54 results about "Arterial wall" patented technology

This invention, which offers the advantage of an automatic repetitive blood pressure measurement that minimizes discomfort for the subject while continuously measuring blood pressure regardless of the subject's movement, thereby enhancing the reliability of the measurement results, which leads to the development of an automatic repetitive blood pressure measurement device and method for a smart blood pressure monitor, relates to blood pressure measurement technology, involving periodically repeating the inflation and deflation of a cuff a set number of times upon receiving a single operation signal input. The method includes the steps of detecting arterial wall vibrations when the cuff pressure is between the systolic and diastolic pressures of the artery during cuff inflation and deflation, recognizing the point where maximum vibration is detected as the systolic blood pressure based on the detection results, recognizing the diastolic blood pressure if the vibration decrease exceeds a threshold, and providing measurement results sequentially, including the recognized systolic and diastolic blood pressure values during the repeated inflation and deflation of the cuff a set number of times.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

A system for accessing one or more artery in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, the proximal end of the shaft including a first connection portion, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a curve of the sheath lumen, a resilient access-extension tube having an extension lumen extending therethrough, the extension lumen having a distal end and a proximal end, the distal end of the extension lumen configured to hydraulically couple to the sheath lumen at the first connection portion, and sealable opening carried by the access-extension tube and spaced from the distal end of the extension lumen, the sealable opening configured to allow insertion of an elongate medical device into the extension lumen for advancement through the extension lumen when the access-extension tube is coupled to the access sheath, for passage through the extension tube and the sheath lumen, and into the superficial temporal artery of the subject.

The application provides an imaging method and device for an arterial wall structure, a soliton light source signal is obtained by preprocessing a laser signal, the soliton light source signal is emitted to a microscopic imaging system, a first target position of a target object is scanned and imaged by the microscopic imaging system, and a third harmonic image and a three-photon fluorescence image are obtained. According to the technical scheme, the soliton light source signal of a specific wavelength is obtained by preprocessing the laser signal in advance, the soliton light source signal has better adaptability to a marker (stronger excitation characteristic), the imaging quality of the third harmonic image and the three-photon fluorescence image after imaging of the microscopic imaging system is improved, direct visualization and easy resolution of different layers of the arterial wall structure are achieved, and the microscopic imaging system configured with a gallium arsenide photomultiplier tube and a gallium arsenic phosphor photomultiplier tube is used, two-channel acquisition is adopted to realize twice scanning and imaging of the first target position of the target object, and the number of obtained image details is ensured.

A system for accessing one or more arteries in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a substantially U-shape or J- shape of the sheath lumen, and a sealable opening carried by the proximal end of the shaft and opening into the shaft lumen, the sealable opening configured to allow passage of the elongate medical device through the sheath lumen, and into the superficial temporal artery of the subject.

The invention provides an arterial flow limiter. The arterial flow limiter comprises a fixing support used for anchoring the flow limiter to an artery; the flow adjusting support is used for adjusting blood flow; the connecting part is used for connecting the fixed bracket and the flow adjusting bracket; the fixing support allows blood to pass through holes of the fixing support, and the mesh density of the fixing support is smaller than that of the flow adjusting support, so that after the blood flows through the fixing support, most of the blood flows through a gap between the flow adjusting support and an artery wall; the expansion degree of the flow adjusting support can be adjusted, the outer surface of the flow adjusting support is of a streamline structure, the curvature radius Rc of the outer contour is matched with the diameter D of the artery, and Rc / D = 0.25 is met, so that the wall surface shearing force of blood flow to the artery is stabilized within a certain range, and turbulent flow is prevented from being formed.

An artery can be occluded by implanting an occlusion implant within a subintimal space within a wall of the artery. As an example, a catheter having a side port just proximal of an inflatable balloon disposed near a distal end of the catheter can be advanced through the artery to a site at which an occlusion is desired. The inflatable balloon can be inflated and a guidewire can be advanced through a lumen of the catheter, out of the side port and into a subintimal space of the artery, with the inflated inflatable balloon guiding the guidewire towards the artery wall. An occlusion implant can be advanced over the guidewire into the subintimal space and the guidewire can be withdrawn, leaving the occlusion implant positioned within the subintimal space.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

