18 results about "Vascular stents" patented technology

The application provides an active exosome stent coating, a vascular stent and a preparation method and application, and belongs to the technical field of biomedical intervention instruments. The active exosome stent coating of the application adopts stem cell-derived myocardial cell active exosomes which are strengthened by active components of traditional Chinese medicine. Compared with commercial myocardial cells, the stem cell-derived myocardial cells have more significant effects of promoting blood vessels and tissue repair and regeneration, and stronger cytokine secretion capacity. The preparation method of the active exosome stent coating of the application adjusts the introduction sequence and premixing mode of active components such as exosomes and drugs, and enhances the homogeneity and stability. The vascular stent prepared by using the active exosome stent coating of the application has reasonable sequential release kinetics design, can realize precise targeted regulation on human coronary artery smooth muscle cells (HCASMC) in vitro, does not affect the repair potential of endothelial cells, and solves the contradiction between traditional stents in terms of "anti-proliferation and promotion of healing".

This invention relates to a covered stent. Capable of radial collapse and expansion, it comprises a first occlusion portion, a stent middle layer, a second occlusion portion, and a support portion connected sequentially from a first end to a second end, and a covering membrane disposed in the first occlusion portion, the stent middle layer, and the second occlusion portion. The covering membrane serves to isolate blood flow. In the radially expanded state, because the outer diameter of the tubular stent middle layer is smaller than the outer diameters of the first and second occlusion portions, the covered stent is fixed to the blood vessel by the occlusion discs at both ends. The stent middle layer does not need to apply radial support force to the inner wall of the blood vessel for enhanced fixation, effectively avoiding tissue pressure. A support portion is provided at the second end of the second occlusion portion, and the outer diameter of the support portion is larger than the outer diameter of the second occlusion portion. The larger diameter effectively prevents the stent from being displaced towards the first end by blood flow, providing double protection for stent fixation.

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.

The utility model discloses a kind of vascular stents, belong to medical instrument field, including multiple intermediate rings, two end rings, first connecting tendon and second connecting tendon, multiple intermediate rings are evenly arranged along the axial direction of vascular stent, intermediate ring includes multiple first wave unit, two end rings are respectively arranged at the both ends of vascular stent, end ring includes multiple second wave unit, the both ends of first connecting tendon are connected with end ring and intermediate ring respectively, one end of first connecting tendon is connected with the end of second wave unit close to first wave unit, the other end of first connecting tendon is connected with the middle position of the crest and trough of first wave unit, the both ends of second connecting tendon are connected with two intermediate rings connected with each other respectively, and the end of second connecting tendon is connected in the middle position of the crest and trough of first wave unit. The embodiment of the application can reduce axial shortening, can optimize the mechanical distribution of end ring in expansion process, reduce the fracture of end ring and optimize stress distribution.

This invention relates to a vascular stent for the visceral region of the abdominal aorta, comprising an interconnected proximal non-degradable segment and a distal degradable segment. The proximal non-degradable segment includes a non-degradable metal skeleton and a covering structure. The distal degradable segment is a degradable bare skeleton. The proximal non-degradable segment corresponds to the location of the primary tear in the visceral region of the abdominal aorta, and the distal degradable segment corresponds to the location of branch vessels in the visceral region of the abdominal aorta. This invention is applicable to abdominal aortic dissection anatomical features, where the proximal stent segment is non-degradable and covered, while the distal visceral segment is degradable but not covered. It promotes false lumen thrombosis by sealing the primary tear through covering, while maintaining patency of branch vessels in the visceral segment by not covering. Simultaneously, a drug layer is attached to the covering of the proximal stent segment to actively promote intimal repair.

