88 results about "Process scale" patented technology

The current landscape for preparative chromatographic RNA purification uses reversed phase HPLC, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short RNAs. The invention provides preparative purification of RNA (e.g., mRNA) using ion (e.g., anion) exchange chromatography that allows for separation of longer RNAs up to 10,000 nucleotides in length via a scalable method. This method avoids problems with current techniques by using low pressure chromatography that is agreeable with existing equipment in cGMP commercial facilities, that uses aqueous-bases solutions as the mobile phase (rather than flammable of greater than 10 mg RNA / mL resin (e.g., using larger pore sorbents, >500 Angstroms, that display greater mRNA binding capacities), and that yields desired RNA salt forms for downstream formulation with no additional manipulation necessary (unlike ion pair reverse phase techniques).

The present invention provides apparatus, kits and methods for evaluating binding between one or more binding molecules (e.g., a protein) and one or more ligands. The invention also provides apparatus, kits and methods for detecting and / or quantifying a binding molecule, for example, a protein. Also provided are apparatus, kits and methods for “stripping” a complex biological matrix of low molecular weight components. The invention can be carried out on a smaller process scale, and therefore be more efficient, than previously known methods. The present invention is particularly suitable for use in high-throughput assays, which can be partially or completely automated.

The invention relates to a production process for vinegar, in particular to the standardized and industrialized production process for Shanxi mature vinegar, which solves the problems of long production process period, complex process, unstable product quality, low raw material utilization rate and the like, of the prior production process. The production process comprises the following steps of: performing material processing before alcoholic fermentation, crushing, mixing, liquefaction and saccharification; selecting high-temperature resistant and high-alcoholic strength resistant saccharomyces, and adding a composite yeast to perform alcoholic fermentation; adding the composite acetic bacteria into vinegar residue, stirring with a vinegar residue stirrer, fermenting the vinegar residue in an acetyl hydrate fermenting tank, and turning the vinegar residue with a vinegar residue turning machine; tamping the vinegar residue in the acetyl hydrate fermenting tank, covering a layer of table salt on the tamped vinegar residue, and standing the vinegar residue; fuming the vinegar residue by the combination of a vinegar residue fuming furnace and a steam vinegar residue fuming jar; pouring vinegar; ageing the vinegar; clarifying the vinegar with a crude acidic protease, and filtering the vinegar with kieselguhr; blending the vinegar and the traditional Shanxi mature vinegar; sterilizing the vinegar; and packing the vinegar. The process of the invention has the advantages of systematized flow, standardized technological parameters, scale production procedure, normalized product quality and optimized production process.

The electric Fenton oxidation process for processing scale inhibitor in reverse osmosis concentrated liquid adopts anode of iron plate and cathode of porous graphite and ventilated with air pump and processes reverse osmosis concentrated liquid through electrolyzing in stirring, stirring coagulation via adding aluminum sulfate and filtering the coagulated solution. Bivalent iron ion produced intelligent the electric Fenton process is made to react with hydrogen peroxide to produce strong oxidizing free hydroxy radical oxidizing and destructing the scale inhibitor; and the subsequent coagulation separates out scaling salt to lower the scaling trend, so that the concentrated liquid may be utilized as influent water to raise the water recovering rate of reverse osmosis system.

The invention relates to a graphene-reinforced nickel-based composite coating material and a laser cladding technology thereof, belonging to the technical field of surface modification of materials. The graphene-reinforced nickel-based composite coating material is characterized in that a nickel-based self-fusing alloy is taken as a matrix material of a cladding layer, graphene in the percentage by volume of 0.5-20% is taken as a reinforcing phase, and then a composite coating with excellent wear resistance and anti-friction performance can be prepared on a steel and alloy matrix by utilizing the laser cladding technology. The graphene-reinforced nickel-based composite coating material disclosed by the invention has the advantages that the variation range of the content of the graphene is wide, and the coating has uniform and dense structure, excellent wear resistance and anti-friction performance and good metallurgical bonding with the matrix, and can meet the requirements of carbon steel and alloy steel members for friction and wear performance under different working conditions; and furthermore, the scale and the degree of automation of the preparation process of the coating are high, and the graphene-reinforced nickel-based composite coating material can be widely applied to aerospace, machinery, automobiles, military industry and other fields.

The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.

