122 results about "Diselenide" patented technology

The invention discloses an active oxygen scavenging drug-loaded targeted nano delivery platform based on diselenide bond bridging as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the invention, tetra (4-carboxyphenyl) porphyrin (TCPP) and manganese porphyrin (Mn-TCPP) are used as raw materials to synthesize an organic metal framework MOFs, a target drug is loaded on the MOFs through electrostatic adsorption / blending, and amino and diselenide bonds are linked on the MOFs to realize combination with a specific peptide ligand and promote release of a drug oxidative stress microenvironment. The nano delivery platform with specific targeting and ROS response performance is obtained. The specific treatment effect of different diseases is achieved through different selections of the loaded drugs and the specific peptide ligands.

The invention belongs to the technical field of nano composite materials, and relates to a preparation method of an iron diselenide / nitrogen-sulfur co-doped carbon nanosheet composite material, which comprises the following steps: putting cellulose, sodium bicarbonate and thiourea into a mortar, uniformly grinding, putting into a tubular furnace, calcining at high temperature under the protection of inert gas, naturally cooling, centrifugally separating and collecting the calcined powder, thereby obtaining the iron diselenide / nitrogen-sulfur co-doped carbon nanosheet composite material. The nitrogen and sulfur co-doped carbon nanosheets are obtained; ultrasonically dispersing iron nitrate nonahydrate in ethanol, heating in an oil bath until the ethanol is evaporated to dryness, and carrying out heat treatment to obtain an iron-based precursor; the obtained iron-based precursor, selenium dioxide and nitrogen and sulfur co-doped carbon nanosheets are ultrasonically dispersed in benzyl alcohol, the mixture is transferred into a reaction kettle with a polytetrafluoroethylene lining, the composite material is obtained after solvothermal reaction, and the morphology of the composite material is that iron diselenide nanoparticles are evenly and densely attached to the surfaces of the nitrogen and sulfur co-doped carbon nanosheets. The method is simple and easy to implement, suitable for large-scale production, easy to implement industrially and expected to be applied to the negative electrode of the hybrid supercapacitor.

The invention provides a preparation method of an alpha-difluoroselenomethyl ketone derivative, which is a method for preparing the alpha-difluoroselenomethyl ketone derivative by using 2, 2-difluoroolefin and dialkyl diselenide in the presence of iodosobenzene diacetate. The preparation method specifically comprises the following steps: dissolving 2, 2-difluoroolefin and a dialkyl diselenide compound in an organic solvent, uniformly mixing, adding iodobenzene diacetate, and stirring and reacting at a certain temperature in an air atmosphere to obtain the product alpha-difluoro (seleno) methyl ketone derivative. The alpha-difluoroselenomethyl ketone derivative can be mildly and efficiently obtained by only adopting iodobenzene diacetate without necessary catalysts, alkali, persulfide and persulfate compounds in the prior art. Wherein R1 and R2 are aliphatic hydrocarbon, substituted and unsubstituted benzene, substituted and unsubstituted naphthalene or other aromatic groups.

The present invention discloses a preparation method of dendritic two-dimensional PdSe2, belonging to the field of preparation of nonlinear materials. Using KCl as a transport agent, PdCl2 and Se are added into a quartz tube with a specific structure according to the atomic ratio of Pd / Se of 1:1, and the quartz tube is evacuated to 10 ‑3 Pa and then flame-sealed to form a high-vacuum environment inside the quartz tube. The dendritic two-dimensional PdSe2 is obtained through heating reaction. The preparation process of the present invention is simple, the product is dendritic, with a small thickness and large size, and the surface of the product is rich in a large number of defects, which is of great significance for promoting the development of optoelectronics.

