93 results about "Great Blood Vessel" patented technology

A system, method and computer program product is provided for analyzing spectral images of a micrcirculatory system to measure the volume and concentration of a blood vessel. The images are analyzed to identify vessel structure, measure the light absorption and develop a contrast gradient plus (KGP) estimate. The KGP estimate is used to predict blood characteristics, such as hemoglobin concentration and hematocrit. The KGP is estimated in three distinct phases. First, the images are screened to measure a mean image intensity and motion blur. Second, each image is analyzed to identify background curvate, and create vessel, background and diameter masks. To identify background curvate, the images are analyzed to detect shadows caused by larger blood vessels in the background image. The diameter and area of the vessels are also calculated. During the Prediction and Calibration phase, the images are screened to eliminate all images failing thresholds for mean intensity, motion blur, background curvature and area-to-perimeter ratio. Finally, the KGP estimate is determined from the selected images.

Provided is a stroke diagnosis apparatus based on AI that includes: an image obtainer obtaining a non-contrast CT image related to the brain of at least one patient; a preprocessor pre-processing the non-contrast CT image and determining whether the at least one patient is in a non-hemorrhage state or a hemorrhage state on the basis of the pre-processed image; an image processor normalizing the pre-processed image and dividing and extracting an ROI (Region of Interest) using a preset standard mask template; and a determiner determining whether there is a problem with a cerebral large vessel of the at least one patient using the divided and extracted ROI.

The invention discloses an OCTA imaging method and device based on two-dimensional composite registration. The invention discloses a two-dimensional composite registration method, a plurality of preliminary blood flow contrast images are used; after an OCTA effective strip is extracted, a global registration method based on large vessel skeleton registration degree and SIFT feature point extraction and a local registration method based on SIFT flow target function detection are used in a combined mode to perform registration on the OCTA effective strip pair on the two-dimensional level, and then motion artifacts are eliminated. The obtained fused OCTA result image is small in pixel average error, good in quality and high in structural similarity with an original OCTA blood flow contrast image, motion artifacts contained in the fused OCTA result image are greatly reduced and even disappear, and high-quality OCTA blood flow contrast imaging is achieved.

The invention discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof, particularly discloses application of a beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing and treating diabetes mellitus and chronic complication thereof, and belongs to the technical field of medicines. A diabetes rat model is induced with streptozotocin (STZ); the prevention and treatment effects of the beta-hydroxybutyric acid on diabetes and chronic complication of rats are observed with the beta-hydroxybutyric acid through subcutaneous injection; the result shows that the weight loss of the rats can be restrained by the beta-hydroxybutyric acid; the pathology function change of chronic pancreas, great vessels, kidneys, hearts, livers and the like of the rats is improved; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof as an active pharmaceutical ingredient is combined with conventional additives in the field of medicines to prepare medicines; the beta-hydroxybutyric acid or the pharmaceutically acceptable salt thereof can be used for improving the diabetes and the chronic complication thereof; and clinical treatment is carried out by aiming at diseases caused by anti-oxidative stress and nitration injuries.

The invention discloses a preparation cryopreservation method of the human placental subchorionic villi aorta tissue. The method comprises the steps that (1) a placenta is washed cleanly; the abscisicdecidua is cut off along the edge of the placenta, and the amniotic membrane is removed; (2) the placenta fetal surface chorion with the amniotic membrane and the aortas are separated and washed withnormal saline or PBS buffer liquid, the blood vessels are washed so as to remove the stranded blood clots in the blood vessels; and then, the aortas connected with the chorion lamina membranacea is cut off one by one; and (3) the blood vessels are transferred into a cryopreserved pipe or a cryopreserved bag, vitrified cryopreservation liquid is guided through a three-step method, the blood vessels are transferred into a programmed freezer so as to be cooled at -80 - -90 DEG C, and then the blood vessels are transferred to liquid nitrogen cryopreservation. The cryopreservation method is beneficial for improvement of the activity of the cryopreserved tissue and the cells, the morphology, the function and the structure are consistent with the fresh tissue after being recovered, the preservedtissue can not only be applied to fields of separation of stem cells and epithelial cells, but also can be applied to fields of tissue engineering transplantation.

A catheter tip for guiding the catheter through a patient's blood vessels and keeping the catheter in large vessels and preventing entry into smaller branch vessels.

Methods and devices are provided for protecting the cerebrovascular circulation from embolic debris released during an index procedure. An embolic protection filter is delivered in a reduced profile configuration via an access catheter, and positioned in the aorta spanning the ostia to the three great vessels leading to the cerebral circulation. An index procedure catheter is thereafter advanced through the same access catheter to conduct the index procedure. The index procedure may be a transcatheter aortic valve replacement.

