131 results about "Drug coating" patented technology

Methods of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject, methods of treating chronic rhinosinusitis (CRS) or chronic rhinosinusitis with nasal polyps (CRSwNP) in a human subject, methods of treating a eustachian tube disorder in a human subject, and devices and systems for performing the methods. A method of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject includes inserting a drug-coated balloon catheter into a target site in a trachea, mainstem bronchus, bronchus intermedius, lobar bronchus, segmental bronchus, or sub-segmental bronchus, wherein the balloon is coated with a coating layer including the therapeutic agent and one or more additives. The therapeutic agent includes paclitaxel, sirolimus, or a derivative thereof. The method includes inflating the balloon to dilate the airway and deliver a therapeutic agent to the airway wall. The method includes deflating the balloon. The method also includes withdrawing the balloon catheter from the target site.

Described herein are shock wave catheters and methods of use thereof for delivering an active agent of a drug to the CNS via a body lumen or cavity, such as sinonasal cavity, which can bypass the blood-brain barrier (BBB). The catheters described herein can be advanced through an intranasal passage to the nasal cavity such that at least a portion of the enclosure is disposed in the nasal cavity. The enclosure can be coated with a drug coating. The method can include filling the enclosure with a conductive fluid. At least one shock wave can be generated at a shock wave emitter of the catheter disposed within the enclosure. The at least one shock wave can cause a therapeutically effective amount of the active agent of the drug coating to be delivered to the CNS via tissue of the nasal cavity, in turn, treating central nervous system diseases.

The invention belongs to the technical field of medical instruments. The invention discloses a drug coating balloon catheter and a preparation method thereof. In one aspect, a drug coated balloon catheter includes a catheter with a balloon; a drug coating at least comprising an inner coating and an outer coating is arranged on the outer wall of the balloon, and the inner coating and the outer coating are provided with drug active ingredients and different carriers respectively; when the balloon is expanded, the inner coating and the outer coating are separated from the balloon through the state change of the temperature-sensitive carrier of the inner coating under the body temperature environment of a patient and the hydration effect, and the outer coating is used for promoting corresponding active pharmaceutical ingredients to be transferred into target tissues through the carrier of the outer coating when the outer coating is separated from the balloon. On the other hand, the invention provides a preparation method of the drug coating balloon catheter. The preparation method has the advantages that the adhesiveness of the drug coating on the balloon can be effectively improved so as to reduce the delivery loss, and the release rate of the drug coating on diseased tissues can be improved so as to improve the drug transfer capacity.

Covered stents may be coated with or otherwise include a drug eluting composition. An illustrative stent may comprise an elongated tubular body having a strut framework defining a plurality of open cells. A polymeric coating may be disposed on a surface of the elongated tubular body and extending across the plurality of open cells and a first drug coating composition disposed on a surface of the polymeric coating.

The invention relates to the technical field of medical instruments, in particular to a paclitaxel drug coating balloon dilatation catheter and a preparation method and application thereof.The paclitaxel drug coating comprises a substrate layer, a middle layer and an outer layer; the substrate layer comprises paclitaxel and a hydrophilic excipient; the middle layer comprises a lipophilic excipient and a temperature response type polymer; and the outer layer comprises a pH sensitive polymer. The substrate layer is combined with the surface of the balloon, so that excellent conveying stability is provided, the medicine is effectively prevented from falling off prematurely in the conveying process of the catheter, and the firmness of the coating is improved; a micropore network structure is formed in the middle layer, the network structure is expanded under the body temperature condition, the porosity is increased, slow release of the medicine is achieved, the absorption amount of the medicine on the blood vessel wall is effectively increased, and the medicine effect time is prolonged; the solubility of the outer layer is improved in a slightly acidic blood vessel wall environment, so that the release of the medicine is further promoted, and the effective release of the medicine on the blood vessel wall is ensured.

