1888 results about "Piperazine" patented technology

The present invention relates to crystalline forms of salts of the KRas G12C inhibitor 2-[(2b)-4- [7-(8-chloro-1-naphthyl)-2-[[(25)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H -pyrido [3,4- d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile, pharmaceutical compositions comprising the crystalline forms, processes for preparing the crystalline forms and methods of use thereof.

The invention relates to an anti-static PP composite material and a preparation method thereof, and belongs to the technical field of high polymer materials. The antistatic PP composite material is prepared from the following components in parts by weight: 60 to 80 parts of PP resin, 10 to 20 parts of glass fiber, 0.1 to 0.5 part of a lubricant, 0.3 to 2 parts of a modified antistatic agent, 0.5 to 1.5 parts of a modified flame retardant and 0.2 to 0.8 part of an antioxidant, in the modified antistatic agent, an alkanolamide bond intermediate forms a conductive film, so that the resistivity is reduced, static dissipation is promoted, the material is endowed with lubricity, and the generation of static electricity is reduced; in addition, maleic anhydride forms a conductive layer and cooperates with quaternary ammonium salt to enhance hydrophilicity and accelerate charge transfer; a piperazine pyrophosphate derivative in the modified flame retardant and a phosphorus-nitrogen flame retardant cooperate to construct an expanded carbon layer to isolate a fire source and oxygen, so that the service life is prolonged; the anti-static PP composite material prepared by the invention not only has a good anti-static effect, but also has excellent flame-retardant and tensile properties.

The invention discloses a CO2 trapping absorbent which comprises 20%-50% of proton type ionic liquid, 20%-50% of a phase conversion driving agent and 20%-40% of water, and the phase inversion driving agent is one or a mixture of more of N, N-dimethyl formamide, N-methyl pyrrolidone, pentamethyldiethylenetriamine, tetramethylethylenediamine, tetramethylethylenediamine, tetramethylenediamine, tetramethylethylenediamine and dimethyl piperazine, and the phase inversion driving agent is one or a mixture of more of N, N-dimethyl formamide, N-methyl pyrrolidone, pentamethyldiethylenetriamine, tetramethylethylenediamine, tetramethylethylenediamine and dimethyl piperazine. The absorbent disclosed by the invention has the outstanding advantages of low viscosity, high absorption rate, high regeneration efficiency, high circulation capacity and low regeneration energy consumption, and has a good application prospect.

The invention discloses an organic amine composite absorbent for carbon capture and application thereof, and belongs to the technical field of carbon dioxide capture, the organic amine composite absorbent for carbon capture is in a solution state and comprises the following components: a main agent, an auxiliary agent, an accelerant A, an accelerant B and water; wherein the mass ratio of the main agent to the auxiliary agent is 2: (1-2); the mass ratio of the auxiliary agent to the accelerant A is 2: (1-2); the mass ratio of the accelerant A to the accelerant B is 2: (1-2); the total mass concentration of the main agent, the auxiliary agent, the accelerant A and the accelerant B in the organic amine composite absorbent for carbon capture is 30-40 wt%; the main agent is selected from N-methyldiethanolamine or N, N-diethyl ethanolamine, the auxiliary agent is selected from piperazine or hydroxyethyl ethylenediamine, the accelerant A is selected from triethylene glycol monomethyl ether and / or ethylene glycol monomethyl ether, and the accelerant B is selected from ethyl butyl ether and / or isobutyl ether. The organic amine composite absorbent for carbon capture has a wide application prospect in removal of carbon dioxide in flue gas.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising at least one compound chosen from PRN1008 and pharmaceutically acceptable salts thereof are also disclosed.

The invention belongs to the field of catalyst preparation and compound synthesis, and particularly relates to a composite metal catalyst, a preparation method and application of the composite metal catalyst in co-production of diethylenetriamine and piperazine. The composite metal catalyst consists of three parts, namely a main active component, an auxiliary active component and a carrier, the main active component is at least any one of Ni and Cu, the auxiliary active component is at least any one of Mg, Cr, Mn, Co, Sr, La and Ba, and the carrier is Al2O3. The invention also provides a method for co-production of piperazine from diethylenetriamine by using the composite metal catalyst. By adopting the method disclosed by the invention, the coproduction of the piperazine with high added value in the continuous synthesis process of the diethylenetriamine can be realized.

