21 results about "Arterial wall" patented technology

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

The application provides an imaging method and device for an arterial wall structure, a soliton light source signal is obtained by preprocessing a laser signal, the soliton light source signal is emitted to a microscopic imaging system, a first target position of a target object is scanned and imaged by the microscopic imaging system, and a third harmonic image and a three-photon fluorescence image are obtained. According to the technical scheme, the soliton light source signal of a specific wavelength is obtained by preprocessing the laser signal in advance, the soliton light source signal has better adaptability to a marker (stronger excitation characteristic), the imaging quality of the third harmonic image and the three-photon fluorescence image after imaging of the microscopic imaging system is improved, direct visualization and easy resolution of different layers of the arterial wall structure are achieved, and the microscopic imaging system configured with a gallium arsenide photomultiplier tube and a gallium arsenic phosphor photomultiplier tube is used, two-channel acquisition is adopted to realize twice scanning and imaging of the first target position of the target object, and the number of obtained image details is ensured.

A system for accessing one or more arteries in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a substantially U-shape or J- shape of the sheath lumen, and a sealable opening carried by the proximal end of the shaft and opening into the shaft lumen, the sealable opening configured to allow passage of the elongate medical device through the sheath lumen, and into the superficial temporal artery of the subject.

A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and / or shearing of matter (i.e. thrombus) from a wall of the body lumen (i.e. a vein or an artery). The radially expansible member has a proximal end and a distal end and is adjustable between a contracted orientation and an expanded orientation. The elongated control member comprising a proximal arm connected at or adjacent to the proximal end of the radially expansible member and a distal arm connected at or adjacent to the distal end of the radially expansible member such that movement of one arm relative to the other arm effects adjustment of the diameter or radial strength of the radially expansible member. The device comprises a control mechanism operatively connected to both arms and adapted to provide resistance to the movement of one arm relative to the other. The control mechanism may be a biasing means, a brake means, or both.

This invention discloses a pulse-release balloon dilation pump and method for intracranial arterial stenosis. Addressing the mechanical mechanism of thin intracranial arterial walls and irregular plaques leading to axial stress accumulation and subsequent complications such as dissection and detachment, this invention adds a pulse-release control unit to a conventional pressure pump. Its core physical principle is as follows: When the balloon dilates at an irregular plaque, the intramural strain energy density distribution is uneven. Static friction constraint keeps the system in a high-energy metastable state, and the accumulated elastic potential energy ΔU continuously increases with expansion. The constraint factor λ is defined as F_required / f_max; when λ>1, the balance is unstable, and energy suddenly bursts. This invention uses periodic short-term pressure release to instantaneously decrease the contact pressure, reduce the static friction limit, and briefly raise λ to >1, actively triggering micro-slippage, releasing a small portion of the accumulated energy each time, achieving segmented and gentle energy release. Pulse parameters (amplitude, frequency, etc.) can be flexibly adjusted according to actual clinical conditions. The pulse mode offers flexible and diverse usage options. Operators can initiate it synchronously in the early stages of dilation, when risk signs appear, intervene as needed during pressure application, or combine multiple methods, allowing the operator to independently determine the operational procedure. Based on thin-film mechanics, tribology, and viscoelasticity theories, this invention is simple to operate, does not alter the clinical procedure, and effectively reduces the risk of complications during intracranial artery stenosis balloon angioplasty.

Described is a method and device for dilating a tubular anatomical structure. The device and method can be useful for extracting a blood clot in an artery of a mammal by concentrically irradiating an inner wall of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber. Dilation results from photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall.

The invention discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheters, the renal artery balloon catheter device comprises a catheter main body, and the outer surface of the catheter main body is fixedly connected with a mounting ring tube. The renal artery balloon catheter device for local cold perfusion is provided with the two fixing liquid bags, the catheter body can be stably fixed to the inner wall of the artery, the catheter is effectively prevented from sliding and shifting in the flushing process, and it is ensured that the cold perfusion position is accurate. Meanwhile, the sealing liquid bag is tightly attached to the inner wall of the artery after being swelled, reliable sealing is formed, and backflow of low-temperature liquid is prevented. The through holes in the mounting ring pipe are annularly and uniformly distributed, so that the cold liquid uniformly enters the liquid bag, the expansion uniformity is ensured, and the fixing and sealing effects are further improved. In the flushing process, the valve reducing mechanism enables the fixed liquid bag and the sealed liquid bag to be always kept plump, low-temperature liquid evenly flows out through the liquid outlet holes, pressure is reduced, the artery wall is prevented from being damaged, and stable and efficient cold perfusion on the kidney is achieved.

