149 results about "Third aortic arch" patented technology

Delivery systems for delivering an aortic repair device to treat a diseased portion of the aorta of a patient at or near the aortic arch and associated devices and methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include an outer catheter, an inner catheter assembly extending at least partially through the outer catheter, a handle, a tip capture mechanism configured to releasably secure an end portion of the aortic repair device, and a release wire actuatable to release the end portion from the tip capture mechanism. The handle can be actuated to retract the outer catheter relative to the inner catheter assembly to deploy the aortic repair device. The handle can also be actuated to advance a portion of the inner catheter assembly relative to the outer catheter to reorient and position the end portion of the aortic repair device.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

The invention discloses a blood flow maintaining device, an aorta covered stent system and a windowing method of an aorta covered stent, the blood flow maintaining device comprises a conveying sheath and a blood flow maintaining net basket, the conveying sheath comprises a sheath tube, and the blood flow maintaining net basket comprises a net basket and a pushing assembly; the net basket has an unfolded state and a folded state; the pushing assembly is connected with the net basket, and the pushing assembly is used for pushing the net basket in the sheathing canal; when the mesh basket is in an unfolded state after being released outwards from the far-end opening of the sheath tube, the mesh basket is suitable for supporting the aorta covered stent and forming a covered stent external blood flow channel on the outer side of the aorta covered stent. When the blood flow maintaining net basket is applied to an aortic arch intracavity isolation treatment operation, the net basket can ensure that the blood flow of each branch is not interrupted before branch windowing is completed, the requirements for hospital conditions and the operation level of an operator are reduced, the operation time is shortened, meanwhile, postoperative complications are reduced, and operation popularization is facilitated.

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

The present invention relates to the technical field of medical devices, and discloses a special covered stent for in situ fenestration of an aortic arch, wherein the proximal end of the aortic covered stent is provided with 2-3 Z-wave stent rings (proximal Z-wave stent ring group) and 1 proximal small-wave stent ring, the distal end is provided with 3-4 Z-wave stent rings (distal Z-wave stent ring group), the middle section of the aortic covered stent is provided with a saddle-shaped metal stent ring, the aortic stent is fully covered with a coating, and the coating has a grid-like reinforcing wire. The special covered stent for in situ fenestration of an aortic arch mainly provides a special covered stent for in situ fenestration for in situ fenestration technology, which improves the success rate of fenestration and reduces the probability of stenosis caused by compression of the branch stent by the angle of the metal ring.

The invention discloses a traditional Chinese medicine composition with an effect of improving artery blood vessel plaque and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The technical problem to be solved is to provide a traditional Chinese medicine composition capable of improving vascular plaques such as carotid artery, aortic arch, brachial trunk, subclavian artery and the like aiming at the current situation that adverse reactions exist when statin lipid-lowering drugs and antiplatelet drugs are taken for a long time to treat artery vascular plaques. According to the technical scheme, the traditional Chinese medicine composition with the effect of improving the artery blood vessel plaque is characterized by comprising radix puerariae, red yeast rice, folium cortex eucommiae, hippophae rhamnoides leaves and natto.

The utility model relates to an intravascular stent, a stent system and a windowing area adjusting method, a stent body section is provided with a stent body inner cavity with two through ends, a branch window penetrating through the stent body inner cavity is formed in the side wall of the stent body section, and the branch window is located on the side wall of the first end of the stent body section and formed to the end side of the first end of the stent body section; the pipe body section is provided with a pipe body inner cavity with two through ends, and one end part of the pipe body section is connected with the second end part of the frame body section, so that the pipe body inner cavity is communicated with the frame body inner cavity. The branch windows of the two intravascular stents can be spliced into a complete closed window, and the overlapped length of the two intravascular stents can be adjusted to adapt to the actual sizes of the three branches on the arch to construct a windowing area with a proper size, so that the blood supply of the three branches on the arch is ensured. When the stent is used for interventional operation, in-vitro windowing or in-situ windowing is not needed, and when the stent is used for open operation, the number of anastomotic stomas can be reduced, the circulation stopping time can be shortened, and meanwhile the three-branch anatomical structure on the arch can be reserved. Therefore, the existing operation requirements are met.

