37results about How to "Increased toxicity" patented technology

The invention discloses a water quality comprehensive toxicity high-throughput determination method, which comprises the following steps: performing exposure contamination on a tested organism by using a sewage sample to obtain phenotypic characteristic data of the tested organism; constructing a toxicity matrix; establishing a machine learning model, and determining the water quality comprehensive toxicity of the sewage sample in combination with the toxicity matrix. The water quality comprehensive toxicity determination method provided by the invention does not need sample concentration and enrichment, ensures the comprehensiveness and accuracy of the detection result, and can be applied to the comprehensive toxicity high-flux determination of the sewage in the whole process of a sewage treatment plant.

A hyaluronic acid derivative pharmaceutical composition comprising (A) a hyaluronic acid derivative into which a hydrophobic group is introduced, (B) an association promoter, and (C) an active ingredient. Preferably, the association accelerator (B) contains at least four ether structures (R-O-R), and satisfies the condition that the number of carbon atoms is 4 or more.

The invention relates to an HER2 (human epidermal growth factor receptor 2) targeting antibody coupling gold (III) porphyrin medicine as well as a synthesis method and tumor treatment application thereof. The antibody coupling gold (III) porphyrin drug targeting HER2 is formed by connecting an anti-HER-2 trastuzumab and an A3B type gold (III) porphyrin complex through a linker, and the linker comprises a maleimide joint connected with an antibody and a self-elimination joint connected with the A3B type gold (III) porphyrin complex. The A3B type gold (III) porphyrin complex with anti-tumor activity is combined with trastuzumab with a specific recognition function as a carrier, the antibody is utilized to accurately strike tumor cells, a medicine is delivered to a tumor environment, the tumor targeting property of the gold (III) porphyrin complex is improved, and accurate treatment is realized. Distribution of drugs in the body can be improved, accumulation of the drugs in non-tumor sites can be reduced, the dosage of metal complexes is reduced, and toxic and side effects are reduced; the efficient delivery of gold drugs to tumor tissues can also be realized, and the cancer treatment effect is improved.

The invention discloses an environmentally friendly aluminum paint stripper and a preparation method thereof in the field of paint stripper technology, including the following components by weight: 15-20 parts of alkaline substances, 8-10 parts of catalyst promoters, 6-8 parts of cosolvents, 3-5 parts of de-agent promoters, 3.6-4.6 parts of surfactants and 200-230 parts of deionized water. The present invention proposes to prepare a water-based environmentally friendly alkaline paint stripper by selecting a high-boiling-point low-toxicity component, thereby achieving the technical effect of paint stripper environmental protection, and preparing a catalyst promoter at the same time, connecting a carbon shell with nano-iron tetroxide as the core, loading an alkaline metal oxide, and improving the degradation rate of the paint film, thereby reducing the paint stripping time and reducing the substrate loss.

The invention provides a gold-copper nanocluster with efficient multi-source active oxygen generation performance and a preparation method and application of the gold-copper nanocluster, and belongs to the field of biomedical materials. The gold-copper nanocluster is synthesized through mediation of Tf, and Tf is full transferrin, iron-saturated transferrin or siderophore. The gold-copper nanocluster with Tf as the ligand is synthesized by adopting a simple one-pot method, and the problems that in the prior art, a multi-source active oxygen generation system is complex to construct and a preparation method is tedious are solved; the gold-copper nanocluster synthesized by taking Tf as a ligand can be used as a simple multi-source active oxygen generation system, superoxide anions can be generated through photosensitized oxidation activity sensitization oxygen, and hydroxyl radicals can be generated through peroxidase-like activity catalysis hydrogen peroxide, so that efficient generation of multi-source active oxygen is realized; and the effect of enhancing tumor treatment is achieved.