This invention relates to the field of tablet preparation technology, specifically to a drug coating state detection system and method. The system includes a surface pretreatment module, a coating execution module, an online monitoring module, a data processing module, and a control module. The pretreatment module removes contaminants and enhances activity through plasma treatment, thereby improving coating adhesion. The coating execution module uses a fluidized bed environment, combined with a multi-channel spray gun and attitude control, to achieve uniform coating. The online monitoring module simultaneously acquires three-dimensional morphology, spectral, and image data, suppressing interference to ensure reliability. The data processing module calculates thickness and uniformity indicators, using machine learning to correlate process and quality. The control module dynamically adjusts parameters based on quality parameters using a PID algorithm, initiating emergency handling in case of anomalies. The method corresponds to the above steps. This invention improves coating adhesion and uniformity, achieves real-time monitoring and precise control, reduces the difficulty and cost of quality control, and is applicable to the production of various functional tablet coatings.

The invention provides a pressure adjusting system and a method for adjusting the pressure of fluid in an inner cavity of medical equipment, and relates to a method for controlling a pressure control pump to enable the pressure of the fluid in the inner cavity of the medical equipment to change within a period of time. A coronary artery blood vessel remodeling catheter, a peripheral balloon dilatation catheter, a peripheral blood vessel remodeling catheter, an intracranial laser balloon dilatation catheter, a drug coating balloon dilatation catheter, a photodynamic balloon catheter, a mastoid balloon catheter, a constraint type balloon dilatation catheter and a spinous process balloon can be made. Expansion and contraction of a balloon body in a balloon catheter such as a drug delivery balloon catheter are regularly changed within a period of time, and therefore the treatment effect is better achieved.

The utility model relates to medical instrument technical field, concretely is tracheal stent that can be absorbed and contains drug coating, including the casing of cylindrical cylinder shape, the casing includes longitudinal skeleton, ring skeleton, the drug groove of outward expansion and assembly groove, the drug coating strip is filled in the drug groove of outward expansion, the outside of casing is pasted with the film, the film includes the shrinkage film, contact touch and closed film, the utility model discloses through the degradation of closed film in patient trachea first, releases the stress on the corresponding casing at the drug groove of outward expansion, makes the drug groove of outward expansion, and the outer diameter of whole tracheal stent expands along with it, and drives drug coating strip synchronous expansion and presses outward and expands the patient place, realizes that the stent can be in the patient's body self -degradation, and the expansion force of stent can be slowly released in the process of degradation, thereby offset the stent wall thinning after degradation or the trachea natural growth leads to the stent expansion force reduction, dynamically maintained the expansion force of stent, increased the stability of stent.

The invention relates to the technical field of tablet preparation, in particular to a drug coating state detection system and method, and the system comprises a surface pretreatment module, a coating execution module, an online monitoring module, a data processing module and a control module. The pretreatment module is used for removing pollutants through plasma treatment, improving activity and enhancing coating adhesive force; the coating execution module takes a fluidized bed as an environment, and realizes uniform coating in combination with a multi-channel spray gun and posture regulation and control; the on-line monitoring module synchronously collects three-dimensional morphology, spectrum and image data, interference is suppressed, and reliability is guaranteed; the data processing module calculates thickness and uniformity indexes, and associates process and quality by machine learning; and the control module dynamically adjusts the parameters by using a PID algorithm based on the quality parameters, and starts emergency processing when the parameters are abnormal. The method corresponds to the steps. According to the invention, the adhesive force and uniformity of the coating are improved, real-time monitoring and accurate regulation are realized, the quality control difficulty and cost are reduced, and the method is suitable for functional coating production of various tablets.

The pleating and folding integrated device comprises a base, a rotating disc and a plurality of pleating heads, and the base is used for clamping and fixing a balloon; the turntable is rotatably connected to the base and is used for realizing rolling, holding and folding of the balloon; the multiple pleating heads are movably installed on the rotary disc so that pleating of the balloon can be achieved. After the balloon is pleated, the balloon is directly folded, the folding effect is better, the step of transferring the balloon in the pleating and folding process is omitted, the situation that the balloon is scratched due to the fact that the balloon is transferred between different working heads can be avoided, the phenomenon that a hydrophilic coating or a medicine coating of the balloon is incomplete or falls off is prevented, and the balloon is more stable in performance. The product pleating and folding qualification rate is improved, and the operation effect is prevented from being affected.

