72 results about "Drug coating" patented technology

Covered stents may be coated with or otherwise include a drug eluting composition. An illustrative stent may comprise an elongated tubular body having a strut framework defining a plurality of open cells. A polymeric coating may be disposed on a surface of the elongated tubular body and extending across the plurality of open cells and a first drug coating composition disposed on a surface of the polymeric coating.

The invention relates to the technical field of medical instruments, in particular to a paclitaxel drug coating balloon dilatation catheter and a preparation method and application thereof.The paclitaxel drug coating comprises a substrate layer, a middle layer and an outer layer; the substrate layer comprises paclitaxel and a hydrophilic excipient; the middle layer comprises a lipophilic excipient and a temperature response type polymer; and the outer layer comprises a pH sensitive polymer. The substrate layer is combined with the surface of the balloon, so that excellent conveying stability is provided, the medicine is effectively prevented from falling off prematurely in the conveying process of the catheter, and the firmness of the coating is improved; a micropore network structure is formed in the middle layer, the network structure is expanded under the body temperature condition, the porosity is increased, slow release of the medicine is achieved, the absorption amount of the medicine on the blood vessel wall is effectively increased, and the medicine effect time is prolonged; the solubility of the outer layer is improved in a slightly acidic blood vessel wall environment, so that the release of the medicine is further promoted, and the effective release of the medicine on the blood vessel wall is ensured.

This invention relates to the field of tablet preparation technology, specifically to a drug coating state detection system and method. The system includes a surface pretreatment module, a coating execution module, an online monitoring module, a data processing module, and a control module. The pretreatment module removes contaminants and enhances activity through plasma treatment, thereby improving coating adhesion. The coating execution module uses a fluidized bed environment, combined with a multi-channel spray gun and attitude control, to achieve uniform coating. The online monitoring module simultaneously acquires three-dimensional morphology, spectral, and image data, suppressing interference to ensure reliability. The data processing module calculates thickness and uniformity indicators, using machine learning to correlate process and quality. The control module dynamically adjusts parameters based on quality parameters using a PID algorithm, initiating emergency handling in case of anomalies. The method corresponds to the above steps. This invention improves coating adhesion and uniformity, achieves real-time monitoring and precise control, reduces the difficulty and cost of quality control, and is applicable to the production of various functional tablet coatings.

The invention provides a pressure adjusting system and a method for adjusting the pressure of fluid in an inner cavity of medical equipment, and relates to a method for controlling a pressure control pump to enable the pressure of the fluid in the inner cavity of the medical equipment to change within a period of time. A coronary artery blood vessel remodeling catheter, a peripheral balloon dilatation catheter, a peripheral blood vessel remodeling catheter, an intracranial laser balloon dilatation catheter, a drug coating balloon dilatation catheter, a photodynamic balloon catheter, a mastoid balloon catheter, a constraint type balloon dilatation catheter and a spinous process balloon can be made. Expansion and contraction of a balloon body in a balloon catheter such as a drug delivery balloon catheter are regularly changed within a period of time, and therefore the treatment effect is better achieved.

The utility model relates to medical instrument technical field, concretely is tracheal stent that can be absorbed and contains drug coating, including the casing of cylindrical cylinder shape, the casing includes longitudinal skeleton, ring skeleton, the drug groove of outward expansion and assembly groove, the drug coating strip is filled in the drug groove of outward expansion, the outside of casing is pasted with the film, the film includes the shrinkage film, contact touch and closed film, the utility model discloses through the degradation of closed film in patient trachea first, releases the stress on the corresponding casing at the drug groove of outward expansion, makes the drug groove of outward expansion, and the outer diameter of whole tracheal stent expands along with it, and drives drug coating strip synchronous expansion and presses outward and expands the patient place, realizes that the stent can be in the patient's body self -degradation, and the expansion force of stent can be slowly released in the process of degradation, thereby offset the stent wall thinning after degradation or the trachea natural growth leads to the stent expansion force reduction, dynamically maintained the expansion force of stent, increased the stability of stent.