The present invention discloses a method for synthesizing 1,1-diselenoolefin compounds. An alkenylthianthrenium salt compound (1a), a diselenide compound (1b) and a base are mixed, and under nitrogen protection, a solvent is added. After reacting at room temperature for 5 to 6 hours, the product 1,1-diselenoolefin compound (1c) is obtained through post-treatment; this method has simple operation, mild conditions, no metal catalysis, and the final products can all have a medium or higher yield;

The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a preparation method and medical application of a visible-light-driven bis (trifluoromethyl) selenide compound. The preparation method of the bis (trifluoromethyl) selenide compound comprises the following steps: by taking olefin, trifluoromethylselenotetramethylammonium and bis (trifluoromethylseleno) diselenide as reaction raw materials, stirring and reacting under the conditions of proper temperature and visible light irradiation in the presence of cuprous salt to obtain the bis (trifluoromethyl) selenide compound. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, good functional group compatibility and the like. In addition, the bis (trifluoromethyl) selenide compound provided by the invention shows good potential in the aspect of anticonvulsion, and has the prospect of being further developed into anticonvulsion drugs.

The application belongs to the technical field of two-dimensional thin film material growth and preparation, and discloses a kind of platinum diselenide and its preparation method and application, the morphology of the platinum diselenide is square single crystal, nanostructure with dendritic characteristics, sheet or continuous film.The application is innovative in morphology and product form, not only prepares platinum diselenide with square single crystal morphology, but also creates favorable conditions for fully exerting its potential different optoelectronic device applications, and can realize controllable preparation of square single crystal, nanostructure with dendritic characteristics, sheet and continuous film morphology through simple parameter adjustment.In terms of process compatibility, with low-temperature preparation process, the temperature limitation of traditional high-temperature method is effectively avoided, and the limitation of crystal domain size in traditional low-temperature method is broken through, and crystal lateral size meeting the actual application requirements can be obtained, providing a key guarantee for adaptation with existing processes.

The invention discloses a preparation method of a three-layer heterojunction for a sodium ion battery negative electrode material. The three-layer structure of the heterojunction is nickel diselenide / nitrogen-doped biomass charcoal / cobalt diselenide in sequence. The preparation method comprises the following steps: by taking biomass charcoal, urea, selenium powder, a nickel source and a cobalt source as raw materials, pre-carbonizing the biomass charcoal at high temperature, calcining the pre-carbonized biomass charcoal and urea at high temperature in inert gas to obtain nitrogen-doped biomass charcoal, growing cobalt diselenide / nitrogen-doped biomass charcoal by a solvothermal method, and preparing the cobalt diselenide / nitrogen-doped biomass charcoal. And finally, the nickel diselenide / nitrogen-doped biomass charcoal / cobalt diselenide three-layer heterojunction is prepared through interface assembly. The preparation method is characterized in that a solvothermal method, a high-temperature calcination method and an interface assembly method are simultaneously applied to the preparation process of the material, and when the material is used as a sodium-ion battery composite negative electrode material, the material has relatively high cycling stability and conductivity and shows excellent electrochemical performance. The method is safe in process and stable in yield.

The invention discloses a room-temperature DMMP sensor based on a platinum diselenide van der Waals heterojunction, and relates to the technical field of gas sensing. The sensor comprises an electrode, a platinum diselenide layer loaded on the surface of the electrode and a nano material loaded on the surface of the platinum diselenide layer, wherein the platinum diselenide layer and the nano material form a Van der Waals heterojunction; wherein the nano material is a low-dimensional nano material such as a carbon nano tube, graphene, zinc oxide, molybdenum disulfide or tungsten disulfide. The platinum diselenide / Van der Waals heterojunction sensor realizes trace detection of dimethyl methylphosphonate (DMMP) at room temperature by using excellent performance of platinum diselenide and a synergistic effect of the Van der Waals heterojunction, has the advantages of low working temperature, high sensitivity, good stability, high response speed and the like, and can meet DMMP detection requirements in the fields of environmental monitoring, public safety and the like.

