Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

89 results about "Vascular stents" patented technology

A vascular stent is a medical device designed to be inserted into a blood vessel in order to keep it open.

High-performance zinc alloy with gradient structure and preparation method and application thereof

The invention discloses a high-performance zinc alloy with a gradient structure and a preparation method and application thereof, and belongs to the technical field of metal material processing. The high-performance zinc alloy with the gradient structure is characterized in that the grain sizes of upper, middle and lower areas of the alloy are in fine-coarse-fine distribution, the grain sizes of the upper and lower areas are smaller than or equal to 2 microns, the grain size of the central area is 5-20 microns, and the grain size of a transition area between the upper and lower areas and the central area is 2-15 microns; meanwhile, all the areas are accompanied with MnZn13 nano precipitated phases with the size smaller than or equal to 50 nm. The alloy shows excellent deformation resistance and thermal mechanical stability, the elasticity modulus of the alloy can at least reach 125 GPa, meanwhile, the alloy shows excellent corrosion resistance, and the alloy is particularly suitable for biomedical implantation instruments such as intravascular stents and bone nails.
Owner:HOHAI UNIV SUZHOU RES INST

Functional coating, intravascular stent and preparation method and application thereof

The invention discloses a functional coating, an intravascular stent and a preparation method and application of the intravascular stent. The functional coating comprises an endothelialization promoting active substance and an anti-proliferation drug; the endothelialization promoting active substance comprises at least one of polypeptide containing an RGD sequence, polypeptide containing a YIGSR sequence, polypeptide containing an REDV sequence, a beta-polypeptide polymer or a beta-polypeptide-polyester block copolymer. The functional coating disclosed by the invention can be used for surface functional modification of interventional medical devices, can selectively promote adhesion and proliferation of vascular endothelial cells at an implantation part, realizes rapid endothelialization, and can controllably release an anti-proliferation drug to inhibit excessive proliferation of vascular smooth muscle cells, so that the vascular endothelial cells are prevented from being damaged. Therefore, the risks of restenosis and advanced thrombus are effectively reduced.
Owner:BROSMED MEDICAL CO LTD

Corrosion-resistant collagen-functionalized magnesium-based metal coating and preparation method thereof

The invention discloses a corrosion-resistant and collagen-functionalized magnesium-based metal coating and a preparation method of the corrosion-resistant and collagen-functionalized magnesium-based metal coating. Belongs to the technical field of biomedical material preparation. The preparation method comprises the following steps: firstly introducing hydroxyl into the surface of the magnesium alloy through alkali treatment, then sequentially dipping the magnesium alloy into a solution A and a solution B containing specific copolymers, drying to obtain an anti-corrosion coating, and finally coating with a recombinant humanized collagen solution. The copolymer A in the solution A and a magnesium substrate form a firm Si-O-Mg covalent bond through a silane coupling agent, and the fluorine-containing copolymer B in the solution B is tightly combined with a bottom layer through self-assembly, so that a super-hydrophobic anti-corrosion barrier with a stable structure and strong adhesion is constructed. The outermost collagen layer endows the magnesium alloy material with excellent endothelial cell adhesion and proliferation promoting activity. The multi-layer composite coating structure effectively solves the problems that magnesium alloy degradation is too fast, and an existing coating is weak in binding force and lacks biological functions, and has wide application prospects in implantable medical devices such as intravascular stents.
Owner:CHENGDU MINSHAN CHUANGZHI BIOMATERIALS CO LTD

An active exosome scaffold coating, a vascular scaffold and a preparation method and application thereof

ActiveCN121971711BTissue repairBlood vessel
The application provides an active exosome stent coating, a vascular stent and a preparation method and application, and belongs to the technical field of biomedical intervention instruments. The active exosome stent coating of the application adopts stem cell-derived myocardial cell active exosomes which are strengthened by active components of traditional Chinese medicine. Compared with commercial myocardial cells, the stem cell-derived myocardial cells have more significant effects of promoting blood vessels and tissue repair and regeneration, and stronger cytokine secretion capacity. The preparation method of the active exosome stent coating of the application adjusts the introduction sequence and premixing mode of active components such as exosomes and drugs, and enhances the homogeneity and stability. The vascular stent prepared by using the active exosome stent coating of the application has reasonable sequential release kinetics design, can realize precise targeted regulation on human coronary artery smooth muscle cells (HCASMC) in vitro, does not affect the repair potential of endothelial cells, and solves the contradiction between traditional stents in terms of "anti-proliferation and promotion of healing".
Owner:BEIJING UNIV OF CHINESE MEDICINE

