249 results about "Ovarian function" patented technology

Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.

Methods and apparatus for interpreting vaginal measurement data by electronic means without the need for the user to take part in the data interpretation process. More specifically, an intelligent probe monitors folliculogenesis and correlates the ovarian function data to probe profile characteristics of the female reproductive cycle. A fertile window is defined with reference to the correlation between folliculogenesis and probe cyclic profiles. Data stored within the apparatus can be downloaded into an external display appliance or data analysis unit. Another aspect of the invention allows for continuous layout of the memory of preceding cycles in the inventory of the apparatus, retaining the most recent while erasing the most distant stored data. These methods assure a reliable fit for the diagnosis of fertility, treatment of infertility as far as timing of treatment procedures, management of subfertility and other gynecological disorders such as luteal phase deficiency or short luteal phase, and the management of premenstrual mood disorders, and of premenopausal and menopausal patients.

The invention discloses feed for improving production performance of sows. The feed consists of the following components in parts by weight: 400-600 parts of corn flour, 80-150 parts of bran, 100-180 parts of expanded soybean meal, 30-50 parts of fish meal, 180-220 parts of soybean meal, 20-45 parts of soybean oil, 10-20 parts of calcium hydrogen phosphate, 10-20 parts of stone powder, 2-3 parts of lysine, 1-3 parts of methionine, 1-3 parts of threonine, 5-10 parts of compound trace elements, 1-2 parts of compound vitamin, 1-2 parts of oligopeptide, 0.5-1 part of flavone, 1-2 parts of plant extracts, 0.5-1 part of enzyme preparation, 1-2 parts of probiotics and 1-2 parts of feed antistaling agent. The feed provided by the invention can be used for adjusting the endocrine of sow bodies, promoting the development of corpus luteum, activating ovarian function, reducing the incidence of mastitis and endometritis, purifying the reproductive system, delaying the ageing of the reproductive system, improving the production performance of the sows, and increasing the economic benefit of pig raising.

The invention discloses a sow premixed feed for improving the productivity of sows. The sow premixed feed is prepared from the following components in parts by weight: 300-400 parts of puffing soybean flour, 150-250 parts of fish meal, 180-220 parts of bean pulp, 120-150 parts of calcium hydrophosphate, 100-200 parts of mountain flour, 20-30 parts of lysine, 10-30 parts of methionine, 15-35 parts of threonine, 20-30 parts of valine, 60-100 parts of compound trace elements, 12-20 parts of multivitamin, 100-200 parts of oligopeptides, 0.5-1 part of an enzymic preparation, 1-2 parts of probiotics and 1-2 parts of a feed preservative. By virtue of the feed for improving the productivity of the sows disclosed by the invention, the organism endocrine of the sows can be adjusted, the development of corpus luteum is promoted, the ovarian function is activated, the morbidity of mastitis and endometritis is reduced, a reproductive system is purified, the aging of the reproductive system is delayed, and the productivity of the sows is improved. Thus, the economic benefits of pig raising are also improved.

A genetic means of determining whether a female subject produces "pregnancy competent" oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the "pregnancy signature", also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing "pregnancy signature" genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.

The invention discloses traditional Chinese medicine hen feed capable of improving egg quality and a processing method of the feed, belonging to the field of hen feed. The feed comprises puffed corn, puffed bean pulp, green soybean dough cake, Chinese cabbage, wheat bran, salt, meat and bone meal, protein powder and traditional Chinese medicine components, wherein the traditional Chinese medicine components comprise unprepared malt, astragalus membranaceus, gorgon fruit, atractylodes macrocephala, liquorice, rhizoma drynariae, dendrobe, lily, radix polygonati officinalis, adenophora tetraphylla, hawthorn, Chinese pulsatilla root, golden cypress, brucea javanica, dried tangerine or orange peel, date, radix paeoniae alba, angelica sinensis, dried rehamnnia root, Chinese yam, qingming willow, lalang grass rhizome, Indian strawberry, Japan cypress leaves, eclipta prostrate, artocarpus hypargyreus, honewort and guava. The processing method comprises the following steps: (1) extracting a crude traditional Chinese medicine liquid sample; (2) finely preparing a traditional Chinese medicine liquid; (3) preparing the traditional Chinese medicines; and (4) preparing the feed for hens. The traditional Chinese medicine hen feed can effectively improve the intestines and stomach function and the ovarian function of hens, can improve the egg quality and is reasonable in formula, free of antibiotics chemical synthesis medicine, and safe and harmless for human bodies after people eat the eggs.

