54 results about "Brachytherapy" patented technology

The invention discloses a close-range radiotherapy plan optimization method and device based on a cumulative dose target. The method comprises the following steps: S1, importing current treatment data; s2, leading in a preorder treatment image and performing deformation registration to the current image; s3, mapping the preorder treatment dose to the current treatment image to serve as the background dose of the current treatment; s4, converting the dose data mapped to the current treatment image by the preorder treatment into a bioequivalent dose; s5, on the basis of the sketching data of the current treatment image and with reference to the clinical endangered organ dose limit value requirement, key area generation is carried out on each endangered organ; s6, based on the preorder treatment dosage, generating a corresponding organ-endangered high-risk dosage area and a target area insufficient area according to each organ-endangered dosage limit value and the target area prescription dosage; and S7, optimizing the treatment plan, and optimizing the treatment plan by taking the preorder treated dose and the sum of the planned dose to be optimized at the time to meet the clinical requirement as a target.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

This invention relates to the fields of brachytherapy and radiosensitization, specifically providing a... 125 I-nano implantable particles, their preparation methods, and applications. 125 The 1-nanometer implanted particles have a core-shell structure, consisting of a particle core and particles adsorbed on the outer surface of the particle core. 125 I and the particles encapsulated in the nucleus and 125 The outer shell of the I-type photosensitizer is a covalent organic framework. This invention... 125 The core of the I-nanometer implanted particle is used to enhance the energy deposition of gamma rays and X-rays, generating more hydroxyl radicals; the shell containing a type I photosensitizer is used to absorb the energy of Auger electrons and internal conversion electrons and excite the photosensitizer to generate singlet oxygen, effectively improving the response to... 125 The efficiency of I decay energy utilization. 125 I-nano implanted particles, combined with internal radiation therapy and radiodynamic therapy, destroy tumor cell DNA and cell membranes, enhance tumor killing and induce immunogenic cell death, thereby activating anti-tumor immunity and inducing remote effects.

This invention relates to a hydrogel isolation and protection device for cervical cancer brachytherapy and its preparation method. The preparation method includes the following steps: S1. Obtaining dried sodium polyacrylate particles and polyacrylamide powder separately, and mechanically mixing them uniformly in a dry state to obtain a highly absorbent dry-state mixed filler; S2. Preparing a polymer bag using a polymer material; S3. Inserting the outlet end of a water injection conduit into the polymer bag, and filling the polymer bag with the dry-state mixed filler; S4. Sealing the open end of the polymer bag to the outer wall of the water injection conduit to form a closed isolation device. The entire preparation process is carried out in a non-sterile environment, and microbial control of the device is limited to the outer surface of the polymer bag. This hydrogel isolation and protection device can be prepared using the above method.

1. Name of the product in this design: Dual-tube applicator. 2. Purpose of this design: A specialized device for delivering radiation sources to the target area in brachytherapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention provides a WRN inhibitor for use in the treatment of cancer, in particular microsatellite instability-high (MSI- H) or mismatch repair deficient (dMMR) cancer, wherein the treatment further comprises administration of: A. an ionising radiation-based therapy selected from: i) external beam radiation, ii) brachytherapy and Hi) a radiopharmaceutical, or B. carboplatin and paclitaxel; The WRN inhibitor is a compound of formula (1g) or compound C : Formula (C).

The present invention relates to polymer radiotherapy particles, compositions and methods of production thereof, wherein the radionuclides are alpha and / or beta-emitting radionuclides. The invention also relates to the use of said particles and compositions in the treatment of cancer and their use in localized region radiation therapy, brachytherapy and transarterial radioembolism.

The utility model discloses a kind of for cervical cancer's rear-mounted precision close-range treatment device, belong to the technical field of treatment equipment, including positioning plate, the positioning plate is equipped with through-hole, guiding column is installed in the through-hole, the inside both sides of the positioning plate are provided with adjusting hug device, the adjusting hug device passes through through-hole side wall, from both sides hug guiding column, the guiding column one end is provided with limit plate, the limit plate is located in the positioning plate side, the guiding column is equipped with central hole and several groups of side hole, central insertion pipe is installed in the central hole, side insertion pipe is installed in the side hole, the utility model discloses a kind of adapt to different patients use, improve the positioning effect of insertion needle, reduce the treatment device of influence to radiotherapy effect.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

A rotating shield brachytherapy (RSBT) apparatus includes a radiation source, at least one applicator, a catheter, a catheter drive assembly, a robotic positioning system, and a connection system. The applicator(s) is configured to be inserted or implanted into a patient. A distal end portion of the catheter has at least one radiation shield and is configured to receive a wire-mounted radiation source. The catheter drive assembly causes helical motion of the catheter and engages the proximal end portion of the catheter to selectively rotate the catheter about a longitudinal axis. The robotic positioning system aligns the catheter drive assembly, in both position and angular orientation at a modifiable rate, with the applicator(s), or to any programmed point in space. The connection system couples the catheter drive assembly to the applicator(s), and further decouple the catheter drive from the applicator(s).