The invention belongs to the technical field of medical preparations, and particularly relates to a resveratrol-succinyl glycan-tetravalent platinum nano-drug as well as a preparation method and application of the resveratrol-succinyl glycan-tetravalent platinum nano-drug. In the resveratrol-succinyl glycan-tetravalent platinum nano-drug provided by the invention, the succinyl glycan (RIC) can exert the anti-tumor activity by improving the immune function of a body; resveratrol (RES) can be used for directly acting on related targets and the like to exert anti-tumor activity by inhibiting proliferation of tumor cells, inducing apoptosis of the tumor cells, inhibiting invasion and metastasis of the tumor cells and regulating the immune function of a body. According to the invention, the succinylglycan-tetravalent platinum conjugate is used for wrapping an anti-cancer drug micromolecule RES, so that the anti-cancer curative effect of the drug is improved, the problems of toxic and side effects of platinum drugs, drug resistance of tumor cells and the like are solved, and a new idea is provided for construction and application of platinum nano-drugs.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The application discloses a kind of low-carbon cementing material by waste incineration fly ash excited ore powder and preparation method thereof, by weight percentage, including the following components: modified waste incineration fly ash 8~12%, ion complex component 1~3%, composite shrinkage component 2~6%, ore powder 55~65%, water 23~28%.Preparation method includes the following steps: S1, preparation modified waste incineration fly ash, ion complex component, composite shrinkage component;S2, modified waste incineration fly ash, ion complex component, composite shrinkage component, ore powder, mixing water, fully mixed and stirred evenly, can obtain the low-carbon cementing material by waste incineration fly ash excited ore powder described in the application.In the aspect of component design, the application is environmentally friendly, low cost, in the performance aspect, the flow rate can be adjusted, the mechanical properties are excellent, the volume shrinkage is small.

A compound of formula (I), or a tautomer, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound represented by formula (I) or the tautomer, the stereoisomer or the pharmaceutically acceptable salt thereof, as a novel linker compound, can be used for preparing an ADC medicament with a high DAR value. The present invention also relates to an ADC medicament prepared from the linker.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention relates to the field of synthesis of pyrazolone, and provides a method for synthesizing a pyrazolone structure by utilizing carbon dioxide aiming at the problem that an expensive transition metal catalyst and high-toxicity carbon monoxide are needed for synthesizing pyrazolone by utilizing carbonylation reaction, and the reaction formula is as follows: # imgabs0 # reaction conditions are as follows: in the presence of carbon dioxide, in an organic solvent and under the action of alkali, the reaction is carried out for 1-3 hours, so that the pyrazolone structure is synthesized by utilizing carbon dioxide. And reacting the compound II with carbon dioxide to obtain the pyrazolone structure. According to the method, the pyrazolone structure is synthesized in a green and efficient manner by utilizing carbon dioxide.

The invention aims to provide a preparation method of a rubber hot water pipe. The preparation method comprises the following specific steps: 1) preparing a rubber composition containing rubber; 2) manufacturing a resin mixture composed of resin; (3) a resin mixture is mixed into the rubber composition, a rubber composition mixture is manufactured, and the weight ratio of the rubber composition to the resin mixture is 100: (10-30); and 4) melting the rubber composition mixture under the temperature condition of 210-250 DEG C, and molding to manufacture a pipeline molded product. According to the method, the pressure resistance, the heat resistance, the antibacterial property, the wear resistance, the impact resistance and other characteristics of the hot water pipe can be enhanced, the resistance to external impact is improved, and meanwhile the antibacterial property and the deodorization property of the hot water pipe are improved. Besides, the hot water pipe is made of elastic rubber materials, construction is easy, the vortex phenomenon generated in a bent or bent pipeline along with flowing of fluid can be reduced, and it is guaranteed that the fluid can be smoothly supplied.