Connection structure of vascular stent, vascular stent, and pushing method therefor

PCT designated stageWO2026002083A1StentsIntracranial vascular stentWave shape
The present invention provides a vascular stent and relates to the technical field of medical instruments. The vascular stent comprises a middle portion and an end portion. The end portion is connected to both ends of the middle portion. The middle portion comprises a plurality of wave-shaped support rings arranged in an axial direction. An S-shaped connecting member is arranged between adjacent wave-shaped support rings. Both ends of the S-shaped connecting member are respectively connected to a crest and a trough of the adjacent wave-shaped support rings. A support portion is arranged on the S-shaped connecting member. When the wave-shaped support ring is compressed and a pushing force is applied, the support portion can abut against the crest and / or trough of the wave-shaped support ring. According to the intracranial vascular stent provided by the present invention, two or even more groups of pushing force transmission channels are formed on one S-shaped connecting member, and the pushing force can be more uniformly transmitted to the wave-shaped support rings, thereby reducing the risk of stent deformation caused by excessive local pushing force, significantly improving the pushing performance of the stent in a microcatheter, and solving the problems of existing intracranial vascular stents being difficult to push and prone to folding.
Owner:LELAND BIOTECH (SUZHOU) CO LTD

A covered stent

This invention relates to a covered stent. Capable of radial collapse and expansion, it comprises a first occlusion portion, a stent middle layer, a second occlusion portion, and a support portion connected sequentially from a first end to a second end, and a covering membrane disposed in the first occlusion portion, the stent middle layer, and the second occlusion portion. The covering membrane serves to isolate blood flow. In the radially expanded state, because the outer diameter of the tubular stent middle layer is smaller than the outer diameters of the first and second occlusion portions, the covered stent is fixed to the blood vessel by the occlusion discs at both ends. The stent middle layer does not need to apply radial support force to the inner wall of the blood vessel for enhanced fixation, effectively avoiding tissue pressure. A support portion is provided at the second end of the second occlusion portion, and the outer diameter of the support portion is larger than the outer diameter of the second occlusion portion. The larger diameter effectively prevents the stent from being displaced towards the first end by blood flow, providing double protection for stent fixation.
Owner:LIFETECH SCI (SHENZHEN) CO LTD

Schiff base-sulfonated hyaluronic acid light-cured microsphere, preparation method and application

The invention relates to the technical field of biomedical materials. The invention discloses a Schiff base-sulfonated hyaluronic acid light-cured microsphere as well as a preparation method and application thereof. The microspheres are prepared by condensing DL-lysine and paeonol to generate Schiff base, then conjugating the Schiff base with sulfonated hyaluronic acid through a carbodiimide chemical method, and finally molding by adopting a microfluidic technology and carrying out ultraviolet curing. The metal chelation characteristic of Schiff base is combined with the precise structure regulation advantage of the microspheres, and the prepared microspheres show an excellent synergistic effect when applied to the surfaces of implant materials such as degradable magnesium alloy, iron alloy and zinc alloy: the corrosion resistance of a base material can be remarkably improved, an effective protective layer is formed, and the service life of the microspheres is prolonged. Meanwhile, the compound has multiple biological functions of promoting endothelial cell proliferation, inhibiting excessive proliferation of smooth muscle cells and regulating and controlling macrophages to be polarized to anti-inflammatory phenotypes, and has a wide application prospect in the biomedical fields of intravascular stents, bone fixing instruments and the like.
Owner:ZHENGZHOU UNIV

Porous cell auxetic material, absorbable intravascular stent, preparation device and preparation method

