16 results about "External beam radiation" patented technology

An external beam radiation therapy dose prediction system through a latent diffusion model is adapted to predict an external beam radiation therapy plan according to a clinical data of a patient and includes a storage unit adapted to store a training data and the clinical data and a processor signally connected to the storage unit. The training data includes a plurality of medical images, a plurality of dose distribution data, and a plurality of training prompts. The processor is adapted to input the training data to a latent diffusion training model to execute a latent diffusion model training and generate an external beam radiation therapy plan model and input the clinical data and at least one prompt to the external beam radiation therapy plan model to generate an external beam radiation therapy plan.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

Systems, devices and methods for internal dose adapted automated external radiation beam therapy, and systems and methods for an automated adaptive workflow to automatically generate a radiation treatment plan based on the internal dose and adapt the treatment plan to a current treatment session using a set of directives.

The present invention provides a WRN inhibitor for use in the treatment of cancer, in particular microsatellite instability-high (MSI- H) or mismatch repair deficient (dMMR) cancer, wherein the treatment further comprises administration of: A. an ionising radiation-based therapy selected from: i) external beam radiation, ii) brachytherapy and Hi) a radiopharmaceutical, or B. carboplatin and paclitaxel; The WRN inhibitor is a compound of formula (1g) or compound C : Formula (C).

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue invoves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, compact radiotherapy systems are provided that incorporate multi-function components, reducing bot equipment size and expense.

A computer-based method for optimizing a patient's radiation therapy treatment plan is presented, wherein a treatment plan to be provided by one radiation set is optimized taking into account previously delivered doses delivered by different radiation sets, one of the radiation sets being external beam radiation therapy and the other being brachytherapy.

A computerized system (SRS) for radiation therapy support. The system comprises an input interface (IN) for receiving an input image acquired by an imaging apparatus (IA1). The input image represents a region of interest (ROI) internal of a patient (PAT) and acquired before delivery of a dose fraction by a radiation therapy delivery apparatus (RTD). A pre-trained machine learning unit (MLU) of the system is configured to process the input image to detect a medical condition. A communication component (RC) of the system is configured to provide, based on the detected medical condition, an indication for one or more clinical actions to be performed in relation to the patient.

Systems, devices and methods for internal dose adapted automated external radiation beam therapy, and systems and methods for an automated adaptive workflow to automatically generate a radiation treatment plan based on the internal dose and adapt the treatment plan to a current treatment session using a set of directives.

A method of trajectory optimization for radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining one or more optimal treatment trajectories based on the BEV region connectivity manifold.

A computer-based method of optimizing a radiotherapy treatment plan for treating a patient involving radiation being delivered by a beam describing an arc is defined, the method including defining at least a first and a second part of the arc, the first part being a first sector of the arc and the second part being a second sector or a static beam, obtaining an optimization problem including at least a first optimization function for the first part, and a second optimization function for the second part and optimizing the radiotherapy treatment plan based on the optimization problem.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

Various embodiments of the present technology are generally related to a multimedia distraction system for patients receiving external beam radiation therapy. More specifically, some embodiments relate to a system for providing a video image to a patient while undergoing a treatment to avoid the need to anesthetize. The system comprises a video image source, a projector communicatively coupled to the video image source, abeam expander coupled to the projector, and a screen transparent to the radiation beam used in a radiation therapy treatment. The present technology can be used to distract a patient during multiple types of external beam radiation therapy including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, volumetric modulated arc therapy, and non-coplanar arcs, without interfering with the treatment.

The present invention provides pharmaceutical combinations comprising a WRN inhibitor for the treatment of cancer, wherein the treatment further comprises administration of an ionising radiation-based therapy selected from external beam radiation, brachytherapy and a radiopharmaceutical, or further comprises a combination of carboplatin and paclitaxel.

Systems, devices and methods for augmented reality guidance of imaging systems, external beam radiation systems, and detector plates are described.

In one embodiment, a prostate cancer patient can be treated with several novel approaches to bipolar androgen therapy. According to various embodiments, a combination of external beam radiation with bipolar androgen therapy can be used. According to various embodiments, one or more of intravenous injection, transdermal application and / or buccal administration of testosterone can be used to significantly decrease the length of time spent tapering between supraphysiologic and castrate levels of testosterone.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined, multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).