The invention belongs to the technical field of high polymer materials. The invention particularly relates to a halogen-free flame-retardant ablation-resistant polypropylene composite material as well as a preparation method and application thereof. The polypropylene composite material comprises 40-60% of flame-retardant modified master batch and 40-60% of long glass fiber reinforced polypropylene master batch, the flame-retardant modified master batch is prepared from the following raw materials in parts by weight: 24-44 parts of polypropylene resin, 5-15 parts of PPE resin, 2-5 parts of a compatilizer, 20-40 parts of piperazine substances, 10-20 parts of ammonium phosphate substances, 4-8 parts of surface modified superfine aluminum hydroxide and 0.3-1.5 parts of a processing aid. The content of the long glass fibers in the long glass fiber reinforced polypropylene master batch is 40-60wt%. PPE resin is introduced into a polypropylene halogen-free flame-retardant system, modified superfine aluminum hydroxide is compounded, halogen-free flame-retardant master batches and long glass fiber reinforced polypropylene master batches are uniformly compounded in proportion, and the halogen-free flame-retardant ablation-resistant material is obtained. While the high flame retardance of the material is maintained, the ablation resistance can be greatly improved, and the material is not burnt through after being continuously burnt for 10 minutes by a flame spray gun at the temperature of 1300 DEG C.

The invention discloses super-hydrophobic high-thermal-stability piperazine pyrophosphate and a preparation method thereof.The super-hydrophobic high-thermal-stability piperazine pyrophosphate comprises piperazine pyrophosphate, the surface of piperazine pyrophosphate is coated with a vesicle structure, and the vesicle structure is a self-assembly structure obtained after alcoholysis reaction of a polysulfide silane compound and piperazine pyrophosphate. According to the sulfur-containing silane material with piperazine pyrophosphate coated with the vesicle structure, piperazine pyrophosphate has super-hydrophobic performance due to the vesicle structure, super-hydrophobic durability is achieved, good water resistance and extremely low moisture absorption can be kept in a high-humidity environment, and the problem that piperazine pyrophosphate powder absorbs moisture and is agglomerated can be solved. The vesicle structure has the effects of blocking heat and substance transfer and reducing the thermal oxidation rate of PAPP, so that the piperazine pyrophosphate provided by the invention also has excellent thermal stability and final char forming performance, and is beneficial to reducing the dosage of the piperazine pyrophosphate in a flame-retardant high polymer material.

The invention relates to an application of a JAK inhibitor in preparation of a medicine for treating chronic kidney diseases, in particular to a compound 2-{N-[4-(4-methyl) piperazine] phenyl} amino-5, 6-dihydro-7-[3-(N-tert-butyl) sulfonamido] phenyl-pyrrolo [2, 3-d] pyrimidine or pharmaceutically acceptable salt thereof, and a preparation method of the compound 2-{N-[4-(4-methyl) piperazine] phenyl} amino-5, 6-dihydro-7-[3-(N-tertiary butyl) sulfonamido] phenyl-pyrrolo [2, 3-d] pyrimidine. The invention also relates to application of a pharmaceutical composition containing the compound in preparation of medicines for treating chronic kidney diseases. The compound has good treatment activity on chronic kidney diseases caused by various reasons, can remarkably reduce the inflammatory factor level of kidney tissue, further reduces kidney injury and fibrosis lesion degree, is high in safety, is expected to become a new medicine for treating the chronic kidney diseases, and has wide clinical application prospects.