PendingCN121606754AStentsSurgeryAbsorbable polymersAuxetics
The invention provides a porous cell auxetic material, an absorbable intravascular stent, a preparation device and a preparation method, and belongs to the field of medical instruments, holes in porous cells are dumbbell-shaped structural holes, and the dumbbell-shaped structural holes are transversely and vertically alternately formed in the long axis direction and also transversely and vertically alternately formed in the short axis direction; dumbbell-shaped structure holes in a transverse and vertical alternating array are formed, and the short shafts of the dumbbell-shaped structure holes are provided with anti-springback inserting and pulling abutting supporting structures; the shape of the auxetic material during expansion is maintained, shrinkage is prevented when the auxetic material is axially compressed, and lasting supporting force is provided; when the vascular stent is formed by adopting the structure, radial and axial contraction of the vascular stent is prevented, the shape of the vascular stent is maintained, reliable radial supporting force is provided, the smoothness of the blood vessel is ensured, the mechanical performance of the biological absorbable stent is improved, the use amount of the biological absorbable polymer material is reduced, and the wall thickness is reduced.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Internal and external fiber coated intravascular stent as well as preparation method and application thereof

The invention relates to the technical field of medical instruments, in particular to an internal and external fiber coated intravascular stent as well as a preparation method and application thereof. An inner fiber covering film and an outer fiber covering film with certain functions are respectively prepared by utilizing a coaxial electrostatic spinning technology, and the fiber covering film with a core-shell structure is prepared. The inner-layer fiber covering film takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, thrombus and inflammation resistance is realized, and endothelialization is promoted; the anti-thrombus substance loaded on the shell layer is used for resisting acute thrombus, and can be used as a protective layer to ensure the activity of the substance for promoting vascular endothelial growth in the core layer, and the load can realize a slow release function, so that the loss of expected functions due to quick release of the load is avoided. The outer fiber membrane takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, and tissue integration and infection resistance are promoted; antibacterial substances are loaded on the core layer and are slowly released under the wrapping of the shell layer.
Owner:SHANGHAI UNIV +1

Intravascular stent electrode system

The utility model discloses an intravascular stent electrode system which comprises an intravascular stent, an electrode contact, a guide wire, a signal collecting unit and a receiving coil, the intravascular stent can be implanted into a target area of an intracranial vascular system through an operation, and the electrode contact is connected to the intravascular stent and can collect intracranial signals. The guide wire can conduct stimulation current to the electrode contact and transmit signals collected by the electrode contact, the signal collecting unit is connected with the guide wire and can collect the signals transmitted by the guide wire, and the receiving coil is arranged on the signal collecting unit and forms electromotive force through a magnetic field. The electromotive force is converted by the power supply chip and then continuously supplies power to the signal collection unit and the electrode contact, so that the stable work of the signal collection unit can be maintained.
Owner:WUHAN NEURACOM TECH DEV CO LTD

A vascular stent and a method of manufacturing the same

The present application belongs to the technical field of medical devices, and particularly relates to a vascular stent and a preparation method thereof. The preparation method comprises the following steps: firstly, placing a base body of the vascular stent on a rotatable fixing device and immersing an outer surface of the base body into a coating solution; secondly, rotating the base body along with the fixing device around a central axis of the fixing device to perform coating; and thirdly, drying the vascular stent with a coating layer formed on the surface after the base body stops coating. The preparation method of the drug coating of the vascular stent has the advantages of no film formation on the surface of the vascular stent during coating, simple coating operation, easy industrialization and the like. The vascular stent prepared by the method has the advantages of single-side coating and uniform coating of the coating layer.
Owner:FUDAN UNIVERSITY

Tubular fiber-reinforced biological composite artificial blood vessel stent with degradable metamaterial structure

The invention discloses a tubular fiber-reinforced biological composite artificial blood vessel stent with a degradable metamaterial structure. A reinforcing phase of the biological composite material artificial blood vessel stent is a tubular fiber network stent, and a matrix phase is hydrogel; the tube wall of the tubular fiber network stent is of a negative Poisson's ratio structure, and the negative Poisson's ratio structure is constructed by a fiber network formed by mutually crossing fibers; the mechanical property of the biological composite material is changed by regulating and controlling the structural parameters of the tubular fiber network stent, so that the strength of the natural blood vessel is matched with the compliance mechanical property. The problems that in the prior art, the mechanical property of a small-caliber artificial blood vessel is not matched with that of a natural artery, the compliance is insufficient, and precise regulation and control of the mechanical property are difficult to achieve are solved.
Owner:GUIZHOU UNIV

