63results about How to "Increased toxicity" patented technology

The invention discloses a carbon dioxide adsorbent and a preparation method and application thereof.The preparation method comprises the following steps that a biological shell material is cleaned and then dried, the pretreated biological shell material is ground, and coarse shell powder is obtained; sequentially calcining and grinding the coarse shell powder in a protective atmosphere to obtain shell micro powder; mixing the shell micro powder with a magnesium oxide solid phase, calcining in a protective atmosphere, and grinding to obtain the carbon dioxide adsorbent. According to the invention, a solid-phase mixing method is adopted, and the marine biological waste with specific content and magnesium oxide are mixed, so that the mutual cooperation and mutual synergism among the raw material components can be fully exerted, the element composition and microstructure of the adsorbent material can be effectively regulated and controlled, and by virtue of the preparation method which is easy to operate and low in cost, the adsorbent material can be prepared. The obtained novel carbon dioxide adsorbent can improve the CO2 adsorption capacity and cycle stability of MgO, and can stably maintain high carbon dioxide adsorption rate and adsorption capacity for a long time.

The invention discloses a preparation method of an amphiphilic carbon dot, the amphiphilic carbon dot and application of the amphiphilic carbon dot. According to the amphiphilic carbon dots, at least one of phenol, catechol, resorcinol or hydroquinone is used as a first precursor, and at least one of urea, aniline, o-phenylenediamine or 1, 2, 4-triaminobenzene is selected as a second precursor; after mixing and dissolving, reacting for 4-8 hours under the condition of 180-220 DEG C to prepare initial carbon dots; separating and purifying the initial carbon dots in a chromatographic column, collecting a second component, removing the solvent through rotary evaporation, and drying to obtain the amphiphilic carbon dots. The degreasing agent prepared from the obtained amphiphilic carbon dots has strong adsorption capacity, low toxicity and good stability, can effectively remove oil stains, has the characteristic of low foam in the use process, simplifies the cleaning process and improves the efficiency.

The invention relates to a culture medium and a culture method of persistent DC-CIK cells and application of the culture medium and the culture method, and belongs to the technical field of cell culture. The invention provides a culture medium for persistent DC-CIK cells, which takes a serum-free culture medium as a solvent and comprises a recombinant human granulocyte macrophage colony stimulating factor, a recombinant human interleukin-12, a recombinant human tumor necrosis factor-alpha, a recombinant human interferon-gamma, L-cysteine, glutathione, ginseng polysaccharide and streptomycin sulfate. According to the culture medium and the culture method of the persistent DC-CIK cells, proliferation and growth of the DC-CIK cells can be promoted, and very high tumor killing activity of the DC-CIK cells can be maintained for a long time.

The invention discloses a water quality comprehensive toxicity high-throughput determination method, which comprises the following steps: performing exposure contamination on a tested organism by using a sewage sample to obtain phenotypic characteristic data of the tested organism; constructing a toxicity matrix; establishing a machine learning model, and determining the water quality comprehensive toxicity of the sewage sample in combination with the toxicity matrix. The water quality comprehensive toxicity determination method provided by the invention does not need sample concentration and enrichment, ensures the comprehensiveness and accuracy of the detection result, and can be applied to the comprehensive toxicity high-flux determination of the sewage in the whole process of a sewage treatment plant.

The invention discloses an 8-hydroxyquinoline derivative platinum complex as well as a synthesis method and application thereof. According to the invention, an 8-hydroxyquinoline derivative platinum complex is used as an active ligand and reacts with cis-Pt (DMSO) 2Cl2 to synthesize the 8-hydroxyquinoline derivative platinum complex. The 8-hydroxyquinoline derivative platinum complex has a good inhibition effect on human breast cancer cells MDA-MB-231, shows excellent in-vivo and in-vitro anti-tumor activity, has potential medicinal value, and is expected to be used for preparing various anti-tumor drugs.

The invention discloses a phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative as well as preparation and antibacterial application thereof. According to the series of compounds, phenanthro [9, 10-d] imidazole quaternary ammonium salt derivatives which are novel in structure and good in antibacterial activity are prepared by taking phenanthro quinone as a lead compound and modifying the structure of phenanthro quinone, the structural general formula of the phenanthro [9, 10-d] imidazole quaternary ammonium salt derivatives is shown in the specification, and R is selected from H, C6-C14 alkyl or C3-C8 alkylene. The phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative prepared by the invention has a relatively good antibacterial effect on gram-positive bacteria such as staphylococcus aureus S.aureus ATCC 29213 and various clinical methicillin-resistant staphylococcus aureus (MRSA), meanwhile, the water solubility is improved, the biotoxicity of a parent body is reduced, and the phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative has relatively high yield and is suitable for industrial production. The compound is expected to be further developed into a clinical candidate antibacterial drug. # imgabs0 #

