194 results about "Vascular stents" patented technology

The invention discloses a high-performance zinc alloy with a gradient structure and a preparation method and application thereof, and belongs to the technical field of metal material processing. The high-performance zinc alloy with the gradient structure is characterized in that the grain sizes of upper, middle and lower areas of the alloy are in fine-coarse-fine distribution, the grain sizes of the upper and lower areas are smaller than or equal to 2 microns, the grain size of the central area is 5-20 microns, and the grain size of a transition area between the upper and lower areas and the central area is 2-15 microns; meanwhile, all the areas are accompanied with MnZn13 nano precipitated phases with the size smaller than or equal to 50 nm. The alloy shows excellent deformation resistance and thermal mechanical stability, the elasticity modulus of the alloy can at least reach 125 GPa, meanwhile, the alloy shows excellent corrosion resistance, and the alloy is particularly suitable for biomedical implantation instruments such as intravascular stents and bone nails.

The invention relates to the technical field of medical instruments, in particular to a balloon delivery microcatheter and a using method thereof.The microcatheter comprises a handle, a balloon delivery pipe, a balloon delivery pipe and a balloon delivery pipe, the catheter body is connected with the handle, and the catheter body sequentially comprises a near-end tube, a balloon tube and a far-end tube from near to far; wherein the catheter body is of a double-cavity structure and comprises an inner cavity and an outer cavity, the inner cavity is a channel, one end of the inner cavity is communicated with the first connector, and the other end of the inner cavity penetrates to the end of the far-end tube and is used for conveying instruments, therapeutic drugs or diagnostic radiography liquid; one end of the outer cavity is communicated with the second connector, the other end of the outer cavity is communicated with the balloon tube, and the outer cavity is used for filling and pressure relief of the balloon tube. The balloon catheter has the functions of a micro catheter and a balloon catheter, a near-end blood vessel can be blocked, temporary blocking of local blood flow is achieved, the balloon catheter is further used for expanding the position, not attached to the wall, of an intravascular stent, the stent can be better attached to the blood vessel wall, and therefore pain and risks of a patient are reduced.

The invention discloses a shape memory intravascular stent capable of body temperature recovery and a preparation method thereof, and the preparation method comprises the following steps: drying polylactic acid granules, adding PEG for toughening, carrying out melt blending, adding polylactic acid fibers as a reinforcing phase, and carrying out screw extrusion to obtain a composite material. The toughness of the shape memory material is improved, the shape recovery temperature of the shape memory material is reduced, and shape recovery under the human body temperature is achieved. The intravascular stent is prepared through 3D printing, and the prepared shape memory intravascular stent has good recovery rate and fixation rate, lower recovery temperature and good biocompatibility.

The utility model relates to an intravascular stent, a stent system and a windowing area adjusting method, a stent body section is provided with a stent body inner cavity with two through ends, a branch window penetrating through the stent body inner cavity is formed in the side wall of the stent body section, and the branch window is located on the side wall of the first end of the stent body section and formed to the end side of the first end of the stent body section; the pipe body section is provided with a pipe body inner cavity with two through ends, and one end part of the pipe body section is connected with the second end part of the frame body section, so that the pipe body inner cavity is communicated with the frame body inner cavity. The branch windows of the two intravascular stents can be spliced into a complete closed window, and the overlapped length of the two intravascular stents can be adjusted to adapt to the actual sizes of the three branches on the arch to construct a windowing area with a proper size, so that the blood supply of the three branches on the arch is ensured. When the stent is used for interventional operation, in-vitro windowing or in-situ windowing is not needed, and when the stent is used for open operation, the number of anastomotic stomas can be reduced, the circulation stopping time can be shortened, and meanwhile the three-branch anatomical structure on the arch can be reserved. Therefore, the existing operation requirements are met.

The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and belongs to the technical field of medical treatment. The surface of the fucoidin-bioactive peptide coating intravascular stent is coated with a composite coating, and the composite coating is composed of fucoidin and bioactive peptide. The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and the fucoidin-bioactive peptide coated intravascular stent not only solves the problems of poor blood compatibility and slow endothelialization, but also has multiple functions of anticoagulation, anti-proliferation and repair promotion. The intravascular stent coating technology is comprehensively upgraded, and a safer, more effective and more lasting solution is provided for treatment of cardiovascular diseases.

