112 results about "Biocompatible material" patented technology

The present disclosure is directed to ablative devices comprising biocompatible materials in the form of a mesh to provide porosity to allow for the conveyance of conductive fluid to target tissue to be ablated. The mesh also increases the durability of the biocompatible material, reducing the amount of biocompatible material needed for both reusable devices and disposable ablative devices, such as ablative forceps and ablative probes.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: -a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, -one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

An apparatus includes an electrically conductive housing configured to be implanted beneath a skin portion of a recipient's body. The apparatus further includes a transducer on or within the housing. The transducer is configured to receive and / or to generate vibrations. The apparatus further includes an electrically insulative and biocompatible material overlaying the housing. The material is configured to electrically insulate the housing and the transducer from the recipient's body. The apparatus further includes at least one vibration conduit configured to be in contact with the recipient's body and to transfer the vibrations between the recipient's body and the transducer. The at least one vibration conduit includes a first portion covered by the material and a second portion not covered by the material.

To provide a composition containing at least one or more polymers capable of forming hydrogel, as well as methods of manufacturing and using the hydrogel.SOLUTION: For example, a composition can include one or more hydrogel-forming polymers having an intrinsic viscosity [η] (e.g., as measured by an Ubbelohde viscometer) of at least 3 dL / g in the composition. A concentration CT of the hydrogel-forming polymer in the composition can be at most about 5 mg / ml. More specifically, the present disclosure provides compositions that include polymers (e.g., biocompatible polymers) capable of forming soft hydrogels, and methods of making and using the same.SELECTED DRAWING: None

A nanoparticle vaccine composition includes a shell including one or more amphiphilic molecules and one or more hapten molecules, where at least one amphiphilic molecule is conjugated to the hapten molecule, and a substantially hydrophobic core including an immunogenic protein, a vaccine adjuvant, one or more inert biocompatible materials, or a combination of two or more thereof, where the core is encapsulated in the shell to form a nanoparticle.

Wound dressings and methods for treating a wound are provided. The wound dressing can have an environment-facing side that includes a biocompatible material having a polymer crosslinked with an antimicrobial effective amount of a NO-donor and a wound-facing side including a biocompatible resinous matrix and an antifibrinolytic agent. The wound dressing can promote fibrin formation and rapid platelet aggregation, and has antimicrobial properties. The dressing can be applied directly to the wound.

The present invention relates to a photocurable composition for manufacturing a patient-customized biliary stent by using a 3D printer, and a patient-customized biliary stent using same. A conventional photocurable composition for a 3D printer is hard and cannot be used as a biliary stent, but the photocurable composition for a 3D printer, of the present invention, can exhibit physical properties at levels enabling use as a biliary stent, and can be manufactured, using biocompatible material properties, as a stent customized for a patient requiring a biliary stent procedure.

A photocurable formulation usable in additive manufacturing a three-dimensional object is disclosed. The formulation features, in at least a portion thereof, a biological or a biocompatible material, the photocurable formulation comprising a photoinitiator, a photocurable biological or biocompatible material, and a carrier, the formulation further comprising at least two photocurable polymeric materials. Implants comprising same are also disclosed.

Implants including stitching patterns that overlap to produce a corner-locked stitch pattern. An implant may include a substrate including a biocompatible material a reinforcing mesh sewn into the substrate. The reinforcing mesh may include a corner-stitch pattern that includes a first lock-stitch pattern and a second lock-stitch pattern. The first lock-stitch pattern may include a first upper thread and a first lower thread that interlace at a first thread interlace point. The second lock-stitch pattern may include a second upper thread and a second lower thread that interlace at a second thread interlace point. The second lock-stitch pattern may overlap the first lock-stitch pattern such that the second upper thread and the second lower thread envelop the first upper thread and the first lower thread adjacent to the first thread interlace point and the second thread interlace point.

A microelectrode probe for implantation in soft tissue, comprising a sheath of flexible polymeric material divided by a wall into a distal and a proximal compartment, said distal and proximal compartments being filled with a matrix of biocompatible material dissolvable or degradable in aqueous body fluids, and comprising a centrally disposed electrically conductive core passing through the wall and attached to it. The core is insulated at its proximal portion, from which it extends to a holder for attachment to tissue other than said soft tissue. The sheath and the core extending distally from said holder are embedded in a kindred additional matrix. The invention also discloses a method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array and a method for the manufacture of the array.