The invention discloses a polydopamine modified and cupric peroxide loaded ZIF8 nano particle and application thereof, and belongs to the technical field of medicine preparation. According to the invention, a zeolite imidazoline framework 8 is used as a matrix, CuO2NPs is uniformly modified in the zeolite imidazoline framework 8 to form CuO2 (at) ZIF8NPs, and the surface of the CuO2 (at) ZIF8NPs is coated with a polydopamine film in the form of a film. The invention constructs multifunctional ZIF8NPs (CuO2 (at) ZIF8 (at) PDANPs) which is coated with PDA and loaded with CuO2NPs, and the multifunctional ZIF8NPs (CuO2 (at) ZIF8 (at) PDANPs is used for CDT of thermal enhancement OS. The CuO2 (at) ZIF8 (at) PDA NPs is combined with a photothermal effect and a chemodynamic therapy, shows good biocompatibility and an anti-tumor curative effect, has a potential application prospect in the aspect of osteosarcoma, and provides a new thought and method for treatment of osteosarcoma.

A hyaluronic acid derivative pharmaceutical composition comprising (A) a hyaluronic acid derivative into which a hydrophobic group is introduced, (B) an association promoter, and (C) an active ingredient. Preferably, the association accelerator (B) contains at least four ether structures (R-O-R), and satisfies the condition that the number of carbon atoms is 4 or more.

The invention relates to an HER2 (human epidermal growth factor receptor 2) targeting antibody coupling gold (III) porphyrin medicine as well as a synthesis method and tumor treatment application thereof. The antibody coupling gold (III) porphyrin drug targeting HER2 is formed by connecting an anti-HER-2 trastuzumab and an A3B type gold (III) porphyrin complex through a linker, and the linker comprises a maleimide joint connected with an antibody and a self-elimination joint connected with the A3B type gold (III) porphyrin complex. The A3B type gold (III) porphyrin complex with anti-tumor activity is combined with trastuzumab with a specific recognition function as a carrier, the antibody is utilized to accurately strike tumor cells, a medicine is delivered to a tumor environment, the tumor targeting property of the gold (III) porphyrin complex is improved, and accurate treatment is realized. Distribution of drugs in the body can be improved, accumulation of the drugs in non-tumor sites can be reduced, the dosage of metal complexes is reduced, and toxic and side effects are reduced; the efficient delivery of gold drugs to tumor tissues can also be realized, and the cancer treatment effect is improved.

The invention discloses an environmentally friendly aluminum paint stripper and a preparation method thereof in the field of paint stripper technology, including the following components by weight: 15-20 parts of alkaline substances, 8-10 parts of catalyst promoters, 6-8 parts of cosolvents, 3-5 parts of de-agent promoters, 3.6-4.6 parts of surfactants and 200-230 parts of deionized water. The present invention proposes to prepare a water-based environmentally friendly alkaline paint stripper by selecting a high-boiling-point low-toxicity component, thereby achieving the technical effect of paint stripper environmental protection, and preparing a catalyst promoter at the same time, connecting a carbon shell with nano-iron tetroxide as the core, loading an alkaline metal oxide, and improving the degradation rate of the paint film, thereby reducing the paint stripping time and reducing the substrate loss.

The invention provides a gold-copper nanocluster with efficient multi-source active oxygen generation performance and a preparation method and application of the gold-copper nanocluster, and belongs to the field of biomedical materials. The gold-copper nanocluster is synthesized through mediation of Tf, and Tf is full transferrin, iron-saturated transferrin or siderophore. The gold-copper nanocluster with Tf as the ligand is synthesized by adopting a simple one-pot method, and the problems that in the prior art, a multi-source active oxygen generation system is complex to construct and a preparation method is tedious are solved; the gold-copper nanocluster synthesized by taking Tf as a ligand can be used as a simple multi-source active oxygen generation system, superoxide anions can be generated through photosensitized oxidation activity sensitization oxygen, and hydroxyl radicals can be generated through peroxidase-like activity catalysis hydrogen peroxide, so that efficient generation of multi-source active oxygen is realized; and the effect of enhancing tumor treatment is achieved.

