294 results about "Anti-Microbial Agents" patented technology

A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. An antimicrobial agent can be placed on an interior surface of a retaining ring.

A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. An antimicrobial agent can be placed on an interior surface of a retaining ring.

The present disclosure relates generally to antimicrobial gels. In particular, the present disclosure relates to an antimicrobial gel comprising a eutectic solvent and a gelling agent which can be used as a drug delivery vehicle for antimicrobial agents, including for the topical delivery of antimicrobial agents to the skin of a subject. The present disclosure also relates to processes for preparing the antimicrobial gel, and to methods, uses and compositions comprising the antimicrobial gel.

A comprehensive and sensuous oral cleaner (10A, 10B, 10C, and 10D) is disclosed to automate and modernize all necessary oral hygiene. The cleaner comprises a power driver (12, 12B, 12C, 12D) that can selectively power-drive a replaceable flosser attachment (13, 14, 15, 17), a replaceable synergistic multi-motion toothbrush attachment (29), and an anti-halitosis attachment (81). The driver also power-drives scent from fragrance sources (68, 24) in the attachments for sensuous ambiance while oral cleaning. The toothbrush attachment is detachably connectable to the power driver for imparting plural motions of a long-bristle toothbrush (77). These actions serve for driving long toothbrush bristles to longitudinally penetrate interdentally for power-brushing interdental contours. In the flosser attachment, a floss span is power-driven in plural motions to efficiently remove plaque as the moving span follows, scrubs, and polishes interdental contours between adjacent teeth. Three embodiments of the flosser attachment use warmed power-driven air to dry the used floss for odor-free storage until replacement of the attachment. Alternatively, two of the flosser attachment embodiments feature an antimicrobial (68) that coats the used floss to inhibit microbial activity. The power-driven anti-halitosis attachment drives a multi-bladed tongue scraper (89, 89B) along with pressurized air to neutralize causal anaerobic tongue bacteria.

The present invention relates to a composition comprising an antimicrobial agent (a) as defined in the claims and the description and a specific carboxamide (b) of formula (I), (I), wherein the variables are as defined in the claims and the description; to the use of said carboxamide for enhancing the antimicrobial, in particular the preserving, activity of the antimicrobial agent (a), to a method for enhancing the antimicrobial, in particular the preserving, activity of the antimicrobial agent (a), comprising using the antimicrobial agent (a) in combination with said carboxamide, and to a mixture consisting of at least one antimicrobial agent (a), at least one carboxamide compound of the formula (I) and optionally at least one solvent [different from the carboxamide compounds of the formula (I)].

The present invention primarily relates to a mixture comprising or consisting of one or more compound(s) of formula (I) or (II) as defined herein and one or more further antimicrobial agent(s) and it relates to a product comprising a mixture as defined herein. Moreover, the present invention relates to the use of one or more compound(s) of formula (I) or (II) as defined herein to improve the antimicrobial effect of one or more further antimicrobial agent(s) and to the use of one or more further antimicrobial agent(s) to improve the antimicrobial effect of one or more compound(s) of formula (I) or (II) as defined herein. The present invention further relates to the use of a mixture as defined herein as an antimicrobial agent and to a process as defined herein for improving the antimicrobial effect of one or more compound(s) as defined in step (a) and / or of one or more compound(s) as defined in step (b) of the process. Moreover, the present invention relates to a process for inhibiting or preventing the growth of one or more microorganisms in a product or semi-finished product and to a process for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa and / or for inhibiting or preventing the growth of one or more microorganisms on / in a surface. Moreover, the present invention relates to a mixture or compound as defined herein for use as an antimicrobial agent for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa. Finally, the present invention relates to the use of one or more compound(s) as defined herein as antimicrobial agent(s) and to a process as defined herein for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa, and / or for inhibiting or preventing the growth of one or more microorganisms in a product or semi-finished product, and / or for inhibiting or preventing the growth of one or more microorganisms on / in a surface.

The invention relates to a sterile, ready-to-use, stable aqueous solution of ketamine suitable for direct intravenous infusion to a patient in need thereof, wherein the composition is disposed within a sealed infusion container as a premixture. The invention further relates to aqueous solutions of ketamine that are free of antimicrobials such as benzethonium chloride and are shelf-stable. The pharmaceutical compositions can be used, for example, wherein the subject is in need of anesthesia for a diagnostic or a surgical procedure.

