183 results about "Large intestine" patented technology

The invention discloses a method for simulating small intestine-colon dynamic digestion and glycolysis of polysaccharide-based food, and belongs to the technical field of food detection. The small intestine-colon simulated digestion and absorption system special for the polysaccharide-based food comprises a small intestine digestion simulation system, a sampling and emptying system, a large intestine glycolysis simulation system and a central intelligent control and display system (a pH control system, a temperature control system, a stirring rate control system, a gas path system and a flow rate control system). Aiming at the limitations that an existing human gastrointestinal tract digestion in-vitro simulation system cannot be continuous, is short in period and the like, the in-vivo real digestion and glycolysis physiological environment and process are simulated, intestinal peristalsis waves and digestion and glycolysis of polysaccharide-based food are simulated, automatic sampling can be achieved, generation of glucose in small intestines can be detected on line, and the in-vitro simulation system fits the real human physiological environment.

The invention relates to the technical field of genetic engineering, and discloses a genetically engineered bacterium for producing L-arginine as well as a construction method and application of the genetically engineered bacterium. Escherichia coli is taken as a starting strain, and the following treatment is performed: overexpressing genes gdhA and gdh of glutamate dehydrogenase, promoting generation of glutamic acid, overexpressing and coding arginine transporter gene argO to enhance extracellular transport of arginine, introducing exogenous argJ to replace a linear synthesis pathway in large intestines, improving the utilization rate of acetyl coenzyme A and accelerating the synthesis efficiency of arginine; a glutamine synthetase gene glnA is over-expressed, and glutamine synthesis is enhanced; the pckA is overexpressed to promote ATP synthesis; meanwhile, speA and adiA genes for coding the arginine decarboxylase are deleted, so that further synthesis of putrescine from L-arginine is inhibited, and the L-arginine accumulation capability of the strain is improved. Through the combined action of the treatment, a genetically engineered bacterium with extremely high L-arginine production yield is finally obtained, and the shake flask fermentation yield can reach 13.7 g / L.

A lumen organ model and an endoscope training system are provided. A luminal organ model (3) is provided with: a model body (11) comprising a hollow lumen body having a lumen surface that simulates at least the lumen of a luminal organ such as the stomach, the large intestine, the bladder, the paranasal sinus, or the uterus; a light source device (13) that emits light in a light-emitting region disposed at at least one predetermined observation site corresponding to a training purpose on the lumen surface of a model body (11) comprising a lumen; and a processor (27) that selectively switches light-emitting regions that emit light by controlling the light source device (13).

The invention discloses a method and equipment for segmenting large intestine effusion and a storage medium. The method comprises the following steps: extracting a target skeleton with the maximum skeleton volume from a three-dimensional intestinal image, and taking the target skeleton as an initial segmentation region; based on the initial segmentation region, performing contour extraction by using an active contour model to obtain an intestine segmentation result; calculating a minimum surrounding circle of the intestine segmentation result in the cross section area; fitting the probability distribution of the large intestine region and the probability distribution of the large intestine effusion region in the minimum surrounding circle by using a Gaussian mixture model; and inputting the fitting result into a graph cut algorithm model to carry out effusion segmentation so as to segment a large intestine effusion region from the large intestine region. By means of the scheme, the large intestine effusion area can be accurately extracted, and the complete large intestine area can be segmented by combining the large intestine effusion area with the large intestine area subsequently.

The invention discloses a traditional Chinese medicine composition for treating chronic constipation and a preparation method thereof.The traditional Chinese medicine composition is prepared from eucommia ulmoides, radix clematidis, aster, rhizoma atractylodis macrocephalae, mangnolia officinalis, poria cocos, codonopsis pilosula, immature bitter orange, cynomorium songaricum, cistanche deserticola, semen cassiae and glycyrrhiza uralensis. The traditional Chinese medicine composition has the functions of warming and tonifying liver and kidney, tonifying kidney and strengthening essence, diffusing and lowering lung qi, invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis and the like, so that body fluid is generated, intestines are moistened and nourished, qi movement is smooth, large intestine conduction is recovered, and constipation, especially chronic constipation of old people or people with deficiency of qi and blood, is effectively treated.