The invention discloses a Chinese herba preparation for treating the premature ovarian failure. The Chinese herba preparation is made of prepared rehmannia root, fried Chinese yam, teasel root, vinegar-processed radix bupleuri, rhizoma cyperi, curcuma aromatica, loranthus parasiticus, eucommia ulmoides, semen cuscutae, flatstem milkvetch seed, barbary wolfberry fruit, achyranthes root, dogwood, angelica sinensis, ligusticum wallichii, radix paeoniae alba, fried bighead atractylodes rhizome, codonopsis pilosula, semen plantaginis, glossy privet fruit, cornu cervi degelatinatum, colla corii asini, trigone and curcuma zedoary according to a certain weight ratio. The Chinese herba preparation has the effects of nourishing yin and blood, boosting essence, filling marrow, supplementing qi, promoting the production of body fluid, promoting qi circulation and relieving depression; the Chinese herba preparation has the good effect on improving the ovarian function, the physique of a patient can be strengthened, the Chinese herba preparation further has the advantages of being low in price and free of toxic and side effects, and therefore the effect of treating the premature ovarian failure is achieved.

The invention relates to a cell preparation for restoring ovarian function, including amniotic mesenchymal stem cells and ovarian cells. By using amniotic mesenchymal stem cells combined with ovarian cells to make cell preparations, as well as auxiliary components for preventing the multidirectional differentiation of amniotic mesenchymal stem cells and promoting the activity and normal growth and proliferation of amniotic mesenchymal stem cells and ovarian cells, at the same time, Combined with ovarian cells, amniotic mesenchymal stem cells can maintain their stem cell characteristics for a long time, and then act on the ovary through the cytokines secreted by them combined with ovarian cells to achieve the purpose of immediate and complete restoration of ovarian function; avoid cells made of single cells In the preparation, the cell properties are unstable, resulting in unstable ovarian function repair effect, poor repair effect, and failure to completely repair ovary and other defects.

A genetic means of determining whether a female subject produces "pregnancy competent" oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the "pregnancy signature", also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing "pregnancy signature" genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments. Additionally, an improved RNA amplification protocol is provided herein referred to as the CRL amplification protocol which is suitable for reproducibly amplifying all the RNAs expressed by a cell sample, even when only a few cells are available.

The invention relates to a feed, and in particular relates to a Chinese herbal medicine laying hen feed. The feed is characterized by being prepared from the following bulk pharmaceutical chemicals in parts by weight: 5-8 parts of cape jasmine, 3-5 parts of allicin, 8-10 parts of cinnamon, 5-8 parts of clove, 6-9 parts of dried tangerine peel, 9-12 parts of green tangerine peel and 6-8 parts of officinal magnolia bark. The feed has the following beneficial effects: the gastrointestinal functions and ovarian functions of the laying hens can be enhanced; the immunities of the laying hens can beimproved; the tastes of the eggs are obviously improved; the eggs are easy to digest and absorb; the contents of selenium, calcium and zinc in the eggs are obviously improved; the nutritional values and health care effects of the eggs are obviously reinforced; when the feed is used for cage reared laying hens, the quality difference between the eggs of the cage reared laying hens and the domesticeggs is obviously reduced; and the feed has the characteristics of wide raw material sources, convenience in processing, low cost and the like and has very considerable market prospect.

A method of improving cumulative embryo score may comprise administering an androgen to a human female, for example, DHEA, for at least about four consecutive months followed by harvesting and fertilizing oocytes and forming embryos. Between about 50 mg and about 100 mg of DHEA may be administered to a human female per day. Moreover, a method of increasing the quantity of fertilized oocytes in one cycle of in vitro fertilization may comprise administering an androgen to a human female for at least about four consecutive months, harvesting and fertilizing the oocytes. Furthermore, a method of increasing the quantity of day 3 embryos from one cycle of in vitro fertilization may comprise administering an androgen for at least about four consecutive months, harvesting and fertilizing the oocytes and forming day 3 embryos. A method of normalizing ovarian DHEA also may include administering an androgen for at least about four consecutive months. A method of increasing the euploidy rate in embryos may include administering an androgen for at least about four consecutive weeks.