The implant includes an aortic portion and a branch, which is intended to be placed in a first of the three arteries that lead into the aortic arch. The aortic portion and branch are formed by two separate sub-assemblies which are capable of being mounted together; the aortic portion has a first opening capable of receiving the branch and a second opening arranged such that it is located substantially opposite the outlets of the other two arteries when the first opening is located opposite the outlet of the left subclavian artery. The second opening has a specific shape such that the edges of the membrane that define it follow the segments of the underlying annuli, which are in a broken line.

A prosthetic heart valve delivery catheter includes an embolic filter to provide integrated embolic protection to inhibit the release of emboli into the aorta, the aortic arch or branch vessels, and other vasculature during transvascular heart valve replacement procedures. The embolic filter will usually be fixedly or movably attached to a shaft of the delivery catheter proximal of the prosthetic heart valve.

The invention belongs to the technical field of biological medicine, and particularly relates to application of Serpin1 gene as a target spot in preparation of medicine for preventing or treating myocardial fibrosis. In order to screen key molecules for intervening and regulating extracellular matrix balance and provide a basis for developing drugs for preventing or treating myocardial fibrosis, the important function of Serpin1 in myocardial fibrosis is defined through experiments, and the application of Serpin1 gene as a target in preparation of drugs for preventing or treating myocardial fibrosis is provided. Experiments prove that knocking down Serpin1 expression can improve cardiac systolic function damage caused by constriction of the thoracic aortic arch for four weeks, relieve myocardial fibrosis and inhibit activation of myocardial fibroblasts, can be used for preparing the medicine for preventing or treating myocardial fibrosis, and has important practical significance.

Delivery catheter systems and methods for delivery of hypertension treatment implants are provided. Such catheter devices facilitate delivery and placement of an implant in a target region of an aortic arch of the patient to induce baroreflex. Typically, the catheter includes a catheter shaft, and outer sheath constraining an implant with one or more expandable structures in a collapsed configuration, the sheath being retractable to deploy the implant. The catheter can include markers for precise placement and deployment of the implant along the target region. The catheter can include a retention collar that releasably couples with one or more connectors at proximal ends of one or more tethers extending proximally from the implant to allow precise placement at the target region and / or repositioning or removal of the implant. The target region includes a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery.

The present invention provides an individualized thoracic aortic stent system. The individualized thoracic aortic stent system includes an aortic arch stent and an ascending aortic stent. The anchoring area of the aortic arch stent is spliced and implanted into the ascending aortic stent, and the anchoring area of the ascending aortic stent is used as the anchoring area of the system. A first branch hole is pre-opened in the area of the aortic arch stent for connecting a branch stent, and the opening areas of the second branch hole and the third branch hole are locked with the first branch hole as a reference point, and the second branch hole and the third branch hole are opened in the opening areas. A movable, deformable or special-shaped framework structure is arranged in the opening area of the aortic arch stent. Through the splicing between the aortic arch stent and the ascending aortic stent, the anchoring area of the aortic arch stent is arranged in the ascending aortic arch stent, and the anchoring area of the ascending aortic stent is used as the anchoring area of the system, so that the anchoring area is moved forward to avoid the vascular branch fork, enabling the system to adapt to individuals who were previously unsuitable for anchoring.

A branch stent comprises a skirt stent and a tubular stent, and the skirt stent is connected to the proximal end of the tubular stent; the skirt support comprises a skirt supporting framework; the skirt supporting framework comprises a supporting layer and a reinforcing layer which are connected, the supporting layer is connected with the proximal end of the tubular stent and extends outwards from the tube wall of the tubular stent, the end, away from the tubular stent, of the supporting layer is bent inwards to form the reinforcing layer, and the reinforcing layer comprises a plurality of free ends. The skirt support of the branch support is high in stability, and blood leakage at the joint of the branch support and the aortic arch is effectively avoided.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed.

A system for transvascular delivery to an aortic arch of a patient includes an embolic protection device, a connector mechanism, and a catheter or sheath for delivering the embolic protection device to a working zone. The embolic protection device includes a support frame having a distal portion and a proximal portion, and a filter member attached to the support frame and configured for preventing embolic materials from passing there through. At least one of the distal portion and the proximal portion includes a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state. The embolic protection device is pivotable axially but not radially relative to the connector mechanism.

Methods and devices for isolating all of the left subclavian artery, the left common carotid artery, and the brachial artery from embolic debris that may flow through the aortic arch via a single access point are disclosed. The system may include an elongate flexible tubular sheath having a proximal end and a distal end; and an inner member extending through the sheath and movable relative to the sheath. The left subclavian element may be supported by the inner member. The filter membrane may be configured to isolate the aorta from the brachial artery, the left common carotid artery, and the left subclavian artery when the left subclavian element is expanded within the left subclavian artery and the sheath is retracted to expose the membrane. The left subclavian element may include a self-expandable frame that may carry a left subclavian filter.