The invention relates to an intelligent cerebrovascular stent based on polymer short fibers and a preparation method thereof. The method comprises the following steps: carrying out electrostatic spinning on a polymer spinning solution to obtain polymer long fibers, freezing the polymer long fibers in liquid nitrogen, and carrying out low-temperature shearing dispersion to obtain polymer short fibers; a polymer in the polymer spinning solution is at least one of polycaprolactone, polylactic acid, gelatin, cellulose, fibroin, collagen and chitosan; uniformly mixing the temperature response high-molecular polymer and the polymer short fiber to obtain a 4D printing raw material; and designing a 4D printing model of a spider-leg-imitating structure, and performing 4D printing on a 4D printing raw material to obtain the intelligent cerebrovascular stent. According to the preparation method, the intelligent cerebrovascular stent with the spider-leg-imitating structure is prepared, the spider-leg-imitating structure design and the introduction of the polymer short fibers can endow the cerebrovascular stent with better shape adaptability and intelligent responsiveness, and the mechanical property and the anti-skid property of the cerebrovascular stent are effectively improved.

The invention discloses an intravascular stent anchoring degree evaluation method, device and equipment and a storage medium, and the method comprises the steps: building a mapping relation between the radial supporting force of an intravascular stent and the radius of the intravascular stent, defining an anchoring force index used for evaluating the anchoring degree of the intravascular stent, processing the blood vessel image data, generating a three-dimensional blood vessel model, and obtaining the anchoring degree of the intravascular stent. The method comprises the following steps: establishing an anchoring force index, combining the anchoring force index, implementing an intravascular stent virtual implantation process on a computer, calculating and updating the anchoring force indexes of the intravascular stent at different positions in a blood vessel in real time according to the actual expansion degree of the intravascular stent, finally collecting clinical follow-up data after the intravascular stent is implanted, and combining the anchoring force index to extract key feature parameters. And training by using a machine learning model to obtain a trained intravascular stent anchoring degree evaluation model so as to evaluate the anchoring degree of the intravascular stent. According to the method, the anchoring force index is provided from the mechanical angle, and the anchoring degree of the intravascular stent can be evaluated more accurately.

The invention provides a self-expanding hydrogel intravascular stent and a preparation method thereof, and belongs to the technical field of medical instruments, the intravascular stent is of a hollow tubular structure, and the tube wall is of a sealed type; the intravascular stent is made of a hydrogel material. After the hydrogel stent shrinks, the size of the hydrogel stent is obviously reduced, the hydrogel stent can be delivered to a target position in a balloon intervention mode, and the hydrogel stent can stay at the target position and provide a supporting effect on the hydrogel stent due to the fact that the hydrogel stent has a self-expansion effect.

The invention discloses an extravascular stent, which belongs to the technical field of intravascular stents, and comprises: a fixed seat comprising a fixed support and a belt body; the fixing support is suitable for being nested on a first blood vessel adjacent to an anastomotic stoma, a fixing part is arranged at one end of the fixing support, and a through hole is formed in the fixing part; one end of the shoelace body is fixed at the other end of the fixed support, and the other end of the shoelace body can penetrate through the through hole; the fixing piece is provided with a fixing structure capable of fixing the belt body on the through hole; the sleeve is connected to the fixed support, and the sleeve is suitable for being arranged on the periphery of the second blood vessel close to the anastomotic stoma in a sleeving mode. The extravascular stent is simple in structure, the fixing position of the belt body on the fixing piece can be adjusted according to the diameters of different first blood vessels, the fixing support of the extravascular stent can be firmly fixed to the anastomotic stoma position all the time, and applicability is higher.

The invention provides a conveying device. The conveying device comprises a main stent conveying pipe and a multi-cavity pipe. The main stent conveying pipe is used for conveying an intravascular stent, and a branch opening is formed in the intravascular stent; the multi-cavity tube comprises a plurality of cavities, the cavities have different axial lengths, the preset guide wire is preset in at least one branch opening, and the multi-cavity tube can reach the branch opening along the preset guide wire to establish a passage from the branch opening to the branch blood vessel. According to the conveying device, the intravascular stent can be conveyed only through the lower limb admission passage, the intravascular stent does not need to be conveyed from the upper limb admission passage, and damage to healthy blood vessels is reduced.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent. According to the specific technical scheme, the intravascular stent comprises a stent skeleton, after the stent skeleton is subjected to surface treatment, at least one layer of film covering section is arranged outside the stent skeleton, and medicine release sections are arranged at the two ends of the stent skeleton. The problems that in the drug release process of an existing stent, the drug release rate is uneven, biocompatibility is poor, and thrombus and restenosis are caused by a metal stent are solved.

