69 results about "Charged polymers" patented technology

The invention discloses a multifunctional coating with a compact-porous double-layer structure on the surface of magnesium alloy and a preparation method, and belongs to the technical field of biological materials. According to the multifunctional coating, magnesium alloy serves as a substrate, a compact layer and a porous layer are sequentially stacked from the substrate to the outside, and the compact layer is composed of two-dimensional transition metal carbide / nitride, calcium silicate nanowires and a positively charged polymer. The porous layer is composed of copper-containing complex / biopolymer composite fibers, mineralized silk fibers loaded with bioactive metal ions and astragalus polysaccharide on the surface, and natural polymers. According to the multifunctional coating with the compact-porous double-layer structure prepared on the surface of the magnesium alloy, the porous layer on the surface layer has a unique porous structure, growth and proliferation of osteoblasts can be well promoted, meanwhile, the multifunctional coating has the characteristics of pressure resistance, bacteria resistance and oxidation resistance, the compact layer on the bottom layer can improve the corrosion resistance of the magnesium alloy, and the service life of the magnesium alloy is prolonged. The coating is particularly suitable for surface coating of magnesium alloy implant materials and can be used in the field of medical instruments.

The invention discloses a preparation method of a layer-by-layer casting ultrathin asymmetric bipolar membrane, and belongs to the technical field of membrane separation. The invention aims to solve the problems that the total thickness of the traditional bipolar membrane is small, the water decomposition rate is low, and the conversion efficiency of different salts is obviously different. The asymmetric bipolar membrane is prepared by using a layer-by-layer casting method, and the thickness of the anion exchange layer and the cation exchange layer of the membrane is regulated, so that ion leakage is avoided, and the product purity is remarkably improved; the anion-cation exchange layer is prepared from a polymer with charge, and the adhesion capacity of the membrane is greatly improved by virtue of electrostatic attraction through the characteristic of opposite charge of the anion-cation exchange layer, so that the membrane is prevented from swelling in water. According to the invention, the anion and cation exchange membranes are adhered together through electrostatic adsorption force by virtue of the characteristic of opposite charges, the adhesion strength of the membrane is enhanced by virtue of the chemical compatibility of SPPSU and QPPO, the membrane has good mechanical property, and the service time and frequency of the membrane are improved.

The invention discloses a functionalized nano magnetic iron-based material as well as a preparation method and application thereof. The functionalized nano magnetic iron-based material comprises a magnetic Fe3O4 core, a SiO2 isolating layer, a polydopamine electron transfer strengthening layer and a positively charged polymer three-dimensional microspace conducting layer, the magnetic Fe3O4 core, the SiO2 isolating layer, the polydopamine electron transfer strengthening layer and the positively charged polymer three-dimensional microspace conducting layer are sequentially arranged from inside to outside. According to the invention, rapid recovery of materials is realized through design of magnetic components (sedimentation time lt; 5 min) and cyclic utilization (more than or equal to 10 times); the dispersibility of the material and the affinity of microorganisms are improved through surface functionalization design; and the starting period is shortened by more than 50% through an electron transfer process strengthening and directional microorganism enrichment synergistic interaction mechanism.

The invention discloses a gamma-glutamyl transpeptidase catalytic hydrolysis induced charge upset polymer, which contains a gamma-glutamyl transpeptidase response element part and a fluorescent probe corresponding fragment part, the invention also discloses a preparation method of the polymer for turning charge by catalytic hydrolysis of gamma-glutamyltranspeptidase and an application method of the polymer in the field of tumor imaging. According to the present invention, the gamma-glutamyltranspeptidase catalytic hydrolysis electric charge overturning polymer is adopted as the response type tumor imaging probe, such that the electric charge can be converted from the negative or neutral state to the positive state so as to achieve the rapid uptake of the positively charged polymer by the tumor cells so as to achieve the rapid spraying imaging, and the probe response after the uptake is adopted so as to achieve the rapid spraying imaging; the imaging effect of the probe on the tumor is greatly improved, and the probe has important significance in solid tumor imaging for assisting a doctor in surgical resection.