This invention provides a nitrogen-doped carbon composite cobalt-nickel diselenide nanocubic material, its preparation method, and its application in batteries. The invention involves dispersing cobalt salt, nickel salt, and hexadecyltrimethylammonium bromide in a solvent and mixing to obtain solution A; dispersing an organic ligand in the solvent and mixing to obtain solution B; pouring solution A into solution B and aging at room temperature to obtain a nanocubic precursor; then mixing with selenium powder and calcining under a protective atmosphere to obtain the CoNiSe2 / NC composite material. Compared with existing technologies, the synergistic effect of Co and Ni in this invention provides more active sites for the reaction and improves conductivity, resulting in a significant improvement in sodium-ion battery performance. Furthermore, the synthesis in this invention is performed at room temperature, simplifying the process; the porous structure design greatly improves the battery's cycle stability, extends its lifespan, and increases and stabilizes its capacity.

The invention discloses a lead-free copper-based self-lubricating composite material and a preparation method thereof, and relates to the technical field of self-lubricating bearing materials. The lead-free copper-based self-lubricating composite material comprises the following components in percentage by weight: 5%-10% of Sn, 0.5%-5% of Si, 1%-6% of selenide and the balance of Cu, and the selenide is selected from one or a combination of two of molybdenum diselenide and niobium diselenide. The comprehensive performance of the lead-free copper-based self-lubricating composite material is remarkably improved through material system design, the mechanical performance and service reliability are outstanding, the service cycle of a copper-based sliding bearing can be effectively prolonged, and compared with a traditional lead-containing material, the lead-free copper-based self-lubricating composite material has higher performance and environment friendliness and is suitable for being applied to bearings under extreme working conditions.

A novel organic diselenide composition comprises 1,2-bis(4-vinylbenzyl) diselane. The organic diselenide composition may be incorporated with one or more polymers through a chemical bonding process for utilization as an agent against infectious, disease-causing agents.

The application discloses a selenoglycoside compound and a synthesis method, and aims at a series of technical defects in the existing selenoglycoside synthesis technology, such as high reagent toxicity, strong irritability, poor stability, harsh reaction conditions, complicated operation, insufficient stereoselectivity, poor substrate universality and difficulty in industrial application, and provides a green and efficient selenoglycoside compound synthesis method with strong universality, which has remarkable beneficial technical effects. The core reaction substrate adopted in the application is a glycosyl selenosulfonate and a (hetero) aryl boronic acid, both of which are conventional reagents easy to obtain, have no irritating odor, and have excellent chemical stability and environmental tolerance, thereby avoiding the use of high-toxicity, high-irritability and low-stability reagents such as diselenide, selenol and glycosyl stannane in the traditional synthesis process from the source, greatly reducing the safety control cost and three-waste treatment pressure in the synthesis process, and meeting the development requirements of green chemistry.

This invention relates to a method for preparing and applying a ternary heterostructure nanosheet of tungsten diselenide / tin diselenide / tin monoselenide, belonging to the field of gas sensor technology. The invention discloses a ternary heterostructure nanosheet of tungsten diselenide / tin diselenide / tin monoselenide and its application as a sensing material in a highly selective and sensitive flexible NO2 gas sensor. The invention utilizes a liquid-phase growth method, using SnSe2 nanosheets, ammonium tungstate, and diphenyldiselenoether as raw materials, and varying reaction conditions such as temperature, reaction time, and raw material content to prepare the ternary heterostructure nanosheet of tungsten diselenide / tin diselenide / tin monoselenide. Subsequently, these nanosheets are sprayed onto interdigitated electrodes and dried to form a film, thus preparing a chemielectric resistive gas sensor capable of detecting low concentrations of nitrogen dioxide gas at room temperature. It not only possesses high sensitivity and selectivity but can also be applied to flexible NO2 gas sensing.

