257 results about "Tunica intima" patented technology

The invention relates to the technical field of image recognition, in particular to an adhesion focus positioning method for an endometriosis rat model, which comprises the following steps of: firstly, adjusting a clustering distance according to color difference between saturation connected domains and a position inertial system, and clustering to obtain a connected domain cluster; due to the fact that the connected domain clusters contain the ectopic glands, the clusters need to be screened to obtain the ectopic glands, the gland probability of each connected domain cluster is obtained according to the characteristic that columnar epithelial cells are distributed on the inner walls of the ectopic glands, and the possibility that each connected domain cluster belongs to the ectopic glands is judged; due to the fact that the ectopic glands are distributed in a concentrated mode, the abnormal probability of the connected domain clusters is obtained through the aggregation of the connected domain clusters with the high gland probability, the possibility that the connected domain clusters belong to the abnormal ectopic glands is further judged, and the focus positioning accuracy of the endometriosis rat model is higher.

A use of a GPR1 as a target in preparing an endometriosis-related diagnostic and / or therapeutic formulation, relating to the technical field of biomedicine. The present invention provides a use of a GPR1 target as a diagnostic marker in preparing a reagent or kit for diagnosing endometriosis. The endometriosis is selected from one of uterosacral ligament endometriosis, peritoneal endometriosis, rectovaginal endometriosis, deep infiltrating endometriosis, and ovarian endometriosis. The present invention discovers that the expression of the GPR1 is significantly increased in endometriosis tissues and cells, indicating that the GPR1 can be used as a diagnostic marker for endometriosis. It has been discovered in in-vitro and in-vivo models that GPR1 knockout significantly inhibits the abilities of hEM15A cells to proliferate, migrate, and invade and the growth of ectopic foci in animals, indicating that the GPR1 can be used as a new intervention target for clinically treating endometriosis.

The invention relates to the technical field of laparoscope image labeling, in particular to a laparoscope real-time recognition method for ovarian endometriosis cyst. The method comprises the following steps: firstly, analyzing the possibility that suspected cyst areas divided by a preset segmentation model have false boundaries in combination with the position and structural features of the false boundaries, and determining a boundary correction coefficient of each suspected cyst area in each frame of image; further dividing each suspected cyst area in each frame of image into a plurality of local areas, performing fine analysis on the suspected cyst areas in combination with instrument traction and breathing influence, evaluating the cyst confidence coefficient of each local area as a micro cyst, and finally comprehensively adjusting segmentation parameters of the segmentation model to obtain a micro cyst segmentation result. Therefore, the real cyst area is accurately segmented and marked, and the recognition effect of the ovarian endometriosis cyst focus is improved.

A device adapted to monitor the follicles and to assess the thickness of the endometrium of a subject, comprises: a) an elongated member having a tip that houses an ultrasound probe; b) a handle adapted to be held in the hand of a subject; and c) a mechanism suitable to angularly displace said handle relative to said elongated member.

The invention discloses application of GPR1 as a target spot in preparation of endometriosis related diagnosis and / or treatment preparations, and belongs to the technical field of biological medicines. The invention provides application of a GPR1 target spot serving as a diagnostic marker in preparation of a reagent or a kit for diagnosing endometriosis. The endometriosis is selected from one of a uterus-sacral ligament type endometriosis, a peritoneal type endometriosis, a rectum-vagina type endometriosis, a deep infiltration type endometriosis and an ovarian type endometriosis. The invention discovers that the expression of GPR1 in endometriosis tissues and cells is obviously increased, which prompts that GPR1 can be used as a diagnostic marker of endometriosis. In-vitro and in-vivo models find that the knockout of GPR1 significantly inhibits the proliferation, migration and invasion ability of hEM15A cells and the growth of ectopic lesions in animals, indicating that GPR1 can be used as a new intervention target for clinical treatment of endometriosis.

The invention belongs to the technical field of medical apparatus and instruments, and particularly relates to a gynecological endometrium sampling device which comprises a liquid negative pressure extraction mechanism, a liquid collection and storage mechanism and a self-adaptive uterus sampling mechanism, the liquid collection and storage mechanism is fixedly arranged on the liquid negative pressure extraction mechanism, and the self-adaptive uterus sampling mechanism is fixedly arranged on the liquid negative pressure extraction mechanism. The self-adaptive uterus sampling mechanism is arranged in the liquid negative pressure extraction mechanism and is in sliding connection with the liquid negative pressure extraction mechanism; liquid in the uterus can be sucked and removed firstly, then comprehensive sampling is conducted, a sampled sample is protected and stored, the sample quality is effectively improved, and the sampling failure problem is avoided.