A system for accessing one or more artery in a head and neck area of a patient includes an access sheath including a tubular shaft having a distal end and a proximal end and a sheath lumen extending therethrough, the distal end of the shaft configured for placement through a puncture in skin and an adjacent arterial wall of a superficial temporal artery of a subject and to extend retrogradely within a portion of the superficial temporal artery of the subject, the proximal end of the shaft including a first connection portion, an intermediate portion of the sheath located between the distal end of the shaft and the proximal end of the shaft, the intermediate portion forming a curve of the sheath lumen, a resilient access-extension tube having an extension lumen extending therethrough, the extension lumen having a distal end and a proximal end, the distal end of the extension lumen configured to hydraulically couple to the sheath lumen at the first connection portion, and sealable opening carried by the access-extension tube and spaced from the distal end of the extension lumen, the sealable opening configured to allow insertion of an elongate medical device into the extension lumen for advancement through the extension lumen when the access-extension tube is coupled to the access sheath, for passage through the extension tube and the sheath lumen, and into the superficial temporal artery of the subject.

There is provided in accordance with an exemplary embodiment of the invention a method and / or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and / or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and / or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and / or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.

The invention relates to a device (100) for preventing and / or curing a vascular accident, for treating thrombosis that forms a clot in an artery, or an aneurysm that forms an aneurysmal sac on an artery, the device comprising: - a cylindrical structure (105), which can be deployed from a microcatheter to the walls of an artery, extends along an axis from an open proximal end (110) to a closed distal end (115), and is configured to be received on the walls of an artery; - a dome-shaped head (125) with a dimpled base defined by a distal ellipsoidal perimeter (130) and a proximal apex (135) with a concave profile, said head being configured to be received on the walls of the artery or the walls of the neck of the aneurysmal sac; and - a joining point (145) that connects the proximal apex (135) of the head (125) to the distal end (115) of the cylindrical structure (105).

The application relates to a wearable ultrasonic transducer-based blood pressure monitoring method and system, which comprises the following steps: obtaining ultrasonic continuous images of an artery to be monitored by an ultrasonic transducer, and acquiring continuous position change information of an arterial wall; obtaining continuous change information of an arterial diameter with time according to the continuous position change information of the arterial wall; and obtaining continuous blood pressure data according to an arterial diameter-blood pressure relationship and in combination with the continuous change information of the arterial diameter with time; wherein the establishment of the arterial diameter-blood pressure relationship is as follows: selecting a suitable superficial limb artery as a measurement area, and determining a calibration blood vessel; obtaining calibration information of the calibration blood vessel by using a sphygmomanometer and the ultrasonic transducer; obtaining an ultrasonic echo time difference between an arterial anterior wall and an arterial posterior wall by the ultrasonic transducer, and obtaining an arterial diameter; and fitting the calibration information and the arterial diameter to obtain the arterial diameter-blood pressure relationship. Compared with the prior art, the application realizes real-time continuous monitoring of the blood pressure of a human superficial artery.

The application provides a traditional Chinese medicine composition for treating pulmonary arterial hypertension and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is composed of ginseng, astragalus, cassia bark, prepared licorice, prepared rehmannia, angelica, white peony root, chuanxiong, persicae semen and safflower. The preparation method is as follows: water is added to decoct and extract to obtain a traditional Chinese medicine extract; the traditional Chinese medicine extract can be further concentrated into a clear paste, and excipients are added to prepare other dosage forms. Animal experiments show that the traditional Chinese medicine composition can significantly reduce the pulmonary arterial pressure of a hypoxic pulmonary arterial hypertension model rat, reduce the right ventricular hypertrophy index, reduce the wall thickness percentage and area percentage of pulmonary arterioles, increase the lumen area percentage of pulmonary arterioles, and effectively improve pulmonary vascular remodeling; clinical cases show that the traditional Chinese medicine composition can significantly improve the symptoms of pulmonary arterial hypertension and heart failure. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood, removing blood stasis and dredging collaterals, can be used for preventing and / or treating pulmonary arterial hypertension, and has good safety.