The application belongs to the field of electronic components, and particularly relates to a MCM-1A type high-frequency metal packaging mica capacitor. The capacitor is composed of a metal packaging shell, a core group in the shell is fixed by a silver-plated metal gasket, and the core group is composed of multiple pieces of white mica sheets printed with electrodes and silver-plated metal lead-out sheets alternately stacked. A dielectric topological insulator heterojunction composite nanomaterial is introduced into the silver-plated metal gasket. The material takes a bismuth diselenide nanosheet as a core, coats a barium strontium titanate shell through an atomic layer deposition process, and is modified through surface polymer coating. The composite nanomaterial effectively optimizes the interface characteristics and high-frequency conductivity of the electrode. The capacitor has a simple preparation process, is compatible with the existing production line, has lower loss and higher temperature stability at high frequency, and is suitable for high-frequency circuits.

The invention provides a preparation method and application of a spherical shell structure photo-thermal heterojunction filler self-repairing polyurethane anticorrosive coating, the coating is formed by mixing a spherical shell photo-thermal heterojunction and a polyurethane matrix according to the mass ratio of (0.01-0.2): 1, the spherical shell structure photo-thermal heterojunction takes nine-cobalt octasulfide as a core and manganese dioxide as a shell, and the polyurethane matrix is a polyurethane matrix. The heterojunction is prepared from nine cobalt octasulfide and manganese dioxide according to a molar ratio of 1: (10-30); the polyurethane matrix is formed by polymerizing polytetrahydrofuran or polydimethylsiloxane, diisocyanate, diselenide or disulfide according to the molar ratio of 0.15-0.85: 1: 0.15-0.85, key parameters such as reaction time, a heat treatment temperature interval and a curing time interval are further optimized, and the self-repairing performance under different illumination intensities is tested. The Q235 carbon steel is used as a substrate material, the prepared composite coating shows remarkable corrosion resistance in a 3.5% NaCl solution, and self-repairing performance is provided for the coating by introducing dynamic covalent bonds such as diselenide bonds and disulfide bonds; the photo-thermal performance of the coating is improved through controllable preparation of the photo-thermal heterojunction of the spherical shell structure; a coating formula with greatly improved performance is selected through a parallel experiment.

The invention discloses a metal nitrogen heterocyclic carbene covalent organic framework catalyst and a preparation method and application thereof. The catalyst contains a nitrogen heterocyclic carbene covalent organic framework structure connected by a carbon-carbon double bond and is anchored with a metal species coordinated with the nitrogen heterocyclic carbene active site. The preparation method comprises: subjecting a triimidazolyl organic compound to a quaternization reaction with bromoacetonitrile to prepare a tricyanomethylimidazolium monomer; dissolving the tricyanomethylimidazolium monomer and a trialdehyde monomer in an organic solvent, and constructing an imidazolium covalent organic framework connected by a carbon-carbon double bond through a Knoevenagel condensation reaction; dissolving the imidazolium covalent organic framework in an organic solvent, deprotonating it under alkaline conditions to release the nitrogen heterocyclic carbene active site, and then reacting with a metal active component to prepare the metal nitrogen heterocyclic carbene covalent organic framework catalyst. The catalyst is used for catalyzing the synthesis of symmetric diselenides from elemental selenium and aryl iodine, and has wide applicability and high efficiency.

The invention relates to a preparation method of a niobium diselenide lubricating film serving for current-carrying friction. The niobium diselenide lubricating film is prepared by adopting a radio frequency magnetron sputtering method. Sputtering gas is argon, a sputtering target material is niobium diselenide, the niobium diselenide thin film which is compact in structure and has good mechanical performance, electrical performance and lubricating performance is prepared by changing argon flow and substrate negative bias pressure, stable lubrication in 100 thousand cycles can be achieved in the atmospheric environment, and the friction coefficient is 0.08. Under a current-carrying friction working condition, compared with a traditional molybdenum disulfide film, the contact voltage is only 1 / 4, and the wear rate is reduced by more than half. The technology can be widely applied to antifriction and wear-resistant treatment of electric contact sliding parts in the fields of aerospace, electric power systems, semiconductor manufacturing and the like.

