168results about How to "Improve biological effect" patented technology

The invention relates to a probiotic combination comprising different combinations of lactobacilli. propionic acid bacteria and / or bifidobacteria. The probiotics are preferably combined with a suitable prebiotic to form a synbiotic. The combination of the invention can be consumed as such or combined with a suitable foodstuff or pharmaceutical product, and it is therapeutically useful for example for stimulating the immune system and for general health improvement.

Disclosed herein are stealthy polymeric biodegradable nanospheres each comprising: (i) a polyester-polyethylene multiblock copolymer; (ii) optionally a polyester entangled with the multiblock copolymer to give rigidity to the nanospheres; and (iii) optionally a pharmaceutical compound incorporated therein. Also disclosed is the use of such nanospheres for the preparation of a medicament having a long-term and non-toxic release of a pharmaceutical compound into a mammal, and the method for preparing a stealthy polymeric biodegradable nanospheres.

A novel liquid pesticide composition comprising a pesticidally active ingredient and a polyoxyethylene alkyl ether which has the following features (a) and (b): (a) an HLB value of 6 to 13.5; and (b) a content of 10 to 50 wt % based on the liquid pesticide composition.

A multifunctional sonic treating techinque for increasing the yield of plant and improving its quality and its sound wave generator are disclosed. The pulse modulated sound waves and sweep-frequency sound waves, which have strong force energy and information actions, are emitted toward the plant to promote the sequential activity of mass, energy and information, resulting in high yield and quality.

The cap is made into pyramid shape, and made use of the thin permanent magnet iron flake with intensity magnetic field. It can strengthen the effect of the biological magnetism of the human body and strengthen the human brain with magnetic field. This is a new type and practicable cap.

A lighting system for creating a biological effect induced by light. The biological effect is a different effect than vision. The lighting system comprises a light source (1) to generate light with a varying spectrum, and a driver (2) to drive the light source (1) to successively in time: (i) generate a first spectrum (S1) during a first period in time (T1), (ii) change the first spectrum (S1) into a second spectrum (S2) during a second period in time (T2), wherein the second spectrum (S2) has the biological effect, and (iii) maintain the second spectrum (S2) during a third period in time (T3). The duration of the second period in time (T2) is selected in a range from 5 seconds to 30 minutes. The first spectrum (S1) may not have the biological effect or may have the biological effect to a smaller extent than the second spectrum (S2).

The invention discloses compound platelet gel and a preparation method thereof. The preparation method includes: taking chitosan which is a natural material high in biodegradability and biocompatibility as a biological scaffold and a drug delivery carrier; activating fibrinogen in PRP to be a fibrin netty structure to be connected to chitosan molecules to form a gel carrier scaffold; and enabling platelet-derived cytokines to be adhered and anchored in the gel carrier scaffold to form the compound platelet gel. The compound platelet gel has multiple functions of quickly promoting tissue regeneration, bleeding stopping, bacterium resisting, pain relieving and humidity maintaining, and is simple to prepare, convenient to use, capable of realizing slow release of platelet-derived growth factors and active substances, lasting in biological effect and suitable for application in restorative treatment of soft or hard tissue defect, skin or mucosa refractory damage or ulcer, articular cartilage degeneration and ischemic tissue necrosis.

The invention provides a whitening composition inhibiting tyrosinase activities with multiple mechanisms and products of the composition, which relate to the field of chemicals for daily use. The whitening composition contains three active matters for inhibiting a tyrosinase active mechanism, and the three active matters include an active matter with competitive inhibition action, an active matter with noncompetitive inhibition action and an active matter with linear mixing competitive inhibition action. According to the invention, three inhibition mechanisms are used to obtain the novel inhibition composition, thus improving the enzyme inhibition efficacy of whitening effective substances and combinations, improving the biological effect of whitening, and reducing potential application irritation; the whitening composition is wide in coverage and relatively high in applicability, and has good whitening and freckle removing effects; and the whitening composition can be designed into essence, day cream, night cream, facial masks, facial cleansing milk and like products among cosmetic products.

A highly compact, high-performance volumetric imaging system is proposed, that is integrated with a multi-source Cobalt-60 gamma irradiator for high throughput, high accuracy and minimally invasive fractioned treatments of intracranial, orbital and head-and-neck targets.

