59 results about "Phthalaldehyde" patented technology

The invention provides an antibacterial cationic hydrogel adhesive and a preparation method thereof. The antibacterial cationic hydrogel adhesive is prepared from the following raw materials: polyphenol grafted epsilon-polylysine; the end group of the four-arm polyethylene glycol is phthalic dialdehyde; the polyphenol grafted epsilon-polylysine polymer has a structure as shown in a formula I or a formula II. The hydrogel adhesive contains epsilon-polylysine, so that the hydrogel adhesive can resist bacteria for a long time, and drug resistance is avoided; the grafted polyphenol functional group can effectively remove excessive free radicals and has an anti-oxidation function, so that wound healing is promoted, and tissue adhesiveness can be enhanced; and the tissue adhesiveness is provided by utilizing the rapid cross-linking gel formation of o-phthalaldehyde-amine.

The invention discloses o-phthalaldehyde disinfectant concentration detection test paper and a preparation method thereof.The preparation method comprises the steps that S1, a color developing agent, a color developing accelerant and a stabilizer are dissolved in purified water, a solution A is prepared, and the color developing agent accounts for 0.1-10 wt%, the color developing accelerant accounts for 0.1-10 wt%, and the stabilizer accounts for 0.1-10 wt%; s2, the filter paper is completely soaked in the liquid A for 1-2 min, and the filter paper is dried after being completely soaked; s3, uniformly dissolving a film-forming agent in purified water to prepare 0.1-10wt% of a solution B; s4, immersing the filter paper dried in the step S2 into a solution B, continuing for 10-30s, and then drying; and S5, cutting the dried filter paper, and pasting the cut filter paper on a substrate paperboard to obtain the phthalic dicarboxaldehyde disinfectant concentration detection test paper. The test paper for detecting the concentration of the o-phthalaldehyde disinfectant has the advantages that the validity period is as long as 2 years, the color development effect is stable, and the concentration of the o-phthalaldehyde disinfectant can be effectively and accurately reflected.

The invention discloses a Pd-coated S-COF catalyst for a reaction of preparing styrene through phenylacetylene hydrogenation as well as preparation and application of the Pd-coated S-COF catalyst. The Pd (at) S-COF catalyst comprises a covalent organic framework carrier S-COF and Pd nanoparticles, the covalent organic framework carrier S-COF is an imine bonded covalent organic framework prepared by using 2, 4, 6-tri (4-aminophenyl)-1, 3, 5-triazine and 2, 5-dimethyl thioether-1, 4-phthalaldehyde as raw materials, and the Pd nanoparticles are used for modifying Pd nanoparticles. The Pd nano-particles are encapsulated in pore channels of the S-COF and are loaded on the surface of the S-COF. The invention provides an application of the Pd-coated S-COF catalyst in a reaction for preparing styrene through phenylacetylene hydrogenation, and high phenylacetylene conversion rate and high styrene selectivity can be realized within a short reaction time.

The invention relates to the technical field of carbon material preparation, in particular to phenolic resin-based porous carbon and a preparation method thereof. The core of the preparation method of the phenolic resin-based porous carbon is that the mass ratio of phenolic aldehyde to phenolic aldehyde is optimized (1: (1-1.2)) to ensure sufficient crosslinking, and an amine catalyst is selected to reduce metal residues; meanwhile, terephthalaldehyde is introduced as a cross-linking accelerant, so that the bridging density and thermal stability of a resin network are effectively enhanced, and structural collapse is inhibited in subsequent carbonization; a sectional type carbonization process is further adopted, and the carbon skeleton is preserved by controlling the heating rate. According to the method, the carbonization yield is finally and successfully improved to 58% or above (improved by 15%-20% compared with that of a traditional method), the ash content is remarkably reduced (smaller than or equal to 0.2%), and an excellent material with a small mesoporous structure (the average pore diameter ranges from 2 nm to 10 nm) and a high specific surface area (larger than or equal to 1500 m < 2 > / g) is obtained.

