88 results about "Molecular recognition" patented technology

The invention discloses a hollow covalent organic framework fiber separation membrane with a molecular recognition function and a preparation method and application thereof.The method comprises the steps that polylactic acid and aldehyde monomers are added into a solvent A, and an aldehyde-loaded spinning solution is prepared; spinning the aldehyde-loaded spinning solution to obtain an aldehyde fiber precursor membrane; taking the formylated fiber precursor membrane as a template, immersing the formylated fiber precursor membrane into a reaction system consisting of an amino monomer, a catalyst and a solvent B, and initiating dynamic covalent assembly to prepare a COF shell-coated fiber membrane; immersing the fiber membrane coated with the COF shell layer into a solvent C to remove the polylactic acid template so as to prepare hollow COF fibers; and immersing the hollow COF fiber into a solvent system containing a gas recognition functional monomer, and constructing a gas molecule recognition layer on the surface of the hollow COF fiber to prepare the hollow COF fiber separation membrane. According to the application, the hollow covalent organic framework fiber separation membrane is applied to precise recognition operation of sulfur-containing gas. According to the invention, an efficient and energy-saving innovative membrane material with resource enrichment potential can be prepared.

The invention relates to the technical field of metal organic framework materials (MOF) and isotope separation, in particular to a functionalized metal organic framework material for water / heavy water separation and a preparation method and application thereof. The metal organic framework material is a porous crystal material which is formed by coordination self-assembly of metal ions and V-shaped organic ligands and has a periodic network structure; the V-shaped organic ligand is a V-shaped dicarboxylic acid organic ligand modified by an oxygen-containing functional group designed through topological functionalization. According to the metal organic framework material, through topological functional design of a V-shaped organic ligand, a space confinement channel and a high-density oxygen active site are integrated in the same MOF material, and an ideal model system is provided for identification of water isotopes; according to the metal organic framework material, the framework structure flexibility, the pore channel confinement effect and the molecular recognition capability can be synergistically regulated and controlled, so that efficient recognition and separation of water / heavy water are realized.

The invention is applicable to the technical field of metal organic framework materials, and provides a pillararene-based metal organic framework material and a preparation method thereof.The pillararene-based metal organic framework material takes a compound PY2-P5 as a ligand, and the material is one of PMOF1, PMOF2 and PMOF3; the PMOF1 is of a Cu4I4 cubic tetramer structure; the PMOF2 is of a Cu4I4 ladder tetramer structure, and the Cu4I4 ladder tetramer structure is a And the PMOF3 has a CuI one-dimensional chain structure. By introducing the pillararene ligand and regulating and controlling the coordination mode of the pillararene ligand and cuprous iodide, the metal organic framework material with stable structure and functional characteristics is constructed, the metal organic framework material has the dual advantages of host recognition site and fluorescence signal response, and can selectively distinguish 1-bromoalkane and 2-bromoalkane; a remarkable fluorescent blue shift signal is shown in the adsorption process, so that the visualization of molecular recognition and sensing is realized; the excellent molecular recognition capability of pillararene is maintained, the stability and reusability of the material are improved through framing, and a new way is provided for selective detection and separation of volatile organic compounds.

The invention discloses a naphthoquinone-based gas sensitive material, a preparation method and application of the naphthoquinone-based gas sensitive material in an ammonia gas sensor, and belongs to the technical field of gas sensors. The material is composed of divalent metal ions such as copper, nickel and cobalt and a polysubstituted naphthoquinone organic ligand, forms a one-dimensional chain structure, has a high specific surface area, an ordered electron channel and excellent molecular recognition capability, and can detect toxic gases such as ammonia gas at room temperature with high sensitivity. Macroscopic preparation of the material can be realized through solvothermal one-step reaction. Compared with the prior art, the one-dimensional coordination structure and ligand site engineering synergistically improve the carrier transport and molecular recognition capability, can realize continuous, real-time and selective detection of ammonia gas under complex working conditions, and has the advantages of high yield, large-scale preparation and excellent device application prospect.

