157 results about "Tunica intima" patented technology

A device adapted to monitor the follicles and to assess the thickness of the endometrium of a subject, comprises: a) an elongated member having a tip that houses an ultrasound probe; b) a handle adapted to be held in the hand of a subject; and c) a mechanism suitable to angularly displace said handle relative to said elongated member.

The present disclosure provides systems and methods for Al model(s) that are trained to identify characteristics associated with lesions within a blood vessel and provide a suggested procedure associated with the lesion. The Al model may receive, as input, intravascular and / or extraluminal image data associated with the blood vessel and provide, as output, characteristics, e.g., characterizations, associated with the blood vessel. The characterizations may include, for example, form or tissue nature (e.g., microcalcification, punctate, fragment, sheet, nodular, or otherwise), location within the vessel (e.g., intimal, superficial, medial, deep, etc.), size (e.g., length, depth, thickness, etc.), severity, and / or the like. The characterizations may be used as input to the same and / or a different model for providing a suggested procedure associated with the lesion. The suggested procedure may include, for example, orbital atherectomy, intravascular lithotripsy, rotational atherectomy, cutting and / or scoring balloons, and / or the like.

A menstrual blood-derived endometrial cell collection device is provided. [Solution] The device comprises a central hand-held hollow tube 1 and a curette function part 2. Inside are an inner limiting hollow tube and an annular stopper ring with an elastic stopper plate. A rotating knob 6 is attached to the end of the central hand-held hollow tube by a screw connection, and the inclined annular pressure ring of the rotating knob acts on the outside of the elastic stopper plate. The hollow shaft of the curette function part passes through the rotating knob and extends into the inner limiting hollow tube and is positioned by the elastic stopper plate. A friction groove is formed on the outer edge of the rotating knob. This device allows for quick replacement of the curette function part, flexible adjustment of the protrusion length, and excellent portability.

The utility model discloses a drainage hole with a function of preventing blood vessels from adhering to the wall. The drainage hole comprises a drainage hole body, an anti-injury block, a supporting ring, a drainage ditch and an arc-shaped cannula adhering face. A gap between every two adjacent damage blocks is a drainage ditch; each anti-damage block consists of an anti-damage table, an access slope, an access arc, an anti-damage arc I and an anti-damage arc II, wherein the anti-damage table is positioned at the upper part of the anti-damage block; the access slope is located outside the anti-damage block; the access arc is in transition connection between the access slope and the anti-damage table; the anti-damage arc I is positioned on the inner side of the anti-damage block; the anti-damage arcs II are located on the two sides of the anti-damage block. According to the utility model, the drainage holes can be effectively prevented from being blocked by endangium, so that the following problems are avoided: the treatment effect is reduced or even interrupted due to sudden drop of drainage quantity, and the life of a patient is endangered; due to the fact that drainage holes are blocked by endangium, the endangium is injured due to the high pressure difference between intravascular equipment and extracorporeal equipment; endovascular injury generates thrombus which endangers the life of a patient.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

The application provides an aortic dissection rupture sealing device, which comprises a body having a hollow flow channel extending along the axial direction of the body, the hollow flow channel penetrating the rupture for conducting the true lumen of the aorta and the branch blood vessel, and the body being used for connecting a stent located in the branch blood vessel; and an anchoring part arranged on the body and surrounding the hollow flow channel, and anchored to the surrounding intima at the rupture, so as to prevent the fluid from conducting between the true lumen and the false lumen formed at the rupture. By using the above scheme, the rupture sealing effect can be improved, the continuous expansion of the false lumen caused by the incomplete rupture sealing and the residual liquid leakage can be avoided, and the blood supply stability of the branch blood vessel can be ensured, so that the blood supply demand of the internal organs, the spinal cord and the like supplied by the branch blood vessel can be met.

The application provides a pulmonary artery tissue-derived cell, an organoid and a construction method and application thereof. The pulmonary artery intimal stripping tissue organoid structure obtained by the preparation method is clear, has consistent cell types as the source tissue, is close to the original tissue, is convenient for researchers to operate, and thus has good practical application value.

The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.

