23 results about "Vascular dilatation" patented technology

The invention relates to a composition for fading acne marks and application thereof. The composition for fading acne marks comprises PDRN, a lactobacillus / algae extract fermentation product and a fig fruit extract. The acne mark fading composition disclosed by the invention has a synergistic interaction effect, and can efficiently inhibit release of inflammatory factors and fade red marks caused by vasodilatation from the source; the traditional Chinese medicine composition has the advantages that melanin generation can be more synchronously intervened, black marks caused by pigmentation can be effectively prevented and improved, red acne marks and black acne marks can be simultaneously improved through multiple channels by the synergistic mechanism, and the traditional Chinese medicine composition is mild and non-irritant and is more suitable for improving mixed acne marks.

The present invention discloses a cardiovascular intervention device, which belongs to the technical field of cardiovascular surgical instruments. The puncture catheter is pre-filled with liquid medicine. As the air pump inputs gas, the mesh stent is stretched and the contracted blood vessel position is expanded. As the air pump continues to inflate, the piston head extends the pointed part from the inflation port of the puncture catheter, punctures the end of the airbag, and the liquid medicine inside the airbag flows out and diffuses at the vascular surgical site. This device can be used to quickly diffuse immediate-acting drugs such as blood vessel recovery and inhibition of endothelial hyperplasia at the surgical site while performing cardiovascular dilation surgery. Compared with applying the drug directly to the mesh stent, this device can input more liquid medicine at one time, and the amount of liquid medicine is controllable. When the liquid medicine reaches the surgical site, it will not be consumed in other positions of the blood vessel, which is more conducive to the treatment of the patient's vascular surgical site. This intervention device is simple to operate, does not affect the progress of the dilation surgery, and has a better treatment effect.

The invention provides an intelligent integrated balloon catheter system integrating guide wire guiding and blood vessel dilatation, and the intelligent integrated balloon catheter system integrating guide wire guiding and blood vessel dilatation comprises a guide wire guiding mechanism, a blood vessel dilatation mechanism and a balloon dilatation mechanism which are integrally arranged, the balloon dilatation mechanism comprises a balloon and a sheathing canal, the balloon and the sheathing canal are arranged in a penetrating mode, and the balloon comprises a first cavity and a second cavity; a miniature pressure sensor is arranged on the portion, between the balloon and the head end of the sheath tube, of the sheath tube. According to the technical scheme, the balloon solves the problem of early intervention of bleeding in a complex junction region in a pre-hospital and pre-operation waiting stage, and the aim of effectively blocking the bleeding stopping time to be prolonged to more than 90 minutes is achieved.

The invention discloses a coronary medicine balloon dilatation catheter, and belongs to the technical field of medical instruments. In order to solve the problems that an existing drug balloon is high in blood flow blocking risk, large in drug loss and uneven in drug distribution, the balloon dilatation catheter comprises a catheter body, a dilatation balloon, a drug delivery catheter, a drug storage bin, a driving connecting rod, a connecting ring and a guiding head. The dosing catheter protrudes out of the periphery of the dilatation balloon at intervals, the flexible side wall of the medicine storage bin communicates with the liquid injection cavity channel, and the driving connecting rod drives the dosing catheter to rotationally apply medicine through spiral transmission; the catheter body is provided with an independent blood flow cavity channel and a blood inlet, and a gap formed by the catheter body and the administration catheter forms a double-channel blood flow path. The invention realizes the synergy of vasodilatation, accurate and uniform administration and continuous blood perfusion, reduces drug loss and non-targeted deposition, reduces myocardial ischemia complications and postoperative restenosis risk, is simple and convenient to operate, and is suitable for various coronary heart disease treatment scenes.