This invention provides a drug-coated balloon catheter, its preparation method, and its application, relating to the field of medical device technology. The drug-coated balloon catheter includes a balloon catheter and a drug coating disposed on the surface of the balloon catheter; the drug coating includes an active drug and an excipient; the active drug is a flavonoid. The drug-coated balloon catheter utilizes flavonoids, which combine the advantages of low toxicity and high water solubility. While reducing the toxic side effects of the drug coating, it achieves rapid release and efficient absorption of the drug. Furthermore, through a dual mechanism of anti-proliferation and anti-inflammation, it effectively solves the problems of potential toxic side effects, limited transport efficiency, and limited functionality that may exist in existing products at high dose densities.

The present invention is related to a drug-coated covered stent the drug coated covered stent is a novel medical device designed to address Type III coronary artery perforations during percutaneous coronary intervention (PCI). This system combines a balloon-expandable stent covered with a biocompatible graft material and coated with cytotoxic drugs at its ends to prevent excess tissue growth and promote endothelialization. through a rapid exchange delivery system, the DCCS can be precisely positioned and expanded within the artery, sealing tears and promoting healing. The device's ultrathin profile and high flexibility enable navigation through tortuous vessels. Key components are a blocking balloon (201), second guidewire (203), covered stent (205), proximal and distal shafts of the delivery system (1, 2, 3, 15 4), stent (5), graft material (6), cytotoxic drug coatings (8, 9), and endothelialization (11). This innovative solution offers a promising approach to managing coronary artery perforations, potentially reducing the need for surgical interventions.

The utility model discloses a driven end holder for medicine coating balloon catheter spraying equipment, which comprises a support, a driven turntable is rotatably connected to the support, and a driving motor for driving the driven turntable to rotate is fixedly connected to one side of the outer side wall of the support. A loading plate is fixedly connected to the side, away from the driving motor, of the outer side wall of the driven rotating disc, a mounting plate is fixedly mounted on the upper surface of the loading plate, a wire winding ring is fixedly connected to the outer side wall of the mounting plate, and U-shaped wire winding storage columns which are annularly and uniformly distributed are rotationally connected to the upper surface of the wire winding ring. Through cooperation of the support, the driven rotating disc, the driving motor, the loading plate, the mounting plate, the wire coiling ring, the U-shaped wire coiling containing column, the clamping assembly and the wire lapping adjusting column, the application range of the device is effectively widened, balloon catheters of different specifications can be rapidly replaced and sprayed, and the overall spraying efficiency of the device is effectively guaranteed.

The invention discloses an intervention device for releasing medicine, which is characterized in that a stent is of a hollow cylindrical structure capable of shrinking along the radial direction of the stent, and the stent is made of a medical material with a shape memory characteristic; the drug coating is coated on the outer side of the stent; the number of the annular air bags is two, the two ends of the support are each provided with one annular air bag along the edge of the end face, the inner diameter of each annular air bag in the initial state is matched with the outer diameter of the unfolded support, a plurality of hoses are arranged between the two annular air bags in the axial direction of the support, the hoses are arranged in the support, and the two ends of each hose are communicated with the corresponding annular air bags. The inflation inlet is formed in the side wall of one annular air bag, and a check valve assembly is arranged at the inflation inlet. The outer ring of the filled and expanded annular air bag can be tightly attached to the inner wall of the blood vessel, blood is prevented from entering the attached area of the medicine coating and the inner wall of the blood vessel, the amount of medicine washed away by the blood flow is reduced, and the release period of the medicine is prolonged.