The invention belongs to the field of medical surgical instruments, and discloses an aortic arch covered stent which comprises a main covered stent body and a main covering film arranged on the stent body. The first puncture part and the second puncture part on the aortic arch section comprise an ascending aorta section, an aortic arch section and a descending aorta section which are connected in sequence, and the aortic arch section is longer than the ascending aorta section and the descending aorta section; the branch covered stent comprises a branch stent body and a branch covering film arranged on the branch stent body, and the branch covered stent is communicated with the aortic arch section; a first puncture part and a second puncture part are arranged on the aortic arch section and located on the two sides of the branch covered stent, and the positions where the first puncture part and the second puncture part are located are only composed of the main covered film. The invention further provides an aortic arch covered stent assembly. The aortic arch covered stent and the aortic arch covered stent assembly are simple in structure and convenient to use.

A stent graft system includes a primary body having a proximal end, a distal end, a first tubular graft material and multiple stents attached to the first tubular graft material. A first branch has a second tubular graft material forming a first branch lumen. The first branch traverses a first fenestration configured in the primary body with a first wire loaded therethrough. A second branch has a third tubular graft material and a second branch lumen. The second branch traverses a second fenestration configured in the primary body with a second wire loaded therethrough. A third branch has a fourth tubular graft material and a third branch lumen. The third branch traverses a third fenestration configured in the primary body with a third wire loaded therethrough. A method for placing a stent graft system is also described.

The present invention belongs to the field of medical device technology, and specifically relates to an aortic arch filter. An aortic arch filter includes: a support structure that is bendable, hollow inside, and has openings at the distal end and the proximal end; a filter hole that is arranged on the support structure and connects the inside and outside of the support structure; and also includes: a filter screen that covers the filter hole and has an inwardly concave arc-shaped spine that is concave toward the inside of the support structure. The filter screen of the present invention adopts an inwardly concave design to form a filter screen spine. Compared with a flat filter screen design, it is not easy to deposit blood clots. The blood from the ventricle has a greater impact force. The design of the spine structure causes the blood to generate a flushing force to both sides when it impacts the filter screen, further reducing the deposition of blood clots on the filter screen and ensuring the permeability of the filter screen.

The utility model discloses an aortic arch support which comprises a body, the body is arranged to be in a pre-bending shape, a concave portion is arranged on the body, and a first branch pipe, a second branch pipe and a third branch pipe which are matched with an aortic arch are arranged on the concave portion. The first branch pipe, the second branch pipe and the third branch pipe all protrude out of the surface of the body; according to the aortic arch support, a gap can be formed between the concave part and the aortic wall, the aortic arch support is suitable for most branch variation situations, and the phenomenon that the inner diameter of the aortic trunk is reduced cannot occur; besides, the contact area of the branch blood vessel and the main blood vessel can be increased, and the contact area is changed into a surface from a point, so that the phenomenon of internal leakage is well avoided; and the aortic arch stent is integrally designed, so that the integrity of the whole stent does not need to be damaged in an operation, and the risk is low.

Disclosed are methods and devices for isolating all three of the left subclavian, left common carotid and brachiocephalic arteries from embolic debris that might flow through the aortic arch, via a single access point. A system may include an elongate flexible tubular sheath, having a proximal end and a distal end, and an inner member extending through the sheath and moveable relative to the sheath. A left subclavian element may be supported by the inner member. A filter membrane may be configured to isolate the aorta from the brachiocephalic, left common carotid and left subclavian arteries when the left subclavian element is expanded within the left subclavian artery and the sheath is retracted to expose the membrane. The left subclavian element may include a self expandable frame, which may carry a left subclavian filter.

An embolic protection device is disclosed for placement through the descending aorta and over the aortic arch to inhibit emboli release into the aortic side branch vessels while allowing simultaneous access to the aortic valve by at least one interventional and / or diagnostic catheter being introduced from the descending aorta. The filter body comprises a tubular porous mesh material and has an open upstream end to allow entry of blood flow and emboli and an open downstream end to allow entry of multiple catheters. The filter body includes at least one catheter access path parallel to said at least one passage through the filter body, and the filter body has one or more support structures or wires that provide longitudinal stiffness to the device to prevent compression or movement of the filter during a procedure.

