35 results about "Calcified lesion" patented technology

Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are systems and kits for practicing the subject methods. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

A method and system for transcatheter aortic valve implantation (TAVI) planning is disclosed. An anatomical surface model of the aortic valve is estimated from medical image data of a patient. Calcified lesions within the aortic valve are segmented in the medical image data. A combined volumetric model of the aortic valve and calcified lesions is generated. A 3D printed model of the heart valve and calcified lesions is created using a 3D printer. Different implant device types and sizes can be placed into the 3D printed model of the aortic valve and calcified lesions to select an implant device type and size for the patient for a TAVI procedure. The method can be similarly applied to other heart valves for any type of heart valve intervention planning.

The invention discloses a cancer diagnosis system and method based on breast molybdenum target calcification characteristics. The method comprises a first step of acquiring a breast molybdenum targetx-ray data set; a second step of carrying out image enhancement processing on each image in the breast molybdenum target x-ray data set respectively, and carrying out binaryzation segmentation to obtain a calcified lesion area; a third step of carrying out feature extraction on the calcified lesion area subjected to image enhancement processing and binaryzation respectively to obtain traditional features and depth features; a fourth step of performing typical correlation analysis on the traditional features and depth features, deleting the depth features with the low association weight with the traditional features, and saving the depth features which are closely related to the traditional features; a fifth steps of carrying out support vector machine linear classification model training for the saved depth features to obtain a classifier. According to the method, over-fitting of a traditional convolutional neural network on the calcification diagnosis of the breast molybdenum targetscan be effectively avoided, and automatic diagnosis of the molybdenum target image lesion at any resolution is realized.

Disclosed is a balloon catheter system. The balloon catheter system comprises a catheter, a buffer tube and a balloon assembly for enhancing the cutting effect, wherein the balloon assembly comprisesa balloon and a metal net wrapping the balloon; the metal net comprises a connecting near end, a connecting far end and an action section connected between the connecting near end and the connecting far end, wherein the connecting far end is connected with the far end of the balloon; a plurality of auxiliary cutting elements are dispersedly arranged on the action section; the catheter penetrates through the buffer tube and is connected with the near end of the balloon; and the near end of the buffer tube is connected outside the catheter, and the far end of the buffer tube is connected with the near end of the catheter. The device is accurate in positioning in the blood vessel, can provide expansion force far larger than that of a traditional structure, can effectively expand a highly calcified lesion part, improves the medicine utilization rate, reduces blood vessel damage, reduces the restenosis rate, and is worthy of application and popularization in the field.

The present inventors carried out immunization using renal/urinary calculus-derived calcified globules or carotid artery-derived arteriosclerotic plaques, and then obtained antibodies specific to calcified globules (NLO) via screening with NLO. The present inventors demonstrated that the antibodies reacted specifically to arteriosclerotic lesions (calcified lesions) and visualized arteriosclerotic plaques (in particular, calcified lesions) by using fluorescently labeled antibodies. Accordingly, the present inventors completed the present invention.

The invention discloses an indented balloon for vascular calcification plaques, which comprises a balloon body used for expanding a vascular wall; a indentation structure which is mounted on the outer surface of the balloon body, wherein the indentation structure comprises at least one indentation filament body, and the at least one indentation filament body is spirally arranged on the balloon body in a sleeving mode in the axial direction of the balloon body; in the radial direction of the balloon body, the free end of at least one indented filament body is spine-shaped; and in an expansion state, the free end of the indentation filament body is in contact with the calcified plaque. When the balloon body is conveyed to a calcified plaque lesion position, the spiral indented filament bodies can form a sliding effect, and the balloon body is promoted to smoothly pass through the calcified lesion position. The indented filaments on the outer surface of the balloon body are spiral, so that overhigh tension cannot be locally formed, the risk of complications such as vascular interlayer and vascular perforation is reduced, and the safety is improved. In addition, the free ends of the indentation filament bodies can generate impact force on the calcified plaque, so that the calcified plaque forms cracks and is separated from the blood vessel wall, and therefore, the treatment effect of the calcified plaque is improved.

The invention discloses a repair balloon for treating thrombus and calcification lesion, which comprises a balloon body, a cutting piece, a guide tube and a collecting tube, the balloon body is provided with a first connecting section and two ends of the balloon body are opened, the cutting piece extends along the peripheral surface of the balloon body and is partially and fixedly connected with the periphery of the balloon body. The guide tube is communicated with the first connecting section of the balloon body, the converging tube is arranged on the outer surface of the guide tube in a sleeved mode, and the near end of the cutting piece is converged in the converging tube and can slide relative to the converging tube. The repairing balloon is small and ingenious in structure and high in applicability, damage to the blood vessel wall in the operation process can be reduced, the repairing balloon can smoothly pass through a tortuous blood vessel and reach a focus to implement cutting, the operation time is shortened, the use experience of a user is enhanced, the repair balloon for treating thrombus and calcification lesions can be popularized and applied in the technical field of medical instruments.

