68 results about "Arterial occlusions" patented technology

This invention relates to a new type of apparatus designed to modulate the neurovegetative system and integrate the neurovegetative action with that of the central nervous system. The method is not invasive, because it uses pulses transmitted through the skin; the intensity of the stimulus is controlled directly by the patient in order to achieve better integration with the central nervous system. This invention effectively treats vascular disorders resulting from obstruction of the arteries of the legs, heart and brain because it induces vasodilatation and increases blood flow and the production of new blood vessels. The method also improves lesions of the spinal column, especially those affecting the back and neck, and other orthopaedic disorders.

A neural stimulation therapy system for atherosclerotic plaques is provided. One aspect of this disclosure relates to a medical device for applying neural stimulation therapy for atherosclerotic plaques. The device includes a neural stimulator adapted to deliver an electrical signal through at least one electrode to an autonomic neural target. The device also includes a controller to control the neural stimulator to provide a therapy for atherosclerotic plaques. The device is external to a human body in an embodiment, and includes an implantable medical device (IMD) in various embodiments. According to an embodiment, the device includes a neural stimulation lead connected to the neural stimulator. The neural stimulator delivers electrical signals with waveform parameters based on sensed arterial blockage levels, according to various embodiments. Other aspects and embodiments are provided herein.

Disclosed is a conduit that provides a bypass around a stenosis or occlusion in a coronary artery. The conduit is adapted to be positioned in the myocardium to provide a passage for blood to flow from a heart chamber to a coronary artery, at a site distal to the blockage or stenosis in the coronary artery. The conduit has a one-way valve positioned therein to prevent the backflow of blood from the coronary artery into the heart chamber.

An intravascular catheter system includes an intravascular catheter that can be easily and safely navigated through severely occluded arteries. The system uniquely includes both an optical fiber for use in providing data for guiding the catheter and a conventional metal guide wire for use in navigating the catheter through the artery passageway. The system further includes optical imaging of the arterial occlusion during guidance of the catheter through the artery passageway. More particularly the system provides a visual indication to the surgeon to determine if the catheter assembly is approaching the arterial wall.

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

A system for deploying and selectively inflating a thoracic aortic balloon at a desired location within the thoracic aorta for resuscitative aortic occlusion, inferior to the left subclavian artery, without the aid of fluoroscopy is described. Using CT imaging data, a distance between readily identifiable and consistently located external landmarks of torso extent is measured. Next, using the same data, a second distance from the femoral artery to a desired aortic occlusion location inferior to the left subclavian artery is determined. A correlation between the external measure of torso extent and the desired intra-arterial (i.e. endovascular) distance within the torso is made. Using a nomogram, a calibrated endovascular resuscitative thoracic aortic occlusion system can be positioned to this desired location on any injured individual with end-stage shock and impending cardiovascular collapse or death without the aid of fluoroscopy for delivery or balloon inflation.

Method to obtain continuous recording of the central arterial blood pressure waveform noninvasively utilizes dual (distal occlusion and proximal) brachial artery occlusion cuffs and dual external osculation. The distal arterial occlusion cuff eliminates venous stasis artifact and flow related gradient from aorta to the brachial artery. The proximal cuff measures, and delivers, dual external oscillation. The dual external oscillation allows measurement of the arterial compliance at a multitude of transmural pressure values during each cardiac cycle. Transmural pressure / arterial compliance and arterial pressure curves are subsequently reconstructed using dual external oscillation. The curves consist of two parts, rapid and slow parts, both at the frequency higher than the arterial pulse.

The invention discloses an instrument for arterial occlusion lesion treating and the application thereof. The instrument comprises a vascular ultrasound catheter, a treating micro catheter and a treating guiding line. The vascular ultrasound catheter and the treating micro catheter are integrally connected in parallel. One part of the treating guiding line is placed in the treating micro catheter, and the other part of the treating guiding line penetrates out of the treating micro catheter from a side wall outlet. According to the instrument, the vascular ultrasound catheter and the treating micro catheter are integrally connected in parallel, a double-cavity micro catheter is used for adjusting the treating guiding line to enter a vessel true lumen, thrombus is sucked out through the treating guiding line, and post-operation hidden danger is removed through one-time curing. The problem that in an intervention recanalization treating operation of blocking of coronary arteries, peripheral arteries and other organ pipelines, a treating guiding line cannot enter a true lumen easily is solved.

