42 results about "Increased blood flow" patented technology

The invention provides a method for preparing quintuple diglyceride oil for improving blood vessel health through enzymolysis, application and a product, and belongs to the technical field of enzyme engineering. The preparation method comprises the following steps: mixing low-erucic acid rapeseed oil, glycerol, water, fatty acid and lipase, and carrying out enzymolysis reaction, molecular distillation, decoloration and deodorization to obtain diglyceride oil; the lipase is a mixture of Candida antarctica Aspergillus niger lipase, Candida column lipase and bovine pancreas lipase, and the weight ratio of the low-erucic acid rapeseed oil to the glycerin to the water to the fatty acid to the lipase is 500: (80-100): (1-2): (30-60): (10-20). The diglyceride oil prepared by the method can be used for preparing a diglyceride oil composition, and has five functions of reducing blood uric acid, reducing blood total cholesterol, reducing blood triglyceride, reducing blood sugar and increasing blood flow velocity to improve blood vessel health.

The invention relates to a dietary therapy formula for improving microcirculation of inner ears and a preparation method. Components with homology of medicine and food are selected, the black rice, the blueberries and the purple cabbages are rich in anthocyanin and beneficial to removing free radicals in cochlea and inhibiting hair cell apoptosis, the walnut kernels and the Chinese wolfberry fruits can improve blood vessel elasticity and protect auditory neurons, and the radix salviae miltiorrhizae, the hawthorn fruits and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, reduce blood viscosity and reduce vasospasm, so that the health-care food is suitable for being eaten by people. The whole component is low in sugar content, suitable for diabetics and capable of expanding the crowd. Effective components are processed into non-medicinal products, food therapy is beneficial to improving microcirculation of inner ears, relieving ear symptoms such as tinnitus and the like and delaying hearing loss, and a user can eat the food for a long time without psychological burden of medication.

A system for monitoring hemodynamic effectiveness includes a lead assembly including a lead body configured to deliver electrical stimulation or to deliver a fluid. The system includes at least one stimulation source including a drug pump or a pulse generator, a sensing device configured to detect a hemodynamic property of a body part, and a processor configured to determine hemodynamic effectiveness based on the detected hemodynamic property. Hemodynamic properties may include vasodilation, vasoconstriction, increased blood flow, decreased blood flow, or other hemodynamic changes. A method for providing treatment includes positioning a lead body adjacent to a blood vessel, obtaining a baseline hemodynamic property, administering stimulation, detecting an updated hemodynamic property, and determining hemodynamic effectiveness based on a change between the baseline and updated hemodynamic properties. A closed-loop treatment system adjusts treatment values based on measurements detected by the sensing device to cause stimulation to reach target values.

The present invention provides extracellular vesicle compositions. Also provided are methods of making an extracellular vesicle loaded scaffold using the extracellular vesicle compositions to increase revascularization. Methods of using the extracellular vesicle compositions and the extracellular vesicle loaded scaffold are provided. The scaffold may increase blood flow and oxygenation of the tissue thereby aiding in treatment of disease and injury.

The present invention discloses a composition for treating hypothyroidism. The formula includes: placenta, antler, Pseudostellaria baicalensis, Salvia miltiorrhiza, and Herba Lycopodii. The prescription of the present invention is demonstrated to have therapeutic effects on hypothyroidism from both traditional Chinese medicine and modern medicine perspectives: from the perspective of traditional Chinese medicine, the efficacy of the present invention in replenishing qi and blood, regulating yin and yang, tonifying kidney essence, filling the marrow sea, and unblocking meridians is unique in treating goiter. From the perspective of modern medicine: Panlushending Jiawei Decoction has the effects of promoting cell reproduction, differentiation, and repairing damaged cells, and is also anti-apoptotic. It also has the effects of promoting the regeneration of vascular endothelial cells, forming new blood vessels, increasing blood flow rate, increasing blood supply, and increasing the secretion and synthesis of thyroid hormones. It can also increase the level of free hormone reabsorption from the intestine and lower the concentration of antibodies.

