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199 results about "Enhanced sensitivity" patented technology
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The Enhanced Sensitivity Flex Set can detect as low as 0.274 pg/mLmore than a 35-fold improvement. This allows researchers to get quantitative results in samples that were previously below the level of detection.
Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
InactiveUS6203987B1Peptide/protein ingredientsMicrobiological testing/measurementCo-regulationIndividual gene
The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes are then used as the basis for comparison and detection of biological responses with greatly enhanced sensitivity.
Owner:MICROSOFT TECH LICENSING LLC
Novel folded Mach-Zehnder interferometers and optical sensor arrays
The invention provides novel “folded” Mach-Zehnder interferometers (“folded” MZI's), methods for making folded MZI's, and systems and devices incorporating them. The novel folded MZI's are elaborated from conventional MZI structures by cutting across the interferometer arms of a conventional MZI structure and creating reflectors on the exposed ends of the interferometer arms to form two “folded” MZI's from a single conventional Mach-Zehnder interferometer structure. The novel folded MZI's show promise as sensors having a reduced size and enhanced sensitivity relative to sensors incorporating conventional Mach-Zehnder Interferometers.
Owner:GENERAL ELECTRIC CO
Visible/near infrared image sensor
InactiveUS20050104089A1Improve performanceHigh sensitivityTelevision system detailsTelevision system scanning detailsLow earth orbitBeam steering
A MOS or CMOS sensor for high performance imaging in broad spectral ranges including portions of the infrared spectral band. These broad spectral ranges may also include portions or all of the visible spectrum, therefore the sensor has both daylight and night vision capabilities. The sensor includes a continuous multi-layer photodiode structure on a many pixel MOS or CMOS readout array where the photodiode structure is chosen to include responses in the near infrared spectral ranges. A preferred embodiment incorporates a microcrystalline copper indium diselenide / cadmium sulfide photodiode structure on a CMOS readout array. An alternate preferred embodiment incorporates a microcrystalline silicon germanium photodiode structure on a CMOS readout array. Each of these embodiments provides night vision with image performance that greatly surpasses the GEN III night vision technology in terms of enhanced sensitivity, pixel size and pixel count. Further advantages of the invention include low electrical bias voltages, low power consumption, compact packaging, and radiation hardness. In special preferred embodiments CMOS stitching technology is used to provide multi-million pixel focal plane array sensors. One embodiments of the invention made without stitching is a two-million pixel sensor. Other preferred embodiments available using stitching techniques include sensors with 250 million (or more) pixels fabricated on a single wafer. A particular application of these very high pixel count sensors is as a focal plane array for a rapid beam steering telescope in a low earth orbit satellite useful for tracking over a 1500-meter wide track with a resolution of 0.3 meter.
Owner:C PHOCUS
Bioanalysis systems including optical integrated circuit
InactiveUS6956651B2Reduce decreaseImprove throughputScattering properties measurementsColor/spectral properties measurementsMicrowell PlateReduced size
Optical Integrated Circuits (OIC) in Surface Plasmon Resonance (SPR) Analysis Systems combined with micorarray or microwell plates to provide enhanced sensitivity, stability, speed of analysis and reduced size are disclosed. Using the OIC with other optical analysis methods to provide enhance analysis systems is also disclosed.
Owner:LIGHTWAVE BIOAPPL
Digital beamforming for an electronically scanned radar system
ActiveUS20070001897A1Improve performanceLow costParticular array feeding systemsRadio transmissionRadar systemsGrating lobe
Digital beamforming is provided for use with electronically scanned radar. In an aspect, the present invention provides enhanced sensitivity, wide angle or field of view (FOV) coverage with narrow beams, minimized number of receivers, reduced sidelobes, eliminated grating lobes and beam compensation for target motion. In an aspect, the present invention employs a uniform overlapped subarray feed network, a time multiplexed switch matrix, and a restructured digital signal processor. Antenna channels share a receiver, rather than maintain a dedicated receiver for each antenna element, as in conventional systems. In an aspect, Doppler / frequency filtering is performed on each antenna element or subarray output prior to digital beamforming. Further, Doppler compensation is employed following Doppler / frequency filtering, followed by digital beamforming.
Owner:APTIV TECH LTD
Resonant optical cavities for high-sensitivity high-throughput biological sensors and methods
InactiveUS7384797B1Promote generationIncrease exposureBioreactor/fermenter combinationsBiological substance pretreatmentsWhispering galleryEnhanced sensitivity
Biosensors including resonant optical cavities. The resonant optical cavities are shaped so as to generate whispering gallery modes, which increase the quality factors of the cavities and facilitate the detection of analytes in a sample with enhanced sensitivity. The sizes of the resonant optical cavities facilitate their use in biosensors that include arrays of sensing zones. Accordingly, the resonant optical cavities may be used in high-density sensing arrays that can be read in real-time and in parallel. Thus, the resonant optical cavities are useful for detecting small concentrations of samples in real-time and with high throughput. Different embodiments of the biosensors are also disclosed, as are methods for using the biosensors.
