53 results about "Butyl methacrylate" patented technology

The present invention relates to the technical field of tackified adhesive films and specifically to a tackified adhesive film. The tackified adhesive film comprises a substrate layer and a UV-tackified adhesive layer applied onto the substrate layer. The UV-tackified adhesive layer is prepared by using a modified polyester resin, which is obtained by the graft polymerization of a hydroxyl-terminated polyester resin, butyl methacrylate, and isocyanatoethyl methacrylate, as a main resin and mixing the main resin with a tackifying resin, a photo-curing agent and the like. The UV-tackified adhesive layer has relatively high cohesive strength and relatively good adhesion to a PET substrate. Before a UV-induced tackification reaction, an initial peel force is not significantly increased with the extension of standing time, so that an adhesive tape can be easily removed without causing damage and contamination such as residual adhesive to an adherend . After the UV-induced tackification reaction, the modified polyester resin can improve the bonding strength between the adhesive tape and the adherend.

The application belongs to the technical field of medical biomaterials, and particularly relates to an interpenetrating network polymer based on phosphorylcholine polymer and a preparation method and application thereof. The application provides a sequential interpenetrating network method, which comprises the following steps: preparing a monomer infiltration solution containing phosphorylcholine monomer, polyethylene glycol methacrylate, dimethylaminoethyl methacrylate, butyl methacrylate, hydroxyethyl methacrylate, ethylene glycol methacrylate, a crosslinking agent and an initiator; dipping a high-molecular polymer matrix into the monomer infiltration solution, and performing ultrasonic oscillation treatment to promote the infiltration of monomers into the interior of the matrix; and performing a polymerization reaction to obtain a final product after washing; the material prepared by the application has excellent thermal stability, excellent swelling performance, intelligent pH response drug release capacity and biocompatibility, and is suitable for the fields of biological medicine and cosmetics.

Disclosed is an LED UV curable coating composition comprising one or more multifunctional aliphatic acrylate oligomers having an acrylate functionality of 2 or more, one or more monofunctional acrylate monomers, one or more difunctional acrylate monomers, methyl and / or butyl methacrylate, an aliphatic acrylate with primary hydroxyl groups, one or more multi-functional amino acrylates, one or more pigments, one or more photoinitiators, a methacrylate modified acidic adhesion agent, one or more UV absorbers, one or more flatteners, and one or more defoamers, and methods thereof.

This invention relates to the field of medical device technology and provides a method for preparing a drug sustained-release coating and a medical device containing the same. The method includes forming a drug sustained-release coating on the surface of the medical device using a drug sustained-release polymer and a drug. The drug sustained-release polymer is a multi-component polymer containing functional groups for anti-protein adsorption, drug sustained-release, and chemical cross-linking. While ensuring the anticoagulant properties and adhesion to the surface of the medical device, the drug sustained-release coating, through the synergistic effect of butyl methacrylate and trimethoxysilyl propyl methacrylate, achieves an initial burst release of less than 20% of the total drug amount and slows down drug release to ensure a drug release cycle in vivo of no less than 21 days. This drug sustained-release coating can release a stable amount of drug to the tissue wall it contacts over a long period, aiming to achieve a long-term therapeutic or preventative effect on diseases such as luminal stenosis.

This application relates to the field of pharmaceutical formulation technology, and particularly to a cefcarditol hydrochloride pulse formulation and its preparation method. The cefcarditol hydrochloride pulse formulation of this application comprises a first particle, a second particle, and a third particle. Each particle, from the inside out, has a particle layer, an isolation layer, and a pulse layer. The pulse layer comprises a film-forming agent and an anti-adhesion agent. The film-forming agent in the first, second, and third particles sequentially comprises one or more of the following: butyl methacrylate-(2-dimethylaminoethyl) methacrylate-methyl methacrylate copolymer, methacrylate-ethyl acrylate copolymer, methacrylate-methyl acrylate copolymer, methyl acrylate-methyl methacrylate-methacrylate copolymer, and shellac. The cefcarditol hydrochloride pulse formulation of this application allows for once-daily dosing, effectively alleviating the problems of difficulty in taking cefcarditol hydrochloride tablets and poor patient compliance.

