27 results about "Brachytherapy" patented technology

This invention relates to the fields of brachytherapy and radiosensitization, specifically providing a... 125 I-nano implantable particles, their preparation methods, and applications. 125 The 1-nanometer implanted particles have a core-shell structure, consisting of a particle core and particles adsorbed on the outer surface of the particle core. 125 I and the particles encapsulated in the nucleus and 125 The outer shell of the I-type photosensitizer is a covalent organic framework. This invention... 125 The core of the I-nanometer implanted particle is used to enhance the energy deposition of gamma rays and X-rays, generating more hydroxyl radicals; the shell containing a type I photosensitizer is used to absorb the energy of Auger electrons and internal conversion electrons and excite the photosensitizer to generate singlet oxygen, effectively improving the response to... 125 The efficiency of I decay energy utilization. 125 I-nano implanted particles, combined with internal radiation therapy and radiodynamic therapy, destroy tumor cell DNA and cell membranes, enhance tumor killing and induce immunogenic cell death, thereby activating anti-tumor immunity and inducing remote effects.

This invention relates to a hydrogel isolation and protection device for cervical cancer brachytherapy and its preparation method. The preparation method includes the following steps: S1. Obtaining dried sodium polyacrylate particles and polyacrylamide powder separately, and mechanically mixing them uniformly in a dry state to obtain a highly absorbent dry-state mixed filler; S2. Preparing a polymer bag using a polymer material; S3. Inserting the outlet end of a water injection conduit into the polymer bag, and filling the polymer bag with the dry-state mixed filler; S4. Sealing the open end of the polymer bag to the outer wall of the water injection conduit to form a closed isolation device. The entire preparation process is carried out in a non-sterile environment, and microbial control of the device is limited to the outer surface of the polymer bag. This hydrogel isolation and protection device can be prepared using the above method.

1. Name of the product in this design: Dual-tube applicator. 2. Purpose of this design: A specialized device for delivering radiation sources to the target area in brachytherapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention relates to polymer radiotherapy particles, compositions and methods of production thereof, wherein the radionuclides are alpha and / or beta-emitting radionuclides. The invention also relates to the use of said particles and compositions in the treatment of cancer and their use in localized region radiation therapy, brachytherapy and transarterial radioembolism.

The utility model discloses a kind of for cervical cancer's rear-mounted precision close-range treatment device, belong to the technical field of treatment equipment, including positioning plate, the positioning plate is equipped with through-hole, guiding column is installed in the through-hole, the inside both sides of the positioning plate are provided with adjusting hug device, the adjusting hug device passes through through-hole side wall, from both sides hug guiding column, the guiding column one end is provided with limit plate, the limit plate is located in the positioning plate side, the guiding column is equipped with central hole and several groups of side hole, central insertion pipe is installed in the central hole, side insertion pipe is installed in the side hole, the utility model discloses a kind of adapt to different patients use, improve the positioning effect of insertion needle, reduce the treatment device of influence to radiotherapy effect.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and / or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and / or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

1. The name of the design product: afterloading therapy machine. 2. The use of the design product: for the brachytherapy of human malignant tumor. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

A device with a central cylinder including multiple passageways and a plurality of channels spaced circumferentially around the central passageway. The device further includes a ring with a plurality of outlets and a plurality of frames coupled to the ring. Each of the plurality of frames includes a frame channel, a frame opening, and a distal end coupled to one of the plurality of outlets. A plurality of supports extend between the cylinder and the plurality of frames, and each of the plurality of supports is coupled to the cylinder with an adjustable lock. Each of the plurality of frames is adjustable with respect to the cylinder in response to movement of the corresponding adjustable lock with respect to the cylinder.

The invention relates to a metal artifact correction method for a cervical brachytherapy CT image, and the method comprises the following steps: carrying out the metal artifact synthesis processing of a cervical cancer EBRT CT image, and obtaining a synthesized image; constructing a metal artifact correction model; training a metal artifact correction model by adopting the composite image and the original EBRT CT image; performing metal artifact correction processing on the cervical BT CT image by adopting the trained metal artifact correction model to obtain a corrected CT image; according to the method, the artifact image containing the synthetic cavity artifact is simulated and generated from the EBRT CT image, the large-scale synthetic pairing data set is constructed and used for model training, the trained metal artifact correction model is adopted to carry out metal artifact correction processing on the cervical BT CT image, and the metal artifact of the cervical BT CT image can be effectively removed.

