95 results about "Volumetric imaging" patented technology

A method for aligning 3D objects in an extended reality (XR) system involves obtaining 3D objects from a volumetric imager or surface scanner, where the volumetric imager captures a three-dimensional voxel array representing an anatomical structure and the surface scanner generates a polygonal mesh or point cloud of the same structure. The method includes detecting a set of points on the 3D objects by identifying distinct anatomical landmarks, such as facial landmarks for soft tissue or tooth landmarks for hard tissue, and assigning each point a unique identifier. A video feed from XR goggles or a prerecorded video is obtained, providing real-time or prerecorded imagery of the patient's anatomical structure from various angles. Corresponding points on the video feed that align with the set of points detected on the 3D objects are identified using image processing techniques, ensuring accurate correspondence. The registered 3D objects are rendered to match the corresponding points on the patient's anatomical structure, with the alignment switching between soft tissue points when the patient's mouth is closed and hard tissue points when the patient's mouth is open for enhanced precision.

Methods and apparatus for quantifying an injected volume in an area of tissue during a medical procedure. In one example, a method includes determining a pixel-to-size scale parameter based on a pixelated image of a reference object included in a FOV of an optical instrument configured to perform volumetric imaging, the FOV further including an injection site; computing a first 3D model of the injected volume in the area of tissue based on a volumetric image of the FOV obtained using the optical instrument; refining the first 3D model to obtain a second 3D model of the injected volume, the refining including correcting a shape and a size of the first 3D model to reduce distortions associated with light refraction at a boundary of the injected volume in the area of tissue; and calculating a value of the injected volume based on the second 3D model and further based on the pixel-to-size scale parameter.

The present disclosure provides a methods and systems for analyzing one or more samples. The method may comprise using a plurality of sensors to substantially continuously integrate through a plurality of object planes of the sample. The integration can then generate a volumetric measurement of the sample.

Apparatuses and computer-implemented methods for compression and extraction of three-dimensional (3D) volumetric imaging data, including in particular medical and dental imaging data, that may receive the 3D volumetric image data and preparing compressed 3D volumetric image data for compression by analyzing a relevant region of the 3D volumetric image data. The method may further include compressing, into compressed 3D volumetric image data, the pre-processed static 3D volumetric image data using a video compression scheme. Various other methods, systems, and computer-readable media are also disclosed.

A modality for compressed light field measurement to capture 3D fluorescent signals at kilohertz volume rate, is described. This modality, termed Squeezed Light field Microscopy (SQLFM), acquires the light field with an array of rotated 2D sub-aperture images. An anamorphic relay system applies anisotropic scaling, effectively "squeezing" the image along one axis. This allows the camera sensor to detect the light field with a letterbox-shaped region of interest (ROI). Each squeezed sub-aperture image is complementary to the others, facilitating successful 3D reconstruction from compressed measurement while preserving the nominal FOV and spatial resolution. SQLFM can achieve over a fivefold increase in acquisition rate compared to traditional LFM.

The invention provides a system for image registration and volumetric imaging of a patient, the system comprising: a first interface adapted to receive 3D and / or 4D images of the patient; a second interface adapted to receive 2D images during a procedure carried out on the patient; and a processing unit wherein the processing unit is adapted to carry out a method comprising the steps of a method for image registration and volumetric imaging.

Disclosed herein are systems and methods for visualizing a target anatomical site of a patient using one or more imagers. The method can include placing multiple imagers on multiple locations at an anatomical site. The method can further include generating separate image data sets from the multiple images and combining the image data sets to generate a volumetric imaging data of the anatomical site. The volumetric imaging data can include all anatomical features within the target anatomical site. A visualization system for medical imaging can include transducers on the imagers to visualize the target anatomical site. The system can further include a processor to combine the image data sets to generate the volumetric imaging data set. The system can further include a display device to display the volumetric imaging data set.

The invention relates to the technical field of biomedical imaging, and discloses a photoacoustic-ultrasonic volume imaging method and system based on an annular ultrasonic array, and the method comprises the steps: reconstructing a two-dimensional photoacoustic image and a two-dimensional ultrasonic image; after photoacoustic imaging and ultrasonic synthetic aperture imaging of one imaging plane are completed, the annular ultrasonic array is moved in the direction perpendicular to the imaging plane, photoacoustic images and ultrasonic images of all the imaging planes are repeatedly executed on the next imaging plane, rebuilt and stacked, and a three-dimensional photoacoustic volume image and a three-dimensional ultrasonic volume image are formed; performing spatial pulse response deconvolution processing on the three-dimensional photoacoustic volume image; and fusing the processed three-dimensional photoacoustic volume image and the three-dimensional ultrasonic volume image to generate a three-dimensional bimodal volume image. According to the invention, high-time-resolution opto-acoustic-ultrasonic bimodal three-dimensional imaging is realized by using an annular ultrasonic array and motion scanning, and the high spatial resolution of the image is further ensured through a series of technologies.

