23 results about "Neutron capture" patented technology

An arylboron compound, its preparation method, applications, and pharmaceutical compositions are disclosed for tumor imaging. The compound of formula (I) exhibits high fluorescence quantum efficiency through intramolecular charge transfer. The compound of formula (I) synthesized in this invention can be linked to different antibodies via Q3 at certain concentrations, allowing for precise targeting of corresponding tumors based on the antibody. This type of boron drug formulation can be used in boron neutron capture therapy to kill tumor cells. It exhibits better killing effects; the compound of formula (I) targets tumor cells through antigen-antibody interaction. After the boron-10-containing drug accumulates at the tumor site, neutron radiation triggers a nuclear reaction releasing alpha particles and... 7 Lithium particles kill cells; the range of these two particles is approximately 10 μm. High-energy-density heavy ions disrupt the DNA double helix structure in tumor cells, causing irreparable cell death. Simultaneously, the 10 μm distance avoids damage to normal cells and tissues.

The present disclosure provides a neutron target device for boron neutron capture therapy, comprising: a container having a containing cavity; a neutron target component arranged in the containing cavity, the neutron target component comprising a target disc and a target sheet detachably connected with the target disc; a rotating component connected with the target disc for driving the neutron target component to rotate; a driving component connected with the rotating component for driving the rotating component to rotate; and a cooling component arranged at an end of the rotating component away from the neutron target component for supplying a cooling liquid; wherein the rotating component is provided with a liquid inlet cavity and a liquid outlet cavity, the target disc is provided with a liquid inlet flow channel and a liquid outlet flow channel, and the target sheet is provided with a liquid inlet hole and a liquid outlet hole; the liquid inlet flow channel is in communication with the liquid inlet cavity and the liquid inlet hole, and the liquid outlet flow channel is in communication with the liquid outlet cavity and the liquid outlet hole. The flow path structure of the neutron target device of the present disclosure is conducive to improving the cooling rate of the target sheet; and the target sheet is detachably connected with the target disc, which is conducive to the convenience of replacing the target sheet.

This invention relates to the field of nuclear radiation detection technology and discloses a two-dimensional array detector for measuring the spatial distribution of neutrons and photons. The detector body includes a detector body comprising a detection unit layer, a light guide layer, and a readout layer. The detection unit layer, light guide layer, and readout layer are vertically stacked sequentially from top to bottom to form a three-layer modular integrated structure. The layers are precisely mechanically aligned and optically coupled without air gaps. The light guide layer is composed of an array of multiple optical fibers. The detection unit layer is composed of an array of multiple detection units, with each detection unit corresponding to one optical fiber. This invention offers advantages such as modularity, high spatial resolution, and real-time signal processing. It can be applied to the measurement of the spatial distribution of neutrons and photons in the field of boron neutron capture therapy, meeting the practical needs of online real-time measurement of the spatial distribution of the neutron-photon mixed radiation field and accurate verification of the treatment irradiation field dose in boron neutron capture therapy.

Provided are a beam shaping device (10), a neutron capture therapy system (20), and a moderator auxiliary mounting system (30), relating to the technical field of medical equipment. The beam shaping device (10) comprises a moderator assembly (100) and a fixing mechanism (300). An accommodating cavity (200) is formed in the beam shaping device (10), and the moderator assembly (100) is disposed in the accommodating cavity (200). The moderator assembly (100) is configured for adjusting the energy of a neutron beam, and the fixing mechanism (300) is configured for fixing the moderator assembly (100) in the accommodating cavity (200). The mounting stability of the moderator assembly (100) in the accommodating cavity (200) is ensured, and the structural stability of the beam shaping device (10) is improved, such that the beam shaping device (10) can be applied in a vertical irradiation chamber (642).

This invention discloses a front-end interaction and clinical safety control method and system for boron neutron capture therapy, comprising the following steps: constructing a patient-specific treatment model; during treatment, collecting real-time monitoring data streams containing boron concentration data and physiological state signals through biosensors; inputting the monitoring data streams into the patient-specific treatment model to predict future outcomes; based on the prediction results, generating evaluation results in real time through a dynamic optimization algorithm; arbitrating real-time control commands and physiological state signals for safety, and ultimately controlling the treatment execution device; and displaying the real-time monitoring data streams, prediction results, control commands, and safety status through a unified interactive interface. This invention achieves continuous and prospective prediction of boron drug distribution and radiation dose by constructing a treatment model that integrates the patient's unique anatomical and physiological information and dynamically driving the model using real-time collected in vivo data.