The application discloses a fluorine removal agent and a preparation method thereof, and relates to the technical field of fluorine removal agents, and comprises the following components in parts by weight: 5-10 parts of an aluminum salt, 5-10 parts of an iron salt, 15-20 parts of a rare earth material, sodium citrate and beta-cyclodextrin; the addition amount of the sodium citrate is 5%-10% of the total mass of the aluminum salt, the iron salt and the rare earth material; and the addition amount of the beta-cyclodextrin is 30%-50% of the mass of the sodium citrate. Through the introduction of the synergistic system of sodium citrate and beta-cyclodextrin, the metal ion precipitation sequence is regulated, meanwhile, the beta-cyclodextrin captures competitive anions through molecular recognition and constructs a hydrogen bond network to block interference, and the combination of the microsphere type and the porous particle type further realizes dynamic directional transmission of pollutants and nuclear pore limited crystallization, and the active site distribution is reconstructed at the molecular level, so that a technical scheme with universality, economy and reliability is provided for the treatment of complex fluorine-containing wastewater.

The invention relates to the technical field of separation membranes, in particular to a self-assembled ion separation membrane based on a pillararene derivative and a preparation method of the self-assembled ion separation membrane. The pillararene derivative and the triaminoguanidine hydrochloride are respectively dissolved, so that the problems of instant precipitation and phase separation easily caused by direct mixing are effectively avoided. Meanwhile, two functional monomers are ultrasonically dispersed, so that the problem of molecular agglomeration in the mixing process is avoided, the uniformity of reaction liquid is ensured, and a foundation is laid for subsequently forming a flawless separation membrane. The pillararene derivative contained in the separation membrane structure provides a macrocyclic pore structure with ion recognition capability, and triaminoguanidine hydrochloride acts on sites through multiple hydrogen bonds / ionic bonds, so that the selective separation performance of the membrane is further enhanced. Due to the collaborative design of the material, the material has precise molecular recognition capability and adjustable aperture, and can realize efficient selective separation of target objects such as small organic molecules, ions or dyes.

The present disclosure relates to methods and kits for analyzing a macromolecule. In some embodiments, the present disclosure relates to macromolecule analysis methods which employ barcoding and nucleic acid encoding of molecular recognition events. Also provided herein is a method and related kits for transferring information using a plurality of enzymes, including for performing a ligation, extension, and cleavage reaction with nucleic acid molecules associated with the macromolecule for analysis. In some embodiments, the macromolecule for analysis comprises a peptide, a polypeptide, or a protein.

The application belongs to the technical field of organic chemical synthesis, and particularly relates to a nitrogen center chiral base derivative, a preparation method and application thereof. The preparation method of the nitrogen center chiral base derivative provided by the application can effectively synthesize a base with only a nitrogen chiral center by using a tetrahydrodibenzo-diazocine compound as a raw material and through chiral phosphoric acid catalyzed amination reaction. Moreover, the synthesis method provided by the application has the advantages of high efficiency, simple steps and strong enantioselectivity, is suitable for industrialized production of chiral bases and derivatives thereof, and provides a new approach for research and application of chiral compounds. Meanwhile, the base derivative prepared by the application is a base molecule with a nitrogen center chirality, and has wide application prospects in the fields of molecular recognition, DNA binding, supramolecular chemistry, material science, asymmetric catalysis and drug development.

The invention belongs to the field of coordination polymers, and discloses an antiferromagnetic tetranuclear cobalt coordination polymer constructed by mixed polydentate ligands and a preparation method and application thereof. The chemical formula of the polymer is (C9H9O6) 2 (C26H18N4) 2 (OH) 2Co4. (H2O) 7, C9H9O6 is 1, 3, 5-cyclohexane tricarboxylic acid, C26H18N4 is 1, 2, 4, 5-tetrapyridyl benzene, the polymer is a monoclinic system and a P21 / c space group, the cell parameters are alpha = 90 degrees, beta = 96.166 (8) degrees and gamma = 90 degrees, and the polymer has few defects, high crystallinity and good stability and can be applied to the fields of adsorption separation, hydrogen storage, energy storage, molecular magnets, catalysis, sensing or molecular recognition and the like.

The invention discloses an application of fat-soluble ring-opened cucurbituril in specific recognition of organic compounds in organic solvents, the fat-soluble ring-opened cucurbituril is composed of glycoluril tetramer and terminal aromatic ring, the terminal aromatic ring is modified by phosphate side chain, and the terminal aromatic ring has good solubility in various organic solvents; according to the invention, the C-shaped adjustable cavity of the fat-soluble ring-opened cucurbituril is matched with the size of a guest molecule, and is matched with hydrogen bonds, pi-pi interaction and the like, so that efficient molecular recognition of organic matters in an organic solvent is realized; the application of the supramolecular macrocyclic main body in organic solvents is expanded by utilizing fat-soluble ring-opening cucurbituril, and the supramolecular macrocyclic main body is expected to be applied to the fields of medicine, chemical industry, environment and the like.

