18 results about "Vascular calcification" patented technology

Use of 1-methylnicotinamide in preparation of an anti-vascular calcification drug. It is found that the small molecule metabolite 1-methylnicotinamide has an effect of inhibiting vascular calcification and its progress, which provides a new idea for treatment of vascular calcification. Moreover, 1-methylnicotinamide has good drug safety and a strong vascular calcification inhibition effect, and can be used as a candidate drug for inhibiting vascular calcification. In addition, 1-methylnicotinamide is a known small molecule metabolite that is soluble in water or DMSO, has good stability, low cytotoxicity and good drug safety, and can be flexibly administrated in various modes such as oral administration and intravenous injection.

A biological nanoparticle for targeted therapeutic delivery is provided. The biological nanoparticle includes a plurality of extracellular vesicles. Characteristically, each extracellular vesicle contains a microRNA, which has been modified with ExoMotif sequences to enhance selective loading into the vesicles during their biogenesis. The microRNA is configured to inhibit plaque formation and vascular calcification. Additionally, a hydroxyapatite-binding peptide (HABP) is conjugated to the surface of each extracellular vesicle, facilitating targeted delivery to calcified tissues. This configuration enables the nanoparticle to specifically target areas of vascular calcification, where it can deliver the microRNA to modulate cellular behavior.

The present invention relates to a pharmaceutical composition containing Cbfβ (Core-binding factor subunit beta) expressing vascular smooth muscle cells or a culture fluid thereof as an active ingredient for the prevention or treatment of age-related diseases. It has been found that inhibition of Cbfβ expression in vascular smooth muscle cells promotes vascular calcification and osteoclast differentiation and that the culture fluid of Cbfβ-expressing vascular smooth muscle cells inhibits osteoclast differentiation. Thus, the composition can be advantageously utilized as a pharmaceutical composition for the prevention, treatment, alleviation, or diagnosis of age-related diseases.

The invention belongs to the technical field of biological medicines, and discloses a gingko nano-targeting drug-loaded compound, a preparation method thereof and application of the gingko nano-targeting drug-loaded compound in prevention and treatment of vascular calcification. The invention discloses a ginkgo biloba nano-targeting drug-loaded compound which comprises a ginkgo biloba extract, a nano-carrier and targeting peptide. According to the ginkgo biloba nano-targeting drug-loaded compound provided by the invention, the ginkgo biloba extract is combined with targeting peptide (such as hydroxyapatite binding peptide), so that the ginkgo biloba nano-targeting drug-loaded compound has the capacity of targeting vascular calcification, and the purpose of targeted therapy is achieved. Experimental research proves that for high-phosphorus-induced calcified male mice and HASC-induced calcification models, the gingko nano-targeting drug-loaded compound provided by the invention can effectively relieve vascular calcification, has relatively high safety and is expected to be applied to prevention and treatment of vascular calcification diseases. The invention provides a new thought and prevention and treatment direction for treating vascular calcification.

The invention relates to the field of in-vitro diagnostic reagents, in particular to application of a reagent for detecting ACVR2b in preparation of a chronic kidney disease vascular calcification diagnostic kit. It is found for the first time that the expression quantity of ACVR2b is remarkably associated with chronic kidney disease vascular calcification. Therefore, the expression quantity of the ACVR2b can be used for screening the vascular calcification of the chronic kidney disease. On the basis, the invention provides application of a reagent for detecting ACVR2b in preparation of a chronic kidney disease vascular calcification diagnostic kit, and the reagent has a good application prospect.

This invention provides a polypeptide for treating vascular calcification, belonging to the field of biotechnology. By analyzing lncRNA sequencing results from patients with chronic kidney disease exhibiting varying degrees of vascular calcification, this invention reveals for the first time a long non-coding RNA (lncRNA)—LINK-A—highly expressed in these patients. Furthermore, it confirms that LINK-A endogenously expresses a 40-amino acid-residue polypeptide—PKM2-associated polypeptide (PKM2AP)—in its second ORF. Subsequently, in vitro and in vivo experiments validated the important role of this polypeptide in inhibiting vascular calcification. This invention not only provides a novel target (LINK-A) for vascular calcification but also offers a potential drug (PKM2AP) for treating vascular calcification.