A method of producing an arteriovenous (AV) fistula includes producing an anastomosis between a primary blood vessel (e.g., a vein) and a secondary blood vessel (e.g., an artery). A collateral (or competing) blood vessel in fluid communication with one of the primary blood vessel or the secondary blood vessel is identified. A reversible flow restrictor is then applied to the collateral blood vessel to reduce a blood flow rate through the collateral blood vessel. In some embodiments, the anastomosis can be produced percutaneously. In some embodiments, the reversible flow restriction (or a portion thereof) can be removed from the collateral blood vessel. In other embodiments, the reversible flow restriction (or a portion thereof) can be adjusted to allow increased blood flow therethrough while within the collateral blood vessel.

The invention discloses a negative pressure rolling shaft handle and device, the handle comprises a working body, a rolling shaft assembly and a main controller, the working end of the working body is provided with a negative pressure cavity, one side of the negative pressure cavity is provided with an opening used for making contact with the skin, and the negative pressure cavity is internally provided with a laser lamp facing the opening and a radio frequency element; the rolling shaft assembly comprises a rolling shaft rotationally arranged in the negative pressure cavity; the negative pressure pipeline, the laser lamp, the radio frequency element and the driving element are all electrically connected with the main controller, and the main controller controls the negative pressure value and time length of the negative pressure pipeline for extracting the negative pressure cavity, controls the power and time length of the laser lamp and the radio frequency element and controls the rotating speed of the driving element for driving the rolling shaft according to received and stored working information. Under the action of electromagnetic waves and laser, fat is liquefied and dissolved and can be discharged out of the body through normal metabolism of the human body, and accumulated fat is rapidly reduced; the rolling shaft rotates to massage human tissues, blood flow and oxygen supply are increased, and fat metabolism is accelerated.

The present invention discloses a method for improving the solid tumor enrichment ability of red blood cell carriers, specifically: a small molecule compound RRx-001 is loaded into the red blood cell carrier, RRx-001 causes the PS molecules on the surface of the red blood cells to be everted, which can mediate the targeted adhesion of red blood cells to tumor vascular endothelial cells expressing PSR protein, thereby achieving active targeting of tumors. In addition, the present invention transforms red blood cells by RRx-001, thereby enhancing the ability of red blood cells to produce NO, dilates tumor blood vessels by NO, and increases blood flow in tumor blood vessels. The present invention transforms red blood cells by RRx-001 so that they have the performance of both tumor targeting and generating NO to dilate tumor blood vessels, thereby achieving effective enrichment of chemotherapy drugs at the tumor site, and is applicable to all solid tumors, so the present invention is of great significance for drug delivery to tumors.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition comprises the following components in parts by weight: 7-11 parts of champignon, 19-29 parts of aloe, 10-14 parts of fructus chebulae immaturus, 5-7 parts of rhizoma zingiberis, 5-7 parts of rhizoma nardostachyos, 4-6 parts of fructus chebulae and 2-4 parts of halite. The traditional Chinese medicine composition can improve the activity of SOD, inhibit the content of MDA, reduce damage of oxygen free radicals to gastric mucosa, effectively relieve inflammatory response, achieve anti-inflammation, improve ulcer surface blood flow, improve gastric mucosa damage, reduce ulcer surfaces and promote ulcer healing, and therefore the protective effect on gastric ulcer is achieved. The results of network pharmacology, molecular docking speculation and Western blot method verification show that the FMST plays an anti-inflammatory role through a TLR4 / MyD88 / NF-kappa B signal channel.

A wearable radiation emitting device with integrated vibration element which operates to provide for the use of radiation treatment in conjunction with vibration treatment. The wearable radiation emitting device with integrated vibration element includes a plurality of LEDs, some of which emit blue visible light and others which emit red visible light and infrared light, and are arranged to direct these emissions to an injury site so as to reduce general pain as well as promote a wearer's recovery by way of increased blood flow and infection prevention. The wearable radiation emitting device with integrated vibration element also includes a plurality of integrated vibrating pads operative to generate vibration around an injury site that also promotes increased blood flow as well as stimulates the lymphatic system, all of which promotes systemic healing and aids in infection prevention and swelling reduction.