The invention discloses an efficient synthesis method of 2-acetamido-pyridine-3-formic acid, which comprises the following steps: taking 2-amino-3-methylpyridine as a raw material, firstly reacting with acetic anhydride in a micro-channel reactor, and carrying out post-treatment to obtain 2-acetamido-3-methylpyridine; and then, carrying out catalytic oxidation on the intermediate in a water-ethanol system in an oxygen environment by taking iridium trichloride, copper 2-picolinate, N-hydroxyphthalimide and iodobenzene as a catalytic system. And filtering out and recovering the catalyst after the reaction, and carrying out two-step programmed cooling crystallization and activated carbon decoloration refining on mother liquor to obtain a high-purity target product. The method has the advantages of cheap raw materials, adoption of a green solvent and oxygen as oxidants, mild reaction conditions, high product yield and purity, few three wastes, recoverable catalyst, and facilitation of industrial production.

The application discloses a kind of hydrorefining catalyst activation methods of hydrocarbon oil.The method includes the process of reduction to hydrorefining catalyst of hydrocarbon oil, wherein, the hydrorefining catalyst includes alumina carrier, metal molybdenum, organic nickel and organic metal auxiliary agent, the metal auxiliary agent is at least one or several of zinc, copper, magnesium, gallium, with the weight of final hydrogenation catalyst as basis, the mass content of organic nickel is 0.1% to 4.0%, preferably 0.2% to 3.0%, further preferably 0.5% to 2.0%, with the metal auxiliary agent element as basis, the mass content of organic metal auxiliary agent is 0.05% to 2.5%, preferably 0.1% to 2.0%, further preferably 0.2% to 1.5%.The method has the advantages of time-saving and high efficiency, without adding sulfidation agent, and more simple and convenient to switch raw materials.

The invention discloses a cross-linked netted water-soluble polymer paper reinforcing agent and a preparation method thereof, and belongs to the field of paper reinforcing, at 60-120 DEG C, a catalyst and an amino-containing cross-linking agent are added into a mixed solution dissolved with polyvinyl alcohol and sodium carboxymethyl cellulose while stirring, the catalyst is zinc chloride or aluminum chloride, and then heat preservation treatment is performed; and cooling the obtained reaction system, adding a silane coupling agent, then preserving heat for 0.5-2 hours, and adjusting the pH value of the obtained reaction system to be neutral to obtain the cross-linked network water-soluble polymer paper reinforcing agent, which has wide application prospects in the production of various types of paper (such as packaging paper, writing paper, printing paper and the like).

The invention belongs to the technical field of biological medicine, and relates to a BODIPY-based photosensitizer compounded platinum complex, a preparation method and application thereof, the BODIPY-based photosensitizer compounded platinum complex comprises a cis-platinum complex c-BBP or a counter-platinum complex t-BBP, the molecular formula of the cis-platinum complex c-BBP and the counter-platinum complex t-BBP is C36H42B2F4N8Pt, the molecular formula of the counter-platinum complex c-BBP is C36H42B2F4N8Pt, and the molecular formula of the counter-platinum complex t-BBP is C36H42B2F4N8Pt. The platinum complex is combined with a BODIPY photosensitizer and combined with PDT, the defects of platinum drugs are effectively overcome, the complex has an inhibiting effect on tumor cells, and a new direction is provided for development of new anti-cancer drugs.

The present invention relates to the technical field of catalysts, and discloses a close-coupled SCR catalyst and a preparation method and application thereof, wherein the catalyst comprises a molecular sieve and indium oxide; the indium oxide is loaded on the surface of the molecular sieve in the form of particles; the indium oxide is A x In 1‑x O y , wherein A is one or more selected from Ce, La, Pr, Nb, Ga, Ni, Gd, Zn, Cr, Sr, and Zr; In is indium; O is oxygen; 0≤x<1, and y is determined by the chemical formula balancing method of indium oxide. The catalyst obtained by the present invention not only effectively improves the catalyst's resistance to hydrocarbon poisoning, solves the problem of catalyst deactivation due to hydrocarbon poisoning in the ccSCR system, but also improves the catalyst's low-temperature activity, broadens the active temperature window and N 2 Selective.