The application discloses a kind of afterloading brachytherapy precision positioning device, it is characterized in that, including: catheter;First source applicator includes first main part, first slot part, first insertion part, first air bag and multiple first elastic film;Second source applicator includes second main part, second slot part, second insertion part, second air bag and multiple second elastic film;Wherein, afterloading brachytherapy precision positioning device is configured as: in working condition, first opposite surface and second opposite surface hold fixed catheter, first insertion part inserts second slot part and extrudes second air bag, second elastic film is deformed and protrudes on second circumferential surface;Second insertion part inserts first slot part and extrudes first air bag, first elastic film is deformed and protrudes on first circumferential surface.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and / or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and / or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

1. The name of the design product: afterloading therapy machine. 2. The use of the design product: for the brachytherapy of human malignant tumor. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

A device with a central cylinder including multiple passageways and a plurality of channels spaced circumferentially around the central passageway. The device further includes a ring with a plurality of outlets and a plurality of frames coupled to the ring. Each of the plurality of frames includes a frame channel, a frame opening, and a distal end coupled to one of the plurality of outlets. A plurality of supports extend between the cylinder and the plurality of frames, and each of the plurality of supports is coupled to the cylinder with an adjustable lock. Each of the plurality of frames is adjustable with respect to the cylinder in response to movement of the corresponding adjustable lock with respect to the cylinder.

The application provides a vagina after-loading guide implant needle treatment device, a production equipment and a production process, and belongs to the technical field of brachytherapy equipment for cervical cancer. The vagina after-loading guide implant needle treatment device comprises a guide main body and a positioning damping sleeve. The guide main body comprises a guide head end, an intermediate cylinder, a tail end cylinder and an extension handle. The positioning damping sleeve is arranged at the front end of the guide head end. A plurality of groups of straight implant needle channels and a plurality of groups of inclined implant needle channels are arranged through the guide main body. The production equipment of the vagina after-loading guide implant needle treatment device comprises a first injection molding device for producing the guide head end and the tail end cylinder and a second injection molding device for producing the intermediate cylinder and the extension handle. Each component is separately injection molded, and the straight implant needle channels and the inclined implant needle channels are demolded. The vagina after-loading guide implant needle treatment device, the production equipment and the production process improve the production efficiency and reduce the production cost.

The invention relates to a metal artifact correction method for a cervical brachytherapy CT image, and the method comprises the following steps: carrying out the metal artifact synthesis processing of a cervical cancer EBRT CT image, and obtaining a synthesized image; constructing a metal artifact correction model; training a metal artifact correction model by adopting the composite image and the original EBRT CT image; performing metal artifact correction processing on the cervical BT CT image by adopting the trained metal artifact correction model to obtain a corrected CT image; according to the method, the artifact image containing the synthetic cavity artifact is simulated and generated from the EBRT CT image, the large-scale synthetic pairing data set is constructed and used for model training, the trained metal artifact correction model is adopted to carry out metal artifact correction processing on the cervical BT CT image, and the metal artifact of the cervical BT CT image can be effectively removed.

The utility model discloses an adjustable angle's cervical cancer short distance radiotherapy implantation template belongs to medical technical field, including implantation board, is seted up with mounting hole on the implantation board, is installed with implantation column in the mounting hole, implantation column one end is provided with mounting panel, and the mounting panel is away from the one side abutment of implantation board of implantation column, is seted up with a plurality of groups first implantation hole channel on the mounting panel, the first implantation hole channel inside is provided with angle regulator, is used for adjusting needle angle, the utility model discloses an adjustable implantation needle angle, guarantees radiotherapy position accurate, and the radiotherapy implantation template of strong flexibility.

The present invention discloses a method for predicting the therapeutic dose of brachytherapy for gliomas, which relates to the technical field of therapeutic dose prediction. The method comprises the following steps: acquiring patient data and extracting key patient data, constructing a network CDC Transformer model, training the network CDC Transformer model, and outputting a therapeutic dose prediction result through the network CDC Transformer model. The present invention realizes automatic prediction of the therapeutic dose of brachytherapy for gliomas by constructing a network CDC Transformer model based on the Transformer model. Channel spatial attention is added before the downsampling process of the original Transformer model to automatically allocate channel weights and enhance the prediction result. The method does not rely on the personal experience of doctors and physicists, and can more accurately predict the dose distribution.

The present invention relates to the field of medical device technology, specifically a multifunctional automatic needle insertion device that can automatically insert an implant needle into human tissue, automatically remove the needle core, and automatically replace the implant needle during temporary close-range radiotherapy; the device can improve the problems of instability and inaccuracy caused by doctors mainly relying on hand feeling and experience judgment when inserting the needle; the device comprises a multi-degree-of-freedom robot (1), a short-distance moving unit (2), a mobile clamping unit, a guide mold unit, and a clamping unit; the multi-degree-of-freedom robot (1) is used to move the end device to a suitable position; the short-distance moving end unit (2) is used to complete the linear motion required for needle insertion and needle core removal; the mobile clamping unit is used to clamp the implant needle (7) so that the linear motion of the short-distance moving unit (2) can be transmitted to the implant needle (7); the guide mold unit is used to provide guidance; and the clamping unit is used to control the closing and opening of the guide mold and clamp the implant needle.