The invention discloses an establishment method of an improved allogeneic vein transplantation model in rats. The establishment method of the improved allogeneic vein transplantation model in rats comprises the following steps: carrying out field preparation of anesthetics, weighing a rat, and carrying out intraperitoneal injection of the anesthetics at certain amount according to the weight of the rat so as to have the rat anesthetized; putting the anesthetized rat onto a temperature-controlled blanket, and fixing the rat on an operation table; ensuring that the body of the rat is straight and tension-free, shaving off hairs on the chest of the rat by using a shaver, and carrying out local disinfection by using Anerdian (a skin disinfectant); making an anterior incision, of which the length is about 3cm, on the right sternocleidomastoid muscle of the rat so as to have the skin and the subcutaneous tissue cut open; and then, separating out the superior vena cava in the rat, cutting offthe distal end of the superior vena cava, and flushing the venous lumen by using heparin saline of which the concentration is 5000 U/L. The establishment method of the improved allogeneic vein transplantation model in rats allows direct contact of the inner walls of the artery and the vein, so that relatively large anastomosis area is ensured so as to prevent the blood vessels from necrosis; andmoreover, the vascular cuff does not contact with the blood, and the vascular bridge is completely the vein after the transplantation, so that there is no risk of vascular blockage. Therefore, successrate of vein allografts in rats is improved; and mechanism of clinical vascular transplantation is better met.

The invention relates to the technical field of clinical medical treatment, and discloses a tissue biopsy needle. The tissue biopsy needle comprises a power mechanism, an outer sleeve needle and an inner core needle, wherein the inner core needle is embedded in the outer sleeve needle, a groove is formed in the side wall of the tail end of the outer sleeve needle, a semi-ring cutter correspondingto the groove is arranged on the inner core needle, and the power mechanism drives the semi-ring cutter to transversely rotate in the outer sleeve needle through a needle rod. The tissue biopsy needlehas the beneficial effects that in the process that a cutter opening of the inner core needle and a side cutter act together to cut tissue, the power mechanism drives the semi-ring cutter to rotate rapidly through the needle rod, rapid rotary cutting of the tissue to be detected is achieved to form a complete cylindrical sample, and the tissue is convenient to detect. In the cutting process, dueto the fact that rotary cutting is adopted, the outer sleeve needle and a needle tip are static, shaking cannot occur, damage to surrounding important organs is avoided, safety is greatly improved, and biopsy can be conveniently carried out on tissue such as large vascular gaps, dangerous organ sides, small nodules and lymph nodes.

Disclosed is a thyrocricocentesis needle. The thyrocricocentesis needle comprises a deep vein puncture needle, the tail end of the deep vein puncture needle is connected with a needle tube, the inside of the needle tube is provided with a piston and a push rod, the inside of the needle tube between the piston and the deep vein puncture needle is provided with a spring, and the portion of the deep vein puncture needle, which is closed to the needle tube, is provided with a valve; one end of the push rod is connected with the piston, and the other end of the push rod is provided with a handle. The thyrocricocentesis needle can ensure that the needle punctures a trachea, and is easy to operate, accurate in location, safe and practical. Besides, the thyrocricocentesis needle can reduce the risks of mis-puncturing an esophagus or a great vessel as well as the operating difficulty of a doctor holding the needle in a negative-pressure mode in inserting the needle, so that the doctor can more concentrate on judgment of anatomic layers to avoid the risk of mis-puncture.

Methods and devices are provided for protecting the cerebrovascular circulation from embolic debris released during an index procedure. An embolic protection filter is delivered in a reduced profile configuration via an access catheter, and positioned in the aorta spanning the ostia to the three great vessels leading to the cerebral circulation. An index procedure catheter is thereafter advanced through the same access catheter to conduct the index procedure. The index procedure may be a transcatheter aortic valve replacement. A pore distribution in the filter blocks passage of debris greater than a predetermined threshold, minimizes total cumulative volume of debris passing through the filter and minimizes blood pressure drop across the filter.

The invention relates to an application of F-box/WD40domain protein 7 (FBXW7) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the FBXW7 obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the FBXW7 protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the FBXW7 can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that FBXW7 or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, ortreating diabetes, or preventing and treating diabetic complications, or for preventing and treating tumorigenesis of diabetic individuals.