The invention discloses a preparation method of a covalent triazine framework material constructed by a metal disulfide alkene complex and an all-solid-state battery application of the covalent triazine framework material. A monomer M1 and a monomer M2 are subjected to a reaction to obtain the metal-based covalent triazine framework material, M1 is bis [1, 2-bis (4-formylbenzene) vinyl-1, 2-dithioene] M (M is one of metal nickel, cobalt, zinc and copper), and M2 is 2, 4, 6-tri (4-aminophenyl)-1, 3, 5-triazine. The obtained metal-based covalent triazine framework material is used as an artificial solid electrolyte interface layer for protecting a sulfide all-solid-state lithium metal negative electrode, so that side reaction between the lithium metal negative electrode and a solid electrolyte can be effectively inhibited, growth of lithium dendrites can be inhibited, uniform deposition of Li < + > can be induced, and the service life of the lithium metal negative electrode is prolonged. Therefore, the high-performance all-solid-state lithium metal battery is obtained.

The invention relates to the technical field of high polymer materials, and discloses a transparent invisible orthodontic appliance material with an antibacterial function and a preparation process thereof, and the transparent invisible orthodontic appliance material is characterized in that a selenium-containing monomer, a fluorine-containing amphoteric monomer and a sacrificial metal coordination network are introduced into a thermoplastic polyurethane main chain. In the preparation process, a hot shear field of melt extrusion is used for driving fluorine-containing amphoteric groups to segregate on the surface, and a wet hydrophilic anti-adhesion layer is formed; a physical cross-linked network is constructed through metal coordination, modulus compensation is provided, and the material is endowed with mechanochemical response characteristics. When the appliance is stressed, the sacrificial coordination bond is broken to release metal ions, the diselenide bond is catalyzed to efficiently generate active oxygen, and antibacterial enhancement of a stressed area is realized. The material disclosed by the invention has the synergistic functions of high transparency, excellent obdurability, microcrack self-repairing and anti-adhesion intelligent sterilization, and effectively solves the problems that the invisible appliance is easy to breed bacteria and the mechanical property is degraded.

The invention relates to the technical field of nano medicines, and discloses an ATP / cerium coordination polymer nano regulator as well as a preparation method and application thereof. The invention relates to an ATP / cerium coordination polymer nano regulator. The invention relates to a self-assembly hydrogel which is prepared from raw materials including cerous nitrate (III), adenosine-5 '-disodium triphosphate, phospholipid polyethylene glycol amino, SS31 peptide and a diselenide cross-linking agent through a self-assembly and cross-linking method, can effectively remove ROS (reactive oxygen species) in an inner ear and protect cells from oxidative stress injury, thereby protecting auditory cells and improving the quality of the inner ear. The traditional Chinese medicine composition has the effect of treating hearing loss caused by oxidative stress induced by noise, can be used for treating hearing loss through middle ear cavity local administration, is simple in preparation method and mild in reaction condition, and can realize large-scale production. Cascade catalysis of cerium (III) and cerium (IV), ATP (adenosine triphosphate) energy supply and a nano system of a selenium biological material are utilized, and a novel method is provided for treating noise-induced hearing loss.

The application provides a synthesis method of L-selenium-methyl selenocysteine, which comprises the following steps: mixing dimethyl diselenide with sodium borohydride, then adding a sodium hydroxide solution to react, to obtain a sodium methyl selenide solution; preparing 3-chloro-L-alanine methyl ester hydrochloride, stirring the prepared 3-chloro-L-alanine methyl ester hydrochloride with the sodium methyl selenide solution to react; acidifying the solution after the stirring reaction, then extracting, removing impurities, heating the water phase, and reducing pressure distillation to obtain solid crystals; using methanol to extract the solid crystals twice, then adding triethylamine to stir and crystallize, to obtain L-selenium-methyl selenocysteine solid crude product; hydrating the L-selenium-methyl selenocysteine solid crude product, then recrystallizing to obtain L-selenium-methyl selenocysteine solid; the L-selenium-methyl selenocysteine synthesized by the application has the advantages of simple process route, mild conditions, high purity and high yield.

