187 results about "Drug coating" patented technology

Methods of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject, methods of treating chronic rhinosinusitis (CRS) or chronic rhinosinusitis with nasal polyps (CRSwNP) in a human subject, methods of treating a eustachian tube disorder in a human subject, and devices and systems for performing the methods. A method of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject includes inserting a drug-coated balloon catheter into a target site in a trachea, mainstem bronchus, bronchus intermedius, lobar bronchus, segmental bronchus, or sub-segmental bronchus, wherein the balloon is coated with a coating layer including the therapeutic agent and one or more additives. The therapeutic agent includes paclitaxel, sirolimus, or a derivative thereof. The method includes inflating the balloon to dilate the airway and deliver a therapeutic agent to the airway wall. The method includes deflating the balloon. The method also includes withdrawing the balloon catheter from the target site.

Various embodiments disclosed relate to polymer-encapsulated drug particles and a drug-releasing coating including the same, as well as drug-coated balloon catheters for treating, preventing, or reducing the recurrence of strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes the polymer-encapsulated drug particles; or a drug-releasing coating including the polymer-encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

The invention discloses a drug eluting stent, which comprises a stent main body and a plurality of thorn-shaped components, the stent main body has a radially compressible contraction state and a radially self-expanding expansion state to support blood vessels, and the plurality of thorn-shaped components are arranged on the outer surface of the stent main body and coated with a drug coating for inhibiting vascular restenosis. The spine-shaped components are arranged on the stent body and are configured to protrude towards the outer side of the stent body from the outer surface of the stent body to penetrate into calcified lesions on the inner wall of a blood vessel when the stent body is switched from the contraction state to the expansion state, each spine-shaped component is provided with a part capable of generating elastic deformation, and the spine-shaped components are configured to be capable of generating deformation in a self-adaptive mode according to the thickness of the contacted calcified lesions. Therefore, the medicine can be uniformly distributed in a target lesion area, and the utilization rate of the medicine and the treatment effect are remarkably improved.

Described herein are shock wave catheters and methods of use thereof for delivering an active agent of a drug to the CNS via a body lumen or cavity, such as sinonasal cavity, which can bypass the blood-brain barrier (BBB). The catheters described herein can be advanced through an intranasal passage to the nasal cavity such that at least a portion of the enclosure is disposed in the nasal cavity. The enclosure can be coated with a drug coating. The method can include filling the enclosure with a conductive fluid. At least one shock wave can be generated at a shock wave emitter of the catheter disposed within the enclosure. The at least one shock wave can cause a therapeutically effective amount of the active agent of the drug coating to be delivered to the CNS via tissue of the nasal cavity, in turn, treating central nervous system diseases.

The invention belongs to the technical field of medical instruments. The invention discloses a drug coating balloon catheter and a preparation method thereof. In one aspect, a drug coated balloon catheter includes a catheter with a balloon; a drug coating at least comprising an inner coating and an outer coating is arranged on the outer wall of the balloon, and the inner coating and the outer coating are provided with drug active ingredients and different carriers respectively; when the balloon is expanded, the inner coating and the outer coating are separated from the balloon through the state change of the temperature-sensitive carrier of the inner coating under the body temperature environment of a patient and the hydration effect, and the outer coating is used for promoting corresponding active pharmaceutical ingredients to be transferred into target tissues through the carrier of the outer coating when the outer coating is separated from the balloon. On the other hand, the invention provides a preparation method of the drug coating balloon catheter. The preparation method has the advantages that the adhesiveness of the drug coating on the balloon can be effectively improved so as to reduce the delivery loss, and the release rate of the drug coating on diseased tissues can be improved so as to improve the drug transfer capacity.

Covered stents may be coated with or otherwise include a drug eluting composition. An illustrative stent may comprise an elongated tubular body having a strut framework defining a plurality of open cells. A polymeric coating may be disposed on a surface of the elongated tubular body and extending across the plurality of open cells and a first drug coating composition disposed on a surface of the polymeric coating.

