315 results about "Tunica intima" patented technology

The invention belongs to the technical field of biological materials, and particularly discloses a blood vessel biological patch and preparation thereof, the blood vessel biological patch has the maximum tensile elongation of 20.1-35.1%, the elastic deformation rate of 15.1-29.4%, the value of the elastic deformation rate accounting for the maximum tensile elongation is 54-90%, and the bursting strength is 38-55N. The blood vessel biological patch provided by the invention can effectively reduce bleeding at the suture after carotid endarterectomy and prevent the problem of unstable performance of the biological patch.

The invention relates to the technical field of image recognition, in particular to an adhesion focus positioning method for an endometriosis rat model, which comprises the following steps of: firstly, adjusting a clustering distance according to color difference between saturation connected domains and a position inertial system, and clustering to obtain a connected domain cluster; due to the fact that the connected domain clusters contain the ectopic glands, the clusters need to be screened to obtain the ectopic glands, the gland probability of each connected domain cluster is obtained according to the characteristic that columnar epithelial cells are distributed on the inner walls of the ectopic glands, and the possibility that each connected domain cluster belongs to the ectopic glands is judged; due to the fact that the ectopic glands are distributed in a concentrated mode, the abnormal probability of the connected domain clusters is obtained through the aggregation of the connected domain clusters with the high gland probability, the possibility that the connected domain clusters belong to the abnormal ectopic glands is further judged, and the focus positioning accuracy of the endometriosis rat model is higher.

The invention provides an application of a composition containing cryopreserved prp in treatment of gynecological diseases. The invention also provides a reproduction promoting peptide which can obviously promote the proliferation and migration activity of human endometrial stromal cells, can reduce the apoptosis level of the cells, and has a better promoting effect. In addition, the cryopreserved prp is also prepared, after the cryopreserved prp is combined with the reproduction promoting peptide, the repair of the endometrial injury of the rat can be remarkably promoted, and a relatively good treatment effect is achieved.

A use of a GPR1 as a target in preparing an endometriosis-related diagnostic and / or therapeutic formulation, relating to the technical field of biomedicine. The present invention provides a use of a GPR1 target as a diagnostic marker in preparing a reagent or kit for diagnosing endometriosis. The endometriosis is selected from one of uterosacral ligament endometriosis, peritoneal endometriosis, rectovaginal endometriosis, deep infiltrating endometriosis, and ovarian endometriosis. The present invention discovers that the expression of the GPR1 is significantly increased in endometriosis tissues and cells, indicating that the GPR1 can be used as a diagnostic marker for endometriosis. It has been discovered in in-vitro and in-vivo models that GPR1 knockout significantly inhibits the abilities of hEM15A cells to proliferate, migrate, and invade and the growth of ectopic foci in animals, indicating that the GPR1 can be used as a new intervention target for clinically treating endometriosis.

The invention provides a self-adaptive intimal plaque reverse peeler. The self-adaptive intimal plaque reverse peeler is characterized by comprising a reverse peeler body and a cutting part, the reverse stripping device body is composed of a self-adaptive stripping ring and a push-pull rod; the self-adaptive stripping ring has a structure capable of stretching according to pressure, is arranged at the tail end of the push-pull rod, and has a groove-shaped structure with a C-shaped or U-shaped section; the cutting piece is composed of a cutting body and a traction piece. The cutting main body is arranged in the groove-shaped structure of the self-adaptive stripping ring, and the cutting action is completed in a ring diameter reducing mode along with lifting of the traction piece. The self-adaptive reverse peeling device can adjust the radial width in a self-adaptive manner along with blood vessels, so that plaques are completely peeled off.

The invention relates to the technical field of laparoscope image labeling, in particular to a laparoscope real-time recognition method for ovarian endometriosis cyst. The method comprises the following steps: firstly, analyzing the possibility that suspected cyst areas divided by a preset segmentation model have false boundaries in combination with the position and structural features of the false boundaries, and determining a boundary correction coefficient of each suspected cyst area in each frame of image; further dividing each suspected cyst area in each frame of image into a plurality of local areas, performing fine analysis on the suspected cyst areas in combination with instrument traction and breathing influence, evaluating the cyst confidence coefficient of each local area as a micro cyst, and finally comprehensively adjusting segmentation parameters of the segmentation model to obtain a micro cyst segmentation result. Therefore, the real cyst area is accurately segmented and marked, and the recognition effect of the ovarian endometriosis cyst focus is improved.

