47 results about "Charged polymers" patented technology

The invention discloses a functionalized nano magnetic iron-based material as well as a preparation method and application thereof. The functionalized nano magnetic iron-based material comprises a magnetic Fe3O4 core, a SiO2 isolating layer, a polydopamine electron transfer strengthening layer and a positively charged polymer three-dimensional microspace conducting layer, the magnetic Fe3O4 core, the SiO2 isolating layer, the polydopamine electron transfer strengthening layer and the positively charged polymer three-dimensional microspace conducting layer are sequentially arranged from inside to outside. According to the invention, rapid recovery of materials is realized through design of magnetic components (sedimentation time lt; 5 min) and cyclic utilization (more than or equal to 10 times); the dispersibility of the material and the affinity of microorganisms are improved through surface functionalization design; and the starting period is shortened by more than 50% through an electron transfer process strengthening and directional microorganism enrichment synergistic interaction mechanism.

The invention discloses a gamma-glutamyl transpeptidase catalytic hydrolysis induced charge upset polymer, which contains a gamma-glutamyl transpeptidase response element part and a fluorescent probe corresponding fragment part, the invention also discloses a preparation method of the polymer for turning charge by catalytic hydrolysis of gamma-glutamyltranspeptidase and an application method of the polymer in the field of tumor imaging. According to the present invention, the gamma-glutamyltranspeptidase catalytic hydrolysis electric charge overturning polymer is adopted as the response type tumor imaging probe, such that the electric charge can be converted from the negative or neutral state to the positive state so as to achieve the rapid uptake of the positively charged polymer by the tumor cells so as to achieve the rapid spraying imaging, and the probe response after the uptake is adopted so as to achieve the rapid spraying imaging; the imaging effect of the probe on the tumor is greatly improved, and the probe has important significance in solid tumor imaging for assisting a doctor in surgical resection.

The invention discloses a two-dimensional heterogeneous self-assembled film and a preparation method thereof. The preparation method comprises the following steps: successfully synthesizing Fe3O4-COOH nanoparticles which are uniform in morphology and stable in size and have carboxyl modified surfaces by adopting an improved solvothermal method; then, the surface of the Fe3O4-COOH is modified with a layer of positively charged polymer BPEI through the electrostatic adsorption effect, and Fe3O4 (at) BPEI is formed; the preparation method comprises the following steps: preparing Fe3O4 (at) BPEI (at) Au, further uniformly adsorbing (12nm) gold nanoparticles on the surface of the Fe3O4 (at) BPEI (at) Au through electrostatic adsorption, finally forming a stable gold shell structure, constructing Fe3O4 (at) BPEI (at) Au with a magnetic core gold shell structure, modifying sulfydryl polystyrene (SH-PS) on the surface of the Fe3O4 (at) BPEI (at) Au, successfully preparing a two-dimensional heterogeneous self-assembled film by taking the Fe3O4 (at) BPEI (at) Au as a construction unit, and constructing the two-dimensional heterogeneous self-assembled film by taking the Fe3O4 (at) BPEI (at) Au as the construction unit. The two-dimensional heterogeneous self-assembled thin film shows good SERS enhancement performance and uniformity, and shows SERS signal sensitization capacity under the action of an external magnetic field.

The invention discloses a charged hollow fiber loose nanofiltration membrane as well as a preparation method and application thereof. The hollow fiber nanofiltration membrane comprises a supporting layer and a charged separation layer, and the charged separation layer is attached to the inner surface of the hollow fiber supporting layer and is co-extruded and molded by adopting a double-layer spinneret plate; the charge separation layer comprises a charge polymer and a matrix polymer, and a positively charged polymer or a negatively charged polymer is selected according to an entrapment dye; the negatively charged separation layer further comprises hydroxylated polyether sulfone; the charged hollow fiber loose nanofiltration membrane is prepared by preparing an inner-layer membrane casting solution and an outer-layer membrane casting solution, carrying out co-extrusion molding through a double-layer spinneret plate, carrying out phase inversion membrane formation and then carrying out post-treatment. During application, corresponding charged nanofiltration membranes can be selected according to the electrical properties of dyes in sewage, efficient selective interception of different charged dyes is achieved, meanwhile, high transmittance is achieved for inorganic salt, the technological process of a one-step continuous forming process is simplified, the production efficiency is high, the method can be compatible with an existing hollow fiber membrane production line, and industrialization is easy to achieve.

