5828results about "Measurements using magnetic resonance" patented technology

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to above-mentioned tissue or organ, with an composition comprising antibody / fragment which specifically binds to targeted organ, tissue or cell. The antibody / fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.

The present invention provides systems and methods for the evaluation of the urethra and periurethral tissues using an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a decoupling circuit and a balun circuit. The interface circuit may also be in electrical communication with a MRI machine. In certain practices, the present invention provides methods for the diagnosis and treatment of conditions involving the urethra and periurethral tissues, including disorders of the female pelvic floor, conditions of the prostate and anomalies of the pediatric pelvis.

RF / MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W / kg and / or a whole body average SAR of at least about 2 W / kg. Related devices and methods of fabricating leads are also described.

A disposable tissue removal device comprises a “tube within a tube” cutting element mounted to a handpiece. The inner cannula of the cutting element defines an inner lumen and terminates in an inwardly beveled, razor-sharp cutting edge. The inner cannula is driven by both a pneumatic rotary motor and a pneumatic reciprocating motor. At the end of its stroke, the inner cannula makes contact with the cutting board to completely sever the tissue. An aspiration vacuum is applied to the inner lumen to aspirate excised tissue through the inner cannula and into a collection trap removably mounted to the handpiece. The rotary and reciprocating motors are hydraulically or pneumatically powered through a foot pedal operated pneumatically circuit. In one embodiment, the cutting element includes a cannula hub that can be connected to a fluid source, such as a valve-controlled saline bag.

An imaging system for use in medical intervention procedure planning includes a medical scanner system for generating a volume of cardiac image data, a data acquisition system for acquiring the volume of cardiac image data, an image generation system for generating a viewable image from the volume of cardiac image data, a database for storing information from the data acquisition and image generation systems, an operator interface system for managing the medical scanner system, the data acquisition system, the image generation system, and the database, and a post-processing system for analyzing the volume of cardiac image data, displaying the viewable image and being responsive to the operator interface system. The operator interface system includes instructions for using the volume of cardiac image data and the viewable image for bi-ventricular pacing planning, atrial fibrillation procedure planning, or atrial flutter procedure planning.

The invention relates to an MR imaging method for representing and determining the position of a medical device inserted in an examination object, and to a medical device used in the method. In accordance with the invention, the device (11) comprises at least one passive oscillating circuit with an inductor (2a, 2b) and a capacitor (3a, 3b). The resonance frequency of this circuit substantially corresponds to the resonance frequency of the injected high-frequency radiation from the MR system. In this way, in a locally limited area situated inside or around the device, a modified signal answer is generated which is represented with spatial resolution.

The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

This document discloses, among other things, multi-channel magnetic resonance using a TEM coil.

A catheter, including: a housing having a transverse inner dimension of at most about two millimeters; and a coil arrangement including five coils and five solid cores. Each of the coils is wound around one of the solid cores. The coils are non-coaxial. The coil arrangement is mounted inside the housing.

Using medical three-dimensional image data, at least one of a volume-rendering image, a flat reformatted image on an arbitrary section, a curved reformatted image, and an MIP (maximum value projection) image is prepared as a reference image. Vessel center lines are extracted from this reference image, and at least one of a vessel stretched image based on the center line and a perpendicular sectional image substantially perpendicular to the center line is prepared. The shape of vessels is analyzed on the basis of the prepared image, and the prepared stretched image and / or the perpendicular sectional image is compared with the reference image, and the result is displayed together with the images. Display of the reference image with the stretched image or the perpendicular sectional image is made conjunctive. Correction of the center line by the operator and automatic correction of the image resulting from the correction are also possible.

A neurostimulation system is configured for implantation into a patient's body and comprises a neurostimulator, a conductive stimulation lead having a first proximal end and a first distal end, at least one distal electrode electrically coupled proximate the first distal end, and a lead extension having a second proximal end electrically coupled to the neurostimulator and having a second distal end electrically coupled to the first proximal end. A shunt is electrically coupled to the first proximal end for diverting RF energy from the lead.

A configurable matrix receiver comprises a plurality of antennas that detect one or more signals. The antennas are coupled to a configurable matrix comprising a plurality of amplifiers, one or more switches that selectively couple the amplifiers in series fashion, and one or more analog-to-digital converters (ADCs) that convert the output signals generated by the amplifiers to digital form. For example, in one embodiment, a matrix comprises a first amplifier having a first input and a first output, and a second amplifier having a second input and a second output, a switch to couple the first output of the first amplifier to a the second input of the second amplifier, a first ADC coupled to the first output of the first amplifier, and a second ADC coupled to the second output of the second amplifier. In one embodiment, the signals detected by the antennas include magnetic resonance (MR) signals.

The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timing signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitized electrical signal. This method can be used with electrophysiological signals, such as EEG, ECG, EMG and galvanic skin response, and for elimination of noise associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.

