81 results about "High mortality" patented technology

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest mortality, with patients only surviving four months) was observed responsive to treatment. The application of the invention would be to utilize one or more of these peptide hormones alone and / or in combination to treat cancer. The ability of these peptide hormones to decrease the number of adenocarcinoma cells has implications for adenocarcinomas at other sites in the body with the majority of cancers of the breast, colon and prostate also being adenocarcinomas. Adenocarcinomas also occur in the lung and other tissues. Treatment of a wide variety of cancers in addition to adenocarcinomas is anticipated by the present invention.

The invention discloses a method for preparing lactobacillus microcapsules, which relates to a method for preparing microcapsules. The method solves the defects that the prior method for preparing thelactobacillus microcapsules cannot obtain dry lactobacillus microcapsule powder easily, the lactobacilli are diffused unevenly, the mortality rate of the lactobacilli is high in the preparation process, a used crosslinking agent has certain toxicity, and the yield of the lactobacillus microcapsules is low. The method for preparing the lactobacillus microcapsules comprises the following steps: firstly, mixing a core material and a wall material; secondly, preparing a primary emulsion; thirdly, preparing a microcapsule oil solution; fourthly, preparing a multiple emulsion; and fifthly, performing condensation, solidification and vacuum freeze drying. The method for preparing the lactobacillus microcapsules can obtain the dry lactobacillus microcapsule powder and avoid the defects of the uneven diffusion of the lactobacilli and the high mortality rate by means of the vacuum freeze drying; the method uses no crosslinking agents and has no toxic action on the lactobacilli; the external water phase is not miscible with the internal water phase; and the yield of the lactobacillus microcapsules prepared by the method reaches 84.6 percent, and the freeze-drying survival rate reaches over 60.107 percent.

The application provides data from a clinical trial of a PSD-95 inhibitor in subjects undergoing endovascular repair of an aneurysm in or otherwise affecting the CNS. The subjects were stratified by whether the aneurysm ruptured before performing the endovascular surgery. Rupture is associated with higher mortality or increased debilitation if a subject survives. The trial provided evidence of significant benefit in subjects with and without aneurysm rupture before endovascular was surgery performed. Surprisingly, the subjects benefiting most from treatment as judged both by pathology and neurocognitive outcome were those in which the aneurysm had ruptured causing a subarachnoid hemorrhage. These data constitute evidence that a PSD-95 inhibitor is beneficial not only in ischemic and hemorrhagic stroke but in forms of hemorrhage in or affecting the CNS, particularly, subarachnoid hemorrhage.

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

The invention relates to beaver rabbit feed and a preparation method thereof, wherein the feed comprises the following raw materials in percentages by weight: 25-45 corn gluten, 8-20 bran, 8-25 vinasse, 3-5 pine needle, 7-15 corn, 3-7 unite bran, 7-15 bean pulp, 2-7 rapeseed meal, 2-4 binding agent, 1-4 premix compound, 0.55 lysine and 0.55 methionine-cystine. The preparation method comprises thefollowing steps: getting the materials ready; crashing; treating the pine needle; stirring; granulating; packing; and putting in storage. The feed can avoid a beaver rabbit from getting gastro-intestinal diseases during the growth process, solves the long-standing difficult problem of high death rate of beaver rabbits due to gastro-intestinal diseases and has the survival rate up to 90-95 percent;the raw materials of the feed are vegetal without containing chemical ingredients and belong to green environment-friendly feeds; fur and meal of the beaver rabbits fed by the feed not only have goodquality, but also no any toxic hazards to the human body, wherein the fur is suitable for manufacturing top-grade clothes and ornaments, and meal and internal organs can be used as high-class nutritious foods or medicines; in addition, the feed has wide materials, low price, simple preparation method and low production cost.

The invention provides a method for nurturing large-sized high quality nucleated pearls, relating to a producing method for nurturing large-sized nucleated pearls, the problems of high mortality of freshwater nucleated pearl pearly mussel, high nuclear spitting rate and bad smooth finish need to be solved. The technology programmes of the invention includes two processes: pearly mussel pearl sac nurturing and nucleated pearl nurturing, which are characterized in that: during the process of pearly mussel pearl sac nurturing, enlarge the small inserted slices into squares of 8mm-10mm, each of the left and right mussel has two squares, the squares are placed in the thickest areas at the middle and back part of the mantle membrane central membrane, after the pearly mussel are nurtured for 2-3 years, fetch the pearls without nuclei in the pearly mussel, insert pearl nuclei of 9-15mm and hanging nurture them in pearl nurturing water area. The invention is suitable for nurturing large sized nucleated pearls.

