74 results about "Brachytherapy" patented technology

The invention discloses a cervical cancer close-range radiotherapy high-risk target area sketching method fused with a multi-modal image. The method comprises the following steps of collecting an MRI image scanned before radiotherapy and a CT image during radiotherapy of a cervical cancer close-range radiotherapy patient and annotation data of the MRI image and the CT image; the method comprises the following steps: preprocessing an MRI image scanned before radiotherapy and a CT image during radiotherapy, and converting annotation data into a three-dimensional tag image; on the basis of the preprocessed MRI image, the preprocessed CT image and the three-dimensional label image of the preprocessed MRI image, the preprocessed CT image and the three-dimensional label image of the preprocessed MRI image, registration of the MRI image and the CT image is conducted through a pre-constructed registration neural network model, feature extraction and fusion are conducted on the registered MRI image and the registered CT image through a pre-constructed high-risk target area automatic segmentation neural network model of a multi-scale cross-modal attention mechanism, and the high-risk target area automatic segmentation neural network model of the multi-scale cross-modal attention mechanism is obtained. Automatic delineation of a cervical cancer close-range radiotherapy high-risk target area is realized; according to the method, automatic segmentation of HR-CTV in close-range radiotherapy of cervical cancer is realized, high efficiency, accuracy and generalizability are realized, and intelligent support can be provided for clinical work.

The invention provides a deep learning-based automatic sketching method and system for high-risk clinical target regions and endangered organs in cervical cancer brachytherapy, and is applied to the technical field of data processing. According to the application, CT image information and MR image information of a cervical cancer patient are processed based on a positioning network, and 3D position information and form information of a source applicator and image feature sequence information are generated; performing classification processing on the CT image information of the cervical cancer patient based on a positioning network, and generating a priori knowledge label; processing the priori knowledge label based on the segmentation network, and generating a source applicator positioning target factor; the source applicator positioning target factor, the 3D position information and form information of the source applicator and the image feature sequence information are processed based on the segmentation network, and high-risk clinical target region and organ segmentation parameter information is generated; and processing the high-risk clinical target region and organ segmentation parameter information to generate an automatic sketching result of the high-risk clinical target region and the organ at risk for cervical cancer close-range treatment.

A shield assembly for an intensity modulated brachytherapy (IMBT) system, has: a tubular applicator engageable to a rotating mechanism of the IMBT system, the tubular applicator having a peripheral wall enclosing an internal cavity extending longitudinally along a central axis; a radiation shield extending axially along the central axis and received within the internal cavity, the radiation shield made of an MRI-compatible and radiation attenuating material; and a radionuclide-receiving passage within the internal cavity of the tubular applicator, the radionuclide-receiving passage extending axially and being radially offset from the central axis.

The invention discloses a close-range radiotherapy plan optimization method and device based on a cumulative dose target. The method comprises the following steps: S1, importing current treatment data; s2, leading in a preorder treatment image and performing deformation registration to the current image; s3, mapping the preorder treatment dose to the current treatment image to serve as the background dose of the current treatment; s4, converting the dose data mapped to the current treatment image by the preorder treatment into a bioequivalent dose; s5, on the basis of the sketching data of the current treatment image and with reference to the clinical endangered organ dose limit value requirement, key area generation is carried out on each endangered organ; s6, based on the preorder treatment dosage, generating a corresponding organ-endangered high-risk dosage area and a target area insufficient area according to each organ-endangered dosage limit value and the target area prescription dosage; and S7, optimizing the treatment plan, and optimizing the treatment plan by taking the preorder treated dose and the sum of the planned dose to be optimized at the time to meet the clinical requirement as a target.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

The invention provides an implantation guide device for cervical cancer brachytherapy minimally invasive surgery, which comprises a main body frame and a connecting assembly arranged at the top end of the main body frame, an adjusting assembly is arranged at one end of the connecting assembly, and a guide channel is inserted into the adjusting assembly; wherein the main body frame adopts the design conforming to human engineering and is convenient to operate, the adjusting assembly can flexibly adjust the guide angle and depth according to operation requirements, the guide channel has high precision and stability and ensures accurate insertion of an implantation instrument, and the adjusting assembly and the connecting assembly are of an angle-adjustable structure and are used for ensuring adjustment of the guide channel; relates to the technical field of medical instruments, effectively improves the accuracy and flexibility of surgical implanting operation through unique structural design, provides powerful support for close-range treatment of cervical cancer, and has the advantages of reasonable structure, convenience in operation, high precision and the like.