An apparatus may include a platen, a light source system, and an ultrasound receiver system. The platen may be configured to separate one or more received arterial ultrasound waves generated by blood in the artery, by the wall of the artery, or a combination thereof from one or more other types of received ultrasound waves. The platen may have an outer surface having an acoustic impedance configured to approach an acoustic impedance of human skin. An outer surface of the platen may be configured to conform to a surface of human skin. The apparatus may include a noise reduction system. The light source system may include at least one multi-junction laser diode. The apparatus may include a mirror layer residing between the ultrasound receiver system and the platen.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and / or shearing of matter (i.e. thrombus) from a wall of the body lumen (i.e. a vein or an artery). The radially expansible member has a proximal end and a distal end and is adjustable between a contracted orientation and an expanded orientation. The elongated control member comprising a proximal arm connected at or adjacent to the proximal end of the radially expansible member and a distal arm connected at or adjacent to the distal end of the radially expansible member such that movement of one arm relative to the other arm effects adjustment of the diameter or radial strength of the radially expansible member. The device comprises a control mechanism operatively connected to both arms and adapted to provide resistance to the movement of one arm relative to the other. The control mechanism may be a biasing means, a brake means, or both.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

To provide agents for labeling and locating renal nerve.SOLUTION: A provided agent comprises human neuron or nerve-targeting molecule to be used by a method comprising: (a) contacting the renal nerve in the renal arterial wall with an agent, thereby labeling the renal nerve in the renal artery wall; and (b) illuminating the cargo through the renal artery wall in the kidney; receiving fluorescent light from the cargo; and using the received fluorescent light to determine the position of renal nerve in the renal artery wall during operation of a subject; and (c) using the position of the renal nerve in the renal artery wall for irradiating or guiding ablation of the renal nerve in the renal artery wall.SELECTED DRAWING: Figure 1

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

Systems having energy delivering thermocouple assemblies for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral / helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

A method for detecting the presence of an atheroma in an artery of interest using an ultrasound apparatus can include performing a first procedure on a first day. The first procedure can include detecting one or more blood vessels in a target region of a patient's body. The procedure can include identifying, from the one or more blood vessels, an artery of interest; automatically detecting spatial boundaries of constituent layers of an arterial wall of the artery of interest and calculating, via a processor of the ultrasound apparatus, a cross-sectional intima-media area (IMA) of the artery of interest at a first location along a length of the artery of interest. The procedure can include automatically calculating, via the processor of the ultrasound apparatus, IMA of the artery of interest at a second or more locations along the length of the artery of interest. In some embodiments, the procedure includes automatically calculating, via the processor and based at least in part on the calculations of the IMAs of the artery of interest at the first location and at the second or more locations, an intima-media volume (IMV), arterial volume, and luminal volume of the artery of interest over a predetermined length of the artery of interest.

This invention discloses a pulse-release balloon dilation pump and method for intracranial arterial stenosis. Addressing the mechanical mechanism of thin intracranial arterial walls and irregular plaques leading to axial stress accumulation and subsequent complications such as dissection and detachment, this invention adds a pulse-release control unit to a conventional pressure pump. Its core physical principle is as follows: When the balloon dilates at an irregular plaque, the intramural strain energy density distribution is uneven. Static friction constraint keeps the system in a high-energy metastable state, and the accumulated elastic potential energy ΔU continuously increases with expansion. The constraint factor λ is defined as F_required / f_max; when λ>1, the balance is unstable, and energy suddenly bursts. This invention uses periodic short-term pressure release to instantaneously decrease the contact pressure, reduce the static friction limit, and briefly raise λ to >1, actively triggering micro-slippage, releasing a small portion of the accumulated energy each time, achieving segmented and gentle energy release. Pulse parameters (amplitude, frequency, etc.) can be flexibly adjusted according to actual clinical conditions. The pulse mode offers flexible and diverse usage options. Operators can initiate it synchronously in the early stages of dilation, when risk signs appear, intervene as needed during pressure application, or combine multiple methods, allowing the operator to independently determine the operational procedure. Based on thin-film mechanics, tribology, and viscoelasticity theories, this invention is simple to operate, does not alter the clinical procedure, and effectively reduces the risk of complications during intracranial artery stenosis balloon angioplasty.