A convenient fixing developing mechanism and a vascular stent thereof

The present application provides a vascular stent, which comprises a supporting framework and a developing mechanism, the supporting framework comprises a plurality of annular wave-shaped supporting rods, and the developing mechanism comprises a developing piece made of developing material, which is stably fixed on any position of the supporting framework. The present application also provides a developing mechanism on a vascular stent.
Owner:HANGZHOU WEIQIANG MEDICAL TECH CO LTD

3D-printed helical biodegradable anti-inflammatory vascular stent and preparation method thereof

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.
Owner:JILIN UNIVERSITY

Medical implant antibacterial cobalt-based alloy

ActiveCN117568692BSurgeryProsthesisCardiovascular stentOrthopedic department
The medical implant antibacterial cobalt-based alloy has the mass percentage composition of Cr: 17-18, Mn: 10.5-11.5, Fe: 22-23.5, W: 4-5, N: 0.1-0.2, Mo: 1.5-1.9, Nb: 0.7-0.85, Zr: 0.05-0.11, Cu: 2.5-3.0, and the balance of Co and inevitable impurities. The alloy has excellent mechanical and processing properties, can be widely applied to the preparation of orthopedic implants, oral implant systems, cardiovascular stents and other medical devices, can effectively reduce the infection risk of implanted devices, and can obviously reduce the corresponding cost of the devices.
Owner:SHANGHAI RUICHANG MEDICAL TECHNOLOGY CO LTD

Drug-loaded intravascular stent and preparation method thereof

The invention provides a drug-loaded intravascular stent and a preparation method thereof.The preparation method of the drug-loaded intravascular stent comprises the steps that drug-loaded microspheres are prepared; wherein the drug-loaded microspheres comprise chitosan nanoparticles loaded with an anti-inflammatory drug, an antibacterial drug layer coating the chitosan nanoparticles, and a PLGA (poly (lactic-co-glycolic acid)) shell layer coating the antibacterial drug layer; mixing the drug-loaded microspheres with PLGA (poly (lactic-co-glycolic acid)) microspheres to prepare a blended wire rod; and according to a digital model, carrying out 3D printing on the blended wire rod to form the drug-loaded intravascular stent.
Owner:XIAN MARK MEDICAL TECH CO LTD

A vascular stent

The utility model discloses a kind of vascular stents, belong to medical instrument field, including multiple intermediate rings, two end rings, first connecting tendon and second connecting tendon, multiple intermediate rings are evenly arranged along the axial direction of vascular stent, intermediate ring includes multiple first wave unit, two end rings are respectively arranged at the both ends of vascular stent, end ring includes multiple second wave unit, the both ends of first connecting tendon are connected with end ring and intermediate ring respectively, one end of first connecting tendon is connected with the end of second wave unit close to first wave unit, the other end of first connecting tendon is connected with the middle position of the crest and trough of first wave unit, the both ends of second connecting tendon are connected with two intermediate rings connected with each other respectively, and the end of second connecting tendon is connected in the middle position of the crest and trough of first wave unit. The embodiment of the application can reduce axial shortening, can optimize the mechanical distribution of end ring in expansion process, reduce the fracture of end ring and optimize stress distribution.
Owner:HUNAN HUAXIANG MEDICAL TECH CO LTD

Vascular stent

The application discloses a vascular stent, which comprises a main stent with a main tube cavity, wherein the main stent comprises a proximal end section, a distal end section and an intermediate section extending axially between the proximal end section and the distal end section; a recess is arranged on the intermediate section; a support structure protruding outward relative to the recess is arranged above the recess; and at least a part of the support structure is degradable. According to the vascular stent, at least a part of the support structure at the top of the vascular stent is made degradable, so that the initial mechanical support function of the recess section is ensured without abandoning the function of the overall structure; in the long term, the part of material can be absorbed automatically under the action of a certain time, thereby reducing the constraint and extrusion on the branch stent, reducing the occupation of the main cavity space and the stimulation influence on the inner wall of the blood vessel.
Owner:FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE +1