The beam parameter measurement device for boron neutron capture therapy provided in this application includes: a detector; a beam inlet window provided on the side of the test chamber facing the beam outlet, with the detector head extending into the interior of the test chamber; a moving mechanism on which the detector is mounted for adjusting the position of the detector head inside the test chamber; an adjustment mechanism on which the test chamber is mounted for adjusting the position of the test chamber to make the geometric center of the test chamber coincide with the center of the beam; and a control system including a data acquisition module and a motion control module. The data acquisition module is electrically connected to the detector for acquiring beam data output by the detector, and the motion control module is electrically connected to the moving mechanism and the adjustment mechanism for controlling the moving mechanism and the adjustment mechanism. This application can reliably adjust the position of the detector inside the test chamber, and can also adjust the position of the test chamber to ensure that the geometric center of the test chamber coincides with the center of the beam, thereby improving the accuracy of the measurement data.

The present disclosure provides a neutron target module for boron neutron capture therapy, comprising: a neutron target substrate, comprising a substrate and a target layer arranged on one side of the substrate; a container connected to a first side of the neutron target substrate, the container having a vacuum cavity, and the target layer is opposite to the vacuum cavity; and a water cooling plate connected to a second side of the neutron target substrate, the water cooling plate is detachably connected to the neutron target substrate, and the water cooling plate is internally configured with an inlet flow channel and an outlet flow channel, and the water cooling plate is used for cooling the neutron target substrate. The neutron target module of the present disclosure is provided with a container and a water cooling plate on the opposite sides of the neutron target substrate, the cooling flow channel in the water cooling plate and the vacuum cavity are isolated from each other, which can effectively prevent the cooling liquid from leaking into the vacuum cavity, and ensure the safety in use. In addition, the water cooling plate is detachably connected to the neutron target substrate, and by replacing the water cooling plate, it is convenient to realize the multiple cooling requirements of the neutron target substrate.

This invention discloses a near-infrared anthocyanin derivative based on boron cluster modification. The anthocyanin unit in the molecular structure of this derivative serves as a near-infrared fluorescence imaging and photothermal conversion unit, possessing not only near-infrared fluorescence imaging capabilities but also the ability to target tumor cells via an organic anion transport peptide-mediated pathway, enhancing selective accumulation in cancerous tissue. The nested carborane structure in the anthocyanin derivative molecular structure utilizes its strong electron-donating properties to induce photo-induced electron transfer with the anthocyanin unit, significantly improving photothermal conversion efficiency while reducing fluorescence quantum yield. The resulting molecule possesses tumor targeting, near-infrared imaging capabilities, and highly efficient photothermal and boron neutron capture therapy functions, achieving synergistic diagnostic and combined therapeutic effects of boron neutron capture therapy (BNCT) and photothermal therapy (PTT) in a single system.

A neutron flux detector comprising a source material and a solid state radiation detector is disclosed. The source material is configured to produce gamma photons greater than or equal to 6.8 MeV during neutron capture. The solid state radiation detector comprises a Schottky diode and an emitter layer comprising a Compton and photoelectron source material. The emitter layer is configured to receive the gamma photons produced by the source material. The emitter layer is spaced apart from the Schottky diode a distance such that a gap is defined between the emitter layer and the Schottky diode. The distance is selected such that only electrons produced by the emitter layer as a result of the emitter layer absorbing the gamma photons will contribute to a measured output signal of the Schottky diode.

Compounds, compositions, and methods for use in boron neutron capture therapy are disclosed.

Intact bacterial vesicles are highly effective for in vivo delivery of boron for radiotherapeutic purposes, as in boron neutron capture therapy. A compound comprising a boron isotope, such as boron-10 or boron-11, can be joined chemically to a fluorescent moiety to produce a molecule that can be loaded stably into bacterial vesicles, which when coated with an appropriately targeting bispecific antibody can deliver boron specifically into tumor cells in an amount enabling boron-mediated radiotherapy that eliminates tumor cells with minimal damage to adjacent normal cells.

