44 results about "Phthalaldehyde" patented technology

The invention relates to the technical field of carbon material preparation, in particular to phenolic resin-based porous carbon and a preparation method thereof. The core of the preparation method of the phenolic resin-based porous carbon is that the mass ratio of phenolic aldehyde to phenolic aldehyde is optimized (1: (1-1.2)) to ensure sufficient crosslinking, and an amine catalyst is selected to reduce metal residues; meanwhile, terephthalaldehyde is introduced as a cross-linking accelerant, so that the bridging density and thermal stability of a resin network are effectively enhanced, and structural collapse is inhibited in subsequent carbonization; a sectional type carbonization process is further adopted, and the carbon skeleton is preserved by controlling the heating rate. According to the method, the carbonization yield is finally and successfully improved to 58% or above (improved by 15%-20% compared with that of a traditional method), the ash content is remarkably reduced (smaller than or equal to 0.2%), and an excellent material with a small mesoporous structure (the average pore diameter ranges from 2 nm to 10 nm) and a high specific surface area (larger than or equal to 1500 m < 2 > / g) is obtained.

The invention belongs to the technical field of disinfectants and discloses a high-level disinfectant and a preparation method thereof.The high-level disinfectant is prepared from, by mass, 0.1%-3% of phthalic dicarboxaldehyde, 0.2%-0.8% of chelating agent, 2%-5% of penetrating agent, 0.3%-2% of modified starch, 1%-2% of acrylic polymer, 0.1%-0.3% of single-chain quaternary ammonium salt, 0.1%-0.3% of double-chain quaternary ammonium salt, 0.4%-5% of corrosion inhibitor and the balance purified water. Modified starch and polyacrylic acid are fully dissolved in a high-temperature stage, molecular chains are fully expanded, more active sites are exposed, and then the temperature is gradually reduced, so that the molecular chains are orderly arranged, a compact and uniform network structure is formed, and effective release of bactericidal components is ensured. Meanwhile, the single-chain quaternary ammonium salt and the double-chain quaternary ammonium salt are complementary through membrane destruction and internal destruction respectively and have a synergistic effect with the o-phthalaldehyde, so that the sterilization effect is remarkably improved.

The invention relates to the technical field of o-phthalaldehyde disinfectants, and discloses o-phthalaldehyde disinfectant preparation equipment and a preparation method thereof.The o-phthalaldehyde disinfectant preparation equipment comprises a base, a processing barrel fixedly connected to the top end of the base, a liquid drainage pipe fixedly connected to the bottom end of the processing barrel in a penetrating mode, and a water injection pipe fixedly connected to the side wall of the processing barrel in a penetrating mode. A gear is driven by a toothed plate to intermittently rotate, so that the gear controls a baffle through a special-shaped plate to intermittently seal an atomizing mixing barrel, and a mixed solution in the atomizing mixing barrel intermittently flows into a connecting barrel; the problem that the solution in the atomization mixing cylinder cannot flow completely in the process of flowing into the connecting cylinder at a time is avoided, meanwhile, the content of the mixed solution flowing into the connecting cylinder every time is controlled through the concentration detection controller, and then the concentration of the phthalic dicarboxaldehyde disinfectant can be controlled according to needs; furthermore, the flexibility of preparing the phthalic dicarboxaldehyde disinfectant by the equipment is improved.

The invention belongs to the field of synthesis and preparation of Schiff base single crystals, and particularly relates to a p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal and a preparation method thereof. The p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is a Schiff base formed by condensation of one molecule of p-phthalaldehyde and two molecules of 4-amino-3-methylphenol, and is a completely symmetrical bis-Schiff base, and the molecular structural formula of the p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is C22H20N2O2. The compound has good optical performance, can be used as a reaction intermediate product for synthesis of epoxy resin, and has important significance for research of high-thermal-conductivity epoxy resin; and the new single crystal can show excellent photoelectric properties, thermal stability or magnetism, and promotes the innovation of photoelectric devices or spintronics devices.

This invention relates to a method for preparing a β-cyclodextrin functionalized covalent organic framework composite material. The method involves an aldehyde-imine condensation reaction between the aldehyde groups on 2,3,4-trihydroxybenzaldehyde and p-phthalaldehyde and the amino group on hepta(6-amino-6-deoxy)betacyclodextrin to construct a β-CD-COF layer. This one-step method produces a β-cyclodextrin covalent organic framework composite material that exhibits excellent enrichment capacity for phosphopeptides, facilitating purification and extraction. It also shows promising application prospects in mass spectrometry detection and exosome separation.