The present invention discloses a female healthcare food and a preparation method thereof. The female healthcare food comprises the following raw materials in parts by weight: 30-60 parts of lepidium meyenii, 20-55 parts of kudzu vine root and 10-20 parts of Chinese wolfberry fruits. According to the preparation method, biological health activity molecules are extracted through a modern Chinese medicine technology, and the extracted biological healthcare active molecules are added to edible materials and prepared into tablets, granules, hard capsules or oral solutions. The lepidium meyenii, the kudzu vine root and the Chinese wolfberry fruits are processed by a bionanotechnology, such that bioavailability of the healthcare active molecules can be improved, and a female healthcare food can be prepared by a fine processing. The prepared female healthcare food is safe, effective, non-toxic and harmless. The female healthcare food has collaborative action for improving sexual function, improving fertility, regulating endocrine, reducing bone rarefaction caused by ovarian function decline and other related diseases, and improving immune function.

The invention discloses a Chinese herbal medicine feed for laying hens, and a preparation method thereof. The Chinese herbal medicine feed for the laying hens is prepared from the following raw materials: corn flour, bean pulp, bran, rice bran, eggshell powder, tenebrio molitor powder, allicin, liquorice, cinnamon, motherwort herb, radix puerariae, eclipta alba, radix rehmanniae preparata, black barbary wolfberry fruit, rhizoma phragmitis, sodium bicarbonate, vegetable oil, table salt and multivitamin. According to the Chinese herbal medicine feed for the laying hens, the gastrointestinal function and the ovarian function of the laying hens are improved, the immunity of the laying hens is improved, the taste of eggs is obviously improved, the eggs are easy to digest and absorb, the contents of selenium, calcium and zinc of the eggs are remarkably improved, and the nutritive value and the health care effect of the eggs are remarkably improved; when the feed is used for caged laying hens, the quality difference between the eggs of the caged laying hens and the home eggs is obviously reduced; the Chinese herbal medicine feed for the laying hens has the characteristics of being wide in raw material source, convenient to processing, low in cost, and the like, thus having very considerable market prospect.

Methods and apparatus for interpreting vaginal measurement data by electronic means without the need for the user to take part in the data interpretation process. More specifically, an intelligent probe monitors folliculogenesis and correlates the ovarian function data to probe profile characteristics of the female reproductive cycle. A fertile window is defined with reference to the correlation between folliculogenesis and probe cyclic profiles. Data stored within the apparatus can be downloaded into an external display appliance or data analysis unit. Another aspect of the invention allows for continuous layout of the memory of preceding cycles in the inventory of the apparatus, retaining the most recent while erasing the most distant stored data. These methods assure a reliable fit for the diagnosis of fertility, treatment of infertility as far as timing of treatment procedures, management of subfertility and other gynecological disorders such as luteal phase deficiency or short luteal phase, and the management of premenstrual mood disorders, and of premenopausal and menopausal patients.

The invention relates to an artificial reproduction pregnancy prediction method and device built by a machine learning model. The method comprises: acquiring maternal blood hormone physiological detection data and ovarian function physiological detection data; establishing a hormone / physiological test-pregnancy SVM model in combination with a support vector machine algorithm; obtaining maternal embryo images; establishing an embryo image-embryo quality DNN model in combination with a deep neural network algorithm; obtaining a maternal clinical medical information prediction value according toa pregnancy test result report and the hormone / physiological test-pregnancy SVM model; obtaining an embryo quality evaluation prediction value according to the pregnancy test result report and the embryo image-embryo quality DNN model; and combining the two prediction values to obtain an artificial reproduction pregnancy prediction value. The method provided by the invention is relatively high inaccuracy, can avoid the situation that the final result is influenced due to the difference of different experiences, and can effectively improve the situation that a single model is easy to form over-conservative prediction when the data volume is small.