The present disclosure provides a neutron target structure and a neutron target device for boron neutron capture therapy, the neutron target structure comprising: a target disc provided with an inlet flow channel and an outlet flow channel; a target sheet provided with an inlet hole and an outlet hole; and a quick connector assembly comprising a first quick connector and a second quick connector connected by a plug connection, the quick connector assembly being used to connect the inlet hole and the inlet flow channel and to connect the outlet hole and the outlet flow channel, so that the target sheet is detachably connected with the target disc. The neutron target structure of the present disclosure, the quick connector assembly comprising a first quick connector and a second quick connector connected by a plug connection, the inlet flow channel and the outlet flow channel of the target disc being connected with the first quick connector, the inlet hole and the outlet hole of the target sheet being connected with the second quick connector, the target sheet being connected with the target disc through the two quick connector assemblies, which is conducive to the convenience of installation and disassembly, and further conducive to the convenience of replacement.

This invention belongs to the field of medical devices and discloses an infusion device for boron neutron capture therapy. The infusion device is used to deliver boron drugs into the patient's body. The infusion device includes a triangular base and a control box. In use, this invention constructs a three-level protection mechanism through the coordinated work of a storage component, a fixing component, and a pressure relief component. This avoids the risk of pulling at the source, buffers small pulling forces, and cuts off the transmission of large pulling forces, completely solving the problem of needle dislodgement caused by patient movement or accidental collisions during BNCT treatment. The storage component uses partitions and anti-slip rolls to orderly store the tubing and avoid tangling. The fixing component uses a 360° rotating connecting rod to convert linear pulling force into rotational motion, buffering small impacts. The pressure relief component uses mechanical linkage to release pressure, separating the device from the ground and cutting off the transmission of large pulling forces to the needle, ensuring treatment continuity and patient safety.

The utility model discloses a composite boron neutron capture therapy neck directional radiation protection neck warmer, including the rear neck protection cover of the open rear end along the axial arrangement, the lower extreme of rear neck protection cover is provided with the extension, and the bottom of rear neck protection cover is connected with the shoulder of the extension through the extension, the opposite opening both sides of rear neck protection cover are provided with medical grade magic tape respectively, and the other end of medical grade magic tape is connected with neck warmer protection block, and the inside of neck warmer protection block is provided with the neutron absorption layer for reducing the radiation damage of thyroid part to neutron and the secondary ray shield layer for shielding the secondary photon of neutron protection process. The utility model solves the problem that the weight of protection instrument is big, and the problem that wearing does not fit the neck of patient in the prior art.

This invention discloses a device, method, and system for synergistic regulation of flux and energy spectrum in boron neutron capture therapy (BNCT), belonging to the field of radiotherapy technology. It includes a composite modulation unit array, comprising multiple composite modulation rods capable of independent linear motion along a direction parallel to the beam axis. Each composite modulation rod is composed of at least two segments of neutronic materials with different neutron reaction cross sections and moderation capabilities, fixedly connected along its direction of motion. By employing an array of independently linearly moving composite modulation rods, and ensuring that each rod is composed of at least two different neutronic material segments, this invention breaks the traditional paradigm of separating flux regulation and energy spectrum regulation. It achieves synchronous, independent, and dynamic integrated modulation of the flux intensity and energy spectrum characteristics of the output neutron beam in any local region of two-dimensional space, thereby achieving dual optimization of dose and biological effects, significantly improving the personalization level and potential efficacy of BNCT treatment.

The present application relates to a kind of high-efficiency heat dissipation neutron target device for electron accelerator boron neutron capture therapy, it includes: electron beam control system, beam transmission vacuum pipeline, heavy water chamber, composite target, neutron beam reflector, shielding body and neutron beam slowing shaping body, wherein, electron beam control system is expanded to beam or the way of electron beam scanning is expanded to beam cross-sectional area;Beam transmission vacuum pipeline small diameter end is connected to the connecting flange of electron accelerator beam outlet;Heavy water chamber contains circulating heavy water;Composite target includes X-ray conversion target and high-efficiency heat exchange base, and the side of high-efficiency heat exchange base facing heavy water is provided with cooling array flow-through heavy water, increase the area of contact with circulating heavy water, increase the heat dissipation efficiency;Neutron beam reflector reflects the neutron emitted in different directions to the predetermined neutron beam exit;Shielding body, neutron beam is collimated to the shape and size required for treatment;Neutron beam slowing shaping body carries out neutron beam in exit slow spectrum shape optimization.

Disclosed are compounds, compositions, and methods useful for boron neutron capture therapy.

