26397results about "Pharmaceutical active ingredients" patented technology

The invention provides a lipidosome, a preparation method thereof and application of the lipidosome in preparation of a medicine for treating PARP inhibitor-resistant breast cancer, and relates to the technical field of biology. The preparation method of the liposome provided by the invention comprises the following steps: under a stirring condition, injecting an ethanol solution dissolved with soybean phospholipid and cholesterol into a histidine aqueous solution for hydration, volatilizing an ethanol component after the hydration is finished, and carrying out ultrasonic treatment to prepare the liposome. The preparation method is simple and convenient, and the prepared liposome loaded with histidine is high in encapsulation efficiency. The research of the inventor finds that histidine metabolism reprogramming occurs in the PARPi resistance process of breast cancer cells, so that DNA synthesis repair is maintained. And after the PARPi-resistant breast cancer cells are treated by adopting the liposome disclosed by the invention, the histidine content in the breast cancer cells can be increased, so that the PARPi-resistant cells are sensitive to PARPi, and further the treatment on the PARPi-resistant breast cancer is realized.

A pharmaceutical combination comprising a KRAS inhibitor, a composition comprising same, and a use thereof. The pharmaceutical combination A comprises a substance X and a substance Y, wherein the substance X is a JAK inhibitor or a pharmaceutically acceptable salt thereof; the JAK inhibitor is one or more of fedratinib, ruxolitinib, and baricitinib; the substance Y is a compound comprising a fragment as shown in formula I or a pharmaceutically acceptable salt thereof. The combined use of the KRAS inhibitor and the JAK inhibitor has a synergistic effect, and the application prospect is good.

A pharmaceutical composition comprising a protein arginine methyltransferase 5 (PRMT5) inhibitor and a KRASG12C (Kirsten rat sarcoma viral oncogene homolog glycine-to-cysteine) inhibitor. The pharmaceutical composition can be used for treating various cancers, comprising solid tumors. The combined product can be used for treating any number of diseases associated with PRMT5 and / or KRASG12C.

A process for exfoliating the skin, including the scalp, and / or the nails, comprising the step consisting in subjecting a surface of said skin (K), or said nails, to a cosmetic composition and to ultrasonic acoustic waves emitted by a device comprising at least one ultrasonic transducer (13), with an acoustic intensity Isata in the region exposed to the acoustic waves that is at least equal to 0.1 W / cm2, i) the transducer being moved relative to said surface at an average sweeping speed of between 0.01 cm2 / s and 15 cm2 / s for the duration of treatment of said surface, and / or ii) the device being applied to a location on the keratin material, then moved away from the latter and applied to a different location.

The invention discloses bacillus velezensis as well as fermentation product filtrate and a biological product thereof, and belongs to the technical field of microorganisms, a bacillus velezensis BTN-HB-F4 strain is separated and purified from prinsepia utilis royle in Harba snow mountain in Yunnan province, the fermentation product filtrate of the bacillus velezensis has excellent HAS inhibition capacity and remarkable DPPH and ABTS free radical scavenging capacity, and the biological product of the bacillus velezensis has the advantages that the biological product can be used for preparing biological products of the prinsepia utilis royle; a good anti-oxidation effect can be realized; secondly, under various concentrations, fermentation product filtrate can remarkably reduce the proportion of SA-beta-Gal positive cells, gene expression of matrix metalloproteinase 3 can be remarkably inhibited, and a good anti-aging effect is achieved; in addition, fermentation product filtrate can remarkably inhibit generation of zebra fish melanin and has a good whitening effect; the secretion amount of cell inflammatory factors IL-6 and TNF-alpha can be remarkably inhibited, and a good relieving effect is achieved; finally, the fermentation product filtrate can effectively inhibit the growth of pathogenic bacteria staphylococcus aureus, and has the potential of regulating the skin micro-ecology.

The invention relates to a preparation method of a camellia fermentation product, which is characterized in that camellia is fermented by adopting a mode of firstly performing enzymolysis and then performing fermentation, in the fermentation step, a composite yeast strain fermentation mode is adopted, the camellia is fermented through the synergistic effect of two yeasts, and the obtained camellia fermentation product is rich in various active substances. Therefore, the fermented product has good comprehensive effects of repairing, relieving and controlling oil.