The present invention discloses a support ring for aortic anastomosis, comprising an artificial blood vessel and a support ring. The support ring is arranged at both ends of the artificial blood vessel and sutured with the artificial blood vessel. The support ring is arc-shaped, and a plurality of elliptical first through holes are arranged on the surface of the support ring. A circle of first chamfers is arranged on the inner circumference of the first through holes. The device is used for suturing blood vessels at the positions of the ascending aorta, aortic arch and the like. The support ring is in the artificial blood vessel, the artificial blood vessel is in the aorta, and finally the three are tied and fixed with a band outside the aorta. After anastomosis, the curvature of the aorta itself can be formed and bleeding can be effectively avoided, thereby significantly reducing the anastomosis time.

A prosthetic heart valve delivery catheter includes an embolic filter to provide integrated embolic protection to inhibit the release of emboli into the aorta, the aortic arch or branch vessels, and other vasculature during transvascular heart valve replacement procedures. The embolic filter will usually be fixedly or movably attached to a shaft of the delivery catheter proximal of the prosthetic heart valve.

System, devices and methods for providing a blood-free operative region for aortic arch repair procedures. Various embodiments disclose occlusion of the descending aorta, the innominate artery, the left carotid artery and the left subclavian artery while also providing sufficient perfusion distal of the occluding balloons. Various embodiments disclose performing aortic arch repair procedures while the patient's body temperature is maintained an normothermia (about 36 degrees C to about 37.5 degrees C). Other embodiments disclose performing aortic arch repair procedures while the patient's body temperature is maintained at slight hypothermia (about 30 degrees C to about 34 degrees C).

This invention provides a covered stent and a stent assembly. The covered stent includes a first segment and two second segments respectively disposed at both axial ends of the first segment. The covered stent includes a bare stent and a covering. The bare stent includes a helical structure extending from one second segment through the first segment to the other second segment, and the helical structure has a greater ascending angle in the first segment than in the second segment. The covering covers the circumferential surface of the bare stent. The covered stent is used in a stent assembly as a branch stent for treating lesions involving the aortic arch, and it can well adapt to the anatomical structure of the aortic arch, improving treatment efficacy.

Methods of metering a pressure reflex response and pressure reflex metering devices and systems are provided herein. Such methods and devices position and expand an expandable structure at a target location within a patient vasculature, preferably an aortic arch, to meter a pressure reflex response to one or more lateral dimensions of the expandable structure. The pressure reflex metering device may optionally expand the structure to a variety of expanded configurations while monitoring the patient's blood pressure to determine an optimal dimension of the pressure reflex response. These metering devices and methods help assess the suitability of a patient to receive treatment and help select or customize implants placed in the vasculature for long term treatment of hypertension. The pressure reflex metering device may be further integrated into an implant delivery system such that partial deployment allows for metered response and full deployment allows for long term treatment.

An aortic arch brachial artery vascular stent belongs to medical consumables and is a covered stent, including a main stent and two branch stents. One end of the two branch stents is embedded in the front end of the main stent. The front end of the main stent is provided as a connector connected to the branch stent. One end of the connector is an integrated structure with the main stent, and the other end is closed and provided with a skirt extending outward. Two through holes arranged in parallel are provided in the skirt. One end of the branch stent is a connecting end, which passes through the through hole of the skirt and goes deep into the connecting end of the main stent. A limiting structure is provided at the connecting end of the branch stent. The present invention is novel in concept and ingenious in design. When applied to the innominate artery of the aortic arch, it can effectively reduce the difficulty of surgical placement of the covered stent, shorten the operation time, and improve the success rate.

To provide a heart pump assembly, also referred to as a catheter assembly, having a desired anatomical shape.SOLUTION: The catheter assembly can include a catheter and a cannula 303 having a bend between a proximal portion and a distal portion. A resting shape of the catheter and the cannula can be selected to allow the distal cannula portion to be positioned at a desired angle relative to an anatomical plane (e.g., a plane of an aortic arch). In some embodiments, a packaging tray 314 can be designed to set the catheter assembly in a desired resting shape. For example, the proximal cannula portion 308 can be positioned at a first angle relative to the catheter, and the proximal cannula portion can be positioned at a second angle out of the plane of the packaging tray via one or more inserts.SELECTED DRAWING: Figure 3