The invention relates to the technical field of medical artificial intelligence monitoring, and discloses an intelligent monitoring method and system for a perfusion curative effect of a thin endometrial rich microplate. The method comprises the following steps: standardizing and fusing multi-source monitoring data, constructing a derivative feature set reflecting a treatment coordination rule through cross-cycle feature derivation, and establishing a curative effect behavior coding library according to the derivative feature set. After the real-time data is subjected to standardization processing, frame-by-frame mode matching and similarity calculation are carried out on the real-time data and a coding library, a corresponding analysis path is activated according to a result, and a curative effect behavior fragment with a timestamp is generated. The segments are associated and aggregated to form a complete curative effect event chain, key turning points are marked, and finally a structured monitoring report and a decision signal are generated through multi-dimensional influence evaluation. According to the invention, the conversion from static parameter judgment to dynamic curative effect behavior intelligent analysis is realized, and the continuity, accuracy and early warning capability of treatment process monitoring are improved.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

Embodiments of catheters, methods, and devices for endovascular treatment of a blood vessel uses a catheter. The catheter includes a catheter body including a distal end and a distal tip assembly (100) movably connected to the catheter body at the distal end of the catheter body. The distal tip assembly includes a plurality of tips (102. 104. 106) that nest together and of which each comprises a fistula forming element and a support shaft. At least one of the plurality of tips is independently movable relative to an adjacent one of the plurality of tips between a retracted position and an extended position to provide a treatment region therebetween. WO

The application relates to the application of lycorine hydrochloride in the preparation of a medicine for inhibiting the proliferation of a neointimal in a blood vessel. Lycorine hydrochloride has the effect of inhibiting the proliferation of a neointimal in a blood vessel, and the effect is mainly realized by inhibiting the proliferation and migration of vascular smooth muscle cells. In the body, the results show that lycorine hydrochloride can significantly inhibit the intimal proliferation caused by left common carotid artery ligation, and in vitro experiments prove that lycorine hydrochloride can intervene in the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB. Lycorine hydrochloride inhibits the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB, and the proliferation of a neointimal in a blood vessel through a MAPKs signal path. The application provides data for preparing lycorine hydrochloride into a medicine for inhibiting the proliferation of a neointimal in a blood vessel, and is expected to be applied to the prevention and treatment of complications after percutaneous coronary intervention, such as restenosis or in-stent thrombosis, and can become a potential medicine for intervening in restenosis.

To provide a catheter device and retrieval method that can reduce the burden on blood vessels. [Solution] The catheter device according to this disclosure is characterized by comprising a peeling mechanism 4 that peels the intima 21 to which the lesion 20 is attached from the media 22 by supplying liquid between the intima 21 and the media 22 of the blood vessel 2 through a crack (first crack 25) formed in the intima 21 of the blood vessel 2. The intima 21 is easily peeled from the media 22 by the pressure of the liquid that flows between the intima 21 and the media 22. Therefore, it is not necessary to bring the peeling mechanism 4 or other instrument into contact with the blood vessel 2 in order to peel the intima 21. Moreover, it is possible to prevent the inconvenience of removing the media 22 when removing the intima 21. As a result, the burden on the blood vessel 2 can be reduced.

The invention discloses a culture method based on posthypoxia gastric intima separation treatment of freshwater white pomfret, and relates to the technical field of aquaculture and disease prevention and control. The method comprises the following steps: step 1, identifying hypoxia symptoms; 2, medicine compatibility feeding is carried out; 3, regulating and controlling the water body environment; 4, breeding environment management; and step 5, continuous monitoring. According to the invention, the food maternal, the endothelium corneum gigeriae galli and the pipemidic acid are combined for the separation treatment of the endogastric membranes of the aquatic animals for the first time, the thinking limitation of traditional disease prevention and treatment is broken through, the traditional Chinese and western medicine theories are organically combined, and a new disease prevention and treatment thought is provided for the aquaculture industry; compared with a traditional pure antibiotic treatment or water quality improvement method, the scheme is high in pertinence and directly aims at a core pathological link of gastric intima separation after hypoxia; the comprehensive treatment effect is good, and meanwhile, anti-infection, mucous membrane repair and function regulation are considered; and the used medicines are all common medicines, have small side effects and low residues, and meet the safety requirements of aquatic products.

Provided are human therapeutic compositions including a compound comprising a plurality of fused polycyclic moieties and a linker moiety. In certain embodiments, the compound is a reaction product of an aldehyde and a harmine component. The compositions exhibit anti-cancer properties, particularly against lymphoma, leukemia, pancreatic, endometrial, ovarian, gastric, breast, renal, cervical, head and neck, and myeloma cell lines.

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

The present application relates to the application of delta-Viniferin in the preparation of drugs for preventing or treating metabolic cardiovascular diseases. Delta-Viniferin can inhibit the expression level of aging and inflammation related genes / proteins of vascular endothelial cells, reduce endothelial dysfunction, and clarify its anti-hypertensive effect. Delta-Viniferin can inhibit the expression level of vascular smooth muscle cell phenotype conversion related genes / proteins, improve the contraction function of vascular smooth muscle, and significantly alleviate the degradation of elastic fibers of the vascular wall and the rupture of the intima of the aortic wall in vivo, and clarify its effect on preventing and treating aortic dissection. Delta-Viniferin can inhibit the expression level of myocardial fibroblast fibrosis related genes / proteins, and clarify its anti-myocardial fibrosis effect. Delta-Viniferin can promote white adipose tissue browning by targeting the SIRT1-FOXO1 axis, increase energy consumption, and clarify its effect on resisting obesity. In summary, the compound delta-Viniferin has the effect of protecting various metabolic cardiovascular diseases, and can be used to prepare drugs for preventing and treating metabolic cardiovascular diseases.