The invention belongs to the technical field of medical preparations, and particularly relates to a resveratrol-succinyl glycan-tetravalent platinum nano-drug as well as a preparation method and application of the resveratrol-succinyl glycan-tetravalent platinum nano-drug. In the resveratrol-succinyl glycan-tetravalent platinum nano-drug provided by the invention, the succinyl glycan (RIC) can exert the anti-tumor activity by improving the immune function of a body; resveratrol (RES) can be used for directly acting on related targets and the like to exert anti-tumor activity by inhibiting proliferation of tumor cells, inducing apoptosis of the tumor cells, inhibiting invasion and metastasis of the tumor cells and regulating the immune function of a body. According to the invention, the succinylglycan-tetravalent platinum conjugate is used for wrapping an anti-cancer drug micromolecule RES, so that the anti-cancer curative effect of the drug is improved, the problems of toxic and side effects of platinum drugs, drug resistance of tumor cells and the like are solved, and a new idea is provided for construction and application of platinum nano-drugs.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The application discloses a kind of low-carbon cementing material by waste incineration fly ash excited ore powder and preparation method thereof, by weight percentage, including the following components: modified waste incineration fly ash 8~12%, ion complex component 1~3%, composite shrinkage component 2~6%, ore powder 55~65%, water 23~28%.Preparation method includes the following steps: S1, preparation modified waste incineration fly ash, ion complex component, composite shrinkage component;S2, modified waste incineration fly ash, ion complex component, composite shrinkage component, ore powder, mixing water, fully mixed and stirred evenly, can obtain the low-carbon cementing material by waste incineration fly ash excited ore powder described in the application.In the aspect of component design, the application is environmentally friendly, low cost, in the performance aspect, the flow rate can be adjusted, the mechanical properties are excellent, the volume shrinkage is small.

A compound of formula (I), or a tautomer, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound represented by formula (I) or the tautomer, the stereoisomer or the pharmaceutically acceptable salt thereof, as a novel linker compound, can be used for preparing an ADC medicament with a high DAR value. The present invention also relates to an ADC medicament prepared from the linker.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention relates to the field of synthesis of pyrazolone, and provides a method for synthesizing a pyrazolone structure by utilizing carbon dioxide aiming at the problem that an expensive transition metal catalyst and high-toxicity carbon monoxide are needed for synthesizing pyrazolone by utilizing carbonylation reaction, and the reaction formula is as follows: # imgabs0 # reaction conditions are as follows: in the presence of carbon dioxide, in an organic solvent and under the action of alkali, the reaction is carried out for 1-3 hours, so that the pyrazolone structure is synthesized by utilizing carbon dioxide. And reacting the compound II with carbon dioxide to obtain the pyrazolone structure. According to the method, the pyrazolone structure is synthesized in a green and efficient manner by utilizing carbon dioxide.

The invention belongs to the technical field of organic synthesis, and discloses a preparation method of a rubbegron intermediate, which comprises the following steps: taking 2-chloropropane, phthalimide and p-hydroxybenzyl alcohol as main starting raw materials, reacting the phthalimide with the 2-chloropropane, and condensing with the p-hydroxybenzyl alcohol to obtain the rubbegron intermediate. And finally, carrying out hydrazinolysis to obtain the rubbegron intermediate 4-(2-amino-2-methylpropyl) phenol. The preparation method provided by the invention is a novel method for preparing the rubaburon intermediate, a high-toxicity reagent nitropropane in the existing literature is not used, a hydrogenation reaction of a key supervision process is also not adopted, and the method is safer from the aspects of reaction reagents and types.

The invention aims to provide a preparation method of a rubber hot water pipe. The preparation method comprises the following specific steps: 1) preparing a rubber composition containing rubber; 2) manufacturing a resin mixture composed of resin; (3) a resin mixture is mixed into the rubber composition, a rubber composition mixture is manufactured, and the weight ratio of the rubber composition to the resin mixture is 100: (10-30); and 4) melting the rubber composition mixture under the temperature condition of 210-250 DEG C, and molding to manufacture a pipeline molded product. According to the method, the pressure resistance, the heat resistance, the antibacterial property, the wear resistance, the impact resistance and other characteristics of the hot water pipe can be enhanced, the resistance to external impact is improved, and meanwhile the antibacterial property and the deodorization property of the hot water pipe are improved. Besides, the hot water pipe is made of elastic rubber materials, construction is easy, the vortex phenomenon generated in a bent or bent pipeline along with flowing of fluid can be reduced, and it is guaranteed that the fluid can be smoothly supplied.