This application provides a method and system for in vivo stent orientation based on the principle of spatial reversal, relating to the field of vascular interventional technology. The method includes: during the advancement of a main stent delivery system carrying an integrated branch stent along an ultra-rigid guidewire towards the aortic arch, acquiring the orientation information of the delivery system and its contact force information with the vessel wall; then comparing the orientation information with a spatial reference path, and determining the entry point into the curved section of the aortic arch based on the comparison results; generating a reversal speed adjustment amount based on the deviation of the delivery system's orientation from the branch vessel opening direction, the vessel curvature, and the contact force information; finally, controlling the delivery system to rotate synchronously during advancement based on this adjustment amount, gradually adjusting the orientation of the branch stent from a preset position to directly facing the opening of the left subclavian artery, while dynamically adjusting the advancement speed according to the contact force information to maintain the contact force within a preset safe range. This application improves the accuracy and operational safety of in vivo stent orientation.

This invention discloses a method for preparing a biodegradable vascular stent, which overcomes the defects in the preparation process of vascular stents in the prior art. By setting a large-area sheet drop structure and introducing a redesigned sheet drop line, the problem of sheet drop difficulty is overcome. In addition, the prior art inevitably has the problem of multiple cuts in the same area. Since the laser itself has extremely high heat, passing through the same area will cause local burns. The vascular stent itself will be in direct contact with the blood vessel wall. This defect on the surface of the vascular stent may scratch the blood vessel during the expansion process, causing additional damage. Therefore, this application uses the boundary line between the sheet drop and the stent as the cutting path and additionally sets the entry point to avoid the burn problem caused by repeated local cutting.

This invention belongs to the field of medical materials technology, specifically relating to a bioresorbable corrosion-resistant magnesium alloy cardiovascular stent and its preparation method. This invention, through multi-element microalloying design, introduces specific types and amounts of alloying elements (such as Zn, Ca, Sr, Mn, and Nd) to synergistically regulate the electrode potential and microstructure of the alloy while ensuring biocompatibility. It also provides matching precision plastic processing and post-processing techniques. Through grain refinement, texture optimization, and surface modification, excellent radial support strength is achieved while simultaneously realizing controllable degradation rate and uniform degradation pattern. The results of the embodiments show that the corrosion reaction of the magnesium alloy cardiovascular stent of this invention occurs uniformly, solving the key problem of uniform degradation of biodegradable magnesium alloy stents.

This invention discloses a processing device for biodegradable magnesium alloy vascular stents, comprising a processing device body, tracks, a controller, and a transmission mechanism. The processing device body includes a polishing tank, a sandblasting tank, and a cleaning tank. Multiple transmission mechanisms are arranged between the tracks. Each transmission mechanism includes a transmission rod, a drive mechanism, and multiple positioning mechanisms. Rollers are provided at both ends of the transmission rod, and multiple racks and air holes are provided on the surface of the transmission rod. The drive mechanism includes a servo motor, a sub-control unit, and a transmission gear. The two ends of the transmission gear mesh with the servo motor and the rack, respectively. Each positioning mechanism includes a drive shaft and a cannula. The surface of the drive shaft meshes with the rack, and the cannula is rotatably inserted into the drive shaft. This invention enables continuous and batch sandblasting and electrochemical polishing of vascular stents, which not only improves production efficiency but also helps to reduce the production cost of vascular stents.

The application discloses a collagen anticorrosion coating with tissue repair performance, a preparation method and application, and belongs to the technical field of medical coatings. The application designs a novel self-repairing anticorrosion coating, and collagen is loaded on the coating through an excipient, so that the anticorrosion protection and biological function of the collagen anticorrosion coating are deeply integrated. The prepared collagen anticorrosion coating is firmly combined with a magnesium alloy substrate through a covalent bond, and no cracking and falling-off phenomenon occurs after being implanted in vivo for 4 weeks, the scaffold structure has good integrity, can provide sustained radial support, provides a sufficient time window for blood vessel repair, and provides a feasible scheme for clinical transformation of a new generation of biodegradable magnesium-based blood vessel stents.

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.