A distant hybridization method of Oncorhynchus masou and Oncorhynchus mykiss relates to a distant hybridization method of cold water fishes. The invention resolves the problems of Oncorhynchus masou of nonsynchronous male and female maturing, low rate of emergence, bad adversity resistance, high mortality rate of ripe fishes after propagation, and the like, under the conditions of artificial cultivation. The steps of the inventive method are as follows: firstly, cultivations are respectively carried out, so that progenitive parents can be synchronously matured; secondly, artificial fertilization is carried out; thirdly, breeding is carried out. The method of the invention has stronger operability and good suitability, thereby avoiding the limitations of a hormone-induced method. The first filial generation of coenospecies cultivated by the invention has fast growing, tender meat, strong adversity resistance and high survival rate after cultivation, thereby having lower cultivation cost; compared with self cross of Oncorhynchus masou, the growth rate is increased by 10-15%, the survival rate is increased by 30%, the fertilization rate is above 90%, the hatchability rate is above 80%, after propagation, the mortality rate is below 8.7%, and the indexes of fleshcolor, tenderness, pH value, water loss rate and water holding capacity are all in accordance with the requirements of excellent-quality cold water fishes.

The invention relates to the field of feeds for beasts and birds, and particularly relates to a chick feed for preventing globidiosis. The feed is prepared from the following raw materials in parts by weight: 50-60 parts of brown rice, 45-55 parts of extruded barley, 35-40 parts of rice bran, 40-50 parts of rice hull powder, 25-30 parts of dry yellow vinasse, 180-200 parts of maize meal, 50-60 parts of rapeseed meal, 1-2 parts of kapok oil, 2-3 parts of chlorella powder, 1-2 parts of dry cheese, 2-3 parts of defatted yellow mealworm meal, 1-2 parts of pig bone meal, 1-2 parts of mountain flour, 5-8 parts of Chinese herbal medicine additives, 1-2 parts of humifuse euphorbia herb, 2-3 parts of ixeris chinensis, 1-2 parts of discolor cinquefoil herb, a defined amount of salt and 4-5 parts of a phagostimulant, wherein the Chinese herbal medicine additives comprise 2-3 parts of sweet wormwood root, 1-2 parts of rangoon creeper fruit, 2-3 parts of sanguisorba officinalis and 1-2 parts of golden cypress. The chick feed provided by the invention is additionally provided with the natural drug active ingredients, the problem of high mortality, caused by coccidiosis, of chicks can be effectively relieved, the disease and bacterium resisting capacity of the chicks is enhanced, and the chicks fed with the feed are strong in physique, active in intake and good in growth state.

The invention provides a full-length cDNA sequence of insect E93 gene and the application of dsRNA of the E93 gene in pest control. Specifically, the full-length cDNA sequence of the E93 gene having asequence of SEQ ID NO: 1 is acquired from a locusta migratoria transcriptome database by a bioinformatics method; the dsRNA of the gene is designed and synthesized according to SEQ ID NO: 1, and canbe injected into locusta migratoria coelom to specifically silence a target gene, so that the growth and the development of locusta migratoria are hindered to cause death; and multiple experiments show that the mortality rate reaches 100%. Since specificity and high mortality rate of the dsRNA of the E93 gene provided by the invention have an important practical significance on pest control, a novel way can be provided for pest control.

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

The application provides data from a clinical trial of a PSD-95 inhibitor in subjects undergoing endovascular repair of an aneurysm in or otherwise affecting the CNS. The subjects were stratified by whether the aneurysm ruptured before performing the endovascular surgery. Rupture is associated with higher mortality or increased debilitation if a subject survives. The trial provided evidence of significant benefit in subjects with and without aneurysm rupture before endovascular was surgery performed. Surprisingly, the subjects benefitting most from treatment as judged both by pathology and neurocognitive outcome were those in which the aneurysm had ruptured causing a subarachnoid hemorrhage. These data constitute evidence that a PSD-95 inhibitor is beneficial not only in ischemic and hemorrhagic stroke but in forms of hemorrhage in or affecting the CNS, particularly, subarachnoid hemorrhage.

