96 results about "Atom economy" patented technology

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

This invention belongs to the field of medicinal chemistry technology, specifically relating to a continuous preparation method of β-lactamase inhibitor intermediates using a fixed-bed reactor and its application in drug production. This method features good atom economy, low heavy metal residue, intrinsic safety, and ease of industrial-scale production.

This invention relates to the field of organic synthetic chemistry, specifically to a polysubstituted furan compound and its synthetic method, wherein the method comprises... β Using ketone sulfones and olefins as starting materials, polysubstituted furans are synthesized via a [3+2] cycloaddition reaction in the presence of a copper catalyst and an oxidant. This invention employs cuprous bromide as the catalyst and di-tert-butyl peroxide (DTBP) as the oxidant, reacting in dimethyl sulfoxide solvent at 100°C–130°C for 6–24 h. This method offers advantages such as high atom and step economy, broad substrate applicability, good functional group tolerance, excellent position selectivity, and high yield, with a maximum yield reaching 84%. It is suitable for large-scale synthesis and provides a new strategy for the synthesis of furans in medicinal chemistry and materials science.

This invention relates to the field of chemical synthesis technology, specifically disclosing a method for preparing vinyl ethylene carbonate. The method uses glycidyl as a starting material, first converting it to glycidaldehyde via a mild oxidation reaction with high selectivity. Then, using a cross-linked imidazole polymeric ionic liquid as a catalyst, glycidaldehyde undergoes an atom-economical cycloaddition reaction with carbon dioxide to construct a cyclic carbonate intermediate. Finally, under catalytic conditions, a condensation reaction introduces a vinyl functional group to obtain the vinyl ethylene carbonate product. This invention uses widely available, low-toxicity, and inexpensive glycidyl instead of highly toxic raw materials, and utilizes greenhouse gas carbon dioxide as a carbonyl source for resource utilization. The process route is highly atom-economical, the reaction conditions are mild, and the catalyst is easy to separate, recover, and recycle, effectively solving the prominent problems of high raw material toxicity, expensive catalysts, and difficult byproduct treatment in traditional preparation techniques.

The application discloses a preparation method of a non-conjugated functionalized olefin compound, and the method is carried out in a cobalt / photocatalysis dual catalytic system which is composed of a cobalt catalyst, a ligand, a photocatalyst, a hydrogen source, a base and a solvent. β The target product is efficiently and selectively synthesized through reaction of an ethylenic compound or a halogenated compound or an electron-deficient olefin represented by formula (2) with acetylene as a C2 synthetic unit. The application adopts a cobalt / photocatalysis dual catalytic synergistic mechanism, has mild conditions (normal temperature and pressure, visible light driving), uses water as a green hydrogen source, uses acetylene as a cheap C2 source, has high atom economy, has good substrate universality, and the compound represented by formula (1) is easy to be prepared through Friedel-Crafts acylation or is commercially available, and the compound represented by formula (1) is easy to generate the compound (III) represented by formula (2) under the action of a base. The obtained non-conjugated olefin is a key intermediate for synthesizing high-value-added fine chemicals such as fragrances and insect pheromones, and has wide application prospects.

This invention discloses the preparation of a high-efficiency paraformaldehyde sulfonic acid catalyst and its application in the catalytic synthesis of C14 secondary alcohols, relating to the field of olefin catalytic hydration technology. The catalyst is prepared by high-temperature polymerization of p-toluenesulfonic acid and paraformaldehyde under concentrated sulfuric acid catalysis. C14 olefins, the paraformaldehyde sulfonic acid catalyst, isopropanol, and deionized water are added to a reactor, and a catalytic reaction is carried out at a certain temperature. The product conversion rate is 0.46%, and the selectivity is >99%. The catalyst of this invention is simple to prepare, has a well-developed mesoporous structure and sufficient acidic sites, provides mild catalytic hydration reaction conditions, exhibits good olefin conversion and secondary alcohol selectivity, and is easily recoverable and reusable. The process is green and environmentally friendly, with high atom economy, and is beneficial for the industrial conversion and application of high-value utilization of Fischer-Tropsch olefins from coal-to-oil.

The application discloses a synthesis method of 2-aryl-4-phosphoryl-4H-chromene compounds, which comprises the following steps: dissolving 2-hydroxychalcone, diaryl phosphine oxide and mercury triflate in an organic solvent, and reacting at 80-100 DEG C; after the reaction is completed, 2-aryl-4-phosphoryl-4H-chromene compounds are obtained through separation and purification; the synthesis method is simple, the reaction condition is mild, and the operation is convenient; the raw materials are easy to prepare; the reaction byproduct is water; and the method has the advantages of high atomic economy, green environmental protection and the like.

