245 results about "Atom economy" patented technology

The invention discloses a preparation method of 6-nitro-m-cresol, and belongs to the technical field of organic synthesis.The method comprises the steps that raw materials are subjected to esterification, water washing, sulfonation, nitration, desulfonation and refining in sequence, and the 6-nitro-m-cresol is obtained. According to the method, it can be guaranteed that the intermediate product is the 6-nitro derivative, generation of isomer impurities such as 2-site and 4-site is greatly reduced from the source, the reaction path is clear, and atom economy is good. The method does not need to depend on complicated means such as time-consuming column chromatography or precise fractionation, the requirement for high purity can be met only through conventional extraction and crystallization operation, the technological process is simple, the method is very suitable for large-scale production, and the product purity (measured through HPLC (High Performance Liquid Chromatography)) can stably reach 98% or above.

The invention belongs to the technical field of synthesis of 2, 3-dipicolinic acid, and relates to a catalyst for synthesizing 2, 3-dipicolinic acid as well as a preparation method and application thereof, the catalyst is prepared from a carrier, and active components and auxiliaries loaded on the carrier; the carrier is boron nitride modified aluminum oxide, the active component is palladium-cobalt bimetal, and the auxiliary agent is magnesium; the catalyst comprises the following components in percentage by mass: 0.2 wt%-3wt% of palladium, 0.5 wt%-4wt% of cobalt, 0.05 wt%-0.3 wt% of magnesium, 5wt%-15wt% of boron nitride and the balance of an aluminum oxide carrier. The catalyst is prepared by adopting an ultrasonic-assisted sol-gel method, so that high dispersion and strong interaction of active components are realized. The catalyst shows high catalytic activity, high selectivity and excellent stability in a dichloropyridine carbonylation reaction, carbon monoxide is used as a carbonyl source, the atom economy is high, and the green chemical requirement is met.

The invention discloses a method for synthesizing a benzodithiepinone derivative through metal-free catalysis, and belongs to the field of organic synthesis. According to the method, benzo disulfonylphenol ketone and alkyne are taken as raw materials, a dual-catalysis system composed of triethylene diamine and bis (diphenylphosphine) methane is adopted, a heating reaction is performed in a 1, 4-dioxane solvent, and the target seven-membered sulfur heterocycle (benzo [e] [1, 4] dithiepin-5-ketone compound) is obtained through separation and purification. According to the method, the problem of regioselective sulfuration of alkyne is effectively solved through a synergistic catalysis mechanism of organic amine and organic phosphine, and high-precision cyclization reaction of benzobissulfonylphenol ketone and alkyne is realized. The process is mild in reaction condition, free of inert gas protection, simple and convenient to operate and good in functional group tolerance, the atom economy can reach 100%, and an efficient and practical synthesis way is provided for construction of the benzo [e] [1, 4] dithiepin-5-ketone compound with a novel structure.

The application discloses a mass transfer enhanced gas-liquid reactor, which is characterized in that a feeding inlet and a tail gas outlet are arranged on a reactor shell, and a discharging outlet is arranged at the bottom; a stirring device comprises at least one group of stirring paddles arranged in the reactor shell; a gas distribution device is fixedly connected in the reactor shell and comprises an outer cover with an upper opening and a lower opening and a gas distributor sleeved in the outer cover, a gas-liquid passage with an annular cross section is formed between the outer cover and the gas distributor, a longitudinal section of the gas-liquid passage is S-shaped, a gas distribution hole is arranged on the side, and a gas inlet pipe is communicated with the gas distribution hole. The mass transfer enhanced gas-liquid reactor has the advantages of promoting the dissolution and transmission of gas, greatly improving the gas atom economy, saving energy, uniform stirring, complete fermentation, fast reaction speed and the like.

The application discloses a kind of S-delta-substituted caprolactam chemical / enzyme series preparation method, and the specific preparation method is: 1-substituted high allyl amine occurs dynamic kinetic resolution reaction with acrylic ester compound under the catalysis of alkaline protease (special treatment) and generates S-acryl (1-substituted high allyl) amine, then the product occurs intramolecular olefin metathesis under the catalysis of Grubbs reagent and finally generates S-delta-substituted caprolactam shown in formula (1), wherein, substituent R is phenyl, halogenated phenyl or C2-C12 alkyl.The application has mild reaction condition, is conducive to reducing the equipment requirement of preparation process, improves synthesis safety and economy;Secondly, the reaction course of the method is simple, and single configuration S-delta-substituted caprolactam can be obtained by one-pot reaction, with very high atom economy.

