58 results about "Volumetric imaging" patented technology

The present disclosure provides a methods and systems for analyzing one or more samples. The method may comprise using a plurality of sensors to substantially continuously integrate through a plurality of object planes of the sample. The integration can then generate a volumetric measurement of the sample.

A modality for compressed light field measurement to capture 3D fluorescent signals at kilohertz volume rate, is described. This modality, termed Squeezed Light field Microscopy (SQLFM), acquires the light field with an array of rotated 2D sub-aperture images. An anamorphic relay system applies anisotropic scaling, effectively "squeezing" the image along one axis. This allows the camera sensor to detect the light field with a letterbox-shaped region of interest (ROI). Each squeezed sub-aperture image is complementary to the others, facilitating successful 3D reconstruction from compressed measurement while preserving the nominal FOV and spatial resolution. SQLFM can achieve over a fivefold increase in acquisition rate compared to traditional LFM.

The invention provides a system for image registration and volumetric imaging of a patient, the system comprising: a first interface adapted to receive 3D and / or 4D images of the patient; a second interface adapted to receive 2D images during a procedure carried out on the patient; and a processing unit wherein the processing unit is adapted to carry out a method comprising the steps of a method for image registration and volumetric imaging.

The invention relates to the technical field of biomedical imaging, and discloses a photoacoustic-ultrasonic volume imaging method and system based on an annular ultrasonic array, and the method comprises the steps: reconstructing a two-dimensional photoacoustic image and a two-dimensional ultrasonic image; after photoacoustic imaging and ultrasonic synthetic aperture imaging of one imaging plane are completed, the annular ultrasonic array is moved in the direction perpendicular to the imaging plane, photoacoustic images and ultrasonic images of all the imaging planes are repeatedly executed on the next imaging plane, rebuilt and stacked, and a three-dimensional photoacoustic volume image and a three-dimensional ultrasonic volume image are formed; performing spatial pulse response deconvolution processing on the three-dimensional photoacoustic volume image; and fusing the processed three-dimensional photoacoustic volume image and the three-dimensional ultrasonic volume image to generate a three-dimensional bimodal volume image. According to the invention, high-time-resolution opto-acoustic-ultrasonic bimodal three-dimensional imaging is realized by using an annular ultrasonic array and motion scanning, and the high spatial resolution of the image is further ensured through a series of technologies.

The invention provides a femtosecond laser two-photon living body three-dimensional imaging system based on a super-long light needle adaptive depth of field, and relates to the technical field of two-photon microscopic imaging, the system comprises a femtosecond laser, a spatial light modulator (SLM), a scanning module and a signal acquisition module, wherein the SLM adopts a partition cooperative modulation mechanism of center pixel random phase distribution and peripheral pixel wavefront compensation, and phase distortion correction and scanning path synchronous control are realized by adjusting the pixel proportion of a dynamic balance center area and a compensation area and combining random distribution and a gradient descent optimization algorithm. Through random-deterministic phase collaborative modulation, dynamic depth-of-field matching and light path layered optimization, the limitation of axial resolution and speed of traditional two-photon microscopic imaging is broken through, millisecond-level three-dimensional volume imaging of a living body sample is achieved, and the temporal-spatial resolution detection capacity of the dynamic biological process is remarkably improved.

A volumetric imaging system implements obtaining raw image data of a sample volume of a sample material, the raw image data comprising light field data of the sample volume acquired using a microlens array disposed in front of a camera; and analyzing the raw image data using an image analysis pipeline configured to localize the objects of interest in the raw image data to obtain classified image data in which the objects of interest have been identified, the image analysis pipeline being configured to process the raw image data to improve signal extraction at depth in the scattering material to maximize localization accuracy.

A system and method for generating canonical views for volumetric imaging data are disclosed. The system includes at least a processor and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to receive volumetric imaging data, segment the at least one organ structure of the volumetric imaging data into a plurality of organ components, compute, for each organ component, one or more eigenvectors and corresponding eigenvalues, divide each organ component into a plurality of three-dimensional octants, receive a user input, wherein the user input includes a selection of a reference field of view, determine which of the plurality of three-dimensional octants are intersected by the reference field of view and output the volumetric imaging data with the canonical view.