The invention discloses a traditional Chinese medicine composition capable of relieving diarrhea caused by cryptosporidium parvum as well as a preparation method and application of the traditional Chinese medicine composition, and belongs to the technical field of medicines. The traditional Chinese medicine composition consists of a prescription for clearing intestines and resolving dampness and allicin, the prescription for clearing intestines and resolving dampness is composed of scutellaria baicalensis, coptis chinensis, roasted radix aucklandiae, fried angelica sinensis, sanguisorba officinalis, parched white peony root, angelica dahurica and liquorice. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of radix scutellariae, 6-10 parts of rhizoma coptidis, 6-10 parts of roasted radix aucklandiae, 10-15 parts of fried radix angelicae sinensis, 10-15 parts of radix sanguisorbae, 15-20 parts of fried radix paeoniae alba, 10-20 parts of radix angelicae, 6-10 parts of liquorice root and 0.02-0.07 part of allicin. The traditional Chinese medicine composition prepared by the invention is efficient, low in toxicity, safe and harmless, and can relieve diarrhea caused by cryptosporidium parvum, relieve intestinal injury, regulate the composition structure of intestinal flora and enhance intestinal barrier and immunity.

The invention relates to the technical field of MEMS sensors, and discloses an MEMS catalytic methane sensor capable of resisting sulfide poisoning and a preparation method of the MEMS catalytic methane sensor. The preparation method comprises the following steps: S1, carrying out a synthetic reaction on a main body material and a modified material to obtain a carrier material primary product; washing and drying the primary product of the carrier material, and carrying out heat treatment to finally obtain the carrier material; s2, dissolving a catalyst A and a catalyst B in pure water, performing stirring treatment, then adding the carrier material prepared in the step S1, performing ultrasonic oscillation dispersion under a room temperature condition, firstly transferring obtained powder into a muffle furnace, performing heat treatment, and then transferring the powder into a tubular furnace to prepare modified carrier powder; s3, preparing black element slurry, white element slurry and catalyst slurry; and S4, preparing the MEMS catalytic methane element. The sulfide poisoning resistant MEMS catalytic methane sensor prepared by the invention is suitable for a plurality of fields of coal mines, industry, civil use and the like, has wide applicability, and can better improve the low-temperature combustion and sulfide poisoning resistance of methane.

The invention discloses a semi-prefabricated plastic runway foaming coil, and relates to the technical field of plastic runways. The present application adopts a hindered amine 4-amino-2,2,6,6-tetramethylpiperidine to react with the aldehyde group of p-hydroxybenzaldehyde to generate a Schiff base containing a piperidine ring, and grafts with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, and then a hindered phenol 3,5-bis(tert-butyl)-4-hydroxyphenylpropionyl chloride is reacted with the hydroxyl group of p-hydroxybenzaldehyde to generate a flame retardant containing both hindered phenol and hindered amine, and the flame retardant is added to polyurethane to improve the flame retardant performance of the plastic runway on the one hand, and the anti-aging performance of the plastic runway is also improved on the other hand.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

The present invention provides a method for preparing ultra-thin flexible glass by using biomimetic weathering enzyme compound glass thinning agent, by learning and imitating the principle that plants secrete biomimetic weathering enzyme secreted to corrode rocks in nature, manually extracting and synthesizing biomimetic weathering enzyme, and uniformly dissolving glass by using the biomimetic weathering enzyme, and taking out and cleaning to obtain the thinned glass when a remaining thickness is left. The biomimetic weathering enzyme compound glass thinning agent of the present invention is based on biomimetic weathering enzyme, which has low toxicity and is safer in use; and it can evenly and continuously dissolve the glass without causing surface roughness, and can evenly and continuously thin the glass. As long as a thinning time is controlled, ultra-thin glasses with a series of thicknesses may be obtained with high yield and simple subsequent cleaning. The obtained ultra-thin flexible glass with a thickness of 20 microns can achieve a minimum bending radius of only 0.35 mm, and has a surface roughness Ra of less than 10 nm, , a visible light transmittance under the pure glass condition is higher than 90%, and the hardness thereof is the same as that of a raw glass.

