28 results about "Vascular tissue" patented technology

The utility model discloses a closing clip capable of preventing tissue from being torn, and belongs to the field of medical hemostatic clips. The closing clamp capable of preventing the tissue from being torn comprises a first clamping arm and a second clamping arm, the near ends of the first clamping arm and the second clamping arm are connected through a connecting part, and the far end of the first clamping arm and the far end of the second clamping arm are respectively provided with a locking structure which can be buckled and locked together. The clamping faces of the first clamping arm and the second clamping arm are each divided into an anti-skid tooth face and a clamping smooth face in the width direction, and the anti-skid tooth face and the clamping smooth face of the first clamping arm and the anti-skid tooth face and the clamping smooth face of the second clamping arm are arranged in a one-to-one correspondence mode or in a crossed correspondence mode. According to the utility model, the clamping surfaces of the two clamping arms of the closing clamp are divided into the anti-slip tooth surfaces and the clamping smooth surfaces, so that the clamping pressure of the closing clamp on vascular tissues during closing is reduced, unnecessary damage to the tissues in the process of closing the tissues is effectively avoided, and hemostasis failure caused by tearing of the vascular tissues is prevented.

The utility model provides a catheter assembly and an intravascular ultrasonic imaging device. The catheter assembly is used for at least movably collecting ultrasonic echo signals of vascular tissue. The catheter assembly comprises a shell, an ultrasonic transducer, a displacement sensor and a driving part. A containing cavity is formed in the shell. The ultrasonic transducer is arranged in the containing cavity and used for transmitting ultrasonic pulses to the vascular tissue and receiving ultrasonic echo signals formed by reflection of the vascular tissue. The displacement sensor is arranged in the containing cavity and used for obtaining position information in the moving process when the shell moves in the vascular tissue. The two ends of the driving part are connected with the ultrasonic transducer and the displacement sensor correspondingly, and the driving part is used for driving the ultrasonic transducer to rotate in the circumferential direction. Therefore, the structure of the intravascular ultrasonic imaging device is effectively simplified while the signal acquisition effect of the catheter assembly is ensured.

The present disclosure provides a method for evaluating a seedling plant character of a transgenic poplar and use of an overexpressed pagEXPA1 gene in promoting xylem development of the poplar, relating to the technical field of forest wood character determination. The method for evaluating the seedling plant character of the transgenic poplar in the present disclosure includes the following steps: S1. detecting whether or not a foreign gene is integrated into a poplar genome through PCR; S2. detecting the expression level of the foreign gene in the poplar; S3. conducting a microstructural analysis on stem vascular tissues of the transgenic poplar; and S4. separating fibers, ducts, and sieve-tube cells through fiber isolation, and staining the isolated fibers to observe the morphology and structure of the fibers, ducts, and sieve-tube cells.

The invention relates to the technical field of interventional medical treatment, and discloses a magneto-optical positioning assisted catheter wall contact risk monitoring system and method.The method comprises the steps that initial three-dimensional position data and actual magnetic field signals of a catheter are collected, and the initial three-dimensional position data are calibrated based on the actual magnetic field signals and a preset magnetic field reference signal range; a contact force signal of the wall surface of the catheter and the vascular tissue and temperature data in the catheter are collected, and the contact force signal is corrected based on the temperature data and a preset reference temperature interval; acquiring wall surface image data of the front end and the lateral direction of the catheter, extracting image features, and establishing a spatial geometrical relationship between the wall surface of the catheter and vascular tissue; according to the final three-dimensional position data of the catheter and the mapping result of the spatial geometrical relationship, judging the contact risk level of the wall surface of the catheter and the vascular tissue; and outputting warning information and sending a motion compensation control instruction based on the risk level. According to the invention, real-time monitoring and accurate intervention of the contact risk of the wall surface of the catheter can be realized.

A system including an elongate shaft configured to be placed into an access lumen of an access catheter having a side access port that communicates with the access lumen, the shaft including a dilator catheter lumen extending therethrough and a distal portion including a tapered distal tip, the distal portion configured to be passed out of the side access port, a puncture device including an elongate shaft including a distal end configured to penetrate through vascular tissue, a first engagement feature carried by the dilator catheter, and a second engagement feature carried by the puncture device, wherein the second engagement feature is configured to engage the first engagement feature at a first relative longitudinal position between the dilator catheter and the puncture device at which the distal end of the shaft of the puncture device is fully exposed from the dilator catheter and is located at a preconfigured amount of extension out of the dilator catheter lumen.

