75 results about "Arterial wall" patented technology

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

This invention, which offers the advantage of an automatic repetitive blood pressure measurement that minimizes discomfort for the subject while continuously measuring blood pressure regardless of the subject's movement, thereby enhancing the reliability of the measurement results, which leads to the development of an automatic repetitive blood pressure measurement device and method for a smart blood pressure monitor, relates to blood pressure measurement technology, involving periodically repeating the inflation and deflation of a cuff a set number of times upon receiving a single operation signal input. The method includes the steps of detecting arterial wall vibrations when the cuff pressure is between the systolic and diastolic pressures of the artery during cuff inflation and deflation, recognizing the point where maximum vibration is detected as the systolic blood pressure based on the detection results, recognizing the diastolic blood pressure if the vibration decrease exceeds a threshold, and providing measurement results sequentially, including the recognized systolic and diastolic blood pressure values during the repeated inflation and deflation of the cuff a set number of times.

The invention discloses a minimally invasive coronary artery bypass blood vessel proximal anastomosis instrument kit and an anastomosis control system. The device comprises a hole puncher, a stitching instrument and an anvil section clamping device, the puncher comprises a puncher body and an anvil section, the puncher body comprises an inner shaft, a cutting pipe and an outer pipe which are sequentially arranged from inside to outside, and the end of the inner shaft is in threaded connection with the anvil section; the stitching instrument comprises a main cylinder, an eccentric rotating shaft and a needle storage bin, and the eccentric rotating shaft is in sliding and rotating connection with the main cylinder; the end part of the eccentric rotating shaft is connected with the needle storage bin; a needle inserting position for inserting a straight sewing needle with a thread is formed in the needle storage bin, and an inserting opening of the needle inserting position faces the main cylinder body; a connecting structure used for being in threaded connection with the anvil section is arranged on the side, away from the main cylinder, of the needle storage bin. The straight suture needle with the thread is hidden in the needle storage bin and enters the aortic cavity together with the stitching instrument, then the straight suture needle with the thread is separated from the main cylinder by rotating the needle storage bin, then the straight suture needle with the thread penetrates through the aortic wall from inside to outside in the aortic cavity, and one-needle stitching is completed.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

Described are methods and devices for dilating tubular anatomical structures. The devices and methods may be useful for extracting blood clots in mammalian arteries by concentrically irradiating the inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. The dilation occurs as a result of the photophysical production and release of nitric oxide from cells lining the arterial wall when the UV laser light is projected as a ring beam onto the inner arterial wall.

In some implementations, the device may include a plurality of ultrasound sensors configured to capture tomographical information of a physiological structure. In addition, the device may include an ultrasound coupling medium on each of the plurality of ultrasound sensors. The device may include a processing device configured to: apply beamforming techniques to the ultrasound sensors; capture, using the plurality of ultrasound sensors, bodily data of overlapping volumes of the physiological structure; process the bodily data to generate a vessel location model; and locate a blood vessel from the generated vessel location model.

A system for accessing one or more artery in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, the proximal end of the shaft including a first connection portion, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a curve of the sheath lumen, a resilient access-extension tube having an extension lumen extending therethrough, the extension lumen having a distal end and a proximal end, the distal end of the extension lumen configured to hydraulically couple to the sheath lumen at the first connection portion, and sealable opening carried by the access-extension tube and spaced from the distal end of the extension lumen, the sealable opening configured to allow insertion of an elongate medical device into the extension lumen for advancement through the extension lumen when the access-extension tube is coupled to the access sheath, for passage through the extension tube and the sheath lumen, and into the superficial temporal artery of the subject.

The application provides an imaging method and device for an arterial wall structure, a soliton light source signal is obtained by preprocessing a laser signal, the soliton light source signal is emitted to a microscopic imaging system, a first target position of a target object is scanned and imaged by the microscopic imaging system, and a third harmonic image and a three-photon fluorescence image are obtained. According to the technical scheme, the soliton light source signal of a specific wavelength is obtained by preprocessing the laser signal in advance, the soliton light source signal has better adaptability to a marker (stronger excitation characteristic), the imaging quality of the third harmonic image and the three-photon fluorescence image after imaging of the microscopic imaging system is improved, direct visualization and easy resolution of different layers of the arterial wall structure are achieved, and the microscopic imaging system configured with a gallium arsenide photomultiplier tube and a gallium arsenic phosphor photomultiplier tube is used, two-channel acquisition is adopted to realize twice scanning and imaging of the first target position of the target object, and the number of obtained image details is ensured.