The invention discloses an imine type COFs (Covalent Organic Frameworks) material for adsorbing gold as well as a preparation method and application thereof, and belongs to the technical field of precious metal recovery. The preparation method specifically comprises the following steps: (1) mixing terephthalaldehyde and acetic acid, and stirring to obtain a suspension; (2) mixing N1, N1 '-(1, 4-phenylene) bis (N1-(4-aminophenyl) benzene-1, 4-diamine and deionized water, dropwise adding the mixture into the suspension, and stirring the mixture; and (3) after the reaction is finished, collecting the generated precipitate, washing and drying to obtain the product. The Schiff base type COFs material with high thermal stability, high specific surface area and good crystallinity is synthesized by pre-activating an aldehyde monomer and an amine monomer with acetic acid in a room-temperature aqueous solution by utilizing the oxidation resistance characteristic of hydroxyl and the dynamic repairing capacity of an imine bond, and the adsorption material has the advantages of high adsorption capacity, high stability and high accuracy, and can be used for preparing the COFs material with high specific surface area and good crystallinity. And the preparation method is green, simple, convenient, universal and efficient, and realizes accurate adsorption of single metal ions under the coexistence of multiple metal ions.

The application belongs to the technical field of ship coating, and particularly relates to a self-repairing ship antifouling coating and a preparation method thereof. 2+ The preparation steps comprise the following steps: polyether amine and 1-pyrene butyric acid are reacted in an ethanol and water mixed solvent to obtain pyrene-based hyperbranched polyether amine; the pyrene-based hyperbranched polyether amine is reacted with p-phthalaldehyde modified by 2,6-diaminopyridine to form a dynamic polymer; a complex solution of ethylenediaminetetraacetic acid and Mg 2+ is added to the dynamic polymer to perform coordination complexation, and then a mixed solution is obtained; then, zinc oxide, BYK-333, Optifilm-400 and fumed silica are sequentially added to the mixed solution to obtain a multi-component mixed solution; after the multi-component mixed solution is dispersed, vacuum concentration is performed to obtain a self-repairing ship antifouling coating with a solid content of 45±5 wt%. The coating prepared by the method has good self-repairing and antifouling properties.

The invention relates to an o-phthalaldehyde disinfectant. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.1-1 wt% of o-phthalaldehyde; 10 to 30 weight percent of polybasic acid salt; 0.01 to 0.05 wt% of an antioxidant; 0.005 to 0.05 wt% of a polymerization inhibitor; 0.1 to 0.5 wt% of a slow release agent; and the balance of water. The o-phthalaldehyde disinfectant disclosed by the invention can effectively prevent grey dyeing, is short in sterilization time and is suitable for high-level disinfection and sterilization of medical instruments.

The application discloses a synthesis method of o-phthalaldehyde. O-xylene, a halogenated reagent and an organic solvent are mixed, and under ultraviolet light irradiation, a bromination product with different bromination degrees is generated by reaction; water is added into the reaction liquid, and the reaction is continuously carried out; after the reaction is completed, the organic solvent and water are removed by evaporation, and a crude ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product is obtained; the crude product is recrystallized to obtain ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene product; and the ɑ, ɑ, ɑ', ɑ'-tetra-brominated o-xylene is hydrolyzed to obtain o-phthalaldehyde. The synthesis method optimizes the bromination and hydrolysis process, and by adding appropriate water in the o-xylene bromination process, the yield of the final product o-phthalaldehyde is improved.

The application provides a high-dispersibility water-based covalent organic framework soil modifier and application thereof in saline-alkali soil treatment. 2 The porous covalent organic framework material is synthesized from p-phthalaldehyde and sulfonated modified tri(4-aminophenyl)amine monomers; and a surfactant and / or a stabilizer are further added. The porous covalent organic framework material is synthesized from p-phthalaldehyde and sulfonated modified tri(4-aminophenyl)amine monomers, in-situ condensation is performed, and sulfonic acid groups are uniformly introduced, so that the hydrophilicity is improved, good adsorption capacity can be maintained in subsequent drip irrigation, and the nanoscale water dispersion liquid is prepared through subsequent high-pressure homogenization process.

