25 results about "Contrast imaging" patented technology

This invention discloses a beam expander lens for laser scanning projection, relating to the field of laser projection display technology. It includes a first lens group, a second lens group, a third lens group, and a fourth lens group, arranged sequentially along the optical axis. These four lens groups together form the complete lens. The first, second, third, and fourth lens groups are arranged in a positive-negative-negative-negative optical power configuration. Through innovative optical architecture and optical power allocation, a large-angle beam expander function is achieved within a space of less than 35mm in total length, greatly saving internal space. By utilizing the chromatic aberration correction capability of the first lens group and the aberration correction capabilities of the second, third, and fourth lens groups, high-contrast imaging is achieved across the entire field of view and wavelength range, with concentrated dot matrix energy, meeting the requirements of high-resolution projection.

This invention discloses a low-pass filtered non-breath-hold saline angiography combined with cardiac mirror contrast imaging for lung perfusion imaging, belonging to the field of medical imaging technology. The method includes the following steps: S1: determining whether the subject's tidal impedance variation meets the imaging criteria; S2: injecting contrast agent into the subject to perform angiography; S3: obtaining an impedance decrease signal; S4: combining cardiac mirror contrast imaging with lung perfusion images. This invention solves the problem of low success rate of saline angiography in existing technologies, achieves separation of thoracic impedance caused by tidal breathing and thoracic impedance caused by saline angiography, reduces the influence of the cardiac region on lung perfusion images, further improves the accuracy of lung perfusion imaging, greatly reduces the interference of breath-holding on respiratory circulation, improves the simplicity of clinical application, and expands clinical application scenarios.

This application relates to the field of image information processing technology and provides a fusion contrast imaging method, a registration method and apparatus for intracavitary images and contrast images. The fusion contrast imaging method includes: acquiring contrast images and intracavitary images; fusing the contrast images and intracavitary images based on the correspondence between contrast markers and intracavitary markers to obtain a fusion contrast imaging result. This application links contrast images and intracavitary images through contrast markers and intracavitary markers, enabling intracavitary image information and contrast image information to correspond and be fused to obtain a fusion contrast imaging result, thereby overcoming the problem that traditional contrast images contain only a single type of information.

A system for analyzing biological components in a biological sample, wherein the system comprises a planar surface, and wherein the system is configured to perform a procedure comprising: (a) arranging a spatially connected biological sample adjacent to the planar surface, wherein: the spatially connected biological sample comprises a tissue sample, the tissue sample comprises a plurality of cells, the planar surface comprises glass, plastic, or a combination thereof, the planar surface further comprises a plurality of binding sites, the plurality of binding sites is arranged in a two-dimensional pattern on the planar surface, the planar surface comprises at least 10⁵ binding sites, each of the plurality of binding sites comprises a plurality of single-stranded oligonucleotides, and the plurality of single-stranded oligonucleotides is coupled to the planar surface.at least one subset of the plurality of single-stranded oligonucleotides comprises: (i) a binding sequence comprising a plurality of thymine bases configured to bind to poly-A sequences, (ii) a unique molecular identifier, (iii) a barcode associated with a position on the planar surface, and (iv) a sequencing primer, and each oligonucleotide of the subset of the plurality of single-stranded oligonucleotides comprises at least 50 nucleotides; (b) imaging at least a portion of the spatially linked biological sample, wherein the imaging comprises bright-field imaging, phase-contrast imaging, fluorescence imaging, or a combination thereof; (c) releasing nucleic acids from the spatially linked biological sample; and (d) capturing at least one subset of the nucleic acids on at least the subset of single-stranded oligonucleotides, thereby recovering the captured nucleic acids.the captured nucleic acids are immobilized on the flat surface.

This invention provides a method for charged particle beam (CPB) phase contrast imaging. [Solution] In a CPB system, the phase contrast image is obtained by directing a sample-modulated CPB to the phase plate so that it has a diffraction plane displaced from the phase plate. Based on the interference fringes of the image, the lateral displacement of the CPB relative to the phase plate can be estimated and adjusted.