The invention discloses a two-dimensional heterogeneous self-assembled film and a preparation method thereof. The preparation method comprises the following steps: successfully synthesizing Fe3O4-COOH nanoparticles which are uniform in morphology and stable in size and have carboxyl modified surfaces by adopting an improved solvothermal method; then, the surface of the Fe3O4-COOH is modified with a layer of positively charged polymer BPEI through the electrostatic adsorption effect, and Fe3O4 (at) BPEI is formed; the preparation method comprises the following steps: preparing Fe3O4 (at) BPEI (at) Au, further uniformly adsorbing (12nm) gold nanoparticles on the surface of the Fe3O4 (at) BPEI (at) Au through electrostatic adsorption, finally forming a stable gold shell structure, constructing Fe3O4 (at) BPEI (at) Au with a magnetic core gold shell structure, modifying sulfydryl polystyrene (SH-PS) on the surface of the Fe3O4 (at) BPEI (at) Au, successfully preparing a two-dimensional heterogeneous self-assembled film by taking the Fe3O4 (at) BPEI (at) Au as a construction unit, and constructing the two-dimensional heterogeneous self-assembled film by taking the Fe3O4 (at) BPEI (at) Au as the construction unit. The two-dimensional heterogeneous self-assembled thin film shows good SERS enhancement performance and uniformity, and shows SERS signal sensitization capacity under the action of an external magnetic field.

The present disclosure provides analyte sensors comprising a sensing layer disposed upon a surface of a first working electrode, wherein the sensing layer comprises an NAD(P)-dependent enzyme and a supply of NAD(P); and a multilayered membrane that overcoats at least a part of the sensing layer and is permeable to an analyte, wherein the membrane comprises at least one layer of negatively charged polymer. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.

The present invention discloses a super-slippery anti-fouling and drag-reducing composite coating with photothermal responsiveness, its preparation method and applications. The super-slippery anti-fouling and drag-reducing composite coating includes: a base layer, a homogeneous heat-absorbing layer, a porous heat-absorbing layer and a thermoresponsive super-slippery layer formed in sequence on the surface of a substrate; wherein, the base layer includes a positively charged polymer, an adhesive and a filler; the homogeneous heat-absorbing layer includes a hydrophobic resin, a negatively charged polymer and light-absorbing particles; the porous heat-absorbing layer includes a hydrophobic resin and light-absorbing particles, and the porous heat-absorbing layer has a porous structure; the thermoresponsive super-slippery layer includes paraffin and temperature-responsive polymer microcapsules encapsulating an anti-fouling agent. The super-slippery anti-fouling and drag-reducing composite coating with photothermal responsiveness provided by the present invention has a strong bonding force with the substrate, and also has the functions of storing a thermoresponsive phase change material, anti-fouling property and super-slippery property; at the same time, the preparation method provided by the present invention has the advantages of wide application range and large-area coating.

The invention discloses a charged hollow fiber loose nanofiltration membrane as well as a preparation method and application thereof. The hollow fiber nanofiltration membrane comprises a supporting layer and a charged separation layer, and the charged separation layer is attached to the inner surface of the hollow fiber supporting layer and is co-extruded and molded by adopting a double-layer spinneret plate; the charge separation layer comprises a charge polymer and a matrix polymer, and a positively charged polymer or a negatively charged polymer is selected according to an entrapment dye; the negatively charged separation layer further comprises hydroxylated polyether sulfone; the charged hollow fiber loose nanofiltration membrane is prepared by preparing an inner-layer membrane casting solution and an outer-layer membrane casting solution, carrying out co-extrusion molding through a double-layer spinneret plate, carrying out phase inversion membrane formation and then carrying out post-treatment. During application, corresponding charged nanofiltration membranes can be selected according to the electrical properties of dyes in sewage, efficient selective interception of different charged dyes is achieved, meanwhile, high transmittance is achieved for inorganic salt, the technological process of a one-step continuous forming process is simplified, the production efficiency is high, the method can be compatible with an existing hollow fiber membrane production line, and industrialization is easy to achieve.