Compositions including fusion proteins, viruses, and a synthetic charged polymer are provided. The composition includes a fusion protein reagent, one or more viral particles, and synthetic charged polymer, where the fusion protein reagent includes an affinity domain and a polypeptide with phase behavior, and where a molar ratio of the synthetic charged polymer to the fusion protein reagent is 400: 1 to 4: 1. The compositions may be used to control viral transduction. The compositions may be used to improve viral transduction. Methods of using the compositions to control of viral transduction and improve viral transduction are described.

Charged polymeric webs, such as electret webs, include a thermoplastic resin and a charge-enhancing additive. The additives are substituted heterocyclic thiolate salts. The heterocyclic thiolate salt has 2 nitrogen groups and a third group that may be an NH, N—NH2, O, or S group. The substituent group is an aromatic or heterocyclic aromatic group. The electret webs may be a non-woven fibrous web or a film. The electret webs are suitable for use as filter media.

The invention discloses a soybean protein-phospholipid biomimetic membrane as well as a preparation method and application thereof. The biomimetic membrane is formed by three raw materials of soybean protein, soybean lecithin and a charged polymer through electrostatic interaction and a physical blending method. The soybean 11s protein solution, the lipidosome dispersion liquid and the charged polymer solution are mixed to obtain the mosaic structure biomimetic membrane which is formed by combining various chemical bond crosslinking and electrostatic interaction, and the process conditions are simple, efficient, convenient and environmentally friendly. The biomimetic membrane provided by the invention has a mosaic structure and the characteristics of the raw materials, so that the biomimetic membrane has high ion passing rate, strong ion selection capability, excellent monovalent cation and divalent cation separation capability and certain biodegradability. When the biomimetic membrane is applied to ion separation, the separation capacity of ions with different valence states can be effectively improved, the separation effect of sodium ions and magnesium ions is optimal, and the separation factor is as high as 21.28 and is 54.6 times that of a biomimetic membrane without charges.

The present invention relates to the technical field of mixed matrix membranes, and in particular to a crown ether-loaded UiO-66-NH2 mixed matrix membrane and its preparation method and application. The preparation method comprises: adding glacial acetic acid to a zirconium tetrachloride solution to obtain solution one; adding a crown ether to a 2,5-diaminoterephthalic acid solution to obtain solution two; mixing solution one and solution two and performing a hydrothermal reaction to obtain crown ether-loaded UiO-66-NH2; dispersing a positively charged polymer and crown ether-loaded UiO-66-NH2 in an organic solvent, mixing and forming a liquid film, and obtaining a crown ether-loaded UiO-66-NH2 mixed matrix membrane. The crown ether-loaded UiO-66-NH2 mixed matrix membrane of the present invention has good ion recognition ability, overcomes the defect of low selectivity of traditional polymer membranes; and overcomes the shortcomings of the existing chemical reaction grafting method, such as complex reaction process and high raw material cost, through in-situ coating technology.

A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

The present invention provides methods for characterizing the composition of polymers. Common to these methods, the subunits of a charged polymer strand are moved by the force of electrophoresis across closely spaced electrodes so as to produce tunneling currents modulated by their passage and indicative of their chemical structure. Comparisons of the electronic signals thus obtained to those of known standards that have undergone similar electrophoresis are made so as to determine the composition of the polymer and the linear sequence of its subunits.The invention described here may be used for: the detection and identification of biological agents that may be pathogenic; the sequencing of small linear RNAs that may be present in cells and those that have been linearized by the methods described herein; and the sequencing of linear genomic DNA, mRNAs, linear non-coding RNAs, and polypeptides.

The utility model relates to a kind of packaging structure of fast-charging polymer lithium ion battery, comprising: battery main body, the upper end of which is equipped with tab;Protection plate, is located in the upper end of the battery main body, the lower end surface of the tab is electrically connected after being bent;Plastic package part, is covered in the outside of the protection plate and tab;And connecting piece, with the upper end surface of the protection plate fixed connection, the connecting piece is bent and extends to the side of the battery main body after extending outwards and passing through the plastic package part, and is connected with the side of the battery main body.The utility model can connect the upper end surface of protection plate with the side of battery main body, form support, guide and disperse the stress on the tab of existing plastic package structure to the side of more stable battery main body, to enhance the overall stability and reliability of plastic package structure.