The invention discloses a ginsenoside Rg3 nano-liposome easier for transdermal absorption as well as a preparation method and application thereof, and belongs to the technical field of liposome preparation. The ginsenoside Rg3 nano-liposome easier to transdermally absorb, provided by the invention, is prepared from the following raw materials in parts by mass: 5 to 20 parts of polyhydric alcohol, 2 to 10 parts of ginsenoside Rg3, 1 to 8 parts of phospholipid, 1 to 5 parts of cholesterol, 1 to 2 parts of resveratrol, 0 to 2 parts of a compound functional substance and 1 to 5 parts of water. The ginsenoside Rg3 nano-liposome easier to transdermally absorb, provided by the invention, has excellent anti-oxidation and anti-inflammatory characteristics through a compound synergistic effect of all the components, can regulate the skin state, comprehensively protect the skin from being damaged by free radicals and inflammation, solves the skin problem caused by external stimulation, and has a good application prospect. The skin care composition has the effects of protecting skin, maintaining skin barrier function, improving skin redness and improving skin stability, can be compounded with any skin care preparation for use, and has wide market application prospect.

The invention discloses a composition for preventing hair loss, controlling oil and removing dandruff and a preparation method thereof, and particularly belongs to the field of preparations for dressing and makeup. The composition for preventing hair loss, controlling oil and removing dandruff comprises the following components: 2-5 parts of a folium artemisiae argyi extract, 1.1-1.6 parts of a ginger root extract, 5-10 parts of a polygonum multiflorum extract and 4-6 parts of a cacumen biotae extract. The polygonum multiflorum extract prepared by the method disclosed by the invention has better bacteriostatic activity, and compared with single strain fermentation, the mixed strain fermentation can more effectively enrich active ingredients in polygonum multiflorum; the anti-hair-loss, oil-controlling and anti-dandruff composition provided by the invention has excellent oil-controlling and oil-inhibiting effects; the shampoo provided by the invention has remarkable effects of preventing hair loss and strengthening hair.

The invention discloses a scalp essence capable of controlling oil and removing dandruff and a preparation method thereof, and provides the scalp essence capable of controlling oil and removing dandruff. The formula consists of the following raw materials: water, saccharomycetes / rice fermentation product filtrate, butanediol, phenoxyethanol, caprylic acid / capric triglyceride, galactose yeast-like bacterium fermentation product filtrate, allantoin, a saccharomycetes / zinc fermentation product, nicotinamide, arginine, polysorbate-20, hydrogenated lecithin, acrylic acid (ester) / C10-30 and an alkanol acrylate cross-linked polymer. Hydrolyzed sodium hyaluronate and trace components. According to the oil-controlling and dandruff-removing scalp essence disclosed by the invention, through the synergistic interaction among the raw materials, the effects of replenishing water, preserving moisture, controlling oil and removing dandruff are increased, the effects of relieving, recovering oil-water balance, recovering skin elasticity and delaying senescence are also achieved, the effects of preventing hair loss and nourishing hair are also achieved, and meanwhile, the oil-controlling and dandruff-removing scalp essence has the advantage of being stable in storage.

The invention discloses an anti-allergy soothing composition as well as a preparation method and cosmetics thereof. The anti-allergy soothing composition comprises the following components in percentage by mass: 2%-8% of a cactus extract, 1%-5% of a radix scutellariae root extract, 0.5%-3% of a Chinese herbaceous peony root extract, 2%-5% of a radix ophiopogonis root extract, 2%-5% of an oat bran extract, 40%-50% of butanediol and the balance of water. The composition has good anti-allergy and soothing effects, when the composition is applied to skin care products and cosmetics, the cosmetics can have the good anti-allergy and soothing effects, and the skin care products and the cosmetics can have good universality. Meanwhile, the preparation method of the anti-allergy soothing composition is simple and easy to implement and easy to popularize and use.

The invention provides a male skincare composition as well as a preparation method and application thereof. The skincare composition comprises salicylic acid, a skin conditioner, polyhydric alcohol, a centella asiatica extract and water, the skin conditioner includes a combination of lactobionic acid, succinic acid, inositol hexaphosphate, mandelic acid, and tetrahydromethylpyrimidine carboxylic acid. According to the composition, salicylic acid, the skin conditioner, the centella asiatica extract and polyhydric alcohol are used in cooperation, skin barrier damage caused by excessive cleaning can be avoided, the skin barrier protection function of the product is remarkably enhanced, the product has the excellent effects of regulating sebum secretion and maintaining skin water-oil balance, and the skin care effect is good. And the acne and coarse pore problems can be improved in a multi-dimensional manner for men with acne skin, and sebum secretion is regulated to prevent acne recurrence.