The invention relates to the technical field of biology, and particularly discloses a construction method and application of an endometrial epithelium organ fibrosis model. According to the method, human endometrial epithelial cells are extracted, and an endometrial epithelial organ is established by adopting a Matrigel three-dimensional culture system. Afterwards, the organoid is induced to form endometrial phenotypes in different physiological cycles through hormone stimulation, and a ferroptosis inducer FIN56 is added in the culture process to induce fibrosis. The expression of GPX4, Fibronectin and p-Smad2 / 3 is detected through Western blot and immunofluorescence, and the successful construction of the fibrosis model is verified. The invention provides an in-vitro model capable of simulating endometrial fibrosis pathological characteristics of a patient with PCOS (polycystic ovarian syndrome), the in-vitro model can be used for mechanism research and drug screening of PCOS-related endometrial lesions, and a new research tool and an intervention strategy are provided for treatment of PCOS endometrial fibrosis.

The present disclosure provides systems and methods for Al model(s) that are trained to identify characteristics associated with lesions within a blood vessel and provide a suggested procedure associated with the lesion. The Al model may receive, as input, intravascular and / or extraluminal image data associated with the blood vessel and provide, as output, characteristics, e.g., characterizations, associated with the blood vessel. The characterizations may include, for example, form or tissue nature (e.g., microcalcification, punctate, fragment, sheet, nodular, or otherwise), location within the vessel (e.g., intimal, superficial, medial, deep, etc.), size (e.g., length, depth, thickness, etc.), severity, and / or the like. The characterizations may be used as input to the same and / or a different model for providing a suggested procedure associated with the lesion. The suggested procedure may include, for example, orbital atherectomy, intravascular lithotripsy, rotational atherectomy, cutting and / or scoring balloons, and / or the like.

The invention relates to a lightweight yolov8-based endometritis classification and identification method and system, and the method comprises the steps: determining classified target historical hysteroscope image data, and enabling classification labels to comprise a normal classification group indicating normal endometrium and a lesion classification group indicating the existence of endometritis; dividing the target historical hysteroscope image data according to a preset distribution proportion to obtain training data and verification data; training data and verification data are input into a yolov8 classification model, in the training process, model lightweight processing is carried out based on weight importance pruning, quantification and knowledge distillation technologies, and feature weighting and selection based on an attention mechanism are carried out on target area features detected by yolov8 and related to endometrium and pre-acquired auxiliary modal features, so that the model weight is reduced; key feature information is extracted; and inputting real-time hysteroscope image data into the trained yov8 classification model to obtain an endometrial inflammation classification result for auxiliary diagnosis.

The invention relates to a pharmaceutical composition for treating uterine adhesion and application thereof. The kidney reinforcing and miscarriage preventing pills are used for improving endometrial blood perfusion and increasing the endometrial thickness, the kidney reinforcing and miscarriage preventing pills, aspirin and estrogen play a synergistic treatment role, the postoperative re-adhesion rate is remarkably reduced through combined treatment, and the fertility prognosis of a patient is improved; and the molecular mechanism of a TGF-beta1 pathway and EMT is deeply researched, and by inhibiting excessive activation of the TGF-beta1 signaling pathway, reducing endometrial fibrosis, regulating an epithelial-mesenchymal transition (EMT) process and promoting regeneration of endometrial epithelial cells, endometrial repair is further promoted, multi-target treatment is realized, and the treatment effect is remarkable. A brand-new and efficient treatment scheme is provided for treatment of intrauterine adhesion, an individualized treatment scheme can be formulated according to the specific conditions of patients, the treatment accuracy and effectiveness are improved, and important clinical significance and application value are achieved.

The invention discloses application of circSATB1 in preparation of a medicine for improving sheep fecundity, and belongs to the technical field of biological medicine. The nucleotide sequence of the circSATB1 is as shown in SEQ ID NO. 1. The circRNA expression profile of the sheep seminal plasma extracellular vesicles is analyzed for the first time, the expression quantity of circSATB1 in the seminal plasma extracellular vesicles is high, proliferation and migration of endometrial epithelial cells can be remarkably promoted through overexpression of circSATB1, and apoptosis of the endometrial epithelial cells is remarkably inhibited. If circSATB1 is interfered, proliferation and migration of endometrial epithelial cells can be extremely remarkably inhibited, and apoptosis of the endometrial epithelial cells can be extremely remarkably promoted. All the results prove that circSATB1 has important significance in endometrial receptivity formation, and a new thought is provided for improving the implantation rate of female livestock embryos.