The invention discloses an application of recombinant adenovirus of human-carrying WWOX gene to prepare antineoplastic drug in the molecular biological domain, which is characterized by the following: constructing recombinant adenovirus of human-carrying WWOX gene; establishing drug tolerant model A549 Paclitaxel drug-tolerant strain and gene transmission method; observing the expression of adenovirus in the A549 / T cell; reversing the expression of Paclitaxel and cisplatin through WWOX in the external drug sensitive test. The lung cancer is malignant tumour with highest mortality based on general chemotherapy as main therapeutic method, but most of NSCLC displays insensitivity corresponding to chemotherapy in vivo and in vitro. The invention can reverse the drug tolerance of lung cancer cell, which provides new method to solve the drug tolerant problem of malignant tumour.

The invention provides a traditional Chinese medical composition for treatment of sheep pox. The traditional Chinese medical composition consists of the following components by weight: 1-120 parts of honeysuckle, 1-120 parts of wild chrysanthemum, 1-120 parts of dandelion, 1-120 parts of herba violae, 1-115 parts of radix scutellariae, 1-115 parts of radix isatidis, 1-110 parts of cimicifugae foetidae, 1-115 parts of lithospermum, 1-110 parts of semiaquilegia root and 1-110 parts of liquorice. According to a method of Chinese veterinary dialectical treatment, the honeysuckle, the wild chrysanthemum, the dandelion, the herba violae, the radix scutellariae, the radix isatidis, the cimicifugae foetidae, the lithospermum, the semiaquilegia root and the liquorice are used together, a contagious disease caused by a sheep pox virus, namely sheep pox, can be treated effectively, typical smallpox on the body skin and sometimes the mucosa can be alleviated effectively, and the high mortality caused by fever of ill sheep can be reduced significantly.

The invention relates to a breeding method for brachymystax lenok triploid fingerling. The breeding method comprises the following steps: in 15 to 20 min after fertilization, placing fertilized ova into a water bath at 17 to 20 DEG C, and carrying out transition for 1 min; then carrying out heat treatment in a water bath at 26 DEG C for 10 to 20 min; and carrying out incubation in an incubator with an incubation water temperature of 6 to 10 DEG C. The brachymystax lenok triploid fingerling can be obtained in about 30 days through the method provided by the invention. According to the invention, the fertilized ova reach an eyed rate of 80% or above and an incubation rate of 90% or above in an incubation period; and flow cytometer detection results show that a triploid rate of the fingerlingobtained by using the method provided by the invention reaches 100%. The breeding method for the brachymystax lenok triploid fingerling provided by the invention alleviates problems like high mortality of parent brachymystax lenok after propagation, slow growth speed and low disease resistance of young brachymystax lenok and low survival rate of juvenile brachymystax lenok in mouth-opening acclimation, has advantages like low cost and easy operation, and has good market value.

The invention relates to the technical field of planting of Citrus Or and discloses a method of cultivating Citrus Or by green manure intercropping. The method comprises (1) selecting a plantation site, and building a plantation, to be specific, selecting a level land or low-lying land as the plantation having the soil, air and irrigation water quality meeting the 'three-product one-indication' standard of producing area environment; (2) selecting plantlets; (3) carrying out field planting; (4) applying fertilizers three years after field planting; (5) shaping and pruning young trees; (6) carrying out bud control and flower-fruit thinning techniques for the young trees; (7) intercropping grass, to be specific, intercropping a leguminous dwarf herb green manure among rows of fruit trees; (8) culturing robust autumn shoots; (9) pruning fruiting trees; (10) picking; and (11) cleaning the plantation. The problems of the prior art can be solved that unreasonable selection for a plantation site causes high mortality of seedlings, fertilizer application means are improper, planting management is unscientific, shoot tips and buds are not managed, Citrus Or grows slow, and fruit quality andyield are low.