This invention belongs to the field of acoustic detection technology for partial discharge in power equipment, and relates to an array-type acoustic imaging partial discharge detection method and system. The method includes: establishing the correspondence between channel identifier sequences and array geometric parameters; dividing the array into subgroups according to a fixed subgrid and generating a synchronous sampling time sequence to acquire multi-channel pulse density modulation signals; demodulating and extracting the signals, bandpass filtering and pulse framing; constructing a forward-backward spatial smoothing covariance matrix and using minimum variance distortionless response beamforming to calculate the spatial spectrum to generate an acoustic image; and registering and superimposing the acoustic image with a visible light image to output the positioning result. The technical solution of this application achieves high-contrast imaging and stable positioning output through temporal and geometric consistency constraints, which can improve the consistency of on-site interpretation and meet the requirement of repeatable positioning under weak partial discharge ultrasonic conditions.

The application relates to the technical field of medical devices, in particular to a skin ultrasound contrast-based axillary sentinel lymph node puncture guiding method. The core of the method is as follows: after injecting an ultrasound contrast agent with a specific particle size through the skin, a preset low-mechanical-index high-frame-rate double-amplitude contrast imaging mode is adopted to dynamically track lymph drainage and sentinel lymph node development, and the enhancement characteristics are recorded; then, under the guidance of multimodal imaging which is fused with real-time contrast, elastic imaging and color Doppler, the target lymph node is accurately punctured and biopsied, and a tissue sample is obtained for pathological analysis. The application realizes integrated operation from sensitive development of the sentinel lymph node, function evaluation to accurate puncture, and provides a non-radiation high-precision puncture guiding method for accurate evaluation of the axillary lymph node state of breast cancer patients before operation.

This invention relates to the field of high-contrast imaging with optical synthetic aperture, specifically to a method, medium, and device for precise detection of co-phase errors using non-coaxial beam-combining zero-elimination interferometry. This invention directly utilizes the non-coaxial zero-elimination interferometry signal for error inversion, eliminating the need for additional optical components. Furthermore, the algorithm does not require iteration, resulting in a high detection frequency, making it suitable for co-phase applications with high real-time requirements. The co-phase scheme of this invention can simultaneously demodulate tilt and piston errors with high precision using only the zero-elimination interferometry signal without adding additional optical components. This invention also demodulates relative tilt and piston errors using two-dimensional discrete Fourier transform, exhibiting strong anti-noise interference characteristics and making it suitable for co-phase applications with low signal-to-noise ratios.

Disclosed are a method, device, and system for X-ray CT contrast imaging using magnetic nanoparticles. The method includes: rotating a target object containing magnetic nanoparticles as contrast agent for one circle relative to X-rays, recording multiple consecutive transmission projection images of the target object at all angles; for multiple transmission projection images at each angle, after conducting image post-processing operations, performing inverse projection transform on magnetic nanoparticle imaging projection images at all angles to obtain a tomographic imaging result. The image post-processing operation includes: time-frequency transform: converting the third dimension of the three-dimensional time domain matrix to frequency domain to obtain a three-dimensional frequency domain matrix; feature extraction: selecting a two-dimensional matrix with frequency of kf along the third dimension of the three-dimensional frequency domain image matrix; k is a positive integer; f is the frequency of the excitation magnetic field.

Systems and methods for medical contrast imaging are disclosed. Systems and methods of the present disclosure address the challenges of continental medical imaging by, for example, using contrast agents that facilitate use of low-risk wavelengths of imaging radiation, and / or by using imaging methods that facilitate imaging with resolution and / or image quality that are adequate for diagnosis, treatment, and / or any other suitable purpose(s). Examples of suitable wavelengths for the imaging radiation may include certain microwave and / or radio-frequency wavelengths that pose little to no health hazards.

This invention discloses a differential interferometric phase-contrast imaging system, method, and time-difference incubator device, belonging to the fields of optical imaging and medical device technology. The system includes an illumination source module, a microscopic imaging module, a polarization interferometry module, and a quantitative phase image reconstruction module. By placing all polarization interferometry components, such as the polarizer and polarization beam splitter, on the image side of the microscopic imaging module, the imaging beam does not need to pass through the plastic culture dish before passing through the polarization elements, thus completely avoiding interference from plastic birefringence on the imaging and achieving high-quality observation of samples in cell biology or materials science fields within plastic culture dishes. Simultaneously, the system uses a polarization camera to simultaneously acquire multiple phase-shifted interferograms in a single exposure, combined with a quantitative phase reconstruction algorithm, achieving high-speed, high-precision quantitative phase imaging, overcoming the shortcomings of traditional mechanical phase-shifting methods, such as slow speed and susceptibility to motion artifacts. Furthermore, the imaging system of this invention can also be integrated into a time-difference incubator.