The invention belongs to the technical field of disinfectants and discloses a high-level disinfectant and a preparation method thereof.The high-level disinfectant is prepared from, by mass, 0.1%-3% of phthalic dicarboxaldehyde, 0.2%-0.8% of chelating agent, 2%-5% of penetrating agent, 0.3%-2% of modified starch, 1%-2% of acrylic polymer, 0.1%-0.3% of single-chain quaternary ammonium salt, 0.1%-0.3% of double-chain quaternary ammonium salt, 0.4%-5% of corrosion inhibitor and the balance purified water. Modified starch and polyacrylic acid are fully dissolved in a high-temperature stage, molecular chains are fully expanded, more active sites are exposed, and then the temperature is gradually reduced, so that the molecular chains are orderly arranged, a compact and uniform network structure is formed, and effective release of bactericidal components is ensured. Meanwhile, the single-chain quaternary ammonium salt and the double-chain quaternary ammonium salt are complementary through membrane destruction and internal destruction respectively and have a synergistic effect with the o-phthalaldehyde, so that the sterilization effect is remarkably improved.

Ortho-phthaldehyde is introduced as a versatile moiety to imbue ultraviolet-absorbing or visible chromophore compounds bearing this moiety with the capability to remain locally retained in the epidermis for days to weeks by virtue of a safe, efficient, and reagent-free reaction that bonds the ortho-phthalaldehyde moiety covalently to endogenous proteins in the stratum corneum of skin tissue by forming a phthalimidine linkage with primary aliphatic amines such as lysine and N-terminal residues, when applied topically on human or other mammalian skin from a suitable liquid, gel, or emulsion containing the ortho-phthalaldehyde compound with cosmetically acceptable alcohols, oils, and modifiers.

The invention relates to the technical field of o-phthalaldehyde disinfectants, and discloses o-phthalaldehyde disinfectant preparation equipment and a preparation method thereof.The o-phthalaldehyde disinfectant preparation equipment comprises a base, a processing barrel fixedly connected to the top end of the base, a liquid drainage pipe fixedly connected to the bottom end of the processing barrel in a penetrating mode, and a water injection pipe fixedly connected to the side wall of the processing barrel in a penetrating mode. A gear is driven by a toothed plate to intermittently rotate, so that the gear controls a baffle through a special-shaped plate to intermittently seal an atomizing mixing barrel, and a mixed solution in the atomizing mixing barrel intermittently flows into a connecting barrel; the problem that the solution in the atomization mixing cylinder cannot flow completely in the process of flowing into the connecting cylinder at a time is avoided, meanwhile, the content of the mixed solution flowing into the connecting cylinder every time is controlled through the concentration detection controller, and then the concentration of the phthalic dicarboxaldehyde disinfectant can be controlled according to needs; furthermore, the flexibility of preparing the phthalic dicarboxaldehyde disinfectant by the equipment is improved.

The invention belongs to the field of synthesis and preparation of Schiff base single crystals, and particularly relates to a p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal and a preparation method thereof. The p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is a Schiff base formed by condensation of one molecule of p-phthalaldehyde and two molecules of 4-amino-3-methylphenol, and is a completely symmetrical bis-Schiff base, and the molecular structural formula of the p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is C22H20N2O2. The compound has good optical performance, can be used as a reaction intermediate product for synthesis of epoxy resin, and has important significance for research of high-thermal-conductivity epoxy resin; and the new single crystal can show excellent photoelectric properties, thermal stability or magnetism, and promotes the innovation of photoelectric devices or spintronics devices.

This invention relates to a method for preparing a β-cyclodextrin functionalized covalent organic framework composite material. The method involves an aldehyde-imine condensation reaction between the aldehyde groups on 2,3,4-trihydroxybenzaldehyde and p-phthalaldehyde and the amino group on hepta(6-amino-6-deoxy)betacyclodextrin to construct a β-CD-COF layer. This one-step method produces a β-cyclodextrin covalent organic framework composite material that exhibits excellent enrichment capacity for phosphopeptides, facilitating purification and extraction. It also shows promising application prospects in mass spectrometry detection and exosome separation.

The invention discloses an imine type COFs (Covalent Organic Frameworks) material for adsorbing gold as well as a preparation method and application thereof, and belongs to the technical field of precious metal recovery. The preparation method specifically comprises the following steps: (1) mixing terephthalaldehyde and acetic acid, and stirring to obtain a suspension; (2) mixing N1, N1 '-(1, 4-phenylene) bis (N1-(4-aminophenyl) benzene-1, 4-diamine and deionized water, dropwise adding the mixture into the suspension, and stirring the mixture; and (3) after the reaction is finished, collecting the generated precipitate, washing and drying to obtain the product. The Schiff base type COFs material with high thermal stability, high specific surface area and good crystallinity is synthesized by pre-activating an aldehyde monomer and an amine monomer with acetic acid in a room-temperature aqueous solution by utilizing the oxidation resistance characteristic of hydroxyl and the dynamic repairing capacity of an imine bond, and the adsorption material has the advantages of high adsorption capacity, high stability and high accuracy, and can be used for preparing the COFs material with high specific surface area and good crystallinity. And the preparation method is green, simple, convenient, universal and efficient, and realizes accurate adsorption of single metal ions under the coexistence of multiple metal ions.