The invention provides a preparation method of oyster bioactive peptides. The method comprises the following steps: carrying out high speed homogenate on fresh oyster meat, centrifuging, and adjusting the pH to 7 in order to obtain crude oyster proteins; centrifuging the obtained oyster protein suspension, homogenizing through a high speed disperser, adding Papain, maintaining the pH value of the obtained solution unchanged, heating reactants for enzyme killing, and cooling to obtain freeze-dried oyster protein powder; and preparing a solution, stirring, centrifuging, determining the content of amino acids in the above obtained supernatant which is a high temperature enzyme-killed oyster enzymatic hydrolysate through a biosensor, separating the oyster enzymatic hydrolysate through a SephadexG-25 chromatography column, eluting, freeze-drying, and carrying out gel column desalination to obtain the oyster bioactive peptides. The oyster enzymatic hydrolysate obtained in the invention contains high content of total amino acids, so the activity of biological components is effectively protected, and the ovarian granulosa cell function interference effect caused by bisphenol A can be substantially antagonized; and the oyster bioactive peptides can be applied in the preparation of medicines for treating the ovarian function disorder caused by the exposure of chemical environment interferent bisphenol A.

The invention provides a ghrelin-containing sheep embryo in-vitro culture solution. The sheep embryo in-vitro culture solution takes a TCM199 culture solution as a matrix; and the matrix also contains 400-800mg / mL ghrelin, 0.15mg / mL glutamine, 100IU / mL penicillin, 100mug / mL streptomycin and 5-10mg / mL bovine serum albumin. In the embryo in-vitro culture solution provided by the invention, ghrelin is used as the endogenous ligand of a growth hormone secretagogue receptor, and has the functions of regulating the secretion of reproductive hormone, promoting the growth of ovarian follicle and ovulation, adjusting the ovarian function, participating in the early developmental regulation of embryo and the like. By applying ghrelin to the sheep embryo in-vitro culture, the ectogenesis of the embryo can be effectively promoted, thus the problem of low ectogenesis rate of the sheep early embryo at present is solved. The sheep embryo in-vitro culture solution provided by the invention has relatively low economic cost, and is convenient to popularize and use in production.

The invention provides a camellia nitidissima ginseng tablet candy, which comprises the following raw materials by weight: 18-24 parts of camellia nitidissima, 4-8 parts of ginseng, 16-22 parts of kudzuvine root, 11-15 parts of moringa seed, 8-12 parts of pine pollen, 8-12 parts of Chinese wolfberry, 8-12 parts of Maca, 6-10 parts of cordyceps militaris, 6-10 parts of red dates, and 6-10 parts of honey. The invention also provides a preparation method of the camellia nitidissima ginseng tablet candy. All the raw materials of the camellia nitidissima ginseng tablet candy cooperate with each other to synergistically act on the endocrine system, thus gradually activate the female ovarian functions, regulating ovary mitochondria hormone secretion, improving the sexual life quality of husband and wife, expelling toxin and helping sleep, increasing skin elasticity, preventing and treating gynecological diseases, significantly reducing chloasma, and fully restoring the maiden youthful vitality of the body.

The invention discloses new application of an extract of Chinese angelica and szechuan lovage rhizome composition to the preparation of a medicament for promoting ovary granular cell proliferation. Intensive study is performed on a large quantity of ancient and modern prescriptions and traditional Chinese medicine application data, traditional Chinese medicine resources are fully utilized according to a traditional Chinese medicine theory and the pathogenesis of ovarian functional disturbance and insufficient growth of ovary granular cells and a large number of pharmacological tests are performed based on the current researches of Chinese angelica and szechuan lovage rhizome, so that new application of the Chinese angelica and szechuan lovage rhizome to the treatment of ovarian functional disturbance and the promotion of ovary granular cell proliferation; moreover, the weight ratio of the Chinese angelica and szechuan lovage rhizome composition with the highest activity is screened through a large quantity of experiments. When clinically taken as a medicament for treating ovarian functional disturbance and promoting ovary granular cell proliferation, the extract has the advantages of good curative effect, definite active ingredient, small side effect, convenience of taking and the like.

