77 results about "Contrast imaging" patented technology

The embodiment of the invention provides a magnetic resonance imaging method and related equipment. The magnetic resonance imaging method comprises the following steps: applying a multi-spin echo sequence in each magnetization reset period, and collecting a group of multi-spin echo data sets until M groups of multi-spin echo data sets are obtained; after each magnetization reset period, a T1rho preparation pulse with spin locking duration is applied, then a multi-gradient echo sequence is applied, a group of multi-gradient echo data sets are collected until M groups of multi-gradient echo data sets are obtained, and the M groups of multi-spin echo data sets and the M groups of multi-gradient echo data sets correspond to M different spin locking durations respectively; and performing fitting operation on the M groups of multi-spin echo data sets and the M groups of multi-gradient echo data sets to generate a quantitative atlas. According to the technical scheme, the problems that a traditional T1rho sequence is long in scanning time, low in signal-to-noise ratio and single in contrast ratio are effectively solved, and the technical effects of time multiplexing and multi-contrast imaging are achieved.

This application relates to a fully automated method and apparatus for quantitative analysis of myocardial acoustic contrast imaging. The method includes: acquiring myocardial acoustic contrast imaging images; segmenting the acquired myocardial acoustic contrast imaging images to obtain myocardial segmentation images; calculating the cardiac chamber area based on the myocardial segmentation images; automatically extracting the myocardial segmentation results at the end of cardiac systole using the periodic changes in cardiac chamber area; using the extracted end-systolic segmentation results as a mask to extract the corresponding position of each image as a target region for registration, thereby generating a one-to-one correspondence of registered image sequences; fitting a function model based on the pixel values ​​of each point in the registered image sequence; and generating a parametric image based on the registered image sequence and the fitted function model. Therefore, this application can perform fully automated quantitative analysis of myocardial acoustic contrast imaging.

This invention discloses a beam expander lens for laser scanning projection, relating to the field of laser projection display technology. It includes a first lens group, a second lens group, a third lens group, and a fourth lens group, arranged sequentially along the optical axis. These four lens groups together form the complete lens. The first, second, third, and fourth lens groups are arranged in a positive-negative-negative-negative optical power configuration. Through innovative optical architecture and optical power allocation, a large-angle beam expander function is achieved within a space of less than 35mm in total length, greatly saving internal space. By utilizing the chromatic aberration correction capability of the first lens group and the aberration correction capabilities of the second, third, and fourth lens groups, high-contrast imaging is achieved across the entire field of view and wavelength range, with concentrated dot matrix energy, meeting the requirements of high-resolution projection.

This invention discloses a low-pass filtered non-breath-hold saline angiography combined with cardiac mirror contrast imaging for lung perfusion imaging, belonging to the field of medical imaging technology. The method includes the following steps: S1: determining whether the subject's tidal impedance variation meets the imaging criteria; S2: injecting contrast agent into the subject to perform angiography; S3: obtaining an impedance decrease signal; S4: combining cardiac mirror contrast imaging with lung perfusion images. This invention solves the problem of low success rate of saline angiography in existing technologies, achieves separation of thoracic impedance caused by tidal breathing and thoracic impedance caused by saline angiography, reduces the influence of the cardiac region on lung perfusion images, further improves the accuracy of lung perfusion imaging, greatly reduces the interference of breath-holding on respiratory circulation, improves the simplicity of clinical application, and expands clinical application scenarios.

This application relates to the field of image information processing technology and provides a fusion contrast imaging method, a registration method and apparatus for intracavitary images and contrast images. The fusion contrast imaging method includes: acquiring contrast images and intracavitary images; fusing the contrast images and intracavitary images based on the correspondence between contrast markers and intracavitary markers to obtain a fusion contrast imaging result. This application links contrast images and intracavitary images through contrast markers and intracavitary markers, enabling intracavitary image information and contrast image information to correspond and be fused to obtain a fusion contrast imaging result, thereby overcoming the problem that traditional contrast images contain only a single type of information.