A method for automated steering of magnetically steerable intravascular guidewires includes accessing, by a magnetic steering control component, volumetric imaging associated with a patient. The magnetic steering control component generates, prior to an operation on the patient, a three-dimensional vessel map based, upon the accessed volumetric imaging. The magnetic steering control component generates, prior to the operation, a path through a vasculature of the patient. The magnetic steering control component displaying, prior to the operation, in a. graphical user interface, the three-dimensional vessel map and the path. The magnetic steering control component receives input representing a modification to the path and modifies the path based upon the received input. The magnetic steering control component directs, during the operation, at least one of a medical robot arm and a motorized, guidewire advancing unit to modify a location of a magnetically steerable intravascular guidewire in accordance with the modified path.

The invention provides a real-time 4D-CBCT imaging method based on a Unet-Transform model, and the method comprises the steps: constructing a comprehensive cascade deep learning network model integrating a Unet network and a Transform network, training the network model, inputting a plurality of CBCT projections containing different respiratory movement amplitudes, which are collected at the same rack angle at the online treatment moment of a patient, into the trained network model, the model outputs three PCA feature tags of a DVF between a predicted phase of breathing motion of a patient at the current moment and a reference phase corresponding to CBCT projection in real time, the PCA feature tags are converted into the DVF through principal component analysis, a reference phase image of an earlier-stage 4D-CT of the patient is deformed under the guidance of the DVF, a corresponding 4D-CBCT image of the breathing phase at the current moment is obtained, and the CBCT image of the breathing motion of the patient at the current moment is obtained. And finally, a 4D-CBCT image sequence capable of covering a complete respiratory cycle is obtained. According to the method, dynamic volume imaging is carried out on the patient during SBRT fractional treatment beam exiting by utilizing a Unt-Transform network model framework, a tool for accurately monitoring movement of tumors in the lung during beam exiting treatment of the patient is provided for clinicians, and technical guarantee is provided for accurate and safe implementation of the lung cancer SBRT.

The invention discloses a squint field three-dimensional chromatography microscopic imaging device and application thereof. The apparatus comprises: an illumination system for providing mode illumination light having an initial mode illumination surface; the imaging system is used for detecting the fed-back signal light; the light path system is used for projecting the mode illumination light and feeding back and transmitting the signal light, and the initial mode illumination surface forms an inclined excitation surface after passing through the light path system; and the scanning system is used for driving to generate scanning relative motion between the inclined excitation surface and the sample to be observed. According to the invention, optical tomography is carried out on the inclined field of view by means of mode illumination, and three-dimensional scanning is realized by driving the lateral displacement of the inclined field of view relative to an imaging sample; the optical tomography three-dimensional microscopic imaging can be efficiently and quickly implemented without zooming or axially mechanically moving the objective lens or the sample to be observed, the volume imaging rate is remarkably improved, the system design is simplified, the system stability and robustness are enhanced, and an innovative solution is added to the field of three-dimensional microscopic imaging.

The disclosure relates to photocleavable crosslinkers that are suitable for preparing photodegradable hydrogels and to methods for volumetric imaging of biological specimens by photochemical sectioning and imaging of photodegradable hydrogels. A photocleavable crosslinker according to the disclosure can include one or more water-soluble hydrocarbon linkers, two or more reactive functional groups such as ethylenically unsaturated groups, and one or more photocleavable groups. A crosslinked hydrogel can be formed between the photocleavable crosslinker and other hydrogel monomers. The crosslinked hydrogel can be used as a matrix immobilize a biological or other sample material in a hydrogel composite. The hydrogel composite and the sample material therein can be volumetric imaged by sequentially and repeatedly optically imaging an image layer of the hydrogel composite and then photochemically sectioning a depolymerization layer of the hydrogel composite.

Volume-of-interest (“VOI”) imaging with computed tomography (“CT”) (e.g., VOI CT in a helical or axial acquisition geometry) is used to produce higher resolution, lower noise images with less radiation dose than is required for equivalent resolution and noise characteristics using standard data acquisitions. Truncation artifacts introduced by the VOI imaging are removed or otherwise reduced using a deep learning model that is trained to remove truncation artifacts from VOI images.