The invention belongs to the technical field of preparation of microorganisms and cosmetics, and particularly relates to a strain composition, radix paeoniae rubra fermentation liquor prepared from the strain composition and application of the strain composition in cosmetics. Specifically, Pseudoalteromonas sp. SE9 and Schizoscharomyces pombe JM2-16 are utilized to perform fermentation treatment on radix paeoniae rubra root powder, and the finally obtained radix paeoniae rubra fermentation liquor has multiple effects of resisting oxidation, promoting proliferation and migration of keratinocytes, promoting skin injury repair, resisting allergy, resisting inflammation, relieving and the like, is high in safety, can be used as a cosmetic component, and can be used as a cosmetic preparation. Therefore, the method has good practical application value.

The invention provides a repairing and anti-aging composition specially researched for dry sensitive skin and application of the repairing and anti-aging composition, and belongs to the technical field of cosmetics. According to the anti-aging composition disclosed by the invention, inositol, ceramide-NP, phytosphingosine, a golden camellia extract, a waxberry bark extract and a fructus cnidii extract are selected according to a specific mass ratio, and the six components are combined for use, so that a strong anti-aging network can be formed, and a plurality of aspects act together, so that the anti-aging composition has a good anti-aging effect. The permeation promoting, repairing, moisturizing, anti-aging and soothing effects of the anti-aging composition are improved.

The invention belongs to the field of pet deodorization, and particularly relates to pet shower balm containing natural deodorization extracts and lasting in fragrance and a preparation method of the pet shower balm. The shower balm for pets comprises the following raw materials: a persimmon extract, silica, an emulsifier, an antioxidant, a hard water ion chelating agent, a thickening agent and a solubilizer. The preparation method comprises the following steps: mixing the persimmon extract and the silica to obtain a solution A; mixing coconut oil, olive fruit oil and glycerol to obtain a solution B; adding sodium polyacrylate and microcrystalline cellulose into water, and dissolving; adding a hard water ion chelating agent, and mixing to obtain a mixed solution; and finally, adding the mixed solution into the solution A and the solution B, mixing, cooling, adding the antioxidant, and stirring. The persimmon extract and the silica have a very good removal promoting effect, and have a good application prospect.

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

A subject of the present invention is a cosmetic composition comprising 6-hydroxybenzomorpholine of formula (II), hydroxyethyl-3,4-methylenedioxyaniline of formula (III) and oxidation bases. The present invention also relates to a process for dyeing keratin fibres, such as the hair, wherein the composition as described previously is applied to said fibres. Another subject of the present invention is the use of the composition according to the invention for the cosmetic treatment of keratin fibres such as the hair.

The invention relates to the technical field of freeze-dried preparations, and provides exosome freeze-dried powder as well as a preparation method and application thereof. The exosome freeze-drying preparation is prepared by mixing an exosome solution and a freeze-drying protection solution and then freeze-drying the mixture, the concentration of the exosome solution in the mixed solution is 0.1-10% V / V, and the freeze-drying protection solution comprises 0.4-4% W / V of saccharides and 0.25-4% W / V of alcohols; the saccharide is trehalose, cane sugar or lactose; the alcohol is mannitol, sorbitol or a combination of mannitol and polyethylene glycol; and the solvent is sterilized water for injection or a PBS buffer solution. The exosome freeze-dried powder is stable in activity, small in irritation, good in safety and good in fibroblast proliferation promoting capacity, when the exosome freeze-dried powder is applied to supporting essence or masks in the medical beauty industry, the exosome activity of the exosome freeze-dried powder is still kept stable, and the application prospect is good.

The invention relates to a preparation method of a chlorella exosome as well as a product and application of the chlorella exosome, the preparation method comprises the following steps: (1) mixing extremely micro chlorella with a separation buffer solution, and then carrying out wall breaking treatment to obtain a cell breaking solution; (2) centrifuging the cell disruption liquid, and reserving supernate; and (3) filtering the supernate to obtain the chlorella exosome. The preparation method of the chlorella exosome, provided by the invention, is simple in steps and easy to operate, the chlorella raw material and the specific separation buffer solution are subjected to wall breaking treatment, so that active ingredients in the prepared chlorella can be better extracted, the content of protein and polysaccharide in the obtained exosome is higher, and the purity of the exosome is improved. Meanwhile, gradient centrifugation, filter membrane filtration and the like are assisted in the preparation process, so that the prepared exosome is high in purity and less in impurities.

The invention provides a preparation method of lipidosome containing hair-growing active ingredients, and belongs to the technical field of hair-growing products. According to the invention, active substances are utilized to regulate hormone level, improve scalp blood circulation, stimulate anti-hair loss factors and promote hair growth in multiple directions, and lipidosome formed by lecithin and oil-soluble active ingredients as raw materials is utilized to integrally entrap the active substances, so that the anti-hair loss effect is improved. The defect of weak transdermal ability caused by large water solubility difference among the active substances is overcome, the stability and bioavailability of the active substances can be improved, and the hair growth and development effects of the prepared lipidosome containing the hair growth active components are remarkably improved.