The invention discloses and provides a multifunctional postoperative monitoring device for anastomosing vascular tissues of limbs, comprising: a base comprising a driving assembly, an adjusting assembly and a control module; the limb rehabilitation device comprises a fixed arm and a movable arm, an inlet is formed in one end of the fixed arm, and the other end of the fixed arm is in sealed connection with one end of the movable arm through a folding cover; the monitoring system is used for monitoring internal parameters of the movable arm; the regulation and control system is used for regulating and controlling internal temperature, humidity and oxygen content of the fixed arm and the movable arm; wherein the driving assembly is used for driving the movable arm to be close to or away from the fixed arm, the adjusting assembly is used for adjusting the angle of the movable arm, and the control module is used for receiving signals of the monitoring system and controlling the regulation and control system to work.

This disclosure provides transabdominal fetal oximetry (TFO) that uses frequency-modulated continuous-wave (FMCW) time-domain near-infrared spectroscopy to measure time-resolved reflectance values of light signals collected from a maternal-fetal multilayer tissue structure. In various embodiments, the disclosed FMCW time-domain near-infrared spectroscopy is configured to function as an optical interferometer that uses two frequency-swept laser sources of different center wavelengths λ1 and λ2 as probe lights to detect optical property in vascular tissues of the maternal-fetal multilayer tissue structure. The FMCW near-infrared spectroscopy is configured to collect light signals returned from the multilayer structure and generate a time-resolved reflectance curve based on the collected light signals.

A three-dimensional periodic minimal curved surface conformal design-based pelvis comprises a pelvis prosthesis body, the pelvis prosthesis body is of a pore structure which is integrally formed through 3D printing and is formed by a plurality of three-dimensional periodic minimal curved surface (TPMS) metamaterial filling units, and the pelvis prosthesis is in a geometric shape symmetrical to a healthy pelvis side. The mounting end of the pelvic prosthesis is tangent to a pelvic defect part, the TPMS metamaterial can realize a complex geometrical shape under micron-level precision and can efficiently adapt to pelvis with different damage degrees, and the TPMS structure has bicontinuous or multi-continuous geometrical characteristics and can provide extremely high surface area and porosity in unit volume, so that the pelvic prosthesis can be applied to the pelvis with different damage degrees. The high surface area of the TPMS microstructure provides sufficient space for adhesion and growth of bone cells, and meanwhile, rapid invasion of vascular tissues and efficient transportation of nutrient substances are promoted through the continuous open pore channel design of the TPMS microstructure. Due to the characteristic, the osseointegration process can be accelerated, and the rehabilitation period of a patient can be remarkably shortened.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

The utility model relates to the technical field of medical apparatus and instruments provides a kind of medical operating forceps, including first forceps body, with the second forceps body of first forceps body cross articulation, and respectively set in the head of the first forceps body and second forceps body two head forceps head, one forceps head is provided with needle body, needle body is locked on forceps head by locking member, to realize the detachable connection between needle body and forceps head, needle body is relative to the circular arc shape of forceps head and is bent upwards clockwise or upwards counterclockwise, needle body has needle head, needle head is set on one free end of needle body.The needle body design of arc structure makes needle body more easily pass through tissue, reduces the damage to surrounding vascular tissue, helps to improve operation accuracy, in addition, the needle body of arc structure is more easily controlled needle body direction and needle angle, improves operation efficiency.

This invention discloses a method for increasing the lignin content in the roots of Lauraceae fruit trees, belonging to the field of plant physiological regulation technology. To increase the lignin content in the roots of Lauraceae fruit trees such as avocado trees, this invention employs the following techniques: application of a lignin-synthetic nutrient-enhancing solution; directional pulsed electric field treatment to enhance the permeability of the fruit tree's epidermal cell membranes; activation of key enzymes in phenylpropanoid metabolism by irradiation with specific wavelengths of ultraviolet light; and synergistic application of mechanical stress technology to stimulate and induce vascular tissue differentiation. By treating the roots of Lauraceae fruit trees, not only can the lignin content in the root system be increased by more than 30%, but the root system's stress resistance and mechanical strength can also be improved by more than 45%, while maintaining normal physiological metabolism of the plant. This provides a new solution for lodging-resistant cultivation and root rot prevention in Lauraceae fruit trees.