A medical imaging communication system processes medical images for being transmitted to a client device. The system receives a set of images, each image corresponding to a slice of a three-dimensional object. The system combines a first subset of the images into a first combined image and combines a second subset of the images into a second combined image. The first and second combined image are compressed using a lossless compression algorithm and transmitted to the client device.

Embodiments are provided for improved analysis of surgically explanted pathology samples or other varieties of tissue sample by guiding the sectioning of those samples using high-resolution volumetric imaging data. Such imaging data can include micro-CT imaging data. Improved sample imaging and visualization methods facilitate pathological analysis of the sample, guiding the sectioning of the sample to planes most likely to provide highly valuable and accurate data about sample margins relative to tumors or other target structures, tissue type cell morphology or other properties of a tumor or other target structure, or other clinically relevant data that could be missed were the tissue sample not sectioned along such image-guided plane(s). A projector or augmented-reality device can be used to indicate, to a pathologist, the location of structures of interest within the sample and / or the location of a sectioning gig could be detected / controlled relative to a display of the imaging data.

A volumetric imaging data processing apparatus comprising processing circuitry configured to receive first volume data comprising a plurality of first samples, generate second volume data based on the first volume data, the second volume data comprising a plurality of second samples, a number of the plurality of second samples being less than a number of the plurality of first samples and each of the plurality of second samples of the second volume data having a corresponding first sample of the first volume data, generate adjusted second volume data comprising a plurality of adjusted second regions, each adjusted second region being generated by performing a number of iterations of adjusting a voxel value of a second sample in a second region of the second volume data, wherein in each of the number of iterations, the processing circuitry is configured to determine a plurality of differences between a plurality of first opacity values in a first region of the first volume data and a plurality of corresponding second opacity values in the second region, and adjust the voxel value of the second sample in the second region based on a weighted sum of the plurality of differences.

A method of obtaining measurements of semiconductor structures on a wafer comprises: obtaining a volumetric imaging dataset of the wafer comprising multiple 2D cross section images; obtaining contours of semiconductor structures in 2D cross section images; indicating, in a first 2D cross section image, one or more measurement specifications with respect to features of contours of semiconductor structures; propagating the indicated one or more measurement specifications in the first 2D cross section image to further 2D cross section images; and obtaining measurements of semiconductor structures by evaluating the one or more measurement specifications in the first 2D cross section image and in the further 2D cross section images.

Imaging devices are provided having a low-profile substrate structure with a mounting surface that can be removably placed on flat work surface. Further, a low-profile frame structure coincides with a peripheral region of that substrate structure and contains a plurality of imagers, at least some of which are on opposing sides of the substrate structure. The opposing imagers are positioned such that the respective fields of view are inwardly facing toward a central region of an upper surface and define a scan volume extending across the substrate structure and above the central region. The upper and lower bounds of the imaging device form a low-profile assembly generally accessible to scan objects moving across any direction.

The invention relates to a method (10) for obtaining a measurement of a semiconductor structure (30) on a wafer (72), comprising: obtaining a volumetric imaging data set (22) of the wafer (72), comprising a plurality of 2D profile images (24, 26); obtaining a contour (32) of the semiconductor structure (30) in the 2D profile image (24, 26); one or more measurement specifications (28) indicating features in the first 2D cross-sectional image (24) with respect to a contour (32) of the semiconductor structure (30); propagating the one or more measurement specifications (28) indicated in the first 2D profile image (24) to a further 2D profile image (26); and obtaining a measurement of the semiconductor structure (30) by evaluating one or more measurement specifications (28) in the first 2D profile image (24) and the further 2D profile image (26).

A method for automated steering of magnetically steerable intravascular guidewires includes accessing, by a magnetic steering control component, volumetric imaging associated with a patient. The magnetic steering control component generates, prior to an operation on the patient, a three-dimensional vessel map based upon the accessed volumetric imaging. The magnetic steering control component generates, prior to the operation, a path through a vasculature of the patient. The magnetic steering control component displaying, prior to the operation, in a graphical user interface, the three-dimensional vessel map and the path. The magnetic steering control component receives input representing a modification to the path and modifies the path based upon the received input. The magnetic steering control component directs, during the operation, at least one of a medical robot arm and a motorized guidewire advancing unit to modify a location of a magnetically steerable intravascular guidewire in accordance with the modified path.