A method of formulating novel humic material is disclosed comprising mixing one or more portions of Dimethylphenylpiperazinium (DMPP) with one or more portions of N-(N-butyl) thiophosphoric triamide (NBPT) with one or more portions of Isobutylidene-diurea (IBDU) with one or more portions of Polyaspartic Acid with one or more portions of Chitosan and a portion of Mycorrhizae and Rhizobia to form a portion of biostimulant material; obtaining a portion of seaweed harvest and crushing and drying said portion of seaweed to form a portion of seaweed powder; Obtaining a portion of leonardite and crushing said portion of leonardite to form a portion of humic raw material; mixing one or more portion of animal manure with one or more portion of stover with one or more portion of organic waste to form a portion of compositing mix and composting said compositing mix to form a portion of composted material; obtaining a portion of plant waste and subjecting said portion of plant waste through an anaerobic combustion to form a portion of bio char; mixing said portion of bio char with said portion of composted material with said portion of humic material to form a portion of humic processed material; adding a portion of artificial taggant to said humic processed material to form tagged humic material; mixing said tagged humic material with said portion of biostimulant material to form a portion of biostimulant humic material; adding a taggant to said portion of biostimulant humic material to form a portion of tagged biostimulant humic material; mixing one or more portion of phosphorus with a portion of potassium and a portion of nitrogen and a portion of trace minerals to form portion of raw fertilizer; mixing said portion of raw fertilizer with said portion of tagged biostimulant humic material to form a portion of tagged fertilized biostimulant humic material.

The invention provides a water-based intumescent fireproof coating as well as a preparation method and application thereof, and relates to the technical field of coating materials. The water-based intumescent fireproof coating is prepared from the following components in parts by weight: 25 to 35 parts of water-based silicone acrylic emulsion, 40 to 60 parts of flame retardant, 15 to 25 parts of water, 5 to 10 parts of titanium dioxide and 1 to 5 parts of coalescing agent, wherein the flame retardant is ammonium polyphosphate modified by 1-cyclohexylpiperazine. According to the water-based intumescent fireproof coating disclosed by the invention, the silicone acrylic emulsion is used as a main film forming substance, the 1-cyclohexylpiperazine modified ammonium polyphosphate is used as a flame retardant, and the titanium dioxide is used as a filler to form a fireproof intumescent system, so that the water-based intumescent fireproof coating has the advantages of simple production process, excellent performance, environment friendliness and the like; and the prepared fireproof coating has good fireproof performance and durability.

The invention relates to the technical field of conductive materials, in particular to a high-concentration dispersion system and a preparation method thereof. The high-concentration dispersion system comprises a conductive agent, a dispersing agent, a solvent and a viscosity reduction auxiliary agent, the conductive agent is modified carbon nanotubes, the dispersing agent is modified polyvinylpyrrolidone, the solvent is N-methyl pyrrolidone or deionized water, and the viscosity reduction auxiliary agent is piperazine anhydrous; wherein the modified carbon nano tube is obtained by mixing and heating a carbon nano tube and a mixed acid solution of nitric acid and sulfuric acid, then cooling, filtering, washing, drying, then dispersing in 75% ethanol, and finally adding 3-[3-carboxyl allylamido] propyltriethoxysilane for modification; the modified polyvinylpyrrolidone is obtained by heating polyvinylpyrrolidone at 310-330 DEG C and then oxidizing the polyvinylpyrrolidone. The conductive agent content of the high-concentration dispersion system is high, the conductive agent accounts for 15%-20% of the high-concentration dispersion system by mass, and the high-concentration dispersion system is low in viscosity, high in dispersity and good in conductivity.

Provided are piperazine fused ring system derivatives of formula (I), pharma- ceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising said compounds, and uses of said compounds as polyadenosine diphosphate ribose (ADP-ribose) polymerase (PARP) inhibitors in the treatment of related diseases such as cancer, inflammation, metabolic diseases, cardiovascular diseases, immune diseases and psychiatric diseases. [Formula 1] JPEG2025503798000246.jpg20169

The invention discloses a high-sensitivity cardiac troponin-T electrochemiluminescence detection kit. The kit comprises a magnetic microsphere reagent coated by a high-sensitivity cardiac troponin-T capture antibody and a high-sensitivity cardiac troponin-T detection antibody reagent labeled by an electrically neutral ruthenium compound, the structural general formula of the electrically neutral ruthenium compound is # imgabs0 # n = 0-9; the magnetic microsphere reagent coated with the high-sensitivity cardiac troponin-T capture antibody comprises a magnetic microsphere coated with the high-sensitivity cardiac troponin-T capture antibody and a diluent; the electrically neutral ruthenium compound labeled high-sensitivity cardiac troponin-T detection antibody reagent comprises an electrically neutral ruthenium compound labeled high-sensitivity cardiac troponin-T detection antibody and a diluent; the diluent is prepared from piperazine-1, 4-diethyl sulfonic acid or 3-(N-morpholinyl)-2-hydroxy propanesulfonic acid. When the high-sensitivity cardiac troponin-T electrochemiluminescence detection kit is used for detection, a reaction system does not contain streptavidin coated magnetic beads or biotinylated antibodies, so that interference of biotin in a sample is avoided.