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

The invention discloses a preparation method of an omariglone key intermediate, which comprises the following steps: under the common catalytic action of a catalyst and a ligand, taking 4-bromo-2, 6-dimethyl fluorobenzene and hydrazine hydrate as initial raw materials, adding an additive and a solvent, and synthesizing the omariglone key intermediate under a heating condition. The preparation method provided by the invention is simple to operate, mild in reaction condition and high in atom economy, the synthesis cost is reduced, and industrial-grade large-scale production is realized.

The invention relates to a co-production preparation method of dialkyl phosphate and tetraalkyl ammonium sulfate, which comprises the following steps: trialkyl phosphate and trialkylamine are subjected to a first reaction at a first temperature, then a reaction system and excessive sulfuric acid are subjected to a second reaction at a second temperature in the presence of water, and the first temperature is higher than the second temperature; after the reaction is finished, adding an extracting agent to extract the system, and separating to obtain an organic phase and a water phase; removing the extracting agent in the organic phase to obtain dialkyl phosphate; adding tetraalkyl ammonium hydroxide into the water phase until the water phase is neutral or nearly neutral to obtain a water solution containing tetraalkyl ammonium sulfate. According to the method, the dialkyl phosphate can be obtained, the tetraalkyl ammonium sulfate salt with high added value can be obtained, the raw materials are easy to obtain, the process route is simple, the atom economy is high, the method is environment-friendly, the operation is simple, and the cost is low.

This invention belongs to the field of medicinal chemistry technology, specifically relating to a continuous preparation method of β-lactamase inhibitor intermediates using a fixed-bed reactor and its application in drug production. This method features good atom economy, low heavy metal residue, intrinsic safety, and ease of industrial-scale production.

The invention provides a method for preparing a chiral helicene compound through cyclization reaction of an iridium-catalyzed 3-aryl indazole biaryl compound and disubstituted alkyne. The method comprises the following steps: under the action of an iridium catalyst, a chiral cyano phosphorus-oxygen ligand and an additive, carrying out an intermolecular asymmetric carbon-hydrogen bond activation reaction on a 3-aryl indazole biaryl compound and disubstituted alkyne, and after the reaction is finished, separating to obtain the chiral diazaspirene-containing compound, according to the invention, synthesis of the chiral helicene compound is realized through a transition metal catalysis asymmetric carbon-hydrogen bond activation method, the research technology of Cp metal catalysis asymmetric carbon-hydrogen bond activation is further developed, and the synthesis strategy of the chiral helicene compound is expanded at the same time; reaction substrates are wide in universality, and chiral control in the reaction process is realized through the chiral cyano phosphine oxide, so that the product has very high enantioselectivity; various chiral helicene compounds are synthesized, the synthesis method is simple and convenient, and the atom economy is high.

This invention relates to the field of organic synthetic chemistry, specifically to a polysubstituted furan compound and its synthetic method, wherein the method comprises... β Using ketone sulfones and olefins as starting materials, polysubstituted furans are synthesized via a [3+2] cycloaddition reaction in the presence of a copper catalyst and an oxidant. This invention employs cuprous bromide as the catalyst and di-tert-butyl peroxide (DTBP) as the oxidant, reacting in dimethyl sulfoxide solvent at 100°C–130°C for 6–24 h. This method offers advantages such as high atom and step economy, broad substrate applicability, good functional group tolerance, excellent position selectivity, and high yield, with a maximum yield reaching 84%. It is suitable for large-scale synthesis and provides a new strategy for the synthesis of furans in medicinal chemistry and materials science.