Devices, systems, and methods are provided for treating or preventing heart failure or symptoms of heart failure by coordinated disruption of neural activity to one or more target nerves. A device disclosed herein may include a vascular catheter comprising a retractable needle assembly configured to puncture vascular tissue in contact with the catheter, the needle assembly comprising one or more electrodes configured to deliver electrical energy to tissue in contact with one or more electrodes. A method may include treating or preventing heart failure or symptoms of heart failure by inserting the catheter into the vascular tissue of a patient, guiding the catheter toward the greater splanchnic nerve, puncturing the patient's vascular tissue with a retractable needle assembly extending outward from the catheter toward the target nerve, and dissecting the target nerve by delivering stimulating energy to the target nerve using one or more electrodes.

An apparatus includes processor circuitry configured to communicate with an intravascular imaging catheter. The processor circuitry is configured to output a first screen display to a display in communication with the processor circuitry, the first screen display including an intravascular image obtained by the intravascular imaging catheter, wherein the intravascular image includes a vascular lumen and vascular tissue. The processor circuitry is further configured to: receive a single user input on the intravascular image identifying a location within a region of interest; and automatically determine the boundary of the region of interest in response to the single user input, wherein the boundary surrounds the location identified by the single user input. The processor circuitry is further configured to output a second screen display to the display, the second screen display including the intravascular image and the boundary of the region of interest superimposed on the intravascular image.

The invention relates to the field of biomedicine, and discloses a capillary segment extraction method and application thereof. The method comprises a step of digesting rat brain tissues and a step of separating brain microvascular segments. The method provided by the invention is simple to operate, can be directly realized on wild animals, and does not depend on animal endogenous fluorescent labeling. According to the method, the complete vascular tissue can be obtained, meanwhile, the activity of the cells is reserved, the method is the first method capable of separating the complete vascular tree from the brain tissue and then further researching the functions of all the cells on the vascular tissue, and the method has important significance on research of the brain microvascular segment.

The application discloses a transcription factor VTP1 regulation stem vascular development and application in improving rape yield, and belongs to the technical field of plant genetic engineering. The application first finds that after overexpression of VTP1, the rape stem diameter and stem vascular bundle number can be significantly increased, and the single plant yield, thousand kernel weight and seed oil content of rape are also significantly improved. Molecular mechanism research finds that VTP1 can directly interact with stem cell development star transcription factor WOX4 to form a molecular regulation module, and then promote the stem vascular tissue development of rape. The application provides the application and corresponding breeding technology of VTP1 in vascular engineering design and rape breeding, and provides a new key target and practical technical scheme for molecular design breeding of high-yield rape, and has important scientific theoretical significance and breeding application value.

The invention discloses a manufacturing method of a cinnamon vascular tissue paraffin section. According to the method, a self-adaptive gradient heating wax dipping technology is adopted, and the texture difference of cinnamon materials in different development stages from tender shoots to semi-lignified stems can be adapted. According to the method, the traditional chemical softening step is abandoned, the authenticity of the original components and the microstructure of the vascular tissue is completely reserved, and the slide preparation period is remarkably shortened. The paraffin section prepared by the method is high in tissue and cell morphology integrity, high in dyeing contrast and real. In addition, the method is reasonable in process design, effectively reduces dependence on expensive equipment, has universality and high efficiency, and solves the problems that the cell structure is damaged due to dependence on chemical softening and the requirements of soft and hard material slices are difficult to consider in the traditional method.

This specification provides a method and system for extracting the mechanical features of vascular tissue, comprising the following steps: multi-level stress loading: applying a multi-level external stress sequence to a superficial vascular region via a force-controlled actuator; steady-state verification: monitoring the stress signal at the contact interface in real time after each level of stress loading; temporal synchronous triggering: sending a trigger command to the ultrasound probe only when the mechanical boundary is determined to be in a steady state; modulus calculation: calculating the tissue elastic modulus based on imaging sampling data; multi-level looping: repeating the above steps to complete the elastic modulus measurement under multi-level stress conditions; response feature extraction: constructing a response relationship based on the stress-elasticity dataset and extracting feature parameters characterizing the nonlinear mechanical behavior of the tissue. By establishing a triple steady-state verification mechanism, a deterministic temporal synchronous coupling relationship is constructed between the mechanical state determination and the SWE excitation command, and the nonlinear elastic response features of the tissue are obtained under multi-level controllable stress conditions.