The invention provides an optical volume imaging system based on optical chain illumination. The system comprises an optical chain generation module, a scanning focusing module, a sample control module, a fluorescence signal detection module and a microscopic imaging processing terminal, the optical chain generation module is used for generating and emitting an optical chain; the scanning focusing module is used for focusing a light chain; the sample control module is used for bearing a sample and adjusting the position of the sample; the fluorescence signal detection module is used for separating and detecting a fluorescence signal generated after the sample is excited by the light chain and converting the fluorescence signal into an electric signal; and the microscopic imaging processing terminal is used for acquiring electric signals and controlling the scanning speed of the scanning device, the Z-axis displacement of the objective lens and the gain of the photomultiplier tube through a closed loop so as to realize synchronous acquisition and reconstruction of three-dimensional volume data of the sample. The system provided by the invention has high spatial-temporal resolution and excellent imaging depth in a living scene, and provides a reliable optical imaging platform for long-time and high-throughput dynamic observation.

An exemplary embodiment of the present disclosure provides a method of imaging skin to obtain information on dermal lesions, comprising: providing a quantitative oblique back- illumination microscopy (qOBM) system; and volumetrically imaging, with the qOBM system, at least a portion of skin of a subject in vivo.

A system and a method for imaging are provided for using in high-throughput imaging of bio-specimens, including, for example but not limited to, movements of bacteria or a colloidal suspension, and tracking of microscopic living organisms or particles. The system and method may be used for generating a volumetric image of a sample by combining holographic and fluorescence imaging techniques as disclosed herein. The system and method may include obtaining, via an optical imaging system, a fluorescence image and a digital hologram of a sample comprising one or more objects; generating a two-dimensional depth map of the one or more objects based on the digital hologram; correlating the two-dimensional depth map of the one or more objects with the fluorescence image of the sample; and generating a volumetric image of the one or more objects in a three-dimensional volume.

The present disclosure provides a methods and systems for analyzing one or more samples. The method may comprise using a plurality of sensors to substantially continuously integrate through a plurality of object planes of the sample. The integration can then generate a volumetric measurement of the sample.

An imaging method and an associated imaging system (100, 200) are disclosed herein. The imaging method comprises:-providing an array of light sources, each source being configured for the output of a light emission,-providing an imaging unit (2) comprising a focusing element (L0) and a detector (DT), the detector being configured to detect the light emission 10 from the sources of the array by means of the focusing element (L0),-providing an object (OBJ) between the detector (DT) and the array of light sources, providing an imaging device (IL, FFL) 15 between the array of light sources and the object (OBJ), -operating the array of light sources (SRC ') by activating the light sources according to a sequence pattern, whereby, according to said sequence pattern, the position of the activated light sources in the array relative to the 20 object (OBJ) varies with the activation of the light sources,-imaging the array of light sources by said imaging device (IL, FFL) while operating the array of light sources 25, detecting, by 30 imaging devices (IL, FFL) and by focusing elements (L0), on said detector (DT), the spatial positions of images (I1-In) of points of said object (OBJ) formed at different positions of the activated light sources in the array, and the offset (O1-On) 27, 27, 27 ') of each detected spatial position with respect to a reference spatial position (x); -reconstructing an image of the object (OBJ) by aligning images of points of said object (OBJ) formed at different positions of the activated light sources in the array by deviating from each detected spatial position from a reference spatial position (x).