This invention discloses an online dose monitoring and alarm system and method for boron neutron capture therapy, belonging to the field of radiation dose monitoring technology. It includes at least one set of integrated wireless monitoring probes and a central monitoring platform. The system highly integrates a radiation detection module, a photoelectric conversion module, a high-speed analog-to-digital / digital-to-analog conversion module, an FPGA module, a wireless communication module, and a built-in lithium battery. The FPGA executes a shape discrimination algorithm based on the difference between pulse rise time and / or decay time at the probe end using hardware logic to distinguish neutron / gamma events and calculate the count rate and dose rate in real time. When the monitored value exceeds a preset safety threshold, the high-speed digital-to-analog conversion module drives an LED indicator and / or a buzzer to issue a local audible and visual alarm. Compared with existing technologies, this invention achieves synchronous real-time monitoring of neutron flux and gamma dose, improves alarm response speed, facilitates flexible deployment near the treatment head or patient irradiation field in space-constrained locations, and enhances the safety and accuracy of treatment.

The present disclosure provides a neutron therapy system for boron neutron capture therapy, comprising: a reflector provided with a containing cavity for containing a neutron target module; a moderator module arranged in the reflector and located on one side of the neutron target module; a filter arranged in the reflector and located on a side of the moderator module away from the neutron target module; and a collimator arranged on a side of the filter away from the moderator module; wherein the reflector comprises a detachably connected reflection seat and a reflection cover, so that the moderator module is detachably connected to the reflector. The neutron therapy system of the present disclosure has the advantages of convenient replacement and low maintenance cost, because the reflection cover is detachably connected to the reflection seat and can be removed to replace the moderator module.

This invention relates to a high-energy electron accelerator device capable of performing flash radiotherapy and boron neutron capture therapy (BNCT), comprising: a high-energy electron accelerator for providing a high-energy, high-power electron beam; an automatic beam duty cycle control system for precisely controlling the beam duty cycle of the accelerator to meet the dual-function requirements of flash radiotherapy and BNCT; at least one flash radiotherapy end for flash radiotherapy, converting the electron beam provided by the high-energy electron accelerator into an X-ray beam or electron beam required for treatment; and at least one BNCT end for boron neutron capture therapy, converting the electron beam provided by the high-energy electron accelerator into an ultrathermal neutron beam required for treatment. Multiple electron accelerators can be drawn from different locations of the high-energy electron accelerator or connected in series according to the energy requirements of the flash radiotherapy end and the BNCT end, achieving the high-energy electron beam requirement of tens of MeV. Depending on the needs of tumor treatment, flash radiotherapy or boron neutron capture therapy can be selected, or flash radiotherapy and BNCT can be performed simultaneously through beam splitting.

The application discloses a kind of boron neutron capture therapy beam gamma dose measurement methods, it is related to radiotherapy technical field, first thermoluminescence dosimeter is standardized annealing pretreatment, and screening, numbering;Positioning and calibration are carried out to water equivalent phantom fixed on treatment bed, complete reference positioning;Thermoluminescence dosimeter is loaded in water equivalent phantom and is irradiated again;After irradiation, take out phantom, establish the one-to-one correspondence between unique number and its three-dimensional space position in phantom, and record;First measurement and second measurement are carried out to all dosimeters in turn, calculate thermoluminescence net gamma count, obtain absorbed dose value;Thermoluminescence dosimeter is annealed again, for subsequent circulation use conveniently.The application in the application multiple thermoluminescence dosimeters are irradiated simultaneously, shorten time;Two independent measurements, deduct interference signal;Complex operation process standardization, programming, improve measurement repeatability and efficiency, convenient, novel, accurate.

This invention discloses a patient fixation device and positioning method for boron neutron capture therapy, belonging to the field of surgical medical device technology. It includes a positioning plate, a head positioning plate, and a connector between the positioning plate and the head positioning plate. The two edges of the positioning plate taper inward at corresponding shoulder positions to form a shoulder avoidance structure. The patient fixation device also includes a posture monitoring unit and an adjustment data display unit. The posture monitoring unit is used to monitor the spatial position of the head positioning plate in real time. This invention forms a closed-loop control mechanism through the posture monitoring unit and the adjustment data display unit, monitoring the spatial pose of the head positioning plate in real time during treatment and automatically performing dynamic compensation when minute displacements occur, ensuring that the patient's target area is always accurately maintained in the preset treatment position. High-precision pose maintenance improves the accuracy of dose delivery, thereby comprehensively improving the treatment efficiency and clinical efficacy of boron neutron capture therapy.