This invention discloses a dual-enzyme system for catalyzing the synthesis of L-cysteine ​​from D-serine and its applications. This dual-enzyme system achieves the asymmetric synthesis of L-cysteine ​​from D-serine with a substrate conversion rate of 99% and a product yield >110%. The catalytic process of this invention is simple, with no byproducts generated and easy subsequent separation. Therefore, it has advantages such as high atom economy, high product optical purity, mild reaction conditions, environmental friendliness, and simple product post-processing. It has great potential for the industrialization of low-cost and controllable multi-enzyme preparation of L-cysteine.

This invention discloses a method for synthesizing a tenapano hydrochloride intermediate. The synthesis method includes the following steps: (1) condensing the compound 3-bromophenylacetaldehyde and the compound N-methyl-(2,4-dichlorophenyl)methylamine under dehydration conditions to obtain an enamine intermediate; (2) subjecting the enamine intermediate to an intramolecular cyclization reaction in the presence of an acid catalyst to obtain the tenapano hydrochloride intermediate 4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline. The synthetic route provided by this invention requires only two steps to construct the key framework, and has the advantages of short reaction steps, high overall yield, and no need to use highly toxic liquid bromine. This process has high atom economy, reduces the emission of waste gas, wastewater, and solid waste, and is suitable for large-scale industrial production under mild conditions.

The application discloses a kind of 1,2-naphthalene dicarboxylic acid diethyl compound photocatalytic synthesis method, it includes the following steps: styrene compound, alpha-diazo iodonium salt and catalyst are dispersed in organic solvent, then coupling cyclization reaction is carried out under light, obtains 1,2-naphthalene dicarboxylic acid diethyl compound.The 1,2-naphthalene dicarboxylic acid diethyl compound photocatalytic synthesis method of the application has the advantages that raw material is cheap and easy to obtain, simple and efficient, reaction condition is mild, atom economy is high, product is easy to purify, production cost is low, green and safe, suitable for large-scale industrial production.

This invention belongs to the field of fine chemical synthesis technology and relates to a method for preparing 2,4-diaminodiphenylamine, an intermediate in p-phenylenediamine antioxidants. Aniline and m-dinitrobenzene undergo a catalytic nucleophilic substitution reaction under negative pressure to obtain a reaction system with 2,4-dinitrodiphenylamine as the main product. The reaction system with 2,4-dinitrodiphenylamine as the main product is diluted with methanol and then subjected to catalytic hydrogenation. After the reaction, post-treatment yields 2,4-diaminodiphenylamine. This invention uses m-dinitrobenzene as the reactant, which is halogen-free and does not produce halogen-containing wastewater. It also has lower requirements for the corrosion resistance of production equipment, higher atom economy, and is more in line with the concept of green chemistry. The solvent and catalyst in this invention are recyclable, resulting in low cost.

The application provides a method for synthesizing 2,4,4-trimethyl-2-pentanol from diisobutene by esterification hydration, comprising the following steps: S1, esterification hydration reaction: diisobutene, organic acid and water are reacted in the presence of a catalyst; S2, separation and recovery: S3, hydrogenation reaction: 2,4,4-trimethyl-2-pentyl acetate recovered in step S2.5 is subjected to catalytic hydrogenation to generate a hydrogenation reaction liquid containing 2,4,4-trimethyl-2-pentanol and ethanol; S4, the hydrogenation reaction liquid obtained in step S3 is separated, and TMPOL is synthesized by using the above method with the organic acid as a medium, the single-pass conversion rate of diisobutene can reach 50%, and the selectivity reaches 99%. The process has the characteristics of high efficiency and high atom economy, and has great industrialization potential.

This invention belongs to the field of aromatic ring hydrogenation catalyst technology, and relates to a mixed oxide supported ultra-low ruthenium-based catalyst, its preparation method, and its application. This invention improves the acidic sites at the catalyst surface by controlling the proportion of the metal oxide support. Simultaneously, it utilizes the mesoporous structure and high specific surface area of ​​the support, and leverages the ruthenium catalytic active sites at the hydroxyl coordination sites on the support surface to effectively avoid the problem of catalytic metal aggregation and deactivation. This enhances the stability of the active metal in the catalytic material, inhibits its aggregation during the reaction, and thus significantly reduces the ruthenium loading of the catalyst. Ultimately, it obtains a catalytic system with high conversion, high selectivity, high TON value, and high TOF value, meeting the atom economy and environmental friendliness requirements of industrial production.