The present disclosure relates generally to the use of medical devices for the treatment of vascular conditions. In particular, the present disclosure provides devices and methods for using laser-induced pressure waves created within a sheath to disrupt intimal and medial calcium within the vasculature. The present disclosure also provides treatment mode selection systems that may be used with such devices and methods.

A device adapted to monitor the follicles and to assess the thickness of the endometrium of a subject, comprises: a) an elongated member having a tip that houses an ultrasound probe; b) a handle adapted to be held in the hand of a subject; and c) a mechanism suitable to angularly displace said handle relative to said elongated member.

The utility model relates to the technical field of medical instruments, in particular to a coronary arterial cardioplegic fluid perfusion device which comprises a shunt bag, a main perfusion tube is fixedly connected onto the shunt bag, an exhaust tube is fixedly connected onto the main perfusion tube, the main perfusion tube is communicated with the inside of the exhaust tube, a bacterial membrane connector is arranged at the front end of the exhaust tube, and the bacterial membrane connector is fixedly connected with the shunt bag. A bacterial membrane is fixedly connected into the bacterial membrane connector, a protective connector is movably connected to the front end of the bacterial membrane connector, a gathering opening is fixedly connected into the protective connector, a protective plate is arranged at the front end of the protective connector, and heating ring cloth is movably connected to the outside of the flow dividing bag. The device has the advantages that the exhaust pipe is horizontally arranged, the bacterial membrane connector and the protective connector are arranged at the front end of the exhaust pipe, dust and bacteria can be prevented from entering the shunting bag, the device is easy to operate, the risk of coronary intima injury can be effectively reduced, and during perfusion operation of the device, a left coronary artery and a right coronary artery can be subjected to synchronous perfusion and independent perfusion.

The invention discloses application of GPR1 as a target spot in preparation of endometriosis related diagnosis and / or treatment preparations, and belongs to the technical field of biological medicines. The invention provides application of a GPR1 target spot serving as a diagnostic marker in preparation of a reagent or a kit for diagnosing endometriosis. The endometriosis is selected from one of a uterus-sacral ligament type endometriosis, a peritoneal type endometriosis, a rectum-vagina type endometriosis, a deep infiltration type endometriosis and an ovarian type endometriosis. The invention discovers that the expression of GPR1 in endometriosis tissues and cells is obviously increased, which prompts that GPR1 can be used as a diagnostic marker of endometriosis. In-vitro and in-vivo models find that the knockout of GPR1 significantly inhibits the proliferation, migration and invasion ability of hEM15A cells and the growth of ectopic lesions in animals, indicating that GPR1 can be used as a new intervention target for clinical treatment of endometriosis.

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in communication with distal balloon portion and medial balloon portion for expansion of said balloon portions.

The present invention proposes a multi-branch stent for aortic dissection distal aneurysm zoning, belonging to the field of medical device technology. It includes a main covered stent, which is composed of a covering and a main stent. The main covered stent is sequentially arranged from one end to the other end as an upper half, a waist transition section and a lower half; the upper and lower parts of the upper half in the vertical direction are respectively a soft zone and a hard zone; the upper and lower parts of the lower half in the vertical direction are respectively a hard zone and a soft zone; the upper and lower parts are respectively provided with two embedded branch stents; the embedded branch stent in the upper half is used to reconstruct the celiac trunk and the superior mesenteric artery, and the embedded branch stent in the lower half is used to reconstruct the bilateral renal arteries. The present invention increases the adaptability of the anchoring areas at both ends of the main covered stent to the blood vessels, prevents the rupture of the inner membrane sheet of the distal rupture, improves the adhesion of the main covered stent to the tube wall, reduces the incidence of type I internal leakage, reduces the incidence of new stent-induced ruptures after surgery, and can reconstruct visceral arteries at the same time.

The invention belongs to the technical field of medical apparatus and instruments, and particularly relates to a gynecological endometrium sampling device which comprises a liquid negative pressure extraction mechanism, a liquid collection and storage mechanism and a self-adaptive uterus sampling mechanism, the liquid collection and storage mechanism is fixedly arranged on the liquid negative pressure extraction mechanism, and the self-adaptive uterus sampling mechanism is fixedly arranged on the liquid negative pressure extraction mechanism. The self-adaptive uterus sampling mechanism is arranged in the liquid negative pressure extraction mechanism and is in sliding connection with the liquid negative pressure extraction mechanism; liquid in the uterus can be sucked and removed firstly, then comprehensive sampling is conducted, a sampled sample is protected and stored, the sample quality is effectively improved, and the sampling failure problem is avoided.

