The invention discloses an anti-stress health compound feed for jewfish. The feed consists of an animal protein source, a plant protein source, a fat source raw material, a sugar source raw material, composite vitamin, composite mineral salt, hepatinica, a Chinese herbal medicine compound preparation, probiotic powder, a composite immunopotentiator, antimicrobial peptide, an acidifying agent and a premixed compound additive, wherein the animal protein source comprises one or more of fish meal, euphausiid meal and chicken meat meal; the plant protein source comprises one or more of seaweed meal, fermented soybean meal, soy protein concentrate and corn protein powder; the fat source comprises one or more of soybean oil, fish oil and phosphatide oil. The feed disclosed by the invention has the characteristics of being rapid in growth, low in food coefficient, good in stability in water, rapid to eat, convenient to use, low in feeding cost, resistant to stress, healthy and the like.