36 results about "Tunica intima" patented technology

The application provides a pulmonary artery tissue-derived cell, an organoid and a construction method and application thereof. The pulmonary artery intimal stripping tissue organoid structure obtained by the preparation method is clear, has consistent cell types as the source tissue, is close to the original tissue, is convenient for researchers to operate, and thus has good practical application value.

The application relates to the application of lycorine hydrochloride in the preparation of a medicine for inhibiting the proliferation of a neointimal in a blood vessel. Lycorine hydrochloride has the effect of inhibiting the proliferation of a neointimal in a blood vessel, and the effect is mainly realized by inhibiting the proliferation and migration of vascular smooth muscle cells. In the body, the results show that lycorine hydrochloride can significantly inhibit the intimal proliferation caused by left common carotid artery ligation, and in vitro experiments prove that lycorine hydrochloride can intervene in the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB. Lycorine hydrochloride inhibits the proliferation, migration and phenotype transformation of VSMCs induced by PDGF-BB, and the proliferation of a neointimal in a blood vessel through a MAPKs signal path. The application provides data for preparing lycorine hydrochloride into a medicine for inhibiting the proliferation of a neointimal in a blood vessel, and is expected to be applied to the prevention and treatment of complications after percutaneous coronary intervention, such as restenosis or in-stent thrombosis, and can become a potential medicine for intervening in restenosis.

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.

This invention provides a cutting device and a cutting system. The cutting device includes an expandable structure having a radially expanded state and a radially contracted state, for fitting over the balloon of a balloon catheter. The expandable structure includes a cutting portion and a flexible portion along its axial direction, the flexible portion being connected to the axial end of the cutting portion. The cutting device and cutting system of this invention can reduce the probability of disordered tearing of the vascular intima by the balloon, thereby reducing the probability of flow-limiting dissection.

This invention relates to a vascular stent for the visceral region of the abdominal aorta, comprising an interconnected proximal non-degradable segment and a distal degradable segment. The proximal non-degradable segment includes a non-degradable metal skeleton and a covering structure. The distal degradable segment is a degradable bare skeleton. The proximal non-degradable segment corresponds to the location of the primary tear in the visceral region of the abdominal aorta, and the distal degradable segment corresponds to the location of branch vessels in the visceral region of the abdominal aorta. This invention is applicable to abdominal aortic dissection anatomical features, where the proximal stent segment is non-degradable and covered, while the distal visceral segment is degradable but not covered. It promotes false lumen thrombosis by sealing the primary tear through covering, while maintaining patency of branch vessels in the visceral segment by not covering. Simultaneously, a drug layer is attached to the covering of the proximal stent segment to actively promote intimal repair.

The present application relates to the technical field of endoscopes. Disclosed are a drug release device and an endoscopic assembly. The drug release device comprises a first tube, a balloon and a light-emitting structure. The balloon is configured as a light-transmissive and expandable structure, and a structural layer of the balloon encloses an inner cavity, such that the inner cavity and the distal end of the first tube are sealed and are in communication with each other. Moreover, the first tube extends into the inner cavity, and then the light-emitting structure is provided in the balloon. Light emitted by the light-emitting structure and a photosensitive cross-linked drug composite layer located outside the structural layer are used to induce a cross-linking reaction. After the balloon is inserted into the uterus, a liquid can be injected into the balloon through the first tube so as to expand the balloon, and the expanded balloon can abut against the endometrium. After the light-emitting structure emits light, the photosensitive cross-linked drug composite layer can adhere to the surface of the endometrium, thereby enabling a drug contained in the photosensitive cross-linked drug composite layer to fully and tightly attach to the endometrium for the continuous treatment or repair of the endometrium.

The utility model relates to a detachable papillary balloon and balloon catheter, including inner layer balloon, outer layer balloon, convex part structure, the fluid passage is formed between outer layer balloon, inner layer balloon, is provided with the hole on outer layer balloon, the convex part structure includes convex part main part, barb, drug loading membrane, the hole of outer layer balloon is blocked up with convex part main part being connected on outer layer balloon, the barb is connected on convex part main part, the drug loading membrane is coated on convex part main part and / or barb, when fluid acts on convex part main part through fluid passage, hole, convex part main part can be separated from outer layer balloon. The utility model utilizes the feature that the convex part structure is less in contact with calcified lesion or narrow site, plays the pressure amplification effect, and better expands and crushes plaque, through the separation of the convex part structure and the balloon, the separated convex part structure is anchored in the vascular intima, thereby continuously administering, short residence time, long administration duration, and better treatment effect.