The application belongs to the technical field of ship coating, and particularly relates to a self-repairing ship antifouling coating and a preparation method thereof. 2+ The preparation steps comprise the following steps: polyether amine and 1-pyrene butyric acid are reacted in an ethanol and water mixed solvent to obtain pyrene-based hyperbranched polyether amine; the pyrene-based hyperbranched polyether amine is reacted with p-phthalaldehyde modified by 2,6-diaminopyridine to form a dynamic polymer; a complex solution of ethylenediaminetetraacetic acid and Mg 2+ is added to the dynamic polymer to perform coordination complexation, and then a mixed solution is obtained; then, zinc oxide, BYK-333, Optifilm-400 and fumed silica are sequentially added to the mixed solution to obtain a multi-component mixed solution; after the multi-component mixed solution is dispersed, vacuum concentration is performed to obtain a self-repairing ship antifouling coating with a solid content of 45±5 wt%. The coating prepared by the method has good self-repairing and antifouling properties.

A method for measuring the concentration of ortho-phthalaldehyde (OPA) in a sample is provided. The method involves the use of a spectrophotometer to measure the absorbance of OPA at a specific wavelength, and the use of a standard curve to convert the change in absorbance value with temperature (slope) to a concentration value. The method is specific (selective), simple, rapid, and highly accurate, making it suitable for use in a variety of applications, such as the monitoring of OPA concentrations in disinfection / sterilization industrial settings.

The invention relates to an o-phthalaldehyde disinfectant. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.1-1 wt% of o-phthalaldehyde; 10 to 30 weight percent of polybasic acid salt; 0.01 to 0.05 wt% of an antioxidant; 0.005 to 0.05 wt% of a polymerization inhibitor; 0.1 to 0.5 wt% of a slow release agent; and the balance of water. The o-phthalaldehyde disinfectant disclosed by the invention can effectively prevent grey dyeing, is short in sterilization time and is suitable for high-level disinfection and sterilization of medical instruments.

The application discloses a synthesis method of o-phthalaldehyde. O-xylene, a halogenated reagent and an organic solvent are mixed, and under ultraviolet light irradiation, a bromination product with different bromination degrees is generated by reaction; water is added into the reaction liquid, and the reaction is continuously carried out; after the reaction is completed, the organic solvent and water are removed by evaporation, and a crude ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product is obtained; the crude product is recrystallized to obtain ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product; and the ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene is hydrolyzed to obtain o-phthalaldehyde. The synthesis method optimizes the bromination and hydrolysis process, and by adding appropriate water in the o-xylene bromination process, the yield of the final product o-phthalaldehyde is improved.

The application provides a high-dispersibility water-based covalent organic framework soil modifier and application thereof in saline-alkali soil treatment. 2 The porous covalent organic framework material is synthesized from p-phthalaldehyde and sulfonated modified tri(4-aminophenyl)amine monomers; and a surfactant and / or a stabilizer are further added. The porous covalent organic framework material is synthesized from p-phthalaldehyde and sulfonated modified tri(4-aminophenyl)amine monomers, in-situ condensation is performed, and sulfonic acid groups are uniformly introduced, so that the hydrophilicity is improved, good adsorption capacity can be maintained in subsequent drip irrigation, and the nanoscale water dispersion liquid is prepared through subsequent high-pressure homogenization process.

