22 results about "Disulfide compound" patented technology

The phenylenediamine-based antioxidant is used as a substitute for 6PPD, while improving scorch resistance and heat aging resistance. [Solution] The rubber composition according to the embodiment comprises a rubber component, a phenylenediamine-based antioxidant represented by the following formula (1), and a thiuram disulfide-based vulcanization accelerator. In formula (1), R 1 and R 2 Each of these independently represents a hydrocarbon group having 6 or more carbon atoms, however, R 1 and R 2 Except when it is a combination of a phenyl group and a 1,3-dimethylbutyl group. [Formula 1] JPEG2026103949000010.jpg42129

This invention discloses a method for preparing high-purity Si-75, comprising: S1, adding sodium sulfide, sulfur, and deionized water in a molar ratio of 1:(1.0~1.1):(5~8) to a reaction vessel, adding a buffer, and reacting at 80~90℃ for 1~2h; S2, adding a phase transfer catalyst and a hydrolysis inhibitor to the system, adding γ-chloropropyltriethoxysilane dropwise, and reacting at 85~95℃ for 3~5h, allowing the mixture to stand and separate into layers after the reaction, to obtain an organic phase; S3, subjecting the organic phase to short-path distillation and then filtering to obtain high-purity Si-75. Compared with existing technologies, this invention uses a phosphorus-free buffer system, which simplifies waste treatment. It uses water as the reaction medium and does not use large amounts of organic solvents, making it suitable for continuous industrial production. By adding hydrolysis inhibitors, hydrolysis can be effectively prevented during the reaction, increasing safety. The short-path distillation method provides high purification efficiency and can quickly remove impurities. The product has a disulfide content of ≥98.5% and a color of 0 (Gardner color number), which is of great significance to the light-colored rubber industry.

The present application relates to the technical field of medicine, in particular to a kind of siRNA eye drop for penetrating mucus barrier and cell barrier and preparation method thereof.Innovative development side chain guanidino group-containing polydisulfide delivery carrier is used in the present application, through the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on mucin, tear film retention and efficient penetration are realized, and cationic polydisulfide is quickly adsorbed on the surface of negative charged cell membrane by electrostatic interaction, the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on cell membrane is used, and endocytosis is used to quickly penetrate tight junction cell layer.

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

This invention relates to a triboelectric nanogenerator and its preparation method, belonging to the technical field of triboelectric nanogenerators. The preparation method includes the following steps: S1, dispersing styrene-ethylene-butene-styrene block copolymer, polyvinylidene fluoride, and MXene nanomaterials in a mixed solvent to obtain a negative friction layer spinning solution; S2, using dynamic pattern-induced multi-material nanofiber electrospinning technology, forming a negative friction layer from the negative friction layer spinning solution; S3, dispersing thermoplastic starch, sodium carboxymethyl cellulose, plasticizer, bis(2-hydroxyethyl) disulfide, and dithiothreitol in water to obtain a positive friction layer film-forming solution; S4, forming a positive friction layer from the positive friction layer film-forming solution; S5, bonding the micro-nano structures of the positive and negative friction layers face-to-face to obtain the triboelectric nanogenerator. This generator combines high output, long lifespan, and flexibility, and can be adapted to diverse scenarios such as wearable electronics, industrial high-temperature sensing, and environmental mechanical energy harvesting.

This invention relates to a polymerizable disulfide, its preparation method, and its uses, belonging to the fields of polymer chemistry and photopolymerization. It is proposed based on the significant volume shrinkage inherent in LED free radical photopolymerization. The beneficial effects of this invention are that the disclosed polymerizable disulfide compound can reduce the volume shrinkage of 405nm LED light-induced free radical photopolymerization, while also possessing initiation and polymerization properties. Furthermore, this disulfide can improve the heat resistance of photocurable materials, showing great application potential in the field of LED photopolymerization.

This invention belongs to the field of polymer materials technology, and specifically relates to a PET composite material, its preparation method, and its application. By weight, the raw materials for preparing the PET composite material of this invention include 70-95 parts of polyethylene terephthalate, 0-15 parts of polybutylene terephthalate, 3-10 parts of toughening agent, and 0.2-1 parts of anti-crystallization agent; the anti-crystallization agent includes at least one of polyethylene glycol, polyacrylamide, and alkylphenol disulfide oligomers. The PET composite material of this invention has high transparency, fully displaying the color of the internal low-smoke halogen-free cable, with no visual color difference. It does not exhibit significant discoloration even after long-term exposure to outdoor light, greatly expanding its outdoor applications. The material has very low water absorption and good barrier properties, thus effectively maintaining the electrical performance of the cable.

An oral care composition is provided and includes a hops extract, where the hops extract includes dimethyl disulfide, a stannous ion source, and a stabilizing system including a Michael acceptor. The Michael acceptor has an alpha, beta-unsaturated carbonyl group. The alpha, beta-unsaturated carbonyl group can include an aldehyde, a ketone, a cyclic ketone, or a combination thereof.

