Antibacterial peptide as well as preparation method and application thereof
The antimicrobial peptides are prepared by solid-phase synthesis and coupled with non-steroidal anti-inflammatory drugs, which solves the problem of insufficient activity of existing antimicrobial peptides against drug-resistant bacteria, achieves efficient antibacterial and anti-inflammatory effects, and is suitable for the preparation of antimicrobial drugs and disinfectants.
Patent Information
- Application Number
- CN202510845333.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-23
- Publication Date
- 2025-10-10
AI Technical Summary
Existing antimicrobial peptides have low bactericidal activity against drug-resistant bacteria, and the synthesis process is cumbersome and costly, making it difficult to effectively respond to infections caused by drug-resistant pathogens.
An antimicrobial peptide and its conjugate were designed. The antimicrobial peptide was prepared by solid-phase synthesis and conjugated with non-steroidal anti-inflammatory drugs to enhance the killing ability against drug-resistant bacteria and prepare antimicrobial or anti-inflammatory products.
The prepared antimicrobial peptide has strong antibacterial ability against methicillin-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli, and is not easy to develop drug resistance. The conjugate significantly enhances the antibacterial effect and also has anti-inflammatory efficacy.