The invention discloses a sensing detection application and a sensor for identifying 6PPD and 6PPD-Q based on a cyclodextrin subject and object, and relates to the technical field of pollutant detection. Specifically, the invention provides an application of at least one of cyclodextrin, functional group modified cyclodextrin and polycyclodextrin in detection of 6PPD or 6PPD-Q. According to the invention, cyclodextrin, functional group modified cyclodextrin and polycyclodextrin can selectively recognize and combine with 6PPD and 6PPD-Q hydrophobic molecules through a subject-object inclusion effect. Cyclodextrin, functional group modified cyclodextrin and polycyclodextrin can be used as ideal molecular recognition elements of 6PPD and 6PPD-Q, have high selectivity and specificity, are convenient and fast to operate, can realize linear response to 6PPD in a concentration range of 0.01-30 [mu] M, and have a detection limit as low as 4.13 nM.

The present disclosure describes methods of detecting viral biomolecules such as viruses through frequency response. A method (200) of detecting a vims includes exposing (210) a sensor surface to a fluid sample containing a suspected virus. The sensor surface can be a surface of a resonator having a clean resonant frequency from about 1 MHz to about 1 GHz. The surface can be modified with molecular recognition groups selective for binding to the viral biomolecule. A resonant frequency of the resonator can be measured (220) after exposing the sensor surface to the fluid sample. The measured resonant frequency can be compared (230) with a clean resonant frequency indicating the presence of the viral biomolecule bound to the molecular recognition groups and then outputted (240) as a detection signal.

This invention discloses a method for synthesizing potassium 4-methoxysalicylate based on supramolecular-assisted methylation, belonging to the field of organic synthesis technology. The process is based on supramolecular chemistry principles and includes the following steps: (1) Preparation of a macrocyclic host molecule-methylating agent complex loaded with a methylating agent: The macrocyclic host molecule and the methylating agent are reacted at pH 7-9 and 25-40℃ to form a complex solution; (2) One-pot preparation of the target product: 2,4-dihydroxybenzoic acid is salted with potassium hydroxide, potassium carbonate is added, and the above complex solution is added dropwise. A selective methylation reaction is carried out at 55-65℃. After the reaction is complete, post-treatment yields the product. This invention utilizes the molecular recognition function of the macrocyclic host to achieve highly selective methylation of the 4-hydroxyl group under mild conditions. This process has the advantages of simple operation, high safety, low waste, and recyclable host molecules. The yield of potassium 4-methoxysalicylate can reach over 85%, and the purity exceeds 99.0%.

The invention relates to the technical field of biological medicines, in particular to a bupivacaine sustained-release injection as well as a preparation method and application thereof. The invention provides a bupivacaine drug compound. The bupivacaine drug compound contains an amide local anesthetic bupivacaine as an active component and a plurality of pharmaceutically acceptable slow-release carrier materials. The drug compound disclosed by the invention adopts a supramolecular synthesis strategy and is prepared into nano-particles through a self-assembly method of a molecular recognition mechanism between Ad and Cd. The novel bupivacaine nano-particles provided by the invention solve the problem of too fast release of the bupivacaine hydrochloride, the preparation method is simple, flexible and modularized, the nano-preparation with controllable carrier size, stable surface chemical property and high drug loading capacity is prepared, the slow release time in vivo can be prolonged, and the analgesic effect can be continuously exerted.

The invention discloses an immunochromatography detection kit for pesticide residues in food and a detection method, and relates to the technical field of food detection.The kit comprises an immunochromatography test strip and a sample extracting solution, the immunochromatography test strip is formed by sequentially overlapping and pasting a PVC bottom plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad, the lap joint width of the adjacent parts is 2-3mm; the synergistic effect of all parts of the immunochromatography test strip is optimized, a detection system with high targeting property is constructed, target pesticide residues are accurately captured and responded by virtue of specific recognition of a target triggering type hydrogel switch, the matrix influence is reduced by matching with a special sample extracting solution, and meanwhile, the molecular recognition and immunochromatography technologies are integrated, so that the detection efficiency is greatly improved. The target trigger type hydrogel switch has the advantages of high selectivity, stable signal marker activity, reasonable layout of a detection line and a quality control line, simplified pretreatment, simple operation, meeting of multi-scene batch detection, and provision of support for food quality safety supervision.

