238 results about "Dual target" patented technology

The invention discloses a dual target liposome and a preparation method and application thereof. The target liposome provided by the invention consists of liposome and modifiers on the surface of the liposome, wherein the modifiers on the surface of the liposome comprise p-aminophenyl-alpha-D-manno-pyranoside and transferrin. The invention also discloses a medicament-loaded liposome, which is obtained by wrapping daunorubicin by using the target liposome. The obtained target liposome has good capability of crossing the blood brain barrier, targets brain glioma, and can be used as a medicament carrier. The medicament-loaded liposome can target the medicament to a brain glioma site after crossing the blood brain barrier so as to greatly increase the concentration of the medicament at a tumor site and improve the effect of chemotherapy. The target liposome provides a new measure for brain glioma chemotherapy, contributes to the research of non-invasive therapy of the brain glioma, and has important theoretical meaning and clinical meaning.

The invention discloses an NAMPT/HDAC dual-target inhibitor and a preparation method thereof. The dual-target inhibitor is an amide derivative and pharmaceutically acceptable salt thereof, wherein a structure general formula is represented as the formula (I). A pharmacological experiment proves that the derivative or the salt thereof have very strong inhibition activity on the nicotinamide phosphoribosyl transferase and the histone deacetylase, and have high in-vitro anti-tumor activity and excellent in-vivo tumor inhibiting effect. The invention also provides a preparation method of the derivative and the pharmaceutically acceptable salt thereof, and an application in preparation of an NAMPT inhibitor, a HDAC inhibitor, and anti-tumor medicines.

The present invention relates to: a dual targeting antibody of a novel form having a water-soluble ligand fused to the N-terminus of a heavy chain or light chain of an antibody; a DNA encoding the dual targeting antibody; a recombinant expression vector containing the DNA; a host cell which is transformed with the recombinant expression vector; a method for preparing the dual targeting antibody by culturing the host cell; and a pharmaceutical composition including the dual targeting antibody.

This invention relates to adaptive resistance inhibiting 100 to 10,000 Gy, single fraction proton and carbon ion microbeam and nanobeam radiosurgery, proton spray chemotherapy and proton spray gadolinium and boron neutron capture therapy with least normal tissue toxicity. Secondary neutrons, protons, ions and radiation from the accelerator and the patient specific collimator are removed with tissue equivalent collimator that also generates proton and carbon ion microbeam and nanobeam. Laser interaction with micrometer and nanometer thick metallic and diamond like carbon targets are also used for proton and carbon ion beam generation. Polyenergetic proton beam is spatially separated. Ion beam and Laser ion beam is accelerated in a hybrid RF accelerator. It is split into microbeam and nanobeam. Secondary neutrons, protons and gamma radiation are removed with tissue equivalent collimators that also generate microbeams and nanobeams. Adaptive resistance to cancer treatment is inhibited by dual target radiation, DNA strands break and enzymes inactivation.

The invention relates to a dual-target positioning method for a simulated medical instrument and a virtual simulation medical teaching system. The dual-target positioning method comprises: an instrument is associated with a feature target; cameras are configured and an overlapped view area between two cameras is adjusted; calibration is carried out; to be specific, the cameras obtain images of a calibration reference object and internal and external parameters of the cameras are calculated; correction is carried out; to be specific, distortion elimination and row alignment are carried out on aleft view and a right view respectively according to the internal and external parameters obtained after camera calibration, so that antipode lines are aligned in rows; instrument capturing is carried out; to be specific, a feature target is captured to capture an instrument; and three-dimensional matching is carried out; to be specific, three-dimensional matching is carried out based on a mapping relationship and distortion is corrected, and a spatial position of the instrument is calculated in real time. According to the invention, only a designated feature target needs to be pasted to thesurface of a medical instrument and no other object connection is needed, so that the portability is improved substantially and the simulation degree is increased; the moving area is adjusted by adjusting the cameras, so that the operating area is increased greatly; and a plurality of medical simulation instruments can be identified simultaneously.