The invention discloses a preparation method of an intermediate of macloxvir. The preparation method comprises the following steps: step 1, carrying out halogenation reaction; step 2, elimination reaction; step 3, addition reaction; step 4, ring closing reaction; the starting raw materials, the solvent and the catalyst selected in the invention are industrial-grade cheap and easily available products, have the advantage of low production raw material cost, and provide economic feasibility support for industrial large-scale production; reaction conditions of each step in the reaction process are mild, byproducts are few, the yield is high, and a target product can be prepared more efficiently; meanwhile, the synthesis route is high in atom utilization rate and excellent in atom economy, the used solvent and reagent are high in stability and easy to recycle and reuse, generation and emission of industrial three wastes are greatly reduced, the environment-friendly treatment cost is reduced, and the concept of green chemistry and sustainable development is met; the method gives consideration to economy, high efficiency and environmental friendliness, and solves the problems of low yield, violent reaction conditions and high cost of raw materials and auxiliary materials in the existing method.

This invention relates to the field of chemical synthesis technology, specifically disclosing a method for preparing vinyl ethylene carbonate. The method uses glycidyl as a starting material, first converting it to glycidaldehyde via a mild oxidation reaction with high selectivity. Then, using a cross-linked imidazole polymeric ionic liquid as a catalyst, glycidaldehyde undergoes an atom-economical cycloaddition reaction with carbon dioxide to construct a cyclic carbonate intermediate. Finally, under catalytic conditions, a condensation reaction introduces a vinyl functional group to obtain the vinyl ethylene carbonate product. This invention uses widely available, low-toxicity, and inexpensive glycidyl instead of highly toxic raw materials, and utilizes greenhouse gas carbon dioxide as a carbonyl source for resource utilization. The process route is highly atom-economical, the reaction conditions are mild, and the catalyst is easy to separate, recover, and recycle, effectively solving the prominent problems of high raw material toxicity, expensive catalysts, and difficult byproduct treatment in traditional preparation techniques.

The application belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 2-aryl-2-cyclohexanedione enol ester compounds. The method uses a transition metal complex as a catalyst, and uses a phenyl boronic acid compound and an iodine onium compound as raw materials, first synthesizes a 3-hydroxy-2-aryl-2-cyclohexenone compound, and then synthesizes the 2-aryl-2-cyclohexanedione enol ester compound through acylation. The reaction condition is mild, no additional additives (such as alkali-sodium acetate, expensive silver salt-silver acetate, etc.) need to be added, the C-C bond can be efficiently and quickly constructed, the 2-aryl-2-cyclohexanedione cyclization derivative is obtained, the reaction operation is simple, the reaction time is short, the method has high efficiency and high safety, the substrate range is wide, the functional group tolerance is good, the method conforms to the concept of green chemistry and high atomic economy, and is very suitable for large-scale industrial production.

The application discloses a preparation method of a non-conjugated functionalized olefin compound, and the method is carried out in a cobalt / photocatalysis dual catalytic system which is composed of a cobalt catalyst, a ligand, a photocatalyst, a hydrogen source, a base and a solvent. β The target product is efficiently and selectively synthesized through reaction of an ethylenic compound or a halogenated compound or an electron-deficient olefin represented by formula (2) with acetylene as a C2 synthetic unit. The application adopts a cobalt / photocatalysis dual catalytic synergistic mechanism, has mild conditions (normal temperature and pressure, visible light driving), uses water as a green hydrogen source, uses acetylene as a cheap C2 source, has high atom economy, has good substrate universality, and the compound represented by formula (1) is easy to be prepared through Friedel-Crafts acylation or is commercially available, and the compound represented by formula (1) is easy to generate the compound (III) represented by formula (2) under the action of a base. The obtained non-conjugated olefin is a key intermediate for synthesizing high-value-added fine chemicals such as fragrances and insect pheromones, and has wide application prospects.

The invention discloses a high-efficiency transfer hydrogenation method of non-activated olefin, which comprises the following steps: adding a non-activated alkenyl amide compound, nickel acetylacetonate dihydrate, phenylsilane, water and cesium pivalate into an organic solvent 1, 4-dioxane, reacting at room temperature under a nitrogen condition for 12 hours, and after the reaction is completed, filtering to obtain a filtrate, namely the high-efficiency transfer hydrogenation method of the non-activated olefin. And performing post-treatment (extraction and column chromatography separation) to obtain the corresponding alkyl chloride compound. According to the method, phenylsilane and water are directly used as hydrogen sources, direct use of hydrogen can be avoided, operation is easy and convenient, and efficient construction of C (sp3)-C (sp3) bonds can be achieved through transfer hydrogenation of non-activated olefin. The conversion reaction conditions are extremely mild, and the reaction activity is high; the method has the advantages of excellent atom economy and step economy, wide substrate application range, good functional group compatibility and the like. It is worthy that the synthesis method is also suitable for later-stage modification of medicine molecules, and the druggability of the molecules is expected to be further improved.