Owner:UNIV OF UTAH RES FOUND
Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
ActiveUS20080181827A1SamplingChemiluminescene/bioluminescenceRelative motionSignal-to-quantization-noise ratio
A method and system for using spatially modulated excitation / emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation / emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
Owner:XEROX CORP
NMR probe
ActiveUS6914430B2Inhibit heat shrinkageHigh sensitivityElectric/magnetic detectionMeasurements using magnetic resonanceNMR - Nuclear magnetic resonanceMagnet
Owner:JEOL LTD
Digital beamforming for an electronically scanned radar system
ActiveUS7474262B2Improve performanceLow costParticular array feeding systemsRadio transmissionRadar systemsEngineering
Digital beamforming is provided for use with electronically scanned radar. In an aspect, the present invention provides enhanced sensitivity, wide angle or field of view (FOV) coverage with narrow beams, minimized number of receivers, reduced sidelobes, eliminated grating lobes and beam compensation for target motion. In an aspect, the present invention employs a uniform overlapped subarray feed network, a time multiplexed switch matrix, and a restructured digital signal processor. Antenna channels share a receiver, rather than maintain a dedicated receiver for each antenna element, as in conventional systems. In an aspect, Doppler / frequency filtering is performed on each antenna element or subarray output prior to digital beamforming. Further, Doppler compensation is employed following Doppler / frequency filtering, followed by digital beamforming.
Owner:APTIV TECH LTD
Waveguide immunosensor with coating chemistry and providing enhanced sensitivity
InactiveUS7022515B2High strengthOptical radiation measurementBioreactor/fermenter combinationsCouplingWaveguide
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
Owner:UNIV OF UTAH RES FOUND
Particulate labels
InactiveUS20120045748A1High sensitivitySolve the poor convenience of useMicrobiological testing/measurementParticulatesMolecular diagnostics
A methodology for bioassays and diagnostics in which a particulate label (ranging in size from nm-scale molecular assemblages to organisms on the scale of tens or hundreds of microns), such as, but not limited to, nanoparticles, bacteria, bacteriophage, Daphnia, and magnetic particles, serve carriers for analytes bound by molecular recognition elements such as antibodies, aptamers, etc. The described methodology is generally applicable to most pathogen assays and molecular diagnostics and also leads to enhanced sensitivity and convenience of use.
Owner:WILLSON RICHARD C +2
Applications of laser-processed substrate for molecular diagnostics
Owner:EBSTEIN STEVEN M
Quadrupole mass spectrometer with enhanced sensitivity and mass resolving power
ActiveUS8389929B2Low costImprove robustnessStability-of-path spectrometersSpectrometer detectorsMass analyzerQuadrupole
Owner:THERMO FINNIGAN
Evanescent microwave probe with enhanced resolution and sensitivity
InactiveUS20060125465A1High sensitivityImprove resolutionResistance/reactance/impedenceElectrical testingActive feedbackImage resolution
Novel systems of an evanescent microwave probe (EWP) are disclosed, which enable measurements of physical properties of a sample with enhanced sensitivity and resolution, simultaneously. In one embodiment, new shielding features are added to the probe (which may be of either a sharpened tip or loop configuration) to reduce the effects of residual far field radiation, while maintaining the probe section that extends beyond the shielding aperture of the resonator. To further increase the sensitivity of the instrument, an automatic gain-controlled active feedback loop system may be added to the probe resonator to form a self-oscillator. This new active circuit feature significantly increases the effective Q of the resonator probe, enhancing the sensitivity of both the frequency and Q measurement.
Owner:INTEMATIX
S-band low-noise amplifier with self-adjusting bias for improved power consumption and dynamic range in a mobile environment
InactiveUSRE41582E1Improve dynamic rangeReduce noiseResonant long antennasGain controlAudio power amplifierPower detector
A discrete low-noise amplifier designed to operate in a mobile wireless environment uses two cascaded GaAs FETs to achieve 25 dB gain and 0.9 dB noise figure at 2.5 GHz. Active bias control circuitry responsive to monitored amplifier output power automatically and continuously adjusts the drain-source currents, and the load lines, of the cascaded FETs to (i) maintain power consumption at 33 milliwatts in nominal small-signal conditions, and to (ii) provide an elevated input third-order intermodulation intercept point (IP3) and a reduced noise figure during the presence of jamming. A 15 dB improvement in the input IP3 is achieved in large-signal operation. Amplifier operation is supported by an a.c. power detector of enhanced sensitivity and responsiveness because of un-grounded operation.