The invention provides a rotary cut guide wire and a calcification lesion tearing device. The rotary cut guide wire comprises a guide wire body, a plurality of cutting pieces and at least one attaching piece, wherein the cutting pieces and the attaching piece are arranged on the guide wire body. The multiple cutting pieces are arranged in the circumferential direction of the guide wire body, one side of each cutting piece is rotationally connected with the guide wire body, the other side of each cutting piece is provided with a cutting edge, and the cutting edges are away from the guide wire body when the cutting pieces rotate relative to the guide wire body. The attaching piece enables multiple cutting pieces to be gathered on the surface of the guide wire body, the cutting pieces are not prone to scratching blood vessels when entering the blood vessels along with the guide wire body, and safety is high. A medical worker conveys the cutting pieces to the calcification lesion position through the guide wire body, then the guide wire body is further rotated, the side, connected to the guide wire body, of the cutting pieces is driven to rotate, and the cutting edges of the cutting pieces are blocked by the calcification lesion and do not rotate along with the guide wire body. The cutting pieces overcome the acting force of the attaching piece and rotates relative to the guide wire body, the cutting pieces are gradually unfolded from the folded state, and the cutting edges are gradually away from the guide wire body and cut into the calcification lesion.

The invention provides an intravascular ultrasonic imaging catheter and system with foresight capability. The catheter comprises a sheath tube (10), a guide wire cavity (20), a flexible driving shaft (30) and a transducer module, wherein the guide wire cavity (20) is arranged on the outer side surface of the sheath tube (10); the first end of the flexible driving shaft (30) is used for being electrically connected with a driving device (100), so that the flexible driving shaft (20) is driven by the driving device (100) to rotate in the sheath tube (10); the transducer module is arranged at the second end of the flexible driving shaft (20) and comprises a lateral ultrasonic device (41) and a forward ultrasonic device (42); and the lateral ultrasonic device and the forward ultrasonic device are both used for being electrically connected with an ultrasonic host (200) so as to transmit obtained imaging electric signals to the ultrasonic host or receive excitation electric signals transmitted by the ultrasonic host. The intravascular ultrasonic imaging catheter solves the problems that when a guide wire of a traditional intravascular ultrasonic imaging catheter penetrates, subintimal hematoma or interlayer may be caused, the guiding effect of the catheter is affected by serious calcification lesion, and the operation of guide wire penetrating is tedious and time-consuming.

The invention relates to the technical field of coronary rotational atherectomy, and particularly relates to a rotational atherectomy interventional treatment instrument for treating a coronary arterycalcification lesion. The rotational atherectomy interventional treatment instrument comprises a rotational atherectomy instrument host, a pedal control board, a nitrogen tank, a propeller, a rotational atherectomy catheter and a rotational atherectomy guide wire; a speed reduction switch is arranged on the pedal control board, and the outside of the pedal control board is communicated with a speed reduction control pipe and two ventilation hoses; a gas outlet connector is arranged at the top end of the nitrogen tank, and the gas outlet connector is communicated with a nitrogen interface by agas supply pipe; the propeller comprises a machine body, a moving handle, an optical fiber rotation speed connection cable, a saline solution input pipe and a gas connection pipe; a strip slot is formed on the upper end face of the machine body; the moving handle is mounted in a sliding mode inside the strip slot; scale lines are also formed on both front and rear sides of the strip slot; and a handle travel control structure is also mounted in a sliding mode on the machine body. According to the invention, a forward distance of a rotational atherectomy head can be limited, so as to effectively avoid a deviation generated due to artificial control on the front and rear process of the rotational atherectomy head and protect a coronary artery canal behind the calcification lesion position from being damaged.

A medical device may include an elongated body, a balloon positioned at a distal portion of the elongated body, and one or more pressure-wave emitters positioned along a central longitudinal axis of the elongated body within the balloon. The one or more pressure-wave emitters may be configured to propagate pressure waves radially outward through the fluid to fragment a calcified lesion at the target treatment site. The at least one of the one or more pressure-wave emitters may include an electronic emitter comprising a first electrode and a second electrode. The first electrode and the second electrode may be arranged to define a spark gap between the first electrode and the second electrode, and the second electrode may comprise a portion of a hypotube.