The invention relates to prostaglandin microemulsion-gel preparation and a preparation method thereof. The preparation comprises prostaglandin E1 or the derivative thereof, oil, emulsifier, assistant for emulsifying agent, gel substrate and water, and also possibly comprises a permeation accelerator, a preparation stabilizer, an antioxidant and antiseptics. The preparation has the advantages of good percutaneous permeability, no stimulation to skin and mucous membrane, simple preparation technique and stable quality, the preparation can be used for treating diseases such as ulcer of limbs caused by erectile dysfunction and chronic arterial occlusion and rest pain of limbs caused by microcirculatory disturbance.

The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A medical-related apparatus is provided comprising a medical-related device having provided thereto a therapeutic amount of a collagen degrading composition comprising a proteiolytic enzyme containing formulation. A method is provided for treating chronically occluded animal tubes and cavities by administering a therapeutic effective amount of a proteolytic enzyme-containing formulation adjacent to an occluding atherosclerotic plaque, waiting for a pre-angioplasty waiting period, followed by crossing the plaque with an angioplasty guide wire.

A system for deploying and selectively inflating a thoracic aortic balloon at a desired location within the thoracic aorta for resuscitative aortic occlusion, inferior to the left subclavian artery, without the aid of fluoroscopy is described. Using CT imaging data, a distance between readily identifiable and consistently located external landmarks of torso extent is measured. Next, using the same data, a second distance from the femoral artery to a desired aortic occlusion location inferior to the left subclavian artery is determined. A correlation between the external measure of torso extent and the desired intra-arterial (i.e. endovascular) distance within the torso is made. Using a nomogram, a calibrated endovascular resuscitative thoracic aortic occlusion system can be positioned to this desired location on any injured individual with end-stage shock and impending cardiovascular collapse or death without the aid of fluoroscopy for delivery or balloon inflation.

The invention provides phascolosoma esculenta plasmin, which is extracted from phascolosoma esculenta, and has double activities of directly dissolving fibrin and kinase. The phychemical performance of the plasmin is that: the molecular weight is between 28,000 and 32,000, the isoelectric point is between 4.6 and 6.6, the dissolution activity of fibrin does not change greatly under a temperature range between 30 and 70 DEG C, and the stability range to the pH value is between 5.0 and 9.0. The phascolosoma esculenta plasmin has the direct fibrin and kinase dissolving activities, has simple extracting process, low preparation cost and easily obtained raw materials, can be developed into intravenous injection, contains the plasmin capable of directly dissolving thrombus, and is expected to obtain better effect in treating catheter assisted thrombolysis treating peripheral arterial occlusion and deep venous thrombosis.

This invention relates to a new type of apparatus designed to modulate the neurovegetative system and integrate the neurovegetative action with that of the central nervous system. The method is not invasive, because it uses pulses transmitted through the skin; the intensity of the stimulus is controlled directly by the patient in order to achieve better integration with the central nervous system. This invention effectively treats vascular disorders resulting from obstruction of the arteries of the legs, heart and brain because it induces vasodilatation and increases blood flow and the production of new blood vessels. The method also improves lesions of the spinal column, especially those affecting the back and neck, and other orthopaedic disorders.