The invention provides a preparation method, application and the like of large intestine expression recombinant A-type botulinum toxin (BONT / A). The recombinant BONT / A nucleic acid expression cassette comprises a tag, a restriction enzyme cutting site and a BONT / A nucleic acid sequence, and an exogenous protease recognition site is not introduced between a BONT / A light chain and a BONT / A heavy chain. The invention also provides a recombinant vector containing the nucleic acid expression cassette, a recombinant bacterium, a coded and expressed protein and the like, the prepared recombinant BONT / A does not introduce exogenous amino acid or only introduces two amino acids at one position, and the consistency of the recombinant BONT / A with the natural A-type botulinum toxin is ensured to the greatest extent. Through novel molecular design and preparation process, the recombinant reBONT / A with higher toxicity and low immunogenicity is efficiently obtained, and wide industrial application is facilitated.

The invention belongs to the field of biological medicines, particularly relates to an oral polypeptide composition system capable of being stably absorbed in gastrointestinal tracts, and particularly discloses an oral polypeptide composition which comprises polypeptide molecules (A), a surfactant (B) and an amino acid single-molecule or double-molecule combination (C), the molecular weight of the peptide medicine used as the medicine in the oral polypeptide composition is in the range of 0.1 kDa to 20 kDa. The acting part of the composition system is small intestine or large intestine; the stability and absorbability of the polypeptide composition in gastrointestinal tracts are obviously improved and enhanced.

The utility model relates to the technical field of food processing equipment, in particular to large intestine roller cleaning equipment which comprises an automatic feeding conveying belt, a roller, a support, a motor and a shell, the automatic feeding conveying belt is arranged on one side of the support, one end of the automatic feeding conveying belt is fixed to the shell, and the automatic feeding conveying belt is used for conveying large intestines to be cleaned into the roller; the roller is rotationally arranged on the support, and a driven gear is arranged on the roller and used for cleaning the large intestine to be cleaned through rotation; the motor is arranged at the bottom of the support and provided with a driving chain wheel which is in transmission connection with the driven gear and used for driving the roller to rotate. The shell is arranged outside the roller, fixed to the support and used for blocking water thrown out in the rotating process. Therefore, the problems that existing large intestine cecum ends and part of colons are abnormal in color and difficult to clean manually are solved.

The invention discloses a digestible quality analysis system for chicken feed, relates to the technical field of chicken feed analysis, and aims to solve the problem of poor simulation effect of digestion of the chicken feed. According to the method, low-temperature and high-temperature staged drying treatment is adopted, the characteristics of components such as moisture and fat in the residues are fully considered, the secretion rules of different alimentary canal parts of animals are simulated, sufficient and reasonable contact of digestive juice and feed is ensured, the simulation process is closer to the real physiological condition, and the situation that the digestion analysis result is affected by liquid amount errors is avoided; animal digestive tracts are scientifically segmented into stomach, small intestine and large intestine stages, corresponding external buffer solution and internal digestive juice are injected respectively, and a real digestion scene is comprehensively simulated from a physical structure to a chemical environment.

The present invention relates to vitamins for use in improving gut health in animals and humans. In particular, it was found that, upon delivery to the large intestine, vitamin B2, vitamin C, and vitamin D can be used for increasing the abundance of the beneficial bacteria Bifidobacterium animalis ssp. lactis in the intestinal tract.

The present invention relates to a pharmaceutical composition for preventing or treating depression comprising a Lactobacillus buchneri 200793 strain, and specifically, to a composition for preventing, improving, or treating depression comprising the strain or a culture of the strain, a food composition for alleviating tension, and an animal feed additive composition for preventing or improving depression. When the composition according to the present invention is administered to a subject, sucrose preference is increased, and the expression level of TPH-1 or SERT in small intestine and large intestine tissue is increased, thereby being highly effective in alleviating depression, and thus the composition can be effectively employed for alleviating and improving various symptoms of depression.