The invention discloses an efficient synthesis method of 2-acetamido-pyridine-3-formic acid, which comprises the following steps: taking 2-amino-3-methylpyridine as a raw material, firstly reacting with acetic anhydride in a micro-channel reactor, and carrying out post-treatment to obtain 2-acetamido-3-methylpyridine; and then, carrying out catalytic oxidation on the intermediate in a water-ethanol system in an oxygen environment by taking iridium trichloride, copper 2-picolinate, N-hydroxyphthalimide and iodobenzene as a catalytic system. And filtering out and recovering the catalyst after the reaction, and carrying out two-step programmed cooling crystallization and activated carbon decoloration refining on mother liquor to obtain a high-purity target product. The method has the advantages of cheap raw materials, adoption of a green solvent and oxygen as oxidants, mild reaction conditions, high product yield and purity, few three wastes, recoverable catalyst, and facilitation of industrial production.

The application discloses a kind of hydrorefining catalyst activation methods of hydrocarbon oil.The method includes the process of reduction to hydrorefining catalyst of hydrocarbon oil, wherein, the hydrorefining catalyst includes alumina carrier, metal molybdenum, organic nickel and organic metal auxiliary agent, the metal auxiliary agent is at least one or several of zinc, copper, magnesium, gallium, with the weight of final hydrogenation catalyst as basis, the mass content of organic nickel is 0.1% to 4.0%, preferably 0.2% to 3.0%, further preferably 0.5% to 2.0%, with the metal auxiliary agent element as basis, the mass content of organic metal auxiliary agent is 0.05% to 2.5%, preferably 0.1% to 2.0%, further preferably 0.2% to 1.5%.The method has the advantages of time-saving and high efficiency, without adding sulfidation agent, and more simple and convenient to switch raw materials.

The invention discloses a preparation method of 3-oxo-4-androstene-17 beta-carboxylic acid, and belongs to the technical field of medicine synthesis. According to the invention, pregnenolone is used as an initial raw material, and is oxidized by an oxidant in the presence of a catalyst to obtain 3-oxo-4-androstene-17 beta-carboxylic acid. The method is simple and convenient to operate, mild in reaction condition, low in cost, high in yield and suitable for industrial large-scale production, and has great significance in production of epristeride bulk drugs.

The invention discloses a cross-linked netted water-soluble polymer paper reinforcing agent and a preparation method thereof, and belongs to the field of paper reinforcing, at 60-120 DEG C, a catalyst and an amino-containing cross-linking agent are added into a mixed solution dissolved with polyvinyl alcohol and sodium carboxymethyl cellulose while stirring, the catalyst is zinc chloride or aluminum chloride, and then heat preservation treatment is performed; and cooling the obtained reaction system, adding a silane coupling agent, then preserving heat for 0.5-2 hours, and adjusting the pH value of the obtained reaction system to be neutral to obtain the cross-linked network water-soluble polymer paper reinforcing agent, which has wide application prospects in the production of various types of paper (such as packaging paper, writing paper, printing paper and the like).

The invention discloses fructus cannabis cake meal functional peptide as well as a preparation method and application thereof, and belongs to the technical field of fructus cannabis processing. In order to solve the technical problems that in the prior art, the utilization rate, safety and digestibility of fructus cannabis cakes are low, the fructus cannabis cake functional peptide and the preparation method thereof are provided, through high-temperature extrusion puffing treatment and a two-step precipitation method, the extraction rate and digestibility of protein of the fructus cannabis cake functional peptide are increased, and the yield of the fructus cannabis cake functional peptide is increased. And the content of toxic substances is reduced. The fructus cannabis cake meal functional peptide provided by the invention has the functions of remarkably enhancing the phagocytic function of mouse mononuclear-macrophages, promoting spleen and thymus development of mice, improving the immune factor level in mice, reducing the inflammatory factor level in mice, promoting intestinal digestion and protecting intestinal tracts. The fructus cannabis cake meal functional peptide provided by the invention can be applied to immunosuppressive mouse in-vivo regulation and functional food preparation.

The invention belongs to the technical field of biological medicine, and relates to a BODIPY-based photosensitizer compounded platinum complex, a preparation method and application thereof, the BODIPY-based photosensitizer compounded platinum complex comprises a cis-platinum complex c-BBP or a counter-platinum complex t-BBP, the molecular formula of the cis-platinum complex c-BBP and the counter-platinum complex t-BBP is C36H42B2F4N8Pt, the molecular formula of the counter-platinum complex c-BBP is C36H42B2F4N8Pt, and the molecular formula of the counter-platinum complex t-BBP is C36H42B2F4N8Pt. The platinum complex is combined with a BODIPY photosensitizer and combined with PDT, the defects of platinum drugs are effectively overcome, the complex has an inhibiting effect on tumor cells, and a new direction is provided for development of new anti-cancer drugs.