The invention discloses a preparation method of anti-adhesion particles. The invention belongs to the technical field of biomedical materials. The raw materials used in the invention are all biocompatible materials, and inflammatory reaction and toxic residue are avoided through a natural cross-linking agent and non-toxic solvent system; through the synergistic effect and cross-linking treatment of the carboxymethyl cellulose, the chitosan and the polylactic acid, the particles can maintain the anti-adhesion effect for 7-14 days in vivo, and the key adhesion prevention period after soft tissue and urinary surgery is covered; the particles have flexibility, antibacterial property and urine corrosion resistance, can be used for preventing adhesion of soft tissue postoperative wounds, and can also be used for preventing adhesion of urinary surgical operation sites and modifying instrument surfaces; the low-temperature spray drying and gamma-ray sterilization process ensures the activity of the raw materials and the sterility of the product, the process parameters are easy to control, the method is suitable for industrial production, and the production cost is reduced compared with the existing like products.

The present patent application relates to nanoparticles for the delivery and targeting of a non-tumour-specific antigen in cancer cells, comprising a matrix support based on a biocompatible material, the non-tumour-specific antigen, and an adjuvant, for use in recalling, in cancer patients who have a specific immunity for the non-tumour- specific antigen pre-existing to the tumour pathology, the immune response specific to the non-tumour-specific antigen against the cancer cells. A further object of the application is anti-tumour pharmaceutical formulations comprising nanoparticles and kits comprising the aforementioned anti-tumour pharmaceutical formulations in combination with traditional anti-tumour vaccines.

To simply utilize a biocompatible material such as chitin or chitosan as a cell culture surface and to provide a fusion protein simply utilizable for purification and proliferation of an objective cell.SOLUTION: The present invention provides a fusion protein comprising a region consisting of at least one peptide capable of adhering to chitins and a region consisting of at least one peptide or protein capable of adhering to cells.SELECTED DRAWING: Figure 1

A pain relief apparatus includes a first pod and an attachment mechanism. The first pod is formed from a first biocompatible material and has a space defined therein for retaining a fluid. The first pod is configured to be selectively positioned within a mouth of a patient. The first biocompatible material is semi-compliant. The attachment mechanism is operably coupled at a first end of the first pod and made from a second biocompatible material. The attachment mechanism is configured to selectively retain the first pod within the mouth of the patient. The fluid is only partially freezable within the first pod allowing the first pod to remain semi-compliant to facilitate positioning within the mouth.

The invention discloses a magnetic positioning accurate temperature control ablation catheter device for atrial fibrillation radiofrequency ablation, and relates to the technical field of atrial fibrillation radiofrequency ablation. According to the catheter device, the magnetic sensing assembly is arranged, magnetoresistive sensors and a central miniature permanent magnet which are evenly distributed on the circumference are adopted, three-dimensional accurate positioning is achieved in combination with an in-vitro magnetic field, positioning deviation caused by cardiac pulsation is reduced or eliminated, a plurality of miniature thermocouples cover the hemispherical end, and the annular perfusion hole channel, full-dimensional temperature control and uniform cooling are matched; five cavities of the main body section independently avoid winding, a nickel-titanium spring and a double-layer woven wire of the bendable section give consideration to bendability and stability, a core component is made of a biocompatible material, thrombus and allergy risks are reduced, and the device is adaptive to existing equipment and is convenient and durable to operate and control.

A film for integrating with tissue and promoting at least one of endothelial cell adhesion, migration, proliferation, ingrowth, infiltration, angiogenesis, sprouting angiogenesis, neovascularization, and vascularization includes a plurality of fibers arranged in an overlapping configuration to form a porous, thin film with an average pore size of at least 0.01 μm2 and less than 60 μm2. The plurality of fibers has an average diameter of at least 10 nm and less than 1,000 nm. Each of the plurality of fibers have an aspect ratio of length to width of at least 10, and each of the plurality of fibers is a biocompatible material.

The present invention introduces a groundbreaking solution in the field of male contraception-a reversible male birth control implant device. The device offers enhanced flexibility in family planning by controlling the amount of sperm ejaculated. It consists of a tubular component surgically inserted into each severed vas deferens, with a wireless receiver attached. The wireless receiver receives external wireless signals and enables the device to switch between a state that permits the flow of sperm and a state that impedes it. The device also features an outlet for the safe elimination of obstructed sperm. The use of biocompatible materials and compatibility with medical imaging devices, such as MRI, ensures safety and usability. This innovative device empowers individuals with convenient and discreet control over their fertility, revolutionizing male contraception and opening new possibilities in reproductive health.