The invention belongs to the technical field of rubber sealing rings, and particularly discloses a wading rubber sealing ring and a preparation method thereof, the wading rubber sealing ring comprises the following components by weight: 60-70 parts of modified ethylene propylene diene monomer, 35-50 parts of modified white carbon black, 20-30 parts of hydrogenated nitrile rubber, 0-10 parts of fluororubber, 2-5 parts of polyester fiber, 0.5-3 parts of an anti-hydrolysis agent, and 1-3 parts of a hydrophobic agent. 2-4 parts of an antimicrobial agent, 3-5 parts of an anti-aging agent and 1-7 parts of sulfur; the anti-hydrolysis agent is a mixture of tetrakis [beta-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid] pentaerythritol ester and a carbodiimide anti-hydrolysis agent; the hydrophobic agent is a mixture of polydimethylsiloxane and perfluorooctyltriethoxysilane, and the hydrophobic agent is a mixture of polydimethylsiloxane and perfluorooctyltriethoxysilane. The wading rubber sealing rubber ring and the preparation method thereof are suitable for fresh water and warm water scenes, and have wide application prospects in ship sealing and sewage treatment equipment in seawater and industrial wastewater scenes.

The invention relates to a compound of formula Ia and / or formula Ib: or a pharmaceutically acceptable salt, solvate or prodrug thereof, where the groups are defined herein. The invention also relates to a pharmaceutical formulation comprising the compound for treating or detecting a microbial infection in a subject, a method of determining antimicrobial resistance of a microbial infection using the compound, and a method of determining an effective dose of one or more antimicrobial agents to kill a microorganism using the compound.

The present disclosure relates generally to conjugated plasmids comprising a multiple entry exclusion system derived from a plasmid carrying a gene conferring undesired traits of interest, such as pathogenic traits, such as antimicrobial drug resistance (AMR), virulence determinants, metal resistance, or other undesired traits, such as, for example, multiple entry exclusion systems derived from plasmids carrying a gene conferring undesired traits of interest. And the use of those probiotic plasmids for protecting bacterial populations (e.g., present in the gut, present in the environment, etc.) from obtaining plasmids imparting the undesirable traits and thereby preventing the propagation of the undesirable traits (e.g., AMR, virulence, metal resistance, etc.) within microbiota.

Provided are an antimicrobial peptide or a pharmaceutical composition thereof, and the use thereof. The antimicrobial peptide is a new efficient antimicrobial peptide, has the characteristics of small molecular weight, broad antibacterial spectrum, high efficiency, no cytotoxicity, no hemolytic property, high stability, low susceptibility to developing drug resistance, etc., and can kill microorganisms including clinically common drug-resistant strains, bacteria, and fungi. Moreover, the antimicrobial peptide has the advantages of simple structure, easy large-scale synthesis and low cost, and the antimicrobial peptide is expected to replace antibiotics to become a safe, green and efficient ideal antimicrobial agent, and has very wide application prospects in the fields of the preparation of antimicrobial drugs, antimicrobial preparations, antimicrobial products, etc.

Suggested is a synergistic antimicrobial mixture comprising a hydroxyacetophenone and one additional antimicrobial agent. The mixture is particular useful for fighting Aspergillus brasiliensis.

The present invention relates to an antimicrobial and healing formulation for skin, designed to effectively target and treat skin conditions such as acne caused by Cutibacterium acnes, cold sore lesions due to the herpes simplex virus, and superficial wounds. This unique formulation combines antimicrobial agents, plant extracts and essential oils in specific proportions in order to exert a synergistic action, enhancing their individual efficacy in the treatment of skin conditions and promoting skin healing. The innovative formulation composed of niaouli (Melaleuca viridiflora) essential oil and tea tree (Melaleuca alternifolia) essential oil, chlorhexidine digluconate, Hamamelis virginiana extract, panthenol, glycerol, and propylene glycol. Each ingredient has been selected for its proven pharmacological properties and its synergistic potential. The formulation works in concert to reduce microbial load, alleviate inflammation, and accelerate skin healing, while providing a gentle and effective application.

The present invention discloses an intelligent, bioengineered wound dressing device that utilizes honey bee-derived therapeutic compounds integrated into a programmable, multi-layered delivery structure designed for sustained antimicrobial release and dynamic wound healing modulation. The device features microencapsulated honey, propolis, and beeswax components embedded within a biocompatible hydrogel matrix, supported by a control technique that processes real-time wound data acquired through embedded biosensors. The technique classifies healing phases, detects wound anomalies, and modulates therapeutic release through actuators based on environmental cues such as pH, temperature, and exudate levels. The system further includes a logic control unit capable of adaptive learning, remote data transmission, and wound trajectory logging, ensuring precise, patient-specific therapeutic delivery. By integrating natural antimicrobial agents with intelligent sensing and release architectures, the invention provides a responsive, self-optimizing wound care platform that enhances healing outcomes, reduces dressing intervention frequency, and improves clinical oversight through real-time therapeutic intelligence.

Described herein are systems, methods, and devices for antimicrobial sensitivity testing (AST) directly from a blood sample. A system for enriching a sample includes a housing configured to receive a sample container, a sample preparation cartridge, and an AST cartridge for processing and testing a sample using one or more centrifuges, a pipetting system, a controller, an AST subsystem, a magnet station, a microscope, and a heater disposed inside the housing. The system is configured for transferring a sample from a blood sample container into a processing tube in a sample preparation cartridge using a septum and needle based pipetting system. After the sample is transferred, the system performs the steps of separating, enriching and concentrating pathogens in the sample for rapid detection. The system then dispenses an aliquot of the enriched sample into reaction wells containing the antimicrobial agent in the AST cartridge, acquires an image of each reaction well after incubation, and determines the sensitivity of the pathogen to the antimicrobial agent based on analyzing the acquired images.