A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the overall plaque site.

A method includes the step of inserting a catheter inside a vein adjacent to an artery and inflating a balloon within the vein. A focus of a reflector for a shockwave emitter on the catheter is adjusted to be within the artery. The method further includes generating a shockwave within the balloon and directing the shockwave via the reflector through the wall of the vein and the wall of the artery.

Methods, apparatus, and kits for forming flow couplings between veins and arteries are provided. The apparatus may comprise a tubular body with a cutting tip at a distal end thereof. The lumen of the tubular body is pushed over two wires, one located in a vein, the other in an artery. As the tubular body is pushed over the wires, the wires can squeeze the vein and artery walls together, and the cutting tip slices adjacent openings in the vein and artery. The adjacent openings may form a natural fistula without additional measures taken to seal them together, or the adjacent openings may be connected with sutures, cauterizing, or the like to form a fistula.

There is provided in accordance with an exemplary embodiment of the invention a method and / or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and / or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and / or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and / or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.

The present technology relates to devices for treating arteries. In several embodiments, for example, the present technology comprises an expandable structure configured to be intravascularly positioned within a lumen of the artery at a treatment site, where the artery has a substantially circular cross-sectional shape at the treatment site prior to deployment of the expandable structure therein. When the expandable structure is in an expanded state and positioned in apposition with the arterial wall at the treatment site under diastolic pressure, the expandable structure may force the artery into a non-circular cross-sectional shape. A cross-sectional area of the artery in the non-circular cross-sectional shape may be less than a cross-sectional area of the artery in the substantially circular cross-sectional shape.

TITLE OF THE INVENTION: PREVENTIVE AND / OR CURATIVE DEVICE FOR VASCULAR ACCIDENT The preventive and / or curative device (100) for treating a thrombosis forming a clot in an artery or an aneurysm forming an aneurysmal sac on an artery comprises: - a cylindrical structure (105), deployable from a microcatheter to the walls of an artery, extending along an axis from an open proximal end (110) to a closed distal end (115), configured to lodge on the walls of an artery, - a cup-shaped head (125) with a bumpy base, defined by a distal ellipsoidal perimeter (130) and a proximal apex (135) with a concave profile, configured to lodge on the walls of the artery or the walls of the aneurysmal sac at the level of the neck, and - a junction (145) connecting the proximal apex (135) of the head (125) and the distal end (115) of the cylindrical structure (105). Figure for the abbreviation: Figure 1

The application discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheter devices, which comprises a catheter main body, and an installation ring pipe is fixedly connected to the outer surface of the catheter main body. The renal artery balloon catheter device for local cold perfusion has two fixed liquid sacs, can stably fix the catheter main body to the inner wall of an artery, effectively prevents the catheter from sliding and deviating during the flushing process, and ensures the accuracy of the cold perfusion position. Meanwhile, the sealed liquid sac is tightly combined with the inner wall of the artery after being inflated, forms reliable sealing, and prevents the backflow of low-temperature liquid. The internal through holes of the installation ring pipe are annularly and uniformly distributed, cold liquid is uniformly introduced into the liquid sac, the uniformity of expansion is ensured, and the fixing and sealing effects are further improved. During the flushing, the pressure reducing valve mechanism keeps the fixed liquid sac and the sealed liquid sac inflated at all times, the low-temperature liquid is uniformly discharged through multiple liquid outlet holes, the pressure is reduced, the arterial wall is prevented from being damaged, and stable and efficient cold perfusion of the kidney is realized.

To provide a method and apparatus for dilating a tubular anatomical structure.SOLUTION: An apparatus and method for dilating a tubular anatomical structure may be useful for extracting blood clots in a mammalian artery by concentrically illuminating the inner wall 102 of the occluded artery using an ultraviolet (UV) laser beam delivered by an optical fiber 101 having an external or inverted conical tip. Dilation results from the photophysical production and release of nitric oxide from the cells lining the arterial wall when UV laser light is projected as a ring beam onto the inner arterial wall. This "minimal contact persistent dilation system" prepares the artery for safer mechanical extraction by thrombectomy due to reduced friction and dissolution of chemical bonds.SELECTED DRAWING: Figure 1A