This invention relates to a class of methacrylate photoresists, their preparation method, and their photolithographic patterning applications, belonging to the fields of chemical synthesis and photolithography materials. The invention utilizes a one-step free radical copolymerization process to prepare photoresist resins from a specific molar ratio of ethyl adamantyl methacrylate, tert-butyl methacrylate, and a hexafluorovinylphenyl monomer. This method not only achieves high yield and high product purity but is also environmentally friendly, providing high-quality raw materials for subsequent processes and suitable for industrial-scale production. The photoresist resin prepared by this invention features controllable molecular weight and a narrow molecular weight distribution. Photoresists containing this polymer resin can significantly improve problems such as unclear etching boundaries and large linewidth roughness, meeting higher photolithographic requirements. The one-step reaction synthesis method and convenient post-processing of the product after the reaction are advantageous. The low cost allows for large-scale production.

The application discloses a plastic embedding agent BMA / IBOMA resin, monomers of the resin are composed of butyl methacrylate (BMA) and isobornyl methacrylate (IBOMA) in a mass ratio of 6:1 to 7:2. The application further discloses a preparation method of the plastic embedding agent, which comprises the steps of mixing the two resins according to the mass percentage, and then adding a crosslinking agent and an initiator. The application further discloses a plastic embedding method compatible with multi-color fluorescence and immunofluorescence labeling, which adopts the BMA / IBOMA resin to embed a biological tissue sample. The embedding method has low cost, and the BMA and IBOMA are used as hydrophobic resin monomers to effectively maintain the fluorescence signal of the sample. In addition, the IBOMA can improve the cutting performance of the sample after embedding, and meet the 1-micron precision cutting requirement of the fMOST system.

The invention provides a cement joint sealing material for repairing high-speed rail roadbed slab cracks and a preparation method of the cement joint sealing material, and relates to the technical field of building materials. 300 parts of a modified acrylate emulsion; 0.6 to 1.2 parts of a defoaming agent; 4.5 to 5.4 parts of a water reducing agent; 0.8 to 1.2 parts of amino modified liquefied lignin; the modified acrylate emulsion is prepared from the following raw materials: a combined monomer, a functional monomer and amino modified liquefied lignin, the combined monomer is prepared from the following components in parts by mass: 3.8 to 4.2 parts of n-butyl acrylate, 3.8 to 4.2 parts of n-butyl methacrylate, 1.4 to 1.6 parts of isobutyl acrylate and 0.4 to 0.6 part of styrene; the functional monomer comprises acrylic acid. The invention provides a synthesis method of a modified acrylate emulsion copolymerized by multiple monomers, and a material meeting the requirement of repairing performance of high-speed rail roadbed slab cracks is prepared based on the emulsion and cement.

The invention discloses a preparation method of poly (p-hydroxystyrene), poly (p-hydroxystyrene) and application, and relates to the technical field of organic synthesis. According to the preparation method, 4-acetoxystyrene, 4-hydroxyphenyl methacrylate, tert-butyl acrylate, tert-butyl methacrylate and 1-ethyl cyclopentyl methacrylate are taken as monomers, and the P (HSt-co-HADMA) copolymers with different HADMA proportions are obtained through RAFT (reversible addition-fragmentation chain transfer) polymerization. According to the copolymer, large-volume side groups are introduced, so that the glass-transition temperature of PHSt is effectively increased, the processing window of subsequent acid diffusion is improved, and the film-forming property of the copolymer is also effectively improved. Along with the increase of the HADMA content, the cracking condition of the film is improved, and the surface roughness is reduced.

The present invention provides electrolyte coatings, solid-state batteries, and power consumption devices. [Solution] The electrolyte coating is applied to the surface of a solid electrolyte, which comprises one or both of a sulfide electrolyte and a halide electrolyte. The electrolyte coating is a copolymer of perfluorohexylethyl methacrylate and butyl methacrylate. The present invention significantly improves the stability in air (even at high humidity) without significantly affecting conductivity by applying the electrolyte coating to the surface of sulfide electrolytes and halide electrolytes.