The application relates to a kind of dynamic crosslinking polyethylene and its preparation method and application, and it relates to the technical field of polymer materials;A kind of dynamic crosslinking polyethylene, ethylene copolymer containing MAH unit 94-100 parts, disulfide bond monomer 0.3-5 parts;The disulfide bond monomer is polyamino disulfide compound;The MAH content in the ethylene copolymer containing MAH unit is greater than or equal to 2.8wt%.The dynamic crosslinking polyethylene, by the reaction of ethylene copolymer containing MAH unit and disulfide bond monomer, grafts the dynamic crosslinking disulfide bond group on PE segment, forms crosslinking network in polyethylene system, which can greatly improve tensile strength and storage modulus performance;Meanwhile, the crosslinking network of disulfide bond can occur reversible fracture and recombination under certain conditions, so that polyethylene can be recycled and reused again, and the recycled polyethylene still has excellent tensile strength.

Optical resin material, characterized in that the raw material comprises a polythiol composition and an isocyanate, wherein the polythiol composition comprises tetrakis(3-mercaptopropionic acid)pentaerythritol ester and tetrakis(3-mercaptopropionic acid)pentaerythritol ester disulfide substituent, wherein the structural formula of the tetrakis(3-mercaptopropionic acid)pentaerythritol ester disulfide substituent is as shown in formula 1: wherein the mass ratio of tetrakis(3-mercaptopropionic acid)pentaerythritol ester disulfide substituent to tetrakis(3-mercaptopropionic acid)pentaerythritol ester is 1:181 to 10000.

This invention discloses a double-bond-terminated cationic organosilicon waterborne polyurethane, its preparation method, and an anti-fogging and sterilizing hydrogel and coating, belonging to the field of medical materials technology. A double-bond-terminated cationic organosilicon waterborne polyurethane is obtained by reacting triethylene glycol, 3-dimethylamino-1,2-propanediol, hydroxypropyl silicone oil, isophorone diisocyanate, chain extender bis(2-hydroxyethyl) disulfide, and end-capping agent hydroxyethyl methacrylate. A hydrophilic-hydrophobic heteropolymer network is constructed, achieving rapid water spreading and anti-swelling properties. It possesses contact-active antibacterial and self-cleaning properties and forms a stable Si-O-Si covalent interface to achieve excellent substrate adhesion. The prepared coating shows broad application prospects in the functionalization of optical device surfaces, laying a reliable material foundation for the development of safer and more durable medical optical components.

The present invention relates to a method for preparing a separation membrane comprising: a) a step of preparing transition metal(s) sulfide nanoparticles, selected from Mo, V, and W, including a thermal decomposition step of at least one organic or mineral precursor of the transition metal and at least one sulfur precursor, and / or at least one organic precursor of both the transition metal and sulfur, in the presence of at least one organic stabilizing agent to obtain nanoparticles in the form of monolayers; b) a step of depositing said nanoparticles prepared in step a) as a selective layer on a support membrane, in particular by direct filtration of a solution containing said nanoparticles onto said support membrane, or by immersing the support membrane in a solution containing said nanoparticles. Figure for the abstract: Fig. 1

The application discloses a method for constructing asymmetric sulfenyl sulfonate by electrochemical oxidation in an aqueous phase, which successfully realizes the construction of asymmetric sulfenyl sulfonate by electrochemical oxidation-nucleophilic substitution reaction in an aqueous phase. The reaction uses sodium sulfinate and disulfide as raw materials to efficiently synthesize asymmetric sulfenyl sulfonate compounds, and for the first time realizes the dual function of water as a solvent and a reactant. The method is carried out at room temperature, has mild reaction conditions, a simple process and easy operation, and does not need to use organic solvents, metal catalysts and chemical oxidants, thereby reducing the generation of chemical waste reagents and being more friendly to the environment. In addition, the antibacterial performance of the sulfenyl sulfonate is evaluated, and it is found that S-isopropyl 4-methyl benzene sulfenyl sulfonate shows good antibacterial activity on staphylococcus aureus and streptococcus mutans, which indicates that the method has a wide application market.

This invention relates to a leptomycin derivative of formula (I): Wherein: • Ra and R a are H or a linear or branched C1-C20 alkyl; • R17 is alkyl optionally substituted by OR, CN, NRR, perfluoroalkyl; • R9 is alkyl optionally substituted by OR, CN, NRR, perfluoroalkyl; • X is -NR-; • Y is a linear or branched C1-C20 alkyl; • n is 0: • T represents a thiol protecting group such as Ac, R1 or SRI, wherein R1 represents H, methyl, a linear or branched C1 -C20 alkyl; having a moiety, such as a sulfide or a disulfide, thatcan conjugate to a cell binding agent as an antibody. The therapeutic use of such leptomycin derivative conjugates is also described: such conjugates being able to deliver cytotoxic leptomycin derivative to a specific cell population in a targeted fashion.