The present invention belongs to electronic reading application field, in particular relating to an electronic reading processing method and system fit for screen resolving capability. The present electronic reading adopts dynamic layout technology to adjust layout size, or adopting fixed layout size; the former can not achieve original edition recurrence because of need re-layout, when re-layout, need mass calculations lead lower efficiency; the back can achieve original edition display effect, having high display efficiency, since the size of the layout is fixed, it is presented by the fixed size in the fixed place of the user screen. The method and system of the invention processes scale of the electronic reading by comparing the screen resolving capability and the electronic reading resolving capability, capable of selecting proper reading style according to the needs. The method and system of the invention make the electronic reading having different size display in the screen having different screen resolving capability, making overall plans to the reading needs of all kinds of users.

A method for manufacturing a phase change memory device comprises forming an electrode layer. Electrodes are made in the electrode layer using conductor fill techniques that are also used inter-layer conductors for metallization layers, in order to improve process scaling with shrinking critical dimensions for metallization layers. The electrode layer is made by forming a multi-layer dielectric layer on a substrate, etching the multi-layer dielectric layer to form vias for electrode members contacting circuitry below, forming insulating spacers on the vias, etching through a top layer in the multi-layer dielectric layer to form trenches between the insulating spacers for electrode members contacting circuitry above, filling the vias and trenches with a conductive material using the metallization process. Thin film bridges of memory material are formed over the electrode layer.

A composite filter medium comprising a filter element comprising at least one porous fibrous filtration layer, and at least one layer of a sorbent, stationary phase particulates selected from organic or inorganic particulates having an average diameter of less than 50 micrometers, soft particulates, and ground monolithic particulates. The particulates are capable of binding target molecule by, for example, adsorption, ion exchange, hydrophobic binding, and affinity binding. The particulates provide higher binding capacities than can be achieved using filter media incorporating conventional process scale chromatography resin particulates.

The invention provides a novel crystal form of roxadustat and a preparation method of the novel crystal form. The crystal form ARZ-A has better stability and solubility than existing crystal forms. The preparation process of the crystal form is simple and feasible, a used solvent has low toxicity, stability of the crystal form is good, and the crystal form is more suitable for process scale-up production.

The invention relates to production equipment for steam explosion treatment of micropore structure substances, and the equipment is key treatment equipment of biomass utilization, biochemical engineering, fermentation brewing, solid waste treatment and other industries. The invention provides an instantaneous ejection type steam explosion machine utilizing the steam ejection principle to complete the steam explosion process. Opening of an explosion channel of the steam explosion machine utilizes the steam ejection pressure generated by section difference, thus overcoming the problem of prolonged deflation time along with treatment volume increase in traditional hot blow process. With the increase of the cylinder volume, the section difference also increases accordingly, so that the cylinder ejection velocity can maintain consistent, thus laying the foundation for process scale-up.

The invention provides a composite steel pipe which is wound with a plastic tape on the outer wall and sprayed and coated with plastics on the inner wall; the outer wall of the composite steel pipe is provided with a plastic tape winding layer, and the inner wall thereof is provided with a plastic coating layer. A processing method comprises: A. the steel pipe is placed on a roller wheel bracket to rotate, and the inner and the outer walls of the steel pipe are cleaned by spraying sand; B. the steel pipe is placed on the roller wheel bracket to rotate and preheated to 160-180 DEG C; C. the steel pipe is placed on the roller wheel bracket to rotate and is thermally wound with the plastic tape winding layer of 3-5mm at the outer wall; D. the steel pipe is placed on the roller wheel bracket to rotate and is sprayed and coated with the plastic coating layer on the inner wall by utilizing the excess heat of the steel pipe. The invention can form commercial process scale only by using the existing plastic tape extrusion equipment as well as adding two roller wheel brackets and a set of spraying equipment, and can produce any clad pipe having the diameter within the range of 300mm-3000mm. As the outer wall of the steel pipe is wound with PE material which is hard wearing and shockproof, and the inner wall is sprayed with polyurea material that is environment-friendly and has stable performance, the composite steel pipe has good antiseptic property, and the outer wall has very high damage resistance, thus being safe and environment-friendly and greatly improving the production efficiency and the combination property.

A semiconductor memory device for reliably inducing a breakdown in the dielectric when utilizing an antifuse to write on the dielectric film even when the process scale has become more detailed. The semiconductor memory device includes an antifuse serving as the memory node, and a current regulator connected in serial with the antifuse. The current controller is comprised of a P-type semiconductor substrate and a reverse-conduction N-type well, a diode coupled to a P+ diffusion substrate of the same conducing type as the P-type semiconductor substrate. The antifuse contains at least a structure where an electrode is formed via a dielectric film on the reverse-conducting N+ diffusion layer and the P-type semiconductor substrate. The N+ diffusion layer is connected to the N-type well of diode, and the diode regulates the current.