The present invention relates to disinfection technology, and particularly to a quality control technology for o-phthalaldehyde disinfectant solution. A rapid detection indicator card impregnation composition for o-phthalaldehyde disinfectant solution, which comprises the following in mass percentages: stabilizer: 1% - 10%; chelating agent: 5% - 20%; neutralizing agent: 0.1% - 2%; chromogenic agent: 0.1% - 20%; chromogenic accelerator: 1% - 4%; the balance is pure water. After impregnating filter paper with the composition and drying it, it is pasted on white plastic paper with double-sided tape and compacted to form the rapid detection indicator card. The indicator card of the present invention has more stable, obvious and clear color development, rapid detection and more reliable results.

The invention relates to a metal organic framework siloxane self-repairing antifouling composite material and a preparation method and application thereof.The preparation method comprises the steps that multiple kinds of siloxane containing amino are mixed to obtain mixed amino silane, terephthalaldehyde, absolute ethyl alcohol and diluted hydrochloric acid are added into the mixed amino silane, and heating is conducted to obtain a siloxane prepolymer solution; dropwise adding a silver nitrate solution into a trimesic acid solution to react to generate a silver ion organic framework material; and finally, adding the silver ion organic framework material into the siloxane prepolymer solution, uniformly dispersing, heating and curing to obtain the metal organic framework siloxane self-repairing antifouling composite material. The material has excellent self-repairing capability, when the material is broken, the self-healing of a damaged area can be realized under a mild condition, and the original mechanical property and barrier function of the material can be recovered; the introduction of the silver ion organic framework material not only plays a reinforcing role, but also endows the composite material with potential antibacterial performance, and widens the application prospect of the composite material in the antifouling field.

The invention discloses a lithium ion battery diaphragm, a preparation method and a battery thereof, the lithium ion battery diaphragm comprises a base membrane and a coating layer coated on the single side surface of the base membrane, the coating layer comprises the following raw materials by mass: 0.6%-2% of polymer particles, 38%-39.4% of a binder, 42%-54% of a solvent, and 6%-18% of a dispersant; the polymer particles are prepared by polymerizing 2, 4-diamino-6-chloropyrimidine or 2, 4-diamino-6-fluoropyrimidine and terephthalaldehyde, so that collaborative optimization of thermal stability and wettability of the diaphragm is realized, and meanwhile, the cycling stability and rate discharge performance of a battery are improved.

The invention discloses a gel polymer electrolyte membrane for a lithium battery as well as a preparation method and application thereof, and belongs to the field of polymer electrolyte. The preparation method provided by the invention comprises the following steps: putting amino-terminated polyethylene glycol and phthalic dicarboxaldehyde into inert gas to react to obtain a first prepolymer; adding tetraethylene glycol dimethacrylate and a photoinitiator into the first prepolymer, reacting to obtain a second prepolymer, adding lithium salt into the second prepolymer, and uniformly mixing to obtain precursor slurry; and carrying out film coating treatment on the precursor slurry, and sequentially carrying out ultraviolet curing treatment and standing treatment after film coating to obtain the gel polymer electrolyte membrane. According to the invention, a dynamic imine bond network is constructed through o-phthalaldehyde and double-end amino polyethylene glycol, a three-dimensional ion transmission channel is constructed by using an ether oxygen branch chain of tetraethylene glycol dimethacrylate, and self-repairing is realized by combining spontaneous reversible recombination of an imine bond under environmental humidity; and the high ionic conductivity of the polymer film is ensured to meet the high-frequency charging and discharging requirements.

The invention discloses a post-column derivatization detection method of ethyl lauroyl arginate, which comprises the following steps: pre-treating food, extracting ethyl lauroyl arginate hydrochloride with an acetonitrile aqueous solution, filtering with an aqueous filter membrane, separating with a high performance liquid chromatography column, taking mercaptan and o-phthalaldehyde as derivatization reagents, and carrying out post-column derivatization detection on ethyl lauroyl arginate under an alkaline condition, so as to obtain the ethyl lauroyl arginate. And carrying out a derivative reaction to generate a fluorescent derivative, carrying out derivative fluorescence detection, and quantitatively determining the content of the ethyl lauroyl arginate hydrochloride. The method has the characteristics of rapidness, high sensitivity and low detection limit. The method is suitable for determination of trace ethyl lauroyl arginate hydrochloride in dairy products, fruit products, meat products, aquatic products, beverages or gum-based candies. And a detection method is provided for the detection of trace ethyl cinnamyl arginate hydrochloride.

