5results about How to "Increased toxicity" patented technology

The application discloses a kind of low-carbon cementing material by waste incineration fly ash excited ore powder and preparation method thereof, by weight percentage, including the following components: modified waste incineration fly ash 8~12%, ion complex component 1~3%, composite shrinkage component 2~6%, ore powder 55~65%, water 23~28%.Preparation method includes the following steps: S1, preparation modified waste incineration fly ash, ion complex component, composite shrinkage component;S2, modified waste incineration fly ash, ion complex component, composite shrinkage component, ore powder, mixing water, fully mixed and stirred evenly, can obtain the low-carbon cementing material by waste incineration fly ash excited ore powder described in the application.In the aspect of component design, the application is environmentally friendly, low cost, in the performance aspect, the flow rate can be adjusted, the mechanical properties are excellent, the volume shrinkage is small.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

The invention discloses a traditional Chinese medicine compound cell culture fluid and application thereof. The traditional Chinese medicine compound cell culture fluid comprises a basic culture medium, and 1 L of the basic culture medium contains 2-10 mg of notoginsenoside R1, 1-5 mg of notoginsenoside Rb1, 1-5 mg of notoginsenoside Rg1, 0.1-1 mg of notoginsenoside Rg3, 0.5-2 mg of notoginsenoside Re, 1-6 [mu] g of shikonin, 5-15 [mu] g of cordycepin and 1-20 mg of basil polysaccharide. In the traditional Chinese medicine compound cell culture fluid, notoginsenoside Rg3 can be combined with shikonin, so that the cytotoxicity can be enhanced, cord blood NK cells are promoted to be differentiated to mature functional phenotypes with high cytotoxic activity, and the killing efficiency of the NK cells on various tumor target cells is remarkably improved; the notoginsenoside Rb1 is combined with the basil polysaccharide, so that the NK cells can be driven to expand and grow, the activity of the NK cells can be maintained, and the cell purity can be improved, so that the persistence of the cell activity can be enhanced, and the tumor killing rate of the NK cells can be improved.

This invention discloses a double-layer composite ceramic fiber filter tube with functions of flue gas dust removal, nitrous oxide removal, and dioxin removal, and its preparation method. The ceramic fiber tube consists of an outer filter layer and an inner catalyst layer. The ceramic fiber tube provided by this invention has high dust removal efficiency at 150℃~400℃, high nitrous oxide removal efficiency, and high dioxin removal efficiency. The preparation process is simple and has few steps. The active components are uniformly dispersed on the carrier, with adjustable loading and high bonding strength. This material can achieve integrated treatment of dust, nitrous oxide, and dioxins, efficiently simplifying the treatment process of industrial exhaust gas purification and reducing flue gas treatment costs.