The invention discloses a drug eluting stent, which comprises a stent main body and a plurality of thorn-shaped components, the stent main body has a radially compressible contraction state and a radially self-expanding expansion state to support blood vessels, and the plurality of thorn-shaped components are arranged on the outer surface of the stent main body and coated with a drug coating for inhibiting vascular restenosis. The spine-shaped components protrude from the outer surface of the stent body to the outer side of the stent body so as to penetrate into calcification lesions on the inner wall of a blood vessel when the stent body is switched from the contraction state to the expansion state, each spine-shaped component comprises a spine section, and the spine section at least comprises a first section and a second section of which the roots are connected together. The first section and the second section are attached to each other in a natural state to form a compact structure, and can elastically deform and be separated relative to the root part when subjected to opposite acting force from calcification lesion, so that the calcification lesion can be punctured at a larger angle, the slippage risk is reduced, the puncturing efficiency is improved, and the puncturing effect is improved. Therefore, the effect of inhibiting vascular restenosis is enhanced.

The invention relates to the technical field of medical instruments, and discloses a drug coating balloon with a multi-layer structure and a preparation method thereof.A bottom layer of a drug coating, a drug layer and a protective layer are sequentially manufactured on the balloon from inside to outside, the balloon is in a full state when a bottom layer solution and a drug layer solution are sprayed, then the balloon is folded in a sectioning mode, and the drug coating balloon with the multi-layer structure is obtained. And spraying a protective layer solution. The outer layer is a fat-soluble protective layer, the firmness of the dried coating is high, the coating is hardly dissolved when making contact with body fluid, it is guaranteed that the coating can always cover the surface of the medicine layer in the conveying process, the medicine layer is not directly exposed to the body fluid environment, early release is avoided, and medicine conveying loss is reduced. The bottom layer is slightly soluble in water and is always attached to the surface of the balloon before and after the balloon is expanded, and extra particles are not added; the combination between the bottom layer and the medicine layer is strong before the balloon is expanded, the bottom layer is slightly soluble after the balloon is expanded and the bottom layer is in contact with body fluid, the interface combination with the medicine layer is weakened, the medicine layer falls off and is dissolved, and the treatment effect is fully released.

The invention relates to the technical field of medical instruments, in particular to an absorbable tracheal stent containing a drug coating, which comprises a cylindrical shell, the shell comprises a longitudinal skeleton, a ring-shaped skeleton, an extension drug groove and an assembly groove, and the extension drug groove is filled with a drug coating strip; a covering film is pasted on the outer portion of the shell and comprises a tightening film, a contact film and a sealing film. According to the invention, the sealing film is firstly degraded in the trachea of a patient, and the stress on the shell corresponding to the outward expanding medicine groove is released, so that the outward expanding medicine groove is expanded, the outer diameter of the whole tracheal stent is increased, and the medicine coating strip is driven to synchronously expand outwards to abut against an affected part, so that the stent can be automatically degraded in the body of the patient; and the expansion force of the stent can be slowly released in the degradation process, so that the reduction of the expansion force of the stent caused by thinning of the wall of the degraded stent or natural growth of the trachea is counteracted, the expansion force of the stent is dynamically maintained, and the stability of the stent is improved.

The invention relates to the technical field of medical instruments, in particular to a paclitaxel drug coating balloon dilatation catheter and a preparation method and application thereof.The paclitaxel drug coating comprises a substrate layer, a middle layer and an outer layer; the substrate layer comprises paclitaxel and a hydrophilic excipient; the middle layer comprises a lipophilic excipient and a temperature response type polymer; and the outer layer comprises a pH sensitive polymer. The substrate layer is combined with the surface of the balloon, so that excellent conveying stability is provided, the medicine is effectively prevented from falling off prematurely in the conveying process of the catheter, and the firmness of the coating is improved; a micropore network structure is formed in the middle layer, the network structure is expanded under the body temperature condition, the porosity is increased, slow release of the medicine is achieved, the absorption amount of the medicine on the blood vessel wall is effectively increased, and the medicine effect time is prolonged; the solubility of the outer layer is improved in a slightly acidic blood vessel wall environment, so that the release of the medicine is further promoted, and the effective release of the medicine on the blood vessel wall is ensured.

