101 results about "Dimethylurea" patented technology

Highly concentrated, water-based dispersions of certain lipophilic and/or hydrophobic antimicrobially active materials are stabilized to a surprising degree by a surfactant combination including a nonionic acrylic graft copolymer surfactant and a alkoxylated polyarylphenol phosphate ester surfactant. The active materials may be present in dispersion concentrates of the present invention singly or in useful combinations. The active materials are selected from the group of fungicides and bactericides consisting of 1,2-benzisothiazol-3(2H)-one; 2-octyl-2H-isothiazol-3-one; 5-chloro-2-methyl-2H-isothiazol-3 -one; 2-methyl-2H-isothiazol-3-one; pyrithione zinc; 3-iodo-2-propynyl butylcarbamate; 2-methylthio-4-ethylamino-6-tert-butylamino-s-triazine; and 3-(4-isopropylphenyl)-1,1-dimethylurea, and mixtures thereof. The dispersion concentrates may be efficiently shipped and stored, and subsequently diluted with water to produce less concentrated dispersions when desired. Even at relatively high concentrations, the dispersion compositions of the present invention can be stored for months or years without significant loss of stability.

The invention relates to an anti-wrinkle tidying method for a pure cotton fabric, sequentially comprising the following processes: shell fabric preparation, pre-limbering, resin padding, curing, rinsing, post-limbering and preshrinking. The method has the main technical characteristic that the padding formula used in the resin padding process comprises the following components by concentration: 80-120g/L of 2D resin, 80-100g/L of oxalaldehyde resin, 40g/L of 1,3-Dimethylurea, 40g/L of magnesium chloride activated by organic acid, 20-40g/L of brute-force protective agent, 1-2g/L of penetrating agent and the balance of water. The invention has reasonable design, and fully utilizes the advantages of two types of the resins and catalysts; the tidied pure cotton fabric has the characteristics of higher planeness, higher brute force, favorable abrasive resistance, lower formaldehyde content and the like; and the garment made of the tidied pure cotton fabric has the characteristics of comfortable wearing, beautiful appearance and strong durability.

The invention discloses a 3-cyclohexyl-1,1-dimethylurea compound as well as a preparation method and application thereof. The 3-cyclohexyl-1,1-dimethylurea compound is used for preparing an antischizophrenic drug cariprazine. Compared with the prior art and report literatures, the preparation method of the 3-cyclohexyl-1,1-dimethylurea compound has the remarkable advantages of being free of removal of protecting groups such as Boc group, high in atom economy, low in cost and easy in getting of raw materials, mild in reaction condition, stable in yield, simple and convenient to operate, controllable in product quality, high in product purity, less in three waste pollution and easy to produce industrially. The structure formula of the 3-cyclohexyl-1,1-dimethylurea compound is as shown in (I) in the specification.

An epoxy resin composition comprising the following Component (A), Component (B), Component (C), and Component (D): Component (A): an organic phosphinic acid metal salt; Component (B): an epoxy resin; Component (C): dicyandiamide or a derivative thereof; and Component (D): a curing accelerator having a dimethylureido group. The epoxy resin composition described above, further comprising the Component (E) which is an imidazole-based curing accelerator having a curing initiation temperature of 100° C. or higher as measured by the following method. Measurement method of a curing initiation temperature: a sample resin composition is prepared by adding 10 parts by mass of an imidazole-based curing accelerator to 100 parts by mass of a bisphenol A type epoxy resin having an epoxy equivalent of 180 to 220, and mixing the components. For this sample resin composition, the calorific value is measured using a differential scanning calorimeter (DSC) at a rate of temperature increase of 10° C./min, and the temperature at the intersection point of the tangent line at the inflection point of the DSC curve thus obtained and the baseline is designated as the curing initiation temperature.