This paper describes a system and method invention for blood vessels cleaning, such as a coronary artery, peripheral artery, or any other body vascular based on a mobile agent. The system consists of device which is electronically controlled, performing a procedure of vessel walls cleaning by removing the accumulated plaque or any other blockage material. This plaque or other blockage type may cause atherosclerosis and can eventually cause the artery to be blocked, causing heart disease, heart attack or stroke. Upon initial setup the system will be inserted into a human body and travel within its blood vessels. Based on sensors the system finds clogged areas and remove the blockage, without damaging the vessel's tissue using its cleaning system. The system independently and / or programmatically travels and searches for blockages within blood vessels using its own propulsion and navigation system. The system includes also a mechanism to remove and collect the removed plaque or any other blockage material. This system performs an efficient blood vessels cleaning and provides an innovative non surgical method for blood vessels blockage removal.

The invention relates to an auxiliary bandaging device for an elastic bandage, and belongs to the technical field of medical equipment. The auxiliary bandaging device is used for the postoperative hemostasis bandaging of the elastic bandage, and is characterized by comprising an upper fixing plate and a lower fixing plate, wherein the upper fixing plate is placed at a waist, the inner lateral surface of the upper fixing plate imitates the shape of the waist, and the outer lateral surface of the upper fixing plate is provided with salient points, grooves, fixing holes or sheaths; the lower fixing plate is placed outside thighs, the inner lateral surface of the lower fixing plate imitates the shapes of the thighs, and the outer lateral surface of the lower fixing plate is provided with salient points, grooves, fixing holes or sheaths; and the auxiliary bandaging device also comprises a front fixing plate an a rear fixing plate according to actual requirements. After patients do operation, the elastic bandage winds on the auxiliary bandaging device, so that the elastic bandage can be prevented from sliding and curling effectively; and compared with the conventional bandage hemostasis method, the auxiliary bandaging device has the advantage that after the auxiliary bandaging device is adopted, the bandage is not tied in flesh, so that the pain of the patients is relieved effectively. By using the auxiliary bandaging device for the elastic bandage, pressure can be reduced at any time according to actual requirements, so that the arterial occlusion of lower limbs and deep venous thrombosis of the patients are avoided.

A method for treating uterine leiomyomas, which includes vaginally accessing the cardinal ligament surrounding at least one uterine artery, and occluding the flow of blood through the least one uterine artery. The blood can be occluded by compression. The artery can be compressed by ligating the cardinal ligament. In addition, at least one uterosacral ligament can be ligated. In addition, the artery can be compressed by, clipping, stapling or clamping the cardinal ligament. The blood can also be occluded by coagulating the at least one artery. Coagulation can be done with a laser or a cauterizing device. A system for treating uterine leiomyomas, which includes vaginally accessing the cardinal ligament surrounding at least one uterine artery using a surgical suture passing device to extend a ligature around the ligament, and affixing a ligature around the cardinal ligament to occlude the flow of blood through at least one uterine artery. Also, a system for treating uterine leiomyomas, which includes vaginally accessing the cardinal ligament surrounding at least one uterine artery, providing an absorbable clip and / or staple, and affixing the clip and / or staple around the ligament to occlude the flow of blood through the at least one uterine artery.

Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.

A method for digital thermal monitoring assessment of vascular function comprising a temporary arterial occlusion using a pneumatic cuff positioned on a subject's upper limb, monitoring skin temperature at the fingertip of the occluded limb for a period of time before, during, and after the occlusion, calculating a Zero Reactivity Curve based on variables including start temperature, room temperature, and the slope of temperature decline during the occlusion, and assessing vascular function based on comparing the Zero Reactivity Curve and the observed temperature rebound after the occlusion is removed. A vascular reactivity monitoring apparatus for measuring skin surface temperature comprising an inflatable cuff for placement around a subject's limb, a digital thermal measuring device and photoplethysmography measuring device for placement on a finger of the subject's limb wearing the cuff and a second digital monitoring device and photoplethysmography measuring device for placement on a finger of the subject's contralateral limb.

Devices, and methods for synchronizing cerebro-hemodynamic signals are disclosed. In one aspect, the devices and methods may include synchronizing first and second signals indicative of hemodynamic characteristics within a subject's brain. Differences may be determined between the synchronized signals and used to provide information for diagnosing changes in arterial occlusion. Differences between the synchronized signals may include differences, such as timing delays, between signature features of the synchronized signals. The first and second signals may be indicative of hemodynamic characteristics in first and second hemisphere's of a subject's brain. The first and second signals may be bioimpedance signals.

