15results about How to "Increased toxicity" patented technology

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The application discloses a kind of low-carbon cementing material by waste incineration fly ash excited ore powder and preparation method thereof, by weight percentage, including the following components: modified waste incineration fly ash 8~12%, ion complex component 1~3%, composite shrinkage component 2~6%, ore powder 55~65%, water 23~28%.Preparation method includes the following steps: S1, preparation modified waste incineration fly ash, ion complex component, composite shrinkage component;S2, modified waste incineration fly ash, ion complex component, composite shrinkage component, ore powder, mixing water, fully mixed and stirred evenly, can obtain the low-carbon cementing material by waste incineration fly ash excited ore powder described in the application.In the aspect of component design, the application is environmentally friendly, low cost, in the performance aspect, the flow rate can be adjusted, the mechanical properties are excellent, the volume shrinkage is small.

A compound of formula (I), or a tautomer, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound represented by formula (I) or the tautomer, the stereoisomer or the pharmaceutically acceptable salt thereof, as a novel linker compound, can be used for preparing an ADC medicament with a high DAR value. The present invention also relates to an ADC medicament prepared from the linker.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention discloses an efficient synthesis method of 2-acetamido-pyridine-3-formic acid, which comprises the following steps: taking 2-amino-3-methylpyridine as a raw material, firstly reacting with acetic anhydride in a micro-channel reactor, and carrying out post-treatment to obtain 2-acetamido-3-methylpyridine; and then, carrying out catalytic oxidation on the intermediate in a water-ethanol system in an oxygen environment by taking iridium trichloride, copper 2-picolinate, N-hydroxyphthalimide and iodobenzene as a catalytic system. And filtering out and recovering the catalyst after the reaction, and carrying out two-step programmed cooling crystallization and activated carbon decoloration refining on mother liquor to obtain a high-purity target product. The method has the advantages of cheap raw materials, adoption of a green solvent and oxygen as oxidants, mild reaction conditions, high product yield and purity, few three wastes, recoverable catalyst, and facilitation of industrial production.

The application discloses a kind of hydrorefining catalyst activation methods of hydrocarbon oil.The method includes the process of reduction to hydrorefining catalyst of hydrocarbon oil, wherein, the hydrorefining catalyst includes alumina carrier, metal molybdenum, organic nickel and organic metal auxiliary agent, the metal auxiliary agent is at least one or several of zinc, copper, magnesium, gallium, with the weight of final hydrogenation catalyst as basis, the mass content of organic nickel is 0.1% to 4.0%, preferably 0.2% to 3.0%, further preferably 0.5% to 2.0%, with the metal auxiliary agent element as basis, the mass content of organic metal auxiliary agent is 0.05% to 2.5%, preferably 0.1% to 2.0%, further preferably 0.2% to 1.5%.The method has the advantages of time-saving and high efficiency, without adding sulfidation agent, and more simple and convenient to switch raw materials.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

The invention discloses a traditional Chinese medicine compound cell culture fluid and application thereof. The traditional Chinese medicine compound cell culture fluid comprises a basic culture medium, and 1 L of the basic culture medium contains 2-10 mg of notoginsenoside R1, 1-5 mg of notoginsenoside Rb1, 1-5 mg of notoginsenoside Rg1, 0.1-1 mg of notoginsenoside Rg3, 0.5-2 mg of notoginsenoside Re, 1-6 [mu] g of shikonin, 5-15 [mu] g of cordycepin and 1-20 mg of basil polysaccharide. In the traditional Chinese medicine compound cell culture fluid, notoginsenoside Rg3 can be combined with shikonin, so that the cytotoxicity can be enhanced, cord blood NK cells are promoted to be differentiated to mature functional phenotypes with high cytotoxic activity, and the killing efficiency of the NK cells on various tumor target cells is remarkably improved; the notoginsenoside Rb1 is combined with the basil polysaccharide, so that the NK cells can be driven to expand and grow, the activity of the NK cells can be maintained, and the cell purity can be improved, so that the persistence of the cell activity can be enhanced, and the tumor killing rate of the NK cells can be improved.

The invention discloses an OX-Dex NPs preparation based on pH and spermine double cascade response, a preparation method and application, and belongs to the technical field of medicine preparation. The preparation method comprises the following steps: firstly, activating glucan by using excessive N, N '-carbonyldiimidazole, and then reacting with ethylenediamine to synthesize an amino-modified glucan intermediate; the preparation method comprises the following steps: firstly, preparing an amino-modified dextran intermediate, then connecting L-phenylalanine to the amino-modified dextran intermediate through a coupling reaction, and then self-assembling with oxaliplatin in the presence of cucurbit [8] uril and glutaraldehyde, so that the formed OX-Dex NPs preparation shows excellent cascade response characteristic to pH and spermine. Meanwhile, the OX (at) Dex NPs shows extremely low toxicity to human normal hepatocytes (LO-2) with low spermine expression and has remarkable toxicity to mouse breast cancer cells (4T1) with high spermine expression, and an efficient and safe technical scheme is provided for selection of breast cancer chemotherapy drugs.