A cell lysis buffer separation apparatus for preparing a polypeptide, and a system and the application thereof. The system comprises a polypeptide enrichment module, wherein the polypeptide enrichment module comprises a cell lysis buffer separation apparatus, and the cell lysis buffer separation apparatus comprises a multi-filtration device and a waste discharge pipeline, the waste discharge pipeline being connected to the multi-filtration device. The system can perform multi-filtration treatment on a lysis buffer. Therefore, the yield of target protein can be increased; and a waste liquid obtained by means of the system contains almost no toxin polypeptide precursor with low toxicity, and has very little toxicity to an operating environment, and same can be directly discharged after simple disinfection treatment, thereby greatly reducing production cost and promoting large-scale industrial production of polypeptide under the conditions of ensuring the safety of the environment and the safety of operators.

The invention discloses a traditional Chinese medicine compound cell culture fluid and application thereof. The traditional Chinese medicine compound cell culture fluid comprises a basic culture medium, and 1 L of the basic culture medium contains 2-10 mg of notoginsenoside R1, 1-5 mg of notoginsenoside Rb1, 1-5 mg of notoginsenoside Rg1, 0.1-1 mg of notoginsenoside Rg3, 0.5-2 mg of notoginsenoside Re, 1-6 [mu] g of shikonin, 5-15 [mu] g of cordycepin and 1-20 mg of basil polysaccharide. In the traditional Chinese medicine compound cell culture fluid, notoginsenoside Rg3 can be combined with shikonin, so that the cytotoxicity can be enhanced, cord blood NK cells are promoted to be differentiated to mature functional phenotypes with high cytotoxic activity, and the killing efficiency of the NK cells on various tumor target cells is remarkably improved; the notoginsenoside Rb1 is combined with the basil polysaccharide, so that the NK cells can be driven to expand and grow, the activity of the NK cells can be maintained, and the cell purity can be improved, so that the persistence of the cell activity can be enhanced, and the tumor killing rate of the NK cells can be improved.

The invention discloses an OX-Dex NPs preparation based on pH and spermine double cascade response, a preparation method and application, and belongs to the technical field of medicine preparation. The preparation method comprises the following steps: firstly, activating glucan by using excessive N, N '-carbonyldiimidazole, and then reacting with ethylenediamine to synthesize an amino-modified glucan intermediate; the preparation method comprises the following steps: firstly, preparing an amino-modified dextran intermediate, then connecting L-phenylalanine to the amino-modified dextran intermediate through a coupling reaction, and then self-assembling with oxaliplatin in the presence of cucurbit [8] uril and glutaraldehyde, so that the formed OX-Dex NPs preparation shows excellent cascade response characteristic to pH and spermine. Meanwhile, the OX (at) Dex NPs shows extremely low toxicity to human normal hepatocytes (LO-2) with low spermine expression and has remarkable toxicity to mouse breast cancer cells (4T1) with high spermine expression, and an efficient and safe technical scheme is provided for selection of breast cancer chemotherapy drugs.

The present invention discloses a method for treating organic phosphine wastewater by using homogeneous catalytic wet oxidation, which includes a wet oxidation section, a biochemical treatment section and a phosphorus recovery section; the organic phosphine wastewater, the homogeneous catalyst and the mother liquor of the single membrane electrodialysis are mixed and heated by heat exchange, and then the wet oxidation treatment is carried out, and then the acid adjustment tank is entered after cooling, and then nanofiltration is carried out, the nanofiltration concentrated water enters the single membrane electrodialysis treatment, the single membrane electrodialysis mother liquor is returned to the regulating tank, the anion liquid enters the phosphorus recovery section, and the nanofiltration produced water enters the biochemical treatment section; the biochemical treatment section includes an alkali adjustment tank, a biochemical unit and an effluent monitoring tank in sequence, and the phosphorus recovery section includes a reaction tank and a concentration crystallization unit, and finally forms a product struvite. In view of the characteristics of high COD, high organic phosphorus, high toxicity and difficult degradation of organic phosphine wastewater, the present invention adopts a treatment process with homogeneous catalytic wet oxidation as the core, giving full play to the characteristics of high catalytic activity and strong treatment capacity of homogeneous catalytic wet oxidation, and finally achieving the standard discharge of organic phosphine wastewater.