The present invention relates to a coating material for drug-coated balloons, drug-coated balloons, and a coating solution for drug-coated balloons, as well as their preparation and application. The coating solution comprises an aqueous solvent and a plurality of core-shell structures dispersed in the aqueous solvent, each of which comprises a lipid bilayer coated with a drug. The core of the core-shell structure contains a plurality of drug-loaded particles, and the shell of the core-shell structure is a lipid bilayer with an outer hydrophilic group and an inner hydrophobic group. The drug-loaded particles comprise a plurality of drug-loaded nanocrystalline particles. The combination of nanocrystals and liposomes combines the advantages of these two types of drug carriers. The resulting lipid bilayer improves the solubility of poorly soluble drugs in drug-coated balloons, resulting in a high drug loading capacity, high drug carrier stability, and stable drug crystal form, allowing for controllable drug release rates.

The utility model belongs to the field of drug delivery, and particularly relates to a drug balloon catheter. The utility model provides a medicine balloon catheter. The medicine balloon catheter comprises a balloon catheter body, a medicine storage layer and a medicine coating, wherein the outer surface of the balloon catheter body is sequentially coated with the medicine storage layer and the medicine coating. The medicine storage layer comprises one or more layers; when the drug balloon catheter is used for delivery, drugs on the outermost layer enter blood vessels preferentially and are continuously absorbed and metabolized and eliminated along with the half-life period and elimination kinetics of the drugs, and the anti-proliferation effect of the drugs is achieved. The first layer of the microspheres in the storage layer preferentially enters tissues and reaches saturation concentration, so that most of the microspheres are attached to the blood vessel wall, the modification of chitosan increases the contact between the PLGA microspheres and the blood vessel wall, a large amount of medicine is released after the structure of the storage layer collapses, and the released large amount of medicine enters the blood vessel to play a role.

A cobalt-chromium alloy stent comprising several main body units, wherein each main body unit is composed of several supporting rings connected by flexible ribs and the adjacent main body units are connected by several connecting ribs. A drug eluting stent comprising the cobalt-chromium alloy stent and a drug coating containing arsenic trioxide and tacrolimus. The drug release curves of the two composite drugs of arsenic trioxide and tacrolimus used in the present invention are adjusted, so that the inflammatory response of vascular endothelial cells and the proliferation behavior of vascular smooth muscle cells are effectively inhibited, and the vascular restenosis rate is reduced.

Described herein are shock wave catheters and methods of use thereof for delivering an active agent of a drug to the CNS via a body lumen or cavity, such as sinonasal cavity, which can bypass the blood-brain barrier (BBB). The catheters described herein can be advanced through an intranasal passage to the nasal cavity such that at least a portion of the enclosure is disposed in the nasal cavity. The enclosure can be coated with a drug coating. The method can include filling the enclosure with a conductive fluid. At least one shock wave can be generated at a shock wave emitter of the catheter disposed within the enclosure. The at least one shock wave can cause a therapeutically effective amount of the active agent of the drug coating to be delivered to the CNS via tissue of the nasal cavity, in turn, treating central nervous system diseases.

The present invention relates to a method (100) for preparing a transdermal patch (200). The method (100) achieves an accurate dosing of the drug, an accurate dispensing location, and an average distribution of the drug coating in the transdermal patch (200). The method (100) excludes heating and drying steps generally used in conventional transdermal patch preparation methods in order to maintain the quality of the drug in the transdermal patch (200). The invention also relates to said transdermal patch (200) for use in the treatment of wounds or scars, wherein said transdermal patch (200) comprises a backing film (220), a film layer (240) coated with said medicament, an adhesive layer (260) and a release liner (280). Preferably, the drug in the transdermal patch (200) comprises a synthetic formulation or a natural formulation with biological properties, depending on the desired treatment.