The invention discloses a preparation and cryopreservation method of human placental chorionic tissues. The method comprises the following steps: (1) cleaning a placenta, and cutting off a shed decidua along the edge of the placenta to remove the amnion; and (2) separating the amnion-removed placenta fetus chorion and large vessels to obtain remaining placenta tissues which are placental chorionictissues, cutting the placental chorionic tissues to form small blocks, cutting the small blocks to form slices, placing the slices in a cryopreservation bag or a cryopreservation tube, guiding a vitrification cryopreservation solution through a three-step process, transferring the obtained mixture into a programmable cooler, reducing the pressure to -80 to -90 DEG C, transferring the cooled mixture to liquid nitrogen, and performing cryopreservation. The cryopreservation method facilitates the improvement of the activity of cryopreserved tissues and cells, the morphology, the function and thestructure of resuscitated cryopreserved tissues are same to those of fresh tissues, the overall survival rate of cells in the tissues reaches 90% or above, and the preserved tissues can be used in the field of separation of stem cells and epithelial cells, and also can be used in the field of tissue engineering transplantation.

The invention discloses a rapid hemostat suitable for war wound massive hemorrhage, and relates to the technical field of medical instruments; the rapid hemostat comprises an injection mechanism and ahemostatic material, wherein the injection mechanism comprises an injection cylinder, a piston, an injection cylinder front cover and a percussion assembly; the hemostatic material is composed of barium sulfate powder with a diameter of less than 2 [mu] m, chitosan particles with a high deacetylation degree (greater than 90%) and a diameter of 2 mm, and prothrombin powder. The chitosan particlesin the hemostatic material rapidly expand to press a bleeding point, prothrombin is combined to promote fibrinogen to be converted into fibrin solidified blood to achieve the purpose of rapid hemostasis; and the chitosan particles are filled with barium sulfate powder which can be developed under X-ray radiography, so that identification and thorough taking of rear hospitals are facilitated. The rapid hemostat has the advantages of being simple, safe, economical and practical, is suitable for bleeding which is not prone to compression control and is caused by trauma of a body joint area and ajunction area and damage to large blood vessels, and is exact in hemostasis effect and high in hemostasis speed.

The invention provides an intubation propelling device suitable for great vessel surgery, and relates to the technical field of medical equipment. A cannula propelling device suitable for great vessel surgery comprises a hollow outer shell, a first opening and a second opening which are oppositely arranged are formed in the side wall of the outer shell, and a pressing assembly and a pushing assembly are arranged in the outer shell; the pressing assembly is arranged above the pushing assembly, the pushing assembly comprises an annular pushing belt and a driving assembly used for driving the pushing belt to rotate, the driving assembly is arranged on the outer shell, and the pushing belt is in transmission connection with the driving assembly; the top of the pushing belt is horizontally arranged and located below the pressing assembly. By the adoption of the intubation propelling device, the catheter can be pushed into a human body slowly and stably, and the surgical risk is reduced.

The invention discloses a device for segmenting lung blood vessels from a lung mask image. The device comprises a calculation module, an image acquisition module, an image fusion module, a blood vessel segmentation module, a blood vessel position determination module and a blood vessel edge optimization module. The calculation module and the image acquisition module are in mutual electric signal connection, the image acquisition module is used for acquiring an image of a lung mask, the calculation module is used for calculating a range of a blood vessel size in the lung mask image, and the image acquisition module and the image fusion module are in mutual electric signal connection. And the image fusion module is used for carrying out image fusion on the plurality of lung mask images to obtain a fused lung fusion image. The method has the advantages that the gray scale distribution of small blood vessels is uniform, the gray scale contrast between the blood vessels and surrounding tissues is obvious, the obvious gray scale difference boundary is provided, the accuracy of pulmonary blood vessel extraction is improved, the gray scale value difference between the blood vessels and other tissues such as adjacent bones and ventricular blood in the image is large, and the blood vessel segmentation image is accurate and clear.

The invention belongs to the technical field of medical instruments, and particularly relates to a hemostatic stent for cardiac macrovascular surgery. The hemostatic stent comprises a sleeve; a pipe head and a pipe tail are arranged at the two ends of the sleeve respectively, the end, away from the sleeve, of the pipe head is in smooth transition and closed, and the pipe tail is in threaded connection with the sleeve; an annular elastic bag is arranged on the periphery of the sleeve, and the elastic bag communicates with an air inlet pipe arranged in the sleeve in the axial direction of the sleeve; the end, away from the elastic bag, of the air inlet pipe communicates with a detachable air tank, and compressed air is contained in the air tank; and the middle of the air inlet pipe communicates with a sliding hole formed in the diameter direction of the sleeve, a sliding column is slidably connected into the sliding hole, a first valve hole is formed in the sliding column, and a circularbead is arranged at an end a, extending out of the sleeve, of the sliding column. By pressing the end a of the sliding column, the built-in air tank can be opened to inflate the elastic bag, hemostasis is achieved after the elastic bag is expanded, connection of the hemostasis stent to excessive pipelines is reduced, and the hemostasis efficiency is improved.