Provided herein are FLT1 binding proteins, as well as related nucleic acids, vectors, host cells, pharmaceutical compositions and kits. The present disclosure additionally provides methods of treating a subject in need thereof, including subjects in need of treatment for PAD, CLI, ANOCA, or heart failure (HF). Further provided are methods of increasing VEGF-mediated and / or PlGF-mediated signal transduction in a subject, which, in turn, increases blood flow, capillary density, capillary or coronary growth, and / or cardiac perfusion in the subject. The present disclosure further provides methods of reducing blood pressure and risk of heart failure in a subject. In exemplary embodiments, each of the methods comprise administering to the subject a pharmaceutical composition of the present disclosure. In various embodiments, the pharmaceutical composition comprises a FLT1 binding protein of the present disclosure.

The invention relates to the technical field of medicines, in particular to sound-induced piezoelectric hydrogel as well as a preparation method and application thereof. The method comprises the following steps: 1) synthesizing a nano-plate by adopting a hydrothermal method; or in the process of synthesizing the nano-plate by the hydrothermal method, adding an iron source into the reaction liquid, and carrying out hydrothermal reaction to obtain the iron-doped nano-plate, (2) carrying out lamellar stripping on the nano-plate to obtain a nano-sheet; and 3) preparing gelatin gel, and then mixing the gelatin gel with the nanosheets obtained in the step 2) to obtain the sound-induced piezoelectric hydrogel. The piezoelectric-like material is innovatively applied to treatment of infected wounds, the piezoelectric-like material serves as a novel piezoelectric material, the acoustic heating effect can be rapidly generated under low-power ultrasonic induction so as to treat the biological membrane infected wounds, and in addition, the temperature rise can promote wound healing by increasing the blood flow volume, promoting cell migration and the like.

The utility model discloses a limb pressure sleeve capable of being used for cold and hot compress, which comprises a pressure sleeve body, an air pipe arranged in the pressure sleeve body, a plurality of air bags symmetrically arranged on one side face of the pressure sleeve body, a contact layer arranged on one side face of the pressure sleeve body, a heating film arranged between the contact layer and the pressure sleeve body, and a cable arranged in the pressure sleeve body. A plurality of notches are symmetrically formed in one side face of the contact layer, a storage bag is arranged on one side face of the contact layer and located among the notches, and a second hook-and-loop fastener thorn face is arranged on one side face of the inner wall of the storage bag. The heating film is heated through power supply of the cable, the heating film is a carbon nano tube / TPU composite film, the heating film is started to heat the legs, and heating can enable local blood vessels to expand, increase blood flow, improve the conveying efficiency of oxygen and nutrient substances, accelerate discharge of metabolic waste, reduce blood viscosity and reduce blood flow resistance, so that the legs are protected from being damaged. The pharmaceutical composition is of clinical significance to patients with hyperlipidemia or diabetes mellitus.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating acute heart failure and a preparation method thereof. A compound formed by combining propylene glycol monooleate and cathepsin K covers the surface of a mesoporous carbon sphere with a high specific surface area, freezing nano spray drying is performed, the obtained nano particles adsorb a repair promoting solution, and the prepared load reducing particles can target myocardial cells for treatment; after aesculus chinensis, affine cudweed and witch hazel are crushed and extracted, the obtained blood vessel expanding extract is mixed with a blood circulation promoting solution, blood vessels are effectively expanded, the blood flow volume is increased, sodium carboxymethyl cellulose is modified by hydrochloric acid and then reacts with calcium carbonate, and formed modified calcium carboxymethyl cellulose is high in disintegration performance; the anti-infection and side effect reducing agent is sprayed on the surface of the tablet for treating acute heart failure, and the prepared traditional Chinese medicine composition for treating acute heart failure has the advantages of high disintegration speed, comprehensive and efficient treatment effect, long-acting effect, strong drug stability and high bioavailability.

