A comprehensive monitoring system for electric power system transformers comprises an IEC61850-based unified modularized CPU (central processing unit) hardware platform, a sensor, a system terminal, at least one of nine monitoring logical devices, and further comprises an expert analysis system, including a thermal management mathematical model and an oil and gas analysis mathematical model, wherein by configuring and starting software, a function for monitoring corresponding LDs (logical device) which are independent of one another is achieved; and by performing independent effective data acquisition on the transformers respectively, and integrating and processing the data by the CPU, the electric power system transformers are comprehensively monitored in a configurable way. The comprehensive monitoring system for the electric power system transformers is convenient and flexible in application; current situations of repeated data acquisition, and shortage of data integration, data processing, information exchange and information sharing are changed; conversion from the conventional mechanism-based timed maintenance to the state-based preventative maintenance is facilitated; the maintenance cost is obviously saved; service lives of the transformers are prolonged; and a customer can obviously reduce the purchase cost and the management cost.