Preparation method of anti-vascular calcification degradable drug-carrying coated scaffold
A technology of anti-vascular calcification and drug-loaded coating, which is applied in the field of biomedical materials, can solve problems such as hindering the application of degradable metal stents, accelerating vascular calcification, and affecting calcium and phosphorus metabolism, so as to achieve excellent prevention and hinder the occurrence of vascular calcification, avoid Abnormal, low-cost preparation effects
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preparation example Construction
[0017] B. Preparation of drug coating on the surface of magnesium-based vascular stent
[0018] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto the magnesium stent, the atomized PTMC solution evaporates rapidly, forming a layer of uniform polymer on the surface of the magnesium stent drug-loaded film.
[0019] The drug-coated vascular stent with anti-vascular calcification function has excellent ability to prevent and hinder the occurrence of vascular calcification, has curative effect on reducing the complications of vascular atherosclerosis, and effectively reduces the potential damage caused by the degradable vascular stent....
Embodiment 2
[0021] A technology for preparing a degradable drug-loaded coating stent with anti-vascular calcification, the steps of which are:
[0022] A, preparation of calcium ion channel inhibitor cinacalcet (Sensipar), PTMC drug polymer solution
[0023] The mixture of PTMC (-(COOCH2CH2CH2-O)n-) and cinacalcet (mass ratio is 9:1) was dissolved in dichloromethane respectively, stirred with a magnetic stirrer to make it fully dissolved, and prepared into 0.5% ( volume ratio) mixed solution.
[0024] B. Preparation of drug coating on the surface of magnesium-based vascular stent
[0025] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto t...
Embodiment 3
[0028] A. Preparation of phosphate binder Sevelamer and PTMC drug polymer solution
[0029] Dissolve the mixture of PTMC (-(COOCH2CH2CH2-O)n-) and Sevelamer (mass ratio: 9:1) into dichloromethane, stir it with a magnetic stirrer to fully dissolve it, and make it 0.5% (volume ratio) mixed solution.
[0030] B. Preparation of drug coating on the surface of magnesium-based vascular stent
[0031] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto the magnesium stent, the atomized PTMC solution evaporates rapidly, forming a layer of uniform polymer on the surface of the magnesium stent drug-loaded film.
[0032] The drug-coated vas...
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