The invention provides application of a persimmon leaf flavonoid compound in preparation of a drug for enhancing cis-platinum sensitivity, and belongs to the technical field of biological medicine. The invention provides a nanoparticle formed by self-assembly of a persimmon leaf flavonoid compound and a platinum drug. In-vivo and in-vitro experiment results show that when the persimmon leaf flavonoid compound and the cis-platinum are combined for administration, the killing ability of the cis-platinum to tumor cells can be improved, and when the persimmon leaf flavonoid compound and the cis-platinum are prepared into the nanoparticles (PLF-Cis NPs), the toxicity, the anti-proliferation property and the anti-migration property of the cis-platinum to cancer cells can be greatly further improved. The PLF-Cis NPs can improve the killing effect, promote cell apoptosis and induce cell immunogenic death. According to the invention, the persimmon leaf flavonoid compound is used as the sensitizer for the first time, so that the tumor killing property of platinum drugs can be greatly improved, and a new means is provided for treating tumors or cancers with poor cis-platinum sensitivity.

This invention discloses a double-layer composite ceramic fiber filter tube with functions of flue gas dust removal, nitrous oxide removal, and dioxin removal, and its preparation method. The ceramic fiber tube consists of an outer filter layer and an inner catalyst layer. The ceramic fiber tube provided by this invention has high dust removal efficiency at 150℃~400℃, high nitrous oxide removal efficiency, and high dioxin removal efficiency. The preparation process is simple and has few steps. The active components are uniformly dispersed on the carrier, with adjustable loading and high bonding strength. This material can achieve integrated treatment of dust, nitrous oxide, and dioxins, efficiently simplifying the treatment process of industrial exhaust gas purification and reducing flue gas treatment costs.

This invention provides a reactive oxygen species (ROS)-activated nitrogen mustard prodrug, its preparation method, and its application. This invention belongs to the field of medicinal chemistry. By introducing ROS-sensitive groups into nitrogen mustard compounds, it maintains an inactive state in normal tissues, only becoming activated in the tumor microenvironment due to elevated ROS levels, releasing cytotoxic nitrogen mustard components. This ROS-activated nitrogen mustard prodrug not only overcomes the shortcomings of traditional nitrogen mustard drugs but also provides new directions and ideas for the development of antitumor drugs. Furthermore, this nitrogen mustard prodrug enriches the structural types of nitrogen mustard prodrugs, improves drug selectivity in tumor cells, and reduces toxic side effects.

The application discloses a drum stirring type low-temperature plasma activated carbon particle regeneration device, which comprises a stirring tank, an input unit, a stirring unit and a low-temperature plasma degradation unit.The axis of the stirring tank is horizontally arranged, and an input port and an output port are arranged at two ends of the stirring tank respectively.The output end of the input unit is communicated with the input port of the stirring tank, and the input unit is used for inputting waste activated carbon into the stirring tank.The stirring unit is arranged in the stirring tank.The low-temperature plasma degradation unit is arranged at the central position of the stirring unit, and the discharge electrode is in a cylindrical structure.The gas inlet of the waste gas treatment unit is communicated with the output port of the stirring tank.The waste activated carbon regeneration process is combined with the low-temperature plasma, the organic pollutants in the waste gas generated in the waste activated carbon regeneration process are synchronously degraded, the energy utilization rate is high, the secondary pollution is small, and the subsequent waste gas treatment difficulty is low.

The application discloses a kind of water quality comprehensive toxicity high flux determination method, the determination method includes using sewage sample to expose the test organism after being contaminated, obtains the phenotypic characteristic data of test organism;Toxicity matrix is constructed;Establish machine learning model, determine the water quality comprehensive toxicity of sewage sample in combination with toxicity matrix.The water quality comprehensive toxicity determination method provided by the application does not need sample concentration enrichment, guarantees the comprehensiveness and accuracy of detection result, and can be applied to the comprehensive toxicity high flux determination of sewage treatment plant whole-process sewage.

This invention discloses a catalyst for the synergistic removal of multiple pollutants from waste incineration flue gas, its preparation method, and its application, relating to the field of industrial waste gas purification and environmental catalytic materials technology. The catalyst uses a titanium-based composite support as the carrier, vanadium-tungsten-titanium as the active matrix, and is loaded with composite modifying components. The mass fraction of each component in the entire catalyst is as follows: vanadium component (V2O5) 1.0%~5.0%, tungsten component (WO3) 3.0%~10.0%, composite modifying component 0.5%~8.0%, and titanium-based composite support 77%~95.5%. The titanium-based composite support is a TiO2-MOFs-derived carbon composite support or a titanium-based two-dimensional layered composite support. The composite modifying component is a mixture of conventional metal oxides and novel synergistic components. The conventional metal oxides are selected from CeO2 and MnO2, and the novel synergistic components are selected from one or two of Nb2O5, MoO3, and WS2. This catalyst can achieve NO removal within a synergistic temperature window of 200~350℃. x Hg 0 The removal efficiency of pollutants such as dioxins is no less than 80%, and the removal efficiency decreases by no more than 5% after 1000 hours of continuous operation.