The application discloses a kind of biocompatible materials and preparation method for bionic porous intervertebral fusion cage, belong to intervertebral fusion cage material technical field.A kind of biocompatible materials for bionic porous intervertebral fusion cage, by weight parts includes the following components: polyether ether ketone 65-80 parts, modified functional filler 15-25 parts, hydroxyapatite 8-12 parts, flow modifier 0.5-1 part;The modified functional filler is graphene oxide coated modified barium titanate functional filler.By introducing surface conductive modified nano piezoelectric ceramic particles, realize the effective conversion and transmission of mechanical stimulation to bioelectric signal, this microstructure design makes the insulating polyether ether ketone matrix possess the electric activity of simulating natural bone stress-electric signal response mechanism, so as to be favorable to activate osteoblast activity and promote bone integration of implant interface.

The present disclosure is directed to methods for fabricating cellulose-based microneedles with exceptional wicking properties which can be used for rapid extraction of dermal interstitial fluid (ISF). Microneedle arrays are fabricated through a combination of compression molding and laser etching, utilizing microcrystalline cellulose, a biocompatible material with excellent wicking properties. These microneedles are mechanically robust and can autonomously extract fluid from the skin without the need for external instruments. As such, they can be directly integrated with paper-based lateral flow immunoassays for point-of-care disease detection.

Modular organ-on-chip system comprising: - a platform with external dimensions according to a microtiter plate standard, - a plurality of modular cell culture components for holding biological tissues, - wherein the platform and / or modules are manufactured by 3D printing from biocompatible material and can be fluidically connected to each other.

The invention discloses a facial skin lifting and gathering device and method based on adsorptive anchor points, and belongs to the technical field of beauty and skin care. According to the device, the flexible anchor point unit with the micro-adsorption structure is arranged on the surface of the facial skin, and the loose or drooping skin area is gently lifted and directionally gathered by utilizing the physical adsorption principle, so that the facial contour line is improved, and the skin compactness is improved. The anchor point units are made of biocompatible materials and can be distributed in a manner of being attached to the face curve, dynamic tension control is achieved through adjustable connecting pieces, and the anchor point units adapt to different face areas and individual differences. The using method comprises the steps of face cleaning, anchor point positioning, lifting force adjusting, fixing and the like, operation is easy and convenient, invasive means are not needed, and the facial mask is suitable for daily skin care scenes. The face rejuvenation effect under the non-medical means is achieved, and the face rejuvenation device has the advantages of being safe, non-invasive and instant and visible and can be widely applied to family beauty nursing and beauty institution service.

The embodiment of the invention discloses a bone soft tissue tumor repair prosthesis printing method based on a multi-agent decision-making system. The method comprises the following steps: generating tumor knowledge map information according to preset tumor grade screening information, preset tumor grading standard information, acquired tumor-related material information and tumor-related material information; performing change processing on the initialized preset tumor decision intelligent agents to obtain a tumor decision intelligent agent group; generating task processing distribution information according to preset tumor record information and the tumor decision agent group; according to the tumor decision intelligent agent group, the task processing distribution information and the tumor knowledge graph information, prosthesis printing reference information is generated; according to the prosthesis printing reference information, generating a tumor material reconstruction image; and according to the tumor material reconstruction image, controlling a printing device to print a tumor repair prosthesis. According to the implementation mode, the accuracy of the generated prosthesis printing reference information can be improved, and waste of biocompatible materials for 3D printing is reduced.

This invention discloses a localized long-acting anesthetic sustained-release gel and its preparation method, belonging to the field of medical anesthetic sustained-release materials. In the preparation process, 100-300nm hollow SiO2 particles are first modified with PEG-PLA, and then emulsified using microfluidics to obtain a monodisperse suspension. Next, chitosan is dissolved, and anesthetic drugs such as lidocaine are added. The suspension is then added dropwise, and the carboxyl groups are activated using EDC-NHS, followed by a low-temperature reaction at 4°C to form a gel. This gel prolongs the drug effect through the "double drug barrier layer" of the modified hollow SiO2 particles, and its morphological stability is ensured within 24 hours by particle support. All materials are medical-grade biocompatible materials, and the microfluidic process solves particle aggregation, making it suitable for surface anesthesia.