A microporous electrode for disruption treatment of vascular calcification, comprising an outer balloon strip (1). A conductive tube (2) penetrates and is connected to an interior of the outer balloon strip (1). A side surface of the conductive tube (2) is provided with a sealing ring seat (32), and the sealing ring seat (32) is fixedly connected to the outer balloon strip (1). The side surface of the conductive tube (2) is provided with a top liquid inlet hole (10), and the top liquid inlet hole (10) is located on the side surface of the internal conductive tube (2) of the outer balloon strip (1); a bottom liquid inlet hole (11) is provided on the side surface of the conductive tube. By enabling a flow of a liquid capable of generating a discharge medium inside the outer balloon strip (1) to be unhindered by a liquid level height, the normal use of the microporous electrode in the disruption treatment of vascular calcification is ensured.

This invention discloses a medical image segmentation method for urinary stones based on region connectivity, belonging to the field of medical image processing technology, to solve the problems of high-density bone interference and topological fragmentation in stone segmentation. First, a piecewise weighted mapping function is constructed to adaptively adjust the window width and perform anisotropic filtering on the image, generating a bone suppression feature map. Then, a maximum stable extremum region algorithm combined with anatomical priors is used to extract high-confidence seed points. A fast traversal algorithm is executed using a constructed gradient resistance field to detect geodesic temporal field abrupt changes to define boundaries, generating a simply connected mask. Finally, three-dimensional dense morphology and texture consistency features are fused for weighted discrimination to remove vascular calcification artifacts. This invention ensures the topological connectivity and high accuracy of the segmentation results.

The application belongs to the technical field of medical apparatus and specifically discloses an electromagnetic pulse type shock wave balloon and a vascular interventional treatment instrument, the electromagnetic pulse type shock wave balloon comprises a medical balloon and a medical catheter, a micro disc type coil is arranged in the medical balloon, a conductive wire is arranged in the medical catheter, the conductive wire is connected with the micro disc type coil, and a metal patch is arranged on the inner wall or the outer wall of the medical balloon and corresponds to the micro disc type coil; the micro disc type coil is connected with an external power supply through the conductive wire, the external power supply provides pulse current to flow through the micro disc type coil, an alternating magnetic field is excited, the metal patch generates an eddy current in the magnetic field, the eddy current generates a repulsive force in the magnetic field, the metal patch is pushed to move, the metal patch drives the balloon wall surface to expand and contract, and an outward radiation of a shock wave is formed. The electromagnetic pulse type shock wave balloon is convenient to manufacture, low in cost, longer in service life and stable in shock wave energy, and is a novel shock wave balloon for vascular calcification treatment.

The invention relates to the field of in-vitro diagnostic reagents, in particular to application of a reagent for detecting TNN in preparation of a chronic kidney disease vascular calcification diagnostic kit. It is found for the first time that the expression quantity of TNN is remarkably associated with chronic kidney disease vascular calcification. Therefore, the expression quantity of the TNN can be used for screening the vascular calcification of the chronic kidney disease. On the basis, the invention provides application of the TNN detection reagent in preparation of the chronic kidney disease vascular calcification diagnosis kit, and the application prospect is good.

The present application relates to the field of in vitro diagnostic reagents, in particular to the use of reagents for detecting ACVR2b in the preparation of a diagnostic kit for chronic kidney disease vascular calcification, and it is found for the first time that the expression level of ACVR2b is significantly correlated with chronic kidney disease vascular calcification. Therefore, the expression level of ACVR2b can be used for screening of chronic kidney disease vascular calcification. Based on this, the present application provides the use of reagents for detecting ACVR2b in the preparation of a diagnostic kit for chronic kidney disease vascular calcification, which has a good application prospect.

A catheter system (100) for treating a treatment site (106) within or adjacent to a blood vessel (108) includes a power source (124), a light guide (122), and a plasma target (242). In various embodiments, the light guide (122) receives power from the power source (124). The light guide (122) has a distal tip (244), and the light guide (122) emits light energy (243) in a direction away from the distal tip (244). The plasma target (242) is spaced apart from the distal tip (244) of the light guide (122) by a target gap distance (245). The plasma target (242) is configured to receive light energy (243) from the light guide (122) such that plasma bubbles (234) are generated at the plasma target (242). The power source (124) may be a laser, and the light guide (122) may be an optical fiber. The catheter system (100) may also be an inflatable balloon (104) surrounding the distal tip (244) of the light guide (122). The plasma target (242) may have a target surface (1672) that receives the light energy (243) from the light guide (122). The plasma target (242) may be formed from one or more of tungsten, tantalum, platinum, molybdenum, niobium, iridium, magnesium oxide, beryllium oxide, tungsten carbide, titanium nitride, titanium carbonitride, and titanium carbide.