The invention provides a preparation method of a target compound nano particle, relating to a preparation method of target treatment integration compound nano particles. The invention solves the technical problems of poor carrier stability and small drug-loading quantity of the traditional antineoplastic drugs. The method comprises the following steps of: preparing a methanol solution of an integrated nano particle of a Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer; and stirring the methanol solution of the integrated nano particle of the Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer, N,N-dimethylformamide and target biomolecule or antitumor drug for reacting at the room temperature, and centrifuging to obtain the target compound nano particle. Polystyrolsulfon acid (PSS) and 10-hydroxycamptothecine are absorbed on a Fe3O4 magnetic nano particle through a self-assembly mode. The preparation method is high feasibility; the target compound nano particle has a physical target function of the magnetic nano particle and an active target function of further functionally modifying the biomolecule on the surface; and the medicine concentration can be increased under a dual-target function.

The invention relates to dual-targeting ursolic acid (UA)/siRNA loaded fluorescent mesoporous silica dioxide-hyaluronic acid and application. The technical scheme of the invention lies in that 1, fluorescently-labeled mesoporous silica dioxide nano particles are synthesized through the template method; 2, the surface of FMSN is subjected to amino modification through 3-aminopropyltriethoxysilane; 3, ursolic acid (UA) and siRNA are jointly loaded into porous channels of the nano particles; 4, hyaluronic acid is loaded into the outer surfaces of the nano material in a wrapping manner through electrostatic absorption, so as to obtain the dual-targeting ursolic acid (UA)/siRNA loaded fluorescent mesoporous silica dioxide-hyaluronic acid nano particles. According to the dual-targeting ursolic acid (UA)/siRNA loaded fluorescent mesoporous silica dioxide-hyaluronic acid and application, the prepared nano material is uniform in particle size distribution, and good in dispersibility, the stability of siRNA can be improved, and besides, siRNA can further specifically target tumor cell surface adhesion molecules like ICAM and CD44, therefore the anti-tumor effect of drugs can be greatly improved, and the toxic and side effect of the drugs can be further reduced.

The invention relates to a coating and the preparation method of the coating. The AlN / Si3N4 nano-multi-layer film of the invention, which is formed by AlN and Si3N4 on a metal or ceramic substrate, is a multi-layer structure of the alternating deposition nano meter level. The thickness of each layer ranges from 0.4 to 12.0 nm, and total thickness ranges from 1.0 to 5.0 micron. When in preparing, firstly, the surface of the metal or ceramic substrate can be polished to a mirror surface; and then, the layers of Si3N4 and the layers of AlN can be alternately deposited by using pure targets of Al and Si to conduct the dual-target RF reactive sputtering on the metal or ceramic substrate; finally, the nano-multi-layer film AlN / Si3N4 can be obtained by inletting Ar and N2 which are both in high-purity. The thickness of the nano-multi-layer film AlN / Si3N4 can be achieved by increasing the preparing cycle of the multi-layer film. The maximum hardness of the nano-multi-layer coating is 37.8 GPa, which significantly is higher than the material used for preparing the coating; the nano-multi-layer film AlN / Si3N4 provided by the invention can achieve higher production efficiency.

The invention discloses an infrared and visual light combined guidance semi-physical simulation method. The method includes the following steps that an infrared and visual light combined simulation system is built; a dual-target load type five-axis rotary table overall structure is determined; the layout and load installing mode of the infrared and visual light combined simulation system are determined; infrared and visible light double wavebands operate in a segments in a combined mode. The infrared and visual light combined guidance semi-physical simulation method effectively meets the requirement of large-diameter infrared and visual light combined seeker double waveband segmented combined guidance semi-physical simulation tests.

The present invention relates to dual-targeting cytotoxic compounds of formula (I) and to their preparation. The described compounds are endowed with tumour specific action, incorporating three functional units: a tumour recognition moiety and a tumour selective enzymatic substrate sequence connected together by means of a spacer. These conjugates are designed to guarantee serum stability and, at the same time, the desired action inside the tumour cells as a result of enzymatic cleavability. [(L-D)_nE]_m-F-D-PI-SI-CT Formula (I).