A bioactive substance for conditioning human constitution and regulating immunity is prepared from cordyceps through extracting, filtering, concentrating, evaporating, spray drying, high-speed centrifugal filtering or diatomite filtering, and loading in capsules or preparing wine or oral liquid.

The invention discloses an 8-amino acid / 11-vitamin containing micro granule capsule and a preparation method thereof, wherein the micro granule capsule contains 7 ball micro granules consisting of the following raw materials in part by weight: 2.66-9.9 parts of thiamine mononitrate micro granule, 16.35-20.5 parts of vitamin micro granule a, 35.0-44.1 parts of amino acid micro granule a, 11.4-14.4 parts of vitamin micro granule b, 6.65-10.5 parts of amino acid micro granule b, 12.73-16.0 parts of vitamin C micro granule and 5.7-9.36 parts of vitamin AD micro bead. The method has the advantages of scientific and reasonable proportion, good stability of products, no toxicity and side effect and excellent biological effect, and can be used for the preparation of medicines treating chronic liver and kidney diseases and of food alleviating and eliminating physical fatigue caused by sports training.

The invention relates to selenium nano-particles and a preparation method thereof, in particular to amorphous selenium nano-particles with the grain diameter being 1-300 nm and a preparation method of the selenium nano-particles. The preparation method of the selenium nano-particles includes the steps that selenium combined macromolecules, a selenium source and a reducing agent or an oxidizing agent are subjected to a mixed reaction in a water phase medium, and nano-particles with the grain diameter being 1-300 nm are prepared; the selenium combined macromolecules are selected from water-soluble protein, water-soluble cellulose and water-soluble pectin and a combination of water-soluble protein, water-soluble cellulose and water-soluble pectin. According to the technical scheme, the nano selenium particles can be well stabilized, the nano selenium particles are not easily gathered into micron fine particles or larger selenium particles, and it is guaranteed that the nano selenium particles have good bioavailability and a good biological effect.

The invention relates to application of resveratrol-loading human multipotential stem cell exosome in preparing a drug for treating refractory healing skin wound related diseases. Compared with the prior art, embryonic stem cells and exosome inducing a human multipotential stem cell source are used as a drug carrier of the resveratrol, so that the biological effect of the resveratrol can be greatly improved; and by combining the function of the human multipotential stem cell exosome, the effect for treating the refractory healing skin wound related diseases can be greatly improved.

A yellow cordyceps wine for improving immunity and cardiovascular function, building up body, and delaying senility is prepared from the sporophore of northern cordyceps through extracting in hot water three times, collecting the liquid extract, centrifugal separation of dregs, collecting supernatant, film evaporating, concentrating, and proportionally mixing it with yellow wine.

The invention discloses a preparing method of an efficient straw decomposition agent, and belongs to the technical field of decomposition agent preparation. The preparing method includes the steps that thalli in rotted wood where mushroom grows are selected, enrichment culture is carried out on the thalli to obtain bacterium liquid, trichoderma atroviride microbial inoculum, bacillus subtilis microbial inoculum, saccharomyces cerevisiae microbial inoculum and bacillus thuringiensis microbial inoculum are activated on a slope, fermentation media are inoculated with the microbial inoculums and fermentation culture is performed respectively, all strain fermentation liquids are mixed to obtain a mixed fermentation liquid, the mixed fermentation liquid and the bacterium liquid are mixed and then concentrated, and an adsorbing carrier and the concentrated liquid are mixed to prepare the efficient decomposition agent. The prepared straw decomposition agent is high in decomposition speed and capable of completely degrading straw, promoting release of straw nutrient, improving the fertility improvement effect of soil with straw returning and improving the biological effect.