The invention discloses targeted prebiotic plant extraction dietary powder for conditioning hypertension and a preparation method thereof. According to the present invention, the lactobacillus plantarum CECT5716, the bifidobacterium lactis BLa80 and other strains selected in the formula can regulate the renin-angiotensin system balance by inhibiting the activity of the angiotensin converting enzyme so as to reduce the vasosystolic pressure from the neuroendocrine level; hawthorn flavone and pueraria isoflavone directly act on blood vessels to expand peripheral arteries, improve coronary artery blood flow and enhance blood vessel elasticity; the gamma-aminobutyric acid serving as a neurotransmitter can relieve sympathetic nerve hyperexcitation and reduce blood pressure fluctuation caused by emotion or pressure. Meanwhile, prebiotics such as resistant dextrin provide nutrients for probiotics, promote generation of intestinal short-chain fatty acids, activate a vascular endothelium protection pathway through an intestinal-metabolic axis, form a triple antihypertensive network of strain regulation, plant intervention and flora synergy, and cover different pathological links of blood pressure rise.

The utility model discloses a limb pressure sleeve capable of being used for cold and hot compress, which comprises a pressure sleeve body, an air pipe arranged in the pressure sleeve body, a plurality of air bags symmetrically arranged on one side face of the pressure sleeve body, a contact layer arranged on one side face of the pressure sleeve body, a heating film arranged between the contact layer and the pressure sleeve body, and a cable arranged in the pressure sleeve body. A plurality of notches are symmetrically formed in one side face of the contact layer, a storage bag is arranged on one side face of the contact layer and located among the notches, and a second hook-and-loop fastener thorn face is arranged on one side face of the inner wall of the storage bag. The heating film is heated through power supply of the cable, the heating film is a carbon nano tube / TPU composite film, the heating film is started to heat the legs, and heating can enable local blood vessels to expand, increase blood flow, improve the conveying efficiency of oxygen and nutrient substances, accelerate discharge of metabolic waste, reduce blood viscosity and reduce blood flow resistance, so that the legs are protected from being damaged. The pharmaceutical composition is of clinical significance to patients with hyperlipidemia or diabetes mellitus.

Injecting botulinum toxin directly into the clitoris can treat various sexual dysfunctions and improve sexual satisfaction in many women. Without wishing to be bound by this hypothesis, these effects of botulinum toxin may act by, inter alia, increasing arterial blood flow within the clitoris via vasodilation, neovascularization within the clitoris, neurogenesis within the clitoris, changing autonomic tone, and activating the mid-hypothalamus.

This invention discloses a balloon dilation catheter and vascular dilation device. The balloon dilation catheter includes an inner tube, an outer tube, a catheter seat, and a balloon. A guide wire is inserted into the inner tube. The outer tube is fitted onto the inner tube. The catheter seat has a first inlet and a second inlet, with the first inlet communicating with the inner tube and the second inlet communicating with the outer tube. A plurality of balloons are provided, each balloon sequentially fitted onto the inner tube, with the interior of the balloon communicating with the outer tube. First grooves are evenly distributed on the side of the balloon. In use, the balloon dilation catheter provided by this invention allows a medium to be introduced into the balloon through a second interface to inflate the balloon. The flat portion of the balloon adjacent to the first groove forms the occipital region, and the contact between adjacent balloons forms the second groove. The occipital region applies pressure to the lesion site for dilation, while the evenly distributed first and second grooves buffer the stress experienced during vascular dilation, reducing vascular damage and dissection while ensuring the safety of patient treatment.

The utility model discloses an extracorporeal circulation puncture suite which comprises a dilator, a puncture accessory and a suture accessory, and the dilator used for blood vessel dilation, the puncture accessory used for puncture and the suture accessory used for fixing a pipeline are sealed in a packaging bag body after being sterilized through ethylene oxide. The dilator is provided with dilation heads for dilating blood vessels continuously in a staged mode, and the number of the dilation heads on the dilator can be adjusted. The extracorporeal circulation puncture kit has the advantages that the multi-stage dilator with the adjustable dilation head in the extracorporeal circulation puncture kit is used for performing staged continuous dilation on blood vessels, repeated replacement of the dilator is avoided, the risk of infection of a patient is reduced while the operation efficiency is improved, and due to the staged continuous dilation, intubation tubes of different specifications are high in universality and high in practicability. Due to the design that the hydrophilic coating and the hardening material are additionally arranged on the guide wire, the surface of the guide wire is smoother, puncture catheterization is smoother and more accurate, due to the arrangement of the suture accessory, the problems of intubation fixing and skin wound suture are solved in a clinical one-stop mode, and the preparation workload of clinical operations is reduced.