This invention discloses an electrically controlled dual-mode imaging liquid crystal lens and its fabrication method, comprising a liquid crystal cell and a liquid crystal mixture within the liquid crystal cell. The liquid crystal mixture includes a liquid crystal matrix, polymerizable liquid crystal monomers, and a photoinitiator. Two liquid crystal lens structures with different imaging functions are formed on the upper and lower inner surfaces of the liquid crystal cell, corresponding to a bright-field imaging mode and a spiral phase-contrast imaging mode, respectively. Each liquid crystal lens structure includes a polymerized region and an unpolymerized region formed by laser selective curing. The orientation of liquid crystal molecules in the polymerized region is fixed, while the orientation of liquid crystal molecules in the unpolymerized region can be changed with the applied voltage. By applying different voltages to the liquid crystal cell, one of the two liquid crystal lens structures is activated while the other is deactivated, achieving electrical switching between the bright-field imaging mode and the spiral phase-contrast imaging mode. This invention achieves rapid electrical switching between bright-field imaging and spiral phase-contrast imaging modes, and combined with femtosecond laser direct writing technology, it enables single-step device fabrication.

The invention relates to an X-ray imaging device (100), said device (100) comprising: - an X-ray source (10) arranged to emit a flux (11) of X-rays towards a sample (1); - an X-ray image detector (30) spaced from said X-ray source (10) at a distance greater than or equal to 80 cm and less than or equal to 1.6 m and arranged to capture the flux (11) of X-rays having passed through said sample (1); - a processing unit (40) configured to determine a phase-shift image, and to reconstruct, from this phase-shift image, a phase-contrast image of said sample, said device (100) having an optical magnification greater than or equal to 8 and less than 20. Figure for the abstract: Fig. 1

The application discloses a kind of high contrast imaging wave front detection and correction method and system, this method uses FPGA and CPU hybrid programming architecture to realize high-precision high contrast imaging wave front detection and correction, locking is realized to high contrast imaging dark area in closed-loop correction, wherein, high-precision wave front slope calculation is completed in FPGA, sub-aperture image division and wave front recovery calculation are realized in CPU, and voltage control deformable mirror correction wave front aberration is output.The application uses hybrid programming architecture to carry out high contrast imaging wave front detection and correction, realizes high-precision wave front detection and correction, solves the problem of insufficient performance of CPU for aerospace, and then realizes the locking of high contrast imaging dark area of space coronagraph, for direct imaging detection of exoplanet.After wave front detection and correction, the energy stability of high contrast imaging dark area can be guaranteed, and dark area locking is completed.

This invention discloses an aberration correction and quantitative phase imaging method based on a physically driven neural field. The method constructs a physical forward model for differential phase-contrast imaging under partially coherent illumination conditions and implicitly represents the sample's complex transmission function and optical aberrations using a neural field. By jointly optimizing sample information and optical aberrations through a differentiable operator, it achieves an inversion solution from intensity information to the sample's phase distribution. This method overcomes the limitations of weak object approximation, achieving self-calibration of optical aberrations and high-precision phase recovery without additional calibration data or acquisition overhead. It is suitable for quantitative phase imaging of biological samples or micro / nanostructured samples.