Ultrasonic waveguides having improved velocity gain are disclosed for use in ultrasonic medical devices. Specifically, the ultrasonic waveguides comprises a first material having a higher acoustic impedance and a second material having a lower acoustic impedance.

A voltage compensation unit reduces the effects of induced voltages upon a device having a single wire line. The single wire line has balanced characteristic impedance. The voltage compensation unit includes a tunable compensation circuit connected to the wire line. The tunable compensation circuit applies supplemental impedance to the wire line. The supplemental impedance causes the characteristic impedance of the wire line to become unbalanced, thereby reducing the effects of induced voltages caused by changing magnetic fields.

Ultrasonic waveguides having improved velocity gain are disclosed for use in ultrasonic medical devices. Specifically, the ultrasonic waveguides comprises a first material having a higher acoustic impedance and a second material having a lower acoustic impedance.

A computer-implemented method and apparatus is provided for workflow configuration and execution in medical imaging. One method embodiment comprises the steps of creating and storing a workflow template (the workflow template comprising a standard form for entering data and activities), filling out the workflow template with data and a sequence of activities, and executing the sequence of activities according to the workflow template.

A system and method for assessing the quality of spot weld joints between pieces of metal includes an ultrasound transducer probing a spot weld joint. The ultrasound transducer transmits ultrasonic radiation into the spot weld joint, receives corresponding echoes, and transforms the echoes into electrical signals. An image reconstructor connected to the ultrasound transducer transforms the electrical signals into numerical data representing an ultrasound image. A neural network connected to the image reconstructor analyzes the numerical data and an output system presents information representing the quality of the spot weld joint. The system is trained to assess the quality of spot weld joints by scanning a spot weld joint with an ultrasound transducer to produce the data set representing the joint; then physically deconstructing the joint to assess the joint quality.

The present invention provides systems and methods for the evaluation of the urethra and periurethral tissues using an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a decoupling circuit and a balun circuit. The interface circuit may also be in electrical communication with a MRI machine. In certain practices, the present invention provides methods for the diagnosis and treatment of conditions involving the urethra and periurethral tissues, including disorders of the female pelvic floor, conditions of the prostate and anomalies of the pediatric pelvis.

A mechanically formed vortex transducer is described. The transducer has a plurality of piezoelectric elements suspended in an epoxy and heat molded into a desired shape. An irregularity in the transducer shape provides for a mechanically induced vortex focal field without the need for electronic steering or lens focusing. A system and methods of making the same are also described.

Critical needs for MRI patient instruction, testing, comfort, motion control, and speech communication are provided for better imaging which leads to more effective medical care. An MRI Digital Video Projection System is disclosed which provides better quality display to the patient to better inform, instruct, test, and comfort the patient plus the potential to stimulate the brain with microsecond onset times to better diagnose brain function. An MRI Motion Tracker and Patient Augmented Visual Feedback System enables monitoring patient body part motion, providing real time feedback to the patient and / or technician to substantially improve diagnostic yield of scanning sessions, particularly for children and mentally challenged individuals. An MR Forward Predictive Noise Canceling Microphone System removes the intense MRI acoustic noise improving patient communication, patient safety and enabling coding of speech output. These systems can be used individually but maximum benefit is from providing all three.

Provided is a highly accurate optical pumping magnetometer, in which a static magnetic field and an oscillating field to be applied to a vapor cell are stabilized. To this end, the optical pumping magnetometer includes: Helmholtz coils for applying a constant static magnetic field to a vapor cell serving as a magnetic field detector; fluxgate magnetometers for detecting environmental magnetic noise in two directions of X-axis direction and Y-axis direction other than Z-axis direction which is a direction for detecting a magnetic field coming out of a measurement object while locating the vapor cell in the center thereof; magnetometer drive circuits for driving the fluxgate magneotometers; current converters for converting outputs of the magnetometer drive circuits into amount of currents; and magnetic field generating coils for generating a magnetic field in a phase opposite to the environmental magnetic noise in the two directions.

A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and / or RING electrode for an active implantable medical device.

A voltage compensation unit reduces the effects of induced voltages upon a device having a single wire line. The single wire line has balanced characteristic impedance. The voltage compensation unit includes a tunable compensation circuit connected to the wire line. The tunable compensation circuit applies supplemental impedance to the wire line. The supplemental impedance causes the characteristic impedance of the wire line to become unbalanced, thereby reducing the effects of induced voltages caused by changing magnetic fields.

An atomic magnetometer is disclosed which uses a pump light beam at a D1 or D2 transition of an alkali metal vapor to magnetically polarize the vapor in a heated cell, and a probe light beam at a different D2 or D1 transition to sense the magnetic field via a polarization rotation of the probe light beam. The pump and probe light beams are both directed along substantially the same optical path through an optical waveplate and through the heated cell to an optical filter which blocks the pump light beam while transmitting the probe light beam to one or more photodetectors which generate electrical signals to sense the magnetic field. The optical waveplate functions as a quarter waveplate to circularly polarize the pump light beam, and as a half waveplate to maintain the probe light beam linearly polarized.