The invention relates to the technical field of medical apparatus and instruments, and discloses an intelligent debris capturing and blood flow maintaining device for coronary artery rotary atherectomy, which comprises a capturing mechanism and a guide wire, and is characterized in that a capturing assembly is positioned outside the guide wire, a rotary atherectomy catheter is sleeved outside the guide wire, a rotary atherectomy head is mounted at one end of the rotary atherectomy catheter, and the other end of the rotary atherectomy catheter is provided with a blood flow maintaining device. The rotary grinding head is arranged outside the guide wire in a sleeving mode, a blood vessel expansion mechanism is arranged on the outer side of the rotary grinding head, the capturing mechanism comprises a capturing bin, a plug disc is fixedly connected to one end of the capturing bin, and a supporting frame is fixedly connected to the interior of the capturing bin. The semi-permeable membrane and a special structure are used for capturing debris, the arc-shaped plate is matched for expanding blood vessels, smooth blood flow is guaranteed, after an operation is finished, the device and most debris can be taken out by pulling the guide wire, a small amount of missed debris can be swallowed by macrophages or enter a capturing bin to be collected, compared with traditional negative pressure adsorption, a large amount of blood is prevented from being lost, and the operation safety is improved; the postoperative recovery of the patient is facilitated.

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

A balloon catheter and balloon system particularly useful with drug-coated balloons is described. In some embodiments, the balloon catheter system includes various features designed to address problems with drug rubbing off due to contract friction during delivery of the balloon—including by utilizing a protective sleeve to shield the drug-coated balloon. In some embodiments, the balloon catheter system includes an inner high-pressure balloon and an outer drug-coated balloon to mitigate the time associated with performing vessel dilation.

The utility model discloses a cardiovascular dilatation device, relates to medical equipment technical field, including connecting tube, balloon, support wire and connector, said connecting tube is inserted with the trachea, said trachea one end extends out of connecting tube, said connecting tube outside is fixedly connected with the fixed ring, said fixed ring one side is provided with balloon, said connecting tube one side is provided with the support wire, said connecting tube one side is provided with the support wire. One end of the air bag is glued with the fixing ring, the interior of the air bag is communicated with the trachea, the other end of the air bag is provided with the movable ring, and sufficient space between the supporting wires ensures that the interior of the blood vessel keeps a good circulation rate; in addition, the air bag is designed to be in a corrugated pipe shape and only stretches out and draws back during inflation, resistance to the interior of the blood vessel is greatly reduced, operation of the device in the blood vessel is safer and more effective through the design, and meanwhile the risk of damage to the inner wall of the blood vessel is reduced.

The utility model provides a medicine balloon and a blood vessel dilatation device using the same. The medicine balloon comprises an outer balloon and a dilatation balloon arranged in the outer balloon. The expansion bag comprises a plurality of leaf separating bags with windmill leaf-shaped structures; a plurality of leaf separating bags with windmill leaf-shaped structures form a gap channel during expansion, and blood circulation is allowed to be maintained in the expansion process, so that the ischemia risk of the far-end tissue of a target blood vessel is reduced; the method is particularly important for complex lesions needing long-time expansion; and the occurrence of related complications can be reduced. Meanwhile, due to the multi-leaf structure of the leaf-dividing bag, the leaf-dividing bag of the windmill leaf-shaped structure can fully expand the narrow part; the treatment efficiency and the success rate are improved; the innovative dilation equipment is not only suitable for treatment of common vascular stenosis, but also has important application value for special requirements of drug balloon dilation treatment and the like.

The application belongs to the technical field of drug research and development, and particularly relates to a compound, a preparation method and application of the compound as an agonist of orphan receptor GPR99. The application first discovers and identifies a small-molecule compound capable of specifically activating the orphan receptor GPR99, and systematically clarifies the mechanism of the small-molecule compound in the regulation of vascular smooth muscle cell (VSMC) contraction and the improvement of pathological vascular dilation. The discovery not only fills the blank of GPR99 agonists in the field of treatment of rosacea, but also provides a new molecular target and a drug research and development direction for precise treatment of diseases related to abnormal vascular function.