The invention discloses a functional coating, an intravascular stent and a preparation method and application of the intravascular stent. The functional coating comprises an endothelialization promoting active substance and an anti-proliferation drug; the endothelialization promoting active substance comprises at least one of polypeptide containing an RGD sequence, polypeptide containing a YIGSR sequence, polypeptide containing an REDV sequence, a beta-polypeptide polymer or a beta-polypeptide-polyester block copolymer. The functional coating disclosed by the invention can be used for surface functional modification of interventional medical devices, can selectively promote adhesion and proliferation of vascular endothelial cells at an implantation part, realizes rapid endothelialization, and can controllably release an anti-proliferation drug to inhibit excessive proliferation of vascular smooth muscle cells, so that the vascular endothelial cells are prevented from being damaged. Therefore, the risks of restenosis and advanced thrombus are effectively reduced.

The invention discloses a corrosion-resistant and collagen-functionalized magnesium-based metal coating and a preparation method of the corrosion-resistant and collagen-functionalized magnesium-based metal coating. Belongs to the technical field of biomedical material preparation. The preparation method comprises the following steps: firstly introducing hydroxyl into the surface of the magnesium alloy through alkali treatment, then sequentially dipping the magnesium alloy into a solution A and a solution B containing specific copolymers, drying to obtain an anti-corrosion coating, and finally coating with a recombinant humanized collagen solution. The copolymer A in the solution A and a magnesium substrate form a firm Si-O-Mg covalent bond through a silane coupling agent, and the fluorine-containing copolymer B in the solution B is tightly combined with a bottom layer through self-assembly, so that a super-hydrophobic anti-corrosion barrier with a stable structure and strong adhesion is constructed. The outermost collagen layer endows the magnesium alloy material with excellent endothelial cell adhesion and proliferation promoting activity. The multi-layer composite coating structure effectively solves the problems that magnesium alloy degradation is too fast, and an existing coating is weak in binding force and lacks biological functions, and has wide application prospects in implantable medical devices such as intravascular stents.

The application provides an active exosome stent coating, a vascular stent and a preparation method and application, and belongs to the technical field of biomedical intervention instruments. The active exosome stent coating of the application adopts stem cell-derived myocardial cell active exosomes which are strengthened by active components of traditional Chinese medicine. Compared with commercial myocardial cells, the stem cell-derived myocardial cells have more significant effects of promoting blood vessels and tissue repair and regeneration, and stronger cytokine secretion capacity. The preparation method of the active exosome stent coating of the application adjusts the introduction sequence and premixing mode of active components such as exosomes and drugs, and enhances the homogeneity and stability. The vascular stent prepared by using the active exosome stent coating of the application has reasonable sequential release kinetics design, can realize precise targeted regulation on human coronary artery smooth muscle cells (HCASMC) in vitro, does not affect the repair potential of endothelial cells, and solves the contradiction between traditional stents in terms of "anti-proliferation and promotion of healing".

The invention relates to a superfine magnesium alloy wire and a preparation method and application thereof.The preparation method comprises the following steps that S1, smelting is conducted, specifically, magnesium alloy raw materials are mixed and heated, and an alloy ingot is prepared; s2, extrusion is conducted, specifically, the alloy cast ingot is subjected to hot-pressing extrusion, and a wire rod with the diameter being 10-15 mm is obtained; s3, rotary forging is conducted, specifically, rotary forging machining is conducted on the wire rod N times, N is a positive integer larger than or equal to 3, and a thick wire is obtained; and S4, wire drawing is conducted, specifically, the thick wire is subjected to multi-pass continuous reducing drawing, annealing is conducted before each time of drawing, the single-pass reducing rate is controlled to be 10%-20% till the diameter is smaller than or equal to 0.6 mm, fine drawing is conducted, the single-pass reducing rate is controlled to be smaller than or equal to 5% till the diameter is 0.2-0.4 mm, surface polishing is conducted, and the superfine magnesium alloy wire is obtained. According to the method, the tensile strength of the material is improved, the surface smoothness meets the medical-grade requirement, collaborative optimization of the mechanical property and the microstructure of the obtained superfine magnesium alloy wire is achieved, and the superfine magnesium alloy wire is completely matched with use scenes such as anastomosis nails and intravascular stents.