The pleating and folding integrated device comprises a base, a rotating disc and a plurality of pleating heads, and the base is used for clamping and fixing a balloon; the turntable is rotatably connected to the base and is used for realizing rolling, holding and folding of the balloon; the multiple pleating heads are movably installed on the rotary disc so that pleating of the balloon can be achieved. After the balloon is pleated, the balloon is directly folded, the folding effect is better, the step of transferring the balloon in the pleating and folding process is omitted, the situation that the balloon is scratched due to the fact that the balloon is transferred between different working heads can be avoided, the phenomenon that a hydrophilic coating or a medicine coating of the balloon is incomplete or falls off is prevented, and the balloon is more stable in performance. The product pleating and folding qualification rate is improved, and the operation effect is prevented from being affected.

This invention provides a drug-coated balloon catheter, its preparation method, and its application, relating to the field of medical device technology. The drug-coated balloon catheter includes a balloon catheter and a drug coating disposed on the surface of the balloon catheter; the drug coating includes an active drug and an excipient; the active drug is a flavonoid. The drug-coated balloon catheter utilizes flavonoids, which combine the advantages of low toxicity and high water solubility. While reducing the toxic side effects of the drug coating, it achieves rapid release and efficient absorption of the drug. Furthermore, through a dual mechanism of anti-proliferation and anti-inflammation, it effectively solves the problems of potential toxic side effects, limited transport efficiency, and limited functionality that may exist in existing products at high dose densities.

The utility model discloses a driven end holder for medicine coating balloon catheter spraying equipment, which comprises a support, a driven turntable is rotatably connected to the support, and a driving motor for driving the driven turntable to rotate is fixedly connected to one side of the outer side wall of the support. A loading plate is fixedly connected to the side, away from the driving motor, of the outer side wall of the driven rotating disc, a mounting plate is fixedly mounted on the upper surface of the loading plate, a wire winding ring is fixedly connected to the outer side wall of the mounting plate, and U-shaped wire winding storage columns which are annularly and uniformly distributed are rotationally connected to the upper surface of the wire winding ring. Through cooperation of the support, the driven rotating disc, the driving motor, the loading plate, the mounting plate, the wire coiling ring, the U-shaped wire coiling containing column, the clamping assembly and the wire lapping adjusting column, the application range of the device is effectively widened, balloon catheters of different specifications can be rapidly replaced and sprayed, and the overall spraying efficiency of the device is effectively guaranteed.

The invention discloses an intervention device for releasing medicine, which is characterized in that a stent is of a hollow cylindrical structure capable of shrinking along the radial direction of the stent, and the stent is made of a medical material with a shape memory characteristic; the drug coating is coated on the outer side of the stent; the number of the annular air bags is two, the two ends of the support are each provided with one annular air bag along the edge of the end face, the inner diameter of each annular air bag in the initial state is matched with the outer diameter of the unfolded support, a plurality of hoses are arranged between the two annular air bags in the axial direction of the support, the hoses are arranged in the support, and the two ends of each hose are communicated with the corresponding annular air bags. The inflation inlet is formed in the side wall of one annular air bag, and a check valve assembly is arranged at the inflation inlet. The outer ring of the filled and expanded annular air bag can be tightly attached to the inner wall of the blood vessel, blood is prevented from entering the attached area of the medicine coating and the inner wall of the blood vessel, the amount of medicine washed away by the blood flow is reduced, and the release period of the medicine is prolonged.

The invention discloses a composite medicine coating for treating pulmonary arterial hypertension, and belongs to the technical field of medical instruments. The coating is composed of an inert protective layer and a composite drug coating, the inert protective layer is a polyamino acid polymer, responds to pH change and is rapidly disintegrated only in the pH environment of a target site, and the loss of the composite drug coating in the delivery process is reduced; the composite drug coating is a composite component containing two or more gene regulatory factors and / or drugs, achieves a synergistic effect through a signal path, cells and a gene level, more efficiently regulates pulmonary artery endothelial cell dysfunction and smooth muscle cell injury, and has precise targeting and irreplaceability.

