The application discloses a method and
system for jointly performing photoacoustic-
ultrasound depth resolution multilayer craniocerebral
microvessel imaging, and the method comprises the following steps: firstly, threshold
processing is performed on the amplitude of collected photoacoustic-
ultrasound data; secondly, a
single pixel value on a
scanning plane is cross-correlated with an ultrasonic
echo signal of a reference glass to determine the outer surface of the
skull, the process is repeated for all scanning points, and the inner surface of the
skull is identified in combination with a photoacoustic image; the inner and outer surfaces of the
skull in a selected region on the skull are manually segmented using the above information, the average skull thickness is calculated, then a skull angle correction uniform model is established, and the effective thickness of the skull is calculated; finally, the effective thickness of the skull is used to perform depth layer imaging on craniocerebral microvessels in a photoacoustic image. Based on the application, a fine craniocerebral
microvessel network image can be obtained, which is helpful for the analysis of craniocerebral
vascular structure and can be expected to be used in the field of medical
image analysis.