This application discloses a literature information extraction system for the field of chemistry, including a document parsing and preprocessing module, a general file cleaning module, an image processing module, an extraction and post-processing module, and a file integration and output module. The document parsing and preprocessing module is configured to parse and convert acquired PDF files in the field of chemistry, generating an initial general file, an image set, and literature citation information. The initial general file includes image links. The general file cleaning module is configured to perform text preprocessing on the initial general file, generating target general text. The image processing module is configured to sequentially perform molecular recognition processing on each image in the image set, generating image text description information. The extraction and post-processing module is configured to extract the target general text and image text description information, generating multiple types of extraction results. The file integration and output module is configured to integrate the multiple types of extraction results, inject literature citation information, and output the target file.

The invention belongs to the technical field of chemical separation, and discloses a separation method of a high-boiling-point component in high-carbon aldehyde production. The method is characterized in that 0.05%-2.0% of functional ionic liquid is added into a rectification system, and the apparent vapor pressure of impurities is directionally inhibited and the relative volatility is remarkably improved by utilizing the selective hydrogen-bond interaction between anions of the functional ionic liquid and hydroxyl / carbonyl in the impurities. According to the method, the ionic liquid with a molecular recognition function is introduced, the phase equilibrium relation between the high-carbon aldehyde and the high-boiling-point impurities is reconstructed from the thermodynamic essence level, the inherent limitation that traditional rectification depends on weak physical property differences is broken through, efficient, low-energy-consumption and high-stability purification of the high-carbon aldehyde product is achieved, the ionic liquid can be recycled, and the method is suitable for industrial production. The invention provides a novel high-carbon aldehyde purification method which has the advantages of novel principle, simplicity and convenience in operation, high efficiency, energy conservation and industrial feasibility.

The invention discloses a preparation method of a two-dimensional chiral MXene membrane based on carboxymethyl-beta-cyclodextrin modification and application of the two-dimensional chiral MXene membrane in the aspect of enantiomer separation. The core of the invention lies in that the cyclodextrin is stably and orderly fixed in a two-dimensional mass transfer channel through a covalent reaction between carboxymethyl of the cyclodextrin and a functional group on the surface of MXene by utilizing the molecular recognition capability of a cyclodextrin cavity; furthermore, the highly organized cyclodextrin units are used as accurate'chiral probes' and cooperate with the high permeability of an MXene channel, so that efficient screening of enantiomers is realized, and meanwhile, excellent separation selectivity and flux are guaranteed.

The application belongs to the technical field of molecular detection, and discloses a medicinal material identification system and method; the method comprises the following steps: emitting a topological protection acoustic wave to concentrate DNA of medicinal materials, marking the DNA with a CdTe quantum dot-nucleic acid probe, scraping the sample to extract DNA and performing PCR amplification, designing a logic gate staple chain to prepare a light-controlled origami probe, and injecting a PZT chip nano-pore array to be light-activated, and then, through AFM analysis of free energy, the medicinal materials are identified; the application constructs a complete technical chain from molecular recognition to reliable storage, and comprehensively solves multiple technical bottlenecks of traditional methods in medicinal material identification.

The invention relates to the technical field of alcohol detection, in particular to a preparation method of a metal-based energy-consumption-free alcohol detection material and an application method of the metal-based energy-consumption-free alcohol detection material in alcohol concentration detection and alcohol molecule recognition. A continuous groove micro-nano structure is machined on the surface of a substrate material, chemical composition is changed, and the continuous groove micro-nano structure comprises a plurality of grooves with preset widths, perpendicular to the length direction, in a laser processing area with the preset length; the depth of the groove is 8-12 microns, and the width of the groove is 30-40 microns; the alcohol concentration can be identified according to the diffusion length of alcohol on the surface, and meanwhile whether gas contains alcohol or not can be detected by changing the surface contact angle and the rolling angle. The substrate material is convenient and rapid to prepare and low in cost, and the method for detecting the alcohol concentration and identifying the alcohol molecules is simple to operate, saves a detection solvent and is short in time consumption.

