Preparation method of anti-vascular calcification degradable drug-carrying coated scaffold

Abstract

The invention discloses a preparation method of an anti-vascular calcification degradable drug-carrying coated scaffold. With a medical metal vascular scaffold as a base body, the surface of the vascular scaffold material is coated with a dissolution-erosion high-molecular material and an anti-vascular calcification medicine composite, and then the vascular scaffold is dried and sterilized to obtain the vascular scaffold having a calcium-phosphorus metabolism sustained medicine releasing coating. The anti-vascular calcification degradable drug-carrying coated scaffold has excellent capability of preventing and inhibiting vascular calcification, has curative effects of reducing complications of blood vessel atherosclerosis, and meanwhile effectively reduces potential risk of causing the vascular calcification by the degradable vascular scaffold.

Description

technical field

[0001] The invention relates to biomedical materials, in particular to the technical field of preparing a degradable drug-loaded coating stent with anti-vascular calcification. Background technique

[0002] Stenosis of cardiovascular and cerebrovascular diseases is the most important cause of complications of fatal cardiovascular and cerebrovascular diseases. Internationally, the current death toll of patients with cardiovascular and cerebrovascular diseases is 17 million per year, ranking first in human disease death. Percutaneous coronary intervention can restore the normal circulation of blood in narrowed vessels, and is the main way to treat atherosclerosis clinically. In the past 30 years, interventional treatment of cardiovascular and cerebrovascular diseases has developed from simple balloon dilatation and bare metal stents in the early stage to the current drug-eluting vascular stent and the future degradable vascular stent, which has reduced the res...