The invention provides an environment-friendly flame-retardant new energy charging pile cable which comprises a conductor, an insulating layer, an inner sheath layer and an outer sheath layer. The insulating layer is prepared from 25 to 35 parts of hydrogenated styrene-butadiene block copolymer, 10 to 20 parts of borazine modified polybenzoxazine, 6 to 10 parts of antimony sulfide, 7 to 13 parts of MoS2 quantum dot-PI nanofiber, 5 to 10 parts of hydroxyapatite, 3 to 7 parts of copper hexacyanoferrate, 7 to 13 parts of PEEK grafted TiO2 nanoparticle, 4 to 8 parts of benzoxazine modified BN nanotube and 1 to 5 parts of silane modified melamine; the inner sheath layer comprises 35 to 40 parts of ethylene-ethyl acrylate copolymer, 8 to 12 parts of tungsten diselenide, 10 to 15 parts of aluminate modified ZB microcapsule, 6 to 10 parts of nano tantalum carbide, 10 to 15 parts of PLGA modified montmorillonite, 6 to 10 parts of BMI grafted carbon fiber and 2 to 6 parts of nano ZnO-Ag antibacterial agent; and the outer sheath layer comprises 35 to 45 parts of a PEEK-PTFE blend, 5 to 10 parts of niobium diselenide, 10 to 15 parts of modified nano clay, 4 to 8 parts of molybdenum ditelluride, 10 to 20 parts of zinc hydroxystannate, 3 to 7 parts of microencapsulated DCPD and 2 to 6 parts of a vulcanizing agent. The cable has the advantages of environmental protection, flame retardance, wear resistance, aging resistance and the like.

The present invention provides a hydrogel for comprising a biodegradable polyphosphazene polymer, a radiation-sensitive diselenide cross-linker; and one or more payloads releasably loaded within the hydrogel. The present invention further provides methods for radiosensitizing target tissues such as tumors and providing sustained delivery of therapeutics triggered by irradiation. In another aspect, the present invention provides a method that includes: introducing the hydrogel, as describes herein, adjacent to malignant or marginal tissue; and administering radiation to the hydrogel, thereby disrupting the selenocystamine cross-linkers and releasing the one or more payloads.

The application discloses a preparation method of germanium diselenide and belongs to the technical field of compound preparation. The preparation method of germanium diselenide provided by the application comprises the following steps: mixing germanium powder screened and selenium powder screened and ball milling, then heating and reacting in an inert gas environment, crushing after removing the surface attachments of the heating and reaction product, and heat-insulating and reacting in the inert gas environment, so that golden yellow crystalline germanium diselenide can be obtained. The obtained germanium diselenide is high in purity, free of segregation, and low in loss, namely, high in yield. Moreover, the preparation method provided by the application is simple in operation, does not need special equipment, and is beneficial to practical production and application.

The invention discloses a method for synthesizing selenocyclopentene by electrochemical catalysis of cyclization reaction of terminal alkyne, acrylate and diselenide [3 + 2], and belongs to the technical field of organic synthesis.The method comprises the steps that the terminal alkyne, allyl dimethyl ester and diselenide serve as raw materials, cheap ferrocene serves as a redox catalyst under the electrochemical condition, and the selenocyclopentene is synthesized through the cyclization reaction of the terminal alkyne, the acrylate and the diselenide [3 + 2]; the selenium-containing cyclopentene skeleton is efficiently constructed. According to the method for synthesizing selenocyclopentene through the cyclization reaction of terminal alkyne, acrylate and diselenide [3 + 2] through electrochemical catalysis, the reaction condition is mild, no additional oxidizing agent is needed, the substrate applicability is wide, the functional group compatibility is good, and the target product can be obtained with the medium to excellent yield.