The present invention belongs to the technical field of vascular intervention, and specifically relates to a vascular calcified plaque cutting device, comprising a rotating assembly, wherein a suction assembly is fixedly connected to the middle part of the outer surface of the rotating assembly, a sliding groove is formed in the lower surface of the suction assembly, first electromagnetic blocks are fixedly connected to both ends of the sliding groove, a sealing assembly is slidably connected to the middle part of the sliding groove, a second electromagnetic block is attached to the lower surface of the sealing assembly, and a gas supply assembly is fixedly connected to the lower surface of the second electromagnetic block. In the vascular calcified plaque cutting device of the present invention, by means of the provided suction assembly, during the rotational grinding of calcified plaques by the rotating assembly, fan blades rotate synchronously with a drive shaft, creating a negative pressure state above the fan blades, and thereby attaching the ground-off calcified plaques to the area below the fan blades; in this way, the ground-off calcified plaques can be removed immediately, thereby preventing same from affecting the rotational grinding by a grinding wheel and causing deviation in the path of the grinding wheel, affecting usage; in addition, after the rotational grinding is completed, a ballon is inflated.

The application discloses application of a compound Isaridin E or a pharmaceutically acceptable salt thereof in preparation of anti-vascular calcification drugs and related diseases, and relates to the field of medicine and biotechnology.The application adopts a classic high-phosphate-induced smooth muscle cell calcification model and a high-dose vitamin D3 (VitD3)-induced in-vivo vascular calcification model, and finds that the compound Isaridin E has a significant improvement effect on vascular calcification caused by calcium and phosphorus metabolism disorder through in-vitro cell experiments, in-vitro experiments and whole animal experiments.The drug action can significantly inhibit high-phosphate and vitamin D3-induced vascular smooth muscle cell osteogenic differentiation, inhibit vascular calcification, and significantly reduce the formation of calcium and phosphorus crystals in a vascular wall.The application develops a brand-new medical use of the marine compound Isaridin E, and can be used for research and development of drugs for treating vascular calcification and calcification-related diseases.

The present application relates to the field of in vitro diagnostic reagents, in particular to the use of a reagent for detecting TNN in the preparation of a diagnostic kit for chronic kidney disease vascular calcification, and it is found for the first time that the expression level of TNN is significantly correlated with chronic kidney disease vascular calcification. Therefore, the expression level of TNN can be used for screening of chronic kidney disease vascular calcification. Based on this, the present application provides the use of a reagent for detecting TNN in the preparation of a diagnostic kit for chronic kidney disease vascular calcification, which has a good application prospect.

Calcium-binding compositions and methods of treating vascular calcifications using the calcium-binding compositions are disclosed herein. The calcium-binding compositions include a water-soluble biopolymer, such as collagen, and a calcium-binder. The methods of treating vascular calcifications include delivering a calcium-binding composition including a water- soluble biopolymer, such as collagen, and a calcium-binder to a treatment site.

The invention discloses a shock wave vascular treatment catheter, and relates to the technical field of medical instruments. Comprising a base section, an extending section, a bag body and a shock wave generating assembly, the base section comprises a guide wire cavity, a first electrode cavity, a second electrode cavity, a liquid inlet cavity and a liquid outlet cavity (a first circumferential arrangement area), and the first electrode cavity and the second electrode cavity are arranged around the guide wire cavity in the circumferential direction; the shock wave generating assembly includes a metal electrode, a first wire electrode extending through the first electrode lumen, and a second wire electrode (second circumferentially arranged region) extending through the second electrode lumen. The second circumferential arrangement area and the first circumferential arrangement area are arranged at an interval in the axial direction; the capsule body can be attached to a vascular calcification part; the first wire electrode, the second wire electrode and the metal electrode are only provided with conductive end faces facing the far end, so that forward discharging is achieved. The radial size is reduced, the passing ability of the base segment in the blood vessel is improved, and meanwhile forward discharging and attachment to the blood vessel wall can be achieved.

The application discloses a kind of gravel catheter and gravel equipment, gravel catheter includes body, at least one shock wave generator, at least one ultrasonic wave generator and control piece, shock wave generator and ultrasonic wave generator are set on body, control piece is electrically connected with shock wave generator and ultrasonic wave generator, control piece has the first state of control shock wave generator power-off while controlling ultrasonic wave generator power-on to generate vibration to body, or the second state of control shock wave generator and ultrasonic wave generator power-on simultaneously.Gravel catheter generates ultrasonic wave when working, and cavitation reaction occurs on blood vessel calcified plaque and constantly produces microbubble, and the microbubble generated by ultrasonic wave cavitation reaction has periodic expansion and contraction and high-frequency vibration, and expansion and contraction and high-frequency vibration will cause mechanical fatigue and damage to plaque, thereby improving treatment efficiency.