This invention provides a temperature-sensitive, environmentally friendly microcapsule and its preparation method, relating to the field of polymer materials. The microcapsule is composed of chitosan, cellulose derivatives, gelatin, and dopamine. The microcapsule can achieve different cross-linking structures depending on the component ratios, and can controllably release the core substance within a temperature range of 90-150℃. The materials provided by this invention eliminate toxic reagents, and the microcapsules are all environmentally friendly materials, causing no environmental pollution. The microcapsule preparation method is characterized by temperature sensitivity and controllability, being green, environmentally friendly, and pollution-free, with a simple preparation method suitable for large-scale industrial production. Utilizing temperature-sensitive, biodegradable, and comprehensively environmentally friendly materials, it has broad application prospects in catalyst coating, drug coating, and other fields, meeting the needs of multiple sectors.

The present invention provides a drug coating, and a medical device, system, and method for manufacturing the drug coating. The drug coating comprises a non-degradable fluoropolymer matrix and a drug dispersed therein, and has inner and outer layers with different drug concentrations along the thickness direction of the drug coating, the drug concentration of the inner layer being 10 wt% or more by weight, the drug concentration of the outer layer being less than 10 wt% by weight, and the thickness of the outer layer being 20 μm or less. The drug coating of the present invention can stably release the drug to the tissue wall in contact with it over a long period of time in order to achieve long-term therapeutic or preventive effects against diseases such as luminal stenosis.

The invention relates to the technical field of capsule preparations, in particular to a medicinal capsule structure, which comprises a mother capsule and a sub-capsule filled in the mother capsule, and two working modes are realized through filling switching of the mother capsule: under the mode A (time sequence release), the mother capsule is filled with a quick-release medicine and the sub-capsule filled with a slow-release medicine at the same time, and under the mode B (time sequence release), the sub-capsule is filled with a slow-release medicine; multi-component off-peak release is realized by utilizing the quick release characteristic of the mother capsule and the slow release characteristic of the ascomycetes; and in the mode B (split swallowing), the mother capsule is only filled with the ascoid to adapt to people with dysphagia, and the ascoid can be taken in a mixed manner after the mother capsule is split, and the function of a medicine coating is reserved. The ascus is composed of a medicine containing cavity, a targeting layer and an anchoring layer, the targeting layer can be made of an arabinoxylan-chitosan compound (colon targeting) or a methacrylic acid copolymer (esophageal targeting), the anchoring layer is made of a hyaluronic acid-chitosan compound, and it is ensured that the ascus is anchored at the focus position. The preparation has multiple functions of sequential release, targeted drug delivery, adaptation to people with dysphagia and the like.

A medical device may be coated with a therapeutic composition comprising a direct oral anticoagulant. An exemplary drug coating composition may include an excipient including polylactic acid (PLA), poly (lactic acid-co-glycolic acid) (PLGA), or poly (vinylidene fluoride-co-hexafluoropropylene (PVDF-HFP), and a direct oral anticoagulant (DOAC). An exemplary pharmaceutical coating may be applied to an exterior surface of a medical device.

The invention discloses a drug coating state online monitoring method and device, and the method comprises the steps: employing an optical fiber femtosecond laser as a light source core, and transmitting femtosecond laser for detection; a terahertz time-domain spectrometer is adopted as a detection instrument, and a terahertz probe of the spectrometer is fixed to the outer side of a mesh of a to-be-detected sample coating pan; the time delay of the probe light emitted by the fiber femtosecond laser is adjusted by controlling the fiber time delay line, and the signal emission and reception of the terahertz probe are synchronously controlled; the terahertz probe transmits a signal to a to-be-detected sample and converts a received terahertz return signal into an electric signal, and the electric signal is amplified by the lock-in amplifier and then transmitted to the terminal equipment; and the terminal equipment generates terahertz time-domain spectroscopic data according to the received signal, and calculates the coating thickness of the to-be-detected sample. The method and the device can solve the problems that the measurement result is lagged and the coating thickness distribution state and the uniformity cannot be detected in real time in the prior art.

