pipeline structure. After the Kirschner wire fixes the bone, the guide ring slides towards the bone along the Kirschner wire, the involute pipeline structure of the expansion layer enters the space between the Kirschner wire and the muscle layer, and the muscle layer is pushed away outwards to form an operation space. The protective layer can reduce direct friction between the muscle layer and the expansion layer, and the lubricant arranged in the protective layer can assist operation; the traction rod can stably control the expansion layer to be opened. The device is made of a biocompatible material and is provided with a buffer structure, the operation space can be flexibly adjusted, the operation safety, adaptability and efficiency are effectively improved, and the use pain point of a traditional kirschner wire sleeve device is solved.

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

The present invention relates to a photocurable composition for manufacturing a patient-customized biliary stent by using a 3D printer, and a patient-customized biliary stent using same. A conventional photocurable composition for a 3D printer is hard and cannot be used as a biliary stent, but the photocurable composition for a 3D printer, of the present invention, can exhibit physical properties at levels enabling use as a biliary stent, and can be manufactured, using biocompatible material properties, as a stent customized for a patient requiring a biliary stent procedure.

A photocurable formulation usable in additive manufacturing a three-dimensional object is disclosed. The formulation features, in at least a portion thereof, a biological or a biocompatible material, the photocurable formulation comprising a photoinitiator, a photocurable biological or biocompatible material, and a carrier, the formulation further comprising at least two photocurable polymeric materials. Implants comprising same are also disclosed.

Implants including stitching patterns that overlap to produce a corner-locked stitch pattern. An implant may include a substrate including a biocompatible material a reinforcing mesh sewn into the substrate. The reinforcing mesh may include a corner-stitch pattern that includes a first lock-stitch pattern and a second lock-stitch pattern. The first lock-stitch pattern may include a first upper thread and a first lower thread that interlace at a first thread interlace point. The second lock-stitch pattern may include a second upper thread and a second lower thread that interlace at a second thread interlace point. The second lock-stitch pattern may overlap the first lock-stitch pattern such that the second upper thread and the second lower thread envelop the first upper thread and the first lower thread adjacent to the first thread interlace point and the second thread interlace point.

A microelectrode probe for implantation in soft tissue, comprising a sheath of flexible polymeric material divided by a wall into a distal and a proximal compartment, said distal and proximal compartments being filled with a matrix of biocompatible material dissolvable or degradable in aqueous body fluids, and comprising a centrally disposed electrically conductive core passing through the wall and attached to it. The core is insulated at its proximal portion, from which it extends to a holder for attachment to tissue other than said soft tissue. The sheath and the core extending distally from said holder are embedded in a kindred additional matrix. The invention also discloses a method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array and a method for the manufacture of the array.

The invention discloses a preparation method of anti-adhesion particles. The invention belongs to the technical field of biomedical materials. The raw materials used in the invention are all biocompatible materials, and inflammatory reaction and toxic residue are avoided through a natural cross-linking agent and non-toxic solvent system; through the synergistic effect and cross-linking treatment of the carboxymethyl cellulose, the chitosan and the polylactic acid, the particles can maintain the anti-adhesion effect for 7-14 days in vivo, and the key adhesion prevention period after soft tissue and urinary surgery is covered; the particles have flexibility, antibacterial property and urine corrosion resistance, can be used for preventing adhesion of soft tissue postoperative wounds, and can also be used for preventing adhesion of urinary surgical operation sites and modifying instrument surfaces; the low-temperature spray drying and gamma-ray sterilization process ensures the activity of the raw materials and the sterility of the product, the process parameters are easy to control, the method is suitable for industrial production, and the production cost is reduced compared with the existing like products.

The compositions described herein are useful in medical procedures, such as separating tissue layers, such as submucosal tissue layers, for resection. In some examples, the composition may include a pharmaceutically acceptable carrier fluid, and one or more biocompatible materials at least partially or fully dissolved or suspended in the pharmaceutically acceptable carrier fluid. The one or more biocompatible materials may be selected from the group consisting of polymers, phospholipids, nanoclays, or combinations thereof. Advantageously, the composition can be formulated as a solution, emulsion, gel or suspension that can be injected into tissue.

A system with reusable components and methods are disclosed for culturing, forming, perfusing, and maintaining a perfusible-tissue construct. The system uses a production container comprising a floor, a wall extending from the floor, wherein the floor and wall define a production reservoir, a formation section defined in the floor, wherein the formation section comprises at least one well, and a grip extending outwardly from the formation section; wherein the production container is made of a biocompatible material that remains stable when autoclaved.