The invention discloses a composite medicine coating for treating pulmonary arterial hypertension, and belongs to the technical field of medical instruments. The coating is composed of an inert protective layer and a composite drug coating, the inert protective layer is a polyamino acid polymer, responds to pH change and is rapidly disintegrated only in the pH environment of a target site, and the loss of the composite drug coating in the delivery process is reduced; the composite drug coating is a composite component containing two or more gene regulatory factors and / or drugs, achieves a synergistic effect through a signal path, cells and a gene level, more efficiently regulates pulmonary artery endothelial cell dysfunction and smooth muscle cell injury, and has precise targeting and irreplaceability.

The invention discloses methacrylic acid-acrylate copolymer latex for an enteric coating material and a preparation method of the methacrylic acid-acrylate copolymer latex. The emulsifier-free methacrylic acid-acrylate copolymer latex enteric drug coating material is prepared by using an amphiphilic macromolecular reversible addition chain scission chain transfer reagent (RAFT reagent) in combination with an emulsion polymerization method (RAFT emulsion polymerization method). The innovation point of the invention is that the methacrylic acid-acrylate copolymer latex enteric coating material without the emulsifier can be prepared by the RAFT emulsion polymerization method, the polymer generated in the polymerization process is reduced, the use of the emulsifier harmful to health is avoided, the efficiency of the polymer latex in the process of removing the unreacted monomer in vacuum can be improved, and the preparation process is simple. The protection on the enteric-coated medicine is more effective.

This invention provides a temperature-sensitive, environmentally friendly microcapsule and its preparation method, relating to the field of polymer materials. The microcapsule is composed of chitosan, cellulose derivatives, gelatin, and dopamine. The microcapsule can achieve different cross-linking structures depending on the component ratios, and can controllably release the core substance within a temperature range of 90-150℃. The materials provided by this invention eliminate toxic reagents, and the microcapsules are all environmentally friendly materials, causing no environmental pollution. The microcapsule preparation method is characterized by temperature sensitivity and controllability, being green, environmentally friendly, and pollution-free, with a simple preparation method suitable for large-scale industrial production. Utilizing temperature-sensitive, biodegradable, and comprehensively environmentally friendly materials, it has broad application prospects in catalyst coating, drug coating, and other fields, meeting the needs of multiple sectors.

A non-occluding drug-coated balloon catheter device for use in a blood vessel transporting blood comprises a catheter shaft including a guidewire lumen, a fluid lumen and a connector port. A balloon is mounted on the catheter shaft and includes an outer envelope surrounding the guidewire lumen in fluid communication with the fluid lumen; a drug coating applied on the exterior surface of the outer envelope; and at least one bypass lumen forming a passage extending from the proximal end of the outer envelope to the distal end of the outer envelope. When the balloon is positioned in a blood vessel and inflated, the exterior surface of the outer envelope presses the drug coating against the blood vessel and the bypass lumen is open between the distal end of the outer envelope and the proximal end of the outer envelope such that blood transport continues through the bypass lumen.

The present application belongs to the technical field of medical devices, and particularly relates to a vascular stent and a preparation method thereof. The preparation method comprises the following steps: firstly, placing a base body of the vascular stent on a rotatable fixing device and immersing an outer surface of the base body into a coating solution; secondly, rotating the base body along with the fixing device around a central axis of the fixing device to perform coating; and thirdly, drying the vascular stent with a coating layer formed on the surface after the base body stops coating. The preparation method of the drug coating of the vascular stent has the advantages of no film formation on the surface of the vascular stent during coating, simple coating operation, easy industrialization and the like. The vascular stent prepared by the method has the advantages of single-side coating and uniform coating of the coating layer.

The present invention provides a drug coating, and a medical device, system, and method for manufacturing the drug coating. The drug coating comprises a non-degradable fluoropolymer matrix and a drug dispersed therein, and has inner and outer layers with different drug concentrations along the thickness direction of the drug coating, the drug concentration of the inner layer being 10 wt% or more by weight, the drug concentration of the outer layer being less than 10 wt% by weight, and the thickness of the outer layer being 20 μm or less. The drug coating of the present invention can stably release the drug to the tissue wall in contact with it over a long period of time in order to achieve long-term therapeutic or preventive effects against diseases such as luminal stenosis.