A method is provided to simultaneously identify and quantify critical structure attributes (CSAs) in proteoforms or proteoform families that includes the steps of:1. injecting a sample into a reagent stream of one or more detection enhanced molecular recognition reagents;2. incubating the combined sample:reagent(s) during migration through an analytical platform the causes molecular recognition reagent(s) to be sequestered by a specific critical structure attribute (CSA) in the analyte to form a luminon (An:*Sas) complex;3. using a sequestron selector in the reagent stream to overtake the luminon complex in a down-stream size exclusion chromatography (SEC) column to achieve mixing and formation of an Nc˜Pas:An:*Sas, Pas:An:*Sas, or *Pas:An:*Sas sequestome complex;4. resolving this sequestome complex from any unbound affinity selector(s) such as *Sas or *Pas, and non-analytes in the SEC column;5. transporting the resolved sequestome complex into a flow-through detection means that detects and quantifies CSAs in fluorescent labeled *Sas or *Pas bearing luminon or sequestome complex to generate data for the construction of critical structure attribute ratio plots as a function of elapsed fermentation time.

This invention provides a sensor and its preparation method for detecting aflatoxin B1, belonging to the fields of analytical chemistry and food safety detection technology. The sensor includes a fluorescence quenching unit and a molecular recognition and signaling unit. The fluorescence quenching unit is an amino-functionalized zirconium-based metal-organic framework material UiO-66-NH2. The molecular recognition and signaling unit is a specific nucleic acid aptamer for aflatoxin B1, one end of which is covalently modified with a fluorescent dye. The nucleic acid aptamer binds to the surface of UiO-66-NH2 through adsorption. In the absence of aflatoxin B1, the fluorescence is quenched; in the presence of aflatoxin B1, the nucleic acid aptamer binds to the target analyte and dissociates from the UiO-66-NH2 surface, restoring fluorescence. This invention constructs a fluorescence "turn-on" sensor based on the UiO-66-NH2 / TAMRA aptamer, possessing both high sensitivity and specificity. Through visualization hydrogel technology, it achieves low-cost, rapid, and on-site detection of aflatoxin B1 in complex matrices.

The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.

The invention relates to the technical field of inorganic salt purification, and discloses high-purity ammonium sulfate and a preparation process thereof.The preparation process includes the following steps that firstly, a magnetic response macrocyclic ether complexing agent is added into an ammonium sulfate solution to be purified, the complexing agent can specifically capture impurities such as potassium ions, and a stable complex with magnetic responsiveness is formed; then, selectively crystallizing and separating out the target product ammonium sulfate under a mild condition by a gas-phase anti-solvent crystallization method, and meanwhile, effectively repelling a large-volume impurity complex into a mother solution. The key step is that obtained solid-liquid mixed crystal mush is introduced into a gradient magnetic field for enhanced separation. Through creative integration of molecular recognition, phase equilibrium engineering and a magnetochemical separation technology, the limitation of a co-crystallization effect is fundamentally broken through, and ultra-high-purity ammonium sulfate with extremely low impurity content can be prepared in an efficient and environment-friendly manner.

This invention belongs to the field of water treatment agent technology, and discloses a sepiolite composite material, its preparation method, and its application in leather tanning wastewater. The sepiolite composite material includes: a sepiolite carrier; a quaternary ammonium salt molecular layer gradient-anchored on the surface of the sepiolite carrier, wherein the quaternary ammonium salt molecular layer includes dodecyltrimethylammonium chloride and hexadecyltrimethylammonium chloride; and β-cyclodextrin molecules bound to the surface of the quaternary ammonium salt molecular layer through intermolecular forces. This invention successfully constructs a dual-functional interface on the sepiolite surface, possessing both a "broad-spectrum hydrophobic adsorption domain" (quaternary ammonium salt layer) and a "specific molecular recognition domain" (cyclodextrin layer). This design overcomes the limitations of single modified materials, achieving a synergistic effect of graded capture and synergistic locking of oily contaminants, significantly improving the overall adsorption performance and selectivity of the composite material in complex systems.