The present patent application relates to nanoparticles for the delivery and targeting of a non-tumour-specific antigen in cancer cells, comprising a matrix support based on a biocompatible material, the non-tumour-specific antigen, and an adjuvant, for use in recalling, in cancer patients who have a specific immunity for the non-tumour- specific antigen pre-existing to the tumour pathology, the immune response specific to the non-tumour-specific antigen against the cancer cells. A further object of the application is anti-tumour pharmaceutical formulations comprising nanoparticles and kits comprising the aforementioned anti-tumour pharmaceutical formulations in combination with traditional anti-tumour vaccines.

Breathing mask for use with CPAP or ventilators, including: • an integrated nasal applicator with two conically shaped pads that can be inserted into the nostrils, • a central connecting element made of flexible, biocompatible material, • wherein the nasal cushions are connected to each other by a bridge to prevent complete penetration into the nose, • and wherein the mask has a front port for a breathing tube and a rear port for a mouthpiece.

An object of the present invention is to provide a fusion protein that can be easily used to purify and grow target cells, and to provide a biocompatible material such as chitin or chitosan that can be easily used as a cell culture surface. The present invention provides a fusion protein comprising a region consisting of at least one peptide capable of adhering to chitins, and a region consisting of at least one peptide or protein capable of adhering to cells.

To simply utilize a biocompatible material such as chitin or chitosan as a cell culture surface and to provide a fusion protein simply utilizable for purification and proliferation of an objective cell.SOLUTION: The present invention provides a fusion protein comprising a region consisting of at least one peptide capable of adhering to chitins and a region consisting of at least one peptide or protein capable of adhering to cells.SELECTED DRAWING: Figure 1

A pain relief apparatus includes a first pod and an attachment mechanism. The first pod is formed from a first biocompatible material and has a space defined therein for retaining a fluid. The first pod is configured to be selectively positioned within a mouth of a patient. The first biocompatible material is semi-compliant. The attachment mechanism is operably coupled at a first end of the first pod and made from a second biocompatible material. The attachment mechanism is configured to selectively retain the first pod within the mouth of the patient. The fluid is only partially freezable within the first pod allowing the first pod to remain semi-compliant to facilitate positioning within the mouth.

The invention discloses a magnetic positioning accurate temperature control ablation catheter device for atrial fibrillation radiofrequency ablation, and relates to the technical field of atrial fibrillation radiofrequency ablation. According to the catheter device, the magnetic sensing assembly is arranged, magnetoresistive sensors and a central miniature permanent magnet which are evenly distributed on the circumference are adopted, three-dimensional accurate positioning is achieved in combination with an in-vitro magnetic field, positioning deviation caused by cardiac pulsation is reduced or eliminated, a plurality of miniature thermocouples cover the hemispherical end, and the annular perfusion hole channel, full-dimensional temperature control and uniform cooling are matched; five cavities of the main body section independently avoid winding, a nickel-titanium spring and a double-layer woven wire of the bendable section give consideration to bendability and stability, a core component is made of a biocompatible material, thrombus and allergy risks are reduced, and the device is adaptive to existing equipment and is convenient and durable to operate and control.

A spinal implant is disclosed for engagement to portions of a spinal segment after a laminectomy procedure. The spinal implant includes a first member and a second member in orthogonal relation relative to the first member such that the spinal implant generally defines a t-shape configuration. The spinal implant is formed using biocompatible materials to safely adapt to the surgical area. The spinal implant may include hooks or apertures for engaging with portions of bodily tissue. The spinal implant may be engaged to other spinal implants along the spine using one or more arms of an interconnecting arrangement.

A medical implant with a structure made of at least one biocompatible material, converted from a first spatially compact state into a second spatially deployed and flexible deformable state, has a modulus of elasticity corresponding to the wall of a blood vessel in an order of magnitude between 105 Nm2 and 107 N m2, has at least one region with an acoustic impedance of more than 1.63·106 kg / m2 s, and in the second state has an effective operating surface that is flexibly deformable and at least partially reflects ultrasonic waves. Ultrasonic waves are generated by a sonographic device and which strike an effective operating surface of the intracorporeally applied medical implant and are partially reflected for detecting changes in the spatial distance between the operating surface and the sonography device.