The application discloses a sub-micron Py-TPA COF monocrystal wafer and a preparation method thereof, and belongs to the material field. The preparation method of the Py-TPA COF monocrystal wafer comprises the following steps: mixing tetra-(4-aminophenyl)pyrene, p-phthalaldehyde, mesitylene and an acetic acid solution, and performing a solvothermal reaction to obtain the Py-TPA COF monocrystal wafer. The preparation method has the advantages of short reaction time and high reaction yield, and the prepared sub-micron Py-TPA COF monocrystal wafer has uniform morphology and size.

The invention discloses a coordination europium ion-based post-modification COF fluorescent composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking terephthalaldehyde and melamine as construction elements, preparing a melamine covalent organic framework with abundant binding sites, embedding Eu < 3 + > ions into the melamine covalent organic framework through heating reflux by adopting a post-modification method, and then adding 2-thiophenoyl trifluoroacetone and a phenanthroline ligand for modification, thereby obtaining the Eu < 3 + > covalent organic framework. According to the present invention, the europium ion coordination-based post-modification COF fluorescent composite material with the antenna effect is constructed, after the fluorescent probe is prepared, the abundant Eu < 3 + > on the melamine-based covalent organic frame skeleton can be coordinated with more target to-be-detected substances TC, and the performance test characterization results show that the fluorescent probe has the characteristic that the fluorescent probe has the characteristic of the europium ion coordination-based post-modification COF fluorescent material; the fluorescent probe disclosed by the invention has high selectivity and high sensitivity on detection of tetracycline antibiotics, the detection limit is 1.36 mu mol / L, and the fluorescence intensity and the tetracycline concentration are in a good linear relationship.

The present invention belongs to the field of macromolecular and polymer synthesis. Aiming at the problems that the polymerization reaction of polyphthalaldehyde (POPD) generated by polycondensation of POPD monomer usually needs to be carried out at an ultra-low temperature (≤-40°C), the polymer has poor stability at room temperature and is easy to depolymerize, and the polymer needs to be end-capped after the reaction, the present invention provides a single-component organic Lewis acid-base pair having the structural formula: #imgabs0#n is the carbon chain length, R is any one of hydrogen, methyl, ethyl, butyl, phenyl or substituted phenyl; X is any one of halogen Cl, Br, I, acetate, trifluoroacetate, and succinate; R 1 、R 2 It is one or a combination of hydrogen, alkyl, cycloalkyl, aryl or substituted aryl; Y is a bridged skeleton. The single-component organic Lewis acid-base pair can achieve polymerization of o-phthalaldehyde and epoxy compounds under relatively mild conditions, and the obtained polymer does not need to be end-capped and can be purified for use.

The present invention relates to a ratio fluorescence paper-based sensor for in-situ visual detection of soil ammonium nitrogen, which is used for on-site real-time monitoring of soil ammonium nitrogen status. In the presence of potassium sulfite, 1,2-phthalaldehyde can be combined with NH4 + A derivatization reaction occurs at room temperature to generate a derivative with blue fluorescence, and a self-reference background fluorescent material (red CdTe quantum dots) is introduced to construct a ratiometric fluorescence paper-based sensor. Ratiometric fluorescence detects NH4 based on the change in fluorescence intensity ratio. + , can eliminate the interference of various environmental factors, and at the same time has a multi-level color change effect to make data interpretation more accurate and more conducive to naked eye visual detection. The present invention can monitor the real-time status of soil ammonium nitrogen as conveniently as the use of pH test paper, for NH4 + The detection provides a very effective and practical technical means, and has good application prospects in the field of rapid detection of ammonium nitrogen in soil.

The present invention relates to polysaccharide-based polymeric crosslinkers, polysaccharide-based biomaterials, preparation methods, and uses. In the present invention, the polysaccharide-based polymeric crosslinker is a polysaccharide-based polymeric crosslinker modified with ortho-phthalaldehyde groups, which does not rely on a synthetic hydrophilic polymer backbone or complex chemical synthesis processes. The polysaccharide-based polymeric crosslinker provided by the present invention, together with water-soluble small molecules or polymers containing one or more groups selected from the group consisting of primary amine, hydrazine, hydrazide, hydroxylamine, and mercapto groups, forms a two-component polysaccharide-based hydrogel material in an aqueous medium. This two-component polysaccharide-based hydrogel material has the advantages of being injectable, having low swelling, and having high tissue adhesion. Furthermore, the two-component polysaccharide-based hydrogel material provided by the present invention can be further fabricated into polysaccharide-based biomaterials in the form of membranes, powders, sponges, and other forms, and can be used as tissue adhesives, sealants, hemostats, tissue engineering materials, and other applications, demonstrating its potential for a wide range of biomedical applications.