The invention provides a spicy crispy sausage middle sausage. The spicy crispy sausage middle sausage comprises the following raw materials: 30-50 parts of pig intestines, 50-70 parts of pig small intestines, 1.5 parts of white granulated sugar, 1-1.8 parts of table salt, 0.8-1.5 parts of monosodium glutamate, 1.2-2.0 parts of light soy sauce, 0.3-0.8 part of dark soy sauce, 1.6-2.4 parts of oyster sauce, 1.5-3.5 parts of spicy seasoning, 0.25-0.75 part of yeast extract, 0.6-1.5 parts of yellow wine, 0.02-0.08 part of white pepper powder, 0.3-0.9 part of red pepper, 0.5-1.5 parts of green onion sections, 0.5-1.5 parts of ginger slices, 10-30 parts of bone soup, 0.3-0.9 part of compound spices and 55-65 parts of water. According to the present invention, the raw materials are synergistically matched so as to effectively remove the dirty odor of the pig large intestine and the pig small intestine, and the product has characteristics of ruddy and attractive appearance and elastic and crisp taste so as to improve the quality of the product.

The invention discloses a preparation method and application of fucose and an intermediate thereof. The method for synthesizing the GDP-fucose comprises the following steps: taking guanosine diphosphate and cane sugar as substrates, and carrying out catalytic reaction on cane sugar synthase, CDP-tetrose 2-epimerase, GDP-mannose dehydratase and isoreductase to generate the GDP-fucose. The method for synthesizing the fucosyllactose comprises the following steps: taking GDP-fucose and pNP-lactose as initial substrates, and obtaining the fucosyllactose under the catalytic action of Hp13FucT2 enzyme. According to the method for preparing the L-fucose through the enzyme method, fucosyllactose is used as a substrate, and the L-fucose is generated through a fucosidase catalytic reaction. The adopted large intestine expression system has the characteristics of high expression efficiency, large expression quantity, low cost, easiness in operation and the like, and the expressed fucosidase has the advantages of high purity, high yield and the like.

A bioflexible elastomer intestinal anastomosis stent based on a PTMC-b-PEG-b-PTMC copolymer, and a preparation method. Biocompatible degradable polymer medical materials, i.e., PTMC and PEG, are selected, an electrostatic spinning method is used for preparation, the size of an anastomosis tube can be adjusted according to the size of a human lumen, and the anastomosis tube is designed to not only be suitable for an anastomat of the small intestines and large intestines, but also suitable for an anastomotic and pre-supported lumen anastomat of an esophagus, artery, vein, etc. The anastomosis tube prepared has a thin wall and excellent elasticity, and in order to facilitate suturing by a doctor during a clinical surgical operation, the anastomosis tube is innovatively and seamlessly sleeved outside a plant cellulose tube having high hardness.

The utility model provides a disposable haemorrhoids treatment suppository, which comprises a treatment suppository body, the treatment suppository body comprises a suppository head, corrugated bulges, a cap, a capacity bin, a suppository tail, external threads and helical teeth, the surface of the suppository head is provided with a plurality of corrugated bulges, and a space is arranged between every two adjacent corrugated bulges. A bolt tail is integrally formed at the top of the bolt head, an opening is formed in the end of the bolt tail, a cover cap is arranged on the surface of the bolt tail in a sleeving mode, and oblique teeth are integrally formed on the side edge of the bolt tail. According to the haemorrhoids treatment suppository, the sealing effect on the suppository tail part is achieved through the additionally arranged cap structure, the cap can only be tightened but cannot be unscrewed, it is ensured that the problem of loosening after sealing is completed cannot occur, and the probability of liquid leakage is reduced. A plurality of corrugated bulge structures are additionally arranged on the suppository head part, and the contact surface with the large intestine can be effectively increased through the corrugated bulges, so that the overall treatment effect is better.

An ingestible in-vivo gastrointestinal device constituted of: a power source; a processor and a memory; and a sensor, the processor, at least partially responsive to the sensor, to determine a location of the in-vivo gastrointestinal device as being in one of an esophagus, a stomach, a small intestine and a large intestine of a subject.

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

The present application relates to an oral polypeptide composition system stably absorbed in the gastrointestinal tract, and specifically discloses an oral polypeptide composition. The composition comprises a polypeptide molecule (A), a surfactant (B), an amino acid monomolecular or a bimolecular combination (C). The molecular weight of a peptide drug used as a drug in the oral polypeptide composition is within a range of 0.1 kDa to 20 kDa. The action part of the composition system is small intestine or large intestine; and the polypeptide composition has obviously improved and increased stability and absorbability in the gastrointestinal tract.