The invention relates to a mixed diamine monomer adopted chlorine-resistant nanofiltration membrane and a preparation method therefor. An aqueous-phase monomer is prepared through mixing 2,2'-di(1-hydroxyl-1-trifluoromethyl-2,2,2-trifluoroethyl)-4,4'-methylene dianiline with piperazine. The preparation method comprises the following steps: (1) adjusting the temperature and humidity of an experimental environment; (2) carrying out basement membrane pretreatment; (3) preparing an aqueous-phase mixed monomer solution and an organic-phase solution; (4) carrying out an interface polymerization reaction; (5) carrying out heat treatment; (6) preparing an active chlorine solution; and (7) integrally submerging the prepared nanofiltration membrane into the active chlorine solution for oxidation treatment, thereby obtaining the final mixed diamine monomer adopted chlorine-resistant nanofiltration membrane. The mixed diamine monomer adopted chlorine-resistant nanofiltration membrane and the preparation method therefor have the advantages that the process is simple, process scale-up is facilitated, and the range of choice of basement membranes is enlarged, so that the industrial actual application value is remarkable.

A solid hollow fiber cooling crystallizer and method for crystallizing aqueous and organic solutions are provided. The solid hollow fiber crystallizer (SHFC) for carrying out cooling crystallization of inorganic / organic microsolutes / macrosolutes from solution generally includes a bundle of non-porous hollow fibers mounted within a shell where a feed solution for crystallization flows through the lumen side of the hollow fibers and a cooling solution flows through the shell side to form nuclei and subsequently crystals in the feed solution at a temperature below its saturation temperature. The solid hollow fiber crystallizer may be combined with a mixing device, such as a completely stirred tank or static mixer, to further effectuate crystallization. The solid hollow fiber crystallizer may be operated in a number of modes including feed recycle mode, once through mode, SHFC-in-line static mixer in series mode, and SHFC-CST in series mode. The advantages of solid hollow fiber cooling crystallization in comparison to conventional crystallization processes include improved temperature control between crystallizing solution and coolant, higher nucleation rates, improved control of crystal size and crystal size distribution, smaller crystal size, capability for decoupling crystal nucleation and crystal growth, decreased fouling of process equipment, and improved process scale-up.

The invention provides a purifying method of sugammadex sodium. The purifying method specially comprises the following steps: putting a sugammadex sodium crude product to a chromatography column usingsilica gel C18 as a filling, and performing purifying, wherein the purity of the obtained sugammadex sodium is greater than 99%. Through adoption of the purifying method disclosed by the invention, the quality of the products can be guaranteed, and the purifying method is suitable for process scaled production.

The invention discloses a nanocarbon clad titanium carbide enhanced nickel-based composite coating material and a laser cladding process thereof, belonging to the technical field of material surface modification. The nanocarbon clad titanium carbide enhanced nickel-based composite coating material is prepared from Ni65.83 Cr15B3.0Si3.5C0.7Fe12 nickel-based self-fluxing alloy powder as a matrix material and nanocarbon clad titanium carbide of 0.5-20vol.% as a wild phase on a steel and alloy matrix by using a laser cladding technology. The nanocarbon clad titanium carbide enhanced nickel-based composite coating material has the advantages of uniform and compact coating structure, good flexibility and excellent corrosion resistance and wear resistance, has better metallurgical bonding with the matrix, can meet the requirements of carbon steel and alloy steel members for friction wear resistance under different working conditions, is large in scale and high in automation degree in a coating preparation process, and can be widely applied to fields such as aerospace, machinery, automobiles, war industry and the like.

The invention discloses a method for mass production of pseudorabies virus vaccine, comprising the following steps: (a) adding netty polyester fiber which serves as a carrier into a bioreactor provided with a tide type micro-carrier suspension culture system and inoculating cells for producing vaccine; (b) inoculating pseudorabies virus vaccine when the culture cell grows to a certain intensity, so that the cells are infected by the pseudorabies virus vaccine; (c) reproducing the virus in great numbers under appropriate conditions; (d) harvesting the virus when cytopathic rate reaches above 70%; (e) carrying out freeze thawing on the harvested virus for once or twice to lead the cells to completely come off and disperse and then adding freeze-drying protective agent, evenly mixing the mixture, packaging the mixture in fixed volume and freeze-drying.The method of the invention has the advantages of good stability, explicit process control indicators, good controllability, easy operation, large process scale and the like.