The invention provides a femtosecond laser two-photon living body three-dimensional imaging system based on a super-long light needle adaptive depth of field, and relates to the technical field of two-photon microscopic imaging, the system comprises a femtosecond laser, a spatial light modulator (SLM), a scanning module and a signal acquisition module, wherein the SLM adopts a partition cooperative modulation mechanism of center pixel random phase distribution and peripheral pixel wavefront compensation, and phase distortion correction and scanning path synchronous control are realized by adjusting the pixel proportion of a dynamic balance center area and a compensation area and combining random distribution and a gradient descent optimization algorithm. Through random-deterministic phase collaborative modulation, dynamic depth-of-field matching and light path layered optimization, the limitation of axial resolution and speed of traditional two-photon microscopic imaging is broken through, millisecond-level three-dimensional volume imaging of a living body sample is achieved, and the temporal-spatial resolution detection capacity of the dynamic biological process is remarkably improved.

A volumetric imaging system implements obtaining raw image data of a sample volume of a sample material, the raw image data comprising light field data of the sample volume acquired using a microlens array disposed in front of a camera; and analyzing the raw image data using an image analysis pipeline configured to localize the objects of interest in the raw image data to obtain classified image data in which the objects of interest have been identified, the image analysis pipeline being configured to process the raw image data to improve signal extraction at depth in the scattering material to maximize localization accuracy.

Imaging devices are provided having a low-profile substrate structure with a mounting surface that can be removably placed on flat work surface. Further, a low-profile frame structure coincides with a peripheral region of that substrate structure and contains a plurality of imagers, at least some of which are on opposing sides of the substrate structure. The opposing imagers are positioned such that the respective fields of view are inwardly facing toward a central region of an upper surface and define a scan volume extending across the substrate structure and above the central region. The upper and lower bounds of the imaging device form a low-profile assembly generally accessible to scan objects moving across any direction.

An imaging element may include volume Bragg grating (VBG) within a material, where the material has an input face, and where the VBG is formed as a periodic distribution of curved surfaces of refractive index variation with chirped periodicity in a volume of the material. The periodic distribution of curved surfaces of refractive index variation forming the VBG may be selected to image different object planes oriented parallel to the input face onto different lateral locations of a single image plane with different wavelengths via the Bragg diffraction.

A system and method for generating canonical views for volumetric imaging data are disclosed. The system includes at least a processor and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to receive volumetric imaging data, segment the at least one organ structure of the volumetric imaging data into a plurality of organ components, compute, for each organ component, one or more eigenvectors and corresponding eigenvalues, divide each organ component into a plurality of three-dimensional octants, receive a user input, wherein the user input includes a selection of a reference field of view, determine which of the plurality of three-dimensional octants are intersected by the reference field of view and output the volumetric imaging data with the canonical view.

Aspects of the present disclosure include systems and methods for planning and / or performing ablation procedures. Volumetric image data including a needle, such as a tangible ablation needle or a virtual needle, may be analyzed to divide the needle within the volume. A first cross-sectional two-dimensional view of the volume can be generated and displayed showing a first plane on which the axis defined by the needle is located. The view may be manipulated to display a second cross-sectional two-dimensional view of the generated volume, the two-dimensional view showing a second plane through the volume where the longitudinal axis defined by the virtual needle lies, the second plane being different from the first plane. Other partitioned features such as lesions, treatment regions, isotherms, etc. in the image data may be included in views for analysis from multiple views including needles.

A method for automated steering of magnetically steerable intravascular guidewires includes accessing, by a magnetic steering control component, volumetric imaging associated with a patient. The magnetic steering control component generates, prior to an operation on the patient, a three-dimensional vessel map based, upon the accessed volumetric imaging. The magnetic steering control component generates, prior to the operation, a path through a vasculature of the patient. The magnetic steering control component displaying, prior to the operation, in a. graphical user interface, the three-dimensional vessel map and the path. The magnetic steering control component receives input representing a modification to the path and modifies the path based upon the received input. The magnetic steering control component directs, during the operation, at least one of a medical robot arm and a motorized, guidewire advancing unit to modify a location of a magnetically steerable intravascular guidewire in accordance with the modified path.