Various embodiments are described herein for a device and method for an integrated electromagnetic radiation treatment system comprising a sheath device and an electromagnetic radiation treatment delivery device for precise delivery of treatment to lesions on mucosal surfaces within body lumens. The system ensures accurate positioning of treatment applicators for brachytherapy and photodynamic therapy with simple visual confirmation, facilitating simple, low-tech, targeted treatment. The invention is particularly beneficial in settings where advanced imaging technologies are not available, offering a cost-effective and time-efficient solution for treatment planning and delivery.

According to the automatic checking method for the afterloading radiotherapy plan, nested jump connection and deep supervision are added in the improved U-Net + + model, and an attention mechanism (such as an SE module) is introduced, so that the feature weight of a source applicator region is enhanced, and the segmentation of a small target is more accurate. In addition, the decoder adopts residual connection, so that the problem of gradient disappearance of the deep network is relieved, and the segmentation accuracy of the small target is further improved. Besides, the classification model is based on the segmentation result of the U-Net + + model, and an MBConv module is added in the classification model, so that the classification precision of the source applicator, especially a small-target source applicator, is greatly improved, and the automation degree of after-loading radiotherapy plan verification is improved at the same time.

The invention relates to the technical field of medical devices, in particular to an intelligent temperature control brachytherapy source applicator external member which comprises a source applicator and an external member body. The outer side of the advancing end of the source applicator is provided with an outer sleeve piece used for conducting deep regional thermal therapy on a patient, one side of the outer sleeve piece is provided with a heat insulation sleeve for achieving the heat insulation purpose, and the center of the heat insulation sleeve is provided with a mounting groove; wherein the interior of the mounting groove is matched with thermal therapy pieces with two thermal therapy modes, and the thermal therapy pieces are divided into a first thermal therapy piece and a second thermal therapy piece; temperature monitoring modules for temperature monitoring are mounted in the heat insulation sleeve at the upper and lower parts of the mounting groove; one end of the source applicator is provided with the external sleeve member, one side of the external sleeve member is provided with the thermal therapy member used for heating for treatment, when radiotherapy is carried out, the thermal therapy member with controllable temperature is started to carry out deep regional thermal therapy, and the radiotherapy and the thermal therapy are matched, so that the tumor treatment effect of a patient is better.

Presented herein are systems and methods for determining quality of brachytherapy treatment plans from catheter placement in organs in subjects. A computing system can identify a biomedical image of a section associated with an organ of a subject to be administered with brachytherapy in accordance with a treatment plan. The computing system can detect, from the biomedical image, (i) a plurality of positions corresponding to a plurality of catheters placed within the organ and (ii) a contour defining a structure of interest (SOI) in the biomedical image corresponding to a feature within the organ. The computing system can provide the plurality of positions and the contour as input to a machine learning (ML) model. The computing system can generate, based on providing the input to the ML model, a metric indicating a quality of the treatment plan for the plurality of catheters placed relative to the feature within the organ.

The invention relates to the technical field of radioactive degradable nano materials with tracing and treatment effects, in particular to a radioactive degradable nano material for tracing and treating tumors and a preparation method of the radioactive degradable nano material. The invention provides a radioactive degradable nano-material for tracing and treating tumors, the radioactive degradable nano-material has a shell-core structure, the radioactive degradable nano-material comprises an amphiphilic polymer and radioactive element-labeled hypericin, and the amphiphilic polymer wraps the radioactive element-labeled hypericin. According to the degradable nano material, the water solubility of the hypericin can be improved, the photosensitive stability of the hypericin is enhanced, and triple functions of targeted necrosis, brachytherapy and tracing imaging are realized.

The invention discloses a cervical cancer brachytherapy dose planning reverse optimization method based on a trust region. The cervical cancer brachytherapy dose planning reverse optimization method comprises the steps of determining a target region and a risk organ; defining the position and direction of the catheter, and determining the residence position of the radioactive source on the catheter and a residence time matrix corresponding to the residence position; establishing a dose planning control model in combination with the risk organ and the residence time matrix; and solving the dose planning control model through an adaptive trust region algorithm based on GPU acceleration to obtain a dose planning optimal solution. According to the method, the cervical cancer brachytherapy dose is planned by establishing the dose planning control model, and specifically, by optimizing the dwell time of a radioactive source point and setting a weighted risk organ dosimetry index and a weighted normal tissue dosimetry index, the conformity of a tumor organ is improved, the dosimetry index of the risk organ is met, and the therapeutic effect of the cervical cancer brachytherapy is improved. The radiation dose required by a clinical prescription on a tumor organ is uniformly distributed in the tumor organ as much as possible, and a foundation is laid for realizing a high-precision treatment effect.