Compositions including fusion proteins, viruses, and a synthetic charged polymer are provided. The composition includes a fusion protein reagent, one or more viral particles, and synthetic charged polymer, where the fusion protein reagent includes an affinity domain and a polypeptide with phase behavior, and where a molar ratio of the synthetic charged polymer to the fusion protein reagent is 400: 1 to 4: 1. The compositions may be used to control viral transduction. The compositions may be used to improve viral transduction. Methods of using the compositions to control of viral transduction and improve viral transduction are described.

Charged polymeric webs, such as electret webs, include a thermoplastic resin and a charge-enhancing additive. The additives are substituted heterocyclic thiolate salts. The heterocyclic thiolate salt has 2 nitrogen groups and a third group that may be an NH, N—NH2, O, or S group. The substituent group is an aromatic or heterocyclic aromatic group. The electret webs may be a non-woven fibrous web or a film. The electret webs are suitable for use as filter media.

The invention discloses a modified non-woven fabric, a filter element containing the modified non-woven fabric, a preparation method of the filter element and a water purifier. The modified non-woven fabric is characterized in that a modified layer is arranged on the non-woven fabric, and the modified layer is formed by first molecular chains and second molecular chains which are alternated; the first molecular chain comprises a structure formed by combining an amine monomer, a cross-linking agent and a charged polymer through chemical bonds; the second molecular chain comprises a structure formed by combining an amine monomer, a cross-linking agent and an uncharged polymer through chemical bonds; the ratio of the molecular weight of the charged polymer to the molecular weight of the non-charged polymer is 1: (1-1.5). The modified non-woven fabric can continuously and efficiently remove heavy metal, retain mineral substances and inhibit bacterial breeding, when the modified non-woven fabric is used in a filter element, the size of the filter element cannot be too large, the water flux of the filter element cannot be affected, on the contrary, structural parts of a filter element combination part can be reduced, and the cost of the filter element is reduced.

A multi-layer (multi-lamellar) coated nanoparticle is provided wherein the nanoparticle comprises a first coat comprising a positively charged polymer or a positively charged lipd bilayer and a second coat comprising an anionic bilayer and optionally one or more distinct cargo molecules, one or more distinct targeting moieties, or any combination thereof, as well as methods of making and using the nanoparticle.

The present invention discloses an anti-corrosion, anti-fouling and drag-reducing composite coating, a preparation method thereof and an application. The anti-corrosion, anti-fouling and drag-reducing composite coating comprises a base layer, a corrosion barrier layer, a connection layer and a flexible anti-fouling layer which are sequentially formed on the surface of a substrate; wherein, the base layer comprises an adhesive resin, a positively charged polymer, a filler and a diluent; the corrosion barrier layer comprises a flexible polymer resin, a negatively charged polymer and two-dimensional nanosheets; the connection layer comprises an adhesive resin, a positively charged polymer, a filler and a connecting agent; the flexible anti-fouling layer comprises a flexible polymer resin and temperature-responsive polymer microcapsules encapsulating an anti-fouling agent. The anti-corrosion, anti-fouling and drag-reducing composite coating in the present invention has a strong bonding force with the substrate and also has anti-corrosion, anti-fouling and drag-reducing properties; meanwhile, the preparation method provided by the present invention has the advantages of wide application range, large-area coating, etc.