A system for accessing one or more arteries in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a substantially U-shape or J- shape of the sheath lumen, and a sealable opening carried by the proximal end of the shaft and opening into the shaft lumen, the sealable opening configured to allow passage of the elongate medical device through the sheath lumen, and into the superficial temporal artery of the subject.

The invention provides an arterial flow limiter. The arterial flow limiter comprises a fixing support used for anchoring the flow limiter to an artery; the flow adjusting support is used for adjusting blood flow; the connecting part is used for connecting the fixed bracket and the flow adjusting bracket; the fixing support allows blood to pass through holes of the fixing support, and the mesh density of the fixing support is smaller than that of the flow adjusting support, so that after the blood flows through the fixing support, most of the blood flows through a gap between the flow adjusting support and an artery wall; the expansion degree of the flow adjusting support can be adjusted, the outer surface of the flow adjusting support is of a streamline structure, the curvature radius Rc of the outer contour is matched with the diameter D of the artery, and Rc / D = 0.25 is met, so that the wall surface shearing force of blood flow to the artery is stabilized within a certain range, and turbulent flow is prevented from being formed.

An artery can be occluded by implanting an occlusion implant within a subintimal space within a wall of the artery. As an example, a catheter having a side port just proximal of an inflatable balloon disposed near a distal end of the catheter can be advanced through the artery to a site at which an occlusion is desired. The inflatable balloon can be inflated and a guidewire can be advanced through a lumen of the catheter, out of the side port and into a subintimal space of the artery, with the inflated inflatable balloon guiding the guidewire towards the artery wall. An occlusion implant can be advanced over the guidewire into the subintimal space and the guidewire can be withdrawn, leaving the occlusion implant positioned within the subintimal space.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

The present invention, in some embodiments thereof, relates to methods and / or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.

The present invention discloses a minimally invasive coronary artery bypass grafting proximal anastomosis instrument kit and anastomosis control system. It includes a puncher, a suturer and an anvil segment holder; the puncher includes a puncher body and an anvil segment, the puncher body includes an inner shaft, a cutting tube and an outer tube arranged in sequence from the inside to the outside, and the end of the inner shaft is threadedly connected with the anvil segment; the suturer includes a main cylinder, an eccentric rotating shaft and a needle storage bin, the eccentric rotating shaft is slidably connected and rotatably connected to the main cylinder; the end of the eccentric rotating shaft is connected to the needle storage bin; a needle insertion position for inserting a straight threaded suture needle is provided in the needle storage bin, and the socket of the needle insertion position faces the main cylinder; a connection structure for threading the anvil segment is provided on the side of the needle storage bin away from the main cylinder. The straight threaded suture needle of the present invention is hidden in the needle storage bin, and enters the aortic cavity together with the suturer, and then the needle storage bin is separated from the main cylinder by rotating, and then the straight threaded suture needle passes through the aortic wall from the inside to the outside in the aortic cavity to complete a needle suture.

An apparatus may include a platen, a light source system, and an ultrasound receiver system. The platen may be configured to separate one or more received arterial ultrasound waves generated by blood in the artery, by the wall of the artery, or a combination thereof from one or more other types of received ultrasound waves. The platen may have an outer surface having an acoustic impedance configured to approach an acoustic impedance of human skin. An outer surface of the platen may be configured to conform to a surface of human skin. The apparatus may include a noise reduction system. The light source system may include at least one multi-junction laser diode. The apparatus may include a mirror layer residing between the ultrasound receiver system and the platen.

The present disclosure relates to ultrasonic catheters including vibration wires that are positionable in a retracted position and an extended position, and their methods of use. In operation, catheters according to the present disclosure are operable in an occlusion crossing mode, in which the catheter emits ultrasonic energy with the vibration wires in the retracted position and in an atherectomy mode, in which the catheter emits ultrasonic energy with the vibration wires in the extended position, causing the vibration wires to oscillate. The vibration wires may directly or indirectly engage plaque within an artery, causing the plaque to break free from the artery wall. The oscillation of the vibration wires may be less abrasive than conventional cutting elements used in atherectomy procedures, such that catheters according to the present disclosure may cause less trauma to artery walls as compared to conventional atherectomy devices.