Systems and methods for simultaneous phase-contrast imaging and electron energy loss spectroscopy. The method and system for imaging a sample with charged particles include guiding charged particles toward the sample along a principal axis, and simultaneously detecting a first portion and a second portion of the charged particles transmitted through the sample using a first detector and a second detector, respectively. The second detector is positioned downstream of the first detector. Each of the transmitted charged particles exits the sample at an exit angle between the direction of the transmitted charged particle and the principal axis. The exit angle of the first portion of the transmitted charged particle overlaps with the exit angle of the second portion of the transmitted charged particle. In this way, complementary information, such as structural and compositional information, can be obtained simultaneously.

A system for analyzing biological components in a biological sample, wherein the system comprises a planar surface, and wherein the system is configured to perform a procedure comprising: (a) arranging a spatially connected biological sample adjacent to the planar surface, wherein: the spatially connected biological sample comprises a tissue sample, the tissue sample comprises a plurality of cells, the planar surface comprises glass, plastic, or a combination thereof, the planar surface further comprises a plurality of binding sites, the plurality of binding sites is arranged in a two-dimensional pattern on the planar surface, the planar surface comprises at least 10⁵ binding sites, each of the plurality of binding sites comprises a plurality of single-stranded oligonucleotides, and the plurality of single-stranded oligonucleotides is coupled to the planar surface.at least one subset of the plurality of single-stranded oligonucleotides comprises: (i) a binding sequence comprising a plurality of thymine bases configured to bind to poly-A sequences, (ii) a unique molecular identifier, (iii) a barcode associated with a position on the planar surface, and (iv) a sequencing primer, and each oligonucleotide of the subset of the plurality of single-stranded oligonucleotides comprises at least 50 nucleotides; (b) imaging at least a portion of the spatially linked biological sample, wherein the imaging comprises bright-field imaging, phase-contrast imaging, fluorescence imaging, or a combination thereof; (c) releasing nucleic acids from the spatially linked biological sample; and (d) capturing at least one subset of the nucleic acids on at least the subset of single-stranded oligonucleotides, thereby recovering the captured nucleic acids.the captured nucleic acids are immobilized on the flat surface.

This invention provides a method for charged particle beam (CPB) phase contrast imaging. [Solution] In a CPB system, the phase contrast image is obtained by directing a sample-modulated CPB to the phase plate so that it has a diffraction plane displaced from the phase plate. Based on the interference fringes of the image, the lateral displacement of the CPB relative to the phase plate can be estimated and adjusted.

This invention belongs to the field of acoustic detection technology for partial discharge in power equipment, and relates to an array-type acoustic imaging partial discharge detection method and system. The method includes: establishing the correspondence between channel identifier sequences and array geometric parameters; dividing the array into subgroups according to a fixed subgrid and generating a synchronous sampling time sequence to acquire multi-channel pulse density modulation signals; demodulating and extracting the signals, bandpass filtering and pulse framing; constructing a forward-backward spatial smoothing covariance matrix and using minimum variance distortionless response beamforming to calculate the spatial spectrum to generate an acoustic image; and registering and superimposing the acoustic image with a visible light image to output the positioning result. The technical solution of this application achieves high-contrast imaging and stable positioning output through temporal and geometric consistency constraints, which can improve the consistency of on-site interpretation and meet the requirement of repeatable positioning under weak partial discharge ultrasonic conditions.