The invention discloses a soybean protein-phospholipid biomimetic membrane as well as a preparation method and application thereof. The biomimetic membrane is formed by three raw materials of soybean protein, soybean lecithin and a charged polymer through electrostatic interaction and a physical blending method. The soybean 11s protein solution, the lipidosome dispersion liquid and the charged polymer solution are mixed to obtain the mosaic structure biomimetic membrane which is formed by combining various chemical bond crosslinking and electrostatic interaction, and the process conditions are simple, efficient, convenient and environmentally friendly. The biomimetic membrane provided by the invention has a mosaic structure and the characteristics of the raw materials, so that the biomimetic membrane has high ion passing rate, strong ion selection capability, excellent monovalent cation and divalent cation separation capability and certain biodegradability. When the biomimetic membrane is applied to ion separation, the separation capacity of ions with different valence states can be effectively improved, the separation effect of sodium ions and magnesium ions is optimal, and the separation factor is as high as 21.28 and is 54.6 times that of a biomimetic membrane without charges.

The present invention relates to the technical field of mixed matrix membranes, and in particular to a crown ether-loaded UiO-66-NH2 mixed matrix membrane and its preparation method and application. The preparation method comprises: adding glacial acetic acid to a zirconium tetrachloride solution to obtain solution one; adding a crown ether to a 2,5-diaminoterephthalic acid solution to obtain solution two; mixing solution one and solution two and performing a hydrothermal reaction to obtain crown ether-loaded UiO-66-NH2; dispersing a positively charged polymer and crown ether-loaded UiO-66-NH2 in an organic solvent, mixing and forming a liquid film, and obtaining a crown ether-loaded UiO-66-NH2 mixed matrix membrane. The crown ether-loaded UiO-66-NH2 mixed matrix membrane of the present invention has good ion recognition ability, overcomes the defect of low selectivity of traditional polymer membranes; and overcomes the shortcomings of the existing chemical reaction grafting method, such as complex reaction process and high raw material cost, through in-situ coating technology.

A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

The present invention discloses a Pomosomes hollow shell structure and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving a positively charged polymer in an oil phase, and dispersing a polyoxometalate and an inorganic salt in an aqueous phase, wherein the polyoxometalate can form an assembly with the positively charged polymer through electrostatic interaction; the inorganic salt is used to reduce the electrostatic repulsion between polyoxometalates; (2) mixing the oil phase and the aqueous phase and then emulsifying, and standing to obtain an emulsion containing a nanoshell structure. The present invention prepares a stable shell structure by using small-sized nanoparticles as raw materials.

The present invention provides methods for characterizing the composition of polymers. Common to these methods, the subunits of a charged polymer strand are moved by the force of electrophoresis across closely spaced electrodes so as to produce tunneling currents modulated by their passage and indicative of their chemical structure. Comparisons of the electronic signals thus obtained to those of known standards that have undergone similar electrophoresis are made so as to determine the composition of the polymer and the linear sequence of its subunits.The invention described here may be used for: the detection and identification of biological agents that may be pathogenic; the sequencing of small linear RNAs that may be present in cells and those that have been linearized by the methods described herein; and the sequencing of linear genomic DNA, mRNAs, linear non-coding RNAs, and polypeptides.

The utility model relates to a kind of packaging structure of fast-charging polymer lithium ion battery, comprising: battery main body, the upper end of which is equipped with tab;Protection plate, is located in the upper end of the battery main body, the lower end surface of the tab is electrically connected after being bent;Plastic package part, is covered in the outside of the protection plate and tab;And connecting piece, with the upper end surface of the protection plate fixed connection, the connecting piece is bent and extends to the side of the battery main body after extending outwards and passing through the plastic package part, and is connected with the side of the battery main body.The utility model can connect the upper end surface of protection plate with the side of battery main body, form support, guide and disperse the stress on the tab of existing plastic package structure to the side of more stable battery main body, to enhance the overall stability and reliability of plastic package structure.

A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.

In the present invention, positively charged cerium hydroxide particles without undergoing surface charge treatment are subjected to ultrasonic agitation, so that a negatively charged polymer or monomer and the cerium hydroxide particles form a coordination bond, thereby forming a first surface coating layer and reversing the surface charge into a negative charge; and in a second coating step, a weakly positively charged polymer is added, so that by means of charge attraction, a polymeric ion pair is formed, thereby achieving a second charge reversal to a positive charge. Disclosed in the present invention is a method for multiple surface coatings of cerium hydroxide particles. The coated cerium hydroxide particles do not change the intrinsic electrical properties thereof, and can greatly reduce defects caused by mechanical forces during polishing, such as particle adhesion, thereby improving the product yield.