The spot eliminating and physique strengthening composition consists of wheat chlorine, protocyanidin, chitosan, aloin, nanometer level pearl powder and soybean isoflavone in certain weight proportion. It may be orally taken to regulate acid-base balance of human body fluid, eliminate endotoxin, replenish estrogen for women and reach other functions; and externally applied to eliminate toxin, nurse face, eliminate spots and beautify.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The invention discloses a feed for laying hens. The feed for laying hens comprises the following raw materials in parts by weight: 70-90 parts of corn protein powder, 10-20 parts of beer meal, 15-25 parts of sorghum, 15-25 parts of wheat, 10-20 parts of wheat bran, 10-20 parts of green vegetable powder, 10-16 parts of earthworm powder, 6-10 parts of locust powder, 8-12 parts of eggshell powder, 6-8 parts of fish powder, 1-3 parts of calcium hydrophosphate, 4-8 parts of vegetable oil, 2-4 parts of salt and 1-3 parts of complex mineral. The prepared feed for laying hens is rich and balanced in nutrients and can conduce to enhancing the gastrointestinal functions and ovarian functions of the laying hens and enhancing the immunities of the laying hens.

The invention discloses a health food for preventing and treating the premature aging of women and a preparation method thereof. The health food is prepared from the following ingredients in parts by weight: 10-15 parts of wolfberry, 10-15 parts of glossy privet fruit, 10-15 parts of prepared rehmannia root, 15-20 parts of radix ophiopogonis, 10-15 parts of fructus psoraleae, 10-15 parts of angelica sinensis, 10-15 parts of coix seed, 20-30 parts of beef extract, 20-30 parts of spina date seed and 2-3 parts of soy isoflavone. By adopting the health food, the function of the ovary can be improved, the growth of the ovarian follicle can be enhanced, the action of the estrogen sample can be exerted and the osteoporosis can be prevented.

A general benzifuran is extracted from the Styrax plant and can be used to prepared injection, tablet, capsule, etc for preventing and treating early failure of ovary function, climacteric syndrome, osteoporosis, polycystic overy syndrome, acyesis, etc. Its preparing process is also disclosed.

A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse, thawing the whole organ including vasculature and introducing the whole organ into a recipient so that the organ is supplied with blood by vasculature belonging to the recipient. Further disclosed is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility. The method include removing a whole gonadal organ from the patient, cryo-preserving the whole gonadal organ, conducting the treatment and waiting for an effect thereof to subside, thawing the whole gonadal organ and introducing the whole gonadal organ where it is supplied with blood by the vasculature system of the patient. Further disclosed is a method of assuring a supply of viable gametes for future use, the method includes removing a whole gonadal organ from a patient, cryo-preserving the whole gonadal organ, waiting until viable gametes are desired by the patient, thawing the organ and introducing the gonadal organ into the patient so that it is supplied with blood by a vasculature system belonging to the patient.

Ovarian autoimmunity is implicated in ovarian dysfunction associated with premature ovarian failure (POF) and unexplained infertility. A rapid, quantitative, and inexpensive method of clinical diagnosis of ovarian autoimmunity is provided. Diagnosis is provided by detection of autoantibodies that react with an ovarian antigen, 17 -alpha-hydroxylase. This diagnostic method is applicable to ovarian autoimmunity unassociated with polyglandular disease.

The invention discloses a vitamin composition and an application of the vitamin composition in preparing medicaments, health-care products or foods for preventing and treating climacteric syndrome, premature ovarian failure, polycystic ovaries and / or irregular menstruation. The composition is safer and more effective compared with the prior art, shows more excellent effects than independently-applied vitamin, and can be used for improving skin allergy symptoms caused by independently taking niacin.

The present invention relates to a new method for premature ovarian failure treatment, wherein human endometrium stem cells can promote ovarian function recovery. Particularly the present invention discloses applications of human endometrium stem cells in preparation of drugs for premature ovarian failure treatment, specifically in preparation of cell drugs for premature ovarian failure treatment, and / or medical technologies.

The invention belongs to the technical field of biomedicines and particularly relates to a composition for improving premature ovarian failure, a preparation method therefor and application of the composition. According to the composition for improving the premature ovarian failure, provided by the invention, an in-vitro-constructed human uterine endometrium stem-cell cell membrane and a mesenchymal stem cell exosome are used in a compounded manner, thus, the development of ovarian follicles can be promoted, ovaries can be promoted to secrete an anti-Mullerian hormone, an ovarian follicle generator promoting level can be regulated, the apoptosis of ovarian cells can be inhibited, the adverse reserve function disease of the ovaries can be improved, the effect of improving primary or secondary premature ovarian failure is good, and thus, a new way of think is provided for clinically treating ovarian insufficiency and polycystic ovarian syndrome.

A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the “pregnancy signature”, also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing “pregnancy signature” genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.