The application belongs to the field of ophthalmic nano-preparations, and particularly relates to an ophthalmic poly-nitrogen-oxygen amphoteric nano-drug carrier, an ophthalmic nano-preparation and a use. The nano-drug carrier is prepared by using a random copolymer of 2-(N-oxide-N,N-diethylamino)ethyl methacrylate and butyl methacrylate, has an average particle size of 7-12 nm, and can be used for loading ophthalmic drugs such as cyclosporine A. Research shows that the nano-drug carrier has good corneal retention characteristics and corneal permeability, and after loading cyclosporine A, has a good relieving effect on corneal damage and local inflammation of dry eye model animals, and the safety of the nano-drug carrier is good, and the nano-drug carrier has a good application prospect.

The application belongs to the technical field of pharmaceutical excipients, and particularly relates to a methyl methacrylate-butyl methacrylate copolymer and a preparation method thereof; the monomer molar ratio of methyl methacrylate to butyl methacrylate in the copolymer is about 1:2.5-1:3.4, and the butyl methacrylate-methyl methacrylate copolymer has the following structure. The butyl methacrylate-methyl methacrylate copolymer with better adhesion and higher stability is prepared by limiting the monomer ratio, molecular weight and viscosity of the copolymer; and the preparation method of the butyl methacrylate-methyl methacrylate copolymer has the comprehensive advantages of high heat dissipation efficiency, excellent product form and simple post-treatment.

The invention discloses a synchronous belt carbon fiber rope with high wear resistance and a preparation method thereof. The synchronous belt carbon fiber rope comprises a carbon fiber rope and a wear-resistant coating sprayed on the carbon fiber rope, the carbon fiber rope comprises the following raw materials in parts by weight: 30-60 parts of carbon fibers, 40-55 parts of epoxy resin, 20-30 parts of butyl methacrylate and 2-3 parts of a curing agent. The wear-resistant coating comprises the following raw materials in parts by weight: 30-40 parts of polyethylene, 15-20 parts of natural rubber, 3-5 parts of molybdenum disulfide, 1-2 parts of antimony trioxide, 1-2 parts of a coupling agent and 1-2 parts of a vulcanizing agent. The synchronous belt carbon fiber rope is high in strength, good in wear resistance and excellent in heat aging resistance and cold resistance.

The invention discloses a solid adsorbent for selective adsorption of condensate oil chlorinated hydrocarbon. Raw materials of the solid adsorbent comprise an oil phase and a water phase, wherein the oil phase is prepared from the following components in parts by weight: 8 to 10 parts of octadecyl methacrylate, 1 to 3 parts of butyl methacrylate, 1 to 3 parts of diallyl phthalate and 0.5 to 1.0 part of cross-linking agent; the water phase is prepared from the following components in parts by weight: 0.5 to 1.0 part of an initiator, 0.1 to 1.0 part of a dispersing agent and 30 to 80 parts of water. According to the invention, rigid monomer divinyl phthalate is introduced into an acrylate polymerization system, so that a solid adsorbent with a stable three-dimensional porous structure is successfully constructed, and specific adsorption is enhanced through a polar effect while physical adsorption sites are increased; therefore, the solid adsorbent can efficiently adsorb chlorinated hydrocarbon pollutants in condensate oil in a high-capacity mode, and rapid separation and selective removal of the chlorinated hydrocarbon pollutants in an oil phase are achieved.

The application discloses a kind of high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, belong to medical porous hydrogel technical field, specifically related to monomer, crosslinking agent and initiator are added to water and mixed to obtain the reaction solution of temperature-sensitive hydrogel, freeze polymerization obtains ice gel;Ice gel is placed in salt solution and is handled to obtain porous hydrogel;Monomer includes at least one of N-isopropyl acrylamide, N-vinyl caprolactam, N,N-diethyl acrylamide, N-vinyl carbazole, acrylic acid, methyl methacrylate, ethylene glycol methyl ether acrylate, butyl methacrylate, maleic anhydride and styrene.The application provides a kind of temperature-sensitive effect, can be dynamically controlled by electric heating, good mechanical property, good drainage effect high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage.