This invention relates to a monovalent selective anion exchange membrane, its preparation method, and its application. The preparation method includes the following steps: placing the anion exchange base membrane in an electrodeposition solution for electrodeposition; the electrodeposition solution includes a negatively charged polymer and a neutral salt; then placing it in an oxidant solution for a chelation reaction; and finally placing it in a polymer monomer solution for polymerization to obtain the monovalent selective anion exchange membrane. This invention, through sequential electrodeposition, chelation, and polymerization reactions, utilizes the active sites formed by the chelation reaction between the negatively charged layer and the oxidant to regulate the directional polymerization of the polymer, forming a dense polymer-modified layer. This avoids polymer clogging of the anion exchange base membrane pores, achieving high ion selectivity, effectively weakening the trade-off effect between flux and selectivity of the monovalent selective anion exchange membrane, and exhibiting good antifouling performance.

A nanopore is provided having a charged polymer attached thereto. At least one end of the charged polymer is fixed at or near one end of the channel of the nanopore in a position that allows the charged polymer to enter the channel. The charged polymer may optionally be fixed in a threaded configuration. When in a threaded configuration, the charged polymer increases the electrical conductivity of the nanopore while still allowing other polymers (such as nucleic acids or polymer tags of tagged nucleotides) to flow through the channel of the nanopore.

A biologic composition for promoting wound healing includes: a human mesenchymal stem cell (MSC)-derived extracellular matrix (ECM) biologic component, and a negatively charged polymer, combined with the biologic component to form the biologic composition. A method of preparing the biologic composition thereof includes: (i) isolating human mesenchymal stem cells (MSC) and subjecting the MSC to hypoxia-priming in a xeno- and / or serum-free, or chemically defined medium to stimulate the production of an MSC-derived biologic component with pro-angiogenic factors; (ii) aggregating and co-precipitating the MSC-derived biologic component with a negatively charged polymer into a pericellular space of the MSC to produce an aggregated biologic component; (iii) assembling the aggregated biologic component and the negatively charged polymer into an insoluble extracellular matrix (ECM) by the MSC; and (iv) decellularizing the insoluble ECM to obtain the biologic composition comprising MicroParticles of Solidified Secretome (MIPSOS).

The invention discloses a negative plate with a directional gradient pore structure, a composite pore-forming agent for preparing the negative plate, a preparation method and a lithium ion battery, the composite pore-forming agent has a core-shell coating structure and a surface functionalization modification layer, the core-shell coating structure comprises an inner core and an outer shell coating the outer surface of the inner core; wherein the inner core is a thermal decomposition type pore-forming material, and the thermal decomposition type pore-forming material can be subjected to thermal decomposition in a temperature range of 80-120 DEG C and release gas; the shell is a thermal dissolution type polymer coating layer, and the surface functionalization modification layer is a charged polymer layer and uniformly coats the outer surface of the shell, so that the composite pore-forming agent is endowed with surface charge characteristics. According to the invention, the composite pore-forming agent combining core-shell coating and surface functional modification is designed and is matched with an electric field-assisted gradient sedimentation and segmented heating pore-forming process, so that directional gradient regulation and control of a pore structure in the thickness direction of the pole piece are realized in a single pore-forming agent system.

The invention provides a high-solid-content preparation method of a cyclic polymer brush and the prepared cyclic polymer brush. The preparation method comprises the following steps: obtaining a polymer brush precursor, wherein the polymer brush precursor has a group A, a group B, a group C and a group D; wherein the group A and the group B exist on the main chain, and the group C and the group D exist on the main chain and / or the side chain; reacting the charged reaction reagent with at least a part of groups C of the polymer brush precursor to convert at least a part of groups C into charged groups to obtain a charged polymer brush precursor; carrying out intramolecular cross-linking reaction on the group D and a dynamic cross-linking agent to obtain nano-particles formed by a cross-linked polymer brush precursor; the group A and the group B of the cross-linked polymer brush precursor are subjected to a ring-closing reaction to form a ring structure, and at least part of side chains exist on the ring structure; and releasing intramolecular crosslinking of the crosslinked polymer brush precursor, and optionally removing the charged groups to obtain the annular polymer brush.