The present invention relates to a peripheral vascular stent, which comprises a plurality of support units arranged at intervals and a membrane. Each support unit is formed by a silk thread and is a closed ring shape. Each support unit comprises a plurality of peaks and valleys that are centered on the axis of the peripheral vascular stent and are arranged periodically in the circumferential direction. Two adjacent peak tops form one cycle. The membrane is covered on the plurality of support units. The flexibility of the membrane is greater than that of the support unit. A plurality of hollowed-out areas are formed on the silk threads of the same support unit and / or on the membrane between two adjacent support units. Two adjacent support units are connected only through the membrane outside the hollowed-out areas. The vascular stent of the present invention can meet the mechanical property requirements under various deformation states of the lower limb artery, has appropriate radial supporting force and good flexibility, can well reduce the chronic outward expansion force in the vascular stent. The vascular stent of the present invention has little influence on blood flow, little damage to the inner wall of the blood vessel, and is not easy to cause secondary thrombosis formation.

The present invention provides a vascular stent and relates to the technical field of medical instruments. The vascular stent comprises a middle portion and an end portion. The end portion is connected to both ends of the middle portion. The middle portion comprises a plurality of wave-shaped support rings arranged in an axial direction. An S-shaped connecting member is arranged between adjacent wave-shaped support rings. Both ends of the S-shaped connecting member are respectively connected to a crest and a trough of the adjacent wave-shaped support rings. A support portion is arranged on the S-shaped connecting member. When the wave-shaped support ring is compressed and a pushing force is applied, the support portion can abut against the crest and / or trough of the wave-shaped support ring. According to the intracranial vascular stent provided by the present invention, two or even more groups of pushing force transmission channels are formed on one S-shaped connecting member, and the pushing force can be more uniformly transmitted to the wave-shaped support rings, thereby reducing the risk of stent deformation caused by excessive local pushing force, significantly improving the pushing performance of the stent in a microcatheter, and solving the problems of existing intracranial vascular stents being difficult to push and prone to folding.

This invention relates to a covered stent. Capable of radial collapse and expansion, it comprises a first occlusion portion, a stent middle layer, a second occlusion portion, and a support portion connected sequentially from a first end to a second end, and a covering membrane disposed in the first occlusion portion, the stent middle layer, and the second occlusion portion. The covering membrane serves to isolate blood flow. In the radially expanded state, because the outer diameter of the tubular stent middle layer is smaller than the outer diameters of the first and second occlusion portions, the covered stent is fixed to the blood vessel by the occlusion discs at both ends. The stent middle layer does not need to apply radial support force to the inner wall of the blood vessel for enhanced fixation, effectively avoiding tissue pressure. A support portion is provided at the second end of the second occlusion portion, and the outer diameter of the support portion is larger than the outer diameter of the second occlusion portion. The larger diameter effectively prevents the stent from being displaced towards the first end by blood flow, providing double protection for stent fixation.

The invention belongs to the technical field of intravascular stents, and discloses a degradable balloon stent and a preparation method thereof.The degradable balloon stent comprises a net-shaped stent body, the stent body is cylindrical, the inner side of the stent body is connected with an inflation balloon in a sleeved mode, and the inflation balloon is used for sending the stent body to an affected part and expanding the stent body; the whole outer cylindrical wall of the stent is wrapped and connected with a drug bearing layer, the drug bearing layer uniformly bears an anti-proliferation drug, and the material of the drug bearing layer is an absorbable material; wherein the medicine bearing layer is arranged to be of an expandable or contractible structure, and when the stent is expanded, the medicine bearing layer is expanded along with the stent; the problem that the occurrence rate of restenosis of positions corresponding to stent meshes is high is solved.