The invention relates to a preparation method of a dual-targeting drug carrier based on a magnetic metal organic framework material, belonging to the technical field of preparation of bio-medicinal functional materials. The preparation method comprises the following steps: firstly, modifying ferroferric oxide to form dopamine-wrapping ferroferric oxide, and preparing the dual-targeting drug carrier based on the magnetic metal organic framework material by taking dopamine-wrapping ferroferric oxide (Fe3O4@PDA) as the matrix material; and carrying out a series of treatment to obtain an adsorbent, and carrying out selective recognition and separation on adriamycin in an aqueous solution by adopting the adsorbent. The dual-targeting drug carrier based on the magnetic metal organic framework material prepared by adopting the method provided by the invention has good heat stability and very large medicine-carrying capacity, has the acid-base effect, and also has the function of controlling medicine release.

A cubic electrode is made up of base material, cubic structure and catalytic activate materials, the cubic structure material is composed of column, ball or un regular particles from millimicron-micron, combined or adhered to the base material with short distance capillary channel and gas breath structure favourable to methyl alcohol siphon characterizing in high pore space retion and rough surface. It's real surface area is far large than its own geometrical area and catalytic active to methyl alcohol. The cubic structure of electrode is built with electric chemical method reaching dual targets with cubic structure and catalytic active.

The invention discloses Topology shape design method for partition machining track on curved surface based on vector field, and belongs to the technical field of high precision and high efficient milling machining of complex curved parts, and relates to a topology shape design method for partition machining track on curved surface based on vector field. The method comprises the steps of: establishing a feeding vector field with a cooperation constraint of a chord height error and a residual error, constructing a normalized dual target optimization model with two types of error, solving optimalfeeding direction of each point through an evaluation function, and establishing a space vector field; calculating a divergence and a rotation of a plane vector field after projection, and realizinginitial segmentation of the machining region according to whether the divergence and the rotation of the plane vector field are zero or not; analyzing different vector field features, fitting spatialvector field streamlines, calculating motion parameters of feeding motions of a machine tool rotating shaft along deformation lines, and completing machining region partition according to whether theparameters are mutated or not; and realizing the topology shape design of partition machining track on curved surface in combination with a feeding mode. The topology shape design method for the partition machining track on the curved surface based on the vector field is suitable for complex curved surface partition machining, can reduce machining errors, and improves motion smoothness of feeding.

A real-time measurement method of pupil diameters based on the binocular stereo vision is provided. The method comprises: using Zhang Zhengyou's dual target method for camera calibration to obtain a rotation matrix, a translation matrix, a parameter matrix in the left industrial camera, and a parameter matrix in the right industrial camera; respectively processing images captured by the left industrial camera and the right industrial camera to obtain true ellipses corresponding to the pupil; drawing a straight line across the center of the true ellipse of the pupil obtained by the left industrial camera, wherein the straight line equation is intersected by the true ellipse of the left industrial camera to obtain a first intersection point and a second intersection point; according to the principle of polar line constraint and order consistency, by using the first intersection point and the second intersection point, respectively solving a first matching point and a second matching point corresponding to the two intersection points on the true ellipse obtained by the right industrial camera; and obtaining preliminary values of a plurality of pupil diameters corresponding to a plurality of straight lines with different slopes, and solving an average value to obtain a final result. The method provided by the present invention has high measurement precision, does not require the worker to fix the working distance, and has great application value.

A vanadium oxide thermo-sensitive film material with a high temperature coefficient of resistance (TCR) contains a rare earth element of Yttrium serving as a dopant in a preparation process. The vanadium oxide thermo-sensitive film material includes a substrate and a yttrium-doped vanadium oxide film layer. The yttrium-doped vanadium oxide film layer includes three elements of vanadium, oxygen and yttrium, wherein the atomic concentration of yttrium is at a range of 1%-8%, the atomic concentration of vanadium is at a range of 20-40% and the residue is oxygen. The method for preparing the vanadium oxide thermo-sensitive film material with high TCR includes a reactive magnetron sputtering method using a low-concentration yttrium-vanadium alloy target as a sputtering source or a reactive magnetron co-sputtering method using dual targets including a high-concentration yttrium-vanadium alloy target and a pure vanadium target as a co-sputtering source.