The invention relates to a dietary therapy formula for repairing ear hearing nerve cells and a preparation method thereof. Components with homology of medicine and food are optimally selected, the salvia miltiorrhiza and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, inhibit vasospasm of the inner ears and reduce ischemic injury of hair cells, alpha-linolenic acid is provided for a human body by utilizing the flaxseeds and the walnuts and converted into DHA, the DHA directly participates in nerve myelin sheath reconstruction, auditory nerve signal conduction is enhanced, and the health care effect is achieved. Chinese yam and astragalus membranaceus can provide Chinese yam polysaccharide and astragaloside, the mitochondrial function is improved, and cell apoptosis is delayed. The whole component is low in sugar content, is suitable for diabetics, expands the application crowd and non-medicine products, can reduce the psychological burden of eaters taking medicines for a long time, and is beneficial to popularization and application.

The application discloses a kind of nanofiber composite dressings with photothermal synergistic antibacterial effect and its preparation method.The method is by in-situ growth COF is loaded on the fiber membrane, then resveratrol is loaded in COF, finally, PPrGO / RES-COF@PAN nanofiber composite dressings are prepared by drawing filtration reductive graphene oxide coating on the membrane.The PPrGO / RES-COF@PAN nanofiber composite dressings of the application has excellent photothermal performance, can synergistically exert bactericidal effect with resveratrol;At the same time, appropriate temperature rise can increase blood flow and ion diffusion rate across cell membrane, and activate heat shock protein, promote cell migration;In addition, the nanofiber composite dressings has good water vapor permeability, porosity and biocompatibility, and can effectively improve inflammation, has good application value for promoting wound healing.

The invention discloses a tongue exercise and respiration collaborative conditioning method for improving refractory insomnia, and relates to the field of human health conditioning and sleep medicines.The method comprises the steps that tongue exercise exercise of a preset duration is executed in the period before sleep every day, abdominal or inverse abdominal respiration regulation is conducted in a synchronous and matched mode, and therefore tongue muscle groups are activated. In the morning or before afternoon every day, a skin needle therapy (oblique puncturing for 0.5 mm) and a bloodletting therapy are performed on specific acupuncture points (such as Yingwei points) in the oral cavity so as to activate and disperse blood stasis and increase qi and blood flow. Through the synergistic effect of lingual exercise, breathing conditioning and skin needle / bloodletting therapy, the blood supply state of the brain and the heart is improved, so that the intractable insomnia symptom caused by neurasthenia, physical weakness, cardio-cerebral ischemia and the like is relieved from the source. The method emphasizes multi-dimensional collaborative conditioning, can adapt to different crowds, can be dynamically adjusted through effect evaluation, and aims to realize a physical insomnia intervention mode without drug dependence.

Blood flow to the kidney primarily comes from the renal arteries which are controlled by the renal plexus. This plexus is innervated by the sympathetic chain and dorsal root ganglion upstream. In this embodiment neuromodulation of dorsal root ganglion between T8 and L3 can be used to alter renal blood flow and, thus, blood pressure. The neuromodulation at at frequencies between 0.01 Hz and 19.99 Hz at these DRG levels can be used to increase blood flow to the kidneys and to treat hypertension.

The invention belongs to the technical field of health care products, and discloses a composition for improving skin color in multiple ways as well as a preparation method and application thereof. The composition for improving the skin color in multiple ways is prepared from the following components in parts by weight: 5 to 10 parts of paeonia ostii flower extract, 2 to 4 parts of pleurotus citrinopileatus extract and 3 to 6 parts of pomegranate extract. The mass ratio of the paeonia ostii flower extract to the pleurotus citrinopileatus extract is (1.25-5): 1. According to the composition disclosed by the invention, the generation of advanced glycation end products AGEs and reactive oxygen species ROS can be effectively inhibited through the synergistic effect of various active ingredients, the generation of melanin is reduced from the source, and the skin is prevented from blackening and yellowing; collagen synthesis is promoted, and the skin repairing capacity is improved; the blood flow speed is increased, the number of red blood cells is increased, the skin microcirculation is improved, the skin metabolism capability is improved, and then the excellent effect of comprehensively improving the skin color in multiple ways is achieved.