An apparatus configured to facilitate delivery of an embryo to an implantation site on an endometrium of a patient is provided. The apparatus comprises one or more walls defining a cavity, the walls comprising a rim configured for adhering to the endometrium and defining an opening to the cavity. The walls comprise one or more throughgoing apertures, each sized to allow passage therethrough of intrauterine environmental molecules, and to prevent passage therethrough of a blastocyst. The material of the walls is configured to degrade in the intrauterine environment within a predetermined range of time.

The application relates to the field of biological medicine, in particular to a medicine for preventing intimal hyperplasia and application thereof, and specifically discloses application of a plasmid in preparation of a medicine for preventing intimal hyperplasia through extra-vascular injection, wherein the plasmid is one or more of HGF plasmid, VEGF plasmid and eNOS plasmid, and the plasmid is a naked plasmid. Through the scheme, a medicine of a safe, simple, efficient and local continuous expression gene delivery mode is developed, the medicine is precisely delivered from outside to inside through an extra-vascular injection path, the problems of easy loss of intraluminal medicine and poor targeting of systemic administration are solved, and the treatment effect of the disease is greatly improved.

This invention discloses a chitosan-based wound adhesive for promoting healing and inhibiting scarring, and its preparation method. The adhesive employs a time-controlled release structure: an outer layer is a chitosan-Imperata cylindrica inflammatory response coating, and an inner layer is a polylactic acid-egg membrane, loaded with tranexamic acid and onion extract liposomes. Upon contact with wound exudate, the outer layer can solidify in situ in response to salt, rapidly stopping bleeding and relieving pain; in the acidic inflammatory microenvironment, the inner layer gradually degrades, with the egg membrane and tranexamic acid synergistically promoting epithelial regeneration and improving scar quality; onion extract inhibits excessive fibroblast proliferation and regulates orderly collagen deposition, preventing hypertrophic scars and pigmentation from the source. This invention primarily uses natural biomaterials, exhibiting excellent biocompatibility, and simultaneously achieves hemostasis, anti-inflammation, healing promotion, and scar inhibition throughout the entire treatment cycle, overcoming the shortcomings of traditional dressings such as uncontrollable drug release and limited functionality.

The application discloses a thrombus taking device with a composite mesh structure, a support body of which adopts a woven structure and is arranged in a multi-segment structure and comprises a support outer layer and an inner layer. The outer layer is a large-mesh thrombus embedding structure, which is beneficial to the large thrombus to burst in to provide strong anchoring force and realize efficient embedding; the inner layer is a small-mesh leakage prevention structure, which is used for intercepting the thrombus fragments falling off in the thrombus taking process and preventing secondary embolism. The thrombus taking device takes into account the embedding and leakage prevention of the thrombus through the composite mesh structure, and the success rate and safety of thrombus taking are improved. The woven structure and the multi-segment design reduce the contact area and pulling damage of the support and the blood vessel wall, the soft spring arranged at the distal end can buffer the contact stress and reduce the risk of blood vessel intima damage. Meanwhile, the small-mesh independent unit of the inner layer, the multi-segment leakage prevention thrombus bundle port or the double-layer leakage prevention thrombus structure enhances the radial support force of the middle part of the woven support, guarantees the adhesion and embedding stability of the woven support in the tortuous blood vessel, avoids the displacement of the support or the falling off of the thrombus, and is beneficial to improving the prognosis of patients.

This invention relates to the pharmaceutical field, specifically to a drug for the prevention or treatment of endometrial fibrosis, comprising poloxamer and spermidine; poloxamer is added to the spermidine solution and swelled at 3-5°C until completely dissolved to form a liquid precursor; the liquid precursor undergoes a phase transition at 35-40°C to form a gel; the liquid precursor is injected into the uterine cavity to reduce the expression of αSMA in the endometrial tissue, inhibit the transformation of stromal cells into myofibroblasts, and promote angiogenesis.

Devices and methods for exploiting intramural (e.g., subintimal) space of a vascular wall to facilitate the treatment of vascular disease, particularly total occlusions. For example, the devices and methods disclosed herein may be used to visually define the vessel wall boundary, protect the vessel wall boundary from perforation, bypass an occlusion, and / or remove an occlusion.