The invention provides a medical robot operation device, and relates to the technical field of medical robots. The device comprises a rotating part, a transmission part, a driven part, a sensor and a shell, the rotating part is mounted outside the shell; the driven part is installed in the shell, and the rotating part drives the driven part to rotate through the transmission part. The sensor is installed in the shell and used for monitoring the real-time motion state of the passive component and then transmitting the real-time motion state to an external controller, and the controller controls the medical robot execution end to execute the operation of delivering the interventional instrument. The interventional instrument is controlled to advance or retreat through the rotating component, operation is convenient, and the progressive distance can be more easily and accurately controlled; besides, the sliding direction of the rotating component is quickly switched, so that the interventional instrument can quickly shake back and forth, the common puncturing action in an interventional operation is realized, and particularly, the interventional instrument can pass through a blood vessel part with a calcified lesion or a complex lesion.

The invention discloses an intervention type medical catheter component welding method and a medical catheter, a catheter component comprises a catheter body and a guide end located at the far end of the catheter body, and the welding method comprises the following steps that at least two tip tubes which can be arranged together in a sleeved mode are provided; sleeving the guide end of the tube body with a first-layer tip tube, and fixing the first-layer tip tube on the tube body in a welding manner; sleeving the first-layer tip tube with a second-layer tip tube, and welding the second-layer tip tube on the first-layer tip tube; by parity of reasoning, a plurality of tip tubes are nested and welded on the tube body, so that a tip head is formed at the guide end of the tube body; by the adoption of the welding method, the guide end of the tube body can be firmer and more durable, serious calcification lesion can be more easily penetrated, and the success rate of an interventional operation is increased.

The invention discloses an intravascular calcification lesion rotary grinding device, and aims to improve the safety of an operation and reduce the cost. According to the technical scheme, the rotary grinding equipment for the intravascular calcification lesion is provided with a rotary grinding head and is characterized in that the rotary grinding head is driven by a water pump through a water turbine to rotate. Compared with the prior art, high-pressure liquid is adopted to impact the water wheel to convert liquid kinetic energy into water wheel rotation mechanical energy, the transmission acceleration mechanism is driven to achieve rotation of the rotary grinding head, and the rotary grinding head is used for dredging or improving severe and narrow severe calcification or fibrosis atherosclerotic lesions on the periphery of a human body and in coronary vessels. The rotary grinding head rotates at a high speed, transmission noise is low, friction heat left in the human body due to rotary grinding is reduced, the amount of cooling and lubricating solution input into the human body is reduced, the metabolic burden of the kidney of the human body is relieved, and the rotary grinding head is safe, reliable, simple in structure and low in cost.

The method for treating cardiovascular disease relates to stopping growth of an atherosclerotic plaque or lesion. A therapeutically effective amount of a pharmaceutically acceptable gallium compound is administered to an inflammation site in an artery with a lesion with microcalcifications. Gallium ions bind to the lesion. The proper amount of gallium compound delivered to the lesion disrupts a calcification process at the inflammation site. The gallium ions bind to calcium hydroxyapatites in microcalcifications so that the microcalcifications can no longer differentiate into early phase osteoblasts. The gallium integrated into the calcium structures at the inflammation site has a lasting effect to reduce atherosclerotic plaques.

The invention relates to a multifunctional balloon catheter system for cardiovascular stenosis. The multifunctional balloon catheter system comprises a distal end balloon catheter, a proximal end catheter, a handle and an energy generator; the distal end balloon catheter is connected with one end of the proximal end catheter; the other end of the proximal end catheter is connected with the handle; the handle is connected with the energy generator through a cable line; and the energy generator controls energy release of an electrode pair. A balloon with the electrode pair releases energy, a calcinosis lesion is shattered by generated energy shock waves, and drugs are released into vascular walls for absorption; and meanwhile, the length of the distal end balloon catheter can be adjusted for drug release according to a position of a vascular lesion, so that anti-regeneration drugs can be coated at stenosis positions for a multi-lesion position, and unblocked blood vessels are achieved. According to the multifunctional balloon catheter system for the cardiovascular stenosis, the operation is simple and easy, vascular stenosis and calcinosis are effectively treated, and long-term smoothness is achieved.

The invention discloses a bi-level compliant medical balloon. At the first level (in a low pressure range), the diameter of the balloon changes rapidly, and the diameter of the balloon can be precisely controlled by controlling the pressure, namely, in the expansion pressure range from the nominal pressure to the nominal pressure + of about 6 atm, and the balloon has the expansion rate of 6-11%, preferably 8-10% in the diameter direction; and at the second level (in a high pressure range), the diameter of the balloon is small, the pressure can be centralized to fully expand a lesion (especially a severely calcified lesion) or allow a stent to fully expand and adhere to the wall, meanwhile the damages to the inner surfaces of blood vessels are decreased, namely, in the expansion pressure range from the nominal pressure + of about 6 atm to the nominal pressure + of about 14 atm, and the balloon has the expansion rate of 4-8%, preferably 4-6% in the diameter direction. The balloon can beused for both pre-expansion and post-expansion.