A blood cell analyzer diluent and a hemolytic agent, are characterized in that one litre diluent is provided with 12.0-4.0g of sodium chloride, 2.0-10.0g of sodium sulfate, 0.8-0.5g of 1,3,2-methylol urea, 0.2-0.5g of copper sulfite, 3.0-8.0g of EDTA-2Na, 0.2-0.7g of Piperacillin Sodium, a borate buffering liquid toning the ph value to 7.2-7.8, and the balance is water; one litre hemolytic agent is provided with 0.8-5.0g of potassium chloride, 0-60.0g of dodecyl trimethyl ammonium chloride, 14.0-0g of octadecyl trimethyl ammonium bromide, 6.0-10.0ml of isopropanol, carbonate or alcaine buffering liquid toning the ph value to 7.2-7.8, and the balance is water. The inventive reagent can form stable hemoglobin derivatives, and the absorption spectrum curves are similar when lambada is 540nm, lambada is 504nm, which can satisfy the clinical inspection requirement; the reagent does not contain cyanide, azide, and has non-toxicity, which can effective improve working atmosphere of operating staff, and can reduce harm of toxicant to personal health.

The invention discloses a marine modified silicone-acrylic resin antifouling antibacterial coating. Raw materials of the coating comprise modified silicone-acrylic resin, chlorosulfonated polyethylene, teflon, a vinylidene fluoride-hexafluoropropene copolymer, nano-silver, carbon nanotube, carbon fiber, nano-sized iron oxide, nano-zinc oxide, kaolin, lanthana, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, PTPB, 4,5-dichloro-2-n-octyl-3-isothiazolinone, trimethyl silicone oil, a coalescing agent, a dispersant, an antifoaming agent, a corrosion inhibitor, a leveling agent and a thickening agent. The marine modified silicone-acrylic resin antifouling antibacterial coating has high hardness and good antifouling property and antibacterial property, and has an effect of inhibiting adhesion of multiple marine organisms when in use.

The invention provides a preparation method for an artificial antigen of theophylline. The preparation method comprises the following steps of: (a) preparing and detecting a hapten: reacting 5,6-diamido-1,3-dimethylurea pyrimidine (1) with glutaric anhydride to obtain the hapten containing carboxyl; (b) preparing and detecting the artificial antigen: combining the hapten with bovine serum albumin (BSA) by utilizing a carbodiimide method, so as to prepare the artificial antigen of the theophylline, namely theophylline-bovine serum albumin. According to the preparation method, the prepared artificial antigen of the theophylline can be subjected to animal immunization to obtain corresponding theophylline antibodies and can be used for researching various theophylline immunoassay methods, and a relatively convenient, fast and accurate way is provided for the detection of the theophylline.

The invention discloses a preparation method of 6-amino-1,3-dimethyluracil. According to the preparation method, cyanoacetic acid and 1,3-dimethylurea undergo condensation under the action of acetic anhydride so as to obtain 2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide; and then 2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide undergoes a cyclization reaction under an alkaline conditionso as to obtain 6-amino-1,3-dimethyluracil. The 6-amino-1,3-dimethyluracil has a good system stabilizing effect when used as a main component of a PVC stabilizer along with zinc stearate, and has a better synergistic effect than a commonly-used counterpart in the industry at present. The 6-amino-1,3-dimethyluracil can absorb HCl and also can replace unstable chlorine atoms. On the other hand, the6-amino-1,3-dimethyluracil also can react with ZnCl2 to generate a metal complex and inactivate ZnCl2. Thus, long-term stability of a PVC sample is greatly enhanced.

The invention belongs to the technical field of macromolecule degradation and catalysis, and relates to a preparation method of a low-eutectic solvent catalyst and application thereof to the PET alcoholysis process. Urea compounds 1,3-dimethylurea, trimethyl-urea and 1,1 dimethylurea are used as hydrogen bond donors of a low-eutectic solvent to perform complexation reaction with inorganic zinc salts and inorganic manganese salts; a metal compounding low-eutectic solvent is formed; the low-eutectic solvent can be used as catalysts to be applied to PET alcoholysis reaction; the advantages of high catalysis activity and high reaction speed are realized; the potential application prospects are realized.

The invention provides a preparation method of 6-chloro-1,3-dimethyluracil, which comprises the following steps: carry out reflux reaction on 1,3-dimethylbarbituric acid and a chlorinating agent in a water-insoluble organic solvent to obtain a reaction mixture; and adding water to quench the reaction to obtain the 6-chloro-1,3-dimethyluracil, wherein the chlorinating agent comprises phosphorus oxychloride. The preparation method provided by the invention reduces the consumption of phosphorus oxychloride, and does not need to perform vacuum distillation on the phosphorus oxychloride. Furthermore, additives can be added in the reaction process to enhance the yield of the 6-chloro-1,3-dimethyluracil. The invention also provides a method for synthesizing 1,3-dimethylbarbituric acid, which is implemented by reacting 1,3-dimethylurea, dimethyl malonate and a condensing agent in an organic solvent. The method avoids using abundant malonic acid and acetic anhydride.