The present disclosure relates generally to the use of medical devices for treating vascular disease. In particular, the present disclosure provides devices and methods for using laser-induced pressure waves generated within a sheath to disrupt intimal and medial calcium within a vessel.

This invention belongs to the field of medical devices and discloses a vascular rupture sealing device, including a sealing assembly and a driving assembly. The sealing assembly includes a first sealing part, a second sealing part, and an elastic sealing component. This invention enables the elastic sealing component to deform outwards when the first and second sealing parts compress it. This deformation causes the pressing part to extend outwards. The thickening reduces the rolling effect, allowing the pressing parts at both ends to move relative to each other and press against both sides of the aortic intima for sealing. Furthermore, the smaller diameter before deformation facilitates insertion into the rupture, making installation convenient, the structure simpler, and more effective.

The invention discloses application of C3 and / or C3a and / or C3aR as a target spot in preparation of a preparation for diagnosing and / or treating diseases related to endometriosis, relates to the technical field of biological medicines, and provides application of C3 and / or C3a and / or C3aR as a target spot in preparation of a preparation for diagnosing and / or treating diseases related to endometriosis. The endometriosis comprises a uterus-sacral ligament type endometriosis, a peritoneal type endometriosis, a rectum-vagina type endometriosis, a deep infiltration type endometriosis, an ovarian type endometriosis, an abdominal wall incision type endometriosis, a perineum incision type endometriosis and a lung type endometriosis; and at least one of nasal endometriosis. The endometriosis can be diagnosed by detecting the content of at least one of C3, C3a and C3aR; the C3 and / or C3a and / or C3aR inhibitor can be used for reducing the focus and treating the endometriosis.

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.

This invention provides a cutting device and a cutting system. The cutting device includes an expandable structure having a radially expanded state and a radially contracted state, for fitting over the balloon of a balloon catheter. The expandable structure includes a cutting portion and a flexible portion along its axial direction, the flexible portion being connected to the axial end of the cutting portion. The cutting device and cutting system of this invention can reduce the probability of disordered tearing of the vascular intima by the balloon, thereby reducing the probability of flow-limiting dissection.

The application discloses a medical instrument technical field, and relates to an embryo transfer device, which comprises a sleeve, an inner core and a syringe, the inner core is detachably connected with the syringe, the tail section of the inner core is provided with a circular arc structure at an opening, the thickness of the tube wall of the opening is gradually reduced from the opening to the tail section, and the inner wall of the tube wall of the opening is provided with a funnel structure; the syringe comprises a barrel, a pressurizing barrel is connected to the barrel, the inner diameter of the inner cavity of the barrel is smaller than the inner diameter of the inner cavity of the pressurizing barrel, a piston plate is arranged in the barrel, the piston plate is in sliding fit with the inner wall of the barrel, the pressurizing barrel is in communication with the barrel, a push plate is arranged in the pressurizing barrel, a push rod is connected to one side of the push plate, and the push rod penetrates through the pressurizing barrel. The special syringe is designed, the syringe and the inner core are used in cooperation, the embryo can be better controlled in suction and injection, the damage to the endometrium is reduced, the success rate and safety of embryo transfer are improved, and better treatment options are provided for infertile patients.

This invention relates to a vascular stent for the visceral region of the abdominal aorta, comprising an interconnected proximal non-degradable segment and a distal degradable segment. The proximal non-degradable segment includes a non-degradable metal skeleton and a covering structure. The distal degradable segment is a degradable bare skeleton. The proximal non-degradable segment corresponds to the location of the primary tear in the visceral region of the abdominal aorta, and the distal degradable segment corresponds to the location of branch vessels in the visceral region of the abdominal aorta. This invention is applicable to abdominal aortic dissection anatomical features, where the proximal stent segment is non-degradable and covered, while the distal visceral segment is degradable but not covered. It promotes false lumen thrombosis by sealing the primary tear through covering, while maintaining patency of branch vessels in the visceral segment by not covering. Simultaneously, a drug layer is attached to the covering of the proximal stent segment to actively promote intimal repair.