This invention relates to the fields of brachytherapy and radiosensitization, specifically providing a... 125 I-nano implantable particles, their preparation methods, and applications. 125 The 1-nanometer implanted particles have a core-shell structure, consisting of a particle core and particles adsorbed on the outer surface of the particle core. 125 I and the particles encapsulated in the nucleus and 125 The outer shell of the I-type photosensitizer is a covalent organic framework. This invention... 125 The core of the I-nanometer implanted particle is used to enhance the energy deposition of gamma rays and X-rays, generating more hydroxyl radicals; the shell containing a type I photosensitizer is used to absorb the energy of Auger electrons and internal conversion electrons and excite the photosensitizer to generate singlet oxygen, effectively improving the response to... 125 The efficiency of I decay energy utilization. 125 I-nano implanted particles, combined with internal radiation therapy and radiodynamic therapy, destroy tumor cell DNA and cell membranes, enhance tumor killing and induce immunogenic cell death, thereby activating anti-tumor immunity and inducing remote effects.

This invention relates to a hydrogel isolation and protection device for cervical cancer brachytherapy and its preparation method. The preparation method includes the following steps: S1. Obtaining dried sodium polyacrylate particles and polyacrylamide powder separately, and mechanically mixing them uniformly in a dry state to obtain a highly absorbent dry-state mixed filler; S2. Preparing a polymer bag using a polymer material; S3. Inserting the outlet end of a water injection conduit into the polymer bag, and filling the polymer bag with the dry-state mixed filler; S4. Sealing the open end of the polymer bag to the outer wall of the water injection conduit to form a closed isolation device. The entire preparation process is carried out in a non-sterile environment, and microbial control of the device is limited to the outer surface of the polymer bag. This hydrogel isolation and protection device can be prepared using the above method.

1. Name of the product in this design: Dual-tube applicator. 2. Purpose of this design: A specialized device for delivering radiation sources to the target area in brachytherapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention provides a WRN inhibitor for use in the treatment of cancer, in particular microsatellite instability-high (MSI- H) or mismatch repair deficient (dMMR) cancer, wherein the treatment further comprises administration of: A. an ionising radiation-based therapy selected from: i) external beam radiation, ii) brachytherapy and Hi) a radiopharmaceutical, or B. carboplatin and paclitaxel; The WRN inhibitor is a compound of formula (1g) or compound C : Formula (C).

The present invention relates to polymer radiotherapy particles, compositions and methods of production thereof, wherein the radionuclides are alpha and / or beta-emitting radionuclides. The invention also relates to the use of said particles and compositions in the treatment of cancer and their use in localized region radiation therapy, brachytherapy and transarterial radioembolism.

The utility model discloses a kind of for cervical cancer's rear-mounted precision close-range treatment device, belong to the technical field of treatment equipment, including positioning plate, the positioning plate is equipped with through-hole, guiding column is installed in the through-hole, the inside both sides of the positioning plate are provided with adjusting hug device, the adjusting hug device passes through through-hole side wall, from both sides hug guiding column, the guiding column one end is provided with limit plate, the limit plate is located in the positioning plate side, the guiding column is equipped with central hole and several groups of side hole, central insertion pipe is installed in the central hole, side insertion pipe is installed in the side hole, the utility model discloses a kind of adapt to different patients use, improve the positioning effect of insertion needle, reduce the treatment device of influence to radiotherapy effect.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