The invention discloses an application of arsenical sulphide taking realgar as a representative in preparing a medicine resisting malignant tumours. The invention also discloses an application of the arsenical sulphide in preparing a medicine resisting bacteria. The problems of long treatment process, easy transfer of the malignant tumours, high mortality rate and the like exist in the process of treating the malignant tumours. The invention is invented for solving these problems. Because the arsenical sulphide has the characteristic of enabling the activities of all proteins to be lost, the arsenical sulphide has a fatal destruction function to DNA in various malignant tumours and DNA in various bacteria. Thereby, the aim of resisting various malignant tumours and various bacteria is achieved.

The invention discloses a method for promoting oestrus of cattle and increasing the hybridization conception rate of the cattle. The Ovsynch / TAI technology is adopted in the method. The method is characterized in that a statin recombinant fusion protein oil emulsion vaccine is injected according to the dosage of 1 ml per cattle within five days before or after Ovsynch treatment is carried out on the cattle for the first time. According to the method, statin recombinant fusion protein oil emulsion vaccine immunity and the traditional regular oestrus and regular ovulation technology are combined, so that cows generate statin antibodies, the hypophysis is promoted to secrete FSHs to promote growth of follicles, the ovary is promoted to secrete more activins to promote growth of the follicles and maturity of ova, oestrus of the cows and buffaloes is greatly improved, the hybridization conception rate of the cows and the buffaloes is greatly increased, the frequency of hybridization for pregnancy of the cows is lowered, consumption of manpower and material resources is greatly reduced, the production cost is lowered, the high mortality, caused by reduction of fecundity, of the cows and the buffaloes is decreased, and good economic and social benefits can be achieved.

The invention relates to a device for storing anaerobic granular sludge and a method thereof, particularly to a device for storing anaerobic granular sludge in beer industry wastewater treatment and a method thereof. The invention solves the problems of the prior anaerobic granular sludge technique, including complex process, high cost, reduced treatment specificity of original granular sludge, and high mortality rate and remarkably reduced activity of anaerobic granular activated sludge fed into a target anaerobic device. The sludge outlet port of a sludge inlet pipe of the inventive device communicates with a sludge inlet port at the top of the tank, and the sludge outlet port at the bottom of the tank communicates with the sludge inlet port of the sludge outlet pipe. The storage method comprises the steps of: storing the anaerobic granular sludge used in the beer wastewater treatment process in the inventive anaerobic granular sludge storage device, introducing nutrient solution, and storing. The inventive device has the advantages of simple structure, small floor area, and flexible application manner. The inventive method retains the treatment specificity and original activity of the granular sludge; and has the advantages of high survival rate, simple process, low cost, convenient application, and applicability to industrial production.

The invention relates to an anti-cancer agent containing α-chain protein (α-fragment) of HGF (hepatocyte growth factor) as an active ingredient. The active ingredient of α-fragment has a specific suppressing effect on invasion and metastasis of cancer cells such as gallbladder cancer, lung cancer and other, which are highly metastatic and result in a high mortality. Therefore, the agent of the invention is used in treatment and prevention of cancer as an anti-cancer agent, and is extremely useful clinically.

Stable, liquid fertilizer compositions comprising nickel, cobalt, and molybdenum are provided herein. The fertilizer compositions are capable supplying high levels of micronutrients to seeds at low doses of the compositions. The compositions generally have low salinity and a pH from about 6.0 to about 8.0, thereby avoiding the high mortality rates of beneficial soil bacteria, which has been a major problem with prior seed fertilizers. Also provided herein are methods of forming and using the fertilizer compositions. Notably, it has been discovered that monoethanolamine molybdate solutions can be used to provide high levels of molybdenum to seed surfaces in a stable liquid formulation.

The invention provides a compound feed for caged laying ducks. The feed consists of the following raw materials: corn, rice bran, soybean meal, meat and bone meal, distiller's dried grains with solubles, saccharomyces cerevisiae-fermented distiller's grains, barley, middling flour, calcium hydrogen phosphate, lysine, methionine, threonine, choline chloride, salt, phytase, a complex enzyme preparation, montmorillonite, vitamin C, multivitamins and complex trace elements. The invention adopts the combination of the saccharomyces cerevisiae-fermented distiller's grains, the meat and bone meal, the montmorillonite and the vitamin C, and takes into consideration the production and health of laying ducks, so that the laying ducks have the characteristics of comprehensive nutrients, high laying rate, stable egg production and long peak laying days. The feed can significantly improve the anti-stress ability and immunity of laying ducks, and effectively solve the problems of poor eggshell quality and high mortality and elimination rate of caged laying ducks. The invention also discloses a preparation method of the compound feed for caged laying ducks, and the method has the characteristicsof being simple in process, convenient for process parameter control and suitable for large-scale production.