The invention discloses a magnetic resonance non-enhanced lower limb arteriovenous combined imaging method, which belongs to the technical field of medical imaging, and comprises the following steps: S1, judging acquisition times and carrying out first acquisition, S2, setting delay time of data acquisition, S3, configuring a rapid interruption steady state and carrying out data acquisition, S4, repeating the steps S1 to S3 until all regions finish a data collection process of the first acquisition, the method comprises the following steps of S1, carrying out first acquisition, S2, carrying out second acquisition, S5, switching to second acquisition, judging the number of acquisition times, and carrying out second acquisition, S6, carrying out data acquisition by using the same process as S2 and S3, S7, repeating the steps S5 and S6 until all regions complete data collection of the second acquisition, and S8, carrying out image reconstruction to obtain an arteriovenous separation image. By fusing the fast interruption steady-state sequence and the golden angle radial sampling track, lower limb artery and vein synchronous high-contrast imaging is achieved under the condition that electrocardio gating is not needed.

The application discloses a high-performance visible light-long-wave infrared two-light-in-one optical system, and mainly solves the problems of large volume and weight of a traditional independent visible light system and an infrared waveband optical system. The optical system comprises a main reflector, a spectral light splitting element, a visible light continuous zoom optical module and a long-wave infrared optical module. A light beam from a target object is reflected by the main reflector and reaches the spectral light splitting element, and is then divided into two paths, one of which is reflected into the visible light continuous zoom optical module, and the other is transmitted into the long-wave infrared optical module. The main reflector, the spectral light splitting element and the visible light continuous zoom optical module jointly form a visible light continuous zoom optical system and receive visible light in the light beam; and the main reflector, the spectral light splitting element and the long-wave infrared optical module jointly form a long-wave infrared optical system and receive long-wave infrared light in the light beam. The optical system can meet the requirements of long-distance high-sensitivity detection and medium-short-distance high-resolution high-contrast imaging of the target.

The imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and / or spectral content of which are varied delivered through the same optical train including the set of apertures.

The utility model discloses a near-infrared lymph node detection system. The detection system comprises an infrared imaging system, the infrared imaging system comprises an excitation light source, a beam expanding element, a light path forwarding device, a light filtering device and a short-wave infrared sensor which are arranged along a light path, and an image processing and displaying device which is in communication connection with the short-wave infrared sensor; wherein the excitation light source is a continuous spectrum light source or a wavelength continuously adjustable light source. According to the utility model, based on a near infrared spectrum imaging technology known as a biological transparent window, image processing is carried out in combination with a model algorithm, and an innovative solution is provided for lymph node detection; according to the system, the low tissue scattering characteristic of a near-infrared window and the absorption peak difference characteristic of main biological components in a near-infrared spectrum are utilized, and high-contrast imaging of lymph nodes and surrounding adipose tissues is achieved without a tracer agent. The detection system provided by the utility model can provide real-time guidance and tracking for related operations.

The application relates to the technical field of medical devices, in particular to a skin ultrasound contrast-based axillary sentinel lymph node puncture guiding method. The core of the method is as follows: after injecting an ultrasound contrast agent with a specific particle size through the skin, a preset low-mechanical-index high-frame-rate double-amplitude contrast imaging mode is adopted to dynamically track lymph drainage and sentinel lymph node development, and the enhancement characteristics are recorded; then, under the guidance of multimodal imaging which is fused with real-time contrast, elastic imaging and color Doppler, the target lymph node is accurately punctured and biopsied, and a tissue sample is obtained for pathological analysis. The application realizes integrated operation from sensitive development of the sentinel lymph node, function evaluation to accurate puncture, and provides a non-radiation high-precision puncture guiding method for accurate evaluation of the axillary lymph node state of breast cancer patients before operation.

This invention relates to the field of high-contrast imaging with optical synthetic aperture, specifically to a method, medium, and device for precise detection of co-phase errors using non-coaxial beam-combining zero-elimination interferometry. This invention directly utilizes the non-coaxial zero-elimination interferometry signal for error inversion, eliminating the need for additional optical components. Furthermore, the algorithm does not require iteration, resulting in a high detection frequency, making it suitable for co-phase applications with high real-time requirements. The co-phase scheme of this invention can simultaneously demodulate tilt and piston errors with high precision using only the zero-elimination interferometry signal without adding additional optical components. This invention also demodulates relative tilt and piston errors using two-dimensional discrete Fourier transform, exhibiting strong anti-noise interference characteristics and making it suitable for co-phase applications with low signal-to-noise ratios.