The invention relates to the technical field of medical instruments, in particular to a common carotid artery piercing sheath with an inflatable balloon, which comprises a first catheter and a second catheter, the first catheter is communicated with the second catheter, and the first catheter is used for being inserted into an artery and used for guiding blood in the artery to enable the blood to flow into the second catheter; a limiting assembly is arranged on the outer side wall of the first catheter and is used for inserting the first catheter into a blood vessel and blocking and closing the blood vessel; the tail end of the second catheter is connected with an adjusting assembly, and the other end, away from the first catheter, of the second catheter is connected with an external conveying pipe. The air bag is divided into a plurality of independent inflation cavities by the diaphragms, and can be inflated and expanded in a partitioned mode in sequence, so that the air bag can adapt to the shape of a blood vessel, uniform sealing attached to the wall of the blood vessel is achieved, and local compression or incomplete sealing caused by deviation of the air bag is avoided; suddenly impact of one-time overall expansion of a traditional air bag on the blood vessel wall is avoided through partitioned inflation, and the risk of injury or spasm of the endangium is reduced.

The present disclosure provides systems and methods for determining an external elastic lamina (“EEL”) value for intravascular image frames and using the predicted EEL to determine a plaque burden for respective image frames. The predicted EEL value may be determined based on a threshold number of image frames within a region of interest having plaque burden below a threshold plaque burden. In some examples, the predicted EEL value may be determined as a function of intima thickness and media thickness and the H-K model derived expected lumen diameter. The determined plaque burden and visible EEL arc may be used to automatically identify lesions and suggest candidate treatment zones.

The invention discloses a left iliac total vein extravascular stent and an operation method, and belongs to the field of medical instruments. The stent comprises a middle section connecting sleeve frame, an inferior vena cava sleeve frame and a left iliac vein sleeve frame which are integrally formed, the included angle between the three is 135-145 degrees, an elastic silica gel limiting clamping belt is arranged and made of a silicon rubber material, and the crosslinking density and flexibility are regulated and controlled by adjusting the vinyl content. The surgical method comprises the following steps of: minimally invasive laparoscopic approach, implanting a stent after exposing a target blood vessel, and adjusting the position. Direct contact between the built-in stent and the intima is avoided, the intima hyperplasia and thrombus risks are reduced, fatigue resistance and creep resistance are achieved, the stent is attached to the anatomical structure, fixation is stable, minimally invasive recovery is fast, customizable adaptation can be achieved, and the clinical treatment effect and safety are improved.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a sperm-nourishing seed jade decoction and application thereof to improvement of endometrial receptivity, the sperm-nourishing seed jade decoction is composed of 30 g of radix rehmanniae preparata, 15 g of cornus officinalis, 15 g of radix paeoniae alba and 15 g of angelica sinensis, by inhibiting the epithelial-mesenchymal transition (EMT) process, the expression of E-cadherin and beta-catenin is up-regulated, the expression of Vimentin is down-regulated, and the endometrial receptivity is improved. Therefore, the stability and integrity of endometrial epithelium are maintained, intimal thickening, gland hyperplasia and angiogenesis are promoted, and an effective treatment strategy can be provided for infertility caused by thin endometrium.

The invention relates to the technical field of biomedicine, in particular to a group of key biomarkers for predicting endometrial receptivity, including specific microbial strains and metabolites, and a prediction model containing the markers. The method comprises the following steps: collecting a uterine cavity lavage fluid sample, carrying out 16S rRNA gene sequencing and non-targeted metabonomics analysis, and screening out eight key microbial strains and eight key metabolites; based on the markers, the following diagnostic models are constructed: a model only based on eight microbial strains; a model based on only eight metabolites; a combined microorganism and metabolite model; and a clinical data model is further combined. According to the method, a microbiome and metabolome multi-omics conjoint analysis strategy is adopted, strict screening is carried out in combination with LASSO regression, SVM-RFE and other machine learning algorithms, and the obtained biomarker is high in specificity. The constructed model, especially a combined model, shows high prediction precision and good calibration degree through verification of various curves.

The invention discloses a chest catheter expansion stent and an expansion stent system, and belongs to the technical field of medical instruments, the chest catheter expansion stent comprises a cylindrical grid stent section and a flower-shaped stent section, the cylindrical grid stent section is used for being implanted into a chest catheter arch, and the flower-shaped stent section is used for being indwelled in veins; the flower-shaped stent section comprises hollowed-out petals arranged in the circumferential direction, and the hollowed-out petals are bent towards the far end of the cylindrical grid stent section. The dilation stent system comprises a conveying device and a chest catheter dilation stent. The near end of the thoracic duct expansion stent is in a flower shape, hollow petals are bent outwards, the thoracic duct-vein angle tissue can be attached more tightly, the contact area is increased, radial stress is dispersed, progressive supporting force is provided, stent displacement is avoided, a good anchoring effect is achieved, and the stability of the thoracic duct expansion stent is improved. The continuous injury to the intravenous intima is reduced, the thrombus risk is reduced, the elastic retraction of the chest catheter wall is effectively resisted, and the restenosis is prevented from the source of mechanical design.