A vascular tissue disaggregation device and system

The utility model provides a kind of vascular tissue decomposition circulating device, including reactor bin, and the reactor cover being set to the top of reactor bin;Support mounting device is set in reactor bin, one end of support mounting device is connected to reactor cover, the other end of support mounting device is used to place vascular tissue stent;Reactor bin is opened with water inlet and water outlet, and filter screen is set in water inlet and water outlet, and the water inlet height of water inlet is same with the height that support mounting device places vascular tissue stent, water inlet and water outlet are respectively used to pipeline external connection to the water outlet and water inlet of peristaltic pump circulating device;The side of reactor bin is provided with temperature control device.The utility model is through the structural design of decomposition circulating device, using matching enzyme decomposition liquid, carries out circulating cleaning to vascular tissue, realizes the quick decomposition of vascular tissue, and also can avoid influence or destroy the degradable material on vascular stent surface.
Owner:SUZHOU ZENITH VASCULAR SCITECH LTD

Vascular stent for the intra-abdominal visceral region

PendingCN122075182Apromote thrombosisDoes not affect normal blood flowStentsBlood vesselsFalse lumenThrombus
This invention relates to a vascular stent for the visceral region of the abdominal aorta, comprising an interconnected proximal non-degradable segment and a distal degradable segment. The proximal non-degradable segment includes a non-degradable metal skeleton and a covering structure. The distal degradable segment is a degradable bare skeleton. The proximal non-degradable segment corresponds to the location of the primary tear in the visceral region of the abdominal aorta, and the distal degradable segment corresponds to the location of branch vessels in the visceral region of the abdominal aorta. This invention is applicable to abdominal aortic dissection anatomical features, where the proximal stent segment is non-degradable and covered, while the distal visceral segment is degradable but not covered. It promotes false lumen thrombosis by sealing the primary tear through covering, while maintaining patency of branch vessels in the visceral segment by not covering. Simultaneously, a drug layer is attached to the covering of the proximal stent segment to actively promote intimal repair.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Biodegradable zinc-based materials including dispersed nanostructures for biomedical applications

A biomedical device includes a zinc-based material including a matrix including zinc, and nanostructures dispersed in the matrix. Embodiments of this disclosure are directed to zinc (Zn)-based materials including dispersed nanostructures for biomedical applications and devices, such as bioresorbable vascular stents, bioresorbable ureteral stents, endoluminal springs for distraction enterogenesis, biodegradable bone implants with tunable modulus, guided bone generation membranes, bioresorbable dental membranes, and other biomedical implants, as well as other functional applications, such as biodegradable electronics and sensors.
Owner:RGT UNIV OF CALIFORNIA

Left iliac total vein extravascular stent and operation method

The invention discloses a left iliac total vein extravascular stent and an operation method, and belongs to the field of medical instruments. The stent comprises a middle section connecting sleeve frame, an inferior vena cava sleeve frame and a left iliac vein sleeve frame which are integrally formed, the included angle between the three is 135-145 degrees, an elastic silica gel limiting clamping belt is arranged and made of a silicon rubber material, and the crosslinking density and flexibility are regulated and controlled by adjusting the vinyl content. The surgical method comprises the following steps of: minimally invasive laparoscopic approach, implanting a stent after exposing a target blood vessel, and adjusting the position. Direct contact between the built-in stent and the intima is avoided, the intima hyperplasia and thrombus risks are reduced, fatigue resistance and creep resistance are achieved, the stent is attached to the anatomical structure, fixation is stable, minimally invasive recovery is fast, customizable adaptation can be achieved, and the clinical treatment effect and safety are improved.
Owner:KANGPU JISHI (SHAANXI) HEALTH & LIFE TECHNOLOGY CO LTD

Degradable zinc alloy intravascular stent

The invention provides a degradable zinc alloy intravascular stent which is of a tubular net structure and comprises a plurality of supporting rings (3) arranged in the axial direction and connecting rods (1) connected with the adjacent supporting rings (3). The supporting ring (3) is in a wave shape and is composed of a plurality of supporting rod units which are connected in sequence, each supporting rod unit comprises a first supporting rod in the middle and two arc-shaped parts connected to the two ends of the first supporting rod respectively, and wave crests or wave troughs of the supporting ring (3) are formed at the tops of the arc-shaped parts; every two adjacent supporting rod units are connected by sharing one arc-shaped part; the rod diameter (42) of the middle position (2) of the first supporting rod is W1, and the rod diameter of the first supporting rod is gradually increased from the middle position (2) of the first supporting rod to the arc-shaped parts at the two ends of the first supporting rod. The rod diameter (41) of the supporting ring (3) at the wave crest and the wave trough is W2, and W2 is larger than W1. The rod diameter (32) of the connecting rod (1) is W3, and W3 is smaller than W1.
Owner:SHANGHAI JIAOTONG UNIV