The invention relates to the field of medical instruments, in particular to minimally invasive heart radiofrequency ablation forceps which comprise two clamping arms capable of being close to each other for clamping, universal arms are arranged on the two clamping arms, knobs are arranged at one ends of the universal arms, the knobs are rotationally arranged on the clamping arms, and the knobs are fixedly connected with locking steel wires of the universal arms. The ablation electrodes are arranged on the sides, clamping the vascular tissue, of the two universal arms, the universal arms are in a soft state under the normal condition, the tissue cannot be punctured when the universal arms are placed into the thoracic cavity, and due to the fact that the universal arms are high in soft degree, the angle can be adjusted at will, and the coverage range is large, the universal arms can be placed at the secret position; during an operation, the device can be guided and placed through a special tool, after the device is placed, the locking steel wires in the universal arms are tightened by rotating the rotary knobs, the shapes of the universal arms are fixed, then the clamping arms are controlled to be close to each other, the ablation electrodes on the two universal arms are close to each other, finally, the ablation electrodes are powered on, and ablation operation is carried out according to the radio frequency ablation principle.

The utility model discloses a pair of vascular tissue closing forceps capable of being adjusted at any angle, which relates to the field of medical equipment and comprises a right hand holding type piece, a left hand holding type piece, a traction rod, a hinge connecting piece, a long catheter, an outer U-shaped head, a driving mechanism, a forceps head, a screwing head, a perforating seat, an inner U-shaped head, a forceps head regulating and controlling steel wire and a lateral rotation regulating and controlling steel wire. The blood vessel fixing device has the advantages that the two driving mechanisms are used for driving the outer U-shaped head and the inner U-shaped head which are connected to the two driving mechanisms to be in a lateral rotation state respectively, the forceps heads at the ends of the blood vessel fixing device can be adjusted at any angle, and the sight blocking area of the structural part of the blood vessel fixing device is laterally moved out through the forceps heads; and the barrier-free property of a blood vessel fixing operation visual field area is ensured.

The invention discloses a method for constructing a multi-scale early atherosclerosis in-vitro model, and belongs to the technical field of biomedical engineering and tissue engineering. The method comprises the following steps: providing an embedded suspension medium, wherein the suspension medium has adjustable yield stress, high optical transparency and reversible shear recovery performance; providing at least two kinds of bio-ink, wherein the bio-ink is respectively used for constructing different layers of the vascular tissue; using a multi-channel coaxial nozzle to programmably extrude the bio-ink in the embedded suspension medium so as to form a tubular tissue with a layered structure; after printing is completed, the suspension medium is removed through a physical or chemical method, and the tubular tissue is released. The model obtained through the method provides an in-vitro research platform which is highly bionic and high in controllability for disease mechanism research, drug screening and personalized medical treatment.

Disclosed herein is a method of isolating a stem cell line derived from a tissue from a primary meristem in a leaf of a plant, including the steps of sterilizing at least a part of the leaf containing the central or other vein; cutting through the central or other vein of the leaf to expose primary meristematic cells from the central or other vein inner vascular tissue; and culturing cells from said exposed cells, which circumvents the difficulties of surface sterilization when other types of explants are used. Also disclosed herein are stem cell lines obtained using the method.

The invention discloses a full-automatic intracavitary thermal closure treatment system which is used for treating varicosity and comprises a driving device, a rubber coating roller, an ablation catheter, a support, an ablation generating device, a control signal line and an output line, the driving device and the rubber coating roller are both installed on the support, and the rubber coating roller comprises a driving wheel and a driven wheel in transmission connection with the driving wheel; the driving device is connected with the driving wheel, the ablation catheter is inserted between the driving wheel and the driven wheel and is tightly engaged between the driving wheel and the driven wheel through friction force generated between the driving wheel and the driven wheel, when the driving device rotates, the ablation catheter is driven by power through the rubber-coated roller to enter or retreat, and the ablation generating device is connected with the ablation catheter through an output line. And the control signal line is connected with the driving device, so that the rotating speed of the driving device is controlled, the line feeding or withdrawing speed of the ablation catheter is adjusted, and the ablation catheter heats the blood vessel tissue to close the blood vessel. The device has the advantages of high automation degree and good treatment effect.