The invention discloses a method for co-production of 2, 4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride, and belongs to the technical field of organic chemical industry, 2, 4-dichlorofluorobenzene is used as a raw material, alkylation and reaction with tert-butyl nitrite are performed to generate oxime, and then hydrochloric acid hydrolysis is performed to generate 2, 4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride; according to the method, co-production of the 2, 4-dichloro-5-fluoroacetophenone and the hydroxylamine hydrochloride is innovatively realized, not only are high yield and high purity of the target product 2, 4-dichloro-5-fluoroacetophenone ensured, but also the nitrogen element in the reaction is recycled and converted into the hydroxylamine hydrochloride with high additional value, and the atom economy is remarkably improved; according to the method, the operation process is greatly simplified, the use of dangerous reagents is avoided, and the intrinsic safety and environmental friendliness of the process are improved from the source; the method is simple to operate, safe and environment-friendly, the production cost is effectively reduced, and the market competitiveness of the product is enhanced.

The invention provides a method for preparing Etelcalcetide through solid-liquid combination, which comprises the following steps: (1) carrying out amino acid coupling reaction on solid-phase carrier resin, Fmoc-D-Arg-OH, Fmoc-D-Ala-OH and Fmoc-D-Cys (Trt)-OH under the action of a dehydrating agent and a polypeptide condensing agent by adopting a solid-phase synthesis method to prepare peptide resin; (2) cracking the peptide resin and a side chain protecting group by virtue of a cracking solution, and adding 2, 2-dithiobipyridine to activate a side chain sulfydryl to obtain an activated intermediate; (3) constructing a disulfide bond from the activated intermediate in a solvent by adopting a liquid phase synthesis method, so as to prepare an Etelcalcetide crude product; and (4) purifying the crude product of the Etelcalcetide, so as to obtain the Etelcalcetide. The D-Arg amino acid which is low in price and unprotected in side chain is used, so that the method has relatively high atom economy.

The invention discloses a method for preparing fatty tertiary amine with large steric hindrance without an external hydrogen source, and the specific implementation process is as follows: taking a compound A and a compound B as raw materials, and efficiently synthesizing a compound C through a hydrogen borrowing and reducing process of a copper-manganese bimetallic catalyst in a nitrogen atmosphere. The catalyst is prepared by adopting a step-by-step impregnation method: firstly, loading a manganese precursor on a carrier, and drying and roasting to form a manganese species which has the function of pre-adsorbing and fixing large-steric-hindrance amine molecules so as to effectively reduce steric hindrance; and then a copper precursor is loaded, and a manganese auxiliary agent promotes high dispersion of a copper active center, so that a C-OH bond of alcohol is efficiently activated. The method is mild in reaction condition, only water serves as a byproduct, the defects that high-risk reagents and high-temperature and high-pressure hydrogen sources are used and waste is generated in a traditional method are overcome, and the method has the advantages of being high in selectivity, good in atom economy, environmentally friendly, safe and the like and is suitable for large-scale production of drug intermediates and functional chemicals.

The invention relates to the technical field of organic synthesis chemistry and catalytic chemistry, and discloses a reaction method for obtaining a biaryl compound through Suzuki-Miyaura coupling based on C-S bond activation, aryl sulfide is used as an electrophilic reagent, aryl boric acid ester is used as a nucleophilic reagent, in the presence of a nickel catalyst, a bidentate ligand, alkali and copper salt, a reaction is performed in an organic solvent, and the biaryl compound is obtained. Thus, the corresponding biaryl compound is obtained. According to the method, traditional C-S bonds difficult to break can be efficiently activated under uniform conditions, electron-rich and electron-deficient aryl thioethers and various aryl borates are compatible, and the application range of a substrate is wide; meanwhile, the aryl sulfide does not need to be pre-oxidized or pre-functionalized, the steps are simple, the atom economy is high, and the method is suitable for large-scale production. The obtained biaryl compound can be widely applied to the fields of drug molecule synthesis, organic semiconductor materials and the like.