The invention relates to the technical field of biology, and particularly discloses a construction method and application of an endometrial epithelium organ fibrosis model. According to the method, human endometrial epithelial cells are extracted, and an endometrial epithelial organ is established by adopting a Matrigel three-dimensional culture system. Afterwards, the organoid is induced to form endometrial phenotypes in different physiological cycles through hormone stimulation, and a ferroptosis inducer FIN56 is added in the culture process to induce fibrosis. The expression of GPX4, Fibronectin and p-Smad2 / 3 is detected through Western blot and immunofluorescence, and the successful construction of the fibrosis model is verified. The invention provides an in-vitro model capable of simulating endometrial fibrosis pathological characteristics of a patient with PCOS (polycystic ovarian syndrome), the in-vitro model can be used for mechanism research and drug screening of PCOS-related endometrial lesions, and a new research tool and an intervention strategy are provided for treatment of PCOS endometrial fibrosis.

The present disclosure provides systems and methods for Al model(s) that are trained to identify characteristics associated with lesions within a blood vessel and provide a suggested procedure associated with the lesion. The Al model may receive, as input, intravascular and / or extraluminal image data associated with the blood vessel and provide, as output, characteristics, e.g., characterizations, associated with the blood vessel. The characterizations may include, for example, form or tissue nature (e.g., microcalcification, punctate, fragment, sheet, nodular, or otherwise), location within the vessel (e.g., intimal, superficial, medial, deep, etc.), size (e.g., length, depth, thickness, etc.), severity, and / or the like. The characterizations may be used as input to the same and / or a different model for providing a suggested procedure associated with the lesion. The suggested procedure may include, for example, orbital atherectomy, intravascular lithotripsy, rotational atherectomy, cutting and / or scoring balloons, and / or the like.

The invention belongs to the technical field of intelligent medical images, and particularly relates to a method and device for determining the age of a blood vessel, electronic equipment and a readable medium. The method comprises the following steps: acquiring a carotid intima-media membrane image; based on the carotid intima-media image, image processing is carried out on the carotid intima-media image to obtain carotid image features and intima-media thickness information, and the carotid image features are used for representing echo texture features of the carotid intima-media image; the intima-media thickness information is used for representing the thickness between the intima and the media of the carotid artery in the carotid intima-media image; based on the carotid artery image features and the intima-media thickness information, obtaining a corresponding blood vessel age calculation model; and inputting the carotid artery image features and / or the intima-media thickness information into the vascular age calculation model to obtain the vascular age of the carotid artery in the carotid artery intima-media image. The method is used for improving the accuracy of determining the blood vessel age.

The invention relates to a lightweight yolov8-based endometritis classification and identification method and system, and the method comprises the steps: determining classified target historical hysteroscope image data, and enabling classification labels to comprise a normal classification group indicating normal endometrium and a lesion classification group indicating the existence of endometritis; dividing the target historical hysteroscope image data according to a preset distribution proportion to obtain training data and verification data; training data and verification data are input into a yolov8 classification model, in the training process, model lightweight processing is carried out based on weight importance pruning, quantification and knowledge distillation technologies, and feature weighting and selection based on an attention mechanism are carried out on target area features detected by yolov8 and related to endometrium and pre-acquired auxiliary modal features, so that the model weight is reduced; key feature information is extracted; and inputting real-time hysteroscope image data into the trained yov8 classification model to obtain an endometrial inflammation classification result for auxiliary diagnosis.

The invention discloses a construction method of a novel ovarian endometriosis mouse model. Longitudinally cutting the uterus tissue of the donor mouse into small pieces; then putting the small uterus blocks into a collagenase solution for incubation; then removing collagenase from the small uterus blocks; attaching the small uterus block to the notch of the female mouse of which the envelope on the ovary surface is cut, so that the small uterus block covers the exposed ovary surface, pushing back into the abdominal cavity as soon as possible, nailing the skin and muscles by using a suturing nail, disinfecting and putting back into the mouse cage; after 24 hours of fasting, water can be freely drunk; and conventionally feeding after 24 hours. The method does not need preoperative / postoperative estradiol management, has the advantages of simplicity in operation, time saving, good effect, high molding success rate (about 90%) and the like, and is worthy of further popularization. The constructed ovarian endometriosis mouse model can evaluate the ovarian function condition and the influence of infertility, and overcomes the defect that the existing endometriosis mouse model lacks special ovarian types.