The invention relates to the field of medicine synthesis, and particularly discloses a preparation method of abesilib and an intermediate thereof. The invention relates to an abesiril intermediate, which is 4-chloro-5-fluoro-2-(methylsulfonyl) pyrimidine (IV) and 4-fluoro-6-(5-fluoro-2-(methylsulfonyl) pyrimidine-4-yl)-1-isopropyl-2-methyl-1H-benzo [d] imidazole (V). The invention further provides a preparation method of the abesiril intermediate. And carrying out nucleophilic substitution reaction on the abesilib intermediate V and 5-[(4-ethyl piperazine-1-yl) methyl] pyridine-2-amine to prepare the abesilib. According to the preparation method, the raw materials are cheap and easy to obtain, the reaction selectivity of functional groups is high, ectopic impurities generated by a halogen atom competition reaction are effectively avoided, meanwhile, introduction of heavy metal palladium can be reduced, and therefore the cost is reduced. The synthetic route is simple, the atom economy is high, the controllability in production is high, and the method is suitable for industrial production.

The invention discloses a surface-enhanced tryptophan modified nanofiltration membrane as well as a preparation method and application thereof. Belongs to the field of water treatment membrane preparation. The invention aims to solve the technical problems of non-uniform pore size distribution and surface hydrophobicity of the conventional nanofiltration membrane. The method comprises the following steps: adding tryptophan into a piperazine water-phase solution, and carrying out interfacial polymerization with oil-phase trimesoyl chloride to prepare the tryptophan modified nanofiltration membrane. According to the preparation method, the diffusion rate of the piperazine monomer can be adjusted in the interfacial polymerization process by utilizing a similar surfactant structure of tryptophan, meanwhile, the tryptophan has hydrophilicity and can improve the hydrophilicity of the surface of an active layer, and the prepared modified nanofiltration membrane is reduced in molecular weight cut-off, improved in surface hydrophilicity and good in water resistance. The retention rate of organic micro-pollutants is improved, and meanwhile, good anti-pollution performance is achieved.

The present invention relates to compounds possessing a fused 6,5- or 6,6-bicyclic heterocycle that is attached to a piperidine or piperazine group that is in turn linked to an indole moiety, to compounds having similar core structures, and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present invention further relates to methods of synthesising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by Factor B inhibition.

The invention develops an efficient conversion method for synthesizing the anti-schizophrenia drug blonanserin. According to the preparation method, commercially available cyclooctanone, 1-(4-fluorophenyl) prop-2-ene-1-ketone and NH4X (X = F, Cl, Br or I) are subjected to a three-component [2 + 1 + 3] form cascade cyclization method, then m-CPBA is used for oxidation to obtain nitrogen oxide, and finally the nitrogen oxide reacts with N-ethyl piperazine to obtain the blonanserin compound. The two methods respectively obtain the functional group tolerant blonanserin compound with high yield. The two interesting methods have the characteristics of simple operation, easily available starting materials, mild reaction conditions, good functional group tolerance, high atom economy and the like. In addition, compared with a traditional method (at least five steps are needed), the strategy can provide a good synthesis route for the anti-schizophrenia drug blonanserin with a highly functionalized structure.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The application discloses a specific palmitoyl transferase inhibitor and application thereof, and an active ingredient of the palmitoyl transferase inhibitor is 4-(3-(2-(trifluoromethyl)-9H-thioxanthene-9-ylidene)propyl)-1-piperazine ethanol or a salt thereof. Current palmitoylation inhibitors, 2-bromohexadecanoic acid (2-BP), cerulenin and tunicamycin can all inhibit protein palmitoylation in cells, but all are not selective. And the existing palmitoylation inhibitors are similar to endogenous fatty acids, and inevitably affect lipid metabolism in the body, which limits the clinical application. The application discloses, for the first time, the application of 4-(3-(2-(trifluoromethyl)-9H-thioxanthene-9-ylidene)propyl)-1-piperazine ethanol as a specific palmitoyl transferase inhibitor, and the palmitoyl transferase inhibitor is better in specificity and reversible in inhibition.