The invention provides a bent fat rubbing needle, which is particularly suitable for fat release and suction operation of a region with physiological curvature of a slender bag. The fat rubbing needle body is in the preset bent shape, the bending angle ranges from 10 degrees to 60 degrees, the fat rubbing needle body better fits the natural radian of the neck and the natural radian of the shoulder, and operation smoothness and the comfort level of a patient are improved. A plurality of micropores are formed in the side wall of the needle body and are connected with a negative pressure device to assist in releasing and sucking adipose tissues, so that the operation efficiency is improved. The front end blunt end structure can effectively prevent nerve and blood vessel from being damaged by puncture, and safety is enhanced. The fat rubbing needle is made of medical stainless steel or biocompatible materials, and different use requirements are met. The matched bent liposuction needle is matched with the angle of the liposuction needle to cooperatively complete fat removal. The separating grooves and the clamping grooves are formed in the instrument box, various tools are stored in a classified mode, and the taking efficiency in an operation is improved. The needle is not only suitable for the treatment of the drastic bag, but also can be expanded to be applied to other plastic surgeries needing to be operated along the body curve, and has a wide application prospect.

This invention belongs to the field of biomedical materials technology, and discloses a one-step chitosan-grafted iohexol self-illuminating microsphere, its preparation method, and its applications. The microsphere uses chitosan, a natural biocompatible material, as the carrier framework, iohexol as the self-illuminating functional component, and genipin, a natural extract, as the cross-linking agent. A one-step grafting and cross-linking curing process is used to form self-illuminating microspheres with uniform particle size and stable structure. These microspheres exhibit clear imaging under X-rays and also possess good biocompatibility, biodegradability, and sustained-release properties, making them widely applicable in medical fields such as tumor embolization therapy and tissue engineering tracing, achieving integrated diagnosis and treatment. The preparation process of this invention is simplified, requiring no multi-step reactions, with mild control conditions, and is easy for industrial production, solving the problems of complex preparation, poor biocompatibility, and imbalance between imaging and biological properties in traditional self-illuminating materials.

The invention discloses a noninvasive tear analysis device and evaluation system for comprehensive evaluation of ocular surface health, the device has an external form and a corneal contact lens form, and the device comprises a substrate, a capillary drainage structure, a tear component sensing unit, a physical parameter sensing unit and a packaging piece; the capillary drainage structure is arranged on the substrate and is used for collecting and guiding tears from the ocular surface through capillary action; the tear component sensing unit is arranged on the substrate and is in fluid communication with the capillary drainage structure; the physical parameter sensing unit is arranged on the substrate; the packaging piece is connected with the substrate and is used for packaging a structure on the substrate; through the external and corneal contact lens type structural design, noninvasive intervention on the ocular surface is achieved, independent drainage of tears is achieved through the capillary action, external active suction or physical scraping is avoided, and the sampling reliability is guaranteed while the wearing safety and comfort are guaranteed to the maximum extent by combining with a biocompatible material.

The invention relates to the technical field of traditional Chinese medicine gels. The invention provides gel for treating gynecological inflammation and a preparation method thereof. The gel is prepared from the following raw materials in parts by weight: 75 to 85 parts of traditional Chinese medicine extracting solution, 6 to 10 parts of glycerol, 0.2 to 0.4 part of sodium carboxymethyl cellulose, 0.3 to 0.5 part of carbomer and 3 to 4 parts of sodium alginate. The traditional Chinese medicine gel disclosed by the invention takes radix sophorae flavescentis, fructus cnidii, dandelion, scutellaria baicalensis and the like as core components, an efficient and mild gynecological inflammation treatment agent is developed, core traditional Chinese medicines are fused, and a biocompatible material is combined, so that quick effect taking and no side effect are ensured, and a better choice is provided for a patient.

Wound dressings and methods for treating a wound are provided. The wound dressing can have an environment-facing side that includes a biocompatible material having a polymer crosslinked with an antimicrobial effective amount of a NO-donor and a woundfacing side including a biocompatible resinous matrix and an antifibrinolytic agent. The wound dressing can promote fibrin formation and rapid platelet aggregation, and has antimicrobial properties. The dressing can be applied directly to the wound.