The application relates to a water-based zinc ion battery composite negative electrode and a preparation method and application thereof. The preparation method comprises the following steps: (1) adding propionic acid into p-phthalaldehyde, indium acetate and pyrrole in sequence to obtain a first mixed solution; immersing a three-dimensional carbon skeleton into the first mixed solution; adding a second mixed solution into the first mixed solution drop by drop; and performing airtight reflux after dropwise addition is completed, so that POF@CC is obtained; (2) taking POF@CC as a working electrode, taking a saturated mercury electrode as a reference electrode, taking a zinc sheet as a counter electrode, composing a three-electrode deposition system, depositing zinc by using a constant current method, and obtaining a water-based zinc ion battery composite negative electrode. The application eliminates disordered sheet growth on a pure carbon substrate, induces single-fiber coaxial compact stacking of metal zinc according to a low surface energy crystal face, forms a novel three-dimensional electrode structure which is wrapped in multiple layers and is compact and coaxial, and constructs a high-performance water-based energy storage composite negative electrode which is free of dead zinc, corrosion-resistant and retains macroscopic flexibility.

The invention belongs to the field of protein hydrogel materials, and particularly relates to elastin-like and a preparation method and application of elastin-like hydrogel. According to the present invention, the two elastin-like proteins A and B having different amino acid sequences are utilized to form the cross-linked network through the isopeptide bond, such that the mechanical strength of the polymer hydrogel composed of the four-arm polyethylene glycol amine, 4-arm PEG-NH2 and the o-phthalaldehyde modified four-arm polyethylene glycol, 4-arm PEG-OPA can be effectively improved, the adhesion can be improved, and the cross-linked network can be used for the preparation of the polymer hydrogel, such that the cross-linked network can be formed through the cross-linked network, such that the cross-linked network can be used for the preparation of the polymer hydrogel, and the use amount of the polymer hydrogel can be reduced. The obtained elastin-like hydrogel has the advantages of strong wet tissue adhesion capacity, good biocompatibility, injectable use and the like, and is beneficial to application in the biomedical fields of hemostasis, tissue repair and the like.

This invention discloses an amino acid assay kit based on the o-phthalaldehyde (OPA) method, its preparation method, and its application. Belonging to the field of amino acid detection and analysis technology, it is used for rapid and accurate quantitative detection of amino acids in samples. The amino acid assay kit can not only measure the total amino acid content but also analyze specific amino acids and dipeptides such as alanine glutamine, meeting diverse analytical needs. This amino acid assay kit is suitable for batch testing and supports high-throughput laboratory applications. By optimizing the reagent formulation and operating procedures, this invention effectively simplifies the detection steps, improves detection sensitivity and specificity, and fills the gap in the market for OPA-based assay kits. This invention can be widely applied in nutrition, medicine, clinical diagnostics, and drug development, providing a convenient and efficient amino acid analysis tool for life science and medical research.

The application discloses a bimetallic catalyst for preparing o-phthalaldehyde by dimethyl phthalate hydrogenation and a preparation method thereof, and belongs to the field of catalyst preparation and application. The Ni-Fe / Al2O3-ZrO2 catalyst loaded with nickel and iron bimetal is prepared by taking alumina and zirconium dioxide as carriers, wherein n(Ni):n(Fe):n(Al):n(Zr) = 0.1:0.05:2:1. The Ni-Fe / Al2O3-ZrO2 catalyst is prepared by first preparing a Ni-Fe / Al2O3-ZrO2 catalyst precursor and then carrying out a reduction reaction in a hydrogen atmosphere. The Ni-Fe / Al2O3-ZrO2 catalyst of the application will not be deactivated due to carbon deposition and metal sintering in the high-temperature hydrogenation process, prolongs the service life of the catalyst, promotes the reaction of preparing o-phthalaldehyde by dimethyl phthalate hydrogenation, and has great competitive advantages.

The invention discloses a conjugated microporous polymer based on terephthalaldehyde, a preparation method and application, relates to the related technical field of seawater desalination materials and sewage purification materials, and aims to overcome the technical problem of low photothermal conversion efficiency in the prior art. According to the invention, an efficient, stable and low-cost solution can be provided for seawater desalination and sewage purification.