A rotating shield brachytherapy (RSBT) apparatus includes a radiation source, at least one applicator, a catheter, a catheter drive assembly, a robotic positioning system, and a connection system. The applicator(s) is configured to be inserted or implanted into a patient. A distal end portion of the catheter has at least one radiation shield and is configured to receive a wire-mounted radiation source. The catheter drive assembly causes helical motion of the catheter and engages the proximal end portion of the catheter to selectively rotate the catheter about a longitudinal axis. The robotic positioning system aligns the catheter drive assembly, in both position and angular orientation at a modifiable rate, with the applicator(s), or to any programmed point in space. The connection system couples the catheter drive assembly to the applicator(s), and further decouple the catheter drive from the applicator(s).

The application discloses a kind of afterloading brachytherapy precision positioning device, it is characterized in that, including: catheter;First source applicator includes first main part, first slot part, first insertion part, first air bag and multiple first elastic film;Second source applicator includes second main part, second slot part, second insertion part, second air bag and multiple second elastic film;Wherein, afterloading brachytherapy precision positioning device is configured as: in working condition, first opposite surface and second opposite surface hold fixed catheter, first insertion part inserts second slot part and extrudes second air bag, second elastic film is deformed and protrudes on second circumferential surface;Second insertion part inserts first slot part and extrudes first air bag, first elastic film is deformed and protrudes on first circumferential surface.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and / or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and / or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

The invention provides a close-range radiotherapy template printing data determination method. According to the method, medical image data of a to-be-detected area of a target object is acquired, an original radiotherapy template three-dimensional model is generated according to the medical image data, and then a receptor area and a diffusion area on a source application curved surface are determined according to the receptor curved surface of target tissue in the to-be-detected area; a needle insertion channel set is generated in the original radiotherapy template three-dimensional model, and target radiotherapy template printing data is generated according to the original radiotherapy template three-dimensional model and the needle insertion channel set; therefore, the radiotherapy template formed after the determined radiotherapy template printing data is subjected to three-dimensional printing can utilize the receptor area to realize comprehensive coverage of the current tumor tissue, and can also utilize the diffusion area to realize prediction matching of tumor tissue edge development. The complex process of repeatedly sampling medical images and manufacturing radiotherapy templates is effectively avoided.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

Disclosed herein is a fixation element for an applicator for use in brachytherapy. The fixation element comprises a first component comprising a camming portion and a lever portion; and a second component comprising a securement portion forming an opening for receiving the applicator. The securement portion comprises an abutment portion, and a first component receiving portion. Wherein, in a first position, the first component is received in the first component receiving portion, and wherein the fixation element is configured to transition from the first position to a second position as the lever portion is actuated. The actuation of the lever portion causing the camming portion to exert a force against the abutment portion, and as the force is exerted against the abutment portion, the opening formed by the securement portion constricts.

1. The name of the design product: afterloading therapy machine. 2. The use of the design product: for the brachytherapy of human malignant tumor. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

The invention provides gynecological tumor close-range radiotherapy simulation training teaching equipment, and relates to the technical field of simulation training, the gynecological tumor close-range radiotherapy simulation training teaching equipment comprises an operation table and a source applicator body, the top of the operation table is provided with a simulation mechanism, the simulation mechanism comprises a human body model, and the inner surface of the human body model is fixedly connected with a lower model and an end part model; the lower model is fixedly connected with the end part model, the outer surface of the lower model is slidably connected with two upper models, the design of a valve of a water inlet of each elastic bag enables tumors at different positions to be simulated, and a trainer can do repeated practice aiming at different tumor positions and can be quickly familiar with an operation path of a source applicator in a complex human body structure; practical operation accuracy is greatly improved, the process of tumor heating retraction is simulated, actual changes of tumors in radiotherapy are realistically restored, a trainer is helped to visually understand the radiotherapy principle and master the core skills of adjusting source applicator parameters according to the changes of the tumors, and the adaptation period from theoretical learning to clinical practice is effectively shortened.