A system for analyzing biological components in a biological sample, wherein the system comprises a planar surface, and wherein the system is configured to perform a procedure comprising: (a) arranging a spatially connected biological sample adjacent to the planar surface, wherein: the spatially connected biological sample comprises a tissue sample, the tissue sample comprises a plurality of cells, the planar surface comprises glass, plastic, or a combination thereof, the planar surface further comprises a plurality of binding sites, the plurality of binding sites is arranged in a two-dimensional pattern on the planar surface, one of the numerous binding sites has a dimension of about 1 micrometer to about 20 micrometers, each of the numerous binding sites comprises a plurality of single-stranded oligonucleotides, and the plurality of single-stranded oligonucleotides is coupled to the planar surface.wherein at least one subset of the plurality of single-stranded oligonucleotides comprises: (i) a binding sequence comprising a plurality of thymine bases configured to bind to poly-A sequences, (ii) a unique molecular identifier, (iii) a barcode associated with a position on the planar surface, and (iv) a sequencing primer, and each oligonucleotide of the subset of the plurality of single-stranded oligonucleotides comprises at least 50 nucleotides; (b) imaging at least a portion of the spatially linked biological sample, wherein the imaging comprises bright-field imaging, phase-contrast imaging, fluorescence imaging, or a combination thereof; (c) releasing nucleic acids from the spatially linked biological sample; and (d) capturing at least one subset of the nucleic acids on at least the subset of single-stranded oligonucleotides, thereby recovering the captured nucleic acids.the captured nucleic acids are immobilized on the flat surface.

This invention discloses a laser welding device and method for multi-row large battery module connectors. The welding device includes a motion platform and welding components. The motion platform includes a machine base, within which a laser system control system is installed. The laser system control system controls the laser and the overall laser optical path. A Y-axis module slide is installed on the machine base, and a product positioning plate is installed on the Y-axis module. The welding components include a fixed frame, an X-axis module, a Z-axis module, and a welding module. The welding module includes a substrate, which is fixedly mounted on the slider of the Z-axis module. The substrate has multiple sets of mounting threaded holes and mounts a galvanizing head and a depth camera. The depth camera is adjacent to the galvanizing head and separated from it by a light-blocking plate. A ring-shaped surface light source is located directly below the depth camera for high-contrast imaging of the welding position. The substrate is equipped with a separate welding nozzle. This method enables high-speed, integrated, safe welding of multi-row large battery module connectors with a large range of motion, as well as rapid and flexible changeover.

This invention discloses an in-situ observation system and method for lubricating films based on adaptive focusing and fluorescence tracing, belonging to the fields of material performance testing and lubrication technology. The system includes a rotary drive assembly, a high-speed camera, a piezoelectric adaptive focusing system, a fluorescence tracing system, and a processor. The high-speed camera is fixedly mounted on the rotating shaft of the rotary drive assembly and rotates synchronously with the sample. The piezoelectric adaptive focusing system includes a displacement sensor, a displacement compensation module, and a feedback controller, which drives the displacement compensation module to move in the opposite direction in real time based on axial displacement data to compensate for focal plane deviation. The fluorescence tracing system includes an excitation light source and a filter. The processor acquires fluorescence images, extracts dynamic characteristic parameters of the lubricating medium, and calculates the dynamic balance between centrifugal force and capillary force, achieving micron-level stable focusing and high-contrast imaging of extremely thin oil films under high-speed rotation. It can quantitatively invert the equivalent pore size of porous materials, providing direct experimental support for the optimization of self-lubricating materials.

Systems and methods for medical contrast imaging are disclosed. Systems and methods of the present disclosure address the challenges of continental medical Imaging by, for example, using contrast agents that facilitate use of low-risk wavelengths of imaging radiation, and / or by using imaging methods that facilitate imaging with resolution and / or image quality that are adequate for diagnosis, treatment, and / or any other suitable purposefs). Examples of suitable wavelengths for the imaging radiation may include certain microwave and / or radio- frequency wavelengths that pose little to no health hazards.

This invention relates to the field of semiconductor crystal detection technology, specifically a method for detecting dislocations in gallium nitride (GaN) crystals. The method includes: acquiring a set of original contrast images containing crystal orientation contrast distribution information using an electronic channel contrast imaging device; extracting local phase information of pixels using Hilbert transform and constructing a three-dimensional phase field; calculating the phase gradient to form a topological gradient field; identifying various dislocation feature points and constructing a dislocation line connection network; and filtering key dislocation feature points based on dual thresholds. The feature points are then input into a generative adversarial network (GAN) constrained by topological difference and phase continuity constraints, outputting an enhanced dislocation phase field. An enhanced dislocation image is generated through complex fusion, nonlinear dynamic iterative evolution, and wavelet reconstruction. This method can deeply mine hidden phase features in contrast images, accurately distinguish various dislocation structures in the crystal, and completely preserve subtle dislocation morphological details, achieving refined detection and characterization of dislocations in gallium nitride crystals.