The invention provides a tumor dual target liposome mediated by integrin and a preparation method thereof. The composition of the invention comprises the components of an antitumor medicament, polypeptide with tumor new vessel target function and tumor cell target function, polyethylene glycol and derivates thereof and a vector for preparing liposome medicaments.

The invention discloses a dual-target direct equalization circuit of a battery pack. A series battery pack comprises at least three single batteries and is divided into an upper part and a lower part,each single battery is connected with an equalization sub-circuit, the equalization sub-circuit comprises two metal-oxide-semiconductor field-effect transistors (MOSFETs) and an energy storage inductor, the series battery pack and the equalization sub-circuit bridge between VCC and GND, each equalization circuit is also connected with a control circuit to achieve direct equalization on an equalization target, the control circuit is used for equalizing end voltages and SOC of the single batteries in a stage way within an equalization period by simultaneously taking the end voltages and the SOCof the single batteries as equalization indexes, and dual-target equalization on the end voltages and the SOC of the single batteries is achieved by controlling on/off of the two MOSFETs of the equalization sub-circuit and by an energy storage effect of the energy storage inductor. The equalization circuit and an equalization strategy are applicable to an equalization management system of an energy storage device in a hybrid electric vehicle, a blade electric vehicle and an energy storage power station.

The invention discloses a system and a method for precisely identifying a target and calculating an effect in an ecological sponge type urban construction suitable area. The system comprises a spatialdata acquisition module, a suitable area spatial identification module, an index control and measure design module and a construction effect calculation module. The method is used for sponge city construction from city construction planning to engineering design whole process. Accurate identification of construction and reconstruction target suitable areas and suitable grade targets in urban heatisland control and urban landscaping processes can be realized, and the effects of flood disasters and high-temperature extreme climate events under different urban construction and reconstruction scenarios can be measured and calculated. The system comprises a novel sponge city and heat island control dual-target city planning and design framework, achieves refined remote sensing classificationand artificial intelligence detection algorithm aiming at precise identification of the ecological sponge city space suitability, and can effectively simulate the effects of city construction and reconstruction on rain flood and extreme high temperature events.

The invention discloses a dual-targeting ultrasonic contrast agent and a preparation method thereof. The contrast agent is an Integrin alpha v beta 3/MCP-1 dual-targeting micro-vesicle, the dual-targeting micro-vesicle comprises a lipid shell and a gas inner core, and the external surface of the lipid shell is connected with an Integrin alpha v beta 3 monoclonal antibody and an MCP-1 monoclonal antibody. Through the combined application of different target spots, the targeting efficiency of the contrast agent can be effectively increased, and the degree of enrichment of the carrying genes in the target tissue can be greatly increased. In addition, the contrast agent disclosed by the invention is an ultrasonic contrast agent with double functions of development and treatment, and tumor images can be accurately observed in real time through an ultrasonic imaging system; and after gene transfection is realized through high-strength ultrasonic irradiation, the tumor gene treatment effect can be achieved.

The invention provides a tumor tissue and cell dual targeted mesoporous silicon dioxide nano drug-loading particle. The tumor tissue and cell dual targeted mesoporous silicon dioxide nano drug-loadingparticle is constituted by a mesoporous silicon dioxide nano particle with the modified surface and a drug; the mesoporous silicon dioxide nano particle with the modified surface is constituted by amesoporous silicon dioxide nano particle body with the amine-modified surface, a polyacrylic acid film layer wrapping the mesoporous silicon dioxide nano particle body with the amine-modified surfacethrough the electrostatic effect, and polyethylene glycol connected with polyacrylic acid in the polyacrylic acid film layer through amido bonds; and the polyacrylic acid film layer serves as a blocking valve and can respond to change of the pH value to enable a pore passage of the mesoporous silicon dioxide nano particle with the amine-modified surface to be in a blocked or opened state, and thedrug is located in a pore passage structure of the mesoporous silicon dioxide nano particle body with the amine-modified surface. The nano drug-loading particle can effectively avoid damage of the targeted drug or the chemotherapy drug with lymphocytotoxicity to lymphocyte to and improves the joint treating effect of targeted therapy and immunological therapy on tumourstumors.