The invention discloses a method for detecting an impurity E in a granisetron hydrochloride injection by utilizing an HPLC (High Performance Liquid Chromatography) on-line derivatization method, belonging to the technical field of chemical engineering and pharmacy. According to the method, a high performance liquid chromatography method is adopted, an Ultimate AQ-C18 column is used as a chromatographic column, a mixed solution of a 0.1% phosphoric acid solution and acetonitrile is used as a mobile phase, and an o-phthalaldehyde solution is used as a derivatization reagent; quantitative detection of the impurity E in the granisetron hydrochloride injection is realized through specific instrument conditions, solution preparation and measurement recording steps. The method is simple and convenient to operate, strong in specificity, high in sensitivity and accuracy, good in linearity and capable of effectively detecting the quality of the granisetron hydrochloride injection product.

The invention discloses a qualitative evaluation method for the grey dyeing degree of an o-phthalaldehyde disinfectant. The qualitative evaluation method comprises the following steps: S1, observing with naked eyes; s2, carrying out spectral reflection; s3, measuring by a colorimeter; s4, performing macro observation; s5, cleaning and testing; s6, testing the color fastness, namely coating or spraying a solution containing o-phthalaldehyde in a disinfectant on the surface of the sample, generally fibers or other dyeable materials, naturally drying or properly drying the sample, and observing whether the surface has a grey dyeing phenomenon (namely irregular dyeing, dim color or spots) or not. If the surface of a sample becomes non-uniform or obvious grey dyeing spots appear, the grey dyeing degree of the disinfectant is high, the grey dyeing on the cloth is detected, observed and cleaned by various evaluation methods, various equipment and various common methods, various results are combined and analyzed, and the grey dyeing degree of the disinfectant is high. The qualitative evaluation on the grey dyeing degree of the o-phthalaldehyde disinfectant is realized.

The application discloses a method for preparing o-phthalaldehyde from o-xylene. V2O5-TiO2 doped with metal elements is used as a catalyst, o-xylene and an oxygen-containing gas are reacted to obtain a mixed oxidation product containing o-phthalic anhydride, o-phthalic acid and phthalide; the mixed oxidation product is reacted with a reducing agent in a solvent, and o-phthalalcohol is obtained after separation; and the o-phthalalcohol is reacted with an oxidizing agent, and o-phthalaldehyde is obtained after separation. The application avoids the use of corrosive substances such as bromine or chlorine and nitric acid, has low requirements on equipment, is small in environmental pollution, and is high in overall yield of o-phthalaldehyde.

The invention belongs to the technical field of medical carriers, and relates to a hardness-controllable polyethylene glycol nano-drug carrier as well as a preparation method and application thereof. Adsorbing a layer of polyethyleneimine on the surface of the template to obtain a carrier precursor; performing at least one layer assembly on the surface of the carrier precursor; and finally, removing the template. The primary layer assembly process comprises the following steps: firstly, adding multi-arm polyethylene glycol o-phthalaldehyde to carry out a cross-linking reaction, and then adding multi-arm polyethylene glycol amino to carry out a cross-linking reaction; the cross-linking reaction is that the o-phthalaldehyde group reacts with the primary amino group to generate the isoindolinone group. The PEG nano-drug carriers with different hardness can be prepared through a layer-by-layer assembly method, and targeting molecules and / or chemotherapeutic drugs can be introduced in the preparation process; by adjusting the PEG nano-drug carrier with proper hardness and loading the chemotherapeutic drug, the interaction between the nano-drug carrier and a biological interface can be adjusted, so that good tumor treatment is realized.

The present invention relates to a polysaccharide-based polymer cross-linking agent, a polysaccharide-based biomaterial, and a preparation method and application. The polysaccharide-based polymer cross-linking agent in the present invention is a polysaccharide-based polymer cross-linking agent modified with an o-phthalaldehyde group, and the polysaccharide-based polymer cross-linking agent does not rely on an artificially synthesized hydrophilic polymer skeleton and complex chemical synthesis steps. The polysaccharide-based polymer cross-linking agent provided by the present invention and a water-soluble small molecule or polymer containing one or more of primary amine, diamine, hydrazide, hydroxylamine or thiol groups are combined in an aqueous medium to form a polysaccharide-based two-component hydrogel material, which has the advantages of being injectable, low swelling, and having strong tissue adhesion. In addition, the polysaccharide-based two-component hydrogel material provided by the present invention can also be further prepared into polysaccharide-based biomaterials in the form of films, powders, sponges, etc., which can be used as tissue adhesives, sealants, hemostatic agents, tissue engineering materials, etc., and have broad biomedical application prospects.