The present invention provides a reprocessable bio-based cross-linked polyamide and a preparation method thereof, belonging to the technical field of high molecular polymers. The present invention can obtain an amino-terminated prepolymer by first prepolymerizing a linear diamine and phthalaldehyde, and then polymerizing it with trimethyl citrate, which is conducive to the full completion of the reaction, so that the imine bond is introduced into the polymer, so that the cross-linked polyamide has reprocessability, self-healing and degradability; the method provided by the present invention is simple to operate, and does not require the addition of organic solvents and highly toxic catalysts, and the process cost is low and more environmentally friendly. The results of the examples show that the polyamide prepared by the present invention has a tensile strength of >18MPa; elongation at break >10%; melting temperature >98.6°C; 20°C < glass transition temperature <60°C; thermal decomposition 5% temperature >260°C; and mechanical property retention rate of repeated processing >85%.

The present invention relates to disinfection technology, and particularly to a quality control technology for o-phthalaldehyde disinfectant solution. A rapid detection indicator card impregnation composition for o-phthalaldehyde disinfectant solution, which comprises the following in mass percentages: stabilizer: 1% - 10%; chelating agent: 5% - 20%; neutralizing agent: 0.1% - 2%; chromogenic agent: 0.1% - 20%; chromogenic accelerator: 1% - 4%; the balance is pure water. After impregnating filter paper with the composition and drying it, it is pasted on white plastic paper with double-sided tape and compacted to form the rapid detection indicator card. The indicator card of the present invention has more stable, obvious and clear color development, rapid detection and more reliable results.

Methods of constructing conjugates are disclosed. The preparation method comprises the following steps: reacting an amino-containing component and a thiol-containing component with o-phthalaldehyde in one step under a considerable molar ratio to generate a conjugate with a substituted or unsubstituted 1-thio-isoindole structure in the presence of an additive. The method provides an efficient and practical platform for constructing the biological activity modular primitive.

The invention relates to a metal organic framework siloxane self-repairing antifouling composite material and a preparation method and application thereof.The preparation method comprises the steps that multiple kinds of siloxane containing amino are mixed to obtain mixed amino silane, terephthalaldehyde, absolute ethyl alcohol and diluted hydrochloric acid are added into the mixed amino silane, and heating is conducted to obtain a siloxane prepolymer solution; dropwise adding a silver nitrate solution into a trimesic acid solution to react to generate a silver ion organic framework material; and finally, adding the silver ion organic framework material into the siloxane prepolymer solution, uniformly dispersing, heating and curing to obtain the metal organic framework siloxane self-repairing antifouling composite material. The material has excellent self-repairing capability, when the material is broken, the self-healing of a damaged area can be realized under a mild condition, and the original mechanical property and barrier function of the material can be recovered; the introduction of the silver ion organic framework material not only plays a reinforcing role, but also endows the composite material with potential antibacterial performance, and widens the application prospect of the composite material in the antifouling field.

The invention discloses a lithium ion battery diaphragm, a preparation method and a battery thereof, the lithium ion battery diaphragm comprises a base membrane and a coating layer coated on the single side surface of the base membrane, the coating layer comprises the following raw materials by mass: 0.6%-2% of polymer particles, 38%-39.4% of a binder, 42%-54% of a solvent, and 6%-18% of a dispersant; the polymer particles are prepared by polymerizing 2, 4-diamino-6-chloropyrimidine or 2, 4-diamino-6-fluoropyrimidine and terephthalaldehyde, so that collaborative optimization of thermal stability and wettability of the diaphragm is realized, and meanwhile, the cycling stability and rate discharge performance of a battery are improved.

The invention discloses a gel polymer electrolyte membrane for a lithium battery as well as a preparation method and application thereof, and belongs to the field of polymer electrolyte. The preparation method provided by the invention comprises the following steps: putting amino-terminated polyethylene glycol and phthalic dicarboxaldehyde into inert gas to react to obtain a first prepolymer; adding tetraethylene glycol dimethacrylate and a photoinitiator into the first prepolymer, reacting to obtain a second prepolymer, adding lithium salt into the second prepolymer, and uniformly mixing to obtain precursor slurry; and carrying out film coating treatment on the precursor slurry, and sequentially carrying out ultraviolet curing treatment and standing treatment after film coating to obtain the gel polymer electrolyte membrane. According to the invention, a dynamic imine bond network is constructed through o-phthalaldehyde and double-end amino polyethylene glycol, a three-dimensional ion transmission channel is constructed by using an ether oxygen branch chain of tetraethylene glycol dimethacrylate, and self-repairing is realized by combining spontaneous reversible recombination of an imine bond under environmental humidity; and the high ionic conductivity of the polymer film is ensured to meet the high-frequency charging and discharging requirements.

