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Preparation method of anti-vascular calcification degradable drug-carrying coated scaffold

A technology of anti-vascular calcification and drug-loaded coating, which is applied in the field of biomedical materials, can solve problems such as hindering the application of degradable metal stents, accelerating vascular calcification, and affecting calcium and phosphorus metabolism, so as to achieve excellent prevention and hinder the occurrence of vascular calcification, avoid Abnormal, low-cost preparation effects

Active Publication Date: 2016-08-10
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the pre-research of animal and clinical trials of degradable stents, researchers found that the degradation of metals in the in vivo environment will affect the calcium and phosphorus metabolism inside and outside the cells, thereby promoting or accelerating the occurrence of vascular calcification
This has an adverse effect on the recovery of vascular function, and also limits and hinders the further application of degradable metal stents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] B. Preparation of drug coating on the surface of magnesium-based vascular stent

[0018] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto the magnesium stent, the atomized PTMC solution evaporates rapidly, forming a layer of uniform polymer on the surface of the magnesium stent drug-loaded film.

[0019] The drug-coated vascular stent with anti-vascular calcification function has excellent ability to prevent and hinder the occurrence of vascular calcification, has curative effect on reducing the complications of vascular atherosclerosis, and effectively reduces the potential damage caused by the degradable vascular stent....

Embodiment 2

[0021] A technology for preparing a degradable drug-loaded coating stent with anti-vascular calcification, the steps of which are:

[0022] A, preparation of calcium ion channel inhibitor cinacalcet (Sensipar), PTMC drug polymer solution

[0023] The mixture of PTMC (-(COOCH2CH2CH2-O)n-) and cinacalcet (mass ratio is 9:1) was dissolved in dichloromethane respectively, stirred with a magnetic stirrer to make it fully dissolved, and prepared into 0.5% ( volume ratio) mixed solution.

[0024] B. Preparation of drug coating on the surface of magnesium-based vascular stent

[0025] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto t...

Embodiment 3

[0028] A. Preparation of phosphate binder Sevelamer and PTMC drug polymer solution

[0029] Dissolve the mixture of PTMC (-(COOCH2CH2CH2-O)n-) and Sevelamer (mass ratio: 9:1) into dichloromethane, stir it with a magnetic stirrer to fully dissolve it, and make it 0.5% (volume ratio) mixed solution.

[0030] B. Preparation of drug coating on the surface of magnesium-based vascular stent

[0031] The magnesium-based vascular stent is fixed on a rotating metal needle with a rotation speed of 120r / min, and the metal needle moves left and right at a speed of 0.254cm / s to ensure that the surface of the magnesium stent is completely sprayed; Propelled at a speed of / min, there is a high-frequency vibration metal probe at the nozzle, the solution is vibrated into an atomized state, and sprayed onto the magnesium stent, the atomized PTMC solution evaporates rapidly, forming a layer of uniform polymer on the surface of the magnesium stent drug-loaded film.

[0032] The drug-coated vas...

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PUM

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Abstract

The invention discloses a preparation method of an anti-vascular calcification degradable drug-carrying coated scaffold. With a medical metal vascular scaffold as a base body, the surface of the vascular scaffold material is coated with a dissolution-erosion high-molecular material and an anti-vascular calcification medicine composite, and then the vascular scaffold is dried and sterilized to obtain the vascular scaffold having a calcium-phosphorus metabolism sustained medicine releasing coating. The anti-vascular calcification degradable drug-carrying coated scaffold has excellent capability of preventing and inhibiting vascular calcification, has curative effects of reducing complications of blood vessel atherosclerosis, and meanwhile effectively reduces potential risk of causing the vascular calcification by the degradable vascular scaffold.

Description

technical field [0001] The invention relates to biomedical materials, in particular to the technical field of preparing a degradable drug-loaded coating stent with anti-vascular calcification. Background technique [0002] Stenosis of cardiovascular and cerebrovascular diseases is the most important cause of complications of fatal cardiovascular and cerebrovascular diseases. Internationally, the current death toll of patients with cardiovascular and cerebrovascular diseases is 17 million per year, ranking first in human disease death. Percutaneous coronary intervention can restore the normal circulation of blood in narrowed vessels, and is the main way to treat atherosclerosis clinically. In the past 30 years, interventional treatment of cardiovascular and cerebrovascular diseases has developed from simple balloon dilatation and bare metal stents in the early stage to the current drug-eluting vascular stent and the future degradable vascular stent, which has reduced the res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/14A61L31/16
CPCA61L31/022A61L31/10A61L31/148A61L31/16A61L2300/204A61L2300/216A61L2300/416A61L2300/422A61L2300/602A61L2300/604A61L2300/606A61L2420/04C08L69/00
Inventor 赵安莎黄楠王进杨苹叶长荣
Owner SOUTHWEST JIAOTONG UNIV
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