This invention relates to the field of image processing technology. Addressing the problem that existing MSR algorithms suffer from image enhancement effects due to changes in the intestinal environment, this invention proposes a method for enhancing ultrasound contrast-enhanced images of nasoenteric tube placement. This method includes: acquiring and preprocessing ultrasound contrast-enhanced image sequences of the nasoenteric tube placement area; highlighting microbubble signal features in the ultrasound contrast-enhanced image sequences; establishing a quantitative correlation between the intestinal physicochemical environment and microbubble signal features; obtaining the expected attenuation level of microbubble signal features under the current environment; dynamically adjusting the core parameters of the MSR algorithm based on the expected attenuation level; constructing an MSR image processing model; and inputting the preprocessed ultrasound contrast-enhanced image sequence into the MSR image processing model for enhancement processing, highlighting the nasoenteric tube structure and achieving precise localization of the distal end of the nasoenteric tube. This invention can significantly improve the contrast between the nasoenteric tube structure and the background, and maintains the stability of image enhancement effects under different intestinal environments.

A surgical robotic system (10) includes a primary imaging source (51) and an auxiliary imaging source (511) disposed within a patient. The primary imaging source (51) is used to image a surgical site and one or more instruments (50, 50') in monochrome near-infrared (NIR) mode. The auxiliary imaging source (51') is used to image the instruments in white mode. A white overlay is extracted from the video feed of the auxiliary imaging source and used to generate a composite image with the NIR video feed (694) so that the instruments (50, 50') are visible in the monochrome video feed (694). The overlay is aligned with the NIR video feed (694) via one or more image processing techniques.

An ultrahigh-resolution contrast imaging method, a blood vessel imaging method and an ultrasonic imaging device, the method comprising: acquiring a plurality of frames of ultrasonic data collected for a target object injected with a contrast agent; performing data processing based on the plurality of frames of ultrasonic data using a first processing technique to obtain a first image, wherein the first processing technique is an imaging technique other than a second processing technique; performing data processing based on the plurality of frames of ultrasonic data using the second processing technique to obtain a second image, wherein the second processing technique is an ultrahigh-resolution contrast imaging technique; and displaying the first image and the second image, wherein the spatial resolution of the second image is higher than that of the first image, and the temporal resolution of the second image is higher than or equal to that of the first image. The ultrahigh-resolution contrast imaging method and device of the present application can improve the readability of blood vessel morphology at different levels and more accurately represent the lesion blood vessel morphology and blood perfusion path.

For boundary detection, such as heart wall detection for strain or another quantification, the boundary is detected using multiple types of imaging, such as B-mode and contrast. The confidence in the detected locations is used to form a more accurate boundary, such as replacing low confidence locations from B-mode imaging with higher confidence locations from the contrast imaging. Even where experts may struggle to identify boundaries, a more accurate boundary is created and used by the image processor or processing.

The application discloses a differential interference phase contrast imaging system and method and a time-difference incubator equipment, and belongs to the technical field of optical imaging and medical instruments. The system comprises an illumination light source module, a microscopic imaging module, a polarization interference module and a quantitative phase image reconstruction module. The polarizer, the polarization beam splitter and other polarization interference components are all arranged on the image side of the microscopic imaging module, so that the imaging light beam does not need to pass through the plastic culture dish before passing through the polarization element, thereby completely avoiding the interference of the plastic birefringence on the imaging, and realizing high-quality observation on the samples in the fields of cell biology or material science in the plastic culture dish. Meanwhile, the system synchronously acquires multiple phase shift interference images by single exposure of the polarization camera, and combines the quantitative phase reconstruction algorithm to realize high-speed and high-precision quantitative phase imaging, and overcome the defects of slow speed and easy motion artifacts of the traditional mechanical phase shift method. In addition, the imaging system can be integrated in the time-difference incubator.