The invention provides a real-time 4D-CBCT imaging method based on a Unet-Transform model, and the method comprises the steps: constructing a comprehensive cascade deep learning network model integrating a Unet network and a Transform network, training the network model, inputting a plurality of CBCT projections containing different respiratory movement amplitudes, which are collected at the same rack angle at the online treatment moment of a patient, into the trained network model, the model outputs three PCA feature tags of a DVF between a predicted phase of breathing motion of a patient at the current moment and a reference phase corresponding to CBCT projection in real time, the PCA feature tags are converted into the DVF through principal component analysis, a reference phase image of an earlier-stage 4D-CT of the patient is deformed under the guidance of the DVF, a corresponding 4D-CBCT image of the breathing phase at the current moment is obtained, and the CBCT image of the breathing motion of the patient at the current moment is obtained. And finally, a 4D-CBCT image sequence capable of covering a complete respiratory cycle is obtained. According to the method, dynamic volume imaging is carried out on the patient during SBRT fractional treatment beam exiting by utilizing a Unt-Transform network model framework, a tool for accurately monitoring movement of tumors in the lung during beam exiting treatment of the patient is provided for clinicians, and technical guarantee is provided for accurate and safe implementation of the lung cancer SBRT.

A method of generating annotations corresponding to objects within images based on neural networks iteratively trained using the images. Active learning is used to train a machine learning model 256 b

The invention discloses a squint field three-dimensional chromatography microscopic imaging device and application thereof. The apparatus comprises: an illumination system for providing mode illumination light having an initial mode illumination surface; the imaging system is used for detecting the fed-back signal light; the light path system is used for projecting the mode illumination light and feeding back and transmitting the signal light, and the initial mode illumination surface forms an inclined excitation surface after passing through the light path system; and the scanning system is used for driving to generate scanning relative motion between the inclined excitation surface and the sample to be observed. According to the invention, optical tomography is carried out on the inclined field of view by means of mode illumination, and three-dimensional scanning is realized by driving the lateral displacement of the inclined field of view relative to an imaging sample; the optical tomography three-dimensional microscopic imaging can be efficiently and quickly implemented without zooming or axially mechanically moving the objective lens or the sample to be observed, the volume imaging rate is remarkably improved, the system design is simplified, the system stability and robustness are enhanced, and an innovative solution is added to the field of three-dimensional microscopic imaging.

The disclosure relates to photocleavable crosslinkers that are suitable for preparing photodegradable hydrogels and to methods for volumetric imaging of biological specimens by photochemical sectioning and imaging of photodegradable hydrogels. A photocleavable crosslinker according to the disclosure can include one or more water-soluble hydrocarbon linkers, two or more reactive functional groups such as ethylenically unsaturated groups, and one or more photocleavable groups. A crosslinked hydrogel can be formed between the photocleavable crosslinker and other hydrogel monomers. The crosslinked hydrogel can be used as a matrix immobilize a biological or other sample material in a hydrogel composite. The hydrogel composite and the sample material therein can be volumetric imaged by sequentially and repeatedly optically imaging an image layer of the hydrogel composite and then photochemically sectioning a depolymerization layer of the hydrogel composite.

An apparatus for volumetric imaging is provided. The apparatus comprises an illumination assembly arranged to direct light to illuminate a plurality of planes in a sample region sequentially at an illumination rate, each plane extending over a plurality of depths in the sample region; an image sensor comprising a plurality of sections of pixels and arranged to sense each section of pixels sequentially at a sensing rate; and a light-receiving assembly arranged to receive light from the sample region and to direct light received from each of said planes in the sample region to a different respective section of said sections of pixels. The light-receiving assembly comprises a multi-plane optical assembly arranged to receive light from the plurality of depths in the sample region and, for each section of said sections of pixels, to direct light simultaneously from each of the plurality of depths in the respective plane to a different respective subsection of said section. The illumination rate is equal to the sensing rate, such that each section of pixels is arranged to sense light from the plurality of depths in the respective plane as the plane is illuminated by the illumination assembly.

Volume-of-interest (“VOI”) imaging with computed tomography (“CT”) (e.g., VOI CT in a helical or axial acquisition geometry) is used to produce higher resolution, lower noise images with less radiation dose than is required for equivalent resolution and noise characteristics using standard data acquisitions. Truncation artifacts introduced by the VOI imaging are removed or otherwise reduced using a deep learning model that is trained to remove truncation artifacts from VOI images.

Lymphatic, nervous, and tumoral tissues, among others, exhibit physiology that emerges from three-dimensional interactions between genetically unique cells. A technology capable of volumetrically imaging genotypes and morphologies in a single de novo measurement would therefore provide a critical view into the biological complexity of living systems. The present disclosure achieves this by extending DNA microscopy, an imaging modality that encodes a spatio-genetic map of a specimen via a massive distributed network of DNA molecules inside it, to three dimensions and multiple length scales in developing zebrafish embryos.