1. The name of this design product: Food packaging bag (clear water large intestine). 2. Purpose of this design product: used as food packaging bag. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view. 5. This design is a thin product, and the left view, right view, top view, bottom view, and stereoscopic view are omitted. 6. Other situations that require explanation Other explanations: The gray area marked "B" in the rear view is made of transparent material.

According to the application plaster formula for treating abdominal distension and constipation and the application method thereof, the effective components of the medicine are absorbed by stimulating acupuncture points, so that the effect of preventing and treating abdominal distension and constipation is achieved. The traditional Chinese medicines are ground into powder, the powder is blended into paste with normal saline, the paste is applied to an adhesive plaster, and the paste is applied to the acupoints of the abdomen (Shenque and Tianshu), the back (large intestine shu and small intestine shu) and the legs (Zusanli and upper giant deficiency), the Tianshu is the acupoint of the large intestine in the abdomen, the large intestine shu and the small intestine shu are the large intestine, and the back shu-acupoint of the small intestine in the back. Zusanli and upper giant deficiency are stomach meridian and large intestine meridian at the lower he acupoints of the legs. The compatibility of the acupuncture points embodies the compatibility use of the Yu-Mu matched acupuncture point and the Xiahe acupuncture point. The effect is better than that of purely applying to the Shenque acupoint. The traditional Chinese medicine composition conforms to the traditional Chinese medicine composition principle and the acupoint compatibility principle, the effect is better than that of single medicine and single acupoint application, and application transdermal absorption is easier to accept by people compared with oral medicine.

The invention relates to the technical field of food formulas and processing, and discloses a formula and making method of flour special for diabetics, and the flour is composed of oat bran, wheat gluten, flaxseed, coconut powder, erythritol, white kidney bean extract, mulberry leaf polypeptide, beta glucan and L arabinose. According to the invention, the content of effective carbohydrates in the flour with the same weight is reduced, the white kidney bean extract, the mulberry leaf polypeptide and the beta glucan effectively inhibit the increase of blood sugar, and the L arabinose can hinder the absorption of glucose in large intestines and discharge redundant glucose through excrement, so that the burden of medication and kidneys is reduced; the product disclosed by the invention is balanced in nutrition and suitable for being eaten by the diabetic for a long time.

The utility model discloses a limit structure of a intestine scraping machine, which relates to the technical field of intestine scraping machine equipment and comprises a base, an extrusion device is arranged at the upper end of the base, limit frames are symmetrically and fixedly mounted at the upper end of the base, limit mechanisms are arranged at the lower ends of the limit frames, and the same linkage mechanism is arranged on the outer sides of the limit mechanisms. By adopting the structure, the two-way screw rod in the limiting frame rotates in the mounting groove, so that the two movable rods in threaded connection with the outer side of the two-way screw rod can slide close to each other or away from each other, and safe limiting adjustment is achieved according to the guide mark frame and the graduated scale in combination with the processing amount of a large intestine; the lower half part of the moving rod is rotationally provided with the rod sleeve through the limiting rod, and the large intestines processed by the extrusion device can be conveniently limited by utilizing the rod sleeve after proper adjustment, so that the conditions of excessive deviation, displacement and the like in the processing process of the large intestines are avoided.

Aspects of the present disclosure relate to compositions and methods for treating one or more inflammatory bowel diseases ("IBD"), such as ulcerative colitis ("UC") and / or Crohn's disease. Some embodiments relate to a pharmaceutical dosage form comprising a core comprising an inhibitor of a protease (e.g., a bacterial protease) and a controlled release coating applied to an outer surface of the core. In some cases, the protease inhibitor is a gligliptin or a pharmaceutically acceptable salt thereof. In some cases, the controlled release coating is configured to release the protease inhibitor in the large intestine (e.g., colon) and / or small intestine of a subject administered the pharmaceutical dosage form. Some embodiments relate to methods of treating one or more IBDs comprising delivering a therapeutically effective amount of an inhibitor of a protease (e.g., bacterial protease) to the large intestine (e.g., colon) and / or the small intestine of a subject.

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel diseases, comprising Lactobacillus murinus as an active ingredient. More specifically, it has been identified that drinking three times a week significantly reduces the length of the large intestine in comparison to other drinking patterns, and it has been identified that by administering Lactobacillus murinus, intestinal inflammation is improved such as with respect to large intestine length restoration and an increase in goblet cell count, and thus the present invention can be variously utilized as a therapeutic agent for inflammatory bowel disease, a health functional food composition and the like.