The invention relates to a pharmaceutical composition for treating uterine adhesion and application thereof. The kidney reinforcing and miscarriage preventing pills are used for improving endometrial blood perfusion and increasing the endometrial thickness, the kidney reinforcing and miscarriage preventing pills, aspirin and estrogen play a synergistic treatment role, the postoperative re-adhesion rate is remarkably reduced through combined treatment, and the fertility prognosis of a patient is improved; and the molecular mechanism of a TGF-beta1 pathway and EMT is deeply researched, and by inhibiting excessive activation of the TGF-beta1 signaling pathway, reducing endometrial fibrosis, regulating an epithelial-mesenchymal transition (EMT) process and promoting regeneration of endometrial epithelial cells, endometrial repair is further promoted, multi-target treatment is realized, and the treatment effect is remarkable. A brand-new and efficient treatment scheme is provided for treatment of intrauterine adhesion, an individualized treatment scheme can be formulated according to the specific conditions of patients, the treatment accuracy and effectiveness are improved, and important clinical significance and application value are achieved.

The invention discloses application of circSATB1 in preparation of a medicine for improving sheep fecundity, and belongs to the technical field of biological medicine. The nucleotide sequence of the circSATB1 is as shown in SEQ ID NO. 1. The circRNA expression profile of the sheep seminal plasma extracellular vesicles is analyzed for the first time, the expression quantity of circSATB1 in the seminal plasma extracellular vesicles is high, proliferation and migration of endometrial epithelial cells can be remarkably promoted through overexpression of circSATB1, and apoptosis of the endometrial epithelial cells is remarkably inhibited. If circSATB1 is interfered, proliferation and migration of endometrial epithelial cells can be extremely remarkably inhibited, and apoptosis of the endometrial epithelial cells can be extremely remarkably promoted. All the results prove that circSATB1 has important significance in endometrial receptivity formation, and a new thought is provided for improving the implantation rate of female livestock embryos.

The invention discloses a medical anti-mucosa coated silicone rubber stent for preventing adhesion and drainage after a uterine cavity operation, and belongs to the technical field of medical apparatuses and instruments. The invention relates to an anti-adhesion composite stent which is composed of a triangular silicone rubber stent frame (2) with a mould pressing flash film (1), a coated medical anti-adhesion film (3), an assembly stay wire (7) and a connecting silicone rubber drainage tube (8). The device is used for preventing endometrial adhesion and draining after the uterine cavity operation. The configuration and the flexible mechanical property of the anti-adhesion composite stent (4) are matched with the anatomical form of the uterine cavity, and a perfect physical barrier isolation effect is achieved. The surface of the medical anti-adhesion membrane (3) has good affinity with the inner membrane of an operative wound, so that the repair and regeneration of the inner membrane of the wound can be promoted. A surgeon can longitudinally lengthen and transversely fold the anti-adhesion composite stent (4) into a slender strip shape by means of the soft plastic push rod (6) and the pull wire (7), the anti-adhesion composite stent (4) is gently pushed into the uterine cavity, and the anti-adhesion composite stent (4) automatically retracts to restore a triangular structure after being released and is smoothly spread in the uterine cavity. And after treatment, the uterine cavity is gently pulled out.

The utility model discloses a balloon and an intracranial artery dilatation system. The balloon comprises a balloon body, a plurality of micropores which are formed in the balloon wall of the balloon body and communicated with an inner cavity of the balloon body, and annular protruding parts located on the two sides of the balloon body in the axial direction. After the balloon is expanded, the annular protruding parts make contact with the inner wall of the artery, so that a gap is formed between the balloon wall between the two annular protruding parts and the inner wall of the artery, and medicine flowing out of the micropores enters the gap at first. When the balloon is used, the medicine flowing out of the micropores of the balloon wall of the balloon body enters the gap firstly and does not directly act on the inner wall of the artery, so that the impact of the medicine on the inner wall of the artery can be remarkably reduced, the damage to the artery can be remarkably reduced, and the probability of injury of an inner membrane, aneurysm and acute bleeding can be remarkably reduced.

A menstrual blood-derived endometrial cell collection device is provided. [Solution] The device comprises a central hand-held hollow tube 1 and a curette function part 2. Inside are an inner limiting hollow tube and an annular stopper ring with an elastic stopper plate. A rotating knob 6 is attached to the end of the central hand-held hollow tube by a screw connection, and the inclined annular pressure ring of the rotating knob acts on the outside of the elastic stopper plate. The hollow shaft of the curette function part passes through the rotating knob and extends into the inner limiting hollow tube and is positioned by the elastic stopper plate. A friction groove is formed on the outer edge of the rotating knob. This device allows for quick replacement of the curette function part, flexible adjustment of the protrusion length, and excellent portability.