The invention discloses a post-column derivatization detection method of ethyl lauroyl arginate, which comprises the following steps: pre-treating food, extracting ethyl lauroyl arginate hydrochloride with an acetonitrile aqueous solution, filtering with an aqueous filter membrane, separating with a high performance liquid chromatography column, taking mercaptan and o-phthalaldehyde as derivatization reagents, and carrying out post-column derivatization detection on ethyl lauroyl arginate under an alkaline condition, so as to obtain the ethyl lauroyl arginate. And carrying out a derivative reaction to generate a fluorescent derivative, carrying out derivative fluorescence detection, and quantitatively determining the content of the ethyl lauroyl arginate hydrochloride. The method has the characteristics of rapidness, high sensitivity and low detection limit. The method is suitable for determination of trace ethyl lauroyl arginate hydrochloride in dairy products, fruit products, meat products, aquatic products, beverages or gum-based candies. And a detection method is provided for the detection of trace ethyl cinnamyl arginate hydrochloride.

The application discloses a sub-micron Py-TPA COF monocrystal wafer and a preparation method thereof, and belongs to the material field. The preparation method of the Py-TPA COF monocrystal wafer comprises the following steps: mixing tetra-(4-aminophenyl)pyrene, p-phthalaldehyde, mesitylene and an acetic acid solution, and performing a solvothermal reaction to obtain the Py-TPA COF monocrystal wafer. The preparation method has the advantages of short reaction time and high reaction yield, and the prepared sub-micron Py-TPA COF monocrystal wafer has uniform morphology and size.

The present invention provides an anionic polymer grafted covalent organic framework material and a preparation method and application thereof. The covalent organic framework material COF-V is synthesized by polymerizing 1,3,5-tri(4-aminophenyl)benzene and 2,5-divinyl-1,4-phthalaldehyde, and polymer hair is grafted on the surface of COF-V using 2-acrylamido-2-methyl-1-propanesulfonic acid as a monomer to obtain a novel covalent organic framework molecular brush COF- g ‑PAMPS. COF‑ g On the one hand, ‑PAMPS has the high chemical stability of COF‑V materials and can resist gastric acid, making it suitable as a drug delivery platform for oral drugs; on the other hand, it can carry a negative charge in aqueous solution and has the characteristics of mucosal adhesion and receptor interaction when used as a drug delivery platform, which is conducive to adhering to the positively charged inflamed colon mucosal surface and targeted release of drugs.

The invention discloses a coordination europium ion-based post-modification COF fluorescent composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking terephthalaldehyde and melamine as construction elements, preparing a melamine covalent organic framework with abundant binding sites, embedding Eu < 3 + > ions into the melamine covalent organic framework through heating reflux by adopting a post-modification method, and then adding 2-thiophenoyl trifluoroacetone and a phenanthroline ligand for modification, thereby obtaining the Eu < 3 + > covalent organic framework. According to the present invention, the europium ion coordination-based post-modification COF fluorescent composite material with the antenna effect is constructed, after the fluorescent probe is prepared, the abundant Eu < 3 + > on the melamine-based covalent organic frame skeleton can be coordinated with more target to-be-detected substances TC, and the performance test characterization results show that the fluorescent probe has the characteristic that the fluorescent probe has the characteristic of the europium ion coordination-based post-modification COF fluorescent material; the fluorescent probe disclosed by the invention has high selectivity and high sensitivity on detection of tetracycline antibiotics, the detection limit is 1.36 mu mol / L, and the fluorescence intensity and the tetracycline concentration are in a good linear relationship.

The present invention belongs to the field of macromolecular and polymer synthesis. Aiming at the problems that the polymerization reaction of polyphthalaldehyde (POPD) generated by polycondensation of POPD monomer usually needs to be carried out at an ultra-low temperature (≤-40°C), the polymer has poor stability at room temperature and is easy to depolymerize, and the polymer needs to be end-capped after the reaction, the present invention provides a single-component organic Lewis acid-base pair having the structural formula: #imgabs0#n is the carbon chain length, R is any one of hydrogen, methyl, ethyl, butyl, phenyl or substituted phenyl; X is any one of halogen Cl, Br, I, acetate, trifluoroacetate, and succinate; R 1 、R 2 It is one or a combination of hydrogen, alkyl, cycloalkyl, aryl or substituted aryl; Y is a bridged skeleton. The single-component organic Lewis acid-base pair can achieve polymerization of o-phthalaldehyde and epoxy compounds under relatively mild conditions, and the obtained polymer does not need to be end-capped and can be purified for use.