A temporary aortic occlusion device is disclosed, having an expandable locator portion and an expandable occlusion portion. The expandable locator portion assists a user in determining whether the distal end of the device has been advanced within a patient's aorta, and the occlusion portion is expanded to occlude the patient's aorta, preferably below the renal arteries.

The invention relates to sipunculus nudus plasmin which is extracted from sipunculus nudus and has double activities of directly dissolving fibrin and kinase. The sipunculus nudus has the materialization performances that the molecular weight ranges from 27000 to 35000, the isoelectric point ranges from 4.5 to 7.0, the dissolving activity of fibrin varies little within the temperature range of 30 to 70 degrees centigrade, and the stability range of the pH value ranges from 5.0 to 9.0. The sipunculus nudus plasmin has double activities of directly dissolving the fibrin and the kinase, simple extraction process, low preparation cost and easily obtained materials, can be developed into vein injection, contains the plasmin for directly degrading thrombus and is expected to have better effect on treating periphery arterial occlusion and deep vein thrombosis in a conduit-assisted thrombolytic therapy.

An endovascular apparatus is provided for treating the effects of vascular disease including aneurysms and arterial blockages using a percutaneous, minimally invasive technique. In one embodiment the endovascular apparatus includes a tubular sleeve having a cranial end, a first caudal branch, and a second caudal branch such that the tubular sleeve is shaped like an upside down “Y.” The apparatus further includes at least one expandable attachment device attached to the tubular sleeve for securing the endovascular apparatus to an interior wall of a vessel. The at least one expandable attachment device includes a plurality of telescoping segments similar to the telescoping segments of a presentation pointer. Accordingly, during percutaneous insertion of the endovascular apparatus into a patient the attachment device can be collapsed into a small profile. Once positioned at the site of the aneurysm the telescoping attachment device can be expanded to hold the endovascular apparatus in place adjacent the inner lumen wall.

A thrombolysis catheter apparatus is disclosed comprising: (a) an elongated thrombolysis catheter portion comprising a plurality of independently controllable electroactive polymer actuators, which provide a curvature to the thrombolysis catheter based upon received control signals; (b) a control unit coupled to the plurality of actuators and sending the control signals to the plurality of actuators; and (c) an occlusion removal device. Also disclosed is a method of treating an arterial occlusion by advancing the thrombolysis catheter portion through the arterial vasculature of a patient to a position proximate the occlusion, while controlling the shape of the thrombolysis catheter portion using the control unit. The occlusion is then removed using the occlusion removal device.

A temporary aortic occlusion device is disclosed, having an expandable locator portion and an expandable occlusion portion. The expandable locator portion assists a user in determining whether the distal end of the device has been advanced within a patient's aorta, and the occlusion portion is expanded to occlude the patient's aorta, preferably below the renal arteries.

A method for the prevention or treatment of intraocular angiogenic diseases such as proliferative retinopathy, retinal vein occlusion, retinal artery occlusion or age-related macular degeneration, which comprises administering to a mammal (such as a human) in need thereof a pharmaceutically effective amount of an angiotensin II receptor antagonist such as 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid.

Methods are described for the isolation and selection of a heterogeneous bone marrow cell population, called NCS-01, that is effective at treating neurodegeneration. For example, NCS-01 cells are shown to treat neurodegeneration caused by ischemia. In vivo studies demonstrate that selected NCS-01 cell populations treat neurodegeneration in a standard rat middle cerebral artery occlusion (MCAO) animal model under conditions of transient or permanent total arterial occlusion. These studies also disclose that when the neurodegeneration is caused by ischemic stroke, combining the administration of a selected NCS-01 cell population with thrombolytic agents and / or mechanical methods of clot removal leads to a decrease in the volume of infarction caused by acute onset neurodegeneration. The disclosed cell therapy promises to make a significant clinical impact on patient survival after stroke.