A method for treating a section of skin that includes the epidermis, dermis, and hypodermis. The method includes dermaplaning the section of skin. After dermaplaning, a beam from a non-ablative laser is passed over the section of skin multiple times. The beam of the non-ablative laser further removes dead skin and hair and also warms the underlying dermis and hypodermis. A skin serum is topically applied to the section of skin. The section of skin is treated with electrical arc discharges of a plasma pen to create disruptions in the epidermis. The disruptions created in the epidermis enable the serum to better pass into and through the epidermis. The treated area of skin can then be subjected to light therapy to increase blood flow, promote the healing of the created disruptions, and provide protection against infection.

The utility model relates to the technical field of movable seats, and discloses a movable seat for old people, which comprises a movable seat body, a back massage mechanism is arranged on the outer side of the movable seat body, a leg massage mechanism is arranged at the bottom of the movable seat body, and a soft cushion is arranged at the top of the movable seat body. And universal wheels are arranged at the bottom of the movable seat body. The old people do not need to be massaged by a specially-assigned person, more manpower is saved, in the process that the hand wheels are rotated by the two hands, the arms can be moved, and therefore the arms of the old people can be exercised, the massage rollers are made to rotate, and the backs of the old people are massaged; the back of the old person is massaged in all directions in the rotating process of the massage rollers, a rotating disc is rotated, a lifting frame is jacked by a limiting column, a jacking column slides in a through hole of a movable seat body, hip and legs of the old person are massaged, blood flow is increased, and muscular atrophy is prevented.

This invention discloses a casein-derived small molecule peptide with antihypertensive effect and its preparation method, belonging to the field of bioactive peptide technology. The preparation method is as follows: S1, mix casein with water and stir until homogeneous; S2, add a complex protease for enzymatic hydrolysis, then add bromelain for further enzymatic hydrolysis to inactivate the enzyme; S3, centrifuge the mixture; S4, heat the separated mixture, add activated carbon for adsorption, then add diatomaceous earth, stir until homogeneous, and filter; S5, further filter through a membrane; S6, concentrate the mixture, sterilize, and dry to obtain the casein-derived small molecule peptide. The casein-derived small molecule peptide of this invention can effectively lower blood pressure by inhibiting ACE activity and blocking the production of angiotensin II. This small molecule peptide significantly increases blood flow activity and angiotensin II content in a hypertensive model zebrafish, exhibiting a dose-dependent effect, achieving the same effect as the antihypertensive drug captopril, and with an efficacy concentration that is half that of the positive control drug.

The application discloses a shunt, comprising a tube body, comprising an outer skeleton and an inner skeleton connected, a first through hole is formed on the outer skeleton, the first through hole is arranged along the axial direction of the outer skeleton, the inner skeleton is located on the inner side of the first through hole, the outer wall of the inner skeleton is at least partially spaced from the inner wall of the first through hole, a second through hole is formed on the inner skeleton, and the second through hole is arranged along the axial direction of the inner skeleton. Thus, by spacing the outer wall of the inner skeleton from the inner wall of the first through hole, a certain spacing distance is formed between the outer wall of the inner skeleton and the inner wall of the first through hole, so that a certain deformation space is formed between the inner skeleton and the inner wall of the first through hole. After the left atrial pressure of the patient increases, the inner skeleton can expand towards the radial outside under the pressure of the blood flow, so that the area of the radial section of the second through hole increases, the blood flow passing amount per unit area is increased, and the long-term increased blood flow pressure in the left atrium can be adapted.