The invention relates to a metal hydroxide for a heat storage system and a green preparation method and application thereof. The green preparation method of the metal hydroxide, provided by the invention, comprises the following steps: dissolving metal acetate in water, and preparing a metal acetate aqueous solution with the metal ion concentration of 0.01-1mol / L; placing the metal acetate aqueous solution in an open container, and carrying out evaporation concentration treatment at 30-95 DEG C for 1-96 hours to generate a metal hydroxide precipitate; and carrying out solid-liquid separation on the metal hydroxide precipitate, washing and drying to obtain the metal hydroxide. The method does not need to add an alkaline agent or an organic auxiliary agent, avoids generation of by-products of salts and high-salt waste liquid, and accords with 12 principles of green chemistry; reaction conditions are mild, the process is simple, operation can be carried out at normal temperature and normal pressure, energy consumption is low, and safety is high; the raw material conversion rate is high, mother liquor can be recycled, and high-atom-economy and low-cost production is achieved.

The invention provides an L-threonine aldolase mutant, the amino acid sequence of the L-threonine aldolase mutant is obtained by mutating wild type L-threonine aldolase as shown in SEQ ID NO.1, and the mutations comprise at least one mutation of amino acids at the 185th site, the 198th site, the 281 site, the 8th site, the 142 site and the 171th site of the SEQ ID NO.1. The invention also provides an application of the mutant as a catalyst in synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-methylsulfonyl phenyl) propionic acid. Compared with other biocatalysts, the L-threonine aldolase mutant disclosed by the invention is high in catalytic activity and high in yield, meets the requirement that the de value is as high as 99%, has the advantages of high atom economy, high product optical purity, mild reaction conditions, environment friendliness, simple product post-treatment and the like, and is a (2S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S, 3S The method is one of the most ideal reactions for synthesizing (3R, 3R)-2-amino-3-hydroxy-3-(4-methylsulfonyl phenyl) propionic acid.

The application discloses a hexaazaisowurtzitane derivative and a preparation method and a synthesis method of HNIW, and belongs to the technical field of chemical synthesis.The preparation method of the hexaazaisowurtzitane derivative has the advantages of short reaction steps, simple operation, easily available raw materials and industrial application potential.The hexaazaisowurtzitane derivative can be used to synthesize hexanitrohexaazaisowurtzitane (HNIW) through nitration, so that the synthesis process is simplified and the production cost is reduced; the leaving group cyclopropyl accounts for a small proportion of the cyclopropylamine raw material, has good atom economy, has high raw material utilization, reduces waste emission and meets the environmental protection concept of green economy.

This invention discloses the preparation of a high-efficiency paraformaldehyde sulfonic acid catalyst and its application in the catalytic synthesis of C14 secondary alcohols, relating to the field of olefin catalytic hydration technology. The catalyst is prepared by high-temperature polymerization of p-toluenesulfonic acid and paraformaldehyde under concentrated sulfuric acid catalysis. C14 olefins, the paraformaldehyde sulfonic acid catalyst, isopropanol, and deionized water are added to a reactor, and a catalytic reaction is carried out at a certain temperature. The product conversion rate is 0.46%, and the selectivity is >99%. The catalyst of this invention is simple to prepare, has a well-developed mesoporous structure and sufficient acidic sites, provides mild catalytic hydration reaction conditions, exhibits good olefin conversion and secondary alcohol selectivity, and is easily recoverable and reusable. The process is green and environmentally friendly, with high atom economy, and is beneficial for the industrial conversion and application of high-value utilization of Fischer-Tropsch olefins from coal-to-oil.