The invention belongs to the technical field of organic synthesis, and provides a novel method for synthesizing cariprazine. The novel method comprises the following steps: firstly, carrying out condensation reaction on trans-2-(4-(3,3-dimethyl ureido) cyclohexyl) acetic acid and 1-(2,3-dichlorophenyl) piperazine to obtain 3-(trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-2-oxo-ethyl}-cyclohexyl)-1,1-dimethylurea; and secondly, reducing 3-(trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-2-oxo-ethyl}-cyclohexyl)-1,1-dimethylurea by using borane to obtain the cariprazine. The method hasthe advantages that process steps are greatly shortened, the purity of a final product is ensured and the total yield is obviously increased.

To provide an epoxy-resin composition and prepreg for producing a fiber-reinforced composite material which exhibits excellent curability and has excellent flame retardance and heat resistance, as well as to provide fiber-reinforced composite materials produced using the prepreg and to provide housing for electronic/electrical devices. The epoxy resin composition contains component (A): a phosphorus compound; component (B): an epoxy resin which has at least three epoxy groups in the molecule, and which does not correspond to component (A) nor include component (A); component (C): an epoxy resin curing agent which does not have a urea structure in the molecule; and component (D): a dimethylurea compound represented by formula (a) (in formula (a), “R” is a hydrogen atom or an alkyl group having any number of 1 to 10 carbons).

The invention discloses a production system and a production method for preparing 6-amino-1, 3-dimethyluracil. According to the method, a methyl cyanoacetyl urea solution and caustic soda liquid are used as raw materials, the methyl cyanoacetyl urea solution and the caustic soda liquid are input into an impinging stream reactor at a certain speed and are in rapid contact and fully mixed in the reactor, then the mixture enters a reaction kettle, the temperature of the reaction kettle is controlled to be 50-150 DEG C, the reaction kettle is provided with an online pH meter, the pH value is controlled according to the end point, and caustic soda liquid is supplemented; the method comprises the following steps: reacting a dimethyl cyano acetylurea solution with liquid caustic soda in a reaction kettle to generate 6-amino-1, 3-dimethyluracil slurry, and carrying out centrifugal separation to obtain the product 6-amino-1, 3-dimethyluracil. In the reaction process, the 6-amino-1, 3-dimethyluracil is prepared through impinging stream atomization reaction, and the particle size distribution can be controlled. According to the invention, the caustic soda liquid and the dimethyl cyanoacetylurea solution are continuously fed, and the two solutions are rapidly and uniformly mixed in the impinging stream mixer, so that the reaction efficiency is improved, and good economic efficiency can be obtained.

The invention discloses a method to prepare 1, 3-dimethyl barbituric acid through the reaction of malonic ester and 1, 3-dimethylurea. The method adopts sodium alcoholate as catalyst and lower aliphatic alcohol or the mixture of the lower aliphatic alcohol and phene, toluene or dimethyl benzene as solvent, wherein, the catalyst and the solvent are blended in a reactor to a raised temperature of 60-120 DEG C and done with reflux reaction for 9-10 hours; after the completion of the reaction, the reacted product is cooled to precipitate solid which is then filtered and then dissolved in water; then the pH of the solution is adjusted to 1-2 by adding hydrochloric acid and cooled to precipitate crystal, which is filtered again and crystallized again to obtain the 1, 3-dimethyl barbituric acid. The invention has low-cost raw materials, simple operation and high product yield.