The invention discloses an application of a metallothionein gene knockout sgRNA in preparation of a drug for treating tumor disulfiram, a molecular mechanism influencing DSF drug resistance is found through RNA sequencing and data analysis, and a sequencing result shows that multiple enriched genes of up-regulated genes of a DSF treatment group belong to a metallothionein gene MTs family; real-time PCR detection finds that mRNA expression of tumor cells MTs treated by DSF is increased, and the result is consistent with a sequencing result; in order to determine whether up-regulation of MTs expression is related to tumor cell DSF drug resistance, expression of MT1X and MT2A in an MTs gene family is down-regulated by using a gene knockout technology, and sensitivity of a tumor cell line in which MT1X and MT2A are knocked out to DSF is increased, so that MTs can be used as a target spot of DSF anti-tumor treatment.

The invention provides application of a persimmon leaf flavonoid compound in preparation of a drug for enhancing cis-platinum sensitivity, and belongs to the technical field of biological medicine. The invention provides a nanoparticle formed by self-assembly of a persimmon leaf flavonoid compound and a platinum drug. In-vivo and in-vitro experiment results show that when the persimmon leaf flavonoid compound and the cis-platinum are combined for administration, the killing ability of the cis-platinum to tumor cells can be improved, and when the persimmon leaf flavonoid compound and the cis-platinum are prepared into the nanoparticles (PLF-Cis NPs), the toxicity, the anti-proliferation property and the anti-migration property of the cis-platinum to cancer cells can be greatly further improved. The PLF-Cis NPs can improve the killing effect, promote cell apoptosis and induce cell immunogenic death. According to the invention, the persimmon leaf flavonoid compound is used as the sensitizer for the first time, so that the tumor killing property of platinum drugs can be greatly improved, and a new means is provided for treating tumors or cancers with poor cis-platinum sensitivity.

The invention discloses a chimeric antigen receptor for expressing a membrane-anchored PD-1 antibody and application, and relates to the technical field of biological medicines. An MSLN antigen is used as a target spot, an immune checkpoint PD-1 is combined for design, an optimal mode for combining the MSLN antigen and the immune checkpoint PD-1 is found, an MSLN CAR molecule for expressing a membrane anchoring PD-1 antibody is obtained, and a novel CAR-T cell therapy is developed based on the CAR molecule. Specifically, the invention provides a chimeric antigen receptor containing an MSLN targeting structure and a PD-1 antibody anchoring structure, the MSLN targeting structure comprises a coding sequence of the chimeric antigen receptor targeting MSLN, and the PD-1 antibody anchoring structure comprises a coding sequence of a membrane anchored PD-1 antibody. In-vitro and in-vivo experiments show that the treatment effect of the anti PD-1 amplified MSLN CAR-T is superior to that of a second generation MSLN CAR-T and that of a fourth generation MSLN CAR-T secreting a PD-1 antibody, the molecule can enable MSLN and PD-1 to have a synergistic effect, the immune effect of the CAR molecule is greatly improved, and the life cycle of tumor patients is obviously prolonged.

This invention discloses a double-layer composite ceramic fiber filter tube with functions of flue gas dust removal, nitrous oxide removal, and dioxin removal, and its preparation method. The ceramic fiber tube consists of an outer filter layer and an inner catalyst layer. The ceramic fiber tube provided by this invention has high dust removal efficiency at 150℃~400℃, high nitrous oxide removal efficiency, and high dioxin removal efficiency. The preparation process is simple and has few steps. The active components are uniformly dispersed on the carrier, with adjustable loading and high bonding strength. This material can achieve integrated treatment of dust, nitrous oxide, and dioxins, efficiently simplifying the treatment process of industrial exhaust gas purification and reducing flue gas treatment costs.