A rehabilitation training wrist developer belongs to the field of rehabilitation training instruments. Comprising an elastic rubber airbag; the outer circular surface of the elastic rubber air bag is fixedly connected with a finger ring, and the outer circular surface of the elastic rubber air bag is also fixedly connected with a fixing seat for fixing a thumb; the fixed seat is arc-shaped, and an arc-shaped groove and a groove communicated with the arc-shaped groove are formed in the inner circular surface of the fixed seat; pressing air bags are fixedly connected into the arc-shaped grooves and the grooves; the end, located in the arc-shaped groove, of the pressing air bag is fixedly connected to the outer circle face of the elastic rubber air bag, and a through hole communicating the pressing air bag with the elastic rubber air bag is formed in the outer circle face of the elastic rubber air bag. The elastic rubber air bag is used for replacing a traditional body-building hand-muscle developer, inflammation aggravation or secondary injury induction caused by excessive friction between tendons and tendon sheaths is avoided, meanwhile, the functions of pressing the thumb of a patient and stimulating vasodilatation are achieved, blood circulation is promoted, metabolic waste discharge is accelerated, swelling and stiffness are relieved, and the body-building effect is achieved. The muscle tension can be relieved.

The invention discloses a tuna blood-source active peptide with ACE inhibitory activity and application thereof, and relates to the technical field of biology. The tuna blood-source active peptide with ACE inhibitory activity is obtained through screening, the tuna blood-source active peptide is composed of five amino acids, the sequence of the tuna blood-source active peptide is DYFMR, the molecular weight of the tuna blood-source active peptide is 730.81 Da, and the tuna blood-source active peptide can effectively inhibit the ACE activity, can adapt to environmental changes and has high bioavailability and good biological safety. The action mode of the tuna blood-source active peptide is mainly through stable combination of a hydrogen bond and ACE protein, and cell experiments prove that the tuna blood-source active peptide prevents conversion from Ang I to Ang II, reduces generation of angiotensin factors and improves release of vasodilatation factors. The tuna blood-source active peptide has the potential of being developed into antihypertensive drugs and products beneficial to maintaining the blood pressure health level, and has high market application value.

The invention discloses an internal arteriovenous fistula vascular dilator which comprises a telescopic band, a first pressure measuring knob, two sliding grooves, two fixing assemblies, a second pressure measuring knob, a third pressure measuring knob and three pressure gages. Connecting structures matched with each other are arranged at the two ends of the telescopic band and used for surrounding and fixing the telescopic band to the arms of the patient, and the tightness of the telescopic band is changed by adjusting the connecting positions of the connecting structures so as to adapt to the thicknesses of the arms of different patients. Therefore, the three pressure measuring knobs with the pressure gauges are arranged, the pressure can be accurately regulated and controlled, the blood vessel pressing accuracy is improved, blood vessel dilation is promoted, other vein blood vessels can be prevented from being pressed, complications are reduced, meanwhile, the fixing assemblies can slide in the sliding grooves, the related knobs are driven to flexibly adjust the positions, accurate adjustment can be achieved according to the blood vessel position difference of a patient, and the operation is convenient. And the universality and the applicability are improved.

The invention belongs to the technical field of medicine research and development, and particularly relates to a compound, a preparation method and application of the compound as an orphan receptor GPR99 agonist. The small molecule compound capable of specifically activating the orphan receptor GPR99 is found and identified for the first time, and the action mechanism of the small molecule compound in vascular smooth muscle cell (VSMC) contraction regulation and pathological vasodilation improvement is systematically clarified. The discovery not only fills the blank of the GPR99 agonist in the field of acne rosacea treatment, but also provides a new molecular target and a medicine research and development direction for precise treatment of vascular dysfunction related diseases.