The invention relates to the technical field of medical instruments, and provides a side branch protection balloon catheter for bifurcation lesion interventional therapy, and the side branch protection balloon catheter for bifurcation lesion interventional therapy according to the embodiment of the invention comprises an outer tube, a main branch balloon, a side branch balloon, a constraint structure and a drug coating, the main branch balloon is connected with the far end of the outer tube through a first tube pin; the side branch balloon is connected with the far end of the outer tube through a second tube pin; the restraint structure is used for connecting the near end of the main branch balloon and the second pin, and at least one of the surface of the main branch balloon and the surface of the side branch balloon is coated with the medicine coating. The restraint structure is connected with the near end of the main branch balloon and the second pin, the double-balloon cooperative positioning structure is matched, smoothness of side branch blood vessels is guaranteed while main branch blood vessels are expanded, the problem that positioning of the main branch balloon and the side branch blood vessels is difficult is effectively solved, and the positioning accuracy of the main branch blood vessels and the side branch blood vessels is improved. The method has the advantages that the cooperative positioning precision of the main branch and side branch balloons is improved, and the surgical risk is reduced.

Provided are a medicament-coated balloon coating solution, a coating material, a medicament-coated balloon, a preparation method therefor, and use thereof. The medicament-coated balloon coating solution comprises an aqueous-phase solvent. The coating solution further comprises a plurality of core-shell structures formed by wrapping a medicament in a phospholipid bilayer. The core-shell structures are dispersed in the aqueous-phase solvent. A core of each core-shell structure comprises a plurality of particles loaded with the medicament. A shell of each core-shell structure is the phospholipid bilayer. The phospholipid bilayer comprises a hydrophilic group in an outer layer and a hydrophobic group in an inner layer. The plurality of particles loaded with the medicament comprise a plurality of nanocrystalline particles comprising the medicament. Nanocrystalline is combined with liposome, such that advantages of two types of medicament carriers are combined. The formed phospholipid bilayer increases the solubility of a poorly soluble medicament on the medicament-coated balloon, the medicament loading capacity is high, the stability of the medicament carriers is good, and the medicament crystal form is stable, such that the medicament release rate is controllable.

A metal medicine expansion balloon without blocking blood flow comprises an adjustable inner conveying system and a screw-in type outer conveying system, the adjustable inner conveying system is formed by connecting a supporting balloon with an adjustable handle through an inner pushing rod, the screw-in type outer conveying system is arranged on the periphery of the adjustable inner conveying system, and the screw-in type outer conveying system is connected with the adjustable handle through an outer pushing rod. Comprising a covered stent, a drug coating film, a main body skeleton, an outer pushing rod and a screw-in valve, the drug coating film covers the main body skeleton through the covered stent, the near end of the covered stent is connected with the far end of the outer pushing rod, and the near end of the outer pushing rod is connected with the far end of the screw-in valve. The internal system and the external system work cooperatively, a multi-channel blood flow path is formed during expansion, intraoperative blood perfusion is kept, acute ischemia and thrombosis risks during the operation are reduced, the internal supporting balloon adopts a shape memory alloy weaving process, pressure feedback in the expansion process is more obvious, the adherence gap is smaller, the adherence process is conformal, and the system is more suitable for complex lesions; meanwhile, the cutting effect is achieved, and the expansion effect is effectively improved.

The present application relates to a kind of microneedle transdermal drug delivery technology, in particular, it relates to a kind of drug-loaded table transdermal nursing system.The drug-loaded table transdermal nursing system includes penetration device, penetration device includes penetration unit, and the penetration unit has substrate and the penetration micro-unit formed on substrate;It further includes delivery device;Delivery device includes delivery unit, and the delivery unit has drug-loading platform, and drug-loading surface of drug-loading platform is provided with drug coating, and drug coating has water-soluble and contains active ingredient;Delivery device can be delivered active ingredient by the reciprocating touch of the skin of specific area multiple times, and when the skin of specific area is touched each time, drug coating partially dissolves, and when the number of touch reaches specific number, drug coating completely dissolves.The nursing system is simple and convenient to operate, can realize the accurate, stable control of drug dosage, can be implemented uniform nursing to specific skin area, and can be suspended or discontinued at any time.

