Method for preparing in-situ therapeutic substance-loaded microcapsules

A therapeutic and microcapsule technology, which is applied in the field of biomedicine and biomaterials, can solve the problem that it is difficult to meet the stable and sustained release of microcapsules, the controllable release and sustained release of drugs are difficult to maintain, and the wall layer of microcapsules collapses. and other issues, to achieve excellent biological safety and controlled drug release, which is conducive to sustained release and adjustable particle size.
CN101721389AInactive Publication Date: 2010-06-09ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2010-06-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing therapeutic substance-loaded microcapsules. The method applies the high-voltage electrostatic spray principle and comprises the steps of leading therapeutic substance-loaded charged polymer solution to instantaneously form ultrafine gel particles under the high-voltage electrostatic action, leading a mist of the particles to be received by polymer solution charged with opposite charges, leading a surface layer of the gel particles to be wrapped by a polymer gel shell layer of the opposite charges, forming structures of capsule cores and capsule walls, further filtering by a microporous membrane, and obtaining the therapeutic substance-loaded microcapsules. Microstructures and scale of the capsule cores and the capsule walls can be precisely controlled through voltage, solution concentration and distance from a jet orifice to receiving solution, and therapeutic substances are bound by the capsule cores and the capsule walls, thereby forming controlled release and improving therapeutic efficacy. The method has the advantages of simple and feasible process and good repeatability, the whole process of the preparation process is clean and pollution-free, the provided in-situ therapeutic substance-loaded microcapsules do not need the complex post-processing, the particle size is controllable, and the release rate of the therapeutic substances is convenient to control, thereby having good application prospect.
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Description

technical field

[0001] The invention relates to a method for preparing microcapsules, in particular to a method for preparing microcapsules loaded with therapeutic substances in situ, and belongs to the technical fields of biomedicine and biomaterials. Background technique

[0002] Microcapsules refer to the use of natural or synthetic polymer materials to wrap dispersed solids, liquids, and even gaseous substances to form tiny particles with semi-permeable or sealed capsules. So far, the effective microencapsulation of active substances such as drugs, proteins, growth factors, vitamins, spices, antibacterial ions, nanoparticles, etc., and even living cells has been used in many fields such as disease treatment and prevention, functional food, cosmetics, industrial separation, etc. etc. are more and more widely used, and become one of the high-tech materials that will be researched and developed in the 21st century.

[0003] At present, the preparation methods of microcapsu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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