A method of treating an arterial condition may include receiving image data of a patient from a medical diagnostic tool, deriving measurement data from the received image data, determining an FMD parameter value based on the measurement data, establishing a diagnostic threshold based on patient medical information, determining a diagnostic result of the FMD test by comparing the FMD parameter value to the diagnostic threshold, and determining a treatment based on the diagnostic result. The image data may correspond to a response to a flow-mediated dilation (FMD) test. The FMD parameter value may quantify an arterial wall's ability to recover from the FDM test.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and / or shearing of matter (i.e. thrombus) from a wall of the body lumen (i.e. a vein or an artery). The radially expansible member has a proximal end and a distal end and is adjustable between a contracted orientation and an expanded orientation. The elongated control member comprising a proximal arm connected at or adjacent to the proximal end of the radially expansible member and a distal arm connected at or adjacent to the distal end of the radially expansible member such that movement of one arm relative to the other arm effects adjustment of the diameter or radial strength of the radially expansible member. The device comprises a control mechanism operatively connected to both arms and adapted to provide resistance to the movement of one arm relative to the other. The control mechanism may be a biasing means, a brake means, or both.

The present invention relates to a method for determining indicator parameters indicative of the biomechanical behaviour of the arterial wall of a patient, on the basis of a temporal analysis of an oscillometric signal acquired during the deflation phase of the cuff around the arm of the patient, the indicator parameters being extracted from the presence of a first maximum and the possible presence of a second maximum detected on the time-evolution plot of the foot-to-apex time intervals (FATI) identified as belonging to the same cycle for each of the cardiac cycles of the oscillometric signal. The first FATI maximum corresponds to the systolic blood pressure. The second maximum may be in correlation with the modification of the biomechanical properties of the arterial wall, such as increased arterial stiffness or pathological behaviour of the wall.

The present invention relates to a local blood flow shield for the aortic wall, belonging to the technical field of medical surgical instruments. The shield consists of two rods that are cross-hinged to each other and are divided into a pair of rod arms and a pair of rod handles that can be opened and closed relative to each other with the hinge point as the boundary. A chuck is provided at the end of one rod arm; a hood is provided at the end of the other rod arm, and a slidable sleeve is sleeved on the rod arm below the hood; the hood is composed of a telescopic skeleton and a diaphragm covering the skeleton; when the sleeve slides up or down along the other rod arm, it respectively sleeves the skeleton to make the hood form a contracted state or an expanded state; during the operation, when the pair of rod arms are closed and the hood is in the expanded state, the hood and the chuck respectively adhere to the inner surface and the outer surface of the local aortic wall and are opposed to each other. The shield can create a local bloodless surgical field through the enclosed three-dimensional space formed by the hood and the inner surface of the local aortic wall, and at the same time eliminate the sequelae caused by conventional clamping of the aortic wall.

The invention discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheters, the renal artery balloon catheter device comprises a catheter main body, and the outer surface of the catheter main body is fixedly connected with a mounting ring tube. The renal artery balloon catheter device for local cold perfusion is provided with the two fixing liquid bags, the catheter body can be stably fixed to the inner wall of the artery, the catheter is effectively prevented from sliding and shifting in the flushing process, and it is ensured that the cold perfusion position is accurate. Meanwhile, the sealing liquid bag is tightly attached to the inner wall of the artery after being swelled, reliable sealing is formed, and backflow of low-temperature liquid is prevented. The through holes in the mounting ring pipe are annularly and uniformly distributed, so that the cold liquid uniformly enters the liquid bag, the expansion uniformity is ensured, and the fixing and sealing effects are further improved. In the flushing process, the valve reducing mechanism enables the fixed liquid bag and the sealed liquid bag to be always kept plump, low-temperature liquid evenly flows out through the liquid outlet holes, pressure is reduced, the artery wall is prevented from being damaged, and stable and efficient cold perfusion on the kidney is achieved.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

A system for accessing one or more artery in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, the proximal end of the shaft including a first connection portion, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a curve of the sheath lumen, a resilient access-extension tube having an extension lumen extending therethrough, the extension lumen having a distal end and a proximal end, the distal end of the extension lumen configured to hydraulically couple to the sheath lumen at the first connection portion, and sealable opening carried by the access-extension tube and spaced from the distal end of the extension lumen, the sealable opening configured to allow insertion of an elongate medical device into the extension lumen for advancement through the extension lumen when the access-extension tube is coupled to the access sheath, for passage through the extension tube and the sheath lumen, and into the superficial temporal artery of the subject.

There is provided in accordance with an exemplary embodiment of the invention a method and / or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and / or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and / or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and / or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.

An implantable stent for treating hypertension, the stent having a non-circular cross-section so as to reshape the artery in which the implant is deployed so as to increase strain in the arterial walls to amplify strain signals in the arterial walls by the baroreceptors of the artery. The stent can further include pulsatility enhancing windows of the implantable frame to enhance pulsatility of the vessel wall subsequent implantation.