The balloon catheter comprises a catheter base, a catheter body, a balloon, an indentation wire and an elastic tube, a medicine coating is arranged on the outer surface of the balloon, the near end of the catheter body is fixed in the catheter base, the balloon is arranged on the far end side of the catheter body, the near end of the elastic tube is fixed in the catheter body, and the indentation wire is arranged on the outer surface of the balloon. The far end of the elastic tube spans the balloon and then is fixed to the far end of the catheter, the nick wire can be arranged in the elastic tube, the catheter and the catheter base in a penetrating mode, and the nick wire can move relative to the elastic tube, the catheter and the catheter base. And the balloon is fully expanded to drive the elastic tube and the nick wire to deform. Through the arrangement of the nick wire and the elastic tube, the balloon not only has the excellent blood vessel dilatation performance of a nick balloon, but also has the function of preventing blood vessel restenosis of a medicine balloon. The use of instruments is reduced, the burden of an operation patient is reduced, the operation time is shortened, and the operation safety is improved.

The invention discloses a multifunctional anti-stenosis drug-coated stent which comprises a nickel-titanium stent, the outer surface of the nickel-titanium stent is coated with a PLLA-TPU-based drug-loaded coating, and a drug-loaded film is attached to the inner surface of the nickel-titanium stent. The body of the prepared multifunctional anti-stenosis drug-coated stent is a nickel-titanium stent and has good biocompatibility, the outer surface of the stent is coated with PLLA-TPU-based drug-loaded coating suspension slurry, the stent has good degradation performance and adjustable mechanical performance, inward or outward overgrowth of tumor cells can be effectively inhibited through drug release, and the anti-stenosis drug-coated stent has good anti-stenosis effect on tumor cells. Meanwhile, the medicine carrying membrane on the inner layer of the nickel-titanium stent can effectively inhibit tumor cells and effectively prevent bile mud from being deposited, and the nickel-titanium stent can be used for treating biliary tract stenosis diseases. The invention further provides a preparation method of the multifunctional anti-stenosis drug coating stent, the stent is prepared through a liquid flame spraying technology and a lamination method, the preparation method is simple, and the preparation period is short.

The invention discloses a medical double-core-layer pressure-resistant sensing balloon and a preparation method thereof.The medical double-core-layer pressure-resistant sensing balloon comprises a balloon body connected with a catheter, the balloon body is of a double-core-layer shell layer structure, and a core layer comprises a developing and pressure sensing double-core structure; a developing agent is loaded in the inner core layer balloon, the position of the balloon is effectively displayed, it can be guaranteed that the core layer is not affected after the outer layer is damaged, the inner layer and the other core layer balloon can synchronously conduct pressure sensing, and the shell layer is a compression layer with toughness and bursting pressure and can be coated with a medicine coating. According to the medical double-core-layer high-pressure-resistant balloon provided by the invention, through the design of the internal double core layers, accurate control of pressure is effectively realized, and the problem that a developing agent leaks out of the brain after the outer layer of the balloon is broken in a trigeminal nerve minimally invasive puncture balloon compression operation is prevented; and by controlling the surface roughness of the outer layer, medicine coating can be carried out, so that vagus nerve reflex is prevented, and the problem of high risks of sudden blood pressure rise and sudden heartbeat arrest caused by compression in the operation process is solved.

This invention relates to the field of tablet preparation technology, specifically to a drug coating state detection system and method. The system includes a surface pretreatment module, a coating execution module, an online monitoring module, a data processing module, and a control module. The pretreatment module removes contaminants and enhances activity through plasma treatment, thereby improving coating adhesion. The coating execution module uses a fluidized bed environment, combined with a multi-channel spray gun and attitude control, to achieve uniform coating. The online monitoring module simultaneously acquires three-dimensional morphology, spectral, and image data, suppressing interference to ensure reliability. The data processing module calculates thickness and uniformity indicators, using machine learning to correlate process and quality. The control module dynamically adjusts parameters based on quality parameters using a PID algorithm, initiating emergency handling in case of anomalies. The method corresponds to the above steps. This invention improves coating adhesion and uniformity, achieves real-time monitoring and precise control, reduces the difficulty and cost of quality control, and is applicable to the production of various functional tablet coatings.