This invention relates to a drug delivery method for a membrane-covered stent, comprising the following steps: 1) preparing a coating solution and atomizing it; 2) applying a drug coating to the stent and drying it; 3) covering the stent surface with a thin film; 4) preparing a coating solution, atomizing the membrane-covered stent, and applying the coating solution to the surface of the membrane-covered stent; 5) atomizing the membrane-covered stent with a solvent and drying it. The beneficial effects of this invention are that the design of the inner and outer drug coatings on the stent and the membrane surface can flexibly achieve multifunctional composite effects according to different drug delivery purposes, drug delivery sites, and drug delivery methods, and the inner and outer drug coatings do not affect each other, with controllable drug release rates, achieving the purpose of preventing restenosis and reducing thrombus formation.

The invention belongs to the technical field of medical compositions, and discloses a medicine coating for a prepuce cutting suturing nail and the prepuce cutting suturing nail containing the medicine coating. The quaternary ammonium salt-73 in the medicine coating has good sterilization and anti-inflammation effects and is high in biocompatibility; paclitaxel can inhibit wall-climbing hyperplasia of cells at the wound, so that the problem that a suturing nail cannot be automatically disengaged due to the fact that the suturing nail is wrapped by hyperplasia tissue is solved; besides, chitosan has the characteristic of biodegradability, after suturing of the suturing nail, the coating is thinned or disappears, the gap between the suturing nail and the foreskin tissue can be enlarged, and therefore the suturing nail is loosened, the surface is smoother due to the existence of the medicine coating, and automatic falling of the suturing nail is facilitated. The raw materials used by the medicine coating are biocompatible and friendly materials, rejection caused by poor biocompatibility of the material of a traditional suturing nail can be reduced, inflammation is reduced, and under the action of the coating medicine, it is guaranteed that a wound is not prone to inflammation and can be healed faster.

The invention provides a drug loading device capable of achieving continuous perfusion, the drug loading device comprises a balloon dilatation catheter, a drug covered stent and a guide recovery catheter which are connected in sequence, the drug covered stent comprises a self-expanding base stent, a balloon assembly is arranged in the base stent, a covering film is arranged on the surface of the base stent, and the balloon assembly is connected with the guide recovery catheter. A medicine coating is arranged on the surface of the covering film, the base body support comprises a main body section capable of expanding in the radial direction, the two ends of the main body section are connected with fixing sections through connecting sections, and the balloon assembly is arranged in the main body section and fixed through the fixing sections. According to the embodiment of the invention, the medicine placement time can be prolonged, so that the medicine is better absorbed; meanwhile, the medicine loss of the medicine in the release process can be reduced, the harm of the medicine to other visceral organs due to the blood flow flushing effect is reduced, and the transfer rate of the medicine to blood vessels is increased; and as the placement time can be prolonged, the device can be used as a treatment device for vascular perforation.

The invention relates to the technical field of medical instruments, and discloses an intravascular anti-endothelialization recoverable stent electrode for a brain-computer interface. The device comprises a support part, a recovery hook part and a transition part for connecting the support part and the recovery hook part. The supporting part is composed of a long and thin rib-shaped structure with shape memory and can be automatically opened and fixed after being implanted into a blood vessel. A flexible film electrode is attached to the rib-shaped structure, and conductive contacts connected in series are arranged on the electrode and used for being in contact with the blood vessel wall to input / output electric signals. The key improvement is that a spiral groove is formed in the tube wall of the recovery hook part and can be matched with a special recovery instrument to realize minimally invasive recovery in and after an operation; meanwhile, the outer surface of the stent electrode is coated with an anti-thrombus and endothelialization inhibiting drug coating, so that the smoothness of blood vessels and the long-term function of the electrode can be effectively maintained. The technical problem that an existing intravascular electrode cannot be recycled and is prone to being wrapped by endothelial tissue to cause failure is solved, and treatment safety and flexibility are improved.