The invention relates to a agricultural chemicals branch of technology, specifically to an agriculture chemicals effervescence composition and a preparation method thereof.The invention discloses an agricultural chemicals effervescence composition comprising effervescence components, active compounds of agricultural chemicals, and the invention is characterized in that, taking the total weight as the basic reference, the agricultural chemicals effervescence composition also comprises the following components that water soluble base with a percentage by weight of 5-45% and water-soluble high molecular polymer with percentage by weight of 3-30% which form a united vector, and the active ingredients of agricultural chemicals are coated by the carrier to form a solid highly dispersed system.Every type of matters in the agricultural chemicals effervescence composition of the present invention has a better water-soluble performance, active compounds of agricultural chemicals can be highly dispersed into particles with a size of 0.001-0.1micrometre, the particle size of the active compounds of agricultural chemicals is much smaller than that of water-dispersion granulas, water dispersible powder and the like, the composition does not include any water-insoluble matters such as waterproofing agents, thinning agent and the like that are used by conventional effervescing agents, and once in water, the obtained effervescence composition is disintegrated instantly and rapidly and can be diffuse easily.Therefore, suspending particulate matters will never appear in the obtained solution, and if the prescription is reasonable, the solution will be clear and transparent; therefore, the composition can not only be used for expelling agriculture disease, but also be extensively used in the filed of expelling sanitation disease.

The invention relates to a compound amino acid capsule (8-11) and a preparation method thereof, specifically to a capsule including pellets of eight amino acids and eleven vitamins and a preparation method thereof. The capsule comprises 7 spherical pellets which are composed of the following raw materials by weight: 2.66 to 9.9 parts of a thiamine mononitrate pellet, 16.35 to 20.5 parts of a vitamin pellet a, 35.0 to 44.1 parts of an amino acid pellet a, 11.4 to 14.4 parts of a vitamin pellet b, 6.65 to 10.5 parts of an amino acid pellet b, 12. 73 to 16.0 parts of a vitamin C pellet and 5.7 to 9.36 parts of a vitamin AD bead. The capsule provided by the invention has the advantages of a scientific and reasonable ratio, good stability, no toxic and side effects, high security and good biological effects and can be applied in preparation of medicines used for treating chronic liver and kidney diseases and of foodstuffs used for alleviating and eliminating physical fatigue caused by exercise training. The capsule provided by the invention has characteristics superior to those of the prior art.

The invention relates to the technical field of biology, and provides an isolated culture method as well as freeze storage and recovery method of mesenchymal stem cells. The isolated culture method ofthe mesenchymal stem cell comprises the following steps: acquiring a primary cell of the mesenchymal stem cell; performing the culture amplification for the primary cell of the mesenchymal stem cell;and isolating the mesenchymal stem cell. By adopting the isolated culture method of the mesenchymal stem cell, the mesenchymal stem cell with good cell quality, safety and biological effect can be obtained. For the mesenchymal stem cell obtained by the isolated culture method of the mesenchymal stem cell, the invention also provides a freeze storage and recovery method of the mesenchymal stem cell, so that the mesenchymal stem cell can be well stored and recovered.

The invention relates to a human pluripotent stem cell exosome loaded with resveratrol, and a preparation method and an application thereof. The invention provides the following applications of a human pluripotent stem cell exosome and the human pluripotent stem cell exosome loaded with resveratrol: an application in preparation of medicines or cosmetics for preventing stretch marks, repairing stretch marks or treating stretch marks, an application in preparation of skin anti-aging medicines or cosmetics, and an application in preparation of medicines or cosmetics for treating skin scars, skinfreckles, pox, pimples, acne and the like. Compared with the prior art, the exosome derived from embryonic stem cells and induced human pluripotent stem cells is used as a drug carrier of resveratrol, the biological effect of resveratrol can be greatly improved, and with combination of the self function of the human pluripotent stem cell exosome, a better therapeutic effect on diseases can be played.

The invention discloses herbal tea containing L-arabinose. The herbal tea comprises the following ingredients according to weight percent: 0.002%-10% of L-arabinose, 0.02%-3% of D-xylose, 0.2%-8% of stachyose, 0-15% of cane sugar and 64%-99.773% of pure water, and a proper quantity of food additives can be further added into the herbal tea. The herbal tea can regulate blood sugar level, reduce blood fat and relieve lipogenesis, solves the problem that the conventional herbal tea with high sugar and heat and low nutrition is not suitable for people wth diabetes, adiposis and the like, has a function of gut purging to solve the problems of constipation and toxin accumulation of people, can further dispel the effects of alcohol to protect the liver so as to solve the problem that the liver is damaged as people drink too much alcohol, and therefore, the herbal tea is healthy food for preventing diabetes, loosing weight, relaxing the bowels and protecting liver.