According to one embodiment of the present invention, a method for assaying a biomolecule may be provided. The method comprises: providing a recognition unit comprising a conductive polymer and a molecular recognition pH indicator that functions as a dopant for the conductive polymer and recognizes a target biomolecule; a sample containing the target biomolecules is introduced into the recognition unit; measuring an electrical characteristic of the conductive polymer on the basis of a reaction of the target biomolecule with the molecular recognition pH indicator occurring when the target biomolecule is introduced; and determining the amount of the target biomolecule in the sample on the basis of the measured electrical characteristics.

This invention provides a macrocyclic crosslinked anion exchange membrane constructed using host-guest recognition, its preparation method, and its application. First, a large-volume rigid crosslinking agent, CDIC, is synthesized by using a saturated aqueous solution method to include nonpolar molecules via the host-guest molecular recognition of β-cyclodextrin. Second, a membrane-forming material is prepared by first chloromethylating the polymer and then functionalizing it. Finally, CDIC is introduced into the membrane-forming material to promote the formation of microphase separation structures within the membrane, resulting in a macrocyclic crosslinked anion exchange membrane. The anion exchange membrane synthesized by this invention can be applied in the field of electrodialysis water treatment. The preparation process is simple, the raw materials are inexpensive and readily available, and the resulting anion exchange membrane exhibits suitable water absorption and optimal microphase separation structures at a relatively low charged group density, thereby effectively improving the selectivity and ion transport flux of the anion exchange membrane and providing a new preparation strategy for electrodialysis water treatment devices.

The invention discloses an iron-based nano-enzyme targeting chimera as well as a preparation method and application thereof. According to the chimera, lipidosome is used as a carrier, a coordination active center is constructed by Plerixabor with CXCR4 high affinity and iron ions, selective adsorption of transferrin is achieved through surface chemical design, and double-target tumor targeted enrichment is achieved by means of TfR1-mediated rapid endocytosis. And meanwhile, selective degradation of CXCR4 through a lysosome way is accelerated, so that synergistic treatment of'blocking transfer signals-chemical kinetics killing 'is realized. The preparation provided by the invention has good biocompatibility and expandability. The platform has the advantages of molecular recognition, protein crown regulation and control, microenvironment response and the like, is suitable for precise treatment of various tumors with high CXCR4 expression, and can be used as a universal membrane protein degradation and chemical kinetics treatment integrated carrier to be expanded and applied.

The invention belongs to the technical field of biological medicine, and particularly relates to an aromatic heterocyclic compound, a preparation method thereof and application of the aromatic heterocyclic compound in tumor resistance. According to the aromatic heterocyclic compound disclosed by the invention, the structural design is based on a structure-activity optimization concept of a bisaryl structure, and the core pyrrolo aromatic ring structure can realize pi-pi stacking and hydrogen bond coordination on a molecular level, so that stable molecular recognition is favorably formed with a protein kinase active pocket or a microtubule binding region; a nitrogen atom of the heterocyclic ring part is used as a hydrogen bond acceptor and forms stable hydrogen bond interaction with a target protein hinge region or key amino acid residues, so that the binding capacity of the compound and a kinase target is enhanced; substituent groups on the aromatic ring part can influence coplanarity and hydrophobic interaction of molecules by adjusting electron cloud density, so that compatibility with a target protein hydrophobic pocket is enhanced; the polarity distribution of the substituent group gives consideration to the solubility and membrane permeability of the compound at the same time, so that the accessibility and pharmacokinetic stability of a pharmacophore at a cellular level are ensured.

The application discloses a kind of phenthiazine-based two-dimensional covalent organic framework materials constructed by supramolecular inclusion complex and application thereof, belong to the field of biological medicine.The phenthiazine-based two-dimensional covalent organic framework material takes 4,4',4'',4'''-(anthracene-9,10-diylbis(10H-phenthiazine-10,3,7-triyl)) tetrakisbenzaldehyde and beta-CD dithylamine inclusion complex as structural unit, and is obtained by solvothermal reaction two-dimensional crystalline porous copolymer.The application utilizes supramolecular inclusion complex and copolymerization of phenthiazine derivative and beta-CD dithylamine to obtain PTz-CD-COF with negligible biological toxicity, the material can also realize the synergistic effect of photodynamic therapy and photothermal therapy simultaneously, and cyclodextrin forms "PDT-PTT-cyclodextrin mediated synergistic" multi-component synergistic treatment system through its unique molecular recognition and inclusion effect.