The application provides a high-inductance copper-iron co-fired inductor, which comprises soft magnetic metal powder, a copper conductor and nanocrystalline strip material, the copper conductor is connected perpendicularly with the nanocrystalline strip material and is embedded in the soft magnetic metal powder, and the copper conductor extends out of the soft magnetic metal powder at both ends; the soft magnetic metal powder comprises mixed powder of different particle size gas atomized iron-nickel-molybdenum powder, a passivating agent, a coating agent and a lubricant; the passivating agent is a mixed solution of oxalic acid and nitric acid; the coating agent is a mixture of fluorosilicon resin, titanium trifluoride, aluminum trifluoroacetyl acetonate and nanometer barium titanate acetone solution; the lubricant is a mixture of gas phase aluminum oxide and niobium diselenide; the thickness of the nanocrystalline strip material is 1-1.5 um, and the width is 2-4 mm. The application uses the gas atomized iron-nickel-molybdenum powder with the highest magnetic permeability in the soft magnetic metal powder, so that the inductance value of the inductor reaches the maximum value, and the gas atomized iron-nickel-molybdenum powder has very low loss and excellent stability, so that the inductor has good loss performance and excellent reliability.

The application discloses a kind of high selectivity β-triazole (β-triazole trifluoromethyl, β-triazole ketone, β-triazole thio, β-triazole selenide) Derivative and its synthesis method and application, with triazole compound, alkyl compound / aldehyde / dithioether / diselenide and styrene as raw material, in oxidant, additive and organic solvent, through one step reaction can high selectivity, high yield product is obtained.The method of the application has the advantages of good selectivity, mild reaction condition, high yield, simple and safe operation and high efficiency etc.The β-triazole ketone derivative compound involved in the application is a kind of new structure, has good anti-osteosarcoma activity, biological activity analysis shows that part of compounds can reach 99% inhibition rate to osteosarcoma (OS) cell line 143B, MNG / HOS and SJSA-1 at 10 μM concentration.Therefore, the compound can be used as important pharmaceutical and chemical intermediates, and has wide application prospect in the field of medicine.

The application discloses a selenium-based pyrrolopyridazine compound and a preparation method and medical application thereof. The structure of the compound is shown as formula (I). The preparation method of the compound is as follows: 1-amino pyrrole, aryl formaldehyde, diaryl diselenide and disubstituted acetylene are used as raw materials in an organic solvent, under the protection of nitrogen, in the presence of a rhodium catalyst and a copper salt, and heating reaction can obtain the selenium-based pyrrolopyridazine compound. The method has the advantages of high functional group tolerance and simple operation. In addition, the activity test results show that the selenium-based pyrrolopyridazine compound prepared by the application exhibits significant inhibitory activity on JAK1 and JAK3 kinases, has a good clinical development prospect, and can be used for preparing a medicine for preventing and / or treating rheumatoid arthritis.

The application provides a ferrous diselenide rod-shaped nanoflower nitrogen-doped carbon material and a preparation method and application thereof, and belongs to the technical field of battery materials. The prepared iron selenide presents a nanoflower structure composed of nanorods, and an outer layer is covered by a nitrogen-doped carbon shell, and is a kind of self-assembled nanoflower composite material. The nanoflower structure increases the specific surface area of the material, provides abundant active sites for catalysis, the nitrogen-doped carbon shell enhances the physical confinement of polysulfides and the transmission of electrons, there is a strong chemical bond between FeSe2 and polysulfides, which can effectively anchor polysulfides, and can accelerate the catalytic conversion of polysulfides and relieve the shuttle effect. The lithium-sulfur battery using the material as a positive active material has excellent cycle stability and high sulfur loading.