A hysteroscopic specimen collection device includes a connecting piece and a collection bag. The connecting piece has an operating through hole and a first adhesive layer on its back. The lower end of the connecting piece is connected to the opening side of the collection bag. A first filter and a second filter are installed sequentially from top to bottom inside the collection bag. The first filter is detachably installed inside the collection bag. The diameter of some filter holes in the second filter is smaller than the diameter of some filter holes in the first filter. A fixing plate is provided on the back of the connecting piece or the collection bag to assist in fixing the collection device during use. The first and second filters of this invention facilitate the separation of tissue specimens and distension fluid flowing into the collection bag, enabling specimen collection and separation of specimens of different sizes, such as easily separating uterine fibroid tissue and endometrial tissue. The first adhesive layer and the fixing plate together fix the collection device. The overall structure is simple, convenient, and practical.

This invention relates to an endometrial cell collector, comprising an outer sheath, a sampling handle, and sampling brushes. The sampling handle is inserted inside the outer sheath, with one end extending out of the sheath. Multiple sampling brushes are arranged side-by-side, each rotatably mounted within the sampling handle and radially arranged along it. The length of each sampling brush is greater than the length of the sampling handle, with both ends extending out of the handle. Each sampling brush has a brush head at one end. When the sampling handle approaches the outer sheath axially, the brush head extends out of the sheath, and the extended brush heads are arranged in a fan shape to expand the contact area with the uterine cavity, reaching both uterine horns. The multiple sampling brushes arranged side-by-side within the outer sheath can extend and retract under the push and pull of the sampling handle. The fan-shaped arrangement of the extended brush heads ensures coverage throughout the entire uterine cavity, preventing missed sampling.

The application belongs to the technical field of genetic engineering and cardiovascular disease treatment, and specifically discloses application of an expression inhibitor of a TSPAN4 gene in preparation of a drug for treating cardiovascular diseases and the drug containing the expression inhibitor of the TSPAN4 gene. The application first constructs a carotid artery injury mouse model, and research finds that the expression absence of TSPAN4 has a significant improvement effect on intimal neogenesis. Further, the expression of the TSPAN4 gene is inhibited through siRNA interference RNA technology targeting the TSPAN4 gene, and it is found that after being treated by human h-siTSPAN4, the phenotype of smooth muscle cells can be changed, and the purpose of treating cardiovascular diseases can be achieved. The method of the application can inhibit the expression of the TSPAN4 gene by delivering siRNA, so as to inhibit the proliferation and migration of abnormal smooth muscle cells and reduce the development of cardiovascular diseases.

This utility model belongs to the technical field of compression hemostasis devices, specifically relating to a dual-point positioning compression hemostasis device. It includes a fixing part, a first hemostasis part, and a second hemostasis part. The first hemostasis part includes a first positioning frame and a first pressing element; the first pressing element and the first positioning frame are detachably connected. The second hemostasis part includes a second positioning frame and a second pressing element; the second pressing element and the second positioning frame are detachably connected. Both ends of the fixing part are slidably connected to the first and second positioning frames, respectively. It also includes an adjustment part; both ends of the adjustment part are detachably connected to the first and second positioning frames, respectively. The first and second hemostasis parts provide precise compression hemostasis at skin puncture points and vascular puncture points, effectively preventing subcutaneous hematoma and fistula endothelial damage, thus extending the lifespan of the arteriovenous fistula. The states of the first and second hemostasis parts can be adjusted to regulate the pressure intensity, meeting the dual requirements of dual-point positioning and precise pressure control.

This invention provides an active polypeptide and its application in the preparation of drugs that promote the repair of endometrial damage, belonging to the field of biomedical technology. The sequence of the polypeptide is as follows: Acetyl-Gly-Phe-Phe-Tyr-Gly-Val-Arg-Lys-Lys-Pro. The active polypeptide of this invention is non-cytotoxic and non-reproductive toxic, and can promote the proliferation of endometrial epithelial cells, restore the number of endometrial glands in cases of intrauterine adhesions, reduce the proportion of fibrosis, and promote the thickening of thin endometrium. Its effects are superior to PDGF protein, and it has advantages such as high tissue compatibility, simple preparation, and significant improvement effects.