The present invention relates to a ratio fluorescence paper-based sensor for in-situ visual detection of soil ammonium nitrogen, which is used for on-site real-time monitoring of soil ammonium nitrogen status. In the presence of potassium sulfite, 1,2-phthalaldehyde can be combined with NH4 + A derivatization reaction occurs at room temperature to generate a derivative with blue fluorescence, and a self-reference background fluorescent material (red CdTe quantum dots) is introduced to construct a ratiometric fluorescence paper-based sensor. Ratiometric fluorescence detects NH4 based on the change in fluorescence intensity ratio. + , can eliminate the interference of various environmental factors, and at the same time has a multi-level color change effect to make data interpretation more accurate and more conducive to naked eye visual detection. The present invention can monitor the real-time status of soil ammonium nitrogen as conveniently as the use of pH test paper, for NH4 + The detection provides a very effective and practical technical means, and has good application prospects in the field of rapid detection of ammonium nitrogen in soil.

The present invention relates to polysaccharide-based polymeric crosslinkers, polysaccharide-based biomaterials, preparation methods, and uses. In the present invention, the polysaccharide-based polymeric crosslinker is a polysaccharide-based polymeric crosslinker modified with ortho-phthalaldehyde groups, which does not rely on a synthetic hydrophilic polymer backbone or complex chemical synthesis processes. The polysaccharide-based polymeric crosslinker provided by the present invention, together with water-soluble small molecules or polymers containing one or more groups selected from the group consisting of primary amine, hydrazine, hydrazide, hydroxylamine, and mercapto groups, forms a two-component polysaccharide-based hydrogel material in an aqueous medium. This two-component polysaccharide-based hydrogel material has the advantages of being injectable, having low swelling, and having high tissue adhesion. Furthermore, the two-component polysaccharide-based hydrogel material provided by the present invention can be further fabricated into polysaccharide-based biomaterials in the form of membranes, powders, sponges, and other forms, and can be used as tissue adhesives, sealants, hemostats, tissue engineering materials, and other applications, demonstrating its potential for a wide range of biomedical applications.

The application relates to a water-based zinc ion battery composite negative electrode and a preparation method and application thereof. The preparation method comprises the following steps: (1) adding propionic acid into p-phthalaldehyde, indium acetate and pyrrole in sequence to obtain a first mixed solution; immersing a three-dimensional carbon skeleton into the first mixed solution; adding a second mixed solution into the first mixed solution drop by drop; and performing airtight reflux after dropwise addition is completed, so that POF@CC is obtained; (2) taking POF@CC as a working electrode, taking a saturated mercury electrode as a reference electrode, taking a zinc sheet as a counter electrode, composing a three-electrode deposition system, depositing zinc by using a constant current method, and obtaining a water-based zinc ion battery composite negative electrode. The application eliminates disordered sheet growth on a pure carbon substrate, induces single-fiber coaxial compact stacking of metal zinc according to a low surface energy crystal face, forms a novel three-dimensional electrode structure which is wrapped in multiple layers and is compact and coaxial, and constructs a high-performance water-based energy storage composite negative electrode which is free of dead zinc, corrosion-resistant and retains macroscopic flexibility.

The invention discloses an analysis method for precolumn derivatization of a hydrogenation impurity of a melogabalin besylate intermediate, the melogabalin besylate intermediate is MB-2, and the hydrogenation impurity in the melogabalin besylate intermediate is MB-2A, the analysis method comprises the following steps: (1) using a derivatization reagent to perform precolumn derivatization on the melogabalin besylate intermediate; carrying out derivative reaction on the melogabalin besylate intermediate under the catalysis of alkali to obtain derivative reaction liquid; the derivatization reagent is o-phthalaldehyde, fluorenyl methyl chloroformate or 2, 4-dinitrofluorobenzene; and (2) detecting the derivative reaction liquid by using a high performance liquid chromatography-UV detector to obtain the content of the hydrogenated impurities in the melogabalin besylate intermediate. According to the analysis method, the content of MB-2A in MB-2 can be effectively separated and accurately quantified, the accuracy is high, the detection line is low, and the method is high in durability. # imgabs0 #