The invention relates to a system (1) and method for detecting malfunctions of the neurovascular coupling of a user of a device that can be worn or implanted on the head, in particular a hearing aid (2), long-term monitoring being carried out with the aid of a device worn by the user, in particular a hearing aid. The device has a signal processing unit (8) and a memory (16). The system (1) also has at least two sensors (18, 20, 22), namely a sensor (20) for detecting brain activity and a blood sensor (18, 22) for detecting blood flow to the brain. The at least two sensors (4, 18, 20, 22) are connected to the signal processing unit (8) for transmitting sensor data (A, B), namely brain activity data (A) and blood flow data (B). The signal processing unit (8) is designed to process the sensor data (A, B) in such a way that characteristic data, in particular a characteristic value (K) for a correlation, in particular a time delay between increased brain activity and increased blood flow caused thereby, is determined, and reference characteristic data and in particular a reference characteristic value (RK) are formed therefrom over a relatively long observation period (Z) as a measure of the time delay Z. The reference characteristic data are compared with instantaneous characteristic data recorded later and a warning signal (W) is emitted in the event of an inadmissible deviation.

Disclosed are devices, systems and methods for softening fascia and / or performing mini cupping to increase blood flow to surface and subsurface anatomical structures, including a tool which employs a rotatable hub having a combination of small suction cups and mechanical compression elements positioned thereon.

The present invention provides an immediate volumizing effect, a refreshing sensation, and wrinkle removal effects by including hyaluronic acid and peptides, and provides long-term improvement in lip volume and reverse skin aging effects by including an extract of Silybum marianum petals and an extract of Glycyrrhiza glabra leaves. In addition, the purpose of the present invention is to provide a natural plumping effect through long-term improvement in lip volume, amelioration of wrinkles, and increased blood flow by mixing an extract of Silybum marianum petals, which is an anti-aging component that removes and inhibits senescent cells, with ingredients such as hyaluronic acid and peptides that induce a natural plumping effect by ameliorating wrinkles and increasing blood flow.

The invention discloses a dialysis patient limb warm-keeping dual-purpose device, and particularly relates to the technical field of medical auxiliary instruments, the dialysis patient limb warm-keeping dual-purpose device comprises a limiting cylinder, a supporting connecting assembly is arranged on the limiting cylinder, the supporting connecting assembly comprises an outer wire cylinder arranged in the middle of the limiting cylinder, and a first connecting ring is fixedly arranged at one end of the outer wire cylinder. The limb of a patient is clamped in the mode that a first hinge rod and a tin foil heat insulation cover gather towards the axis of a limiting cylinder and an outer wire cylinder, the phenomenon that the limb of the patient displaces during dialysis can be effectively avoided, the device can adapt to limbs of different sizes, the adaptability of the device during use is improved, and the device is suitable for popularization and application. The outer sides of the limbs of a patient are heated in a wrapping mode through the tin foil thermal insulation covers, blood vessels are expanded easily through hot compress before dialysis, the blood flow can be increased, the limbs of the patient are exposed to medical staff for puncture operation through the adjusted tin foil thermal insulation covers, the use convenience of the device is improved, and the device is suitable for popularization and application. The function of synchronously heating, preserving heat and positioning the limbs of the patient is realized.

A method of treating vaginal tissue atrophy in a female subject, the method including the steps of engaging an energy delivery element with tissue in or around the subject's vagina; applying energy to the tissue from the energy delivery element; and increasing blood flow to internal vaginal tissue to an increased level above a baseline level of blood flow to the internal vaginal tissue, the increased level of blood flow to the internal vaginal tissue persisting after the applying step ceases. The invention also provides devices for performing this therapy.

There is provided in accordance with an exemplary embodiment of the invention a method and / or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and / or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and / or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and / or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.

Disclosed embodiments relate to apparatuses and methods for applying negative pressure to a tissue site or skin site to prepare for a surgical operation. The apparatuses and methods can be used to increase blood flow at or near the tissue site. Therapeutic gas can also be applied to prepare the tissue site for the operation. Antimicrobial and antiseptic agents can also be applied to reduce the bioburden at the tissue site.