A device with a central cylinder including multiple passageways and a plurality of channels spaced circumferentially around the central passageway. The device further includes a ring with a plurality of outlets and a plurality of frames coupled to the ring. Each of the plurality of frames includes a frame channel, a frame opening, and a distal end coupled to one of the plurality of outlets. A plurality of supports extend between the cylinder and the plurality of frames, and each of the plurality of supports is coupled to the cylinder with an adjustable lock. Each of the plurality of frames is adjustable with respect to the cylinder in response to movement of the corresponding adjustable lock with respect to the cylinder.

A method for calculating a dose for brachytherapy is disclosed, in which radiation is provided by one or more radiation sources from at least a first dwell position and a second dwell position within a patient. The method includes performing a first dose calculation for the first dwell position according to a first dose calculation algorithm, performing a second dose calculation for the second dwell position according to a second dose calculation algorithm, and using the sum of the first dose calculation and the second dose calculation as a total calculated dose. By combining different dose engines with different characteristics, calculations with sufficient accuracy and good time efficiency can be provided.

The application provides a vagina after-loading guide implant needle treatment device, a production equipment and a production process, and belongs to the technical field of brachytherapy equipment for cervical cancer. The vagina after-loading guide implant needle treatment device comprises a guide main body and a positioning damping sleeve. The guide main body comprises a guide head end, an intermediate cylinder, a tail end cylinder and an extension handle. The positioning damping sleeve is arranged at the front end of the guide head end. A plurality of groups of straight implant needle channels and a plurality of groups of inclined implant needle channels are arranged through the guide main body. The production equipment of the vagina after-loading guide implant needle treatment device comprises a first injection molding device for producing the guide head end and the tail end cylinder and a second injection molding device for producing the intermediate cylinder and the extension handle. Each component is separately injection molded, and the straight implant needle channels and the inclined implant needle channels are demolded. The vagina after-loading guide implant needle treatment device, the production equipment and the production process improve the production efficiency and reduce the production cost.

The invention relates to a metal artifact correction method for a cervical brachytherapy CT image, and the method comprises the following steps: carrying out the metal artifact synthesis processing of a cervical cancer EBRT CT image, and obtaining a synthesized image; constructing a metal artifact correction model; training a metal artifact correction model by adopting the composite image and the original EBRT CT image; performing metal artifact correction processing on the cervical BT CT image by adopting the trained metal artifact correction model to obtain a corrected CT image; according to the method, the artifact image containing the synthetic cavity artifact is simulated and generated from the EBRT CT image, the large-scale synthetic pairing data set is constructed and used for model training, the trained metal artifact correction model is adopted to carry out metal artifact correction processing on the cervical BT CT image, and the metal artifact of the cervical BT CT image can be effectively removed.

The utility model discloses a source application combination device for cervical cancer brachytherapy, and particularly relates to the technical field of medical instruments, the source application combination device comprises an outer sleeve, an inner cylinder frame, an insertion strip, a vaginal orifice fixing piece and an insertion needle, the vaginal orifice fixing piece is sleeved on the outer surface of the outer sleeve, the outer sleeve is sleeved on the outer surface of the inner cylinder frame, and the insertion strip is inserted into the insertion needle. Inserting strip channels corresponding to the inserting strips are formed in the inner cylinder frame, and the inserting strips are inserted into the corresponding inserting strip channels. The insertion strip comprises a treatment insertion strip and a protection lead strip, and the insertion needle is inserted into the treatment insertion strip; a limiting mechanism is arranged between the inserting strip and the inner cylinder frame, and a fixing mechanism is arranged between the implanting needle and the treatment inserting strip. According to the utility model, the outer sleeve and the inner sleeve frame are arranged, and the shape of the end part is utilized, so that the device is better attached to the vagina postoperative stump, and the local treatment advantage of close-range radiotherapy can be better exerted; a transparent material is utilized to realize accurate implantation of the implantation needle, the treatment insertion strip and the protection lead strip; and various treatment requirements of patients are met.