The invention relates to the technical field of capsule preparations, in particular to a medicinal capsule structure, which comprises a mother capsule and a sub-capsule filled in the mother capsule, and two working modes are realized through filling switching of the mother capsule: under the mode A (time sequence release), the mother capsule is filled with a quick-release medicine and the sub-capsule filled with a slow-release medicine at the same time, and under the mode B (time sequence release), the sub-capsule is filled with a slow-release medicine; multi-component off-peak release is realized by utilizing the quick release characteristic of the mother capsule and the slow release characteristic of the ascomycetes; and in the mode B (split swallowing), the mother capsule is only filled with the ascoid to adapt to people with dysphagia, and the ascoid can be taken in a mixed manner after the mother capsule is split, and the function of a medicine coating is reserved. The ascus is composed of a medicine containing cavity, a targeting layer and an anchoring layer, the targeting layer can be made of an arabinoxylan-chitosan compound (colon targeting) or a methacrylic acid copolymer (esophageal targeting), the anchoring layer is made of a hyaluronic acid-chitosan compound, and it is ensured that the ascus is anchored at the focus position. The preparation has multiple functions of sequential release, targeted drug delivery, adaptation to people with dysphagia and the like.

The application discloses a shock wave balloon catheter and belongs to the technical field of medical devices, which comprises a tube body, a balloon arranged on the outer wall of the tube body, at least one shock wave generator arranged in the balloon, and a convex device arranged on the outer surface of the balloon, wherein the convex device and the outer surface of the balloon are provided with a drug coating, at least one liquid injection cavity and a guide wire cavity are arranged in the tube body, and the liquid injection cavity is communicated with the balloon; the application integrates multi-form mechanical convex devices on the surface of the balloon, and coats anti-proliferation drugs on the surface of the convex device and the balloon, so that the trinity treatment of mechanical cutting / piercing, shock wave and drug elution is realized, the three functions of mechanical fragmentation of calcification / fibrosis lesions, shock wave deep lysis of calcified substances and local drug delivery are simultaneously achieved by the same instrument, one-time comprehensive treatment of complex vascular lesions is realized, and instrument replacement is avoided.

A medical device may be coated with a therapeutic composition comprising a direct oral anticoagulant. An exemplary drug coating composition may include an excipient including polylactic acid (PLA), poly (lactic acid-co-glycolic acid) (PLGA), or poly (vinylidene fluoride-co-hexafluoropropylene (PVDF-HFP), and a direct oral anticoagulant (DOAC). An exemplary pharmaceutical coating may be applied to an exterior surface of a medical device.

The invention discloses a drug coating state online monitoring method and device, and the method comprises the steps: employing an optical fiber femtosecond laser as a light source core, and transmitting femtosecond laser for detection; a terahertz time-domain spectrometer is adopted as a detection instrument, and a terahertz probe of the spectrometer is fixed to the outer side of a mesh of a to-be-detected sample coating pan; the time delay of the probe light emitted by the fiber femtosecond laser is adjusted by controlling the fiber time delay line, and the signal emission and reception of the terahertz probe are synchronously controlled; the terahertz probe transmits a signal to a to-be-detected sample and converts a received terahertz return signal into an electric signal, and the electric signal is amplified by the lock-in amplifier and then transmitted to the terminal equipment; and the terminal equipment generates terahertz time-domain spectroscopic data according to the received signal, and calculates the coating thickness of the to-be-detected sample. The method and the device can solve the problems that the measurement result is lagged and the coating thickness distribution state and the uniformity cannot be detected in real time in the prior art.

Profiled drug-coated balloons for nanoparticle-based drug delivery having a reduced-diameter central balloon portion and methods of drug delivery using same are disclosed. The profiled drug-coated balloon may comprise: distal and proximal balloon end portions having a first nominal full inflation diameter; a central balloon portion between said end portions, the central balloon portion having a second, lesser nominal full inflation diameter; a drug carrying nanoparticle coating on said central balloon portion.