This invention relates to the field of
biomedical engineering technology and discloses a method and device for time-calibrated meridian detection based on multimodal sensing. The method includes the following steps: acquiring optical
volumetric imaging and
skin surface temperature signals of the subject, calculating the systematic
rhythm shift index, and determining the time-anchored acupoint nodes to generate a composite AC
constant current source
signal; initiating time-division isolation driving timing, sequentially injecting the
constant current source
signal individually into the target acupoint, time-anchored acupoint, and non-meridian reference node, while simultaneously acquiring differential
voltage signals; extracting the complex impedance modulus of each node through orthogonal
demodulation and calculating the
frequency domain polarizability; using the
polarizability of the non-meridian reference node and the time-anchored acupoint node as static and physiological upper limit benchmarks, respectively, performing differential and normalization operations to output a normalized meridian index. This invention eliminates
baseline drift caused by the endogenous diurnal
rhythm in the
human body, blocks electrical ground
crosstalk in multi-channel measurements, and improves the objectivity and
data stability of meridian
feature detection.