Owner:RGT UNIV OF CALIFORNIA
Bioanalysis systems including optical integrated circuit
InactiveUS20060205092A1Reduce decreaseFaster and simpler discoveryScattering properties measurementsColor/spectral properties measurementsMicrowell PlateReduced size
Optical Integrated Circuits (OIC) in Surface Plasmon Resonance (SPR) Analysis Systems combined with micorarray or microwell plates to provide enhanced sensitivity, stability, speed of analysis and reduced size are disclosed. Using the OIC with other optical analysis methods to provide enhance analysis systems is also disclosed.
Owner:LACKRITZ HILARY S +3
Quadrupole Mass Spectrometer With Enhanced Sensitivity And Mass Resolving Power
ActiveUS20110215235A1Low costImprove robustnessStability-of-path spectrometersSpectrometer detectorsMass analyzerQuadrupole
A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential.
Owner:THERMO FINNIGAN
Laser scanner module having integral interface with hand-held data capture terminal, proximity and label sensing, and enhanced sensitivity and power efficiency
InactiveUS20070007353A1Big economyWide rangeSensing by electromagnetic radiationLaser scanningHand held
Owner:DANIELSON ARVIN D +2
Applications of laser-processed substrate for molecular diagnostics
ActiveUS20070115469A1Facilitate SERS analysisMaterial nanotechnologyRadiation pyrometryChemical reactionPhotonics
Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.
Owner:EBSTEIN STEVEN M
Air-Coupled Acoustic Thermography for In-Situ Evaluation
InactiveUS20100019153A1High-degree of flaw/damage sensitivityGood repeatabilityVibration measurement in solidsRadiation pyrometrySound sourcesAir coupled
Acoustic thermography uses a housing configured for thermal, acoustic and infrared radiation shielding. For in-situ applications, the housing has an open side adapted to be sealingly coupled to a surface region of a structure such that an enclosed chamber filled with air is defined. One or more acoustic sources are positioned to direct acoustic waves through the air in the enclosed chamber and towards the surface region. To activate and control each acoustic source, a pulsed signal is applied thereto. An infrared imager focused on the surface region detects a thermal image of the surface region. A data capture device records the thermal image in synchronicity with each pulse of the pulsed signal such that a time series of thermal images is generated. For enhanced sensitivity and / or repeatability, sound and / or vibrations at the surface region can be used in feedback control of the pulsed signal applied to the acoustic sources.
Owner:NASA
Biosensors having enhanced environmental sensitivity
InactiveUS7010182B2High sensitivityHigh binding capacityCladded optical fibreMaterial analysis by observing effect on chemical indicatorDendrimerPhysical chemistry
A biosensor having enhanced sensitivity to physical or chemical parameters comprises a waveguide and a coating disposed on the waveguide. The coating has a refractive index that enhances the sensitivity of the biosensor to physical or chemical parameters. In a preferred embodiment, the coating comprises at least one dendrimer disposed on the waveguide, wherein the coating has a refractive index ranging from about 1.0 to about 1.5. A method for fabrication of the biosensor is also provided.
Owner:LUNA INNOVATIONS
Optical Sensor with Enhanced Sensitivity
ActiveUS20130323858A1Improve signal-to-noise ratioComponent separationRaman scatteringAnalyteNanohole
The invention is a surface plasmon resonance (SPR) sensor to determine the presence and quantity of biological or chemical entities in an analyte. The sensor comprises a metal periodic structure deposited as a thin layer of a noble metal, comprising a one dimensional array of nanoslits or a two dimensional array of nanoholes on a transparent dielectric substrate, a nm-thick layer of transparent dielectric protection layer on top of the metal periodic structure and a functionalization layer, which acts as a binding layer to biological or biochemical entities in an analyte that is in contact with the functionaliztion layer.
Owner:BEN GURION UNIVERSITY OF THE NEGEV
Laser-processed substrate for molecular diagnostics
ActiveUS20090279085A1Facilitate SERS analysisMaterial nanotechnologyRadiation pyrometryChemical reactionPhotonics
Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.
Owner:EBSTEIN STEVEN M
Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
InactiveUS20090204333A1Less vulnerableReduced dimensionBioreactor/fermenter combinationsBiological substance pretreatmentsBiologic responseMethod comparison
The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile.The methods of the invention have many useful applications, particularly in the fields of drug development and discovery. For example, the methods of the invention may be used to compare biological responses with greatly enhanced sensitivity. The biological responses that may be compared according to these methods include responses to single perturbations, such as a biological response to a mutation or temperature change, as well as graded perturbations such as titration with a particular drug. The methods are also useful to identify cellular constituents, particularly genes, associated with a particular type of biological response. Further, the methods may also be used to identify perturbations, such as novel drugs or mutations, which effect one or more particular genesets. The methods may still further be used to remove experimental artifacts in biological response data.