This invention provides a method for preparing (S)-2-amino-4-chlorobutyric acid alkyl ester and its salt, comprising the following steps: (1) reacting a compound of formula I with a base to generate a compound of formula II; (2) reacting a compound of formula II with a chlorinating agent to generate a dichloride; and (3) reacting the dichloride with an alcohol to generate a compound of formula III. The preparation method of this invention improves the physicochemical properties of the reaction by constructing a dimer intermediate from the intramolecular bifunctional group of the compound of formula I, then achieving hydroxyl chlorination with a chlorinating agent, and finally, under the action of an alcohol, achieving the one-pot preparation of (S)-2-amino-4-chlorobutyric acid alkyl ester hydrochloride. This method effectively reduces the amount of chlorinating agent and alcohol used, significantly improves the atom economy and effective conversion rate of the reaction, has mild reaction conditions, produces products without significant racemization, has controllable impurities, and simplifies post-processing and purification. The by-product waste salt can be recycled, making it suitable for large-scale industrial production.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

This invention relates to a method for the trivalent rhodium-catalyzed synthesis of 2-cyanenylindole compounds, belonging to the field of organic chemistry. The method uses [Cp*RhCl2]2 as a catalyst and N-pyrimidine indole compounds and alkynyl-N-cyano-N-phenyl-p-toluenesulfonamide compounds as raw materials. The reaction is carried out in an organic solvent at 60°C with lithium chloride assistance, and the 2-cyanenylindole compounds are obtained after separation and purification. This invention utilizes a cyano group migration strategy to achieve a tandem reaction of indole C-H alkenylation and cyano group introduction, constructing C-C and C-CN bonds in one step, with a target product yield of 31%–82%. Compared with existing technologies, this invention uses a non-toxic cyanide source instead of traditional highly toxic cyaniding reagents, and has advantages such as simple operation, mild reaction conditions, wide substrate applicability, and high atom economy.

The application provides a preparation method of a pyridopyrimidinone compound, and comprises the following steps: reacting a 2-bromonicotinamide compound and a formamide in an organic solvent in the presence of an inorganic base to obtain the pyridopyrimidinone compound. The method is metal-free catalysis, has mild reaction conditions, high atom economy, wide substrate applicability and simple operation, provides a new way for rapidly constructing a library of the heterocyclic compounds, and has wide application prospects in the fields of medicinal chemistry and organic synthesis.

This invention provides a Cu-supported Y molecular sieve catalyst, its preparation method and application, and a method for preparing dimethyl carbonate using carbon dioxide. The method for preparing dimethyl carbonate using carbon dioxide includes: reacting carbon dioxide and dimethyl ether in the presence of a copper-containing catalyst to produce dimethyl carbonate; the copper-containing catalyst includes a Y molecular sieve and copper supported on the Y molecular sieve. This invention uses a copper-supported Y molecular sieve to catalyze the reaction of dimethyl ether with carbon dioxide. The reaction conditions are mild, the reaction product contains only dimethyl carbonate, with no byproducts generated, achieving 100% atom economy. It utilizes the greenhouse gas CO2, reducing environmental pollution. Furthermore, since no water byproduct is generated in the reaction, the adverse effects of water on catalyst activity and dimethyl carbonate selectivity are effectively avoided, significantly improving the yield of dimethyl carbonate. The operation is simple, the process conditions are mild, reducing costs and improving industrial production efficiency.

The application belongs to the technical field of organic hydrogen storage material preparation, and particularly relates to a preparation method of a pyrrolo[2,3-e]indole hydrogen storage material. The preparation method comprises the following steps: in a reactor, benzene diamine and o-diol, catalyst alpha and catalyst beta are put in, then reaction is carried out at 25-250 DEG C for 0.1-48 hours, and pyrrolo[2,3-e]indole compounds are obtained; the catalyst alpha is a catalyst with hydrogen activation ability and dehydrogenation ability; the catalyst beta is an acid with Hammett acidity function H0 < 0. The application provides a method for preparing the hydrogen storage material pyrrolo[2,3-e]indole compounds, benzene diamine and diol are used for reaction, two catalysts are used, and a one-step closed double ring is realized, and the atom economy is high. The starting material of the application is cheap and easy to obtain, and is easy to be industrialized, and helps hydrogen energy industry. The method of the application has high universality and high substrate tolerance.

This invention discloses a method for preparing imidazolidinone derivatives, belonging to the field of pharmaceutical synthesis technology. The method involves reacting isocyanate and polysubstituted propargylamine as raw materials in an organic solvent under rare-earth Lewis acid catalysis to obtain the target imidazolidinone derivative. This invention features a mild reaction, simple operation, improved atom economy and synthetic efficiency, and good functional group compatibility.