The invention relates to the technical field of pulmonary arterial hypertension treatment, and discloses an application of a fat factor Chemerin inhibitor in preparation of drugs for treating pulmonary arterial hypertension, the Chemerin inhibitor improves pulmonary vascular remodeling, reduces pulmonary vascular resistance and alleviates right ventricular hypertrophy by inhibiting the activity of Chemerin protein or its receptor CMKLR1; the invention focuses on the key effect of the fat factor Chemerin and the receptor CMKLR1 thereof in pulmonary arterial hypertension, directly blocks the signal channel through the specific inhibitor, inhibits abnormal remodeling of pulmonary blood vessels from the source, reduces vascular resistance and right heart load, overcomes the limitation that the existing vasodilatation drugs cannot reverse vascular structure remodeling, and has a good application prospect. A brand new strategy is provided for disease treatment; a high-selectivity small molecule antagonist and a targeted delivery system are adopted, so that the enrichment efficiency of the medicine in the lung is remarkably improved, and the off-target risk is reduced; aiming at pulmonary arterial hypertension crowds carrying BMPR2 gene mutation or specific imaging characteristics, individualized solutions are provided for patients in different disease course stages.

The polypeptide feed is prepared from the following raw materials in percentage by mass: 35%-40% of a plant crude extract, 35%-45% of a protein source, 5%-8% of microbial flora and 15%-20% of a fermentation auxiliary material, wherein the plant extract is prepared from the following raw materials in percentage by mass: 50% of an astragalus membranaceus crude extract, 30% of a codonopsis pilosula crude extract and 20% of an angelica sinensis crude extract. The feed contains various plant and animal-derived amino acids, can supplement various nutrients in animal bodies, maintain amino acid balance, and is beneficial to enhancing protein fat absorption, promoting muscle and fat growth and improving meat quality and flavor, and meanwhile, the rich peptide contains various beneficial bacteria and free fatty acids, so that vasoactive intestinal peptide causes vasodilatation of mesentery, and the meat quality and flavor are improved. Protease and digestive enzymes are secreted in quantity, intestinal tract movement is enhanced, digestive absorption and anabolism of the body are enhanced, and therefore growth of the body is promoted.

An integrated apparatus for vascular dilation and aneurysm coil delivery, comprising a catheter (1) and a deformable balloon (2). The catheter (1) is connected to a proximal end of the balloon (2). At least three channels are arranged in the catheter (1): a balloon inflation channel (101), a guide channel (103), and a coil channel (102). The balloon inflation channel (101) is in communication with an inner cavity of the balloon (2) so as to inject the balloon (2) with a contrast agent to expand the balloon (2). The guide channel (103) penetrates through the inner cavity of the balloon (2) from the proximal end of the balloon (2) and out of a distal end of the balloon (2) and is configured for sleeving a micro-guide wire (4) or delivering a stent. The coil channel (102) penetrates through the inner cavity of the balloon (2) from the proximal end of the balloon (2) and out of a side wall of the balloon (2). A coil (3) is arranged in the coil channel (102) in a penetrating manner for delivery of the coil (3). The integrated apparatus is beneficial to efficient, accurate, and stable delivery of the coil and the stent and vascular dilation, thereby reducing the surgical risk.

Provided in the present description are a vascular projection visualization method and apparatus, and a storage medium and an electronic device. The method comprises: acquiring a first image of a target region by computed tomography angiography and a second image of the target region by digital subtraction angiography; determining a vascular path and a plaque region in the first image, and constructing a mesh structure of the vascular path; on the basis of a positional relationship between the mesh structure and the plaque region in the first image, obtaining an occlusion relationship between the mesh structure and the plaque region; and on the basis of the occlusion relationship, rendering a mesh structure and the plaque region in the second image, so as to obtain a fused image. A mesh structure of a vascular path is constructed, and on the basis of an occlusion relationship between the mesh structure and a plaque region, the mesh structure and the plaque region are rendered in a second image to obtain a fused image, such that a positional relationship between the mesh structure and the plaque region in a mapping direction of the second image is intuitively reflected while the degree of vascular stenosis, the degree of vascular dilation, and the location of a plaque are displayed.