The present system is directed in various embodiments to rotational atherectomy systems and methods generally. More specifically, a method for methodically softening and otherwise disrupting calcification located within atherosclerotic plaque, lesion or occlusion and / or within the wall of a biological conduit or lumen. The softening and / or disruption of the calcification in the walls of the exemplary artery is accomplished in conjunction with abrading removal of any occlusion located on the interior surface of the exemplary artery and, therefore, located within the artery's lumen. This result is achieved by use of at least one eccentric head that, during high-speed rotation within the exemplary lumen, has been found to produce a combination of a low-frequency orbital motion comprising a force that is exerted against the lumen wall, with concomitant deflection of same, and / or a high-frequency pulsatile frequency, also with concomitant exertion of force against the lumen wall and deflection of same.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and / or shearing of matter (i.e. thrombus) from a wall of the body lumen (i.e. a vein or an artery). The radially expansible member has a proximal end and a distal end and is adjustable between a contracted orientation and an expanded orientation. The elongated control member comprising a proximal arm connected at or adjacent to the proximal end of the radially expansible member and a distal arm connected at or adjacent to the distal end of the radially expansible member such that movement of one arm relative to the other arm effects adjustment of the diameter or radial strength of the radially expansible member. The device comprises a control mechanism operatively connected to both arms and adapted to provide resistance to the movement of one arm relative to the other. The control mechanism may be a biasing means, a brake means, or both.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

To provide agents for labeling and locating renal nerve.SOLUTION: A provided agent comprises human neuron or nerve-targeting molecule to be used by a method comprising: (a) contacting the renal nerve in the renal arterial wall with an agent, thereby labeling the renal nerve in the renal artery wall; and (b) illuminating the cargo through the renal artery wall in the kidney; receiving fluorescent light from the cargo; and using the received fluorescent light to determine the position of renal nerve in the renal artery wall during operation of a subject; and (c) using the position of the renal nerve in the renal artery wall for irradiating or guiding ablation of the renal nerve in the renal artery wall.SELECTED DRAWING: Figure 1

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

The invention relates to a blood pressure monitoring method and system based on a wearable ultrasonic transducer, and the method comprises the following steps: obtaining an ultrasonic continuous image of a to-be-monitored artery through the ultrasonic transducer, and obtaining the continuous position change information of an artery wall; obtaining continuous change information of the artery diameter along with time according to the continuous position change information of the artery wall; according to the artery diameter-blood pressure relation, continuous blood pressure data are obtained in combination with continuous change information of the artery diameter along with time; wherein the establishment of the artery diameter-blood pressure relationship comprises the following steps: selecting a proper superficial limb artery as a measurement area, and determining a calibration blood vessel; the blood vessel calibration information is obtained through a sphygmomanometer and an ultrasonic transducer; the ultrasonic echo time difference between the anterior artery wall and the posterior artery wall is obtained through the ultrasonic transducer, and the diameter of the artery is obtained; and fitting the calibration information and the artery diameter to obtain an artery diameter-blood pressure relationship. Compared with the prior art, real-time continuous monitoring of the superficial arterial blood pressure of the human body is achieved.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

In some implementations, the device may include a plurality of ultrasound sensors configured to capture tomographical information of a physiological structure. In addition, the device may include an ultrasound coupling medium on each of the plurality of ultrasound sensors. The device may include a processing device configured to: apply beamforming techniques to the ultrasound sensors; capture, using the plurality of ultrasound sensors, bodily data of overlapping volumes of the physiological structure; process the bodily data to generate a vessel location model; and locate a blood vessel from the generated vessel location model.

Systems having energy delivering thermocouple assemblies for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral / helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

A method for detecting the presence of an atheroma in an artery of interest using an ultrasound apparatus can include performing a first procedure on a first day. The first procedure can include detecting one or more blood vessels in a target region of a patient's body. The procedure can include identifying, from the one or more blood vessels, an artery of interest; automatically detecting spatial boundaries of constituent layers of an arterial wall of the artery of interest and calculating, via a processor of the ultrasound apparatus, a cross-sectional intima-media area (IMA) of the artery of interest at a first location along a length of the artery of interest. The procedure can include automatically calculating, via the processor of the ultrasound apparatus, IMA of the artery of interest at a second or more locations along the length of the artery of interest. In some embodiments, the procedure includes automatically calculating, via the processor and based at least in part on the calculations of the IMAs of the artery of interest at the first location and at the second or more locations, an intima-media volume (IMV), arterial volume, and luminal volume of the artery of interest over a predetermined length of the artery of interest.