The application discloses a kind of quantitative channel contrast imaging methods based on scanning electron microscope, electronic equipment and medium, comprising: the polycrystalline sample is placed into scanning electron microscope system, determines ROI, obtains crystal data;Adjust the state of polycrystalline sample, obtain the cross-correlation diagram of backscattered electron image and diffraction contrast value image, so that backscattered electron beam scanning area and ROI coincide;In ROI, optional one position, calculate ECP under the current electron beam energy;Determine target orientation on ECP, determine the optimal path of rotating polycrystalline sample to target orientation;Get backscattered electron image before and after rotation and cross-correlation, move polycrystalline sample so that backscattered electron beam scanning area before and after rotation coincide;Adjust scanning electron microscope system by the above steps, collect a series of backscattered electron images of ROI.The application can realize the characterization and analysis of block sample dislocation, nanotwin, stacking fault and other crystal defects by scanning electron microscope.

Disclosed are a method, device, and system for X-ray CT contrast imaging using magnetic nanoparticles. The method includes: rotating a target object containing magnetic nanoparticles as contrast agent for one circle relative to X-rays, recording multiple consecutive transmission projection images of the target object at all angles; for multiple transmission projection images at each angle, after conducting image post-processing operations, performing inverse projection transform on magnetic nanoparticle imaging projection images at all angles to obtain a tomographic imaging result. The image post-processing operation includes: time-frequency transform: converting the third dimension of the three-dimensional time domain matrix to frequency domain to obtain a three-dimensional frequency domain matrix; feature extraction: selecting a two-dimensional matrix with frequency of kf along the third dimension of the three-dimensional frequency domain image matrix; k is a positive integer; f is the frequency of the excitation magnetic field.

The invention provides a surgical imaging system with navigation and a precision correction method thereof, and the method comprises the steps: tracking the position of a positioning mark through a navigation module, and obtaining the calculation position of an imaging module in combination with a calibration relation; generating a virtual reference frame under the visual angle of the imaging module according to the calculation position of the imaging module and the position of the reference frame tracked by the navigation module; and correcting the calibration relation according to the deviation between the virtual reference frame under the visual angle of the imaging module and the actually seen reference frame. According to the method, the position of the imaging module is determined by tracking the positioning mark in combination with the pre-calibrated conversion relation, the position of the reference frame is tracked, then the virtual reference frame image under the visual angle of the imaging module is obtained through processing, and the real reference frame is obtained by comparing the virtual reference frame under the visual angle of the imaging module with the real reference frame. And the error of the calibration relation can be intuitively judged and corrected.

Systems and methods for medical contrast imaging are disclosed. Systems and methods of the present disclosure address the challenges of continental medical imaging by, for example, using contrast agents that facilitate use of low-risk wavelengths of imaging radiation, and / or by using imaging methods that facilitate imaging with resolution and / or image quality that are adequate for diagnosis, treatment, and / or any other suitable purpose(s). Examples of suitable wavelengths for the imaging radiation may include certain microwave and / or radio-frequency wavelengths that pose little to no health hazards.

Apparatuses, systems, and methods are provided for automatically selecting a first frame and a last frame of a sequence of frames from which a cumulative contrast image can be generated. In some examples, a statistical distribution of groups of pixels of the image frames can be analyzed to generate a parameter map. The parameter map can be analyzed to select a first image frame and a last image frame of the sequence. In some examples, an image frame corresponding to a parameter map having a value above a threshold can be selected as the first frame. In some examples, an image frame corresponding to a parameter map having a maximum value of all parameter maps can be selected as the last frame. In some examples, the parameter map can be used to segment features, such as tumors, from the image frames.