In vivo orientation method and system for vascular stents based on the principle of spatial inversion

PendingCN122297203ALeft subclavian arteryInferior phrenic arteries
This application provides a method and system for in vivo stent orientation based on the principle of spatial reversal, relating to the field of vascular interventional technology. The method includes: during the advancement of a main stent delivery system carrying an integrated branch stent along an ultra-rigid guidewire towards the aortic arch, acquiring the orientation information of the delivery system and its contact force information with the vessel wall; then comparing the orientation information with a spatial reference path, and determining the entry point into the curved section of the aortic arch based on the comparison results; generating a reversal speed adjustment amount based on the deviation of the delivery system's orientation from the branch vessel opening direction, the vessel curvature, and the contact force information; finally, controlling the delivery system to rotate synchronously during advancement based on this adjustment amount, gradually adjusting the orientation of the branch stent from a preset position to directly facing the opening of the left subclavian artery, while dynamically adjusting the advancement speed according to the contact force information to maintain the contact force within a preset safe range. This application improves the accuracy and operational safety of in vivo stent orientation.
Owner:AFFILIATED HOSPITAL OF BINZHOU MEDICAL COLLEGE

Method for simulating unfolding of intravascular stent, electronic equipment and computer readable storage medium

The invention discloses a method for simulating unfolding of an intravascular stent, electronic equipment and a computer readable storage medium, and the method comprises the steps: building a simplified compression model of the intravascular stent in a microcatheter based on the size of the microcatheter, the simplified compression model comprises node particles on a simplified spiral line of a weaving wire and ghost particles on a central axis section of the intravascular stent; acquiring a blood vessel model comprising the target blood vessel segment, wherein the blood vessel model comprises a blood vessel center line and a blood vessel wall; the simplified compression model is arranged along the center line of the blood vessel, the ghost particles are located on the center line of the blood vessel, and the node particles surround the center line of the blood vessel to form a spiral structure; and carrying out geometric shape constraint and physical elastic constraint on the intravascular stent, and simulating an expansion process of the intravascular stent in the target vascular section to obtain an expansion model of the intravascular stent. According to the method provided by the embodiment of the invention, a reliable stent unfolding form can be obtained.
Owner:UNION STRONG (BEIJING) TECH CO LTD

Poly-l-lactide-caprolactone composite material, preparation method and application thereof, and vascular stent

The application belongs to the technical field of biomedical materials, and provides a poly-L-lactide-caprolactone composite material, a preparation method and application thereof, and a vascular stent.The composite material is prepared from poly-L-lactide-caprolactone (PLCL) and metal oxides (one or more of ferroferric oxide, magnesium oxide, zinc oxide and titanium dioxide). Compared with PLLA, the composite material has better strength and toughness; the metal oxides can improve the degradation rate of the polymer PLCL. Therefore, the composite material has excellent toughness, strength and degradation rate. Further, especially when the metal oxide is ferroferric oxide, the elongation at break and tensile strength of the obtained composite material are significantly improved; the in-vitro degradation rate is also significantly improved; and the composite material has excellent biocompatibility.
Owner:BEIJING ADVANCED MEDICAL TECH LTD INC

A high-performance zinc alloy with a gradient structure, its preparation method and application

This invention discloses a high-performance zinc alloy with a gradient structure, its preparation method, and its applications, belonging to the field of metal material processing technology. The high-performance zinc alloy with a gradient structure exhibits a fine-coarse-fine grain size distribution from top to bottom. Specifically, the grain size in the top and bottom regions is ≤2 μm, the grain size in the central region is 5–20 μm, and the grain size in the transition region between the top / bottom and central regions is 2–15 μm. Simultaneously, all regions are accompanied by MnZn particles with a size ≤50 nm. 13 Nanoscale precipitates. The alloy of this invention exhibits excellent resistance to deformation and thermomechanical stability, with an elastic modulus of at least 125 GPa. It also demonstrates excellent corrosion resistance, making it particularly suitable for biomedical implantable devices such as vascular stents and bone screws.
Owner:HOHAI UNIV SUZHOU RES INST