The invention provides a pressure adjusting system and a method for adjusting the pressure of fluid in an inner cavity of medical equipment, and relates to a method for controlling a pressure control pump to enable the pressure of the fluid in the inner cavity of the medical equipment to change within a period of time. A coronary artery blood vessel remodeling catheter, a peripheral balloon dilatation catheter, a peripheral blood vessel remodeling catheter, an intracranial laser balloon dilatation catheter, a drug coating balloon dilatation catheter, a photodynamic balloon catheter, a mastoid balloon catheter, a constraint type balloon dilatation catheter and a spinous process balloon can be made. Expansion and contraction of a balloon body in a balloon catheter such as a drug delivery balloon catheter are regularly changed within a period of time, and therefore the treatment effect is better achieved.

The invention provides a sustained-release drug stent for tracheal lesion tissues and a preparation method thereof, and belongs to the technical field of medical instruments. The stent takes a nickel-titanium alloy wire as a base material, after acid pickling, weaving and heat treatment shaping, a drug coating is loaded through multiple steps: firstly, an anti-tumor or anti-inflammatory drug is mixed with a PLGA solution to form nano-particles; then, carrying out chitosan modification and dopamine coating, so as to obtain PLGA-PDA drug carrier nanoparticles; then, nano-particles are sprayed on the surface of the stent to form a drug coating; and finally, coating a PLGA-HA composite solution to enhance the performance of the stent. By optimizing the material and the coating structure, accurate slow release of the medicine is achieved, relapse and restenosis of tracheal lesion tissue are effectively inhibited, the treatment effect and safety are improved, and a new scheme is provided for tracheal lesion treatment.

The utility model relates to medical instrument technical field, concretely is tracheal stent that can be absorbed and contains drug coating, including the casing of cylindrical cylinder shape, the casing includes longitudinal skeleton, ring skeleton, the drug groove of outward expansion and assembly groove, the drug coating strip is filled in the drug groove of outward expansion, the outside of casing is pasted with the film, the film includes the shrinkage film, contact touch and closed film, the utility model discloses through the degradation of closed film in patient trachea first, releases the stress on the corresponding casing at the drug groove of outward expansion, makes the drug groove of outward expansion, and the outer diameter of whole tracheal stent expands along with it, and drives drug coating strip synchronous expansion and presses outward and expands the patient place, realizes that the stent can be in the patient's body self -degradation, and the expansion force of stent can be slowly released in the process of degradation, thereby offset the stent wall thinning after degradation or the trachea natural growth leads to the stent expansion force reduction, dynamically maintained the expansion force of stent, increased the stability of stent.

The invention relates to the technical field of tablet preparation, in particular to a drug coating state detection system and method, and the system comprises a surface pretreatment module, a coating execution module, an online monitoring module, a data processing module and a control module. The pretreatment module is used for removing pollutants through plasma treatment, improving activity and enhancing coating adhesive force; the coating execution module takes a fluidized bed as an environment, and realizes uniform coating in combination with a multi-channel spray gun and posture regulation and control; the on-line monitoring module synchronously collects three-dimensional morphology, spectrum and image data, interference is suppressed, and reliability is guaranteed; the data processing module calculates thickness and uniformity indexes, and associates process and quality by machine learning; and the control module dynamically adjusts the parameters by using a PID algorithm based on the quality parameters, and starts emergency processing when the parameters are abnormal. The method corresponds to the steps. According to the invention, the adhesive force and uniformity of the coating are improved, real-time monitoring and accurate regulation are realized, the quality control difficulty and cost are reduced, and the method is suitable for functional coating production of various tablets.

The pleating and folding integrated device comprises a base, a rotating disc and a plurality of pleating heads, and the base is used for clamping and fixing a balloon; the turntable is rotatably connected to the base and is used for realizing rolling, holding and folding of the balloon; the multiple pleating heads are movably installed on the rotary disc so that pleating of the balloon can be achieved. After the balloon is pleated, the balloon is directly folded, the folding effect is better, the step of transferring the balloon in the pleating and folding process is omitted, the situation that the balloon is scratched due to the fact that the balloon is transferred between different working heads can be avoided, the phenomenon that a hydrophilic coating or a medicine coating of the balloon is incomplete or falls off is prevented, and the balloon is more stable in performance. The product pleating and folding qualification rate is improved, and the operation effect is prevented from being affected.