The invention discloses a preparation method of a positive electrode material, and the preparation method comprises the following steps: carrying out polymerization reaction on a polymer monomer to obtain a positively charged doped polymer, and carrying out dedoping and purification treatment to obtain positively charged polymer particles; dispersing the polymer particles in a non-polar solvent to obtain a polymer suspension, and dispersing a negatively charged positive electrode matrix material in a polar solvent to obtain a matrix suspension; and mixing the polymer suspension and the matrix suspension, adsorbing positively charged polymer particles on the surface of a negatively charged positive electrode matrix material through charge interaction, and separating and drying to obtain the positive electrode material of which the surface is coated with the polymer. Through the surface coating, the normal-temperature cycling stability is remarkably improved, reversible overheating protection at high temperature is realized, and the core contradiction between high capacity and insufficient safety of the positive electrode material is effectively solved.

The present invention discloses a temperature-responsive flexible anti-fouling and drag-reducing composite coating, its preparation method and application. The flexible anti-fouling and drag-reducing composite coating comprises a base layer, a flexible buffer layer, an anti-fouling responsive layer and a hydrophobic surface layer formed in sequence on the surface of a substrate; wherein, the base layer comprises an adhesive resin, a positively charged polymer and particulate fillers; the flexible buffer layer comprises a flexible polymer resin, a negatively charged polymer, a polymer drag reducer and an anti-ultraviolet additive; the hydrophobic surface layer comprises a flexible polymer resin, temperature-responsive polymer microcapsules encapsulating anti-fouling agents, pore-forming agents, anti-ultraviolet additives and superhydrophobic micro-nano particles. The temperature-responsive flexible anti-fouling and drag-reducing composite coating provided by the present invention has strong binding force with the substrate, and also has anti-fouling property, corrosion protection performance and drag-reducing performance; at the same time, the preparation method provided by the present invention has the advantages of wide application range and large-area coating.

The application discloses a kind of magnetic microspheres and its preparation method and application in detection, belong to the field of biological detection magnetic material.The present application takes charged polymer microspheres as core, through solvent-thermal method or electrostatic interaction to coat magnetic particle, then through Stober method to coat silicon layer and build charged interface, then composite nano emulsion microspheres on the surface of silicon layer, through high-temperature melting and flattening to form dense and uniform polymer outer layer, finally obtain multilayer sandwich structure magnetic polymer microspheres.The method of the present application simplifies process, and surface interface is easily controlled, and the microspheres prepared have the advantages of uniform particle size, controllable size, adjustable magnetism, high stability, low non-specific adsorption, etc., and are especially suitable for in vitro diagnostic detection field.

This application discloses a method and apparatus for preparing formaldehyde-free decorative paper impregnated with aqueous polyacrylate, belonging to the field of decorative paper production technology. The method includes: providing continuously running formaldehyde-free decorative paper; establishing an asymmetric pulsed electric field within a reactor impregnated with an aqueous polyacrylate emulsion along the path of the formaldehyde-free decorative paper; and controlling the formaldehyde-free decorative paper to pass through the reactor, so that negatively charged polymer micelles in the aqueous polyacrylate emulsion, under the action of the asymmetric pulsed electric field, overcome electrostatic repulsion and surface tension, and are forcibly and rapidly penetrate and fill the internal fiber network of the formaldehyde-free decorative paper. This application fundamentally solves the technical problem of the difficulty in deeply and uniformly impregnating the base paper with environmentally friendly aqueous resin under high-speed production conditions by introducing an electrodynamic forced penetration mechanism.