This invention belongs to the field of lubricating materials technology, specifically relating to a modified disulfide-based composite film, its preparation method, and its application. The modified disulfide-based composite film of this invention comprises a matrix and a first metal oxide and a second metal oxide dispersed in the matrix; the first metal oxide includes one or more of WO3, TiO2, CaO, MoO3, Ta2O5, In2O3, Nb2O5, ZrO2, Cr2O3, and HaO2; the metal element in the second metal oxide is the same as that in the matrix. Introducing the first metal oxide into the matrix effectively refines the disulfide crystal particles and passivates active sites, thereby affecting its sensitivity to humid and hot conditions; through humid and hot storage treatment, the second metal oxide particles can be generated in situ, prompting them to transform the shear sliding of the WS2 film into a "rolling-sliding" cooperative mode during friction, reducing the coefficient of friction and improving its tribological properties.

The application discloses a normal-temperature self-healing polyurethane modified asphalt and a preparation method thereof, and belongs to the technical field of road engineering materials. The modified asphalt comprises a bio-based dynamic polyurethane modifier, which is prepared by reacting isocyanate, a bio-based polyol mixture (castor oil-based polyol and PPC) and amine-containing aromatic disulfide. The innovation lies in that the activated alpha-methylene (active alpha-hydrogen) in the PPC chain segment is used as a hydrogen bond donor to form a dynamic C-H...O hydrogen bond network (alpha-hydrogen enhanced network) with the hard segment carbonyl. The network has low bond energy and high dynamicity, and cooperates with the dynamic disulfide bond, so that the material can realize efficient self-healing at 25 DEG C room temperature without external stimulation, and the self-healing efficiency can reach about 92%. The preparation method comprises the steps of synthesizing a polyurethane prepolymer, introducing a disulfide bond through chain extension, and then mixing the modifier with molten asphalt at high speed. The application realizes room-temperature rapid self-healing, and has excellent mechanical properties and environmental protection characteristics.

Provided is a pharmaceutical composition for treating burns containing transition metal dichalcogenide (TMD) as an active ingredient.

To provide a method for producing oligonucleotides that can suppress the formation of by-products. [Solution] A method for producing an oligonucleotide having a phosphate ester bond by oxidizing an oligonucleotide precursor having a phosphite ester bond or a phosphonic acid ester bond with an oxidizing agent, wherein the oxidizing agent is a compound represented by formula (I) (excluding 2,2-dipyridyl disulfide) (the definition of the symbols in the formula is as described in the specification). JPEG2026110729000086.jpg844

This application discloses a method for synthesizing thiazolinyl dithioalkyl sulfonate, relating to the field of chemical synthesis. The method includes the following steps: mixing 2-mercaptothiazoline, polydithioalkyl sulfonate, and a solvent to obtain a mixture; adding an alkaline catalyst to the mixture; reacting and then separating and purifying to obtain the thiazolinyl dithioalkyl sulfonate; the general structural formula of the polydithioalkyl sulfonate is: ; where M is an alkali metal ion and n is an integer from 1 to 5. This invention uses 2-mercaptothiazoline and polydithioalkyl sulfonate as raw materials, and performs an alkaline-catalyzed thiol / disulfide exchange reaction. Through a precipitation-crystallization purification process, it is beneficial to improve the yield (≥90%) and purity (≥98%) of the synthesized thiazolinyl dithioalkyl sulfonate. It has advantages such as convenient process, good safety, low waste, high atom economy efficiency, and ease of scale-up production.

The present invention provides a composition having an action to enhance adrenomedullin gene expression. One or more embodiments of the present invention relate to a composition for enhancing adrenomedullin gene expression containing a TRPV1 agonist and a TRPA1 agonist as active ingredients. The TRPV1 agonist can be, for example, at least one selected from capsaicin, 6-shogaol, 6-gingerol and piperine. The TRPA1 agonist can be, for example, at least one selected from allyl isothiocyanate, cinnamaldehyde, diallyl disulfide, ASP7663 and oxylipin.

The invention relates to a pre-sulfurization process for hydrocarbon treatment catalysts, carried out in the presence of an ammonium disulfide solution. The invention is characterized in that a sulfur additive, namely DEODS (diethanol disulfide), is used in conjunction with the ammonium disulfide.

The application discloses a new type of composite steel pipe combined with plastic lining and coating and a preparation method, and relates to the technical field of composite pipe manufacturing. The composite steel pipe comprises a steel pipe base body, a polyethylene outer layer and a glue layer arranged between the steel pipe base body and the polyethylene outer layer. The glue layer comprises a dynamic cross-linking polymer network formed by cross-linking of an epoxy resin and bis-(4-aminobenzyl) disulfide, wherein the addition amount of the bis-(4-aminobenzyl) disulfide is 18.5% to 24.5% of the mass of the epoxy resin, and the two are matched in an epoxy group to amine hydrogen group equivalent ratio of 0.9:1 to 1.1:1. The application further discloses a preparation method thereof. Through specific forming and high-temperature maintaining processes, the reversible exchange of the dynamic disulfide bond in the network is activated. The application utilizes the stress self-adaptive release mechanism of the dynamic covalent bond, which is helpful to relieve the aggregation of the interface residual internal stress and improve the interface bonding stability of the composite pipe under long-term service and cold and hot cycles.