The application relates to the technical field of medical devices, and particularly discloses a vascular stent system, which comprises a shaft tube, a dilating balloon, a stent body and an anchoring balloon, wherein the dilating balloon is arranged at the distal end of the shaft tube, the stent body is arranged outside the dilating balloon, and the stent body can be expanded to be expanded along with the expansion of the dilating balloon; the anchoring balloon is arranged at the distal end of the shaft tube and is distributed on the distal end side of the dilating balloon; in the above scheme, the anchoring balloon can be first inflated and expanded to fix the whole vascular stent system, then the dilating balloon is controlled to expand the stent body, the stent body continuously supports the blood vessel after being shaped, the anchoring effect of the anchoring balloon can effectively resist the displacement caused by the blood vessel pulsation, the problems of stent body deviation, incomplete lesion coverage and postoperative displacement can be effectively eliminated, the operation difficulty is reduced, the implanting precision is improved, the complications are reduced, and the long-term treatment effect is guaranteed.

The application provides a blood vessel stent parameter determination method, an electronic device and a storage medium. The determination method comprises the following steps: segmenting a pre-acquired medical image to obtain a blood vessel mask image; obtaining a blood vessel center line corresponding to a blood vessel region of interest according to the blood vessel mask image; determining a cross section corresponding to each center point on the blood vessel center line according to the blood vessel mask image; and determining a diameter of a blood vessel stent corresponding to the blood vessel region of interest according to the cross section corresponding to each center point on the blood vessel center line. The application can accurately determine the parameters of the blood vessel stent, and effectively improves the diagnosis efficiency and accuracy.

This invention relates to a polishing fluid and polishing method for a medical zinc alloy vascular stent, belonging to the field of medical device metal polishing technology. The stent is made of zinc alloy, with zinc as the main component (greater than 95% by mass), and the remaining components being one or more of manganese, magnesium, copper, calcium, and lithium. The polishing fluid for the zinc alloy vascular stent is composed of acid and alcohol. The method is simple to operate and can achieve a relatively ideal polishing effect.

This utility model provides a quick-connect vascular stent, relating to the field of vascular stents. A quick-connect vascular stent includes a stent, a connecting seat, and a connector. The stent is fitted onto the outer wall of a first blood vessel; the connecting seat is fixed at the opening of a second blood vessel; the connector is installed between the connecting seat and the stent. The connector and the connecting seat cooperate to quickly fix the stent between the first and second blood vessels. Through the cooperation of the inner magnetic ring, outer magnetic ring, puncture needle, and base, fixation is achieved without sutures, allowing for rapid connection and fixation of the first and second blood vessels, reducing surgical time, and providing support at a specific angle through its shape.

The utility model relates to medical technology field discloses coronary artery spinous process balloon dilatation catheter, include: catheter seat, the one side of catheter seat is connected with outside pipe and installs, the other end fixed installation of outside pipe has the tip. In the utility model, the guide wire is sent into the first balloon until the narrow part, and the contrast medium or normal saline is injected into the first balloon by using the pressure injector at the same time, the first balloon is inflated, the coronary artery is dilated, in order to improve the adhesion of vascular stent and blood vessel inner wall, the doctor can suck back the contrast medium or normal saline in the first balloon, and repeatedly operates, can continuously extrude the plaque of blood vessel inner wall outward, after waiting operator sends into the second balloon until the narrow part through the guide wire again, and injects the contrast medium or normal saline into the second balloon, can make the vascular stent installed on the outer wall of second balloon expand to a larger extent, support in the blood vessel inner wall of patient, greatly improved the dilatation of patient blood vessel.

This invention relates to a recombinant hirudin fusion protein with collagen affinity, its preparation method, and its applications. The fusion protein is a recombinant hirudin fusion protein incorporating a collagen-binding domain (CBD). The fusion protein of this invention possesses affinity for type I and type III collagen, and can inhibit thrombin activity to exert an anticoagulant effect. Furthermore, it can bind well to collagen-based composite materials, making it suitable for use in cardiovascular implants such as heart valves, cardiac occluders, dialysis membranes, oxygenation membranes, artificial blood vessels, and vascular stents, as well as in extracorporeal circulation and blood purification devices, enhancing anticoagulant and antithrombotic effects.