The invention relates to the technical field of biological materials, particularly provides folic acid-DOTA dual-functional nanoparticles for early-stage MRI (magnetic resonance imaging) detection of cancers, and also provides a preparation method of the folic acid-DOTA dual-functional nanoparticles and application of the folic acid-DOTA dual-functional nanoparticles in contrast imaging. The folic acid-DOTA dual-functional nano-particle provided by the invention comprises a hollow silicon dioxide nano-particle, the folic acid-PEG-maleimide and the DOTA-Gd are loaded on the surfaces of the hollow silicon dioxide nano particles. According to the invention, folic acid-PEG-maleimide is modified on the surfaces of hollow silicon dioxide nanoparticles, and specific enrichment of the MRI contrast agent in lung cancer tissues is realized by using a folic acid receptor mediated active targeting mechanism; meanwhile, by loading DOTA-Gd on the surface, the effective imaging window time is prolonged, the release risk of free gadolinium ions is reduced, and a safe and efficient nano radiography system is provided for precise diagnosis of lung cancer.

This invention relates to a computer-executed method for providing a synthetic contrast imaging scene, comprising: b.1) receiving preoperative image data of an examination region having a hollow organ, which images a contrast agent flow within the hollow organ; b.2) receiving intraoperative image data of an examination region of an examination subject, which images a medical object at least partially disposed within the hollow organ; b.3) generating a synthetic contrast imaging scene by applying a trained function to input data, said input data being based on the preoperative and intraoperative image data, wherein the synthetic contrast imaging scene images a virtual contrast agent flow within the hollow organ, taking into account the medical object disposed within the hollow organ, at least one parameter of the trained function being based on a comparison between a training scene and a comparison scene; and b.4) providing the synthetic contrast imaging scene. This invention relates to a computer-executed method for providing a trained function, a providing unit, a medical imaging device, a training unit, and a computer program product.

This invention discloses a differential interferometric phase-contrast imaging system, method, and time-difference incubator device, belonging to the fields of optical imaging and medical device technology. The system includes an illumination source module, a microscopic imaging module, a polarization interferometry module, and a quantitative phase image reconstruction module. By placing all polarization interferometry components, such as the polarizer and polarization beam splitter, on the image side of the microscopic imaging module, the imaging beam does not need to pass through the plastic culture dish before passing through the polarization elements, thus completely avoiding interference from plastic birefringence on the imaging and achieving high-quality observation of samples in cell biology or materials science fields within plastic culture dishes. Simultaneously, the system uses a polarization camera to simultaneously acquire multiple phase-shifted interferograms in a single exposure, combined with a quantitative phase reconstruction algorithm, achieving high-speed, high-precision quantitative phase imaging, overcoming the shortcomings of traditional mechanical phase-shifting methods, such as slow speed and susceptibility to motion artifacts. Furthermore, the imaging system of this invention can also be integrated into a time-difference incubator.

The invention discloses a super-resolution ultrasonic imaging method and an ultrasonic imaging system.The super-resolution ultrasonic imaging method comprises the steps that a target imaging mode is determined from at least two super-resolution contrast imaging modes, the imaging speeds of super-resolution images corresponding to the at least two super-resolution contrast imaging modes are different, and the imaging speeds of the super-resolution images corresponding to the at least two super-resolution contrast imaging modes are different; and / or the resolutions of the super-resolution images corresponding to the at least two super-resolution contrast imaging modes are different; obtaining target imaging data based on the target imaging mode; performing super-resolution imaging processing on the target imaging data based on the target imaging mode to obtain a super-resolution image corresponding to the target imaging mode; and displaying a super-resolution image corresponding to the target imaging mode. According to the super-resolution ultrasonic imaging method, multiple super-resolution contrast imaging modes can be provided for the user to select, super-resolution imaging processing is carried out according to the target imaging mode selected by the user, different clinical scenes can be met, and the applicability of super-resolution imaging is improved.