The invention discloses a synthetic method of high-purity high-yield theophylline. The synthetic method comprises the following steps: preparing 6-amino-5-bromo-1,3-dimethyl uracil by adopting sodium acetate trihydrate, 6-amino-1,3-dimethyl uracil, anhydrous acetic acid and liquid bromine; preparing 6-amino-5-benzylamino-1,3-dimethyl uracil by adopting 6-amino-5-bromo-1,3-dimethyl uracil and benzylamine; preparing 1,3-dimethyl-7-benzyl xanthene by adopting 6-amino-5-benzylamino-1,3-dimethyl uracil, p-toluene sulfonic acid, triethyl orthoformate and DMF (dimethyl formamide); and preparing theophylline from 1,3-dimethyl-7-benzyl xanthene, a palladium carbon catalyst and methanol in a hydrogen high-pressure environment. According to the synthetic method disclosed by the invention, the reaction starting material is simple and easy to obtain, the used reagents are safe and environment-friendly, the production cost is greatly reduced, and the preparation process is simple and easy to operate; and compared with the prior art, the reaction environment related to each step is small in pollution, and the yield and purity of obtained theophylline are greatly improved.

The invention relates to the technical field of pest prevention and control, particularly relates to a medicine for preventing and controlling water lettuce, and also relates to a preparation method and an application method thereof. An efficient environment-friendly water lettuce prevention and control medicine consists of the following components in percentage by weight: 30-40% of N-(3,4-dichlorophenyl)-N',N'-dimethylurea, 25-35% of N-(phosphonomethyl) glycine, 20-30% of aluminum potassium sulfate dodecahydrate, 0.2-5% of nonionic surfactant and 0.2-5% of vegetable oil. Through the invention, an effect of upper control and lower curing can be realized; 24 days later, the leaves and root tips of the water lettuce thoroughly die and are dissolved, the death rate reaches 100%, and regeneration is avoided; and moreover, the medicine is nontoxic and harmless and environment-free, and prevents influence on the organisms of water bodies (aquatic fish and poultry) as well as secondary pollution.

Method of single step electrochemical generation of chlorinated urea, chlorinated dimethylurea and other chlorourea derivatives is disclosed. The chlorinated species are generated in situ and upon demand and can be used for microbial control in industrial water treatment.

The present invention relates to trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N′,N′-dimethylurea (cariprazine), its salts, close analogs, derivatives, pharmaceutical compositions, metabolites and combinations for use in the treatment of symptoms of autism spectrum disorder in general, and preferably the object of the present invention is to treat one or more symptoms of autism.

Furthermore, it was also found that cariprazine, its salts, close analogs, derivatives, pharmaceutical compositions, metabolites and combinations are suitable for treatment of conditions such as Asperger's syndrome, atypical autism (otherwise known as pervasive developmental disorder not otherwise specified; PDD-NOS), Rett syndrome, childhood disintegrative disorder, attention deficit hyperactivity disorder (ADHD) and sensory integration dysfunction.

The invention discloses an antifouling water-based latex coating, which is prepared from acrylic ester copolymer emulsion, an extender pigment, a pigment dispersing agent, an antifouling agent, and an mildew preventive and a preservative through taking water as a dispersing medium, wherein the extender pigment is titanium dioxide, the pigment dispersing agent is sodium dodecyl benzene sulfonate, the antifouling agent is 3-(3,4-dichlorophenyl)-1,1-dimethylurea, the mildew preventive is 8-hydroxyquinolinato copper, and the preservative is ethyl p-hydroxybenzoate. The antifouling water-based latex coating is prepared from the acrylic ester copolymer emulsion, the extender pigment, the pigment dispersing agent, the antifouling agent and the mildew preventive, thus having the characteristics of being low in cost, stable in quality, good in antifouling property, mildew-proof, good in corrosion resistance, and long in storage time.

The invention relates to synthesis of N-methylmethyl carbamate, which comprises the following steps: adding dimethyl carbonate and 1,3-dimethylurea in a mol ratio of (15-1):1 and a catalyst into a stainless steel reaction kettle, wherein the catalyst accounts for 1-12 mol% of the raw material 1,3-dimethylurea; and reacting in the closed reaction kettle at 80-200 DEG C under the reaction pressure of 0.1-5.0 MPa for 0.5-10 hours to obtain the N-methylmethyl carbamate. The method has the advantages of mild reaction conditions and simple process, and is easy to operate; and the generated MMC is high in yield and easy to separate.