The utility model discloses a balloon and an intracranial artery dilatation system. The balloon comprises a balloon body, a plurality of micropores which are formed in the balloon wall of the balloon body and communicated with an inner cavity of the balloon body, and annular protruding parts located on the two sides of the balloon body in the axial direction. After the balloon is expanded, the annular protruding parts make contact with the inner wall of the artery, so that a gap is formed between the balloon wall between the two annular protruding parts and the inner wall of the artery, and medicine flowing out of the micropores enters the gap at first. When the balloon is used, the medicine flowing out of the micropores of the balloon wall of the balloon body enters the gap firstly and does not directly act on the inner wall of the artery, so that the impact of the medicine on the inner wall of the artery can be remarkably reduced, the damage to the artery can be remarkably reduced, and the probability of injury of an inner membrane, aneurysm and acute bleeding can be remarkably reduced.

A menstrual blood-derived endometrial cell collection device is provided. [Solution] The device comprises a central hand-held hollow tube 1 and a curette function part 2. Inside are an inner limiting hollow tube and an annular stopper ring with an elastic stopper plate. A rotating knob 6 is attached to the end of the central hand-held hollow tube by a screw connection, and the inclined annular pressure ring of the rotating knob acts on the outside of the elastic stopper plate. The hollow shaft of the curette function part passes through the rotating knob and extends into the inner limiting hollow tube and is positioned by the elastic stopper plate. A friction groove is formed on the outer edge of the rotating knob. This device allows for quick replacement of the curette function part, flexible adjustment of the protrusion length, and excellent portability.

The invention provides application of injectable bioactive hydrogel in treatment of recurrent abortion, and relates to the technical field of biomedicine, and the technical key points are as follows: aldehydic hyaluronic acid and chitosan are connected in parallel, the injectable bioactive hydrogel is developed, and the hydrogel is loaded with LIF, VEGF, IL-11 and valproic acid to enhance regeneration activity. According to the application, the effect is evaluated in vitro through a specific verification experiment. Results show that the hydrogel prepared by the application shows rapid gelation, good biocompatibility and factor loading capacity, and enhances the proliferation of human endometrial stromal cells and the vascularization capacity of human umbilical vein endothelial cells. In macrophages, the expression of a proinflammatory cytokine is down-regulated, and the expression of an anti-inflammatory cytokine IL-10 is up-regulated. In conclusion, the HA-CHO / chitosan hydrogel in the application supports endometrial regeneration by synergistically promoting proliferation, angiogenesis, immune regulation and receptivity.

The utility model discloses a drainage hole with a function of preventing blood vessels from adhering to the wall. The drainage hole comprises a drainage hole body, an anti-injury block, a supporting ring, a drainage ditch and an arc-shaped cannula adhering face. A gap between every two adjacent damage blocks is a drainage ditch; each anti-damage block consists of an anti-damage table, an access slope, an access arc, an anti-damage arc I and an anti-damage arc II, wherein the anti-damage table is positioned at the upper part of the anti-damage block; the access slope is located outside the anti-damage block; the access arc is in transition connection between the access slope and the anti-damage table; the anti-damage arc I is positioned on the inner side of the anti-damage block; the anti-damage arcs II are located on the two sides of the anti-damage block. According to the utility model, the drainage holes can be effectively prevented from being blocked by endangium, so that the following problems are avoided: the treatment effect is reduced or even interrupted due to sudden drop of drainage quantity, and the life of a patient is endangered; due to the fact that drainage holes are blocked by endangium, the endangium is injured due to the high pressure difference between intravascular equipment and extracorporeal equipment; endovascular injury generates thrombus which endangers the life of a patient.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

The application provides an aortic dissection rupture sealing device, which comprises a body having a hollow flow channel extending along the axial direction of the body, the hollow flow channel penetrating the rupture for conducting the true lumen of the aorta and the branch blood vessel, and the body being used for connecting a stent located in the branch blood vessel; and an anchoring part arranged on the body and surrounding the hollow flow channel, and anchored to the surrounding intima at the rupture, so as to prevent the fluid from conducting between the true lumen and the false lumen formed at the rupture. By using the above scheme, the rupture sealing effect can be improved, the continuous expansion of the false lumen caused by the incomplete rupture sealing and the residual liquid leakage can be avoided, and the blood supply stability of the branch blood vessel can be ensured, so that the blood supply demand of the internal organs, the spinal cord and the like supplied by the branch blood vessel can be met.