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.

An antimicrobial amphiphilic hydrogel composition for use in haemostasis of a wound comprising: a first cross-linkable amphiphilic component, the first amphiphilic component, in its chemically cross-linked state, being a lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains, the hydrogel comprising an antimicrobial agent covalently attached to the hydrophilic and / or hydrophobic domains.

Provided are methods and systems for injecting desired fluids, especially antimicrobial agents, into crystalline and / or porous solids, and the resulting injected crystalline and / or porous solids. The solids of the present invention that can be injected with antimicrobial agents include erythritol, flavored salt, flavored sugar, baking soda, calcium carbonate, acetic acid, ascorbic acid and marshmallows.

The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and / or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and / or biofilm-embedded microorganisms on a surface.

The invention relates to an antimicrobial peptide consisting of the amino acid sequence: RX1WILX2WLRTWX3X4 wherein X1, X2, X3 and X4 are independently selected from K and R, and wherein each amino acid is independently in the L or D configuration, or a salt or solvate thereof. The use of said antimicrobial peptide in the treatment of an infection caused by Gram negative bacteria, Gram positive bacteria, fungi, and / or yeasts, as well as the use of said peptide as an antimicrobial agent for the prevention of contamination of an article or a living tissue by and / or for the decontamination of an article or a living tissue from Gram negative bacteria, Gram positive bacteria, fungi, and / or yeasts are further aspects of the invention.

Disclosed herein are embodiments of a combination and / or composition for administration to animals. In some embodiments, the combination and / or composition can be administered to treat and / or prevent a disease in animals. In some embodiments, the combination and / or composition can be administered to promote animal health. In some embodiments, the combination comprises a composition comprising Yucca schidigera, Quillaja saponaria, and combinations thereof and a composition comprising an antimicrobial, an antibiotic, an anticoccidial, a vaccine, or combinations thereof. The combinations or compositions disclosed herein can also improve feed conversion rates in animals.

The present invention relates to the use of a compound X selected from the group consisting of compounds of formula (I), glyceryl ethers, sorbitan esters and isosorbide esters, as an antimicrobial agent against a microorganism causing dental caries, a microorganism causing dental plaque or a microorganism causing gingivitis, wherein R is selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

A composition comprising a triazine quaternary ammonium salt and a silane compound, a method for preparing the same, and a method for using the same for applying the composition to surfaces or materials of different chemical natures to impart antimicrobial and antifouling properties to the surfaces or materials. The material obtained by the treatment does not release the antimicrobial agent or antifouling agent into the environment in contact with it and from the treated surface or material.

A surgical incision cover cloth (10) includes a flexible substantially flat area substrate (20) having an upper side (22) and an opposing tissue-facing side having a longitudinal axis (21) and a pressure-sensitive adhesive (40) disposed on the tissue-facing side; at least one hollow microtubular compartment (30) containing a flowable agent (100), the hollow microtubular compartment (30) being positioned to intersect the longitudinal axis (21) and embedded in or positioned on the substrate (20).

Disclosed herein are compositions for topical treatment that can include a therapeutic agent (preferably a topical antimicrobial or antifungal agent such as efinaconazole, tavaborole, or ciclopirox), a non-volatile organic solvent (preferably natural or synthetic vitamin E or vitamin E acetate), and optionally an emollient (such as cholesterol). Also disclosed herein are methods of treating diseases or disorders (preferably as a disease or disorder of the nail, nail bed, or skin, such as onychomychosis) by topically administering compositions that can include a therapeutic agent, a non-volatile organic solvent, and optionally an emollient.

A stapled antimicrobial peptide having the amino acid sequence FFRKSKEK-S5-GKE-S5-KRIV (SEQ ID NO: 1) and its use as an antimicrobial and anticancer agent are provided.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The present invention is directed to a surfactant preparation and end use product comprising alcohol alkoxy sulfates where the preparation and composition display mitigation in dioxane formation when antimicrobial agent is present in the surfactant preparation and end use product.

The present disclosure provides compounds of Formula (I) or (II). The provided compounds may be useful as anti-microbial agents (e.g. antiplasmodial agents). The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating or preventing a disease).

Blood and lung infection is a worldwide health problem, and about five millions of cases of death each year. Early treatments can help rescue life but require better tests to identify these infections. The invention recognizes pathogens, in particular those having antibiotic resistance, more quickly. The invention allows appropriate antibiotic treatment to be performed at an earlier point in time. Data from deep RNA sequencing of human blood is used to create a faster diagnostic test against infection and related antimicrobial resistance.