The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption / ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption / ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.

Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.

There is provided a displacement measuring apparatus efficiently productive and easily applicable to high precise measurement of displacement with contact probe detection for hardly-measurable works in the art such as micro-works and deep parts in complicated structures. A scale member includes a spindle and a scale both supported by a parallel leaf spring movable on a scale substrate. The spindle is arranged in coaxial with a measurement axis in the scale member. The L & S slit-processed scale is integrated with the spindle and supported by the parallel leaf spring to move together with the spindle along the measurement axis. The spindle, scale and parallel leaf spring are coupled to the scale substrate interposing an anchor of the parallel leaf spring therebetween. The spindle, scale and parallel leaf spring are formed in an integral structure and only the anchor contacts the scale substrate while the spindle, scale and parallel leaf spring slightly float from the scale substrate. A displacement sensor comprises a sensor substrate arranged opposite to the scale substrate. A light source and a photosensitive device are located on the sensor substrate.

Belonging to the field of pharmaceutical preparations, the invention in particular relates to a method for improving the dissolution rate of an ezetimibe tablet. The method uses ordinary air jet comminution to acquire bulk drugs, and employs ethanol of appropriate concentration to replace purified water for granulation, thus obtaining a product with a dissolution behavior consistent with ezetimibe tablet. The preparation technology has lowered requirement for bulk drugs, can acquire bulk drugs meeting the preparation requirements only by means of ordinary air jet comminution, is easy for process scale-up, and guarantees smooth preparation production.

A solid hollow fiber cooling crystallizer and method for crystallizing aqueous and organic solutions are provided. The solid hollow fiber crystallizer (SHFC) for carrying out cooling crystallization of inorganic / organic microsolutes / macrosolutes from solution generally includes a bundle of non-porous hollow fibers mounted within a shell where a feed solution for crystallization flows through the lumen side of the hollow fibers and a cooling solution flows through the shell side to form nuclei and subsequently crystals in the feed solution at a temperature below its saturation temperature. The solid hollow fiber crystallizer may be combined with a mixing device, such as a completely stirred tank or static mixer, to further effectuate crystallization. The solid hollow fiber crystallizer may be operated in a number of modes including feed recycle mode, once through mode, SHFC-in-line static mixer in series mode, and SHFC-CST in series mode. The advantages of solid hollow fiber cooling crystallization in comparison to conventional crystallization processes include improved temperature control between crystallizing solution and coolant, higher nucleation rates, improved control of crystal size and crystal size distribution, smaller crystal size, capability for decoupling crystal nucleation and crystal growth, decreased fouling of process equipment, and improved process scale-up.

The invention discloses a recovering and separation method for iodine in cephalosporin medicine waste liquid. The method comprises the following steps that alkali is added into the cephalosporin medicine waste liquid, methyl alcohol, acetone and alkali liquid are extracted and separated, the alkali liquid is circularly heated and hydrolyzed, and after filtering, the alkali liquid is conveyed intoan acidizing groove for acidification; organic matter which cannot be dissolved in water is removed through standing and layering, then a water-phase oxidation reaction tower oxidizes I- into IO3-, the alkali liquid is introduced in a reduction kettle, and the IO3- is reduced into I2; simple substance iodine is separated out, after filtering and recovering, crude iodine is obtained, and heating, sublimation and condensation continue to obtain the simple substance iodine. According to the method, precious metal iodine in the waste liquid is recovered, through alkali addition for hydrolyzing andacidizing, iodine exists in the waste liquid in a free state, and the organic matter which cannot be dissolved in water is separated out. According to the method, it is not necessary to strictly control the dosage of an oxidizing agent, the operation is simple and safe, the rate of recovering iodine reaches 98.5% or above, and the method is suitable for process scale-up production.