The invention discloses an impact-resistant flame-retardant ABS (Acrylonitrile Butadiene Styrene) material and a preparation method thereof. The material is prepared from the following raw materials in parts by mass: 67-80 parts of ABS resin, 15-28 parts of an intumescent flame retardant, 5-8 parts of a flexibilizer, 2-5 parts of a compatilizer and 0.7 part of a processing aid, the intumescent flame retardant is composed of a piperazine flame retardant, a hypophosphite flame retardant and / or a nitrogen flame retardant. The flame-retardant ABS material disclosed by the invention has excellent mechanical properties and flame retardance at the same time.

The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.

The invention discloses a PARP1 selective protein degradation agent and an application of the PARP1 selective protein degradation agent in tumor resistance. The degradation agent has the following structural formula. Wherein the 3-ethyl-7-((4-(pyridine-3-yl) piperazine-1-yl) methyl) quinoxaline-2 (1H)-ketone part is a PARP1 target protein ligand, and L is a connecting unit; and B is an E3 ubiquitin ligase ligand. The PARP1 selective protein degradation agent prepared by the preparation method disclosed by the invention can be used for effectively degrading PARP1 protein, inhibiting cell proliferation and inducing tumor cell apoptosis. Meanwhile, when the compound is combined with chemotherapeutic drugs, the effect of enhancing the chemotherapeutic effect is achieved, almost no physiological toxicity exists, and the compound is expected to provide an ideal way for improving treatment of various diseases caused by PARP1 excessive activation. # imgabs0 #

The invention provides a method for detecting nitrosamine impurities in a starting material N-Boc-piperazine of tandospirone citrate, which comprises the following steps: carrying out linear gradient elution on a chromatographic column by taking octadecylsilane chemically bonded silica as a filler, a potassium hexafluorophosphate solution as a mobile phase A and acetonitrile as a mobile phase B; the pH value of the potassium hexafluorophosphate solution ranges from 4.3 to 5.5. The method is high in specificity, high in detection sensitivity and accuracy and good in linearity, and the nitrosamine impurity 1-nitrosopiperazine contained in N-Boc-piperazine can be accurately measured. According to the method, the technical barrier of detecting the nitrosamine impurities by using a gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry method at present is overcome, the detection cost is reduced, and meanwhile, other impurities contained in the method do not influence the accurate detection of the nitrosamine impurities.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention relates to the technical field of membrane separation, in particular to a preparation method of a pH-step-by-step thermocuring regulation sodium-magnesium separation nanofiltration membrane. The method comprises the following steps: (1) pre-treating a base membrane; (2) preparation and treatment of an aqueous phase solution: S1, preparing the aqueous phase solution according to mass fraction: sequentially adding 1.2%-1.6% of piperazine, 0.10%-0.14% of triaminopyrimidine and 0.14%-0.18% of polyethylene glycol into deionized water, and stirring until the piperazine, the triaminopyrimidine and the polyethylene glycol are completely dissolved to form the aqueous phase solution; s2, adjusting the pH value of the water-phase solution to 10-11 by using hydrochloric acid; s3, pouring the water-phase solution of which the pH is adjusted on the surface of the pretreated base membrane, standing, and blow-drying to form a uniform water-phase layer; (3) interfacial polymerization reaction: S1, preparing an oil phase solution: adding 0.10-0.14% of trimesoyl chloride into n-hexane, and performing ultrasonic treatment until the trimesoyl chloride is completely dissolved; s2, pouring the oil-phase solution on the surface of the base membrane subjected to water-phase treatment, and after reaction, pouring out redundant solution to form a polyamide separation layer, so as to obtain a membrane sheet; (4) performing a step-by-step thermocuring process; and (5) cleaning and storing.