Owner:MICROSOFT TECH LICENSING LLC
Detector for a bipolar time-of-flight mass spectrometer
InactiveUS6958474B2High sensitivityEliminate potential damageTelevision system detailsParticle separator tubesElectron multiplierSpectrometer
A replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity is disclosed. A mass detector is electro-optically isolated from a charge collector with an electron multiplier for converting a charged particle into a multiplicity of electrons and a scintillator for converting the multiplicity of electrons into a multiplicity of photons. A light sensor is provided to convert the multiplicity of photons back into electrons which are summed into a charge pulse. The light sensor is realized by any of a plurality of photo-responsive devices.
Owner:PHOTONIS SCI INC
Microcantilever with Reduced Second Harmonic While in Contact with a Surface and Nano Scale Infrared Spectrometer
ActiveUS20110061452A1Operation and useNanotechnologyMechanical roughness/irregularity measurementsHarmonicAbsorbance
Described herein are devices and methods for sensing pulsed forces. Some of the described devices and methods are also useful for measuring infrared absorbances and compiling spectral and chemical maps of surfaces. Also described are microcantilever having reduced harmonic frequencies when operating in contact mode. Some of the described microcantilevers comprise an internal resonator configured to vibrate substantially independent of friction between the microcantilever tip and a surface when the microcantilever operates in contact mode. A number of the described devices and methods are useful for monitoring pulsed forces with enhanced sensitivity.
Owner:BRUKER NANO INC +1
Integrated microchip sensor system for detection of infectious agents
InactiveUS20110136262A1Rapid direct early detectionHigh sensitivityMaterial analysis using sonic/ultrasonic/infrasonic wavesComponent separationSingle crystalMicrofluidic channel
An integrated multiplexed acoustic wave biosensor chip system with enhanced sensitivity has been developed. The biosensor system incorporates one or more microfluidic channels, coated with target-specific binding films enabling rapid and early detection of viral, bacterial or parasitic targets such as Dengue virus and sexually transmitted diseases in specimens from potentially infected patients. The biosensors are used in portable analytical systems that are suitable for real-time point of care (POC) clinical diagnosis in cost sensitive and / or resource limited settings. The highly sensitive biosensors utilize thinned single crystal piezoelectric substrates that propagate layer guided shear horizontal acoustic plate mode (LG-SH-APM) waves in sensing regions bearing immobilized binders that provide simultaneous and direct detection of mass changes due to multiple bound target pathogens or molecules.
Owner:AVIANA MOLECULAR TECH
Coated surfaces with high capacity for capturing target molecules
InactiveUS6638728B1Large capacityHigh sensitivityBioreactor/fermenter combinationsAnalysis using chemical indicatorsBiotin-streptavidin complexCoated surface
New protein coated surfaces, which have a high capacity for capturing target molecules, thus yielding assays with enhanced sensitivity, are disclosed. Surfaces prepared according to the present invention contain a coating consisting essentially of streptavidin, avidin or "NeutrAvidin" in polymeric form, wherein polymerization has been controlled to an extent such that the polymer is predominantly dimers, trimers and tetramers of the native molecule.
GMR biosensor with enhanced sensitivity
ActiveUS20080032423A1Adverse hysteresis effectPointing stableNanomagnetismBiological particle analysisHysteresisSensor array
A sensor array comprising a series connection of parallel GMR sensor stripes provides a sensitive mechanism for detecting the presence of magnetized particles bonded to biological molecules that are affixed to a substrate. The adverse effect of hysteresis on the maintenance of a stable bias point for the magnetic moment of the sensor free layer is eliminated by a combination of biasing the sensor along its longitudinal direction rather than the usual transverse direction and by using the overcoat stress and magnetostriction of magnetic layers to create a compensatory transverse magnetic anisotropy. By making the spaces between the stripes narrower than the dimension of the magnetized particle and by making the width of the stripes equal to the dimension of the particle, the sensitivity of the sensor array is enhanced.
Owner:APPLIED SPINTRONICS +1
Electron multiplier with enhanced ion conversion
InactiveUS7026177B2High sensitivityEliminate potential damageThermometer detailsSpectrometer detectorsRubidiumElectron multiplier
A replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity is disclosed. A coating on the MCP that enhances the secondary electron emissivity characteristics of the MCP is selected from aluminum oxide (Al2O3), magnesium oxide (MgO), tin oxide (SnO2), quartz (SiO2), barium flouride (BaF2), rubidium tin (Rb3Sn), berrylium oxide (BeO), diamond and combinations thereof. A mass detector is electro-optically isolated the from a charge collector with a method of detecting a particle including accelerating the particle with a voltage, converting the particle into a multiplicity of electrons and converting the multiplicity of electrons into a multiplicity of photons. The photons then are converted back into electrons which are summed into a charge pulse. A detector also is provided.
Owner:PHOTONIS SCI INC
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