The invention discloses a high-flux super-resolution volume imaging method for axial position information recovery, which comprises the following steps of: firstly, configuring a femtosecond excitation light source and a nanosecond loss light source, and then modulating phases of two light beams through a spatial light modulator to change the beat frequency coding axial position of excitation Bessel light drops; the loss light is endowed with first-order orbital angular momentum to realize depth-of-field hollow transmission; then the two light beams are subjected to spatial coincidence and time synchronization output, a resonance mirror and a current detection mirror are used for conducting two-dimensional rapid scanning on the combined light beam, focusing fluorescent molecules to induce the stimulated radiation loss effect and compressing the size of the fluorescent molecules so as to achieve volume super-resolution imaging in the focal depth range, finally, inverse Fourier transformation is conducted on an imaging picture stack to reconstruct the position, and axial information is extracted. According to the method, the influence of side lobes on the resolution and the signal-to-noise ratio can be reduced, high-contrast and rapid super-resolution volume imaging of organelles is achieved, and in the volume of 10 microns * 10 microns * 10 microns, the transverse resolution is superior to 100 nm, and the axial resolution reaches 1 micron.

A microscopy method for volumetric imaging of a sample located within an object space, comprising: obtaining a set of lightfield images using a lightfield detection apparatus, each associated with an illumination slice corresponding to a lightsheet projected into the object space from a particular illumination position and at an illumination angle non-parallel to an optical axis of the lightfield detection apparatus, such that each voxel of a set of voxels associated with the object space is illuminated by at least one illumination slice, wherein each voxel is defined by a position in the object space; and determining, for each voxel, an intensity of light emitted from the object space associated with said voxel using, in part, angular information captured by the lightfield images, such that the determined intensities for each voxel of the set of voxels defines a volumetric image of emitted light intensity within the object space, and associated system.

Systems and methods are provided for improved intra-operative micro-CT imaging of explanted tissue samples and for improved visualization of such samples. These embodiments provide for reduced scan times and the ability for radiologists to quickly receive useful scan imagery and to provide accurately-communicated recommendations to the operating surgeon. Improved scan visualization methods facilitate surgeon and radiologist interaction with the scan data, including of annotation, viewing, and re-orientation to accurately reflect the orientation of imaged tissue samples relative to the body prior to explantation. Improved visualization methods include color-coded sample texturing to indicate sample orientation, color-coded tumor visualization to indicate proximity to sample margins, and intuitive methods for adjusting the location and orientation of two-dimensional visualizations relative to the sample.

The application relates to the technical field of ultrasonic three-dimensional imaging, and provides a three-dimensional full-focusing imaging method based on a row-column addressing ultrasonic probe, wherein according to the spatial position of an array element of the row-column addressing ultrasonic probe, the imaging area range and the imaging pixel size, the propagation flight time of each pixel point in a three-dimensional space to each array element is calculated; a first group of three-dimensional full-matrix data is acquired by row-by-row excitation and emission of row array elements and by receiving echo signals by column array elements; a second group of three-dimensional full-matrix data is obtained by column-by-column excitation and emission of column array elements and by receiving echo signals by row array elements; and the first group of three-dimensional full-matrix data and the second group of three-dimensional full-matrix data are processed by a three-dimensional full-focusing algorithm based on the total propagation flight time of each pixel point to each array element, so that a three-dimensional volume image of a measured structure is obtained. Under the premise of reducing the system channel number and the hardware complexity, high-resolution and high-quality three-dimensional volume imaging is realized, and the method has good engineering realizability and popularization potential.

The application discloses a helical line multi-point amplification sampling photoacoustic volume imaging method and system, and belongs to the technical field of photoacoustic volume imaging. In step S1, signal amplification training data set is acquired; the imaging area of a biological tissue or a phantom sample is adjusted to be located in a set sound field range of a three-dimensional bowl-shaped ultrasonic array, three-dimensional photoacoustic volume imaging is performed on the biological tissue or the phantom sample to obtain non-rotation scanning sparse data, a pre-amplification photoacoustic chord diagram and a post-amplification photoacoustic chord diagram; in step S2, an interpolation network is constructed and trained; a U-Net interpolation network is constructed, the pre-amplification photoacoustic chord diagram is taken as input, the post-amplification photoacoustic chord diagram is taken as a real label for training, error analysis training is performed, and an optimal interpolation model with minimum error is saved. The application replaces traditional multi-rotation angle physical rotation scanning by using deep learning virtual amplification sampling technology, significantly shortens imaging time, realizes high-speed three-dimensional imaging under single-pulse excitation, and is suitable for real-time dynamic monitoring scenes.