The invention relates to the technical field of biomedical materials. The invention discloses a Schiff base-sulfonated hyaluronic acid light-cured microsphere as well as a preparation method and application thereof. The microspheres are prepared by condensing DL-lysine and paeonol to generate Schiff base, then conjugating the Schiff base with sulfonated hyaluronic acid through a carbodiimide chemical method, and finally molding by adopting a microfluidic technology and carrying out ultraviolet curing. The metal chelation characteristic of Schiff base is combined with the precise structure regulation advantage of the microspheres, and the prepared microspheres show an excellent synergistic effect when applied to the surfaces of implant materials such as degradable magnesium alloy, iron alloy and zinc alloy: the corrosion resistance of a base material can be remarkably improved, an effective protective layer is formed, and the service life of the microspheres is prolonged. Meanwhile, the compound has multiple biological functions of promoting endothelial cell proliferation, inhibiting excessive proliferation of smooth muscle cells and regulating and controlling macrophages to be polarized to anti-inflammatory phenotypes, and has a wide application prospect in the biomedical fields of intravascular stents, bone fixing instruments and the like.

The invention provides an intravascular stent and a manufacturing method thereof. The intravascular stent comprises a stent near end, a stent body and a stent far end which are sequentially arranged in the axial direction of the intravascular stent, and the supporting force of at least one of the stent near end and the stent far end is smaller than that of the stent body. By means of the configuration, the stimulation effect of one end or two ends of the stent on non-lesion blood vessels can be reduced, endothelialization of the non-lesion blood vessels is better facilitated, and the risk of long-term restenosis is reduced.

The present invention relates to the field of medical device technology, and provides a fiber optic balloon catheter comprising at least: a balloon body, the surface of which is coated with a drug that promotes vascular repair; and optical fibers, a plurality of which are evenly spaced on the outer surface of the balloon body along the circumferential direction of the balloon body. Compared to the prior art method of arranging the optical fibers inside the balloon body, the fiber optic balloon catheter provided by the present invention evenly arranges the optical fibers on the outer surface of the balloon body, thereby reducing the impact of the balloon body on the optical fiber light, allowing the light emitted by the optical fiber to evenly illuminate the surface of the balloon body or the blood vessel wall, thereby activating the drug that promotes vascular repair, inducing cross-linking of proteins in the blood vessel wall, forming a natural blood vessel stent, and maintaining the expanded blood vessel.

The invention provides an intracranial vascular stent, and relates to the technical field of medical instruments.The intracranial vascular stent comprises a middle part and end parts, the end parts are connected to the two ends of the middle part, the middle part comprises a plurality of wave-shaped supporting rings arranged in the axial direction, and S-shaped connecting rods are arranged between the adjacent wave-shaped supporting rings; the two ends of the S-shaped connecting rods are connected with the wave crests and the wave troughs of the adjacent wave-shaped supporting rings respectively, supporting parts are arranged on the S-shaped connecting rods, and when the wave-shaped supporting rings are compressed, the supporting parts can abut against the wave crests and / or the wave troughs of the wave-shaped supporting rings. According to the intracranial vascular stent provided by the invention, two or more groups of pushing force transmission channels are formed on one S-shaped connecting rod, so that pushing force can be more uniformly transmitted to the wave-shaped supporting ring, the risk of stent deformation caused by overlarge local pushing force is reduced, the pushing performance of the stent in a micro-catheter is remarkably improved, and the stent can be applied to a micro-catheter. The problems that an existing intracranial vascular stent is difficult to push, prone to being folded and the like are solved.

The invention provides a porous cell auxetic material, an absorbable intravascular stent, a preparation device and a preparation method, and belongs to the field of medical instruments, holes in porous cells are dumbbell-shaped structural holes, and the dumbbell-shaped structural holes are transversely and vertically alternately formed in the long axis direction and also transversely and vertically alternately formed in the short axis direction; dumbbell-shaped structure holes in a transverse and vertical alternating array are formed, and the short shafts of the dumbbell-shaped structure holes are provided with anti-springback inserting and pulling abutting supporting structures; the shape of the auxetic material during expansion is maintained, shrinkage is prevented when the auxetic material is axially compressed, and lasting supporting force is provided; when the vascular stent is formed by adopting the structure, radial and axial contraction of the vascular stent is prevented, the shape of the vascular stent is maintained, reliable radial supporting force is provided, the smoothness of the blood vessel is ensured, the mechanical performance of the biological absorbable stent is improved, the use amount of the biological absorbable polymer material is reduced, and the wall thickness is reduced.