A cationic liposome is proportionally prepared from DOPE, DOTMA and cholesterol and can be used to encapsulate the object (adenovirus carrier) to obtain a recombinant human endostatin adenovirus-cationic liposome composition carrying the active antineoplastic genes for suppressing the growth of tumor. Its preparing process is also disclosed.

The invention discloses a biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use. The preparation method comprises the following steps of mixing a solution containing Ca<2+> and Sr<2+> and a sodium dodecanesulphonate solution, dropwisely adding the mixed solution into an inorganic salt solution containing SO4<2-> continuously subjected to ultrasonic and stirring treatment so that strontium-doped calcium sulfate dehydrate particles are precipitated, carrying out filtration, washing and drying of the strontium-doped calcium sulfate dehydrate particles, heating at a temperature of 150 to 170 DEG C to obtain strontium-doped alpha-calcium sulfate hemihydrate particles, mixing the strontium-doped alpha-calcium sulfate hemihydrate particles and normal saline into paste according to a solid / liquid ratio of 0.5-2.0, and carrying out a hydration reaction and solidification formation process. The biodegradable strontium-doped calcium sulfate material having biological activity can be continuously degraded and release calcium, strontium and sulfate ions in a bone injury, and is suitable for drug slow release and healing of various human bone and tooth injuries. The preparation method has the characteristics of simple processes, and good controllability of particle morphology, particle sizes and a strontium doping ratio.

The invention discloses an enrichment method of platelet cell factor concentrates. The method comprises the steps as follows: whole blood is taken, platelets are collected, a cell suspension is prepared with normal saline, subjected to ultrasonic crushing multiple times under the ultrasonic power of 100-200 W and crushed for 1-60 s each time, a crushed mixed solution is filtered, filtrate is taken, and the platelet cell factor concentrates are obtained. The obtained platelet ultrasonic lysates (cell factor concentrates) comprise TGF-beta, PDGF, IGFs, FGFs, EGF, VEGF and the like, have multiple bioactivities, can increase cartilage cell activity of organisms and promote stem cells to proliferate and differentiate and contributes to regeneration and repair of cartilages and bone tissue. The composition can be prepared in the form of injection, powder and the like and has excellent application prospects in the medical bone tissue engineering field.

The invention relates to medical technology field, discloses a glucocorticoid synergist, and is characterized in adopting total ginsenoside as synergist. Its proportions are respectively as following: total ginsenoside 200mg-1200mg and dexamethasone 0.75-187.5mg; total ginsenoside 200mg-1200mg and betamethason 0.75-187.5mg; total ginsenoside 200-1200mg, and prednisone 5-1250mg, total ginsenoside 200-1200mg, and precortisyl 5-1250mg; total ginsenoside 200mg-1200mg, and urbason 4-1000mg; total ginsenoside 200-1200mg, and cortisone 25-6250mg; and total ginsenoside 200-1200mg, and hydrocortisone 20-5000mg.Total ginsenoside as glucocorticoid synergist can be used in the treatment of diseases requiring long term or a large amount of glucocorticoid such as systemic lupus erythematosus, nephrotic syndrome, polymyositis, and rheumatoid arthritis.

The present invention provides humanized antibodies that immunospecifically recognize human α9 integrin. Some of these antibodies inhibit the biological functions of the α9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with α9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

The invention relates to a conformal radiotherapy patch and a manufacturing method and application thereof. The conformal radiotherapy patch comprises a seal film, a support part, a protective material and a dosage monitoring and controlling device, wherein the support part is used for immobilizing radionuclides. The conformal radiotherapy patch is characterized in that the support part which immobilizes the radionuclides is sealed by the seal film and the protective material, the dosage monitoring and controlling device monitors and controls dosage of the radionuclides through pores of the protective material, a half-life period of the radionuclides is shorter than four days, and pure beta rays are adopted. Therefore, high compliance and conformality and short half-life period of the radionuclides are realized, continuous radiotherapy and precise monitoring and controlling are both achieved, and defects of existing radiopharmaceuticals in targeted continuous treatment and dosage control precision in treatment of skin diseases are improved.