Multifunctional intravascular stent for diabetics and preparation method of multifunctional intravascular stent

PendingCN120815228ASurgeryCoatingsIMMUNE SUPPRESSANTSDrug synergism
The invention discloses a multifunctional intravascular stent for diabetics and a preparation method of the multifunctional intravascular stent, and relates to the technical field of cardiovascular interventional therapy instruments. The polycitrate is used as a carrier on the surface of the intravascular stent body to form the drug-loaded slow-release coating, and the drug-loaded slow-release coating has high antioxidant content, can provide oxidative stress attenuation continuously for a long time, provides a good microenvironment for cell tissue recovery, and promotes regeneration and repair of blood vessels. The biological immunosuppressor and the diabetes specific drug are loaded in the drug-loaded slow-release coating, the biological immunosuppressor is a drug having an excellent effect on common patients, the diabetes specific drug is a drug having a specific effect on diabetic patients, and the two drugs have a synergistic effect, so that the effect of treating diabetes is achieved; the coating on the surface of the intravascular stent has the effects of resisting inflammation, improving endothelial dysfunction and inhibiting proliferation and migration of smooth muscle cells aiming at diabetic patients so as to promote regeneration and repair of diseased blood vessels of the diabetic patients.
Owner:DONGGUAN PEOPLES HOSPITAL

A self-expanding return cannula for ECMO

The application discloses a self-expanding reflux cannula for ECMO and relates to the technical field of medical devices.The self-expanding reflux cannula comprises an implantation tube, a sleeve and a connecting pipe.The implantation tube comprises an inner covering film, an outer covering film and a self-expanding vascular stent.The inner covering film is arranged on the inner wall of the self-expanding vascular stent, and the outer covering film is arranged on the outer wall of the self-expanding vascular stent.The self-expanding vascular stent is in a mesh tube structure and can be radially expanded and contracted.The inner covering film and the outer covering film are both in a tubular shape and can be radially expanded and contracted with the self-expanding vascular stent.The sleeve is arranged on the implantation tube and can be separated from the implantation tube.The sleeve is used for maintaining the implantation tube in a radially contracted state.The one end of the connecting pipe is in communication with one end of the implantation tube, and the other end of the connecting pipe is used for being in communication with an arterial blood outlet of an ECMO system.The implantation tube, the sleeve and the connecting pipe are all flexible tubes.The cannula can be adapted to various blood vessels of different sizes, can avoid causing arterial blood vessel injury due to expansion of the blood vessel and can also supply blood to a distal limb end.
Owner:BEIHANG UNIV

Pressing and holding device and pressing and holding method for intravascular stent

The invention discloses a pressing and holding device and method for an intravascular stent, and mainly relates to the technical field of medical instruments. Comprising a plurality of sets of pressing and holding mechanisms which are arranged in parallel, first columnar protrusions are arranged on the two sides of a pressing and holding petal on one pressing and holding mechanism, second columnar protrusions are arranged on one sides of pressing and holding petals on the other pressing and holding mechanisms, and round grooves matched with the adjacent first columnar protrusions or the second columnar protrusions in an inserted mode are formed in the other sides of the pressing and holding petals. Sliding grooves parallel to the radial grooves are formed in the two sides of the pressing and holding petals, a pressing and holding handle and a plurality of telescopic rods arranged between the two fixing frames are further included, and after the two ends of each telescopic rod penetrate through the fixing frames, fixing nuts and sliding sleeves which make contact with the fixing frames are arranged at the two ends of each telescopic rod respectively. The device has the advantages that the problem that the device cannot adapt to intravascular stents of different specifications and lengths is solved, the operation step of pressing and holding the intravascular stent is simplified, the efficiency of pressing and holding the intravascular stent is improved, the cost of medical equipment is reduced, and the clinical diversified pressing and holding requirements are met.
Owner:SHANDONG HUAAN BIOTECH CO LTD