The invention discloses a small molecular short peptide for resisting vascular remodeling caused by Zika virus and application of the small molecular short peptide. The small molecule short peptide is constructed by fusing a cell-penetrating peptide and a functional amino acid sequence, and the amino acid sequence is shown as SEQ ID NO.1. The oligopeptide can be used for preparing drugs for preventing or treating vascular diseases induced by virus infection, especially for aorta vascular intimal hyperplasia and phenotype conversion of vascular smooth muscle cells from a contraction type to a synthetic type. The oligopeptide can reduce the crotonylation modification level of MYH9 protein in vascular smooth muscle cells and promote expression of alpha-smooth muscle actin and smooth muscle 22 alpha protein in vascular tissues, so that vascular pathological damage caused by virus infection is improved, the blood vessel thickness is reduced, and the ratio of a medial membrane to an intimal membrane is increased. The invention also provides a pharmaceutical composition containing the small molecule oligopeptide. The invention provides a new treatment strategy for prevention and treatment of virus infection related vascular diseases.

A vascular tissue model, and a method of modeling a vascular tissue system, comprising a rigid 3D printed scaffold, the scaffold comprising: one or more scaffold microfluidic channels; two or more inlets; and a central chamber, wherein the central chamber contains a hydrogel, wherein the hydrogel contains a hydrogel microfluidic channel.

The invention belongs to the technical field of bioengineering, and provides a tobacco vascular tissue specific expression promoter pNtERD6L and application thereof, the nucleotide fragment of the promoter pNtERD6L is cloned, a pNtERD6L + GUS expression vector is constructed, agrobacterium tumefaciens-mediated tobacco genetic transformation is carried out, the effect of the promoter pNtERD6L in tobacco plants is evaluated, and the application of the promoter pNtERD6L in the tobacco plants is promoted. Results show that the promoter pNtERD6L can drive a target gene to be specifically expressed in the tobacco vascular tissue, so that adverse effects caused by continuous and efficient expression of an exogenous gene driven by a constitutive promoter in other tissues of the tobacco are avoided.

This surgery assistance device comprises: an inference unit that inputs a surgical field image including an image of a vascular tissue to be anastomosed to a trained model as an inference target image, acquires coordinates of a stump of the vascular tissue in the surgical field image from the trained model as one inference result, and further acquires intimal damage information of the vascular tissue from the trained model as one inference result; an assistance image processing unit that superimposes an image indicating a region of the stump and an image indicating intimal damage information in the surgical field image on the surgical field image on the basis of the coordinates of the stump and the intimal damage information that have been acquired, and generates an advice image including a character string image according to a damage level of the intimal damage information, to generate an assistance image for an anastomosis surgery of the vascular tissue; and an output unit that causes a display device to display the assistance image.

A mapping and ablation catheter is presented. The mapping and ablation catheter comprising an elongated catheter shaft and an ablation portion being arranged at a distal end of the catheter shaft, wherein: the ablation portion comprises a plurality of loop segments; at least one first loop segment of the plurality of loop segments exhibits one or more ablation electrodes, the one or more ablation electrodes being configured for delivering energy to vascular tissue; the loop segments together form a three-dimensional spiral; and respective diameters of the loop segments are such that each loop segment rests on a neighboring loop segment when the three-dimensional spiral is compressed. The plurality of loop segments comprises a stabilizer loop segment, which does not does not exhibit any electrodes, wherein the stabilizer loop segment is the most proximal loop segment of the plurality of loop segments.

The application discloses a kind of methods for constructing deep vein thrombosis mouse model by regulating Pyk2 gene expression.The method comprises the following steps: constructing knockdown or overexpression vector for Pyk2 gene; by tail vein injection, the vector is introduced into mouse in vivo, the in vivo transient regulation of Pyk2 gene is realized; the inferior vena stenosis method is used to induce deep vein thrombosis; the thrombus macroscopic morphology, wet weight, length and histopathology are detected.The application overcomes the limitation of existing gene knockout model, such as congenital, irreversible and systemic deletion, realizes the targeted, temporary and bidirectional flexible regulation of Pyk2 gene in vascular tissue, and the model has high stability and good repeatability.The model can simulate the pathological state under the same expression level of Pyk2, and is suitable for the screening, evaluation and deep vein thrombosis pathogenesis research of antithrombotic drugs.