A method and apparatus for scaling an embedded DRAM array from a first process to a second process, wherein the scaling involves reducing the linear dimensions of features by a constant scale factor. From the first process to the second process, DRAM cell capacitor layout area is reduced by the square of the scale factor, while cell capacitance is reduced by the scale factor. The voltage used to supply the logic transistors is scaled down from the first process to the second process. However, the voltage used to supply the sense amplifiers remains constant in both processes. Thus, in an embedded DRAM array of the second process, sense amplifiers are supplied by a greater voltage than the logic transistors. This allows the sensing voltage of DRAM cells to be maintained from one process generation to another, while allowing memory size to scale with the square of the process scale factor.

The invention relates to a process quality homogenization level evaluation method and system based on a Birch clustering algorithm. The process quality homogenization level evaluation method comprisesthe following steps: collecting key parameter data of tobacco primary processing; extracting historical batch data in the production process; preprocessing the data, and solving a characteristic value of the dimension of the batch by utilizing a Birch clustering algorithm and a Kmeans algorithm; determining dynamic quality stability characterization of steady-state and non-steady-state processes;constructing a quality stability evaluation model from the minimum research unit-process parameter scale to the process scale and then to the batch scale step by step, so as to provide a systematic and effective method for analyzing and evaluating the cut tobacco processing quality from different scales. The clustered data sets record characteristic parameters and time labels of the data, normaldata sets and outlier data sets are distinguished according to the characteristic parameters of the data sets and treated differently in a targeted mode, then the abnormal time periods of the data aretraced according to the time labels of the data, and prerequisite conditions are provided for batch quality abnormity tracing and equipment intelligent maintenance.

A grinding device for scale-like metal powder comprises a driving rolling drum, a primary grinding drum, a secondary grinding drum, a grinding roller and a seal assembly, wherein the driving rolling drum is in a drum structure with one end sealed, the seal assembly seals the primary grinding drum, the secondary grinding drum and the grinding roller in the driving rolling drum, the lengths of the primary grinding drum, the secondary grinding drum and the grinding roller are slightly smaller than that of an inner cavity formed by the driving rolling drum and the seal assembly, the primary grinding drum is located in the driving rolling drum, the outer diameter bottom of the primary grinding drum contacts with the inner diameter bottom of the driving rolling drum, the secondary grinding drum is located in the primary grinding drum, the outer diameter bottom of the secondary grinding drum contacts with the inner diameter bottom of the primary grinding drum, the grinding roller is located in the secondary grinding drum, and the outer diameter bottom of the grinding roller contacts with the inner diameter bottom of the secondary grinding drum. All parts rotate by mutual friction, the gravity forms grinding force, and the difference of rotational linear speed forms rolling. The grinding device has the advantages that the processed scale-like micro powder is high in flattening ratio and stable in quality, the processing is quick and efficient, and the service life of the grinding device is long.

The invention relates to an isobutene preparation method, wherein problems of low conversion rate, low selectivity, easy catalyst deactivation, short regeneration period, and difficult process scaling-up of the isobutene preparation reaction through isobutane dehydrogenation in the prior art are mainly solved with the present invention. The technical scheme comprises that: isobutane is adopted as a raw material, enters at least a heat insulation fixed bed reactor at a reaction temperature of 500-650 DEG C under a reaction pressure of 0-0.5 MPa at an isobutane weight space velocity of 2-6 h<-1> according to an isobutane / hydrogen molar ratio of 1.5-4:1 and a water vapor / isobutane molar ratio of 1-6:1, and contacts a Pt-containing alumina catalyst to produce the isobutylene. With the technical scheme, the problem in the prior art is well solved, and the preparation method can be used for industrial production of isobutene preparation through isobutane dehydrogenation.

The invention provides a microporous eddy double-tube reactor and application thereof. The microporous eddy double-tube reactor comprises basic combination units, every basic combination unit is composed of an outer tube and an inner tube, the inner tube comprises a continuous phase inlet and outlet, one end of the outer tube is a dispersed phase inlet, and the other end of the outer tube is a closed end; between both ends of the inner tube, a group of continuous microporous arrays or a plurality of groups of discontinuous microporous arrays are distributed in the circumferential and axial directions of the tube wall, so that dispersed phase can form eddies inside the inner tube when passing through the wall of the inner tube. The microporous eddy double-tube reactor enables the dispersedphase to form eddies inside the inner tube after passing through the pores of the wall of the inner tube to strengthen mixing of process fluid, and particularly, can retard the phase separating process for processes long in reaction time. Meanwhile, the microporous eddy double-tube reactor can effectively divide the mass transfer and heat exchange process of dispersed phase and continuous phase into a plurality of different sections to effectively relieve acute heat exchange processes during process scale-up.