The present invention belongs to the technical field of cosmetic raw materials, and specifically relates to a kind of oxidized hyaluronic acid-PDRN-peptide nanoemulsion and its preparation method. The nanoemulsion comprises oxidized hyaluronic acid, PDRN and polypeptide, and the nanoemulsion is formed by oxidized hyaluronic acid, PDRN and polypeptide through layer-by-layer self-assembly technology. Specifically: positively charged polypeptide is used to wrap negatively charged PDRN to form positively charged composite particles, or negatively charged PDRN is used to wrap positively charged polypeptide to form electrostatic composite particles, and then, the positively charged composite particles or the electrostatic composite particles are further wrapped with oxidized hyaluronic acid as a packaging material, and finally oxidized hyaluronic acid-PDRN-peptide nanoemulsion is formed. The nanoemulsion of the present invention can improve the stability of polypeptides, improve the problems that polypeptide molecules are difficult to penetrate the skin and have low bioavailability, and effectively improve the transdermal rate and stability of PDRN, give play to the tissue repair function of PDRN, further amplify the anti-inflammatory effects of the two, and improve the bioavailability of active ingredients.

The invention discloses hip cream as well as a preparation method and application thereof, and belongs to the technical field of infant care products. The hip cream comprises a phase A, a phase B and a phase C, wherein the phase A comprises caprylic capric triglyceride, olive oil, camellia-seed oil, cera alba, sunflower seed oil and white ozocerite; a phase B: trihydroxy stearin; a phase C: VE acetate, folium artemisiae argyi essential oil, Roman chamomile, tea tree oil and double purple oil; and phase D: simmondsia chinensis seed oil. According to the invention, by optimizing the components and dosage in the hip cream, the prepared hip cream has good anti-inflammatory, soothing, moisturizing and skin repairing effects, the problems of red buttocks of newborns and skin ulceration, water loss, chapping, desquamation and the like caused by the red buttocks of the newborns are reduced, and meanwhile, the use of medicaments such as erythromycin ointment and the like is reduced. Meanwhile, the surface of the paper diaper can be coated with the hip cream to obtain the paper diaper containing the hip cream coating, the repairing and other effects of the hip cream are utilized, meanwhile, the paper diaper containing the hip cream has better soft feeling and smooth feeling, and damage caused by friction of the paper diaper is reduced.

The invention discloses a permeation promoting composition and application thereof in skin care products, and particularly belongs to the field of cosmetics. The permeation enhancing composition is prepared by compounding hydroxyethyl chitosan and decapeptide-4, and the permeation enhancing composition is prepared by compounding the hydroxyethyl chitosan and the decapeptide-4; the penetration enhancing composition provided by the invention can improve the transdermal absorption rate of the target functional component, so that the target functional component can effectively act on deep skin, and the effective utilization rate of the functional component is improved; the permeation enhancing composition can be applied to skin care products with the effects of tightening, wrinkle resisting, moisturizing, repairing, oil controlling and relieving, and the requirements of consumers for efficient and safe skin care products are met.

The presently claimed invention is directed to a bleaching medium comprising at least one phenalenone which is capable of generating singlet oxygen, at least one persulfate salt, at least one alkalizing agent and at least one hydrogen peroxide source and methods for bleaching hair by using the bleaching medium.

According to some embodiments, a method of promoting hair growth or hair stimulation in a subject comprises applying vacuum or suction using a handpiece assembly along a targeted portion of the subject's skin surface where hair growth or hair stimulation is desired and providing at least one treatment material to said targeted portion of the subject's skin surface, wherein the application of vacuum or suction helps promote hair growth or stimulate hair.

The invention discloses an anti-aging composition containing ergothioneine, glutathione and fish collagen, relates to the technical field of anti-aging compositions, and aims to solve the technical problems that a traditional anti-aging composition lacks attention to the aspects of cell energy metabolism, barrier repair and the like, and the overall skin improvement effect is not obvious. The ergothioneine is used as a natural antioxidant, and the content of the ergothioneine is 0.01-5wt%; the ergothioneine participates in a synergistic effect of an intracellular antioxidant enzyme system, so that tyrosinase activity is effectively inhibited, melanogenesis is reduced, and DNA and protein are protected from oxidation damage; in a simulated strong ultraviolet environment, compared with skin cells not using the ergothioneine-containing product, the content of free radicals in the cells is reduced by 30% after the ergothioneine-containing product is used; the ergothioneine can also regulate a cell signal channel, promote cell metabolism and maintain normal growth of cells. The mask has the advantages of accelerating skin metabolism and improving the self-repairing ability of the skin.

