8 results about "Dual target" patented technology

The present invention relates to a dual-target double-stranded RNA for treating hepatitis B, and a pharmaceutical composition. The dual-target double-stranded RNA comprises a first double-stranded RNA and a second double-stranded RNA, wherein one of the first double-stranded RNA and the second double-stranded RNA targets the hepatitis B virus (HBV) life cycle, and the other targets a host immune target PD-L1. The double-stranded RNA can simultaneously target the dual targets of HBV and host immune PD-L1, which can inhibit HBV replication while activating human immunity, and is therefore expected to bring about a clinical functional cure.

The application discloses a kind of dual-target collaborative multi-satellite resource allocation methods based on spatial dispersion, effectively solve the problem of inconsistent specification in capability description, difficult calculation in multi-satellite resource allocation under large-scale remote sensing satellite scene.The method comprises the following steps: first, the earth surface is dispersed into grid, precalculates satellite coverage capability and is mapped to grid, realizes uniform description of coverage capability;Second, a satellite coverage capability master table is constructed with grid code as the primary key, for efficient retrieval;Finally, based on the master table, with optimal task completion time as the main target, the lowest energy consumption as the secondary target, the task completion time is compressed through time optimization stage, the total energy consumption is reduced under time constraint in energy consumption optimization stage, and the conflict of dual targets is balanced by means of dynamic relaxation mechanism, to generate multiple optimization schemes, realize the efficient allocation of large-scale remote sensing satellite resources.

The invention discloses a double-target positioning and closed-loop tracking system and method based on color feature recognition, belongs to the field of target recognition, and aims to solve the problems of low relative positioning precision, poor closed-loop tracking stability and weak color feature anti-interference capability in the prior art. The system comprises a PC, an STM32 controller, a camera, a stepping motor module, a two-dimensional mobile platform, a power supply module and a target. Wherein the STM32 controller is respectively connected with the stepping motor module and the PC; the PC is connected with the camera; the stepping motor module is connected with the two-dimensional moving platform, and the power module is connected with the STM32 controller and the stepping motor module and supplies power to the STM32 controller and the stepping motor module. The camera is used for collecting an image and identifying and positioning a target by adopting an identification algorithm based on the image, the two-dimensional mobile platform is used for tracking the target by adopting a tracking algorithm, and the positioning precision, the tracking stability and the anti-interference capability are improved.

The invention discloses a compound with anti-psoriasis activity and double-target inhibition, and the structural general formula of the compound is shown in the specification. The compound with anti-psoriasis activity and double-target inhibition provided by the invention has good efficacy on in-vitro anti-psoriasis related tests and in-vivo imiquimod induced mouse models; the compound H7e shows better anti-psoriasis activity than their parent drugs and combined administration of the parent drugs.

This invention discloses a dual-mechanism coupled dual-target PFAS simultaneous quantitative colloidal gold test strip, reagent kit, and detection method, belonging to the field of colloidal gold immunochromatographic detection technology. The test strip of this invention adopts a dual-channel structure coupled with a competition-capture dual-mechanism, carrying a dual-site specific gold affinity complex. The dual-channel chromatography kinetics are synergistically matched through membrane pore size and spraying amount control, and a dual-stage quality control line ensures detection effectiveness. The reagent kit includes the test strip and special components such as centrifugation-free extraction solution and dual-target diluent, suitable for on-site scenarios without centrifuges or cold chains. The detection method is simple to operate, and a single test can achieve simultaneous quantification of PFOA and PFOS. The sensitivity and accuracy of low-concentration detection are significantly improved, making it suitable for large-scale mass production and rapid on-site screening of environmental water samples, filling the technical gap in the simultaneous and accurate detection of dual targets of PFAS.

The invention provides a salvia miltiorrhiza yield-quality double-target prediction method based on a multi-source remote sensing image. The method comprises the following steps: acquiring and preprocessing an original optical remote sensing image and an original synthetic aperture radar image in a growth period of salvia miltiorrhiza in a target area to obtain a first optical remote sensing image and a first synthetic aperture radar image; performing structural feature enhancement on the first optical remote sensing image by using a multi-attribute constrained image enhancement diffusion model to obtain a second optical remote sensing image; detecting the key growth period of salvia miltiorrhiza based on the first synthetic aperture radar image and the second optical remote sensing image; taking the first synthetic aperture radar image and the second optical remote sensing image corresponding to the key growth period of salvia miltiorrhiza as the input of the multi-mode spectrum-structure inversion model, and predicting the content of effective components of tanshinone IIA and salvianolic acid B and the plant yield; evaluating the content of effective components of tanshinone IIA and salvianolic acid B and the plant yield, and outputting a salvia miltiorrhiza yield-quality estimation map and a grade distribution map of the target area.

The application discloses a dual-target azimuth aiming measurement system, comprising an optical path module, an azimuth information measurement module and an aiming module, wherein the optical path module comprises a first optical path for equating a high-position dual target to a dual equivalent target and a second optical path for realizing optical transmission between a north reference and the dual equivalent target; the azimuth information measurement module is used for providing north azimuth information to the aiming module in real time after initial alignment of the north azimuth; and the aiming module is used for aiming based on a preset aiming procedure according to the north azimuth information of the azimuth information measurement module, so as to obtain the north azimuth information of the high-position dual target. The application replaces a serial working mode of a conventional single-target aiming mode of searching north first and aiming later, solves the problem that the north searching measurement time influences aiming rapidity, realizes rapid and high-precision measurement of dual-target azimuths with large height difference, and has the capability of long-term duty and rapid and automatic completion of target azimuth measurement.

The present invention provides a diaryl compound as a tubulin / Src dual target inhibitor. The present invention also provides a diaryl compound represented by formula I, a tautomer, a stereoisomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof. The diaryl compound can be used as a dual target inhibitor against tubulin and Src kinase, and can also be used as a mono-target inhibitor against tubulin or Src kinase. The compound of the present invention can significantly inhibit the polymerization of tubulin monomers and cell proliferation.