The invention provides a verapamil hydrochloride sustained-release capsule with stable release rate during storage, the sustained-release capsule content comprises a sustained-release coated pellet, and the sustained-release coated pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer; the drug coating layer comprises verapamil hydrochloride and a release stabilizer, and the in-vitro release degree similarity factor f2 of the sustained-release capsule after being placed for a long time under the conditions of 40 DEG C and RH of 75% and the sustained-release capsule before being placed is greater than 50. The verapamil hydrochloride sustained-release capsule effectively solves the problem that the in-vitro release degree is unstable in the storage process of the verapamil hydrochloride sustained-release capsule, and the clinical medication safety of the preparation within the storage validity period is greatly improved.

The application belongs to the field of medical application, and particularly relates to an anti-skin and wound infection pathogenic bacteria polypeptide, a polypeptide solution and application. The anti-skin and wound infection pathogenic bacteria polypeptide can effectively inhibit or kill Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and the amino acid sequence of the anti-skin and wound infection pathogenic bacteria polypeptide is Phe-Leu-Lys-Lys-Ala-Ala-Lys-Lys-Leu-Leu-Lys-Lys-Leu-Phe. Meanwhile, the polypeptide has good stability and very low toxicity. The polypeptide has the potential to be developed into an antibacterial gel, a spray preparation and a drug coating with the efficacy of resisting Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and is used for preventing and treating skin and wound infections and other infectious diseases caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.

The invention discloses a degradable metal stent with a medicine storage cavity and a manufacturing method of the degradable metal stent, and relates to the technical field of medical instrument manufacturing. The inner-layer bracket and the outer-layer bracket are of hollow structures; the non-hollow parts of the inner-layer stent and the outer-layer stent are consistent in shape and are aligned and attached to each other; medicine storage grooves are distributed in a non-hollow part of the inner-layer bracket; the inner-layer stent and the outer-layer stent are both degradable metal stents. According to the invention, the drug coating on the outer layer of the stent releases the drug for early treatment, and the degradation speed of the outer-layer stent is higher than that of the inner-layer stent, so that the outer-layer stent can be degraded and disappear before the inner-layer stent, the drug storage groove on the inner-layer stent is exposed, and the drug is released again for treatment; therefore, long-time-span drug treatment can be conveniently achieved, and the problem that treatment is not convenient when plaques become large or blood vessels are blocked in the later period of the blood vessels is effectively solved.

A drug coating delivery device includes a delivery device body, a balloon is arranged on the delivery device body, a drug coating is coated on the surface of the balloon, a drug coating solution is mixed by an anti-proliferative drug, an excipient, a stabilizer and a crystallization solvent, the drug coating is coated on the surface of the balloon by a drug coating method, the drug coating method includes clamping, inflating, primer coating, hair throwing, segmented coating, installing a protective sleeve, drying, the drug coating delivery device prepared by the different coating method has higher drug coating firmness than the drug coating delivery device prepared by the traditional coating method, thus, drug loss in the delivery process can be greatly reduced, more drugs can be delivered to the target diseased blood vessels, drug utilization rate and clinical use effect are improved.

The present disclosure provides methods of preparing pharmaceutical formulations containing dapagliflozin and uses thereof. The method for preparing the dapagliflozin-containing pharmaceutical preparation comprises the following steps: dissolving dapagliflozin and / or a hydrate thereof and lactose in an aqueous solution of alcohol and / or ketone to ensure that the mass ratio of the dissolved lactose to the dapagliflozin is (1-9.4): 1 to obtain a coating solution; and preparing an upper drug coating layer by using the coating liquid. Therefore, the dissolution stability of dapagliflozin in the pharmaceutical preparation in the storage process can be improved.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

The invention discloses a valve clamping device and a preparation method thereof, the valve clamping device is made of a degradable high polymer material doped with a developing component, and the surface of the valve clamping device is covered with a degradable drug coating. The valve clamping device is safe and non-toxic, can be degraded into water and carbon dioxide in vivo, and has small burden on body organs. The surface of the valve clamping device is coated with a degradable medicine coating, and the risk of causing inflammation, tissue hyperplasia and thrombus after the valve clamping device is implanted into a human body is low. Due to the introduction of the developing component, the valve clamping device can be positioned in vivo in real time by virtue of developing equipment, so that a replacement operation of the valve clamping device can be conveniently carried out as required under specific conditions, such as when the valve clamping device is not completely degraded.