The invention discloses a high-strength tungsten-copper alloy and a preparation method thereof, and relates to the field of alloys. When the high-strength tungsten-copper alloy is prepared, tungsten, copper and cerium are subjected to mixing, ball milling, pressing and compression molding, and a tungsten-copper alloy matrix is prepared; the preparation method comprises the following steps: reacting vinyl (chloromethyl) dimethylsilane with 4-methylaminopyridine to obtain a pyridine monomer; the preparation method comprises the following steps: reacting N, N-diethylallylamine with 2, 6-di-tert-butyl-4-bromomethylphenol to prepare an anti-aging monomer; mixing an anti-aging monomer, a pyridine monomer, butyl methacrylate, N, N-dimethylformamide, the initiator solution and the emulsifier solution to prepare a surface treatment solution; the preparation method comprises the following steps: treating a tungsten-copper alloy matrix with nitric acid, smearing a surface treatment solution on the surface, curing, and carrying out surface treatment with dimethyldimethoxysilane to obtain the high-strength tungsten-copper alloy. The high-strength tungsten-copper alloy prepared by the invention has waterproof and anti-aging capabilities.

The invention discloses a medical mask with low resistance and high air permeability. The invention provides a medical mask with low resistance and high air permeability, a main body of the medical mask is composed of an air-permeable non-woven fabric, an air-permeable melt-blown fabric and a waterproof non-woven fabric from inside to outside, the air-permeable melt-blown fabric is made of air-permeable melt-blown master batch, and the air-permeable melt-blown master batch comprises the following raw material components in parts by mass: 100 parts of melt-blown polypropylene, 1 part of a flame retardant, 1 part of a lubricant, 1 part of a lubricant and 1 part of a lubricant. 20 to 30 parts of butyl methacrylate grafted polypropylene and 10 to 16 parts of antibacterial modified polypropylene wax. The medical mask is low in air permeation resistance, excellent in air permeability, high in harmful substance blocking rate and good in protection effect.

This invention discloses a waterproof and oil-resistant acrylic emulsion, its preparation method, and its application. The raw materials for the emulsion include monomers, crosslinking agents, initiators, emulsifiers, molecular weight regulators, preservatives, defoamers, neutralizing agents, and pure water. The monomers include methyl methacrylate, polyethylene glycol diacrylate, butyl methacrylate, tert-butyl methacrylate, butyl acrylate, isooctyl acrylate, diacetone acrylamide, and methacrylic acid. This waterproof and oil-resistant acrylic emulsion, as a water-based barrier coating, can be applied to various packaging papers to form a coating similar to a PE film. This coating exhibits outstanding waterproof and oil-resistant barrier properties, excellent anti-tack and folding endurance, and the coated paper can be recycled, replacing PE-coated paper which is difficult to recycle. Furthermore, this waterproof and oil-resistant acrylic emulsion meets food-grade requirements and can be used in food packaging paper.

This invention discloses a high-temperature acid-responsive degradable microencapsulated acid for acid fracturing and its preparation method, belonging to the technical field of chemical materials for acid fracturing in oil and gas fields. The high-temperature acid-responsive degradable microencapsulated acid for acid fracturing includes an acid core and a microcapsule shell encapsulating the acid core. The microcapsule shell is made of a high-temperature acid-responsive degradable polymer material, which is polymerized from five monomers: acrylamide, tert-butyl methacrylate, 2-acrylamide-2-methylpropanesulfonic acid, diallylamine, and allyl polyoxyethylene ether. The microencapsulated acid of this invention can achieve delayed acid release and shell degradation in high-temperature acid solutions, effectively reducing reservoir damage caused by shell residue while ensuring etching capability. It also exhibits strong temperature and shear resistance, making it suitable for acid fracturing operations in high-temperature / ultra-high-temperature carbonate reservoirs.

The application relates to the technical field of organic cotton blended fabric, and discloses a high-hygroscopic organic cotton blended fabric and a preparation process thereof; modified nano silver carbon fibers are prepared by modifying nano silver carbon fibers through graphene aerogels; then a mixed solution is prepared by polyacrylonitrile solution and the modified nano silver carbon fibers, and modified polyacrylonitrile fibers are prepared through spinning; finally, a high-hygroscopic organic cotton blended fabric is prepared by mixing and spinning of organic cotton fibers grafted with butyl methacrylate modified nano titanium dioxide particles and the modified polyacrylonitrile fibers, and the high-hygroscopic organic cotton blended fabric has the advantages of high hygroscopicity, high antibacterial property, high flexibility and high wear resistance.