The application discloses a synthesis method of 2-aryl-4-phosphoryl-4H-chromene compounds, which comprises the following steps: dissolving 2-hydroxychalcone, diaryl phosphine oxide and mercury triflate in an organic solvent, and reacting at 80-100 DEG C; after the reaction is completed, 2-aryl-4-phosphoryl-4H-chromene compounds are obtained through separation and purification; the synthesis method is simple, the reaction condition is mild, and the operation is convenient; the raw materials are easy to prepare; the reaction byproduct is water; and the method has the advantages of high atomic economy, green environmental protection and the like.

The application discloses tetraacetyldicyclopropylhexaazaisowurtzitane and a preparation method thereof, and a synthesis method of HNIW, and belongs to the technical field of chemical synthesis. The tetraacetyldicyclopropylhexaazaisowurtzitane is a new hexaazaisowurtzitane derivative, the preparation method has short reaction steps, simple operation, and raw materials are easy to obtain, and has industrial application potential. The tetraacetyldicyclopropylhexaazaisowurtzitane can be used for synthesizing hexanitrohexaazaisowurtzitane (HNIW) through nitration, the synthesis process is simplified, and the production cost is reduced; the leaving group cyclopropyl has a small proportion in the cyclopropylamine raw material, has good atom economy, has high raw material utilization, reduces waste emission, and meets the environmental protection concept of green economy.

The invention belongs to the technical field of electrochemical synthesis and isotope labeling, and particularly discloses a method for preparing a deuterated compound through electrochemical coupling and a special catalyst thereof. According to the invention, a carbon-hydrogen bond halogenation-dehalogenation deuteration process is coupled, a specific noble metal nitrogen-doped carbon catalyst is screened and applied as a cathode and anode catalytic material, a brand new electrochemical system is constructed for the first time, and under the environment-friendly reaction conditions of completely no solvent and no supporting electrolyte, through electrochemical driving, the electrochemical performance of the electrochemical system is improved. The selective halogenation of carbon-hydrogen bonds of the anode and the dehalogenation deuteration reaction of the cathode are synchronously realized, the two half reactions are successfully and efficiently coupled in the same reactor, and the deuterated organic compound with high additional value is directly synthesized. According to the method, a large amount of organic solvents and electrolyte salts used in traditional organic synthesis are abandoned, the environmental load and post-treatment difficulty of the reaction are remarkably reduced, and the method has the outstanding advantages of being simple in process, environmentally friendly and high in atom economy.

This invention discloses a dual-enzyme system for catalyzing the synthesis of L-cysteine ​​from D-serine and its applications. This dual-enzyme system achieves the asymmetric synthesis of L-cysteine ​​from D-serine with a substrate conversion rate of 99% and a product yield >110%. The catalytic process of this invention is simple, with no byproducts generated and easy subsequent separation. Therefore, it has advantages such as high atom economy, high product optical purity, mild reaction conditions, environmental friendliness, and simple product post-processing. It has great potential for the industrialization of low-cost and controllable multi-enzyme preparation of L-cysteine.

This invention discloses a method for synthesizing a tenapano hydrochloride intermediate. The synthesis method includes the following steps: (1) condensing the compound 3-bromophenylacetaldehyde and the compound N-methyl-(2,4-dichlorophenyl)methylamine under dehydration conditions to obtain an enamine intermediate; (2) subjecting the enamine intermediate to an intramolecular cyclization reaction in the presence of an acid catalyst to obtain the tenapano hydrochloride intermediate 4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline. The synthetic route provided by this invention requires only two steps to construct the key framework, and has the advantages of short reaction steps, high overall yield, and no need to use highly toxic liquid bromine. This process has high atom economy, reduces the emission of waste gas, wastewater, and solid waste, and is suitable for large-scale industrial production under mild conditions.

The application discloses a kind of 1,2-naphthalene dicarboxylic acid diethyl compound photocatalytic synthesis method, it includes the following steps: styrene compound, alpha-diazo iodonium salt and catalyst are dispersed in organic solvent, then coupling cyclization reaction is carried out under light, obtains 1,2-naphthalene dicarboxylic acid diethyl compound.The 1,2-naphthalene dicarboxylic acid diethyl compound photocatalytic synthesis method of the application has the advantages that raw material is cheap and easy to obtain, simple and efficient, reaction condition is mild, atom economy is high, product is easy to purify, production cost is low, green and safe, suitable for large-scale industrial production.