A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

In the present invention, positively charged cerium hydroxide particles without undergoing surface charge treatment are subjected to ultrasonic agitation, so that a negatively charged polymer or monomer and the cerium hydroxide particles form a coordination bond, thereby forming a first surface coating layer and reversing the surface charge into a negative charge; and in a second coating step, a weakly positively charged polymer is added, so that by means of charge attraction, a polymeric ion pair is formed, thereby achieving a second charge reversal to a positive charge. Disclosed in the present invention is a method for multiple surface coatings of cerium hydroxide particles. The coated cerium hydroxide particles do not change the intrinsic electrical properties thereof, and can greatly reduce defects caused by mechanical forces during polishing, such as particle adhesion, thereby improving the product yield.

This invention relates to a monovalent selective anion exchange membrane, its preparation method, and its application. The preparation method includes the following steps: placing the anion exchange base membrane in an electrodeposition solution for electrodeposition; the electrodeposition solution includes a negatively charged polymer and a neutral salt; then placing it in an oxidant solution for a chelation reaction; and finally placing it in a polymer monomer solution for polymerization to obtain the monovalent selective anion exchange membrane. This invention, through sequential electrodeposition, chelation, and polymerization reactions, utilizes the active sites formed by the chelation reaction between the negatively charged layer and the oxidant to regulate the directional polymerization of the polymer, forming a dense polymer-modified layer. This avoids polymer clogging of the anion exchange base membrane pores, achieving high ion selectivity, effectively weakening the trade-off effect between flux and selectivity of the monovalent selective anion exchange membrane, and exhibiting good antifouling performance.

A nanopore is provided having a charged polymer attached thereto. At least one end of the charged polymer is fixed at or near one end of the channel of the nanopore in a position that allows the charged polymer to enter the channel. The charged polymer may optionally be fixed in a threaded configuration. When in a threaded configuration, the charged polymer increases the electrical conductivity of the nanopore while still allowing other polymers (such as nucleic acids or polymer tags of tagged nucleotides) to flow through the channel of the nanopore.

A biologic composition for promoting wound healing includes: a human mesenchymal stem cell (MSC)-derived extracellular matrix (ECM) biologic component, and a negatively charged polymer, combined with the biologic component to form the biologic composition. A method of preparing the biologic composition thereof includes: (i) isolating human mesenchymal stem cells (MSC) and subjecting the MSC to hypoxia-priming in a xeno- and / or serum-free, or chemically defined medium to stimulate the production of an MSC-derived biologic component with pro-angiogenic factors; (ii) aggregating and co-precipitating the MSC-derived biologic component with a negatively charged polymer into a pericellular space of the MSC to produce an aggregated biologic component; (iii) assembling the aggregated biologic component and the negatively charged polymer into an insoluble extracellular matrix (ECM) by the MSC; and (iv) decellularizing the insoluble ECM to obtain the biologic composition comprising MicroParticles of Solidified Secretome (MIPSOS).

The invention discloses a negative plate with a directional gradient pore structure, a composite pore-forming agent for preparing the negative plate, a preparation method and a lithium ion battery, the composite pore-forming agent has a core-shell coating structure and a surface functionalization modification layer, the core-shell coating structure comprises an inner core and an outer shell coating the outer surface of the inner core; wherein the inner core is a thermal decomposition type pore-forming material, and the thermal decomposition type pore-forming material can be subjected to thermal decomposition in a temperature range of 80-120 DEG C and release gas; the shell is a thermal dissolution type polymer coating layer, and the surface functionalization modification layer is a charged polymer layer and uniformly coats the outer surface of the shell, so that the composite pore-forming agent is endowed with surface charge characteristics. According to the invention, the composite pore-forming agent combining core-shell coating and surface functional modification is designed and is matched with an electric field-assisted gradient sedimentation and segmented heating pore-forming process, so that directional gradient regulation and control of a pore structure in the thickness direction of the pole piece are realized in a single pore-forming agent system.