The invention discloses a high-biocompatibility pH response type Pickering emulsion and a preparation method thereof, and relates to the technical field of food and materials. An interfacial film with high mechanical strength is constructed by adopting electrostatic interaction and hydrophilic-hydrophobic complementary characteristics between the hydrophobic shellac nanoparticles carrying negative charges and the hydrophilic cationic colloidal particles carrying positive charges, and the prepared emulsion has good viscoelasticity and stability. In addition, due to the unique solubility of the shellac nanoparticles, the Pickering emulsion prepared by the preparation method disclosed by the invention has excellent pH responsiveness. The preparation method of the Pickering emulsion is convenient and simple, the stabilizer is wide in source and low in price, the biocompatibility of the emulsion is high, and the Pickering emulsion has wide application prospects in the aspects of food, medicine, materials and the like.

The invention provides a process for preparing various nutritional ingredients from oats, and relates to the technical field of deep processing of oats. The process comprises the following steps: crushing and sieving oats to obtain oat bran; the method comprises the following steps: extracting oat bran through a supercritical extraction technology to obtain pretreated oat bran and an extract, and carrying out gradient membrane treatment and membrane ultrafiltration on the extract to obtain oat oil; extracting the pretreated oat bran through continuous sectional extraction equipment; after first-stage protein extraction, second-stage dextran extraction, third-stage immobilized enzymolysis and fourth-stage filler decoloration, the materials enter a system balance tank, and membrane separation and concentration are performed to obtain the oat beta-dextran. According to the invention, various nutrient substances such as oat beta-glucan, oat protein, oat oil and the like can be extracted at the same time, the defects in the prior art are overcome, the automation degree is high, and energy conservation and emission reduction are realized.

The invention provides a method for preparing multi-dimensional co-assembled hydroponic oil and application of the multi-dimensional co-assembled hydroponic oil, and belongs to the technical field of grease fermentation. The method comprises the following steps: S1, taking an oil-insoluble substance, mixing the oil-insoluble substance with soybean phospholipid in absolute ethyl alcohol, stirring at 50-70 DEG C until the solution is clear, centrifuging, taking a supernatant, and volatilizing a solvent to obtain a compound; s2, dissolving chitosan and fermentation oil in an acetic acid solution with the concentration of 0.5-2 wt%, uniformly mixing, and standing to obtain a mixed solution; s3, dissolving the compound obtained in the step S1 in absolute ethyl alcohol, slowly dropwise adding into the mixed solution obtained in the step S2 in a constant-speed stirring state, and stirring until the mixed solution emits micro-blue opalescence to obtain a co-assembled solution; and S4, adding the co-assembled solution in the S3 into grease to obtain the multi-dimensional co-assembled hydroponic oil. According to the method, oil-insoluble components can be wrapped and dissolved in grease, the structure is stable, the skin permeation and absorption performance of effective components can be improved, and the grease is endowed with more dermatological functional activity.

A multidrug linker, an antibody-drug conjugate comprising the multidrug linker, a preparation method for the antibody-drug conjugate, and uses of the multidrug linker and the antibody-drug conjugate in disease treatment. A specific structure can effectively reduce the aggregation of a multi-payload drug-antibody conjugate, thereby facilitating process scale-up. In addition, payload drugs can achieve a significant synergistic effect, thereby achieving a synergistic anti-tumor effect, effectively overcoming the resistance to drugs, and improving the therapeutic window of drugs.

The invention provides application of UBR5 in preparation of drugs for treating pigmented skin diseases, and further the pigmented skin diseases comprise various types of pigmented nevus (mainly congenital pigmented nevus and megalous with the risk of malignant transformation). Various pigmented spots (mainly chloasma, freckles, Taitian nevus, post-inflammation hyperpigmentation and the like) and hypopigmentation / depigmentation spots (mainly leucoderma, post-inflammation hypopigmentation and the like). Experimental results show that UBR5 is highly expressed in disease tissues such as pigmented nevus. The UBR5 expression level and the melanogenesis ability are in significant positive correlation, targeted knockout / knockdown of UBR5 in melanocytes can significantly inhibit the expression level of melanogenesis related genes such as MITF, TRP1, TRP2, TYR and other proteins, the melanin content of melanocytes and tyrosinase activity, vice versa, and the melanogenesis ability of melanocytes after overexpression of UBR5 is significantly increased.