The invention provides a hierarchical protection control system facing a regional power grid. The hierarchical protection control system comprises an in-situ level protection device, a substation area protection control system and a wide area protection control system, wherein the in-situ level protection device is configured according to a traditional protection scheme and adopts a direct sampling direct trip mode or a direct sampling network trip mode; the substation area protection control system is configured according to substations or voltage classes, utilizes an information sharing advantage to improve the backup protection performance, realizes protection functions of backup protection, redundancy protection, failure protection, and the like, and control functions of spare power automatic switching, low-frequency and low-voltage load shedding, and the like, and adopts a network sampling network trip mode; and the wide area protection control system is configured according to areas, realizes functions of wide area backup protection, self-adaptive adjustment of protection fixed values, low-frequency and low-voltage load shedding, power grid state evaluation, safety pre-warning, and the like, and realizes the interaction and the sharing of information of intelligent transformer substations in the areas through a wide area communication net. The hierarchical protection control system has the advantages that the reliability and the selectivity of relay protection can be improved on the basis that protection configuration of the existing power grid is not changed, so high requirements of power grid interconnection, new energy access, and the like on relay protection are satisfied.