The invention provides a high-solid-content preparation method of a cyclic polymer brush and the prepared cyclic polymer brush. The preparation method comprises the following steps: obtaining a polymer brush precursor, wherein the polymer brush precursor has a group A, a group B, a group C and a group D; wherein the group A and the group B exist on the main chain, and the group C and the group D exist on the main chain and / or the side chain; reacting the charged reaction reagent with at least a part of groups C of the polymer brush precursor to convert at least a part of groups C into charged groups to obtain a charged polymer brush precursor; carrying out intramolecular cross-linking reaction on the group D and a dynamic cross-linking agent to obtain nano-particles formed by a cross-linked polymer brush precursor; the group A and the group B of the cross-linked polymer brush precursor are subjected to a ring-closing reaction to form a ring structure, and at least part of side chains exist on the ring structure; and releasing intramolecular crosslinking of the crosslinked polymer brush precursor, and optionally removing the charged groups to obtain the annular polymer brush.

The invention discloses a preparation method of a positive electrode material, and the preparation method comprises the following steps: carrying out polymerization reaction on a polymer monomer to obtain a positively charged doped polymer, and carrying out dedoping and purification treatment to obtain positively charged polymer particles; dispersing the polymer particles in a non-polar solvent to obtain a polymer suspension, and dispersing a negatively charged positive electrode matrix material in a polar solvent to obtain a matrix suspension; and mixing the polymer suspension and the matrix suspension, adsorbing positively charged polymer particles on the surface of a negatively charged positive electrode matrix material through charge interaction, and separating and drying to obtain the positive electrode material of which the surface is coated with the polymer. Through the surface coating, the normal-temperature cycling stability is remarkably improved, reversible overheating protection at high temperature is realized, and the core contradiction between high capacity and insufficient safety of the positive electrode material is effectively solved.

The application discloses a kind of magnetic microspheres and its preparation method and application in detection, belong to the field of biological detection magnetic material.The present application takes charged polymer microspheres as core, through solvent-thermal method or electrostatic interaction to coat magnetic particle, then through Stober method to coat silicon layer and build charged interface, then composite nano emulsion microspheres on the surface of silicon layer, through high-temperature melting and flattening to form dense and uniform polymer outer layer, finally obtain multilayer sandwich structure magnetic polymer microspheres.The method of the present application simplifies process, and surface interface is easily controlled, and the microspheres prepared have the advantages of uniform particle size, controllable size, adjustable magnetism, high stability, low non-specific adsorption, etc., and are especially suitable for in vitro diagnostic detection field.

This application discloses a method and apparatus for preparing formaldehyde-free decorative paper impregnated with aqueous polyacrylate, belonging to the field of decorative paper production technology. The method includes: providing continuously running formaldehyde-free decorative paper; establishing an asymmetric pulsed electric field within a reactor impregnated with an aqueous polyacrylate emulsion along the path of the formaldehyde-free decorative paper; and controlling the formaldehyde-free decorative paper to pass through the reactor, so that negatively charged polymer micelles in the aqueous polyacrylate emulsion, under the action of the asymmetric pulsed electric field, overcome electrostatic repulsion and surface tension, and are forcibly and rapidly penetrate and fill the internal fiber network of the formaldehyde-free decorative paper. This application fundamentally solves the technical problem of the difficulty in deeply and uniformly impregnating the base paper with environmentally friendly aqueous resin under high-speed production conditions by introducing an electrodynamic forced penetration mechanism.

A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

The invention relates to a glucose responsive positive charge polymer-insulin compound as well as a preparation method and application thereof. Specifically, the invention discloses a glucose-responsive positive charge polymer with ultra-long-acting blood glucose control capability, the glucose-responsive positive charge polymer can be combined with insulin through electrostatic interaction to form a polymer-insulin compound, and the compound can be used for preparing drugs or preparations for treating diabetes. The polymer-insulin compound disclosed by the invention can release insulin to reduce blood sugar under high blood sugar concentration, and store insulin when the blood sugar level is normal, so that a hypoglycemia event is avoided, the treatment time of single administration is effectively prolonged, and therefore, the polymer-insulin compound can be used for controlling blood sugar in the treatment of diabetes and related diseases thereof.

A separator for a battery comprising: a porous glass fiber substrate having a first major surface and an opposing second major surface, and particles of a negatively charged polymer, wherein the particles are distributed in the porous glass fiber substrate such that a concentration of the particles increases throughout a thickness of the porous glass fiber substrate from the first major surface to the second major surface thereof. Further relating to a battery comprising the separator and a method for producing the separator.