The invention discloses an environment-friendly phase-change heat storage energy-saving brick and a preparation method thereof, which relate to the technical field of energy-saving bricks. The energy-saving brick is prepared from the following materials: waste polished tile residue powder, modified porous basalt, Xinjiang Qieganbulake vermiculite tailings, attapulgite clay, expanded perlite, silicon nitride fiber, calcium chloride, trimethylolpropane, cationic polyacrylamide, phenyl salicylate, sodium tripolyphosphate, 1,3-dimethylurea, a calcium sulphoaluminate expanding agent, a foaming agent, a foam stabilizer and a coupling agent. According to the preparation, the environment-friendly phase-change heat storage energy-saving brick is prepared by material mixing, shaping and curing. Theenergy-saving brick disclosed by the invention is easy and convenient to prepare, the cost is low, the energy-saving brick has excellent mechanical property, flame-retardant and thermal insulation properties, corrosion and weathering resistance, waterproof and anti-freezing properties and the like, application fields are wide, and the energy-saving brick is safe and reliable.

The invention provides an antibacterial and anti-wrinkle fabric care agent. The care agent comprises the following components in parts by weight: 5-8 parts of polyoxyethylene ether, 3-5 parts of dimethylurea, 3-5 parts of sodium polyacrylate, 2-3 parts of hydroxyethyl cellulose, 3-5 parts of sodium alkyl benzene sulfonate, 1-2 parts of urea, 1-2 parts of potassium nitrate, 0.3-0.5 part of potassium oxalate, 0.2-0.3 part of sodium alginate, 3-5 parts of ethanol and 50-60 parts of water. The invention also provides a preparation method of the care agent. The antibacterial and anti-wrinkle fabric care agent has the beneficial effects that the care agent has good inhibitory effects on various bacteria and has an antibacterial rate higher than 70% especially on Escherichia coli and staphylococcus aureus; the antibacterial rate is still maintained at a higher level after washing 40 times and is above 65%; meanwhile, the care agent has a good anti-wrinkle property; the dry and wet wrinkle recovery angles of the fabric treated with the antibacterial and anti-wrinkle fabric care agent are increased by more than 30%; the wrinkle recovery angle is basically invariable after soaping 40 times.

The invention discloses an organic fertilizer for increasing the yield of eggplants. The organic fertilizer comprises the following materials in parts by weight: 40-50 parts of wheat straws, 13-16 parts of chicken manure, 12-16 parts of castor cake, 5-7 parts of fern root residues, 4-6 parts of clam shells, 6-10 parts of kelps, 10-15 parts of fructus ulmns pumila, 3-4 parts of an EM fungicide, 9-11 parts of lychee exocarp, 4-8 parts of coriaria sinica root, 2-5 parts of grass nodes in the stomach of ox and goat, 1-3 parts of N,N-dimethylurea, 1-3.8 parts of lentinan polysaccharide, 1-5 parts of fulvic acid, 2-5 parts of lime nitrogen, 0.1-0.5 parts of salicylic acid, 3-5 parts of potassium dihydrogen phosphate, 3-5 parts of potassium sulfate, 3-5 parts of ammonium dihydrogen phosphate, 3-5parts of diammonium phosphate, 2-4 parts of amino acid, 2-4 parts of humic acid, 2-4 parts of alginic acid and 2-4 parts of chitin. The organic fertilizer disclosed by the invention has the advantages that various nutritional elements can be provided for the growth of the eggplants, the growth of the plants can be stimulated, the permeability of soil can be improved, the metabolism can be promoted, the occurrence of disease and insect damage can be relieved and prevented; and due to photosynthetic bacterium fertilizer contained in a formula, the digestion and absorption of the eggplants for the chemical fertilizer can be promoted and the fertilizer utilization rate can be increased.

The invention discloses a synthesis method of 3-(3-hydroxyphenyl)-1, 1-dimethylurea, an intermediate and application. The synthesis method comprises the steps of: generating 3-trimethylsiloxy phenylamine from m-aminophenol as a raw material under the catalysis of HDMS and phosphotungstic acid, then reacting with dimethylamino formyl chloride to obtain 1, 1,-dimethyl-3-(3-trimethylsiloxy phenyl) urea, and then removing TMS to obtain 3-(3-hydroxyphenyl)-1, 1-dimethylurea. The method has the advantages of simple synthesis route, simplicity in operation, high yield and no pollution.