The invention discloses a modified PVC valve suitable for a strong acid environment and a preparation method of the modified PVC valve. The preparation method comprises the following steps: firstly, carrying out free radical copolymerization on butyl methacrylate, glycidyl methacrylate, 2, 2, 2-trifluoroethyl methacrylate and gamma-methacryloxypropyltrimethoxysilane to synthesize a polymeric auxiliary agent; then melting and mixing the auxiliary agent with chlorinated polyvinyl chloride resin, montmorillonite filler, a stabilizer, a flexibilizer and a processing auxiliary agent to prepare functional master batch; and finally, blending the master batch and resin, and carrying out injection molding. Through the synergistic effect of hydrophobicity of the fluorine-containing monomer and interface bonding of the silane coupling agent, a stable in-situ protection layer is constructed in the material, and the acid permeability resistance, the environmental stress cracking resistance and the long-term dynamic sealing performance of the valve are remarkably improved. The obtained valve has excellent corrosion-resistant durability and structural integrity in a strong acid environment, and is suitable for harsh working conditions such as chemical engineering and electroplating.

The invention relates to an electrostatic spraying process for a flame-retardant electrical cabinet metal plate, and belongs to the technical field of electrical cabinet surface treatment. The electrical cabinet sheet metal part is sequentially subjected to degreasing, acid pickling, phosphating, water washing and drying treatment; the preparation method comprises the following steps: putting epoxy resin, a modified aliphatic amine curing agent, 4-ferrocenyl butyl methacrylate, 4, 4 '-dimercaptodiphenyl sulfide, benzoyl peroxide, a composite flame retardant, a pigment filler, a carboxyl-terminated nitrile rubber flexibilizer, an acrylate leveling agent, an antioxidant and a diluent into a mixing machine, and mixing to obtain plastic spraying powder; the pretreated sheet metal part is placed in a spraying room, electrostatic spraying, curing forming and aftertreatment are conducted on the surface of the sheet metal part, and the flame-retardant electrical cabinet sheet metal part is obtained; the prepared plastic spraying coating is high in oxygen index, the vertical combustion grade reaches the V-0 grade, the flame retardant effect is excellent, and combustion accidents caused by high temperature and electric sparks of an electrical cabinet can be effectively prevented.

The invention relates to the technical field of acrylate adhesives, in particular to medium and low temperature fast curing pure glue and a preparation method thereof.The medium and low temperature fast curing pure glue is prepared from, by weight, 100 parts of acrylic copolymer, 3-20 parts of novolac epoxy resin, 1-15 parts of bisphenol F epoxy resin, 0.01-6 parts of aliphatic amine, 0.1-3 parts of imidazole compound, 0.3-10 parts of aromatic amine and 10-100 parts of solvent; the acrylic copolymer is prepared from the following raw materials: acrylic acid, acrylic acid-2-ethylhexyl ester, ethyl methacrylate, butyl methacrylate, N-hydroxymethyl acrylamide, an initiator and an organic solvent; the weight-average molecular weight of the acrylic copolymer is 100,000-450,000. By optimizing the acrylic acid copolymer to be matched with other raw materials, the peel strength stability of the product under high and low temperature conditions is ensured while the provided product is rapidly cured under medium and low temperature conditions, and the use requirements under severe environments are met.

The application discloses a photoresist and application thereof. The photoresist comprises the following raw materials in parts by mass: 10 parts of resin, 0.1-1 parts of photoacid and 0.1-1 parts of phenyltrimethoxysilane. The resin is an A-B type block copolymer, wherein the A block is a poly-p-hydroxystyrene segment, and the B block is a copolymer segment of tert-butyl methacrylate and methacrylic acid. The photoresist can be used to prepare a photoresist layer which is ultra-thin and has ultra-high uniformity, and meets the requirement of fine pattern processing. The application also provides the application of the photoresist.

The present invention relates to the technical field of pharmaceutical preparations, and in particular to, a cefcapene pivoxil hydrochloride granule and a preparation method therefor. The cefcapene pivoxil hydrochloride granule has a pellet core, an isolation layer, and a taste masking layer from inside to outside; the composition of the pellet core comprises cefcapene pivoxil hydrochloride; and the composition of the taste masking layer comprises a butyl methacrylate-(2-dimethylaminoethyl) methacrylate-methyl methacrylate copolymer. The cefcapene pivoxil hydrochloride granule can ensure complete taste masking in the administration stage, and can be quickly dissolved out after administration, thereby improving the medication experience of a patient and improving compliance, and maintaining the drug efficacy.