The invention relates to the field of medicines, and provides a crystal form A of a limus medicine, a preparation method of the crystal form A, a medicine composition and a medicine coating balloon. The crystal form A of the limus medicine is radiated by Cu-Kalpha, is diffracted by X-rays expressed by a 2 theta angle, and has characteristic peaks at 10.2 + / -0.2 degrees, 13.3 + / -0.2 degrees, 14.3 + / -0.2 degrees and 21.7 + / -0.2 degrees. The crystal form A is uniform in structure, good in stability and beneficial to long-time storage; the sustained-release tablet has the advantages of good lipophilicity, low dissolution rate, long residence time in target blood vessels, and realization of continuous sustained release.

The invention belongs to the technical field of medical instruments, and particularly relates to an intracranial drug balloon catheter and a preparation method thereof. A two-time spraying method is adopted, the humidity of carrier gas during two-time spraying is controlled, an amorphous-state drug coating and a crystalline-state combined drug coating are formed on the surface of the balloon catheter, and the drug can be released, permeated and stored within 90 s after the balloon catheter adheres to the wall; further, the technical effects of effectively and lastingly inhibiting the intimal hyperplasia and reducing the restenosis rate are achieved, and the method has excellent trafficability and traceability and can adapt to the complex environment condition of intracranial tortuous blood vessels; meanwhile, the drug coating firmness and release performance can be achieved at the same time, and neurotoxic complications caused by drug falling during in vitro, delivery and expansion are avoided.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

This invention provides a drug-coated balloon catheter, its preparation method, and its application, relating to the field of medical device technology. The drug-coated balloon catheter includes a balloon catheter and a drug coating disposed on the surface of the balloon catheter; the drug coating includes an active drug and an excipient; the active drug is a flavonoid. The drug-coated balloon catheter utilizes flavonoids, which combine the advantages of low toxicity and high water solubility. While reducing the toxic side effects of the drug coating, it achieves rapid release and efficient absorption of the drug. Furthermore, through a dual mechanism of anti-proliferation and anti-inflammation, it effectively solves the problems of potential toxic side effects, limited transport efficiency, and limited functionality that may exist in existing products at high dose densities.

The present invention is related to a drug-coated covered stent the drug coated covered stent is a novel medical device designed to address Type III coronary artery perforations during percutaneous coronary intervention (PCI). This system combines a balloon-expandable stent covered with a biocompatible graft material and coated with cytotoxic drugs at its ends to prevent excess tissue growth and promote endothelialization. through a rapid exchange delivery system, the DCCS can be precisely positioned and expanded within the artery, sealing tears and promoting healing. The device's ultrathin profile and high flexibility enable navigation through tortuous vessels. Key components are a blocking balloon (201), second guidewire (203), covered stent (205), proximal and distal shafts of the delivery system (1, 2, 3, 15 4), stent (5), graft material (6), cytotoxic drug coatings (8, 9), and endothelialization (11). This innovative solution offers a promising approach to managing coronary artery perforations, potentially reducing the need for surgical interventions.

The utility model discloses a driven end holder for medicine coating balloon catheter spraying equipment, which comprises a support, a driven turntable is rotatably connected to the support, and a driving motor for driving the driven turntable to rotate is fixedly connected to one side of the outer side wall of the support. A loading plate is fixedly connected to the side, away from the driving motor, of the outer side wall of the driven rotating disc, a mounting plate is fixedly mounted on the upper surface of the loading plate, a wire winding ring is fixedly connected to the outer side wall of the mounting plate, and U-shaped wire winding storage columns which are annularly and uniformly distributed are rotationally connected to the upper surface of the wire winding ring. Through cooperation of the support, the driven rotating disc, the driving motor, the loading plate, the mounting plate, the wire coiling ring, the U-shaped wire coiling containing column, the clamping assembly and the wire lapping adjusting column, the application range of the device is effectively widened, balloon catheters of different specifications can be rapidly replaced and sprayed, and the overall spraying efficiency of the device is effectively guaranteed.