The invention provides application of injectable bioactive hydrogel in treatment of recurrent abortion, and relates to the technical field of biomedicine, and the technical key points are as follows: aldehydic hyaluronic acid and chitosan are connected in parallel, the injectable bioactive hydrogel is developed, and the hydrogel is loaded with LIF, VEGF, IL-11 and valproic acid to enhance regeneration activity. According to the application, the effect is evaluated in vitro through a specific verification experiment. Results show that the hydrogel prepared by the application shows rapid gelation, good biocompatibility and factor loading capacity, and enhances the proliferation of human endometrial stromal cells and the vascularization capacity of human umbilical vein endothelial cells. In macrophages, the expression of a proinflammatory cytokine is down-regulated, and the expression of an anti-inflammatory cytokine IL-10 is up-regulated. In conclusion, the HA-CHO / chitosan hydrogel in the application supports endometrial regeneration by synergistically promoting proliferation, angiogenesis, immune regulation and receptivity.

The utility model discloses a drainage hole with a function of preventing blood vessels from adhering to the wall. The drainage hole comprises a drainage hole body, an anti-injury block, a supporting ring, a drainage ditch and an arc-shaped cannula adhering face. A gap between every two adjacent damage blocks is a drainage ditch; each anti-damage block consists of an anti-damage table, an access slope, an access arc, an anti-damage arc I and an anti-damage arc II, wherein the anti-damage table is positioned at the upper part of the anti-damage block; the access slope is located outside the anti-damage block; the access arc is in transition connection between the access slope and the anti-damage table; the anti-damage arc I is positioned on the inner side of the anti-damage block; the anti-damage arcs II are located on the two sides of the anti-damage block. According to the utility model, the drainage holes can be effectively prevented from being blocked by endangium, so that the following problems are avoided: the treatment effect is reduced or even interrupted due to sudden drop of drainage quantity, and the life of a patient is endangered; due to the fact that drainage holes are blocked by endangium, the endangium is injured due to the high pressure difference between intravascular equipment and extracorporeal equipment; endovascular injury generates thrombus which endangers the life of a patient.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

A device for intravascular use for treating an endovascular membrane is provided. The device includes a catheter adapted to form a plurality of nested hoops rotatable relative to each other in a deployed position. The plurality of hoops may include an inner hoop having a smaller diameter than an outer hoop, each of the hoops connected to a corresponding tube. One or more motors may be used to rotate the hoops relative to each other, including in a counter-rotating manner. Related methods are also disclosed.

The application provides an aortic dissection rupture sealing device, which comprises a body having a hollow flow channel extending along the axial direction of the body, the hollow flow channel penetrating the rupture for conducting the true lumen of the aorta and the branch blood vessel, and the body being used for connecting a stent located in the branch blood vessel; and an anchoring part arranged on the body and surrounding the hollow flow channel, and anchored to the surrounding intima at the rupture, so as to prevent the fluid from conducting between the true lumen and the false lumen formed at the rupture. By using the above scheme, the rupture sealing effect can be improved, the continuous expansion of the false lumen caused by the incomplete rupture sealing and the residual liquid leakage can be avoided, and the blood supply stability of the branch blood vessel can be ensured, so that the blood supply demand of the internal organs, the spinal cord and the like supplied by the branch blood vessel can be met.

The invention relates to a flexible conductive intravenous stent based on functional electrical stimulation. The invention belongs to the fields of biomedical engineering and the like. The PCL-Gr extravascular stent is prepared by utilizing an electrostatic spinning technology, and the PCL-Gr extravascular stent wraps the periphery of the transplanted vein to provide necessary mechanical support for the transplanted vein so as to maintain the structural stability of the transplanted vein, so that the risk of restenosis caused by hemodynamic change is reduced. And meanwhile, functional electrical stimulation is accurately applied to transplanted veins by utilizing conductivity, so that double mechanisms of promoting endothelialization and inhibiting smooth muscle cell proliferation are achieved, and the risk of intimal hyperplasia is effectively reduced.

The application provides a pulmonary artery tissue-derived cell, an organoid and a construction method and application thereof. The pulmonary artery intimal stripping tissue organoid structure obtained by the preparation method is clear, has consistent cell types as the source tissue, is close to the original tissue, is convenient for researchers to operate, and thus has good practical application value.