The invention discloses an ecological breeding method for Mashan black goat mutton sheep in a high-humidity area, which includes the steps of sheep house construction, lamb selection, drinking water management, feed management, daily management and timely marketing. The feed management includes the steps of a lamb stage, a growing stage and a fattening stage. By playing wolf cry to frighten sheep,the sheep can escape everywhere, the disease resistance is improved, the healthy growth of the sheep is ensured, the feed utilization rate is high, a microecological preparation is added into drinking water, the number of a beneficial flora in an intestinal tract is increased, and the digestive capacity is improved, thereby improving the feed utilization rate; a good living environment is provided for the sheep, the disease resistance is improved, the occurrence of various diseases is reduced, the strong appetite of the mutton sheep is maintained, the feed intake is increased, the feed utilization rate is high, and mutton is compact, fragrant and sweet, and high in quality; the living environment of wild sheep is imitated, the problems of low feed utilization rate, slow growth and high mortality of mutton breeding in high-humidity areas are solved, the cost of mutton breeding is reduced, the mutton is pollution-free, and the lean meat rate is higher.

The invention relates to a rapid mycorrhization method of orchid aseptic seedlings. By the method, problems of slow seedling growth, high mortality and the like in artificial breeding of orchid in the prior art are solved. The rapid mycorrhization method of orchid aseptic seedlings comprises a step of preparing a culture medium and a nutrient solution and a step of inoculating aseptic seedlings, wherein the culture medium is composed of peat and sand; the volume ratio of peat to sand is 1:1.5-3; and during the step of inoculating aseptic seedlings, tissue culture rooting seedlings or aseptic sowing seedlings are transplanted into the culture medium which has undergone aseptic treatment, and a strain piece is inoculated near roots of the seedlings. The strain piece is a strain with the collection number of CGMCC No: 9222 or CGMCC No: 9247. The strain piece inoculation position is 0.3-2cm from the roots. The seedlings are placed in a culture room to be cultured after inoculation. By the above method, orchid seedlings form mycorrhiza rapidly, infection rate is high, and seedlings grow fast. The method can be used in orchid seedling production.

The invention belongs to the technical field of animal models of diabetes mellitus, and particularly relates to a modeling method for an animal model of type 2 diabetes mellitus. The method comprisesthe step that 20-100 lumens and 8-10 hours of illumination is applied during nighttime animal sleep for induction, wherein the induction time is 2-6 month. The method provided by the invention fills the blank of modeling of the animal model of the type 2 diabetes mellitus by a natural induction method, shortens the modeling time of the animal model, and has fewer side effects; and the problems such as too serious obesity and too high mortality of individuals do not easily occur, and feeding costs are greatly reduced.

Use of interferon-beta (IFN-β) and / or IFN-λ for treating rhinovirus (RV) infection in elderly people, particularly elderly people who are, or have been long-term smokers, especially those who have a clinical history of recurrent RV infections, and may have other medical conditions, such as cardiac or circulation problems, and who are liable to suffer severe complications / high mortality from poor innate ability to fight such a viral infection.

The invention discloses a molecular diagnosis marker for pyemia. Specifically, the diagnosis marker is CYB561A3, and the expression level of CYB561A3 in pyemia patients is reduced. By the adoption of the pyemia diagnosis product, early diagnosis of pyemia is made possible, high mortality caused by diagnosis delay is reduced, and medical resources are saved.

Disclosed is an effective prophylactic / therapeutic vaccine which can protect from scuticociliatosis, particularly can protect from the infection by Philasterides dicentrarchi that has a high mortality rate. The vaccine comprises (1) an inactivated product of a strain having the same serum type as that of P. dicentrarchi strain Iyo I, (2) an inactivated product of a strain having the same serum type as that of P. dicentrarchi strain Nakajima, and (3) an inactivated product of a strain having the same serum type as that of P. dicentrarchi strain Mie0301 as active ingredients.