The invention relates to the technical field of medical instruments, in particular to an internal and external fiber coated intravascular stent as well as a preparation method and application thereof. An inner fiber covering film and an outer fiber covering film with certain functions are respectively prepared by utilizing a coaxial electrostatic spinning technology, and the fiber covering film with a core-shell structure is prepared. The inner-layer fiber covering film takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, thrombus and inflammation resistance is realized, and endothelialization is promoted; the anti-thrombus substance loaded on the shell layer is used for resisting acute thrombus, and can be used as a protective layer to ensure the activity of the substance for promoting vascular endothelial growth in the core layer, and the load can realize a slow release function, so that the loss of expected functions due to quick release of the load is avoided. The outer fiber membrane takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, and tissue integration and infection resistance are promoted; antibacterial substances are loaded on the core layer and are slowly released under the wrapping of the shell layer.

The utility model discloses an intravascular stent electrode system which comprises an intravascular stent, an electrode contact, a guide wire, a signal collecting unit and a receiving coil, the intravascular stent can be implanted into a target area of an intracranial vascular system through an operation, and the electrode contact is connected to the intravascular stent and can collect intracranial signals. The guide wire can conduct stimulation current to the electrode contact and transmit signals collected by the electrode contact, the signal collecting unit is connected with the guide wire and can collect the signals transmitted by the guide wire, and the receiving coil is arranged on the signal collecting unit and forms electromotive force through a magnetic field. The electromotive force is converted by the power supply chip and then continuously supplies power to the signal collection unit and the electrode contact, so that the stable work of the signal collection unit can be maintained.

The present invention relates to the field of medical devices, and specifically to a self-expanding vascular stent dedicated to cerebrovascular occlusion lesions, which includes a plurality of self-expanding segments; any one of the self-expanding segments is respectively arranged in a ring shape, and the inner cavities of two adjacent self-expanding segments communicate with each other; the axial two ends of any one of the self-expanding segments are respectively a head end and a tail end, and in two adjacent self-expanding segments, a preset distance is left between the tail end of one of the self-expanding segments and the head end of the other self-expanding segment; a movable and inseparable connection structure is formed between two adjacent self-expanding segments through a connecting component. By setting a preset distance between two adjacent self-expanding segments, the effect of reducing or avoiding mutual extrusion of the two self-expanding segments is produced.

The present application belongs to the technical field of medical devices, and particularly relates to a vascular stent and a preparation method thereof. The preparation method comprises the following steps: firstly, placing a base body of the vascular stent on a rotatable fixing device and immersing an outer surface of the base body into a coating solution; secondly, rotating the base body along with the fixing device around a central axis of the fixing device to perform coating; and thirdly, drying the vascular stent with a coating layer formed on the surface after the base body stops coating. The preparation method of the drug coating of the vascular stent has the advantages of no film formation on the surface of the vascular stent during coating, simple coating operation, easy industrialization and the like. The vascular stent prepared by the method has the advantages of single-side coating and uniform coating of the coating layer.

The invention discloses an antibacterial compound containing shellac nanoparticles and a preparation method of the antibacterial compound, and belongs to the technical field of medical materials. The antibacterial product is a polylactic acid-glycolic acid copolymer (PLGA) loaded shellac nanoparticle antibacterial coating or hyaluronic acid (HA) loaded shellac nanoparticle antibacterial gel. The coating and the gel prepared by the invention have excellent antibacterial performance and good biocompatibility, and the preparation method is relatively simple. The antibacterial coating can be applied to the surfaces of medical instruments such as intravascular stents, artificial heart valves, artificial blood pumps, artificial blood vessels, catheters and vein filters to improve the antibacterial performance of the medical instruments, and can also be applied to the surfaces of skin and mucosa to improve the antibacterial performance.

The invention discloses a preparation method of a ternary developable NiTiTa shape memory alloy, which is characterized in that Ni, Ti and Ta metal particles are adopted as raw materials, and are sequentially subjected to vacuum arc melting, homogenization treatment, hot rolling, solution treatment and annealing treatment to form the shape memory alloy. According to the NiTiTa alloy, the developing property is improved, meanwhile, excellent mechanical property and biocompatibility are kept, and the NiTiTa alloy is suitable for medical instruments such as orthopedic implants and cardiovascular stents and particularly has wide application prospects in scenes (such as postoperative tracking and fault diagnosis) needing precise image guidance. According to the technical scheme, the functionality and applicability of the material are remarkably expanded, and an innovative solution is provided for development of intelligent medical materials.