The invention relates to a flexible conductive intravenous stent based on functional electrical stimulation. The invention belongs to the fields of biomedical engineering and the like. The PCL-Gr extravascular stent is prepared by utilizing an electrostatic spinning technology, and the PCL-Gr extravascular stent wraps the periphery of the transplanted vein to provide necessary mechanical support for the transplanted vein so as to maintain the structural stability of the transplanted vein, so that the risk of restenosis caused by hemodynamic change is reduced. And meanwhile, functional electrical stimulation is accurately applied to transplanted veins by utilizing conductivity, so that double mechanisms of promoting endothelialization and inhibiting smooth muscle cell proliferation are achieved, and the risk of intimal hyperplasia is effectively reduced.

The application provides a pulmonary artery tissue-derived cell, an organoid and a construction method and application thereof. The pulmonary artery intimal stripping tissue organoid structure obtained by the preparation method is clear, has consistent cell types as the source tissue, is close to the original tissue, is convenient for researchers to operate, and thus has good practical application value.

The invention relates to an intravascular stent for regulating neutrophil phenotype and a preparation method of the intravascular stent, and belongs to the technical field of cardiovascular implant materials. Specifically, a polymer coating for loading a neutrophil chemotactic active substance and a neutrophil phenotype regulation substance is formed on the outer wall of the intravascular stent. The coating can induce neutrophile granulocytes collected due to intimal mechanical injury caused by intravascular stent implantation to infiltrate into a focus and convert to N2 phenotype. Then, the neutrophil exerts an upstream immune regulation effect, induces the macrophages to be converted from a pro-inflammatory M1 type to a repair-promoting M2 type, further secretes repair-promoting related factors, improves an immune microenvironment related to endangium tissue regeneration and repair, realizes stent surface endothelialization, and finally realizes endangium tissue regeneration and repair.

The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.

The invention relates to the field of animal models, in particular to a construction method and application of an experimental animal plaque model.The construction method includes the steps that after blood flow is blocked through a balloon method, induction is conducted by directly infiltrating a calcium chloride solution into an endarterium, and finally an artery blood vessel calcified plaque model is formed; therefore, an experimental animal model with high efficiency, repeatability, minimally invasive property and pathological correlation is provided for the research of the artery blood vessel calcified plaque.

The invention relates to the technical field of medical artificial intelligence monitoring, and discloses an intelligent monitoring method and system for a perfusion curative effect of a thin endometrial rich microplate. The method comprises the following steps: standardizing and fusing multi-source monitoring data, constructing a derivative feature set reflecting a treatment coordination rule through cross-cycle feature derivation, and establishing a curative effect behavior coding library according to the derivative feature set. After the real-time data is subjected to standardization processing, frame-by-frame mode matching and similarity calculation are carried out on the real-time data and a coding library, a corresponding analysis path is activated according to a result, and a curative effect behavior fragment with a timestamp is generated. The segments are associated and aggregated to form a complete curative effect event chain, key turning points are marked, and finally a structured monitoring report and a decision signal are generated through multi-dimensional influence evaluation. According to the invention, the conversion from static parameter judgment to dynamic curative effect behavior intelligent analysis is realized, and the continuity, accuracy and early warning capability of treatment process monitoring are improved.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

Embodiments of catheters, methods, and devices for endovascular treatment of a blood vessel uses a catheter. The catheter includes a catheter body including a distal end and a distal tip assembly (100) movably connected to the catheter body at the distal end of the catheter body. The distal tip assembly includes a plurality of tips (102. 104. 106) that nest together and of which each comprises a fistula forming element and a support shaft. At least one of the plurality of tips is independently movable relative to an adjacent one of the plurality of tips between a retracted position and an extended position to provide a treatment region therebetween. WO