A nucleic acid detection method comprises the steps of: inputting a sample containing nucleic acids into a vessel coated with a thin film comprising a cationic polymer having a hydrolyzable side chain; forming a polymer-nucleic acid complex by binding the nucleic acids to the cationic polymer which has been dissolved from the thin film; releasing the nucleic acids from the polymer-nucleic acid complex by hydrolyzing the cationic polymer; and amplifying the nucleic acids or other nucleic acids synthesized from said nucleic acids. The nucleic acid detection method may be carried out in a single pot, may reduce the detection time, and may improve detection accuracy.

The invention provides an oral drug delivery system and application thereof in the field of PAL delivery. According to the invention, DMSN-loaded PAL is taken as a core and is self-assembled with different charged polymers layer by layer through electrostatic interaction, the surface of the core is coated with a multi-layer polymer coating, and then nano-particles are encapsulated by adopting enteric capsules, so that the nano-particles can pass through the stomach to reach the small intestine absorption part in a complete particle form. An oral PAL delivery system which is stable in structure and synergetic in function is constructed. According to the PAL oral delivery system provided by the invention, the resistance of the PAL oral delivery system in intestinal tracts is enhanced, the penetrability of a mucous layer loaded with the PAL is improved, the complex environment in gastrointestinal tracts can be overcome, the PAL oral delivery system is transferred to blood through intestinal epithelial cells to play a role, and good bioavailability and biocompatibility are shown. The method is free of chemical modification, the preparation method is simple, reaction conditions are mild, use of toxic chemical reagents and potential damage to PAL enzyme activity are avoided, and a new PAL administration mode is provided.

This application provides surface-charged polymer nanoparticles, their synthesis method, and applications. The synthesis method for the charged polymer nanoparticles includes: adding a thiocarbonate chain transfer agent, a charged monomer, an aromatic monomer containing at least two benzene rings, and an initiator to a mixture of water and an organic solvent to obtain a mixture; heating the mixture in a vacuum-sealed environment, and obtaining surface-charged polymer nanoparticles through a polymerization reaction and self-assembly process, wherein the charged monomer is a monomer with a single charge type.

The application discloses a composite sodium-ion positive electrode material and a preparation method thereof; in the preparation, iron-based Prussian blue FeHCF is prepared through co-precipitation, and then a polyanion shell is coated through hydrothermal reaction; the inner core of the prepared Prussian blue is surface-modified, the surface modification comprises the following steps: using a positively charged polymer to make the surface of the Prussian blue positively charged through electrostatic adsorption, or using a coupling agent to introduce functional groups such as amino groups, so that the adsorption capacity of the surface of the Prussian blue to polyanion precursor ions is enhanced, and the growth of a uniform and dense shell is promoted. In the composite structure positive electrode material with the core of Prussian blue and the shell of polyanion provided by the application, the inner core Prussian blue plays a role in high capacity and excellent rate performance; the outer shell polyanion mainly plays a role in physical barrier and stable interface, the stable structure and excellent cycle performance of the polyanion material are used to provide a solid 'protective shell' for the whole particle, reduce the structural damage in the cycle process, and improve the overall cycle life.

A nucleic acid detection method comprises the steps of: inputting a sample containing nucleic acids into a vessel coated with a thin film comprising a cationic polymer having a hydrolyzable side chain; forming a polymer-nucleic acid complex by binding the nucleic acids to the cationic polymer which has been dissolved from the thin film; releasing the nucleic acids from the polymer-nucleic acid complex by hydrolyzing the cationic polymer; and amplifying the nucleic acids or other nucleic acids synthesized from said nucleic acids. The nucleic acid detection method may be carried out in a single pot, may reduce the detection time, and may improve detection accuracy.

The application provides a gas guiding device and a semiconductor device, and relates to the technical field of semiconductors. The gas guiding device comprises a first pipeline, an ion generator and a guiding member. The first pipeline has an air inlet end and an air outlet end. The ion generator is arranged on the outer side wall of the first pipeline and is close to the air inlet end, and is used for charging a polymer in the gas entering the first pipeline from the air inlet end. The guiding member is arranged on the inner side wall of the first pipeline and is close to the air outlet end, and is used for guiding the charged polymer to move towards the air outlet end. The gas guiding device can effectively avoid the accumulation of carbon-containing polymers on the inner wall of the pipeline.