The invention discloses an intervention device for releasing medicine, which is characterized in that a stent is of a hollow cylindrical structure capable of shrinking along the radial direction of the stent, and the stent is made of a medical material with a shape memory characteristic; the drug coating is coated on the outer side of the stent; the number of the annular air bags is two, the two ends of the support are each provided with one annular air bag along the edge of the end face, the inner diameter of each annular air bag in the initial state is matched with the outer diameter of the unfolded support, a plurality of hoses are arranged between the two annular air bags in the axial direction of the support, the hoses are arranged in the support, and the two ends of each hose are communicated with the corresponding annular air bags. The inflation inlet is formed in the side wall of one annular air bag, and a check valve assembly is arranged at the inflation inlet. The outer ring of the filled and expanded annular air bag can be tightly attached to the inner wall of the blood vessel, blood is prevented from entering the attached area of the medicine coating and the inner wall of the blood vessel, the amount of medicine washed away by the blood flow is reduced, and the release period of the medicine is prolonged.

The present invention relates to a coating material for drug-coated balloons, drug-coated balloons, and a coating solution for drug-coated balloons, as well as their preparation and application. The coating solution comprises an aqueous solvent and a plurality of core-shell structures dispersed in the aqueous solvent, each of which comprises a lipid bilayer coated with a drug. The core of the core-shell structure contains a plurality of drug-loaded particles, and the shell of the core-shell structure is a lipid bilayer with an outer hydrophilic group and an inner hydrophobic group. The drug-loaded particles comprise a plurality of drug-loaded nanocrystalline particles. The combination of nanocrystals and liposomes combines the advantages of these two types of drug carriers. The resulting lipid bilayer improves the solubility of poorly soluble drugs in drug-coated balloons, resulting in a high drug loading capacity, high drug carrier stability, and stable drug crystal form, allowing for controllable drug release rates.

The invention relates to the technical field of drug balloons, in particular to a drug balloon, a drug coating and a preparation method thereof, the drug coating comprises a nano-drug, the nano-drug sequentially comprises drug-loaded nanoparticles, an elastin layer and an adhesion layer from inside to outside, and the adhesion layer comprises a polydopamine coating and a cationic polymer coating. The invention provides the drug particle with excellent adhesion to the target blood vessel, the polydopamine and cationic polymer coating is prepared on the surface of the drug particle, the adhesion can be maintained in a dynamic washing environment, and meanwhile, the elastin with excellent elastic buffering performance is adopted as the middle layer of the drug particle, so that the adhesion of the drug particle can be maintained in a dynamic washing environment. The drug can adapt to periodic expansion, contraction and shear force change of blood vessels, close contact between the drug and blood vessel walls can be kept under blood vessel pulsation and blood flow impact, the adhesion stability of the drug is further enhanced, and the retention rate of the drug in target blood vessels is greatly increased.

The utility model belongs to the field of drug delivery, and particularly relates to a drug balloon catheter. The utility model provides a medicine balloon catheter. The medicine balloon catheter comprises a balloon catheter body, a medicine storage layer and a medicine coating, wherein the outer surface of the balloon catheter body is sequentially coated with the medicine storage layer and the medicine coating. The medicine storage layer comprises one or more layers; when the drug balloon catheter is used for delivery, drugs on the outermost layer enter blood vessels preferentially and are continuously absorbed and metabolized and eliminated along with the half-life period and elimination kinetics of the drugs, and the anti-proliferation effect of the drugs is achieved. The first layer of the microspheres in the storage layer preferentially enters tissues and reaches saturation concentration, so that most of the microspheres are attached to the blood vessel wall, the modification of chitosan increases the contact between the PLGA microspheres and the blood vessel wall, a large amount of medicine is released after the structure of the storage layer collapses, and the released large amount of medicine enters the blood vessel to play a role.

A cobalt-chromium alloy stent comprising several main body units, wherein each main body unit is composed of several supporting rings connected by flexible ribs and the adjacent main body units are connected by several connecting ribs. A drug eluting stent comprising the cobalt-chromium alloy stent and a drug coating containing arsenic trioxide and tacrolimus. The drug release curves of the two composite drugs of arsenic trioxide and tacrolimus used in the present invention are adjusted, so that the inflammatory response of vascular endothelial cells and the proliferation behavior of vascular smooth muscle cells are effectively inhibited, and the vascular restenosis rate is reduced.