The application relates to the application of lycorine hydrochloride in the preparation of a medicine for inhibiting the proliferation of a neointimal in a blood vessel. Lycorine hydrochloride has the effect of inhibiting the proliferation of a neointimal in a blood vessel, and the effect is mainly realized by inhibiting the proliferation and migration of vascular smooth muscle cells. In the body, the results show that lycorine hydrochloride can significantly inhibit the intimal proliferation caused by left common carotid artery ligation, and in vitro experiments prove that lycorine hydrochloride can intervene in the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB. Lycorine hydrochloride inhibits the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB, and the proliferation of a neointimal in a blood vessel through a MAPKs signal path. The application provides data for preparing lycorine hydrochloride into a medicine for inhibiting the proliferation of a neointimal in a blood vessel, and is expected to be applied to the prevention and treatment of complications after percutaneous coronary intervention, such as restenosis or in-stent thrombosis, and can become a potential medicine for intervening in restenosis.

The utility model discloses an auxiliary device for raising the maxillary sinus intima, and particularly relates to the technical field of maxillary sinus intima, which comprises a shell, a raising head for raising the maxillary sinus intima is fixedly arranged at the top of the shell, a silica gel block is fixedly embedded at the top of the raising head, air outlet holes are arranged at the top of the silica gel block and the top of the raising head, and the air outlet holes are communicated with the shell. A plurality of air outlets are formed in the outer side wall of the silica gel block and communicate with the air outlet hole, and a cavity is formed in the top of the shell and communicates with the air outlet hole. The shell and the lifting head move upwards, the silica gel block on the lifting head is used for jacking up the maxillary sinus intima, lifting of the maxillary sinus intima is achieved, then the push rod is pushed to drive the round plug to push bone meal in the cavity into the air outlet hole, and the bone meal is scattered into the maxillary sinus through the air outlet hole and the air outlet. And the space between the maxillary sinus intima and the maxillary sinus can be filled, so that the maxillary sinus intima is lifted, the structure is simple, and the use is very convenient.

To provide a catheter device and retrieval method that can reduce the burden on blood vessels. [Solution] The catheter device according to this disclosure is characterized by comprising a peeling mechanism 4 that peels the intima 21 to which the lesion 20 is attached from the media 22 by supplying liquid between the intima 21 and the media 22 of the blood vessel 2 through a crack (first crack 25) formed in the intima 21 of the blood vessel 2. The intima 21 is easily peeled from the media 22 by the pressure of the liquid that flows between the intima 21 and the media 22. Therefore, it is not necessary to bring the peeling mechanism 4 or other instrument into contact with the blood vessel 2 in order to peel the intima 21. Moreover, it is possible to prevent the inconvenience of removing the media 22 when removing the intima 21. As a result, the burden on the blood vessel 2 can be reduced.

The utility model provides a kind of vascular stent, the device includes: first support, first support includes first support unit and first pipe body, first support unit is set on first pipe body, along the length direction of first pipe body extends, and stop and resist the outside wall of first pipe body, first pipe body is distributed with multiple first hollow holes of interval distribution;Second support, second support includes second support unit and second pipe body, second support unit is set on second pipe body, along the length direction of second pipe body extends, and stop and resist the outside wall of second pipe body, second pipe body is distributed with multiple second hollow holes of interval distribution;The end of second support is connected with first support, the lumen of first pipe body is communicated with the lumen of second pipe body.In the utility model, sufficient radial support force is provided while excellent flexibility is guaranteed, the mechanical stress stimulation to blood vessel intima is small, and the long-term patency of main branch and side branch is guaranteed.

The invention discloses a culture method based on posthypoxia gastric intima separation treatment of freshwater white pomfret, and relates to the technical field of aquaculture and disease prevention and control. The method comprises the following steps: step 1, identifying hypoxia symptoms; 2, medicine compatibility feeding is carried out; 3, regulating and controlling the water body environment; 4, breeding environment management; and step 5, continuous monitoring. According to the invention, the food maternal, the endothelium corneum gigeriae galli and the pipemidic acid are combined for the separation treatment of the endogastric membranes of the aquatic animals for the first time, the thinking limitation of traditional disease prevention and treatment is broken through, the traditional Chinese and western medicine theories are organically combined, and a new disease prevention and treatment thought is provided for the aquaculture industry; compared with a traditional pure antibiotic treatment or water quality improvement method, the scheme is high in pertinence and directly aims at a core pathological link of gastric intima separation after hypoxia; the comprehensive treatment effect is good, and meanwhile, anti-infection, mucous membrane repair and function regulation are considered; and the used medicines are all common medicines, have small side effects and low residues, and meet the safety requirements of aquatic products.