A medical imaging communication system processes medical images for being transmitted to a client device. The system receives a set of images, each image corresponding to a slice of a three-dimensional object. The system combines a first subset of the images into a first combined image and combines a second subset of the images into a second combined image. The first and second combined image are compressed using a lossless compression algorithm and transmitted to the client device.

Embodiments are provided for improved analysis of surgically explanted pathology samples or other varieties of tissue sample by guiding the sectioning of those samples using high-resolution volumetric imaging data. Such imaging data can include micro-CT imaging data. Improved sample imaging and visualization methods facilitate pathological analysis of the sample, guiding the sectioning of the sample to planes most likely to provide highly valuable and accurate data about sample margins relative to tumors or other target structures, tissue type cell morphology or other properties of a tumor or other target structure, or other clinically relevant data that could be missed were the tissue sample not sectioned along such image-guided plane(s). A projector or augmented-reality device can be used to indicate, to a pathologist, the location of structures of interest within the sample and / or the location of a sectioning gig could be detected / controlled relative to a display of the imaging data.

A volumetric imaging data processing apparatus comprising processing circuitry configured to receive first volume data comprising a plurality of first samples, generate second volume data based on the first volume data, the second volume data comprising a plurality of second samples, a number of the plurality of second samples being less than a number of the plurality of first samples and each of the plurality of second samples of the second volume data having a corresponding first sample of the first volume data, generate adjusted second volume data comprising a plurality of adjusted second regions, each adjusted second region being generated by performing a number of iterations of adjusting a voxel value of a second sample in a second region of the second volume data, wherein in each of the number of iterations, the processing circuitry is configured to determine a plurality of differences between a plurality of first opacity values in a first region of the first volume data and a plurality of corresponding second opacity values in the second region, and adjust the voxel value of the second sample in the second region based on a weighted sum of the plurality of differences.

A method of obtaining measurements of semiconductor structures on a wafer comprises: obtaining a volumetric imaging dataset of the wafer comprising multiple 2D cross section images; obtaining contours of semiconductor structures in 2D cross section images; indicating, in a first 2D cross section image, one or more measurement specifications with respect to features of contours of semiconductor structures; propagating the indicated one or more measurement specifications in the first 2D cross section image to further 2D cross section images; and obtaining measurements of semiconductor structures by evaluating the one or more measurement specifications in the first 2D cross section image and in the further 2D cross section images.

High-speed volumetric imaging is useful for observing fast and distributed processes such as neuronal activity. Multiphoton microscopy helps to mitigate scattering effects inside tissue, but the standard raster scanning approach limits achievable volume rates. Random-access scanning can lead to a considerable speed-up by sampling pre-selected locations; however, existing techniques based on acousto-optic deflectors may still be limited to a point rate that is low. This limitation may restrict the number of parallel targets at the high acquisition rates necessary, for example, in voltage imaging or imaging of fast synaptic events. Disclosed herein is a method for three-dimensional (3D) random-access scanning at up to 340 kHz rate using a single 1D phase modulator in a compact setup. The potential of this method is demonstrated by imaging synaptic events with fluorescent glutamate sensors in mammalian organotypic slices as well as in zebrafish larvae.

Imaging devices are provided having a low-profile substrate structure with a mounting surface that can be removably placed on flat work surface. Further, a low-profile frame structure coincides with a peripheral region of that substrate structure and contains a plurality of imagers, at least some of which are on opposing sides of the substrate structure. The opposing imagers are positioned such that the respective fields of view are inwardly facing toward a central region of an upper surface and define a scan volume extending across the substrate structure and above the central region. The upper and lower bounds of the imaging device form a low-profile assembly generally accessible to scan objects moving across any direction.

The invention relates to a method (10) for obtaining a measurement of a semiconductor structure (30) on a wafer (72), comprising: obtaining a volumetric imaging data set (22) of the wafer (72), comprising a plurality of 2D profile images (24, 26); obtaining a contour (32) of the semiconductor structure (30) in the 2D profile image (24, 26); one or more measurement specifications (28) indicating features in the first 2D cross-sectional image (24) with respect to a contour (32) of the semiconductor structure (30); propagating the one or more measurement specifications (28) indicated in the first 2D profile image (24) to a further 2D profile image (26); and obtaining a measurement of the semiconductor structure (30) by evaluating one or more measurement specifications (28) in the first 2D profile image (24) and the further 2D profile image (26).