[Problem] To provide a method or program for obtaining a virtual large intestine cleansing image that can remove residual matter from large intestine imaging data captured without the use of laxatives. [Solution] The method includes: an image input step, in which a captured image representing a part of a patient's large intestine is input; and a virtual large intestine cleansing step, in which a virtual large intestine cleansing image representing a part of the patient's large intestine with residual matter removed from the captured image is obtained. The invention also provides a program for causing a computer to execute the above method for obtaining virtual large intestine cleansing images.

Disclosed are a system and method for analyzing a stool image, which derive the state of the large intestine of a user by analyzing a stool image by using a pre-trained deep learning model. The system for analyzing a stool image may include an input unit configured to receive stool images of a user, a data set generation unit configured to generate a data set by grouping the stool images in chronological order, an analysis unit configured to derive information on a stool state of the user or information on a state of the large intestine of the user by analyzing the data set, and an output unit configured to output the information on the stool state or the information on the state of the large intestine. The endoscopic activity of ulcerative colitis can be predicted from a camera image of stool even without performing a colonoscopy.

1. Name of the designed product: packing box (white water intestine). 2. Use of the designed product: for packing sausage. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The utility model relates to a cloth-saving wave-edge hair band, which comprises a cylindrical cloth strip and rubber bands, the outer side of the cylindrical cloth strip is provided with a concave-convex wave structure, the rubber bands are arranged in the cylindrical cloth strip, the cylindrical cloth strip is connected end to end to form a ring shape, the rubber bands are connected end to end in the cylindrical cloth strip, and the rubber bands are arranged in the cylindrical cloth strip. The edge of the cloth-saving rippled-edge hair band is wavy, the rippled-edge effect generated after the cloth of a traditional large-intestine hair band is shrunk and folded can be simulated, compared with the traditional large-intestine hair band made of cloth with the same length, the waves of the cloth-saving rippled-edge hair band look more and more fluffy, the hair band with more and larger waves can be made of less cloth, and the cloth-saving rippled-edge hair band is more attractive in appearance. Therefore, the cloth is saved, the production cost is reduced, even if the rubber band in the cloth-saving rippled-edge hair band is enlarged, the rippled edge still exists all the time, and the problem that the rippled edge disappears and loses aesthetic feeling when the rubber band in a traditional large intestine hair band is enlarged and wound on hair is solved.

The invention provides a general induction method for original digestive tract partition. The method comprises the following steps: high-quality human pluripotent stem cell verification, pluripotent stem cell sensitivity test, cell inoculation and start convergence degree verification, endoderm-mesoderm co-induction, original digestive tract induction and original digestive tract partition. Compared with a traditional method, on the premise of not depending on serum, original digestive tract partition derivatives (in a 3D sphere form) of different organs such as lungs, stomachs, livers, pancreas, small intestines and large intestines can be efficiently generated, and subsequent batch preparation of final products is facilitated. The method is helpful for promoting large-scale industrial transformation and application of respiratory digestive tract organs.

The present invention relates to the field of biotechnology. Specifically, it relates to a co-fermentation method of Clostridium butyricum and Lactobacillus amylovorans. The co-fermentation method uses a compound preparation, and the compound preparation contains a Lactobacillus amylovorans and Clostridium butyricum. The Lactobacillus amylovorans is Lactobacillus amylovorus, and its strain number is RZ-D4L1, which is preserved in the China Center for Type Culture Collection, and the preservation number is: CCTCC NO: M 2024761; the Clostridium butyricum HZNDC-1 is isolated from the large intestine of cattle, and is preserved in the China Center for Type Culture Collection, and the preservation number is: CCTCC NO: M 2021874. The co-fermentation of the present invention can improve the fermentation stability of Clostridium butyricum, and at the same time, there is also a significant increase in the viable cell count and sporulation rate of Clostridium butyricum, providing a new fermentation method for the high-density fermentation of Clostridium butyricum, which can increase the probiotic performance of the fermentation supernatant, improve the utilization value of the waste liquid of Clostridium butyricum, and has great popularization and application value.