The utility model discloses an adjustable angle's cervical cancer short distance radiotherapy implantation template belongs to medical technical field, including implantation board, is seted up with mounting hole on the implantation board, is installed with implantation column in the mounting hole, implantation column one end is provided with mounting panel, and the mounting panel is away from the one side abutment of implantation board of implantation column, is seted up with a plurality of groups first implantation hole channel on the mounting panel, the first implantation hole channel inside is provided with angle regulator, is used for adjusting needle angle, the utility model discloses an adjustable implantation needle angle, guarantees radiotherapy position accurate, and the radiotherapy implantation template of strong flexibility.

According to the automatic checking method for the afterloading radiotherapy plan, nested jump connection and deep supervision are added in the improved U-Net + + model, and an attention mechanism (such as an SE module) is introduced, so that the feature weight of a source applicator region is enhanced, and the segmentation of a small target is more accurate. In addition, the decoder adopts residual connection, so that the problem of gradient disappearance of the deep network is relieved, and the segmentation accuracy of the small target is further improved. Besides, the classification model is based on the segmentation result of the U-Net + + model, and an MBConv module is added in the classification model, so that the classification precision of the source applicator, especially a small-target source applicator, is greatly improved, and the automation degree of after-loading radiotherapy plan verification is improved at the same time.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

The invention discloses lanthanum protein engineered bacterial embolism microspheres as well as a preparation method and application thereof, and belongs to the technical field of biological medicine agents. The lanthanum protein engineered bacterial embolism microsphere is prepared by the following steps: preparing a microemulsion from a functional water phase containing a microsphere matrix, functional bacteria and a photo-crosslinking agent and an oil phase containing an emulsifier and an oil phase component, and carrying out a cross-linking reaction. According to the lanthanum protein engineered bacterial embolism microspheres prepared by the method, lanthanum protein is specifically combined with radionuclide, so that rapid and efficient radioactive labeling with LanM protein on the surfaces of bacteria is realized, and labeling is realized at any time when the lanthanum protein engineered bacterial embolism microspheres are used. The radionuclide-containing microspheres can be accurately delivered to a tumor blood supply artery through an intervention means, and after the radionuclide-containing microspheres are retained in a tumor area, multiple treatment functions are achieved: PEGDA hydrogel provides physical embolism, slowly releases bacteria PAMPs and activates immunity, meanwhile, close-range radiotherapy is achieved through lanthanum protein anchoring 90Y, and finally the'embolism-biology-radiotherapy 'triple synergistic anti-tumor effect is achieved.

The invention relates to a classification pre-judgment method and system for a brachytherapy source applicator uterine cavity tube. The prediction method comprises the following steps: A, preprocessing a medical image; b, constructing a deep learning classification prediction model; c, model training; d, outputting a result: inputting the independent test verification set into a pre-judgment system in sequence to obtain the probability of occurrence of each inclination angle; e, classification prediction result evaluation: based on a sklearn database, respectively calculating an ROC curve lower area value AUCi of each inclination angle classification for an independent test verification set and a model training set; aUCi of all independent test verification sets and model training sets is subjected to arithmetic averaging, and the result is used for evaluating the accuracy of system prediction through a final AUC result. Through artificial intelligence and medical imaging technologies, before the source applicator is implanted, the optimal bending angle of the uterine cavity tube is predicted and judged, the accuracy of the prediction system is quantitatively evaluated, a decision basis is provided for implementation of clinical after-loading treatment, the pain of a patient is relieved, and the treatment efficiency is improved.

A medical device with a tracked injection needle or elongated probe is disclosed. The medical device includes a tracking element operably connected to the tip of the elongated probe. The tracking element is operably connected, or connectable, to a tracking apparatus that is configured to actively track positioning of the tip of the elongated probe in substantially real¬ time when the elongated probe is inserted into a tissue. The medical device can be manually driven to the target using information from the tip tracking or coupled with a motor that assists in directing the navigation to the target.