This invention provides a 1,2-diacylbenzene compound, its synthesis method, and its applications. The synthesis method includes: heating and reacting a mixture containing an arylethyl ketone compound, an arylbutyl ketone compound, a catalyst, a ligand, an oxidant, a base, and a solvent under a nitrogen atmosphere; followed by cooling, concentration, and purification to obtain the 1,2-diacylbenzene compound. This synthesis method uses readily available and inexpensive ketone starting materials as the starting point for the synthetic route, avoiding the use of excessive metal compounds as oxidants. It also avoids the disadvantages of requiring pre-synthesis of starting materials and the difficulty in storing highly reactive materials, greatly reducing synthesis costs and post-processing difficulties. Furthermore, it allows for large-scale reaction experiments, produces high-purity products, and is an easy-to-operate, atom-economical, highly selective, and efficient method for synthesizing 1,2-diacylbenzene compounds.

This invention discloses an indoline fused heterocyclic compound, its preparation method, and its applications, belonging to the field of pharmaceutical synthesis technology. The method includes the following steps: using quinone imine monoketal and α,β-unsaturated cycloalkenyl ether as raw materials, and employing a Brønsted acid-phosphonic acid catalyst, a Brønsted acid-catalyzed [3+2] tandem cyclization reaction is carried out to obtain the indoline fused heterocyclic compound. The method provided by this invention features readily available raw materials and mild conditions, while also exhibiting high regioselectivity, chemoselectivity, and atom economy. The product can be efficiently separated by column chromatography, providing an excellent pathway for the large-scale preparation of this type of compound. Furthermore, the indoline fused heterocyclic compound provided by this invention has a significant inhibitory effect on the growth of human cervical cancer cells (HeLa), demonstrating good antitumor biological activity, which is of great positive significance for promoting the development of antitumor drugs.

This invention belongs to the fields of pharmaceutical chemistry and photocatalysis, and discloses a method for the photocatalytic synthesis of fulvestrant intermediates using pentafluorochloroethane and its applications. The method uses allyl ester compounds as substrates and pentafluorochloroethane (Freon-115) as a perfluoroalkylating agent. Under visible light irradiation, a specific photocatalytic redox system is constructed, and a boron-containing activator is introduced to synergistically activate the inert C-Cl bond, achieving the pentafluoroethylation-hydrogenation reaction of allyl esters to efficiently synthesize pentafluoropentyl benzoate. The method of this invention features mild reaction conditions, avoiding the use of highly toxic tin reagents in traditional processes, and simultaneously achieving high-value utilization of industrial waste gas Freon-115, demonstrating significant atom economy and promising industrial application prospects.

The application discloses a clean production method of oxyfluorofenner, recycles 2-chloro-4-trifluoromethyl phenol potassium by-product existing in a double etherization method process, and applies the by-product to synthesis of oxyfluorofenner, integrates a process route, opens up a new synthesis path, and solves the problem that the double etherization method by-product 2-chloro-4-trifluoromethyl phenol cannot be effectively utilized in the prior art method. Further exploration is made on recycling and utilization of 2-chloro-5-trifluoromethyl phenol potassium by-product and recycling of solvents in each step, atom economy of the process is significantly improved, process cost is reduced, yield of the target product oxyfluorofenner is improved, the method is environment-friendly, and is suitable for industrial production.

The application discloses a kind of continuous flow photocatalytic decarboxylation preparation biological hydrocarbon method, belong to the technical field of biofuel preparation.The method includes the following steps: high fatty acid compound, hydrogen atom transfer catalyst and acridine photocatalyst are dissolved in organic solvent, and mixed solution is obtained;The mixed solution is passed into circulating continuous flow light reactor, and photocatalytic decarboxylation reaction is carried out at room temperature for 12-24 hours, and reaction liquid is obtained;Reaction liquid is separated by reduced pressure distillation, and the biological hydrocarbon compound after decarboxylation is obtained.The application uses continuous flow light reactor to strengthen mass transfer and heat transfer efficiency, solves the problem that light penetration depth is limited in traditional batch photoreactor, and reaction is not uniform;Metal-free catalytic system is used, and the use of noble metal and potential residual risk is avoided.The method has mild reaction condition, higher product yield, good atom economy, and for unsaturated high fatty acid, olefin configuration can be maintained before and after decarboxylation, and has good industrial application prospect.

The present application relates to a kind of conjugated microporous polymer photocatalytic preparation aryl sulfone group ethylene compound based on method, the method of the present application uses the CMPs as photocatalyst with cheap chemical stilbene, sulfonyl chloride as raw material, uses triarylamine unit construction, with light energy as energy source, by in-situ formation electron donor-acceptor (EDA) complex realizes stilbene sulfonylation, with atom economy, step simplicity, efficient, green and environmentally friendly synthesis route with low price, to adapt to the requirement of industrial application, the synthesis method of the present application is more green, environment-friendly and wide application range.