A dual-targeting biomimetic liposome containing elemene and cabazitaxel. Every 100 mL of the dual-targeting biomimetic liposome containing elemene and cabazitaxel contains 0.15- 0.75 g of elemene, 0.5-2.5 mL of absolute ethanol, 0.015-0.07 g of cabazitaxel, 0.25-1 g of oil, 0.25-1 g of a polyethylene glycol derivative, 1-5 g of a phospholipid, 0.05-0.2 g of cholesterol, 0.025-0.1 g of DSPE-PEG2000-transferrin, and 0.005-0.025 g of a tumor cell membrane protein, with the balance being water. The two drugs have a synergistic effect, such that the BBB permeability of the drugs and the uptake rate of the drugs by glioma cells are improved, and the toxic side effects of cabazitaxel and the irritation of elemene are also reduced. The present disclosure further provides a A method for preparing the liposome and the use of the liposome.

The present invention relates to the technical field of catalysts, and discloses a close-coupled SCR catalyst and a preparation method and application thereof, wherein the catalyst comprises a molecular sieve and indium oxide; the indium oxide is loaded on the surface of the molecular sieve in the form of particles; the indium oxide is A x In 1‑x O y , wherein A is one or more selected from Ce, La, Pr, Nb, Ga, Ni, Gd, Zn, Cr, Sr, and Zr; In is indium; O is oxygen; 0≤x<1, and y is determined by the chemical formula balancing method of indium oxide. The catalyst obtained by the present invention not only effectively improves the catalyst's resistance to hydrocarbon poisoning, solves the problem of catalyst deactivation due to hydrocarbon poisoning in the ccSCR system, but also improves the catalyst's low-temperature activity, broadens the active temperature window and N 2 Selective.

The invention discloses a phosphorus-containing polymer and a preparation method and application thereof, the phosphorus-containing polymer comprises a repeating unit derived from an alpha, omega-non-conjugated diene monomer and a repeating unit derived from a phosphorus source monomer, the alpha, omega-non-conjugated diene monomer is selected from diallyl oligomeric ethylene glycol, diallyl piperazine, diallyl ether, octadiene and the like, and the phosphorus source monomer is selected from diallyl oligomeric ethylene glycol, diallyl piperazine, diallyl ether, octadiene and the like. The phosphorus source monomer is selected from hypophosphorous acid and hypophosphite. The lithium salt compound polyelectrolyte based on the phosphorus-containing polymer has quite high conductivity and can be used for a lithium ion battery; the polyphosphonate surfactant disclosed by the invention has the characteristics of chemical stability, biocompatibility, hydrophilicity and the like, and the alkyl phosphonate surfactant shows diversified functions and purposes; the flame retardant based on the phosphorus-containing polymer has excellent flame retardant property.

The present invention relates to the field of biomedicine, and specifically provides a lyophilized powder and nasal preparation containing neurotoxin, comprising neurotoxin, stabilizer and excipient; the excipient comprises one or more of acidic gelatin, alkaline gelatin and sucrose, and the stabilizer comprises one or more of block polyether F-68, block polyether F-127 and Tween 80; by using the stabilizer comprising one or more of block polyether F-68, block polyether F-127 and Tween 80 and the excipient comprising one or more of acidic gelatin, alkaline gelatin and sucrose, a synergistic effect is produced, so that the stability of the neurotoxin at room temperature is significantly improved, the degradation of the neurotoxin is slowed down, and the time for maintaining the biological activity of the neurotoxin at more than 95% is significantly prolonged, and at the same time, the preparation can be administered nasally, which increases the penetration of the neurotoxin through the blood-brain barrier and greatly reduces the toxicity.

The invention relates to the technical field of pharmaceutical and chemical engineering, in particular to a preparation method and application of an edoxaban intermediate, N-[(1R, 2R, 5S)-5-(dimethyl carbamoyl)-2-hydroxycyclohexyl]-5-methyl-4, 5, 6, 7-thiazolidine-5, 4-c] pyridine-2-formamide is used as a starting material, a solvent is added, the mixture is subjected to a reaction at the temperature of 60-80 DEG C, and the edoxaban intermediate is obtained. In the presence of alkali, an organic phosphorus reagent and a condensing agent, a compound 2 is generated through a Mitsunobu reaction with an N-Boc substituted sulfonamide compound, t-butyloxycarboryl is removed under an acidic condition to generate the edoxaban intermediate, the reaction conditions are mild, no harsh reaction conditions such as high temperature and low temperature exist, and the method is suitable for industrial production. The method can avoid the use of highly toxic and poor-safety sodium azide, has the characteristics of good regioselectivity, high optical purity, simplicity in purification, low cost and the like, and has a very good industrial production prospect.