The application provides a directional thrombolytic pro-endothelialization composite small-caliber artificial blood vessel and a preparation method thereof. The method activates and chemically modifies the surface of an expanded polytetrafluoroethylene (ePTFE) artificial blood vessel through plasma treatment, introduces active carboxyl groups and covalently grafts a pro-endothelial adhesion polypeptide REDV; then, by using the strong adhesion of a polydopamine (PDA) coating, nano-hydrogel particles loaded with thrombolytic drugs t-PANPs are fixed on the inner surface of the blood vessel. The application actively recruits endothelial cells by the bottom layer of the REDV polypeptide, and at the same time, realizes on-demand and controlled release of t-PA for thrombolysis by the upper layer of the nano-hydrogel, thereby solving the problems of easy thrombosis and intimal hyperplasia of the small-caliber artificial blood vessel. The preparation process condition is mild, the performance is stable, the synergistic effect of antithrombosis and pro-endothelialization is realized, and the application has a good clinical application prospect.

In general, the present disclosure describes a computer-implemented method that can be used to detect at least one sign of endometriosis (e.g., a Douglas pouch (POD) closure), as well as a solution to the modality missing problem. Advantageously, the method of the present technology can accurately classify at least one sign of endometriosis using TVUS or MRI data, thereby indicating a diagnosis of endometriosis in a patient.

This invention provides a vascular diameter measuring device, comprising a catheter and a shape memory spring. The catheter has an outlet that connects the interior and exterior of the catheter. The shape memory spring comprises multiple coils of different diameters, arranged along the axial direction of the shape memory spring and connected end to end in sequence. The shape memory spring is housed inside the catheter in a deformed manner. When the shape memory spring is pushed out from the outlet of the catheter to the exterior, the deformed coils return to their original shape. This design is simple to operate and effectively reduces scratches to the vascular endothelium.

The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.

The utility model provides a kind of endometrial sampler, belong to medical instrument technical field, for solving the problem of sampler in prior art easy to damage uterus and sampling not complete, including sleeve, trachea, air bag, the trachea is movably sleeved in the sleeve, the sleeve with the trachea is detachably connected, the trachea is extended to outside and penetrates the sleeve, one end of the trachea is fixedly connected with the air bag, and the air bag outer wall circumference is provided with bristle in radial pattern.The utility model is easy to operate, more comprehensive, accurate sampling, while high safety, reduce the damage to uterus.

This invention relates to a self-sampling system for collecting menstrual blood, comprising a collection device; and a container containing a blood-stabilizing substance mixture for receiving the collected menstrual blood, and also relates to the use of said system for diagnosing gynecological diseases such as endometriosis.

The application discloses a kind of new aortic dissection tear twist degree measuring method, belong to clinical medical technical field, B type aortic dissection refers to the intima of descending aorta is torn, blood flow is propagated along the longitudinal direction of aorta through intimal break, and forms true cavity and false lumen.False lumen refers to the newly formed lumen after intimal tear.At present, there is lack of quantitative false lumen twist degree analysis index in domestic and foreign researches.Firstly, the CT angiography axial position sequence of patient when being diagnosed is acquired, and a space orthogonal rectangular coordinate system is established after being introduced into measurement software, the false lumen position and dissection longitudinal tear length are determined, the three-dimensional coordinates of target points are sequentially measured from the axial position image from the tear starting point to the end point, the three-dimensional coordinates of all measurement points are exported, and the false lumen twist degree related indexes are sequentially calculated.The above-mentioned patent has the following beneficial effects: by using the above-mentioned measurement scheme, the purpose of measuring the false lumen twist degree of B type aortic dissection can be achieved, and evaluation indexes are provided for further exploring the false lumen twist rule.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating atherosclerosis, its preparation method, and application. The traditional Chinese medicine composition for treating atherosclerosis consists of the following raw materials in parts by weight: 4-15 parts of prepared aconite root, 4-15 parts of ephedra, 20-40 parts of poria cocos, 10-20 parts of cudweed, 10-20 parts of pinellia ternata, 5-15 parts of alisma plantago-aquatica, 4-15 parts of rhubarb (processed with wine), and 10-20 parts of angelica dahurica. This traditional Chinese medicine composition for treating atherosclerosis can achieve comprehensive intervention on atherosclerosis through a dual-target mechanism of "metabolic regulation + anti-inflammatory effect." By reducing serum inflammatory response, improving lipid deposition in the aortic intima, and reducing plaque thickening, it has significant therapeutic effects and good safety in treating atherosclerosis-related tissue inflammatory damage, and has high application value and promising prospects for promotion.