To provide an adhesive composition excellent in processability, transparency and reworkability, and to provide an adhesive sheet, an optical member and a display device.SOLUTION: A (meth) acrylic polymer (A) having a reactive functional group and having a weight average molecular weight of 650,000 or more and less than 1.5 million, and a constituent unit derived from t-butyl methacrylate at a ratio of 15% by mass or more and 87% by mass or less with respect to all constituent units, A (meth) acrylic polymer (B) having a glass transition temperature of 105 °C or higher and 150 °C or lower and a weight average molecular weight of 100,000 or more and less than 500,000, and a crosslinking agent, in which a content of the (meth) acrylic polymer (B) is 1 part by mass or more and 40 parts by mass or less with respect to 100 parts by mass of the (meth) acrylic polymer (A), and applications thereof.SELECTED DRAWING: None

An emulsion includes water, an emulsifier, and acrylic polymer particles dispersed in the water. The acrylic polymer particles include monomer units of an alkyl acrylate, alkyl methacrylate, or combination thereof, in which alkyl has at least eight carbon atoms; at least one percent by weight acid-functional monomer units, based on the total weight of the monomer units in the acrylic polymer particles; monomer units of a high Tg monomer comprising at least one of t-octyl acrylamide, t-butyl methacrylate, t-butyl acrylate, isobornyl acrylate, or isobornyl methacrylate; and a chain terminal group having at least four carbon atoms and a thioether group. In some embodiments, the emulsion provides an adhesive able to hold a pinch bond in a foam cube within one minute of spraying the emulsion. A process for making the composition and a process for making a bonded article using the composition are also described.

This invention relates to the field of water-based ink technology, and discloses a stable antibacterial ink and its preparation method. The stable antibacterial ink of this invention comprises the following raw materials in parts by weight: 25-40 parts acrylic acid, 15-25 parts isooctyl acrylate, 10-15 parts butyl methacrylate, 5-8 parts composite antibacterial agent, 1-5 parts modified graphene oxide, 5-8 parts emulsifier, 200-250 parts deionized water, 0.1-0.3 parts initiator, 5-10 parts pigment, and 7-10 parts anhydrous ethanol. The composite antibacterial agent of this invention can effectively inhibit the growth and reproduction of various common pathogenic bacteria, preventing the ink surface from developing odors, mold, or cross-contamination due to microbial contamination. The modified antistatic agent can significantly reduce the surface resistance of the ink coating and dissipate accumulated static charge in a timely manner, thereby further improving the antibacterial and cleaning effect and printing accuracy of the ink.

This invention belongs to the field of catalyst technology, and provides a dedicated catalyst for the synthesis of sec-butyl acetate, its preparation method, and its application. The invention first mixes water and a dispersant to obtain an aqueous phase. A functional monomer, a porogen, and an initiator are then added sequentially to the aqueous phase to carry out a polymerization reaction, yielding a prepolymer. The prepolymer is then mixed with a sulfonating agent and subjected to a sulfonation reaction to obtain a sulfonated resin. Finally, the sulfonated resin is mixed with a solvent and subjected to heat treatment to obtain the catalyst. The functional monomer includes a first monomer, a second monomer, and a crosslinking monomer. The second monomer includes at least one selected from butyl acrylate, butyl methacrylate, ethyl acrylate, and 2-ethylhexyl acrylate. This invention significantly reduces the catalyst's adsorption and reactivity to polycarbonate hydrocarbons, extends the catalyst's lifespan, and improves the selectivity of the catalyst for the synthesis of sec-butyl acetate.

The invention belongs to the field of ophthalmic nano-preparations, and particularly relates to an ophthalmic poly-nitrogen-oxygen zwitterionic nano-drug carrier, a nano-preparation and application. The nano-drug carrier is prepared from a random copolymer of methacrylic acid-2-(N-oxide-N, N-diethylamino) ethyl ester and butyl methacrylate, the average particle size is 7-12 nm, and the nano-drug carrier can be used for loading ophthalmic drugs such as cyclosporine A and the like. Researches show that the nano-drug carrier has good corneal retention characteristics and corneal permeability, has a good relieving effect on corneal injury and local inflammation of xerophthalmia model animals after being loaded with cyclosporin A, and has good safety and good application prospects.