Systems and methods are provided for contrast scans. In one example, a computing device is configured to display a scan interface in a prescription view on a screen and to receive user input of a contrast observation slice for tracking arrival of a contrast bolus during a contrast scan. The screen is further configured to display a scanning button that can be reached directly from the scan interface, the scanning button selectable to launch a live scanning view of the scan interface that enables live 2D images of the contrast observation slice to seen within the scan interface. The live scanning view includes a contrast tracking display panel that displays an auto-triggering button that is selectable to enable auto-triggering of post-contrast image acquisition and that displays a contrast intensity plot determined from the live 2D images.

The invention discloses an ultrasonic contrast imaging method and an ultrasonic imaging system, and the method comprises the steps: controlling all array elements, half array elements and the other half array elements in a transmitting aperture of an ultrasonic probe to transmit a second ultrasonic wave, a third ultrasonic wave and a fourth ultrasonic wave to a target tissue, obtaining a second echo signal, a third echo signal and a fourth echo signal corresponding to the plurality of receiving channels; performing superposition cancellation on signals corresponding to the same receiving channel in the second echo signal, the third echo signal and the fourth echo signal to obtain contrast microbubble echo signals corresponding to the plurality of receiving channels; and performing beam forming on the contrast microbubble echo signals corresponding to the plurality of receiving channels to obtain contrast image data. According to the invention, the imaging frame rate of contrast imaging can be improved.

The embodiment of the invention discloses an ultrasonic contrast imaging method and system, electronic equipment and a storage medium, and the method comprises the steps: sequentially transmitting a plurality of plane waves in a plane wave group, and receiving an echo signal corresponding to each plane wave; a comparison pulse sequence method is adopted for the echo signal corresponding to each plane wave in the plane wave group, and a nonlinear signal corresponding to each plane wave is obtained; compounding based on the nonlinear signal corresponding to each plane wave to obtain a nonlinear enhanced signal corresponding to the plane wave group; and repeating the above steps until non-linear enhanced signals corresponding to the preset number of plane wave groups are obtained, and performing clutter filtering based on the non-linear enhanced signal corresponding to each plane wave group by using Doppler frequency shift characteristics to obtain an ultrasound contrast image. The imaging frame frequency is improved through plane wave emission, and the image quality is improved through multi-plane wave compounding; nonlinear tissue components are filtered out by using Doppler frequency shift characteristics, and the contrast tissue inhibition ratio is improved.

The invention discloses a three-dimensional super-resolution imaging method and ultrasonic imaging equipment, and the method comprises the steps: carrying out the ultrasonic scanning of a target object injected with contrast agent microbubbles through an area array ultrasonic probe in a super-resolution contrast imaging mode, so as to obtain ultrasonic body data, accumulating the position information of the contrast agent microbubbles in the ultrasonic body data of a region of interest, and obtaining the position information of the contrast agent microbubbles in the region of interest; according to the method, the three-dimensional super-resolution image of the region of interest is obtained and displayed by performing three-dimensional reconstruction on the region of interest, and the three-dimensional super-resolution image is presented, so that tiny structure details in the target object can be better observed.

This application provides a method and apparatus for rapid multi-contrast magnetic resonance imaging based on helical trajectory acquisition. The method includes: constructing a modular multi-contrast imaging pulse sequence composed of multiple preparation modules, each preparation module being used to generate different magnetic resonance signals; generating magnetic resonance signals according to the modular multi-contrast imaging pulse sequence, and acquiring the magnetic resonance signals using a helical trajectory to obtain acquired magnetic resonance signals; and performing imaging reconstruction based on the acquired magnetic resonance signals to obtain magnetic resonance images with different contrasts. This method improves the generation efficiency of magnetic resonance signals by generating magnetic resonance signals with different contrasts through a modular multi-contrast imaging pulse sequence. Since the helical acquisition trajectory has high encoding efficiency, using a helical trajectory acquisition can effectively improve the acquisition efficiency of magnetic resonance signals, thus increasing the imaging speed of multi-contrast magnetic resonance images.