Disclosed herein are methods, pharmaceutical compositions, and kits for image-guided brachytherapy. An example method includes navigating a hollow tube to a tumor in a subject using an imaging modality and administering a pharmaceutical composition through the hollow tube to the tumor. An example pharmaceutical composition includes a pharmaceutically acceptable excipient and a collection of self-assembling conjugates, each self-assembling conjugate including a radionuclide coupled to an elastin-like polypeptide, the collection of self-assembling conjugates being included in the pharmaceutical composition at a concentration of no more than 300 µM.

This invention addresses the lack of auxiliary devices for targeted radiation to the tumor site in existing intestinal implantation therapy. It provides a novel fixation mold for a rectal brazing radiotherapy applicator, comprising a connecting base and an implantation column. The implantation column is fixedly mounted on one side of the connecting base, which has connecting holes for connecting to external structures. The implantation column contains implantation holes parallel to its axis, distributed at equal angles around the axis of the column. These holes penetrate both the connecting base and the implantation column. By providing several equally angled implantation holes, it is easier to control the uneven distribution of implantation needles to correspond to eccentric rectal cancer tumors, thus achieving a more rational arrangement of the implantation needles.

A brachytherapy seed applicator, comprising a hollow needle; a non-metallic elongated tube configured for insertion into tissue, within the hollow needle; a hub at a proximal end of the non-metallic elongated tube; one or more brachytherapy seeds carrying radioactive particles, within the non-metallic elongated tube; and a stylet configured to be inserted into the non-metallic elongated tube and to push the one or more brachytherapy seeds to a distal end of the non-metallic elongated tube, when the non-metallic elongated tube is in the tissue.

A close-range positioning multifunctional translation bed for radiotherapy relates to the technical field of bedding assistive devices for radiotherapy equipment, and is characterized in that an upper frame is fixedly arranged at the top of a bed frame, a bed board is erected on the upper frame, a lateral movement adjusting mechanism is arranged on the upper frame, and a limiting supporting mechanism is arranged on the bed frame; by arranging the structure capable of being laterally unfolded, the bed board can be laterally moved and supported after the structure is unfolded, meanwhile, the device is further provided with the limiting supporting structure for reinforcing and supporting the laterally unfolded structure, so that the bed board of the device can be laterally moved and adjusted, and a user can lie on the bed board; and the position of the user is adjusted by moving the bed board.

The invention discloses a cervical cancer brachytherapy dose prediction method based on deep learning. The method comprises the following steps: preprocessing cervical cancer image data, constructing a data set, establishing and training a dose prediction network model, and inputting a test set to obtain a dose prediction distribution result; according to the method, a network model adopts a double-encoder architecture and is used for extracting deep features of an input image in a layered manner and compressing data dimensions, a decoder performs up-sampling step by step so as to recover spatial details and reconstruct dose distribution, and meanwhile, jump connection is introduced between the encoder and the decoder, so that multi-scale feature fusion is realized; therefore, the feature expression ability of the model to the organ boundary region is enhanced, and the accuracy of dose prediction in the edge region is effectively improved. According to the invention, the problems of low dose prediction precision and the like caused by complex structure, large target shape and size change and fuzzy tumor boundary in a cervical cancer dose prediction task are solved, and the accuracy and clinical practicability of a prediction result are remarkably improved.

The application provides a cervical cancer brachytherapy segmentation mode prediction method based on a graph neural network. The method comprises the following steps: obtaining a cervical cancer data set; the cervical cancer data set is an electronic medical record containing the clinical treatment information of each cervical cancer patient; preprocessing the cervical cancer data set; inputting the preprocessed cervical cancer data set into a GPT2 model for data generation to generate synthetic data; evaluating the quality of the synthetic data and selecting the synthetic data with the highest similarity to the preprocessed cervical cancer data set; selecting the synthetic data with the highest similarity to the preprocessed cervical cancer data set as the basis data, using a dynamic feature aggregation graph neural network to capture the treatment feature relationship of the cervical cancer patient, and predicting the corresponding treatment scheme. The application uses synthetic data generated based on the GPT2 model to solve the problem of insufficient medical data, and uses the method of dynamically capturing the relationship between patient features by the graph neural network to more accurately and effectively predict the treatment scheme of the patient.